Recombinant Human IGF-I/IGF-1 Protein, CF

Catalog # Availability Size / Price Qty
291-G1-200
291-G1-01M
Graph showing dose-dependent bioactivity of IGF-1 protein
3 Images
Product Details
Citations (138)
FAQs
Supplemental Products
Reviews (5)

Recombinant Human IGF-I/IGF-1 Protein, CF Summary

Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Level
<0.10 EU per 1 μg of the protein by the LAL method.
Activity
Measured in a serum-free cell proliferation assay using MCF‑7 human breast cancer cells. Karey, K.P. et al. (1988) Cancer Research 48:4083. The ED50 for this effect is 0.3-1.5 ng/mL.
The specific activity of recombinant human IGF-I/IGF-1 is approximately 2.5 IU/μg, which is calibrated against recombinant human IGF-I/IGF-1 WHO International Standard (NIBSC code: 91/554).
Source
E. coli-derived human IGF-I/IGF-1 protein
Gly49-Ala118
Accession #
N-terminal Sequence
Analysis
Gly49
Predicted Molecular Mass
7.6 kDa
SDS-PAGE
7 kDa, reducing conditions

Product Datasheets

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

291-G1

Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution Reconstitute at 200 μg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Data Images

Bioactivity Bioactivity of Human IGF-1 Protein View Larger

Recombinant Human IGF-I / IGF-1 (Catalog # 291-G1) stimulates proliferation in the MCF-7 human breast cancer cell line. The ED50for this effect is 0.3‑1.5 ng/mL.

SDS-PAGE SDS-PAGE of Human IGF-1 Protein View Larger

1 μg/lane of Recombinant Human IGF-I / IGF-1 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 7 kDa.

Mass Spectrometry Mass Spectrometry of Human IGF-1 Protein View Larger

MALDI-TOF analysis of Recombinant Human IGF-I / IGF-1. The major peak corresponds to the calculated molecular mass, 7650 Da. The minor peak at 7873 is a matrix-associated artifact of the MALDI-TOF.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: IGF-I/IGF-1

Insulin-like growth factor I (IGF-I or IGF-1), also known as somatomedin C, is the dominant effector of growth hormone and is structurally homologous to proinsulin. Human IGF-1 is synthesized as two precursor isoforms with N- and alternate C‑terminal propeptides (1). These isoforms are differentially expressed by various tissues (1). The 7.6 kDa mature IGF-1 protein is identical between isoforms and is generated by proteolytic removal of the N- and C‑terminal regions. Mature human IGF-1 shares 94% and 96% aa sequence identity with mouse and rat IGF-1, respectively (2), and exhibits cross-species activity. It shares 64% aa sequence identity with mature human IGF-II/IGF-2. Circulating IGF-I is produced by hepatocytes, while local IGF-I is produced by many other tissues in which it has paracrine effects (1). IGF-I induces the proliferation, migration, and differentiation of a wide variety of cell types during development and postnatally (3). IGF-I regulates glucose and fatty acid metabolism, steroid hormone activity, and cartilage and bone metabolism (4‑7). It plays an important role in muscle regeneration and tumor progression (1, 8). IGF-I/IGF-1 binds IGF-I R, IGF-II R, and the insulin receptor, although its effects are mediated primarily by IGF-I R (9). The IGF-I protein associates with IGF binding proteins thereby increasing its plasma half‑life and modulating its interactions with receptors (10).

References
  1. Philippou, A. et al. (2007) In Vivo 21:45.
  2. Sandberg-Nordqvist, A.C. et al. (1992) Brain Res. Mol. Brain Res. 12:275.
  3. Guvakova, M.A. (2007) Int. J. Biochem. Cell Biol. 39:890.
  4. Clemmons, D.R. (2006) Curr. Opin. Pharmacol. 6:620.
  5. Bluher, S. et al. (2005) Best Pract. Res. Clin. Endocrinol. Metab. 19:577.
  6. Garcia-Segura, L.M. et al. (2006) Neuroendocrinology 84:275.
  7. Malemud, C.J. (2007) Clin. Chim. Acta 375:10.
  8. Samani, A.A. et al. (2007) Endocrine Rev. 28:20.
  9. LeRoith, D. and S. Yakar (2007) Nat. Clin. Pract. Endocrinol. Metab. 3:302.
  10. Denley, A. et al. (2005) Cytokine Growth Factor Rev. 16:421.
Long Name
Insulin-like Growth Factor I/Insulin-like Growth Factor 1
Entrez Gene IDs
3479 (Human); 16000 (Mouse); 24482 (Rat)
Alternate Names
IBP1; IGF1; IGF-1; IGF1A; IGFI; IGF-I; IGF-IA; IGF-IB; insulin-like growth factor 1 (somatomedin C); insulin-like growth factor 1; insulin-like growth factor I; insulin-like growth factor IA; insulin-like growth factor IB; Mechano growth factor; MGF; Somatomedin A; Somatomedin C; somatomedin-C

