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Mouse VEGF Quantikine ELISA Kit, 2 Plate

91 citations
  • Assay Type
    Solid Phase Sandwich ELISA
  • Format
    96-well strip plate
  • Assay Length
    4.5 hours
  • Sensitivity
    3 pg/mL
  • Assay Range
    7.80 - 500 pg/mL (Cell Culture Supernates, Tissue Homogenates, Serum, EDTA Plasma,)
  • Specificity
    This kit recognizes both the 164 and 120 amino acid residue forms of mouse VEGF
  • Cross-reactivity
    < 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
  • Interference
    Interference observed with 1 or more available related molecules.
Product Summary
The Quantikine Mouse VEGF Immunoassay is a 4.5 hour solid phase ELISA designed to measure mouse VEGF in cell culture supernates, tissue homogenates, mouse serum, and plasma. It contains Sf 21-expressed mouse VEGF and antibodies raised against the recombinant factor. This immunoassay has been shown to quantitate the recombinant mouse VEGF accurately. Results obtained using natural mouse VEGF showed dose-response curves that were parallel to the standard curves obtained using the recombinant Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural mouse VEGF.

Precision
Intra-Assay Precision (Precision within an assay) Three samples of known concentration were tested in separate assays to assess inter-assay precision.
Inter-Assay Precision (Precision between assays Three samples of known concentration were tested on one plate to assess intra-assay precision.
Cell Culture Supernates, Tissue Homogenates, Serum, EDTA Plasma
Intra-Assay Precision Inter-Assay Precision
Sample123123
n202020202020
Mean37.714427738.3138291
Standard Deviation3.16.212.93.27.818.5
CV%8.24.34.78.45.76.4

Recovery

The recovery of mouse VEGF spiked to three levels throughout the range of the assay in various matrices was evaluated.

Sample Type Average % Recovery Range %
Cell Culture Supernates (n=9) 103 95-114
EDTA Plasma (n=5) 91 82-103
Heparin Plasma (n=4) 89 87-94
Serum (n=9) 101 83-115
Tissue Homogenates (n=3) 91 76-107
Linearity
To assess the linearity of the assay, samples containing and/or spiked with various concentrations of mouse VEGF in each matrix were diluted with Calibrator Diluent and then assayed.
VEGF_MMV00_ELISA_298.jpg
Background: Vascular Endothelial Growth Factor

Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF) or vasculotropin, is a homodimeric 34 - 42 kDa, heparin-binding glycoprotein with potent angiogenic, mitogenic and vascular permeability-enhancing activities specific for endothelial cells. The amino acid sequence of VEGF exhibits primary structural, as well as limited amino acid sequence, homology with that of the A and B chains of PDGF. All eight cysteine residues involved in intra- and inter-chain disulfide bonds are conserved among these growth factors. A cDNA encoding a protein having a 53% amino acid sequence homology in the PDGF-like region of VEGF has been isolated from a human placental cDNA library. This protein, named placenta growth factor (PlGF), is now recognized to be a member of the VEGF family of growth factors. Based on its homology with VEGF, PlGF was also proposed to be an angiogenic factor. Two receptor tyrosine kinases have been described as putative VEGF receptors. Flt-1 (fms-like tyrosine kinase), and KDR (kinase-insert-domain-containing receptor) proteins have been shown to bind VEGF with high affinity.

In vitro, VEGF is a potent endothelial cell mitogen. In cultured endothelial cells, VEGF can activate phospholipase C and induce rapid increases of free cytosolic Ca2+. VEGF has been shown to stimulate von Willebrand factor release from endothelial cells and induce expression of tissue factor activity in endothelial cells as well as in monocytes. VEGF has also been shown to be chemotactic for monocytes and osteoblasts. In vivo, VEGF can induce angiogenesis as well as increase microvascular permeability. As a vascular permeability factor, VEGF acts directly on the endothelium and does not degranulate mast cells. It promotes extravasation of plasma fibrinogen, leading to fibrin deposition which alters the tumor extracellular matrix. The modified extracellular matrix subsequently promotes the migration of macrophages, fibroblasts and endothelial cells. Based on its in vitro and in vivo properties, VEGF is expected to play important roles in inflammation and during normal and pathological angiogenesis, a process that is associated with wound healing, embryonic development, and growth and metastasis of solid tumors. Elevated levels of VEGF have been reported in synovial fluids of rheumatoid arthritis patients and in sera from cancer patients.

    Related Research Areas
    Assay Procedure
    Refer to the product for complete assay procedure.

    Bring all reagents and samples to room temperature before use. It is recommended that all samples, standards, and controls be assayed in duplicate.
    1.   Prepare all reagents, standard dilutions, and samples as directed in the product insert.
    2.   Remove excess microplate strips from the plate frame, return them to the foil pouch containing the desiccant pack, and reseal.

