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MTT Cell Proliferation/Viability Assay

Catalog #: 4890-025-K
67 Citations Datasheet / COA / SDS
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4890-025-K
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MTT Cell Proliferation/Viability Assay Summary

MTT Cell Proliferation/Viability Assay

MTT can be used to safely assess cell proliferation, cell viability, and/or cytotoxicity. MTT is added directly to the culture medium and is reduced by metabolically active cells to insoluble purple formazan dye crystals. The absorbance of the sample is read directly in the wells at an optimal wavelength of 570 nm, but any filter that absorbs between 550 and 600 nm may be used.

Label: Tetrazolium compound MTT changes to from yellow to purple
Testing Format: Microplate reader
Sample Type: Cultured cells
Size: 25 x 96-well microplates

Specifications

Shipping Conditions
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Storage
The product requires storage at 2 - 8 °C and room temperature.  Consult the product insert for specific storage temperatures. Do not use past expiration date.

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Citations for MTT Cell Proliferation/Viability Assay

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

67 Citations: Showing 1 - 10
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  1. A 3D Collagen-Based Bioprinted Model to Study Osteosarcoma Invasiveness and Drug Response
    Authors: E Pellegrini, G Desando, M Petretta, A Cellamare, C Cristalli, M Pasello, MC Manara, B Grigolo, K Scotlandi
    Polymers, 2022-09-28;14(19):.  2022-09-28
  2. A patch of positively charged residues regulates the efficacy of clinical DR5 antibodies in solid tumors
    Authors: G Shivange, T Mondal, E Lyerly, S Bhatnagar, CN Landen, S Reddy, J Kim, B Doan, P Riddle, J Tushir-Sin
    Cell Reports, 2021-11-02;37(5):109953.  2021-11-02
  3. Poly(l-Lactic Acid)-co-poly(Butylene Adipate) New Block Copolymers for the Preparation of Drug-Loaded Long Acting Injectable Microparticles
    Authors: V Karava, A Siamidi, M Vlachou, E Christodou, ND Bikiaris, A Zamboulis, M Kostoglou, E Gounari, P Barmpalexi
    Pharmaceutics, 2021-06-23;13(7):.  2021-06-23
  4. Assembly and Function of a Bioengineered Human Liver for Transplantation Generated Solely from Induced Pluripotent Stem Cells
    Authors: K Takeishi, A Collin de, Y Wang, K Handa, J Guzman-Lep, K Matsubara, K Morita, S Jang, N Haep, RM Florentino, F Yuan, K Fukumitsu, K Tobita, W Sun, J Franks, ER Delgado, EM Shapiro, NA Fraunhoffe, AW Duncan, H Yagi, T Mashimo, IJ Fox, A Soto-Gutie
    Cell Rep, 2020-06-02;31(9):107711.  2020-06-02
  5. Indirubin-pregnane X receptor-JNK axis accelerates skin wound healing
    Authors: Y Tanaka, H Uchi, T Ito, M Furue
    Sci Rep, 2019-12-03;9(1):18174.  2019-12-03
  6. GLUT1 and TUBB4 in Glioblastoma Could be Efficacious Targets
    Authors: MR Guda, CM Labak, SI Omar, S Asuthkar, S Airala, J Tuszynski, AJ Tsung, KK Velpula
    Cancers (Basel), 2019-09-05;11(9):.  2019-09-05
  7. Tumor-associated macrophages modulate resistance to oxaliplatin via inducing autophagy in hepatocellular carcinoma
    Authors: XT Fu, K Song, J Zhou, YH Shi, WR Liu, GM Shi, Q Gao, XY Wang, ZB Ding, J Fan
    Cancer Cell Int., 2019-03-25;19(0):71.  2019-03-25
  8. Preventive Effect of the Herbal Preparation, HemoHIM, on Cisplatin-Induced Immune Suppression
    Authors: SK Kim, DA Kwon, HS Lee, HK Kim, WK Kim
    Evid Based Complement Alternat Med, 2019-03-20;2019(0):3494806.  2019-03-20
  9. Pioglitazone-Primed Mesenchymal Stem Cells Stimulate Cell Proliferation, Collagen Synthesis and Matrix Gene Expression in Tenocytes