Citations for Recombinant Human IGF-I/IGF-1 Protein, CF

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

138 Citations: Showing 1 - 10
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  1. Intracellular Insulin-like growth factor binding protein 2 (IGFBP2) contributes to the senescence of keratinocytes in psoriasis by stabilizing cytoplasmic p21
    Authors: L Mercurio, D Lulli, F Mascia, E Dellambra, C Scarponi, M Morelli, C Valente, ML Carbone, S Pallotta, G Girolomoni, C Albanesi, S Pastore, S Madonna
    Aging (Albany NY), 2020;12(8):6823-6851.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  2. Establishment of SLC15A1/PEPT1-Knockout Human-Induced Pluripotent Stem Cell Line for Intestinal Drug Absorption Studies
    Authors: K Kawai, R Negoro, M Ichikawa, T Yamashita, S Deguchi, K Harada, K Hirata, K Takayama, H Mizuguchi
    Mol Ther Methods Clin Dev, 2020;17(0):49-57.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  3. Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies
    Authors: B Mair, J Tomic, SN Masud, P Tonge, A Weiss, M Usaj, AHY Tong, JJ Kwan, KR Brown, E Titus, M Atkins, KSK Chan, L Munsie, A Habsid, H Han, M Kennedy, B Cohen, G Keller, J Moffat
    Cell Rep, 2019;27(2):599-615.e12.
    Species: Human
    Sample Types: cell culture
    Applications: Differentiation
  4. Cellular characterization of human epicardial adipose tissue: highly expressed PAPP-A regulates insulin-like growth factor I signaling in human cardiomyocytes
    Authors: CA Conover, LK Bale, RL Frye, HV Schaff
    Physiol Rep, 2019;7(4):e14006.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  5. CAMKII as a therapeutic target for growth factor-induced retinal and choroidal neovascularisation
    Authors: S Ashraf, S Bell, C O'Leary, P Canning, I Micu, JA Fernandez, M O'Hare, P Barabas, H McCauley, DP Brazil, AW Stitt, JG McGeown, TM Curtis
    JCI Insight, 2019;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  6. Theaflavins prevent cartilage degeneration via AKT/FOXO3 signaling in�vitro
    Authors: J Li, J Zheng
    Mol Med Rep, 2019;19(2):821-830.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  7. Selective estrogen receptor modulators enhance CNS remyelination independent of estrogen receptors
    Authors: KA Rankin, F Mei, K Kim, YA Shen, SR Mayoral, C Desponts, DS Lorrain, AJ Green, SE Baranzini, JR Chan, R Bove
    J. Neurosci., 2019;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  8. Establishment of an erythroid progenitor cell line capable of enucleation achieved with an inducible c-Myc vector
    Authors: S Mayers, PD Moço, T Maqbool, PN Silva, DM Kilkenny, J Audet
    BMC Biotechnol., 2019;19(1):21.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  9. Ginsenoside Rg5 induces apoptosis in human esophageal cancer cells through the phosphoinositide?3 kinase/protein kinase B signaling pathway
    Authors: D Zhang, A Wang, J Feng, Q Zhang, L Liu, H Ren
    Mol Med Rep, 2019;19(5):4019-4026.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  10. A Potential Antitumor Effect of Dendritic Cells Fused with Cancer Stem Cells in Hepatocellular Carcinoma
    Authors: YB Pang, J He, BY Cui, S Xu, XL Li, MY Wu, R Liang, Y Feng, X Guo, XH Zhang, XL Luo
    Stem Cells Int, 2019;2019(0):5680327.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  11. SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis
    Authors: G Wang, J Long, Y Gao, W Zhang, F Han, C Xu, L Sun, SC Yang, J Lan, Z Hou, Z Cai, G Jin, CC Hsu, YH Wang, J Hu, TY Chen, H Li, MG Lee, HK Lin
    Nat. Cell Biol., 2019;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  12. Effects of N-carbamylglutamate and arginine on steroidogenesis and proliferation of pig granulosa cells in vitro
    Authors: T Feng, AA DeVore, MC Perego, BC Morrell, LJ Spicer
    Anim. Reprod. Sci., 2019;209(0):106138.
    Species: Porcine
    Sample Types: Whole Cells
    Applications: Bioassay
  13. IGF-1R Inhibition Suppresses Cell Proliferation and Increases Radiosensitivity in Nasopharyngeal Carcinoma Cells
    Authors: Z Wang, G Liu, J Mao, M Xie, M Zhao, X Guo, S Liang, H Li, X Li, R Wang
    Mediators Inflamm., 2019;2019(0):5497467.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  14. Re-Differentiation Capacity of Human Chondrocytes in Vitro Following Electrical Stimulation with Capacitively Coupled Fields
    Authors: S Krueger, S Achilles, J Zimmermann, T Tischer, R Bader, A Jonitz-Hei
    J Clin Med, 2019;8(11):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  15. Oligodendrocyte Intrinsic miR-27a Controls Myelination and Remyelination
    Authors: A Tripathi, C Volsko, JP Garcia, E Agirre, KC Allan, PJ Tesar, BD Trapp, G Castelo-Br, FJ Sim, R Dutta
    Cell Rep, 2019;29(4):904-919.e9.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  16. V2a interneuron differentiation from mouse and human pluripotent stem cells
    Authors: JC Butts, N Iyer, N White, R Thompson, S Sakiyama-E, TC McDevitt
    Nat Protoc, 2019;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  17. Reprogramming of Fibroblasts to Oligodendrocyte Progenitor-like Cells Using CRISPR/Cas9-Based Synthetic Transcription Factors
    Authors: M Matjusaiti, LJ Wagstaff, A Martella, B Baranowski, C Blin, S Gogolok, A Williams, SM Pollard
    Stem Cell Reports, 2019;13(6):1053-1067.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  18. An inactivating mutation in the histone deacetylase SIRT6 causes human perinatal lethality
    Authors: CM Ferrer, M Alders, AV Postma, S Park, MA Klein, M Cetinbas, E Pajkrt, A Glas, S van Koning, VM Christoffe, MMAM Mannens, L Knegt, JP Etchegaray, RI Sadreyev, JM Denu, G Mostoslavs, MC van Maarle, R Mostoslavs