    3. 50 µL Assay Diluent
    4.   Add 50 µL of Assay Diluent to each well.

    5. 50 µL Standard, Control, or Sample
    6.   Add 50 µL of Standard, Control, or sample to each well. Cover with a plate sealer, and incubate at room temperature for 2 hours.
    7.   Aspirate each well and wash, repeating the process 4 times for a total of 5 washes.

    8. 100 µL Conjugate
    9.   Add 100 µL of Conjugate to each well. Cover with a new plate sealer, and incubate at room temperature for 2 hours.
    10.   Aspirate and wash 5 times.

    11. 100 µL Substrate Solution
    12.   Add 100 µL Substrate Solution to each well. Incubate at room temperature for 30 minutes. PROTECT FROM LIGHT.

    13. 100 µL Stop Solution
    14.   Add 100 µL of Stop Solution to each well. Read at 450 nm within 30 minutes. Set wavelength correction to 540 nm or 570 nm.
    Citations:

    R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

    Showing Results 1 - 10 of 91
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    Applications
    1. Long-chain fatty acid analogues suppress breast tumorigenesis and progression.
      Authors: Gluschnaider U, Hertz R, Ohayon S, Smeir E, Smets M, Pikarsky E, Bar-Tana J
      Cancer Res, 2014;74(23):6991-7002.
      Species: Mouse
      Sample Type: Tissue Lysate
    2. Cilostazol improves the response to ischemia in diabetic mice by a mechanism dependent on PPARgamma.
      Authors: Biscetti F, Pecorini G, Arena V, Stigliano E, Angelini F, Ghirlanda G, Ferraccioli G, Flex A
      Mol Cell Endocrinol, 2013;381(1):80-7.
      Species: Mouse
      Sample Type: Tissue Homogenates
    3. Anthocyanin-rich purple corn extract inhibit diabetes-associated glomerular angiogenesis.
      Authors: Kang M, Lim S, Lee J, Yeo K, Kang Y
      PLoS ONE, 2013;8(11):e79823.
      Species: Mouse
      Sample Type: Plasma
    4. Inhibitory effect of the combination therapy of simvastatin and pinocembrin on atherosclerosis in ApoE-deficient mice.
      Authors: Sang, Hui, Yuan, Na, Yao, Shutong, Li, Furong, Wang, Jiafu, Fang, Yongqi, Qin, Shucun
      Lipids Health Dis, 2012;11(0):166.
      Species: Mouse
      Sample Type: Serum
    5. TIEG1 inhibits breast cancer invasion and metastasis by inhibition of epidermal growth factor receptor (EGFR) transcription and the EGFR signaling pathway.
      Authors: Jin W, Chen BB, Li JY, Zhu H, Huang M, Gu SM, Wang QQ, Chen JY, Yu S, Wu J, Shao ZM
      Mol. Cell. Biol., 2012;32(1):50-63.
      Species: Mouse
      Sample Type: Serum
    6. HIF-VEGF pathways are critical for chronic otitis media in Junbo and Jeff mouse mutants.
      Authors: Cheeseman MT, Tyrer HE, Williams D, Hough TA, Pathak P, Romero MR, Hilton H, Bali S, Parker A, Vizor L, Purnell T, Vowell K, Wells S, Bhutta MF, Potter PK, Brown SD
      PLoS Genet., 2011;7(10):e1002336.
    7. Conditional HIF-1 induction produces multistage neovascularization with stage-specific sensitivity to VEGFR inhibitors and myeloid cell independence.
      Authors: Oladipupo SS, Hu S, Santeford AC, Yao J, Kovalski JR, Shohet RV, Maslov K, Wang LV, Arbeit JM
      Blood, 2011;117(15):4142-53.
      Species: Human
      Sample Type: Plasma
    8. Ocular neovascularization caused by herpes simplex virus type 1 infection results from breakdown of binding between vascular endothelial growth factor A and its soluble receptor.
      Authors: Suryawanshi A, Mulik S, Sharma S
      J. Immunol., 2011;186(6):3653-65.
      Species: Mouse
      Sample Type: Tissue Homogenates
    9. Placental growth factor mediates aldosterone-dependent vascular injury in mice.
      Authors: Jaffe IZ, Newfell BG, Aronovitz M
      J. Clin. Invest., 2010;120(11):3891-900.
      Species: Mouse
      Sample Type: Tissue Homogenates
    10. Effect of aromatase inhibitors on ectopic endometrial growth and peritoneal environment in a mouse model of endometriosis.
      Authors: Bilotas M, Meresman G, Stella I, Sueldo C, Baranao RI
      Fertil. Steril., 2010;93(8):2513-8.
      Species: Mouse
      Sample Type: Peritoneal Fluid