    Authors: W Kim, SK Lee, YW Kwon, SG Chung, S Kim
    Int J Mol Sci, 2019-01-22;20(3):.  2019-01-22
  10. A genetically engineered microRNA-34a prodrug demonstrates anti-tumor activity in a canine model of osteosarcoma
    Authors: F Alegre, AR Ormonde, KM Snider, K Woolard, AM Yu, LA Wittenburg
    PLoS ONE, 2018-12-31;13(12):e0209941.  2018-12-31
  11. Plant-derived antiviral drugs as novel hepatitis B virus inhibitors: Cell culture and molecular docking study
    Authors: MK Parvez, M Tabish Reh, P Alam, MS Al-Dosari, SI Alqasoumi, MF Alajmi
    Saudi Pharm J, 2018-12-26;27(3):389-400.  2018-12-26
  12. Silk fibroin peptide suppresses proliferation and induces apoptosis and cell cycle arrest in human lung cancer cells
    Authors: MS Wang, YB Du, HM Huang, ZL Zhu, SS Du, SY Chen, HP Zhao, Z Yan
    Acta Pharmacol. Sin., 2018-06-19;0(0):.  2018-06-19
  13. Overexpressing microRNA-150 attenuates hypoxia-induced human cardiomyocyte cell apoptosis by targeting glucose-regulated protein-94
    Authors: JL Ma, WL Guo, XM Chen
    Mol Med Rep, 2018-01-05;0(0):.  2018-01-05
  14. Overexpressed microRNA-506 and microRNA-124 alleviate H2O2-induced human cardiomyocyte dysfunction by targeting kr�ppel-like factor 4/5
    Authors: X Zhang, F Liu, Q Wang, Y Geng
    Mol Med Rep, 2017-08-14;0(0):.  2017-08-14
  15. Histone demethylase PHF8 accelerates the progression of colorectal cancer and can be regulated by miR-488 in�vitro
    Authors: Y Lv, Y Shi, Q Han, G Dai
    Mol Med Rep, 2017-08-01;16(4):4437-4444.  2017-08-01
  16. A screen for inhibitory peptides of hepatitis C virus identifies a novel entry inhibitor targeting E1 and E2
    Authors: P Yin, L Zhang, F Ye, Y Deng, S Lu, YP Li, L Zhang, W Tan
    Sci Rep, 2017-06-21;7(1):3976.  2017-06-21
  17. miRNA?1271 inhibits cell proliferation in neuroglioma by targeting fibronectin 1
    Authors: J Gong, ZX Wang, ZY Liu
    Mol Med Rep, 2017-05-19;0(0):.  2017-05-19
  18. Synergistic effect of Ebselen and gamma radiation on breast cancer cells.
    Authors: Thabet N, Moustafa E
    Int J Radiat Biol, 2017-05-17;93(8):784-792.  2017-05-17
  19. Fusion expression of Occludin extracellular loops and an ?-helical bundle: A new research model for tight junction
    Authors: X Chi, X Zhao, W Wang, Y Niu, M Cheng, X Liu, S Cui, W Yang
    PLoS ONE, 2017-04-27;12(4):e0175516.  2017-04-27
  20. A functional screening of the kinome identifies the Polo-like kinase 4 as a potential therapeutic target for malignant rhabdoid tumors, and possibly, other embryonal tumors of the brain.
    Authors: Sredni S, Suzuki M, Yang J, Topczewski J, Bailey A, Gokirmak T, Gross J, de Andrade A, Kondo A, Piper D, Tomita T
    Pediatr Blood Cancer, 2017-04-11;64(11):.  2017-04-11
  21. An easy method for bacterial expression and purification of wild-type and mutant superoxide dismutase 1 (SOD1).
    Authors: Tachu B, Wusten K, Garza M, Wille H, Tamguney G
    Protein Expr Purif, 2017-04-03;134(0):63-71.  2017-04-03
  22. Comparison of electrospun and solvent cast polylactic acid (PLA)/poly(vinyl alcohol) (PVA) inserts as potential ocular drug delivery vehicles.
    Authors: Bhattarai R, Das A, Alzhrani R, Kang D, Bhaduri S, Boddu S
    Mater Sci Eng C Mater Biol Appl, 2017-04-01;77(0):895-903.  2017-04-01
  23. In vitro cytotoxicity assessment of a West Virginia chemical spill mixture involving 4-methylcyclohexanemethanol and propylene glycol phenyl ether.
    Authors: Han A, Fabyanic E, Miller J, Prediger M, Prince N, Mouch J, Boyd J
    Environ Monit Assess, 2017-03-29;189(4):190.  2017-03-29
