Mouse SR-AI/MSR APC-conjugated Antibody

Catalog # Availability Size / Price Qty
Detection of SR‑AI/MSR in RAW 264.7 Mouse Cell Line by Flow Cytometry.
1 Image
Product Details
Citations (6)
Supplemental Products

Mouse SR-AI/MSR APC-conjugated Antibody Summary

Species Reactivity
Detects mouse SR‑AI/MSR in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross‑reactivity with recombinant human SR-AI is observed.
Monoclonal Rat IgG2B Clone # 268318
Protein A or G purified from hybridoma culture supernatant
Mouse myeloma cell line NS0-derived recombinant mouse SR‑AI/MSR
Accession # AAA39747
Supplied in a saline solution containing BSA and Sodium Azide.
Allophycocyanin (Excitation= 620-650 nm, Emission= 660-670 nm)


Recommended Concentration
Flow Cytometry
10 µL/106 cells
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry Detection of SR-AI/MSR antibody in RAW 264.7 Mouse Cell Line antibody by Flow Cytometry. View Larger

Detection of SR‑AI/MSR in RAW 264.7 Mouse Cell Line by Flow Cytometry. RAW 264.7 mouse monocyte/macrophage cell line was stained with Rat Anti-Mouse SR-AI/MSR APC-conjugated Monoclonal Antibody (Catalog # FAB1797A, filled histogram) or isotype control antibody (Catalog # IC013A, open histogram). View our protocol for Staining Membrane-associated Proteins.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Preparation and Storage

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.

Background: SR-AI/MSR

The scavenger receptor (SR) family comprises a group of functionally defined membrane receptors that share the common ability to bind and internalize modified forms of Low Density Lipoproteins (mLDL) (1‑3). Family members are classified alphabetically. The A class include four proteins: the three subtypes of SR-A (AI, AII, and AIII) that are generated by alternative splicing of the same gene, and a structurally similar protein named MARCO (4). All A class SRs are multidomain trimeric type II membrane proteins. SR-AI has an N-terminal cytoplasmic domain, a transmembrane domain, a spacer domain, an alpha -helical coiled coil, a collagen-like domain and a C-terminal cysteine-rich domain. SR-A is expressed by most tissue macrophages, dendritic cells and Kupffer cells. It is also highly expressed by microglia in neonatal as well as Alzheimer’ Disease brains. SR-AI binds a broad range of polyanionic ligands including modified proteins (e.g. Oxidized, acetylated or maleylated LDL, Advanced glycation end-product proteins), polyribonucleotides (polyguanosine and polyinosine), polysaccharides (dextran sulfate, fucoidan), phospholipids (phosphatidylserine), bacterial products (lipopolysaccharide and lipoteichoic acid) and selected chemical compounds (silica, crocidolite asbestos). The ligand-binding region has been localized to a positively charged region in the carboxyl end of the collagen-like domain. Based on its ligand binding characteristics, SR-AI is implicated in many physiological and pathophysiological functions. Studies using SR-A knockout mouse have also suggested roles of SR-A in atherogenesis, host defense and innate immunity, acquired immune responses, macrophage adhesion, and phagocytosis of apoptotic cells (1‑3).

  1. Daugherty, A. et al. (2000) Curr. Opin. Cardiovasc. Pulm. Ren. Invest. Drugs 2:223.
  2. Platt, N. and S. Gordon (2001) J. Clin. Invest. 108:649.
  3. Platt, N. and S. Gordon (1998) Chem. Biol. 5:R193.
  4. Elomaa, O. et al. (1995) Cell 80:603.
Long Name
Macrophage Scavenger Receptor Types I and II
Entrez Gene IDs
4481 (Human); 20288 (Mouse); 25073 (Rat)
Alternate Names
CD204 antigen; CD204; Macrophage acetylated LDL receptor I and II; macrophage scavenger receptor 1; macrophage scavenger receptor type III; MSR1; phSR1; phSR2; SCARA1; SCARA1macrophage scavenger receptor types I and II; Scavenger receptor class A member 1; scavenger receptor class A, member 1; SR-A; SRAI; SR-AI

Product Datasheets

You must select a language.


Citations for Mouse SR-AI/MSR APC-conjugated Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

6 Citations: Showing 1 - 6
Filter your results:

Filter by:

  1. The compound LG283 inhibits bleomycin-induced skin fibrosis via antagonizing TGF-beta signaling
    Authors: A Utsunomiya, T Chino, H Kasamatsu, T Hasegawa, N Utsunomiya, VH Luong, T Matsushita, Y Sasaki, D Ogura, SI Niwa, N Oyama, M Hasegawa
    Arthritis Research & Therapy, 2022-04-29;24(1):94.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  2. Application of a three‑dimensional (3D) breast cancer model to study macrophage polarization
    Authors: Agata Golabek, Mariusz Kaczmarek, Ewelina Dondajewska, Kosma Sakrajda, Andrzej Mackiewicz, Hanna Dams‑kozlowska
    Experimental and Therapeutic Medicine
  3. Comparative Transcriptomic Analysis Identifies a Range of Immunologically Related Functional Elaborations of Lymph Node Associated Lymphatic and Blood Endothelial Cells
    Authors: Stella J. Berendam, Alexander F. Koeppel, Nicole R. Godfrey, Sherin J. Rouhani, Amber N. Woods, Anthony B. Rodriguez et al.
    Frontiers in Immunology
  4. Blockade of TGF-?/Smad signaling by the small compound HPH-15 ameliorates experimental skin fibrosis
    Authors: VH Luong, T Chino, N Oyama, T Matsushita, Y Sasaki, D Ogura, SI Niwa, T Biswas, A Hamasaki, M Fujita, Y Okamoto, M Otsuka, H Ihn, M Hasegawa
    Arthritis Res. Ther., 2018-03-15;20(1):46.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  5. Scavenger Receptor A Mediates the Clearance and Immunological Screening of MDA-Modified Antigen by M2-Type Macrophages
    Authors: Andreas Warnecke, Sonja Abele, Sravani Musunuri, Jonas Bergquist, Robert A. Harris
    NeuroMolecular Medicine
  6. KIT oncogene inhibition drives intratumoral macrophage M2 polarization.
    Authors: Cavnar, Michael, Zeng, Shan, Kim, Teresa S, Sorenson, Eric C, Ocuin, Lee M, Balachandran, Vinod P, Seifert, Adrian M, Greer, Jonathan, Popow, Rachel, Crawley, Megan H, Cohen, Noah A, Green, Benjamin, Rossi, Ferdinan, Besmer, Peter, Antonescu, Cristina, DeMatteo, Ronald P
    J Exp Med, 2013-12-09;210(13):2873-86.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry


No product specific FAQs exist for this product, however you may

View all Antibody FAQs

Reviews for Mouse SR-AI/MSR APC-conjugated Antibody

There are currently no reviews for this product. Be the first to review Mouse SR-AI/MSR APC-conjugated Antibody and earn rewards!

Have you used Mouse SR-AI/MSR APC-conjugated Antibody?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review