    11. Platelet-derived growth factor-B normalizes micromorphology and vessel function in vascular endothelial growth factor-A-induced squamous cell carcinomas.
      Authors: Lederle W, Linde N, Heusel J, Bzyl J, Woenne EC, Zwick S, Skobe M, Kiessling F, Fusenig NE, Mueller MM
      Am. J. Pathol., 2010;176(2):981-94.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    12. Small-molecule inhibitors of vascular adhesion protein-1 reduce the accumulation of myeloid cells into tumors and attenuate tumor growth in mice.
      Authors: Marttila-Ichihara F, Castermans K, Auvinen K, oude Egbrink MG, Jalkanen S, Griffioen AW, Salmi M
      J. Immunol., 2010;184(6):3164-73.
      Species: Mouse
      Sample Type: Serum
    13. Kallidinogenase normalizes retinal vasopermeability in streptozotocin-induced diabetic rats: potential roles of vascular endothelial growth factor and nitric oxide.
      Authors: Kato N, Hou Y, Lu Z, Lu C, Nagano H, Suzuma K, Takagi H, Matsumoto Y
      Eur. J. Pharmacol., 2009;606(1):187-90.
      Species: Mouse
      Sample Type: ocular fluid
    14. (Pro)renin receptor promotes choroidal neovascularization by activating its signal transduction and tissue renin-angiotensin system.
      Authors: Satofuka S, Ichihara A, Nagai N, Noda K, Ozawa Y, Fukamizu A, Tsubota K, Itoh H, Oike Y, Ishida S
      Am. J. Pathol., 2008;173(6):1911-8.
    15. Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand.
      Authors: Heissig B, Hattori K, Dias S, Friedrich M, Ferris B, Hackett NR, Crystal RG, Besmer P, Lyden D, Moore MA, Werb Z, Rafii S
      Cell, 2002;109(5):625-37.
      Species: Mouse
      Sample Type: Plasma
    16. Functions of type II pneumocyte-derived vascular endothelial growth factor in alveolar structure, acute inflammation, and vascular permeability.
      Authors: Mura M, Binnie M, Han B, Li C, Andrade CF, Shiozaki A, Zhang Y, Ferrara N, Hwang D, Waddell TK, Keshavjee S, Liu M
      Am. J. Pathol., 2010;176(4):1725-34.
    17. Short-term effects of pharmacologic HIF stabilization on vasoactive and cytotrophic factors in developing mouse brain.
      Authors: Schneider C, Krischke G, Keller S, Walkinshaw G, Arend M, Rascher W, Gassmann M, Trollmann R
      Brain Res., 2009;1280(0):43-51.
      Species: Mouse
      Sample Type: Serum
    18. Multiple circulating proangiogenic factors induced by sunitinib malate are tumor-independent and correlate with antitumor efficacy.
      Authors: Ebos JM, Lee CR, Christensen JG, Mutsaers AJ, Kerbel RS
      Proc. Natl. Acad. Sci. U.S.A., 2007;104(43):17069-74.
      Species: Mouse
      Sample Type: Plasma
    19. Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2.
      Authors: Takeda K, Ho VC, Takeda H, Duan LJ, Nagy A, Fong GH
      Mol. Cell. Biol., 2006;26(22):8336-46.
      Species: Mouse
      Sample Type: Tissue Homogenates
    20. VEGF receptor inhibition slows the progression of polycystic kidney disease.
      Authors: Tao Y, Kim J, Yin Y, Zafar I, Falk S, He Z, Faubel S, Schrier RW, Edelstein CL
      Kidney Int., 2007;72(11):1358-66.
    21. MicroRNAs regulate ocular neovascularization.
      Authors: Shen J, Yang X, Xie B, Chen Y, Swaim M, Hackett SF, Campochiaro PA
      Mol. Ther., 2008;16(7):1208-16.
      Species: Mouse
      Sample Type: Tissue Homogenates
    22. von Hippel-Lindau mutation in mice recapitulates Chuvash polycythemia via hypoxia-inducible factor-2alpha signaling and splenic erythropoiesis.
      Authors: Hickey MM, Lam JC, Bezman NA, Rathmell WK, Simon MC
      J. Clin. Invest., 2007;117(12):3879-3889.
    23. The aryl hydrocarbon receptor (AhR) inhibits vanadate-induced vascular endothelial growth factor (VEGF) production in TRAMP prostates.
      Authors: Fritz WA, Lin TM, Peterson RE
      Carcinogenesis, 2008;29(5):1077-82.
      Species: Mouse
      Sample Type: Tissue Homogenates
    24. Regulation of scar formation by vascular endothelial growth factor.
      Authors: Wilgus TA, Ferreira AM, Oberyszyn TM, Bergdall VK, DiPietro LA
      Lab. Invest., 2008;88(6):579-90.