  24. Development and qualification of an LC-MS/MS method for investigating the biological implications of micelle entrapped paclitaxel in cell culture and rats.
    Authors: Kaddoumi A, Gill K, Elfakhri K, Nazzal S
    Biomed Chromatogr, 2017-03-21;31(9):.  2017-03-21
  25. Can mesenchymal stem cells pretreated with platelet-rich plasma modulate tissue remodeling in a rat with burned skin?
    Authors: Hosni Ahmed H, Rashed L, Mahfouz S, Elsayed Hussein R, Alkaffas M, Mostafa S, Abusree A
    Biochem Cell Biol, 2017-03-17;95(5):537-548.  2017-03-17
  26. Anticancer and Anti-Inflammatory Properties of Ganoderma lucidum Extract Effects on Melanoma and Triple-Negative Breast Cancer Treatment.
    Authors: Barbieri A, Quagliariello V, Del Vecchio V, Falco M, Luciano A, Amruthraj N, Nasti G, Ottaiano A, Berretta M, Iaffaioli R, Arra C
    Nutrients, 2017-02-28;9(3):.  2017-02-28
  27. Lysophosphatidic Acid Triggers Apoptosis in HeLa Cells through the Upregulation of Tumor Necrosis Factor Receptor Superfamily Member 21
    Authors: Y Dong, Y Wu, MZ Cui, X Xu
    Mediators Inflamm., 2017-02-19;2017(0):2754756.  2017-02-19
  28. Mechanisms of Chinese Medicine Xinmailong's protection against heart failure in pressure-overloaded mice and cultured cardiomyocytes
    Authors: J Qi, J Yu, Y Tan, R Chen, W Xu, Y Chen, J Lu, Q Liu, J Wu, W Gu, M Zhang
    Sci Rep, 2017-02-16;7(0):42843.  2017-02-16
  29. Plasma Gelsolin Induced Glomerular Fibrosis via the TGF-?1/Smads Signal Transduction Pathway in IgA Nephropathy
    Authors: L Zhang, C Han, F Ye, Y He, Y Jin, T Wang, Y Wu, Y Jiang, F Zhang, X Jin
    Int J Mol Sci, 2017-02-12;18(2):.  2017-02-12
  30. MicroRNA?185 regulates transforming growth factor??1 and collagen?1 in hypertrophic scar fibroblasts
    Authors: K Xiao, X Luo, X Wang, Z Gao
    Mol Med Rep, 2017-02-08;0(0):.  2017-02-08
  31. LUBAC modulates LMP1 activation of NF?B and IRF7
    Authors: Ling Wang
    J. Virol, 2017-01-31;0(0):.  2017-01-31
  32. Butyrate attenuates lipolysis in adipocytes co-cultured with macrophages through non-prostaglandin E2-mediated and prostaglandin E2-mediated pathways
    Lipids Health Dis, 2016-12-09;15(1):213.  2016-12-09
  33. BHX Inhibits the Wnt Signaling Pathway by Suppressing ?-catenin Transcription in the Nucleus
    Sci Rep, 2016-12-02;6(0):38331.  2016-12-02
  34. Identification of Chemical Compounds That Inhibit Protein Synthesis in Pseudomonas aeruginosa.
    Authors: Palmer S, Hu Y, Keniry M, Bullard J
    SLAS Discov, 2016-11-21;22(6):775-782.  2016-11-21
  35. Discovery and Analysis of Natural-Product Compounds Inhibiting Protein Synthesis in Pseudomonas aeruginosa.
    Authors: Hu Y, Keniry M, Palmer S, Bullard J
    Antimicrob Agents Chemother, 2016-07-22;60(8):4820-9.  2016-07-22
  36. Inhibition of hyaluronic acid formation sensitizes chronic myelogenous leukemia to treatment with doxorubicin
    Authors: Olga N Uchakina
    Glycobiology, 2016-06-03;0(0):.  2016-06-03
  37. Identification of a Potent and Broad-Spectrum Hepatitis C Virus Fusion Inhibitory Peptide from the E2 Stem Domain
    Sci Rep, 2016-04-28;6(0):25224.  2016-04-28
  38. The Role of Angiogenesis in the Persistence of Chemoresistance in Epithelial Ovarian Cancer.
    Authors: Nusrat O, Belotte J, Fletcher N, Memaj I, Saed M, Diamond M, Saed G
    Reprod Sci, 2016-04-26;23(11):1484-1492.  2016-04-26
  39. ALDH1A3, the major aldehyde dehydrogenase isoform in human cholangiocarcinoma cells, affects prognosis and gemcitabine resistance in cholangiocarcinoma patients
    Authors: MH Chen, JJ Weng, CT Cheng, RC Wu, SC Huang, CE Wu, YH Chung, CY Liu, MH Chang, MH Chen, KC Chiang, TS Yeh, Y Su, CN Yeh
    Clin Cancer Res, 2016-04-13;0(0):.  2016-04-13