    Genes Dev., 2018;32(5):373-388.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  19. Human ESC-Derived Chimeric Mouse Models of Huntington's Disease Reveal Cell-Intrinsic Defects in Glial Progenitor Cell Differentiation
    Authors: M Osipovitch, A Asenjo Mar, JN Mariani, A Cornwell, S Dhaliwal, L Zou, D Chandler-M, S Wang, X Li, SJ Benraiss, R Agate, A Lampp, A Benraiss, MS Windrem, SA Goldman
    Cell Stem Cell, 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  20. Celastrol Attenuates the Invasion and Migration and Augments the Anticancer Effects of Bortezomib in a Xenograft Mouse Model of Multiple Myeloma
    Authors: MK Shanmugam, KS Ahn, JH Lee, R Kannaiyan, N Mustafa, KA Manu, KS Siveen, G Sethi, WJ Chng, AP Kumar
    Front Pharmacol, 2018;9(0):365.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  21. The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington's disease patients
    Authors: S Koyuncu, I Saez, HJ Lee, R Gutierrez-, W Pokrzywa, A Fatima, T Hoppe, D Vilchez
    Nat Commun, 2018;9(1):2886.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  22. Development of a Graphene Oxide-Incorporated Polydimethylsiloxane Membrane with Hexagonal Micropillars
    Authors: YY Lin, Y Chien, JH Chuang, CC Chang, YP Yang, YH Lai, WL Lo, KH Chien, TI Huo, CY Wang
    Int J Mol Sci, 2018;19(9):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  23. Insulin-Like Growth Factor-I as an Effector Element of the Cytokine IL-4 in the Development of a Leishmania major Infection
    Authors: LC Reis, EM Ramos-Sanc, F Petitto-As, AH Nerland, M Hernandez-, F Selheim, LM Floeter-Wi, H Goto
    Mediators Inflamm., 2018;2018(0):9787128.
    Species: Mouse
    Sample Types: In Vivo
  24. Generation and characterization of two human induced pluripotent stem cell (hiPSC) lines homozygous for the Apolipoprotein e4 (APOE4) risk variant-Alzheimer's disease (ASUi005-A) and healthy non-demented control (ASUi006-A)
    Authors: N Brookhouse, P Zhang, R Caselli, JJ Kim, DA Brafman
    Stem Cell Res, 2018;32(0):145-149.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  25. Functional Assessment of Patient-Derived Retinal Pigment Epithelial Cells Edited by CRISPR/Cas9
    Authors: LP Foltz, SE Howden, JA Thomson, DO Clegg
    Int J Mol Sci, 2018;19(12):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  26. TBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets
    Authors: B Decaesteke, G Denecker, C Van Neste, EM Dolman, W Van Loocke, M Gartlgrube, C Nunes, F De Vloed, P Depuydt, K Verboom, D Rombaut, S Loontiens, J De Wyn, WM Kholosy, B Koopmans, AHW Essing, C Herrmann, D Dreidax, K Durinck, D Deforce, F van Nieuwe, A Henssen, R Versteeg, V Boeva, G Schleierma, J van Nes, P Mestdagh, S Vanhauwaer, JH Schulte, F Westermann, JJ Molenaar, K De Preter, F Speleman
    Nat Commun, 2018;9(1):4866.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  27. Involvement of the capsular GalXM-induced IL-17 cytokine in the control of Cryptococcus neoformans infection
    Authors: IF LaRocque-d, JDB Rocha, MP Nunes, PAV Oliveira, DO Nascimento, L Freire-de-, CM Takiya, A Morrot, D Decote-Ric, JO Previato, GA DosReis, L Mendonça-P, CG Freire-de-
    Sci Rep, 2018;8(1):16378.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  28. VGF nerve growth factor inducible is involved in retinal ganglion cells death induced by optic nerve crush
    Authors: H Takeuchi, S Inagaki, W Morozumi, Y Nakano, Y Inoue, Y Kuse, T Mizoguchi, S Nakamura, M Funato, H Kaneko, H Hara, M Shimazawa
    Sci Rep, 2018;8(1):16443.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  29. Efficient Generation of Small Intestinal Epithelial-like Cells from Human iPSCs for Drug Absorption and Metabolism Studies
    Authors: R Negoro, K Takayama, K Kawai, K Harada, F Sakurai, K Hirata, H Mizuguchi
    Stem Cell Reports, 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  30. Modulation of hyaluronan polymer size regulates proliferation of perimysial fibroblasts in thyroid eye disease
    Authors: R Ma, Q Li, Z Wang, Y Yuan, L Gan, J Qian
    Biochem. Biophys. Res. Commun., 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  31. Urolithin A, a novel natural compound to target PI3K/AKT/mTOR pathway in pancreatic cancer
    Authors: TM Totiger, S Srinivasan, VR Jala, P Lamichhane, AR Dosch, AA Gaidarski, C Joshi, S Rangappa, J Castellano, PK Vemula, X Chen, D Kwon, N Kashikar, M VanSaun, NB Merchant, NS Nagathihal
    Mol. Cancer Ther., 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  32. Aberrant expression of NKL homeobox gene HLX in Hodgkin lymphoma
    Authors: S Nagel, C Pommerenke, C Meyer, M Kaufmann, RAF MacLeod, HG Drexler
    Oncotarget, 2018;9(18):14338-14353.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  33. Fast neurogenesis from carotid body quiescent neuroblasts accelerates adaptation to hypoxia
    Authors: V Sobrino, P González-R, V Annese, J López-Barn, R Pardal
    EMBO Rep., 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  34. Chromosomal instability during neurogenesis in Huntington's disease
    Authors: A Ruzo, GF Croft, JJ Metzger, S Galgoczi, LJ Gerber, C Pellegrini, H Wang, M Fenner, S Tse, A Marks, C Nchako, AH Brivanlou
    Development, 2018;145(2):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Differentiation
  35. Short Term Development and Fate of MGE-Like Neural Progenitor Cells in Jaundiced and Non-Jaundiced Rat Brain
    Authors: FC Yang, J Draper, PG Smith, JL Vivian, SM Shapiro, JA Stanford
    Cell Transplant, 2018;0(0):9636897187663.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  36. In Vitro Regeneration of Patient-specific Ear-shaped Cartilage and Its First Clinical Application for Auricular Reconstruction