      Species: Mouse
      Sample Type: Tissue Homogenates
    25. Targeted deletion of CCR2 impairs deep vein thombosis resolution in a mouse model.
      Authors: Henke PK, Pearce CG, Moaveni DM, Moore AJ, Lynch EM, Longo C, Varma M, Dewyer NA, Deatrick KB, Upchurch GR, Wakefield TW, Hogaboam C, Kunkel SL
      J. Immunol., 2006;177(5):3388-97.
      Species: Mouse
      Sample Type: Tissue Homogenates
    26. Inactivation of VEGF in mammary gland epithelium severely compromises mammary gland development and function.
      Authors: Rossiter H, Barresi C, Ghannadan M, Gruber F, Mildner M, Fodinger D, Tschachler E
      FASEB J., 2007;21(14):3994-4004.
      Species: Mouse
      Sample Type: Milk
    27. Short-term dietary administration of celecoxib enhances the efficacy of tumor lysate-pulsed dendritic cell vaccines in treating murine breast cancer.
      Authors: Hahn T, Alvarez I, Kobie JJ, Ramanathapuram L, Dial S, Fulton A, Besselsen D, Walker E, Akporiaye ET
      Int. J. Cancer, 2006;118(9):2220-31.
      Species: Mouse
      Sample Type: Serum
    28. Increased VEGF levels induced by anti-VEGF treatment are independent of tumor burden in colorectal carcinomas in mice.
      Authors: Schmitz V, Vilanueva H, Raskopf E, Hilbert T, Barajas M, Dzienisowicz C, Gorschluter M, Strehl J, Rabe C, Sauerbruch T, Prieto J, Caselmann WH, Qian C
      Gene Ther., 2006;13(16):1198-205.
    29. Recombinant adeno-associated virus 2-mediated antiangiogenic prevention in a mouse model of intraperitoneal ovarian cancer.
      Authors: Isayeva T, Ren C, Ponnazhagan S
      Clin. Cancer Res., 2005;11(3):1342-7.
      Species: Mouse
      Sample Type: Ascites
    30. Albendazole: a potent inhibitor of vascular endothelial growth factor and malignant ascites formation in OVCAR-3 tumor-bearing nude mice.
      Authors: Pourgholami MH, Yan Cai Z, Lu Y, Wang L, Morris DL
      Clin. Cancer Res., 2006;12(6):1928-35.
    31. Effect of valsartan versus lisinopril on peritoneal sclerosis in rats.
      Authors: Duman S, Sen S, Duman C, Oreopoulos DG
      Int J Artif Organs, 2005;28(2):156-63.
      Species: Rat
      Sample Type: Peritoneal Dialysate
    32. Marked inhibition of retinal neovascularization in rats following soluble-flt-1 gene transfer.
      Authors: Rota R, Riccioni T, Zaccarini M, Lamartina S, Gallo AD, Fusco A, Kovesdi I, Balestrazzi E, Abeni DC, Ali RR, Capogrossi MC
      J Gene Med, 2004;6(9):992-1002.
      Species: Rat
      Sample Type: Vitreous Humor
    33. Nuclear factor-kappaB affects tumor progression in a mouse model of malignant pleural effusion.
      Authors: Stathopoulos GT, Zhu Z, Everhart MB, Kalomenidis I, Lawson WE, Bilaceroglu S, Peterson TE, Mitchell D, Yull FE, Light RW, Blackwell TS
      Am. J. Respir. Cell Mol. Biol., 2005;34(2):142-50.
    34. Expression of pulmonary VEGF family declines with age and is further down-regulated in lipopolysaccharide (LPS)-induced lung injury.
      Authors: Ito Y, Betsuyaku T, Nagai K, Nasuhara Y, Nishimura M
      Exp. Gerontol., 2005;40(4):315-23.
      Species: Mouse
      Sample Type: BALF
    35. HIF-1alpha induced-VEGF overexpression in bone marrow stem cells protects cardiomyocytes against ischemia.
      Authors: Dai Y, Xu M, Wang Y, Pasha Z, Li T, Ashraf M
      J. Mol. Cell. Cardiol., 2007;42(6):1036-44.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    36. beta-Catenin regulates vascular endothelial growth factor expression in colon cancer.
      Authors: Easwaran V, Lee SH, Inge L, Guo L, Goldbeck C, Garrett E, Wiesmann M, Garcia PD, Fuller JH, Chan V, Randazzo F, Gundel R, Warren RS, Escobedo J, Aukerman SL, Taylor RN, Fantl WJ
      Cancer Res., 2003;63(12):3145-53.
    37. The human herpes virus 8-encoded chemokine receptor is required for angioproliferation in a murine model of Kaposi's sarcoma.
      Authors: Jensen KK, Manfra DJ, Grisotto MG, Martin AP, Vassileva G, Kelley K, Schwartz TW, Lira SA
      J. Immunol., 2005;174(6):3686-94.
      Species: Mouse
      Sample Type: Tissue Homogenates
