Mouse TROP-2 Antibody

Catalog # Availability Size / Price Qty
Mouse TROP-2 Antibody in Data
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Product Details
Citations (10)
Supplemental Products

Mouse TROP-2 Antibody Summary

Species Reactivity
Detects mouse TROP-2 in direct ELISAs and Western blots. In direct ELISAs, less than 30% cross-reactivity with recombinant human TROP‑2 is observed.
Polyclonal Goat IgG
Antigen Affinity-purified
Mouse myeloma cell line NS0-derived recombinant mouse TROP-2
Accession # Q8BGV3
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.


Recommended Concentration
Western Blot
0.1 µg/mL
Recombinant Mouse TROP‑2
Flow Cytometry
0.25 µg/106 cells
See below
5-15 µg/mL
See below
Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.
5-15 µg/mL
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Data Examples

Flow Cytometry Detection of TROP-2 antibody in mIMCD-3 Mouse Cell Line antibody by Flow Cytometry. View Larger

Detection of TROP‑2 in mIMCD-3 Mouse Cell Line by Flow Cytometry. mIMCD-3 mouse epithelial cell line was stained with Goat Anti-Mouse TROP-2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1122, filled histogram) or isotype control antibody (Catalog # AB-108-C, open histogram), followed by Allophycocyanin-conjugated Anti-Goat IgG Secondary Antibody (Catalog # F0108).

Immunocytochemistry TROP-2 antibody in XB2 Mouse Cell Line by Immunocytochemistry (ICC). View Larger

TROP‑2 in XB2 Mouse Cell Line. TROP-2 was detected in immersion fixed XB2 mouse teratoma keratinocyte cell line using Goat Anti-Mouse TROP-2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1122) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (yellow; Catalog # NL001) and counterstained with DAPI (blue). View our protocol for Fluorescent ICC Staining of Cells on Coverslips.

Immunohistochemistry TROP-2 antibody in Mouse Skin by Immunohistochemistry (IHC-P). View Larger

TROP‑2 in Mouse Skin. TROP-2 was detected in immersion fixed paraffin-embedded sections of mouse skin using Goat Anti-Mouse TROP-2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1122) at 3 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Goat IgG VisUCyte™ HRP Polymer Antibody (Catalog # VC004). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to cell membranes in keratinocytes. View our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Preparation and Storage

Reconstitute at 0.2 mg/mL in sterile PBS.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Size / Price
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: TROP-2

TROP-2, also named tumor-associated calcium signal transducer 2 (TACSTD2), GA733 tumor associated antigen, and epithelial glycoprotein-1 (EGP-1), is a type I transmembrane protein highly expressed in carcinomas. It was originally identified as an antigen present on human gastrointestinal tumors and is the second of two members of this family.  The other family member is GA7332, also called EpCAM, TROP1, 171A, gp40 and KSA.  TROP2 can transduce an intracellular calcium signal and may play a role in tumor growth. It also has adhesive functions.

Long Name
Tumor-associated Calcium Signal Transducer 2
Entrez Gene IDs
4070 (Human); 56753 (Mouse)
Alternate Names
Cell surface glycoprotein Trop-2; EGP1; EGP-1; epithelial glycoprotein-1; GA733-1; GA733-1GP50; gastrointestinal tumor-associated antigen GA7331; gp50; M1S1cell surface glycoprotein TROP2; Membrane component chromosome 1 surface marker 1; membrane component, chromosome 1, surface marker 1; Pancreatic carcinoma marker protein GA733-1; pancreatic carcinoma marker protein GA7331,40kD glycoprotein, identified by monoclonal GA733; T16; TACSTD2; TROP2; TROP-2; TROP2GA7331; tumor-associated calcium signal transducer 2

Product Datasheets

Citations for Mouse TROP-2 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

10 Citations: Showing 1 - 10
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  1. High-Throughput Drug Screening Identifies a Potent Wnt Inhibitor that Promotes Airway Basal Stem Cell Homeostasis
    Authors: CJ Aros, MK Paul, CJ Pantoja, B Bisht, LK Meneses, P Vijayaraj, JM Sandlin, B France, JA Tse, MW Chen, DW Shia, TM Rickabaugh, R Damoiseaux, BN Gomperts
    Cell Rep, 2020;30(7):2055-2064.e5.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  2. Relief of tumor hypoxia unleashes the tumoricidal potential of neutrophils
    Authors: K Mahiddine, A Blaisdell, S Ma, A Créquer-Gr, CA Lowell, A Erlebacher
    J. Clin. Invest., 2019;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  3. Submucosal Gland Myoepithelial Cells Are Reserve Stem Cells That Can Regenerate Mouse Tracheal Epithelium
    Authors: TJ Lynch, PJ Anderson, PG Rotti, SR Tyler, AK Crooke, SH Choi, DT Montoro, CL Silverman, W Shahin, R Zhao, CW Jensen-Cod, A Adamcakova, TIA Evans, W Xie, Y Zhang, H Mou, BP Herring, PS Thorne, J Rajagopal, C Yeaman, KR Parekh, JF Engelhardt
    Cell Stem Cell, 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  4. YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration
    Authors: S Yui, L Azzolin, M Maimets, MT Pedersen, RP Fordham, SL Hansen, HL Larsen, J Guiu, MRP Alves, CF Rundsten, JV Johansen, Y Li, CD Madsen, T Nakamura, M Watanabe, OH Nielsen, PJ Schweiger, S Piccolo, KB Jensen
    Cell Stem Cell, 2018;22(1):35-49.e7.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  5. Maternal Fat Feeding Augments Offspring Nephron Endowment in Mice
    PLoS ONE, 2016;11(8):e0161578.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  6. Pten Regulates Epithelial Cytodifferentiation during Prostate Development.
    Authors: Lokody I, Francis J, Gardiner J, Erler J, Swain A
    PLoS ONE, 2015;10(6):e0129470.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  7. Nrf2 enhances cholangiocyte expansion in Pten-deficient livers.
    Authors: Taguchi, Keiko, Hirano, Ikuo, Itoh, Tohru, Tanaka, Minoru, Miyajima, Atsushi, Suzuki, Akira, Motohashi, Hozumi, Yamamoto, Masayuki
    Mol Cell Biol, 2014;34(5):900-13.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  8. Hepatocytes, rather than cholangiocytes, can be the major source of primitive ductules in the chronically injured mouse liver.
    Authors: Sekiya S, Suzuki A
    Am J Pathol, 2014;184(5):1468-78.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  9. Global quantification of tissue dynamics in the developing mouse kidney.
    Authors: Short K, Combes A, Lefevre J, Ju A, Georgas K, Lamberton T, Cairncross O, Rumballe B, McMahon A, Hamilton N, Smyth I, Little M
    Dev Cell, 2014;29(2):188-202.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  10. Identification of TROP2 (TACSTD2), an EpCAM-like molecule, as a specific marker for TGF-beta1-dependent human epidermal Langerhans cells.
    Authors: Eisenwort G, Jurkin J, Yasmin N, Bauer T, Gesslbauer B, Strobl H
    J. Invest. Dermatol., 2011;131(10):2049-57.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry


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