    Authors: G Zhou, H Jiang, Z Yin, Y Liu, Q Zhang, C Zhang, B Pan, J Zhou, X Zhou, H Sun, D Li, A He, Z Zhang, W Zhang, W Liu, Y Cao
    EBioMedicine, 2018;28(0):287-302.
    Species: Human
    Sample Types: Complex Sample Type
    Applications: Bioassay
  37. Experimental Study of the Biological Properties of Human Embryonic Stem Cell-Derived Retinal Progenitor Cells
    Authors: J Shao, PY Zhou, GH Peng
    Sci Rep, 2017;7(0):42363.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  38. Establishment of an induced pluripotent stem cell (iPSC) line from a 9-year old male with autism spectrum disorder (ASD)
    Authors: E Varga, C Nemes, I Bock, Z Táncos, S Berzsenyi, G Lévay, V Román, J Kobolák, A Dinnyés
    Stem Cell Res, 2017;21(0):19-22.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  39. Modeling the Mutational and Phenotypic Landscapes of Pelizaeus-Merzbacher Disease with Human iPSC-Derived Oligodendrocytes
    Authors: ZS Nevin, DC Factor, RT Karl, P Douvaras, J Laukka, MS Windrem, SA Goldman, V Fossati, GM Hobson, PJ Tesar
    Am. J. Hum. Genet., 2017;100(4):617-634.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  40. Insulin-Like Growth Factor-1 Increases the Expression of Inflammatory Biomarkers and Sebum Production in Cultured Sebocytes
    Authors: H Kim, SY Moon, MY Sohn, WJ Lee
    Ann Dermatol, 2017;29(1):20-25.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  41. Severe pre-eclampsia is associated with alterations in cytotrophoblasts of the smooth chorion
    Authors: T Garrido-Go, K Ona, M Kapidzic, M Gormley, C Simón, O Genbacev, SJ Fisher
    Development, 2017;144(5):767-777.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  42. Inhibition of Proliferation and Epithelial Mesenchymal Transition in Retinal Pigment Epithelial Cells by Heavy Chain-Hyaluronan/Pentraxin 3
    Authors: H He, AE Kuriyan, CW Su, M Mahabole, Y Zhang, YT Zhu, HW Flynn, JM Parel, SC Tseng
    Sci Rep, 2017;7(0):43736.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  43. Atypical PKC and Notch Inhibition Differentially Modulate Cortical Interneuron Subclass Fate from Embryonic Stem Cells
    Authors: DJ Tischfield, J Kim, SA Anderson
    Stem Cell Reports, 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  44. IL-37 induces autophagy in hepatocellular carcinoma cells by inhibiting the PI3K/AKT/mTOR pathway
    Authors: TT Li, D Zhu, T Mou, Z Guo, JL Pu, QS Chen, XF Wei, ZJ Wu
    Mol. Immunol., 2017;87(0):132-140.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  45. Retinoic Acid-Signaling Regulates the Proliferative and Neurogenic Capacity of M�ller Glia-Derived Progenitor Cells in the Avian Retina
    Authors: L Todd, L Suarez, C Quinn, AJ Fischer
    Stem Cells, 2017;0(0):.
    Species: Chicken
    Sample Types: In Vivo
    Applications: In Vivo
  46. Soluble klotho binds monosialoganglioside to regulate membrane microdomains and growth factor signaling
    Authors: G Dalton, SW An, SI Al-Juboori, N Nischan, J Yoon, E Dobrinskik, DW Hilgemann, J Xie, K Luby-Phelp, JJ Kohler, L Birnbaumer, CL Huang
    Proc. Natl. Acad. Sci. U.S.A, 2017;114(4):752-757.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  47. Differential involvement of the microtubule cytoskeleton in Insulin Receptor Substrate-1 (IRS-1) and IRS-2 signaling to AKT determines response to microtubule disruption in breast carcinoma cells
    Authors: J Mercado-Ma, JL Clark, AJ Piper, J Janusis, LM Shaw
    J. Biol. Chem, 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  48. Notch transactivates Rheb to maintain the multipotency of TSC-null cells.
    Authors: Jun-Hung Cho, Bhaumik Patel, Santosh Bonala, Sasikanth Manne, Yan Zhou, Surya K Vadrevu, Jalpa Patel, Marco Peronaci, Shanawaz Ghouse, Elizabeth P Henske, Fabrice Roegiers, Krinio Giannikou, David J Kwiatkows, Hossein Mansouri, Maciej M Markiewsk, Brandon White, Magdalena Karbownic
    Nature Communications, 2017;0(0):2041-1723.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  49. IGF-IR cooperates with ER? to inhibit breast cancer cell aggressiveness by regulating the expression and localisation of ECM molecules
    Authors: NA Afratis, P Bouris, SS Skandalis, HA Multhaupt, JR Couchman, AD Theocharis, NK Karamanos
    Sci Rep, 2017;7(0):40138.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  50. Human iPSC-Derived Neural Progenitors Are an Effective Drug Discovery Model for Neurological mtDNA Disorders
    Authors: C Lorenz, P Lesimple, R Bukowiecki, A Zink, G Inak, B Mlody, M Singh, M Semtner, N Mah, K Aur‚, M Leong, O Zabiegalov, EM Lyras, V Pfiffer, B Fauler, J Eichhorst, B Wiesner, N Huebner, J Priller, T Mielke, D Meierhofer, Z Izsv k, JC Meier, F Bouillaud, J Adjaye, M Schuelke, EE Wanker, A LombŠs, A Prigione
    Cell Stem Cell, 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  51. Expression patterns of FSHD-causing DUX4 and myogenic transcription factors PAX3 and PAX7 are spatially distinct in differentiating human stem cell cultures
    Authors: P Haynes, K Kernan, SL Zhou, DG Miller
    Skelet Muscle, 2017;7(1):13.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  52. Transplantation of Human Embryonic Stem Cell-Derived Retinal Cells into the Subretinal Space of a Non-Human Primate
    Authors: JR Chao, DA Lamba, TR Klesert, A Torre, A Hoshino, RJ Taylor, A Jayabalu, AL Engel, TH Khuu, RK Wang, M Neitz, J Neitz, TA Reh
    Transl Vis Sci Technol, 2017;6(3):4.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  53. Abnormal IGF-Binding Protein Profile in the Bone Marrow of Multiple Myeloma Patients
    Authors: L Bieghs, M Brohus, IB Kristensen, N Abildgaard, M Bøgsted, HE Johnsen, CA Conover, E De Bruyne, K Vanderkerk, MT Overgaard, M Nyegaard