    38. Gene transfer of transforming growth factor-beta1 to the rat peritoneum: effects on membrane function.
      Authors: Margetts PJ, Kolb M, Galt T, Hoff CM, Shockley TR, Gauldie J
      J. Am. Soc. Nephrol., 2001;12(10):2029-39.
    39. Enteric bacteria and their antigens may stimulate postoperative peritoneal adhesion formation.
      Authors: Cahill RA, Wang JH, Redmond HP
      Surgery, 2007;141(3):403-10.
    40. alpha2beta1 integrin expression in the tumor microenvironment enhances tumor angiogenesis in a tumor cell-specific manner.
      Authors: Zhang Z, Ramirez NE, Yankeelov TE, Li Z, Ford LE, Qi Y, Pozzi A, Zutter MM
      Blood, 2007;111(4):1980-8.
    41. Effects of sustained antiangiogenic therapy in multistage prostate cancer in TRAMP model.
      Authors: Isayeva T, Chanda D, Kallman L, Eltoum IE, Ponnazhagan S
      Cancer Res., 2007;67(12):5789-97.
      Species: Mouse
      Sample Type: Serum
    42. Enalapril increases ischemia-induced endothelial progenitor cell mobilization through manipulation of the CD26 system.
      Authors: Wang CH, Verma S, Hsieh IC, Chen YJ, Kuo LT, Yang NI, Wang SY, Wu MY, Hsu CM, Cheng CW, Cherng WJ
      J. Mol. Cell. Cardiol., 2006;41(1):34-43.
      Species: Mouse
      Sample Type: Plasma
    43. Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death.
      Authors: Bhandari V, Choo-Wing R, Lee CG, Zhu Z, Nedrelow JH, Chupp GL, Zhang X, Matthay MA, Ware LB, Homer RJ, Lee PJ, Geick A, de Fougerolles AR, Elias JA
      Nat. Med., 2006;12(11):1286-93.
      Species: Mouse
      Sample Type: BALF
    44. Antibodies to vascular endothelial growth factor enhance the efficacy of cancer immunotherapy by improving endogenous dendritic cell function.
      Authors: Gabrilovich DI, Ishida T, Nadaf S, Ohm JE, Carbone DP
      Clin. Cancer Res., 1999;5(10):2963-70.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    45. mTORC1 and mTORC2 play different roles in the functional survival of transplanted adipose-derived stromal cells in hind limb ischemic mice via regulating inflammation in vivo.
      Authors: Fan W, Cheng K, Qin X, Narsinh K, Wang S, Hu S, Wang Y, Chen Y, Wu J, Xiong L, Cao F
      Stem Cells, 2013;31(1):203-14.
    46. Apricoxib, a novel inhibitor of COX-2, markedly improves standard therapy response in molecularly defined models of pancreatic cancer.
      Clin. Cancer Res., 2012;18(18):5031-42.
    47. Hypoxia-inducible Factor-1 (HIF-1) but Not HIF-2 Is Essential for Hypoxic Induction of Collagen Prolyl 4-Hydroxylases in Primary Newborn Mouse Epiphyseal Growth Plate Chondrocytes.
      Authors: Aro E, Khatri R
      J. Biol. Chem., 2012;287(44):37134-44.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    48. Anti-angiogenic effect of metformin in mouse oxygen-induced retinopathy is mediated by reducing levels of the vascular endothelial growth factor receptor Flk-1.
      Authors: Joe, Soo Geun, Yoon, Young He, Choi, Jeong A, Koh, Jae-Youn
      PLoS ONE, 2015;10(3):e0119708.
      Species: Mouse
      Sample Type: Tissue Homogenates
    49. Rapid chemotherapy-induced acute endothelial progenitor cell mobilization: implications for antiangiogenic drugs as chemosensitizing agents.
      Authors: Shaked Y, Henke E, Roodhart JM, Mancuso P, Langenberg MH, Colleoni M, Daenen LG, Man S, Xu P, Emmenegger U, Tang T, Zhu Z, Witte L, Strieter RM, Bertolini F, Voest EE, Benezra R, Kerbel RS
      Cancer Cell, 2008;14(3):263-73.
      Species: Mouse
      Sample Type: Plasma
    50. Placenta growth factor in diabetic wound healing: altered expression and therapeutic potential.
      Authors: Cianfarani F, Zambruno G, Brogelli L, Sera F, Lacal PM, Pesce M, Capogrossi MC, Failla CM, Napolitano M, Odorisio T
      Am. J. Pathol., 2006;169(4):1167-82.
      Species: Mouse
      Sample Type: Tissue Homogenates
    51. Deficiency of immunophilin FKBP52 promotes endometriosis.
      Authors: Hirota Y, Tranguch S, Daikoku T, Hasegawa A, Osuga Y, Taketani Y, Dey SK
      Am. J. Pathol., 2008;173(6):1747-57.
      Species: Mouse
      Sample Type: Peritoneal Fluid