  40. Identification of a Small Molecule That Overcomes HdmX-Mediated Suppression of p53.
    Authors: Karan G, Wang H, Chakrabarti A, Karan S, Liu Z, Xia Z, Gundluru M, Moreton S, Saunthararajah Y, Jackson M, Agarwal M, Wald D
    Mol Cancer Ther, 2016-02-16;15(4):574-582.  2016-02-16
  41. Nicotine Reduces Survival via Augmentation of Paracrine HGF-MET Signaling in the Pancreatic Cancer Microenvironment.
    Authors: Delitto D, Zhang D, Han S, Black B, Knowlton A, Vlada A, Sarosi G, Behrns K, Thomas R, Lu X, Liu C, George T, Hughes S, Wallet S, Trevino J
    Clin Cancer Res, 2015-12-14;22(7):1787-99.  2015-12-14
  42. A Gene Expression Signature Associated with Overall Survival in Patients with Hepatocellular Carcinoma Suggests a New Treatment Strategy.
    Authors: Gillet J, Andersen J, Madigan J, Varma S, Bagni R, Powell K, Burgan W, Wu C, Calcagno A, Ambudkar S, Thorgeirsson S, Gottesman M
    Mol Pharmacol, 2015-12-14;89(2):263-72.  2015-12-14
  43. Sigma-2 Receptors Play a Role in Cellular Metabolism: Stimulation of Glycolytic Hallmarks by CM764 in Human SK-N-SH Neuroblastoma.
    Authors: Nicholson H, Mesangeau C, McCurdy C, Bowen W
    J Pharmacol Exp Ther, 2015-11-16;356(2):232-43.  2015-11-16
  44. Imidazolium salts as small-molecule urinary bladder exfoliants in a murine model.
    Authors: Wagers P, Tiemann K, Shelton K, Kofron W, Panzner M, Wooley K, Youngs W, Hunstad D
    Antimicrob Agents Chemother, 2015-06-29;59(9):5494-502.  2015-06-29
  45. Identification of Chemical Compounds That Inhibit the Function of Glutamyl-tRNA Synthetase from Pseudomonas aeruginosa.
    Authors: Hu Y, Guerrero E, Keniry M, Manrrique J, Bullard J
    J Biomol Screen, 2015-06-26;20(9):1160-70.  2015-06-26
  46. Characterization of CM572, a Selective Irreversible Partial Agonist of the Sigma-2 Receptor with Antitumor Activity.
    Authors: Nicholson H, Comeau A, Mesangeau C, McCurdy C, Bowen W
    J Pharmacol Exp Ther, 2015-06-01;354(2):203-12.  2015-06-01
  47. Sirt7 promotes gastric cancer growth and inhibits apoptosis by epigenetically inhibiting miR-34a.
    Authors: Zhang, Shun, Chen, Ping, Huang, Zuoan, Hu, Xiaorong, Chen, Mengting, Hu, Shanshan, Hu, Yixin, Cai, Ting
    Sci Rep, 2015-04-10;5(0):9787.  2015-04-10
  48. Identification of a negative regulatory role for spi-C in the murine B cell lineage.
    Authors: Li S, Solomon L, Fulkerson P, DeKoter R
    J Immunol, 2015-03-13;194(8):3798-807.  2015-03-13
  49. Nfkb1 activation by the E26 transformation-specific transcription factors PU.1 and Spi-B promotes Toll-like receptor-mediated splenic B cell proliferation.
    Authors: Li S, Abbas A, Solomon L, Groux G, DeKoter R
    Mol Cell Biol, 2015-03-02;35(9):1619-32.  2015-03-02
  50. Vaccine-induced tumor necrosis factor-producing T cells synergize with cisplatin to promote tumor cell death.
    Authors: van der Sluis T, van Duikeren S, Huppelschoten S, Jordanova E, Beyranvand Nejad E, Sloots A, Boon L, Smit V, Welters M, Ossendorp F, van de Water B, Arens R, van der Burg S, Melief C
    Clin Cancer Res, 2014-12-12;21(4):781-94.  2014-12-12
  51. Lenalidomide interferes with tumor-promoting properties of nurse-like cells in chronic lymphocytic leukemia.
    Authors: Fiorcari S, Martinelli S, Bulgarelli J, Audrito V, Zucchini P, Colaci E, Potenza L, Narni F, Luppi M, Deaglio S, Marasca R, Maffei R
    Haematologica, 2014-11-14;100(2):253-62.  2014-11-14
  52. A potential wound-healing-promoting peptide from salamander skin.
    Authors: Mu L, Tang J, Liu H, Shen C, Rong M, Zhang Z, Lai R
    FASEB J, 2014-05-27;28(9):3919-29.  2014-05-27
  53. Endothelin A receptor antagonism enhances inhibitory effects of anti-ganglioside GD2 monoclonal antibody on invasiveness and viability of human osteosarcoma cells.