    PLoS ONE, 2016;11(4):e0154256.
    Species: Human
    Sample Types: Plasma
    Applications: Bioassay
  54. Structural and functional investigations of the effector protein LpiR1 from Legionella pneumophila
    J Biol Chem, 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  55. 3D patterned stem cell differentiation using thermo-responsive methylcellulose hydrogel molds
    Sci Rep, 2016;6(0):29408.
    Species: Human
    Sample Types:
  56. TGF? signaling confers sorafenib resistance via induction of multiple RTKs in hepatocellular carcinoma cells
    Authors: Tong Wu
    Mol. Carcinog., 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  57. Metabolites involved in glycolysis and amino acid metabolism are altered in short children born small for gestational age
    Authors: Peter E Clayton
    Pediatr. Res., 2016;80(2):299-305.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  58. Application of single-cell RNA sequencing in optimizing a combinatorial therapeutic strategy in metastatic renal cell carcinoma
    Genome Biol, 2016;17(1):80.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  59. IGF1R as a Key Target in High Risk, Metastatic Medulloblastoma
    Authors: Matthew N Svalina
    Sci Rep, 2016;6(0):27012.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  60. G protein-coupled receptor 34 in ovarian granulosa cells of cattle: changes during follicular development and potential functional implications
    Authors: L J Spicer
    Domest. Anim. Endocrinol, 2016;59(0):90-99.
    Species: Bovine
    Sample Types: Whole Cells
    Applications: Bioassay
  61. Fibroblast growth factor 9 (FGF9) regulation of cyclin D1 and cyclin-dependent kinase-4 in ovarian granulosa and theca cells of cattle
    Authors: L J Spicer
    Mol. Cell. Endocrinol., 2016;0(0):.
    Species: Bovine
    Sample Types: Whole Cells
    Applications: Bioassay
  62. Evidence for direct effects of glyphosate on ovarian function: glyphosate influences steroidogenesis and proliferation of bovine granulosa but not theca cells in vitro
    Authors: Maria Chiara Perego
    J Appl Toxicol, 2016;0(0):.
    Species: Bovine
    Sample Types: Whole Cells
    Applications: Bioassay
  63. A Collagen Cardiac Patch Incorporating Alginate Microparticles Permits the Controlled Release of HGF and IGF-1 to Enhance Cardiac Stem Cell Migration and Proliferation
    Authors: Hugh S O'Neill
    J Tissue Eng Regen Med, 2016;0(0):.
    Applications: Scaffold Fabrication
  64. Polyurethane scaffolds seeded with CD34(+) cells maintain early stem cells whilst also facilitating prolonged egress of haematopoietic progenitors
    Sci Rep, 2016;6(0):32149.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  65. Tumor-Free Transplantation of Patient-Derived Induced Pluripotent Stem Cell Progeny for Customized Islet Regeneration
    Authors: Yasuhiro Ikeda
    Stem Cells Transl Med, 2016;5(5):694-702.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  66. Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity
    Authors: Ivan Carcamo-Or
    Cell Stem Cell, 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  67. The tobacco-specific carcinogen-operated calcium channel promotes lung tumorigenesis via IGF2 exocytosis in lung epithelial cells
    Nat Commun, 2016;7(0):12961.
    Species: Human
    Sample Types:
    Applications: Neutralization
  68. Tumor-Free Transplantation of Patient-Derived Induced Pluripotent Stem Cell Progeny for Customized Islet Regeneration
    Stem Cells Transl Med, 2016;5(5):694-702.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  69. Vascular niche promotes hematopoietic multipotent progenitor formation from pluripotent stem cells.
    Authors: Gori J, Butler J, Chan Y, Chandrasekaran D, Poulos M, Ginsberg M, Nolan D, Elemento O, Wood B, Adair J, Rafii S, Kiem H
    J Clin Invest, 2015;125(3):1243-54.
    Species: Primate - Macaca nemestrina (Southern Pig-tailed Macaque)
    Sample Types: Whole Cells
    Applications: Bioassay
  70. Specific activation of insulin-like growth factor-1 receptor by ginsenoside Rg5promotes angiogenesis and vasorelaxation.
    Authors: Cho Y, Hur S, Kim J, Kim J, Lee D, Choe J, Won M, Ha K, Jeoung D, Han S, Ryoo S, Lee H, Min J, Kwon Y, Kim D, Kim Y
    J Biol Chem, 2015;290(1):467-77.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  71. GlcUAbeta1-3Galbeta1-3Galbeta1-4Xyl(2-O-phosphate) is the preferred substrate for chondroitin N-acetylgalactosaminyltransferase-1.
    Authors: Izumikawa T, Sato B, Mikami T, Tamura J, Igarashi M, Kitagawa H
    J Biol Chem, 2015;290(9):5438-48.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  72. EphrinB2 controls vessel pruning through STAT1-JNK3 signalling.
    Authors: Salvucci O, Ohnuki H, Maric D, Hou X, Li X, Yoon S, Segarra M, Eberhart C, Acker-Palmer A, Tosato G
    Nat Commun, 2015;6(0):6576.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  73. Insulin like growth factor binding protein 7 (IGFBP7) expression is linked to poor prognosis but may protect from bone disease in multiple myeloma.
    Authors: Bolomsky A, Hose D, Schreder M, Seckinger A, Lipp S, Klein B, Heintel D, Ludwig H, Zojer N
    J Hematol Oncol, 2015;8(1):10.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  74. Insulin-like growth factor-I induces epithelial to mesenchymal transition via GSK-3beta and ZEB2 in the BGC-823 gastric cancer cell line.
    Authors: Li H, Xu L, Zhao L, Ma Y, Zhu Z, Liu Y, Qu X
    Oncol Lett, 2015;9(1):143-148.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  75. Patient-derived xenografts from non-small cell lung cancer brain metastases are valuable translational platforms for the development of personalized targeted therapy.