    52. Soluble vascular endothelial growth factor receptor-1 protects mice in sepsis.
      Authors: Tsao PN, Chan FT, Wei SC, Hsieh WS, Chou HC, Su YN, Chen CY, Hsu WM, Hsieh FJ, Hsu SM
      Crit. Care Med., 2007;35(8):1955-60.
      Species: Mouse
      Sample Type: Plasma
    53. Adeno-associated virus vector-mediated delivery of pigment epithelium-derived factor restricts neuroblastoma angiogenesis and growth.
      Authors: Streck CJ, Zhang Y, Zhou J, Ng C, Nathwani AC, Davidoff AM
      J. Pediatr. Surg., 2005;40(1):236-43.
    54. Heme oxygenase-1 promotes neovascularization in ischemic heart by coinduction of VEGF and SDF-1.
      Authors: Lin HH, Chen YH, Chang PF, Lee YT, Yet SF, Chau LY
      J. Mol. Cell. Cardiol., 2008;45(1):44-55.
      Species: Mouse
      Application: TSample Type: Tissue Homogenates
    55. A GMCSF and IL-15 fusokine leads to paradoxical immunosuppression in vivo via asymmetrical JAK/STAT signaling through the IL-15 receptor complex.
      Authors: Rafei M, Wu JH, Annabi B, Lejeune L, Francois M, Galipeau J
      Blood, 2007;109(5):2234-42.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    56. Effects of increased renal tubular vascular endothelial growth factor (VEGF) on fibrosis, cyst formation, and glomerular disease.
      Authors: Hakroush S, Moeller MJ, Theilig F, Kaissling B, Sijmonsma TP, Jugold M, Akeson AL, Traykova-Brauch M, Hosser H, Hahnel B, Grone HJ, Koesters R, Kriz W
      Am. J. Pathol., 2009;175(5):1883-95.
      Species: Mouse
      Sample Type: Serum
    57. Very low density lipoprotein receptor, a negative regulator of the wnt signaling pathway and choroidal neovascularization.
      Authors: Chen Y, Hu Y, Lu K, Flannery JG, Ma JX
      J. Biol. Chem., 2007;282(47):34420-8.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    58. Hydroxylase inhibition abrogates TNF-alpha-induced intestinal epithelial damage by hypoxia-inducible factor-1-dependent repression of FADD.
      Authors: Hindryckx P, De Vos M, Jacques P, Ferdinande L, Peeters H, Olievier K, Bogaert S, Brinkman B, Vandenabeele P, Elewaut D, Laukens D
      J. Immunol., 2010;185(10):6306-16.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    59. Role of Tim-3/galectin-9 inhibitory interaction in viral-induced immunopathology: shifting the balance toward regulators.
      Authors: Sehrawat S, Suryawanshi A, Hirashima M, Rouse BT
      J. Immunol., 2009;182(5):3191-201.
      Species: Mouse
      Sample Type: Tissue Homogenates
    60. Macular pigment lutein is antiinflammatory in preventing choroidal neovascularization.
      Authors: Izumi-Nagai K, Nagai N, Ohgami K, Satofuka S, Ozawa Y, Tsubota K, Umezawa K, Ohno S, Oike Y, Ishida S
      Arterioscler. Thromb. Vasc. Biol., 2007;27(12):2555-62.
    61. Chemokine receptor CX3CR1 mediates skin wound healing by promoting macrophage and fibroblast accumulation and function.
      Authors: Ishida Y, Gao JL, Murphy PM
      J. Immunol., 2008;180(1):569-79.
      Species: Mouse
      Sample Type: Tissue Homogenates
    62. Hypoxia-induced mitogenic factor has proangiogenic and proinflammatory effects in the lung via VEGF and VEGF receptor-2.
      Authors: Yamaji-Kegan K, Su Q, Angelini DJ, Champion HC, Johns RA
      Am. J. Physiol. Lung Cell Mol. Physiol., 2006;291(6):L1159-68.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    63. Varying susceptibility of pulmonary cytokine production to lipopolysaccharide in mice.
      Authors: Alm AS, Li K, Yang D, Andersson R, Lu Y, Wang X
      Cytokine, 2010;49(3):256-63.
      Species: Mouse
      Sample Type: BALF
    64. Disruption of interleukin-1 signaling improves the quality of wound healing.
      Authors: Thomay AA, Daley JM, Sabo E, Worth PJ, Shelton LJ, Harty MW, Reichner JS, Albina JE
      Am. J. Pathol., 2009;174(6):2129-36.
      Species: Mouse
      Sample Type: wound fluid
    65. Antimycotic ciclopirox olamine in the diabetic environment promotes angiogenesis and enhances wound healing.
      Authors: Ko SH, Nauta A, Morrison SD, Zhou H, Zimmermann A, Gurtner GC, Ding S, Longaker MT
