Mouse TROP-2 Antibody
Mouse TROP-2 Antibody Summary
Ser82-Thr268
Accession # Q8BGV3
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Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Data Examples
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Detection of TROP‑2 in mIMCD-3 Mouse Cell Line by Flow Cytometry. mIMCD-3 mouse epithelial cell line was stained with Goat Anti-Mouse TROP-2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1122, filled histogram) or isotype control antibody (Catalog # AB-108-C, open histogram), followed by Allophycocyanin-conjugated Anti-Goat IgG Secondary Antibody (Catalog # F0108).
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TROP‑2 in XB2 Mouse Cell Line. TROP-2 was detected in immersion fixed XB2 mouse teratoma keratinocyte cell line using Goat Anti-Mouse TROP-2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1122) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (yellow; Catalog # NL001) and counterstained with DAPI (blue). View our protocol for Fluorescent ICC Staining of Cells on Coverslips.
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TROP‑2 in Mouse Skin. TROP-2 was detected in immersion fixed paraffin-embedded sections of mouse skin using Goat Anti-Mouse TROP-2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1122) at 3 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Goat IgG VisUCyte™ HRP Polymer Antibody (Catalog # VC004). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to cell membranes in keratinocytes. View our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: TROP-2
TROP-2, also named tumor-associated calcium signal transducer 2 (TACSTD2), GA733 tumor associated antigen, and epithelial glycoprotein-1 (EGP-1), is a type I transmembrane protein highly expressed in carcinomas. It was originally identified as an antigen present on human gastrointestinal tumors and is the second of two members of this family. The other family member is GA7332, also called EpCAM, TROP1, 171A, gp40 and KSA. TROP2 can transduce an intracellular calcium signal and may play a role in tumor growth. It also has adhesive functions.
Product Datasheets
Citations for Mouse TROP-2 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 10
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Hypoxia-mediated stabilization of HIF1A in prostatic intraepithelial neoplasia promotes cell plasticity and malignant progression
Authors: MA Abu El Maa, J Terzic, C Keime, D Rovito, R Lutzing, D Yanushko, M Parisotto, E Grelet, IJ Namer, V Lindner, G Laverny, D Metzger
Science Advances, 2022;8(29):eabo2295.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Ribosome impairment regulates intestinal stem cell identity via ZAK? activation
Authors: J Silva, F Alkan, S Ramalho, G Snieckute, S Prekovic, AK Garcia, S Hernández-, R van der Ka, D Barnum, L Hoekman, M Altelaar, W Zwart, SJE Suijkerbui, S Bekker-Jen, WJ Faller
Nature Communications, 2022;13(1):4492.
Species: Mouse
Sample Types: Organoid
Applications: IHC -
High-Throughput Drug Screening Identifies a Potent Wnt Inhibitor that Promotes Airway Basal Stem Cell Homeostasis
Authors: CJ Aros, MK Paul, CJ Pantoja, B Bisht, LK Meneses, P Vijayaraj, JM Sandlin, B France, JA Tse, MW Chen, DW Shia, TM Rickabaugh, R Damoiseaux, BN Gomperts
Cell Rep, 2020;30(7):2055-2064.e5.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Relief of tumor hypoxia unleashes the tumoricidal potential of neutrophils
Authors: K Mahiddine, A Blaisdell, S Ma, A Créquer-Gr, CA Lowell, A Erlebacher
J. Clin. Invest., 2019;0(0):.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-P -
Submucosal Gland Myoepithelial Cells Are Reserve Stem Cells That Can Regenerate Mouse Tracheal Epithelium
Authors: TJ Lynch, PJ Anderson, PG Rotti, SR Tyler, AK Crooke, SH Choi, DT Montoro, CL Silverman, W Shahin, R Zhao, CW Jensen-Cod, A Adamcakova, TIA Evans, W Xie, Y Zhang, H Mou, BP Herring, PS Thorne, J Rajagopal, C Yeaman, KR Parekh, JF Engelhardt
Cell Stem Cell, 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: ICC -
YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration
Authors: S Yui, L Azzolin, M Maimets, MT Pedersen, RP Fordham, SL Hansen, HL Larsen, J Guiu, MRP Alves, CF Rundsten, JV Johansen, Y Li, CD Madsen, T Nakamura, M Watanabe, OH Nielsen, PJ Schweiger, S Piccolo, KB Jensen
Cell Stem Cell, 2018;22(1):35-49.e7.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Maternal Fat Feeding Augments Offspring Nephron Endowment in Mice
PLoS ONE, 2016;11(8):e0161578.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-Fr -
Pten Regulates Epithelial Cytodifferentiation during Prostate Development.
Authors: Lokody I, Francis J, Gardiner J, Erler J, Swain A
PLoS ONE, 2015;10(6):e0129470.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-P -
Nrf2 enhances cholangiocyte expansion in Pten-deficient livers.
Authors: Taguchi, Keiko, Hirano, Ikuo, Itoh, Tohru, Tanaka, Minoru, Miyajima, Atsushi, Suzuki, Akira, Motohashi, Hozumi, Yamamoto, Masayuki
Mol Cell Biol, 2014;34(5):900-13.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Hepatocytes, rather than cholangiocytes, can be the major source of primitive ductules in the chronically injured mouse liver.
Authors: Sekiya S, Suzuki A
Am J Pathol, 2014;184(5):1468-78.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Global quantification of tissue dynamics in the developing mouse kidney.
Authors: Short K, Combes A, Lefevre J, Ju A, Georgas K, Lamberton T, Cairncross O, Rumballe B, McMahon A, Hamilton N, Smyth I, Little M
Dev Cell, 2014;29(2):188-202.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Identification of TROP2 (TACSTD2), an EpCAM-like molecule, as a specific marker for TGF-beta1-dependent human epidermal Langerhans cells.
Authors: Eisenwort G, Jurkin J, Yasmin N, Bauer T, Gesslbauer B, Strobl H
J. Invest. Dermatol., 2011;131(10):2049-57.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry
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