    Authors: Lee H, Lee J, Lee S, Cho H, Song H, Jeong D, Seo Y, Shin S, Joung J, Kwon Y, Choi Y, Park W, Lee H, Seol H, Shim Y, Joo K, Nam D
    Clin Cancer Res, 2015;21(5):1172-82.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  76. Functional EpoR pathway utilization is not detected in primary tumor cells isolated from human breast, non-small cell lung, colorectal, and ovarian tumor tissues.
    Authors: Patterson, Scott D, Rossi, John M, Paweletz, Katherin, Fitzpatrick, V Dan, Begley, C Glenn, Busse, Leigh, Elliott, Steve, McCaffery, Ian
    PLoS ONE, 2015;10(3):e0122149.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  77. IGFBP-4 and -5 are expressed in first-trimester villi and differentially regulate the migration of HTR-8/SVneo cells.
    Authors: Crosley, Erin J, Dunk, Caroline, Beristain, Alexande, Christians, Julian K
    Reprod Biol Endocrinol, 2015;12(0):123.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  78. Selective and potent Akt inhibition triggers anti-myeloma activities and enhances fatal endoplasmic reticulum stress induced by proteasome inhibition.
    Authors: Mimura N, Hideshima T, Shimomura T, Suzuki R, Ohguchi H, Rizq O, Kikuchi S, Yoshida Y, Cottini F, Jakubikova J, Cirstea D, Gorgun G, Minami J, Tai Y, Richardson P, Utsugi T, Iwama A, Anderson K
    Cancer Res, 2014;74(16):4458-69.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  79. Circumvention of Mcl-1-dependent drug resistance by simultaneous Chk1 and MEK1/2 inhibition in human multiple myeloma cells.
    Authors: Pei X, Dai Y, Felthousen J, Chen S, Takabatake Y, Zhou L, Youssefian L, Sanderson M, Bodie W, Kramer L, Orlowski R, Grant S
    PLoS ONE, 2014;9(3):e89064.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  80. Insulin-like growth factor 1 receptor is a prognostic factor in classical Hodgkin lymphoma.
    Authors: Liang Z, Diepstra A, Xu C, van Imhoff G, Plattel W, Van Den Berg A, Visser L
    PLoS ONE, 2014;9(1):e87474.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  81. The combined hyperlipidemia caused by impaired Wnt-LRP6 signaling is reversed by Wnt3a rescue.
    Authors: Go G, Srivastava R, Hernandez-Ono A, Gang G, Smith S, Booth C, Ginsberg H, Mani A
    Cell Metab, 2014;19(2):209-20.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  82. Minimally invasive approach to the repair of injured skeletal muscle with a shape-memory scaffold.
    Authors: Wang, Lin, Cao, Lan, Shansky, Janet, Wang, Zheng, Mooney, David, Vandenburgh, Herman
    Mol Ther, 2014;22(8):1441-9.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  83. Restoring Akt1 activity in outgrowth endothelial cells from South Asian men rescues vascular reparative potential.
    Authors: Cubbon R, Yuldasheva N, Viswambharan H, Mercer B, Baliga V, Stephen S, Askham J, Sukumar P, Skromna A, Mughal R, Walker A, Bruns A, Bailey M, Galloway S, Imrie H, Gage M, Rakobowchuk M, Li J, Porter K, Ponnambalam S, Wheatcroft S, Beech D, Kearney M
    Stem Cells, 2014;32(10):2714-23.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  84. Involvement of ER stress in dysmyelination of Pelizaeus-Merzbacher Disease with PLP1 missense mutations shown by iPSC-derived oligodendrocytes.
    Authors: Numasawa-Kuroiwa Y, Okada Y, Shibata S, Kishi N, Akamatsu W, Shoji M, Nakanishi A, Oyama M, Osaka H, Inoue K, Takahashi K, Yamanaka S, Kosaki K, Takahashi T, Okano H
    Stem Cell Reports, 2014;2(5):648-61.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  85. Epigallocatechin-3-gallate inhibits cell growth, induces apoptosis and causes S phase arrest in hepatocellular carcinoma by suppressing the AKT pathway.
    Authors: Shen X, Zhang Y, Feng Y, Zhang L, Li J, Xie Y, Luo X
    Int J Oncol, 2014;44(3):791-6.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  86. Co-targeting the IGF system and HIF-1 inhibits migration and invasion by (triple-negative) breast cancer cells.
    Authors: Mancini M, Gariboldi M, Taiana E, Bonzi M, Craparotta I, Pagin M, Monti E
    Br J Cancer, 2014;110(12):2865-73.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  87. CEP290 gene transfer rescues Leber congenital amaurosis cellular phenotype.
    Authors: Burnight E, Wiley L, Drack A, Braun T, Anfinson K, Kaalberg E, Halder J, Affatigato L, Mullins R, Stone E, Tucker B
    Gene Ther, 2014;21(7):662-72.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  88. Human cytomegalovirus infection of human embryonic stem cell-derived primitive neural stem cells is restricted at several steps but leads to the persistence of viral DNA.
    Authors: Belzile, Jean-Phi, Stark, Thomas J, Yeo, Gene W, Spector, Deborah
    J Virol, 2014;88(8):4021-39.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  89. Phosphoinositide protein kinase PDPK1 is a crucial cell signaling mediator in multiple myeloma.
    Authors: Chinen Y, Kuroda J, Shimura Y, Nagoshi H, Kiyota M, Yamamoto-Sugitani M, Mizutani S, Sakamoto N, Ri M, Kawata E, Kobayashi T, Matsumoto Y, Horiike S, Iida S, Taniwaki M
    Cancer Res, 2014;74(24):7418-29.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  90. MicroRNA-133a suppresses multiple oncogenic membrane receptors and cell invasion in non-small cell lung carcinoma.
    Authors: Wang, Lu-Kai, Hsiao, Tzu-Hung, Hong, Tse-Ming, Chen, Hsuan-Yu, Kao, Shih-Han, Wang, Wen-Lung, Yu, Sung-Lia, Lin, Ching-We, Yang, Pan-Chyr
    PLoS ONE, 2014;9(5):e96765.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  91. Ubiquitin ligase Cbl-b represses IGF-I-induced epithelial mesenchymal transition via ZEB2 and microRNA-200c regulation in gastric cancer cells.
    Authors: Li H, Xu L, Li C, Zhao L, Ma Y, Zheng H, Li Z, Zhang Y, Wang R, Liu Y, Qu X