      PLoS ONE, 2011;6(11):e27844.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    66. An Adam15 amplification loop promotes vascular endothelial growth factor-induced ocular neovascularization.
      Authors: Xie B, Shen J, Dong A, Swaim M, Hackett SF, Wyder L, Worpenberg S, Barbieri S, Campochiaro PA
      FASEB J., 2008;22(8):2775-83.
      Species: Mouse
      Sample Type: Tissue Homogenates
    67. Mast cells facilitate local VEGF release as an early event in the pathogenesis of postoperative peritoneal adhesions.
      Authors: Cahill RA, Wang JH, Soohkai S, Redmond HP
      Surgery, 2006;140(1):108-12.
    68. Matrix-binding vascular endothelial growth factor (VEGF) isoforms guide granule cell migration in the cerebellum via VEGF receptor Flk1.
      Authors: Ruiz de Almodovar C, Coulon C, Salin PA, Knevels E, Chounlamountri N, Poesen K, Hermans K, Lambrechts D, Van Geyte K, Dhondt J, Dresselaers T, Renaud J, Aragones J, Zacchigna S, Geudens I, Gall D, Stroobants S, Mutin M, Dassonville K, Storkebaum E, Jordan BF, Eriksson U, Moons L, D'Hooge R, Haigh JJ, Belin MF, Schiffmann S, Van Hecke P, Gallez B, Vinckier S, Chedotal A, Honnorat J, Thomasset N, Carmeliet P, Meissirel C
      J. Neurosci., 2010;30(45):15052-66.
      Species: Mouse
      Sample Type: Tissue Homogenates
    69. Estrogen regulates the production of VEGF for osteoclast formation and activity in op/op mice.
      Authors: Kodama I, Sanada M, Yoshiko Y, Tsuda M, Ohama K
      J. Bone Miner. Res., 2004;19(2):200-6.
      Species: Mouse
      Sample Type: Serum
    70. Lack of alpha2-antiplasmin promotes pulmonary heart failure via overrelease of VEGF after acute myocardial infarction.
      Authors: Kozawa O, Yoshimi N, Akamatsu S, Hara A, Mori H, Uematsu T
      Blood, 2002;100(7):2487-93.
    71. Combination of systemic thioacetamide (TAA) injections and ethanol feeding accelerates hepatic fibrosis in C3H/He mice and is associated with intrahepatic up regulation of MMP-2, VEGF and ICAM-1.
      Authors: Kornek M, Raskopf E, Guetgemann I, Ocker M, Gerceker S, Gonzalez-Carmona MA, Rabe C, Sauerbruch T, Schmitz V
      J. Hepatol., 2006;45(3):370-6.
      Species: Mouse
      Sample Type: Tissue Homogenates
    72. Regulation of pathologic retinal angiogenesis in mice and inhibition of VEGF-VEGFR2 binding by soluble heparan sulfate.
      Authors: Nishiguchi KM, Kataoka K, Kachi S
      PLoS ONE, 2010;5(10):e13493.
      Species: Mouse
      Sample Type: ocular fluid
    73. Cathelicidin-deficient (Cnlp -/- ) mice show increased susceptibility to Pseudomonas aeruginosa keratitis.
      Authors: Huang LC, Reins RY, Gallo RL, McDermott AM
      Invest. Ophthalmol. Vis. Sci., 2007;48(10):4498-508.
      Species: Mouse
      Sample Type: Tissue Homogenates
    74. The Down syndrome critical region gene 1 short variant promoters direct vascular bed-specific gene expression during inflammation in mice.
      Authors: Minami T, Yano K, Miura M, Kobayashi M, Suehiro J, Reid PC, Hamakubo T, Ryeom S, Aird WC, Kodama T
      J. Clin. Invest., 2009;119(8):2257-70.
      Species: Mouse
      Sample Type: Plasma
    75. A critical role of placental growth factor in the induction of inflammation and edema formation.
      Authors: Oura H, Bertoncini J, Velasco P, Brown LF, Carmeliet P, Detmar M
      Blood, 2002;101(2):560-7.
      Species: Mouse
      Sample Type: Cell Lysates
    76. CCL2 regulates angiogenesis via activation of Ets-1 transcription factor.
      Authors: Stamatovic SM, Keep RF, Mostarica-Stojkovic M, Andjelkovic AV
      J. Immunol., 2006;177(4):2651-61.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    77. Cationic liposome coupled endostatin gene for treatment of peritoneal colon cancer.
      Authors: Lan KL, Ou-Yang F, Yen SH, Shih HL, Lan KH
      Clin. Exp. Metastasis, 2010;27(5):307-18.
    78. IL-17 and VEGF are necessary for efficient corneal nerve regeneration.
      Authors: Li Z, Burns AR, Han L, Rumbaut RE, Smith CW
      Am. J. Pathol., 2011;178(3):1106-16.