    Authors: Liu B, Wu Y, Zhou Y, Peng D
    PLoS ONE, 2014-04-11;9(4):e93576.  2014-04-11
  54. Sex and genetic factors determine osteoblastic differentiation potential of murine bone marrow stromal cells.
    Authors: Zanotti S, Kalajzic I, Aguila H, Canalis E
    PLoS ONE, 2014-01-28;9(1):e86757.  2014-01-28
  55. Helicobacter pylori-driven modulation of NK cell expansion, intracellular cytokine expression and cytotoxic activity.
    Authors: Rudnicka K, Miszczyk E, Matusiak A, Walencka M, Moran A, Rudnicka W, Chmiela M
    Innate Immun, 2014-01-21;21(2):127-39.  2014-01-21
  56. Sirt2 suppresses glioma cell growth through targeting NF-kappaB-miR-21 axis.
    Authors: Li Y, Dai D, Lu Q, Fei M, Li M, Wu X
    Biochem Biophys Res Commun, 2013-10-22;441(3):661-7.  2013-10-22
  57. Role of endothelin B receptor in oligodendroglioma proliferation and survival: In vitro and in vivo evidence.
    Authors: Wan X, Zhang L, Jiang B
    Mol Med Rep, 2013-10-22;9(1):229-34.  2013-10-22
  58. Barrier-protective effects of activated protein C in human alveolar epithelial cells.
    Authors: Puig F, Fuster G, Adda M, Blanch L, Farre R, Navajas D, Artigas A
    PLoS ONE, 2013-02-22;8(2):e56965.  2013-02-22
  59. Regulation of bovine pyruvate carboxylase mRNA and promoter expression by thermal stress.
    Authors: White H, Koser S, Donkin S
    J Anim Sci, 2012-08-02;90(9):2979-87.  2012-08-02
  60. Central role of SREBP-2 in the pathogenesis of osteoarthritis.
    Authors: Kostopoulou F, Gkretsi V, Malizos KN, Iliopoulos D, Oikonomou P, Poultsides L, Tsezou A
    PLoS ONE, 2012-05-25;7(5):e35753.  2012-05-25
  61. Proinflammatory actions of visfatin/nicotinamide phosphoribosyltransferase (Nampt) involve regulation of insulin signaling pathway and Nampt enzymatic activity.
    Authors: Jacques C, Holzenberger M, Mladenovic Z
    J. Biol. Chem., 2012-03-07;287(18):15100-8.  2012-03-07
  62. Integrative genomics identified RFC3 as an amplified candidate oncogene in esophageal adenocarcinoma.
    Authors: Lockwood W, Thu K, Lin L, Pikor L, Chari R, Lam W, Beer D
    Clin Cancer Res, 2012-02-10;18(7):1936-46.  2012-02-10
  63. Homo sapiens systemic RNA interference-defective-1 transmembrane family member 1 (SIDT1) protein mediates contact-dependent small RNA transfer and microRNA-21-driven chemoresistance.
    Authors: Elhassan M, Christie J, Duxbury M
    J Biol Chem, 2011-12-15;287(8):5267-77.  2011-12-15
  64. Prothymosin-alpha interacts with mutant huntingtin and suppresses its cytotoxicity in cell culture.
    Authors: Dong G, Callegari E, Gloeckner C, Ueffing M, Wang H
    J Biol Chem, 2011-11-22;287(2):1279-89.  2011-11-22
  65. In vitro antimicrobial studies of silver carbene complexes: activity of free and nanoparticle carbene formulations against clinical isolates of pathogenic bacteria.
    Authors: Leid J, Ditto A, Knapp A, Shah P, Wright B, Blust R, Christensen L, Clemons C, Wilber J, Young G, Kang A, Panzner M, Cannon C, Yun Y, Youngs W, Seckinger N, Cope E
    J Antimicrob Chemother, 2011-10-03;67(1):138-48.  2011-10-03
  66. The major outer membrane protein of a periodontopathogen induces IFN-beta and IFN-stimulated genes in monocytes via lipid raft and TANK-binding kinase 1/IFN regulatory factor-3.
    Authors: Lee SH, Kim JS, Jun HK
    J. Immunol., 2009-05-01;182(9):5823-35.  2009-05-01
  67. Neonatal porcine Sertoli cells inhibit human natural antibody-mediated lysis.
    Authors: Dufour JM, Hamilton M, Rajotte RV, Korbutt GS
    Biol. Reprod., 2005-01-19;72(5):1224-31.  2005-01-19

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