    Mol Cancer, 2014;13(0):136.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  92. Human IGF1 regulates midgut oxidative stress and epithelial homeostasis to balance lifespan and Plasmodium falciparum resistance in Anopheles stephensi.
    Authors: Drexler A, Pietri J, Pakpour N, Hauck E, Wang B, Glennon E, Georgis M, Riehle M, Luckhart S
    PLoS Pathog, 2014;10(6):e1004231.
    Species: Insect
    Sample Types: In Vivo
    Applications: In Vivo
  93. The adherens junction protein afadin is an AKT substrate that regulates breast cancer cell migration.
    Authors: Elloul, Sivan, Kedrin, Dmitriy, Knoblauch, Nicholas, Beck, Andrew H, Toker, Alex
    Mol Cancer Res, 2014;12(3):464-76.
  94. Expansion and conversion of human pancreatic ductal cells into insulin-secreting endocrine cells.
    Authors: Lee J, Sugiyama T, Liu Y, Wang J, Gu X, Lei J, Markmann J, Miyazaki S, Miyazaki J, Szot G, Bottino R, Kim S
    Elife, 2013;2(0):e00940.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  95. Intrapatient variations in type 1 diabetes-specific iPS cell differentiation into insulin-producing cells.
    Authors: Thatava T, Kudva Y, Edukulla R, Squillace K, De Lamo J, Khan Y, Sakuma T, Ohmine S, Terzic A, Ikeda Y
    Mol Ther, 2013;21(1):228-39.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  96. Insulin signaling via Akt2 switches plakophilin 1 function from stabilizing cell adhesion to promoting cell proliferation.
    Authors: Wolf A, Rietscher K, Glass M, Huttelmaier S, Schutkowski M, Ihling C, Sinz A, Wingenfeld A, Mun A, Hatzfeld M
    J Cell Sci, 2013;126(0):1832-44.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  97. Selective tyrosine kinase inhibition of insulin-like growth factor-1 receptor inhibits human and mouse breast cancer-induced bone cell activity, bone remodeling, and osteolysis.
    Authors: Logan J, Sophocleous A, Marino S, Muir M, Brunton V, Idris A
    J Bone Miner Res, 2013;28(5):1229-42.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  98. Protein distribution during human erythroblast enucleation in vitro.
    Authors: Bell A, Satchwell T, Heesom K, Hawley B, Kupzig S, Hazell M, Mushens R, Herman A, Toye A
    PLoS ONE, 2013;8(4):e60300.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  99. Medial ganglionic eminence-like cells derived from human embryonic stem cells correct learning and memory deficits.
    Authors: Liu Y, Weick J, Liu H, Krencik R, Zhang X, Ma L, Zhou G, Ayala M, Zhang S
    Nat Biotechnol, 2013;31(5):440-7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  100. Targeting both IGF-1R and mTOR synergistically inhibits growth of renal cell carcinoma in vitro.
    Authors: Cardillo T, Trisal P, Arrojo R, Goldenberg D, Chang C
    BMC Cancer, 2013;13(0):170.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  101. Patient-specific iPSC-derived photoreceptor precursor cells as a means to investigate retinitis pigmentosa.
    Authors: Tucker, Budd A, Mullins, Robert F, Streb, Luan M, Anfinson, Kristin, Eyestone, Mari E, Kaalberg, Emily, Riker, Megan J, Drack, Arlene V, Braun, Terry A, Stone, Edwin M
    Elife, 2013;2(0):e00824.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  102. Role of IGF-1 pathway in lung fibroblast activation.
    Authors: Hung C, Rohani M, Lee S, Chen P, Schnapp L
    Respir Res, 2013;14(0):102.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  103. Rapid and efficient directed differentiation of human pluripotent stem cells into retinal pigmented epithelium.
    Authors: Buchholz, David E, Pennington, Britney, Croze, Roxanne, Hinman, Cassidy, Coffey, Peter J, Clegg, Dennis O
    Stem Cells Transl Med, 2013;2(5):384-93.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  104. The reactivity, distribution and abundance of Non-astrocytic Inner Retinal Glial (NIRG) cells are regulated by microglia, acute damage, and IGF1.
    Authors: Zelinka C, Scott M, Volkov L, Fischer A
    PLoS ONE, 2012;7(9):e44477.
    Species: Chicken
    Sample Types: In Vivo
    Applications: In Vivo
  105. Generation of glucose-responsive, insulin-producing cells from human umbilical cord blood-derived mesenchymal stem cells.
    Authors: Prabakar K, Dominguez-Bendala J, Molano R, Pileggi A, Villate S, Ricordi C, Inverardi L
    Cell Transplant, 2012;21(6):1321-39.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  106. Fibroblast growth factor-2 maintains a niche-dependent population of self-renewing highly potent non-adherent mesenchymal progenitors through FGFR2c.
    Authors: Di Maggio N, Mehrkens A, Papadimitropoulos A, Schaeren S, Heberer M, Banfi A, Martin I
    Stem Cells, 2012;30(7):1455-64.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  107. The hedgehog system in ovarian follicles of cattle selected for twin ovulations and births: evidence of a link between the IGF and hedgehog systems.
    Authors: Aad, Pauline, Echternkamp, Sherrill, Sypherd, David D, Schreiber, Nicole B, Spicer, Leon J
    Biol Reprod, 2012;87(4):79.
    Species: Bovine
    Sample Types: Whole Cells
    Applications: Bioassay
  108. Decorin antagonizes IGF receptor I (IGF-IR) function by interfering with IGF-IR activity and attenuating downstream signaling.
    Authors: Iozzo RV, Buraschi S, Genua M
    J. Biol. Chem., 2011;286(40):34712-21.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  109. IGFBP7 participates in the reciprocal interaction between acute lymphoblastic leukemia and BM stromal cells and in leukemia resistance to asparaginase.
    Authors: Laranjeira AB, de Vasconcellos JF, Sodek L, Spago MC, Fornazim MC, Tone LG, Brandalise SR, Nowill AE, Yunes JA
    Leukemia, 2011;26(5):1001-11.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  110. Molecular pharmacology and antitumor activity of PHT-427, a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor.