      Species: Mouse
      Sample Type: Tissue Homogenates
    79. Transgenic expression of human cathepsin B promotes progression and metastasis of polyoma-middle-T-induced breast cancer in mice.
      Authors: Sevenich L, Werner F, Gajda M, Schurigt U, Sieber C, Muller S, Follo M, Peters C, Reinheckel T
      Oncogene, 2011;30(1):54-64.
    80. Differential roles of vascular endothelial growth factor receptors 1 and 2 in dendritic cell differentiation.
      Authors: Dikov MM, Ohm JE, Ray N, Tchekneva EE, Burlison J, Moghanaki D, Nadaf S, Carbone DP
      J. Immunol., 2005;174(1):215-22.
    81. Recapitulation of pancreatic neuroendocrine tumors in human multiple endocrine neoplasia type I syndrome via Pdx1-directed inactivation of Men1.
      Authors: Shen HC, He M, Powell A, Adem A, Lorang D, Heller C, Grover AC, Ylaya K, Hewitt SM, Marx SJ, Spiegel AM, Libutti SK
      Cancer Res., 2009;69(5):1858-66.
      Species: Mouse
      Sample Type: Tissue Homogenates
    82. Role of peroxisome proliferator-activated receptor-alpha in acute pancreatitis induced by cerulein.
      Authors: Genovese T, Mazzon E, Di Paola R, Muia C, Crisafulli C, Malleo G, Esposito E, Cuzzocrea S
      Immunology, 2006;118(4):559-70.
      Species: Mouse
      Sample Type: Tissue Homogenates
    83. VEGF164(165) as the pathological isoform: differential leukocyte and endothelial responses through VEGFR1 and VEGFR2.
      Authors: Usui T, Ishida S, Yamashiro K, Kaji Y, Poulaki V, Moore J, Moore T, Amano S, Horikawa Y, Dartt D, Golding M, Shima DT, Adamis AP
      Invest. Ophthalmol. Vis. Sci., 2004;45(2):368-74.
      Species: Mouse
      Sample Type: Tissue Homogenates
    84. Relationship between complement membrane attack complex, chemokine (C-C motif) ligand 2 (CCL2) and vascular endothelial growth factor in mouse model of laser-induced choroidal neovascularization.
      Authors: Liu J, Jha P, Lyzogubov VV, Tytarenko RG, Bora NS, Bora PS
      J. Biol. Chem., 2011;286(23):20991-1001.
      Species: Mouse
      Sample Type: Tissue Homogenates
    85. Inhibition of choroidal neovascularization with an anti-inflammatory carotenoid astaxanthin.
      Authors: Izumi-Nagai K, Nagai N, Ohgami K, Satofuka S, Ozawa Y, Tsubota K, Ohno S, Oike Y, Ishida S
      Invest. Ophthalmol. Vis. Sci., 2008;49(4):1679-85.
      Species: Mouse
      Sample Type: Tissue Homogenates
    86. Inhibition of EGFR pathway signaling and the metastatic potential of breast cancer cells by PA-MSHA mediated by type 1 fimbriae via a mannose-dependent manner.
      Authors: Liu ZB, Hou YF, Zhu J
      Oncogene, 2010;29(20):2996-3009.
      Species: Mouse
      Sample Type: Serum
    87. Upregulation of VEGF in murine retina via monocyte recruitment after retinal scatter laser photocoagulation.
      Authors: Itaya M, Sakurai E, Nozaki M, Yamada K, Yamasaki S, Asai K, Ogura Y
      Invest. Ophthalmol. Vis. Sci., 2007;48(12):5677-83.
    88. Metastatic squamous cell carcinoma cells that overexpress c-Met exhibit enhanced angiogenesis factor expression, scattering and metastasis in response to hepatocyte growth factor.
      Authors: Dong G, Lee TL, Yeh NT, Geoghegan J, Van Waes C
      Oncogene, 2004;23(37):6199-208.
    89. VEGF-A produced by chronically inflamed tissue induces lymphangiogenesis in draining lymph nodes.
      Authors: Halin C, Tobler NE, Vigl B, Brown LF, Detmar M
      Blood, 2007;110(9):3158-67.
      Species: Mouse
      Sample Type: Tissue Homogenates
    90. High expression of ligands for chemokine receptor CXCR2 in alveolar epithelial neoplasia induced by oncogenic kras.
      Authors: Wislez M, Fujimoto N, Izzo JG, Hanna AE, Cody DD, Langley RR, Tang H, Burdick MD, Sato M, Minna JD, Mao L, Wistuba I, Strieter RM, Kurie JM
      Cancer Res., 2006;66(8):4198-207.
    91. Inhibitory effect of atractylenolide I on angiogenesis in chronic inflammation in vivo and in vitro.
      Authors: Wang C, Duan H, He L
      Eur. J. Pharmacol., 2009;612(1):143-52.
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