    Authors: Meuillet EJ, Zuohe S, Lemos R, Ihle N, Kingston J, Watkins R, Moses SA, Zhang S, Du-Cuny L, Herbst R, Jacoby JJ, Zhou LL, Ahad AM, Mash EA, Kirkpatrick DL, Powis G
    Mol. Cancer Ther., 2010;9(3):706-17.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  111. A novel type of glial cell in the retina is stimulated by insulin-like growth factor 1 and may exacerbate damage to neurons and Muller glia.
    Authors: Fischer AJ, Scott MA, Zelinka C, Sherwood P
    Glia, 2010;58(6):633-49.
    Species: Chicken
    Sample Types: In Vivo
    Applications: In Vivo
  112. Regulation of bone morphogenetic protein signalling in human pulmonary vascular development.
    Authors: Southwood M, Jeffery TK, Yang X, Upton PD, Hall SM, Atkinson C, Haworth SG, Stewart S, Reynolds PN, Long L, Trembath RC, Morrell NW
    J. Pathol., 2008;214(1):85-95.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  113. Development and validation of sandwich ELISA microarrays with minimal assay interference.
    Authors: Gonzalez RM, Seurynck-Servoss SL, Crowley SA
    J. Proteome Res., 2008;7(6):2406-14.
    Species: N/A
    Sample Types: N/A
    Applications: ELISA (Standard)
  114. Insulin-like growth factor-I receptor blockade by a specific tyrosine kinase inhibitor for human gastrointestinal carcinomas.
    Authors: Piao W, Wang Y, Adachi Y, Yamamoto H, Li R, Imsumran A, Li H, Maehata T, Ii M, Arimura Y, Lee CT, Shinomura Y, Carbone DP, Imai K
    Mol. Cancer Ther., 2008;7(6):1483-93.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  115. Growth hormone promotes lymphangiogenesis.
    Authors: Banziger-Tobler NE, Halin C, Kajiya K, Detmar M
    Am. J. Pathol., 2008;173(2):586-97.
    Species: N/A
    Sample Types: N/A
    Applications: Western Blot
  116. High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells.
    Authors: Desbordes SC, Placantonakis DG, Ciro A, Socci ND, Lee G, Djaballah H, Studer L
    Cell Stem Cell, 2008;2(6):602-12.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  117. GRP94 is essential for mesoderm induction and muscle development because it regulates insulin-like growth factor secretion.
    Authors: Wanderling S, Simen BB, Ostrovsky O, Ahmed NT, Vogen SM, Gidalevitz T, Argon Y
    Mol. Biol. Cell, 2007;18(10):3764-75.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  118. Insulin-like growth factor (IGF) 2 stimulates steroidogenesis and mitosis of bovine granulosa cells through the IGF1 receptor: role of follicle-stimulating hormone and IGF2 receptor.
    Authors: Spicer LJ, Aad PY
    Biol. Reprod., 2007;77(1):18-27.
    Species: Bovine
    Sample Types: Whole Cells
    Applications: Bioassay
  119. Growth differentiation factor-9 has divergent effects on proliferation and steroidogenesis of bovine granulosa cells.
    Authors: Spicer LJ, Aad PY, Allen D, Mazerbourg S, Hsueh AJ
    J. Endocrinol., 2006;189(2):329-39.
    Species: Bovine
    Sample Types: Whole Cells
    Applications: Bioassay
  120. Transforming growth factor-alpha: a major human serum factor that promotes human keratinocyte migration.
    Authors: Li Y, Fan J, Chen M, Li W, Woodley DT
    J. Invest. Dermatol., 2006;126(9):2096-105.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  121. Myelin formation during development of the CNS is delayed in matrix metalloproteinase-9 and -12 null mice.
    Authors: Larsen PH, DaSilva AG, Conant K, Yong VW
    J. Neurosci., 2006;26(8):2207-14.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  122. The effect of insulin-like growth factor-I on hepatocyte apoptosis after bile duct ligation in rat.
    Authors: Sheen-Chen SM, Ho HT, Chia-Pei L, Hung KS, Eng HL
    Dig. Dis. Sci., 2006;51(12):2220-4.
    Species: Rat
    Sample Types: In Vivo
    Applications: In Vivo
  123. Pretreatment of adult bone marrow mesenchymal stem cells with cardiomyogenic growth factors and repair of the chronically infarcted myocardium.
    Authors: Bartunek J, Croissant JD, Wijns W, Gofflot S, de Lavareille A, Vanderheyden M, Kaluzhny Y, Mazouz N, Willemsen P, Penicka M, Mathieu M, Homsy C, De Bruyne B, McEntee K, Lee IW, Heyndrickx GR
    Am. J. Physiol. Heart Circ. Physiol., 2006;292(2):H1095-104.
    Species: Canine
    Sample Types: Whole Cells
    Applications: Bioassay
  124. Insulin-like growth factor binding protein-4 (IGFBP-4) is a novel anti-angiogenic and anti-tumorigenic mediator secreted by dibutyryl cyclic AMP (dB-cAMP)-differentiated glioblastoma cells.
    Authors: Moreno MJ, Ball M, Andrade MF, McDermid A, Stanimirovic DB
    Glia, 2006;53(8):845-57.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  125. Increased extraocular muscle strength with direct injection of insulin-like growth factor-I.
    Authors: Anderson BC, Christiansen SP, Grandt S, Grange RW, McLoon LK
    Invest. Ophthalmol. Vis. Sci., 2006;47(6):2461-7.
    Species: Rabbit
    Sample Types: In Vivo
    Applications: In Vivo
  126. Growth hormone-induced stimulation of multilineage human hematopoiesis.
    Authors: Hanley MB, Napolitano LA, McCune JM
    Stem Cells, 2005;23(8):1170-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  127. Local delivery of growth factors from coated titanium plates increases osteotomy healing in rats.
    Authors: Wildemann B, Bamdad P, Holmer Ch, Haas NP, Raschke M, Schmidmaier G
    Bone, 2004;34(5):862-8.
    Species: Rat
    Sample Types: In Vivo
    Applications: In Vivo
  128. Quantification, localization, and expression of IGF-I and TGF-beta1 during growth factor-stimulated fracture healing.
    Authors: Brenner N, Huning M, Stange R
    Calcif. Tissue Int., 2004;74(4):388-97.
    Species: Rat
    Sample Types: In Vivo
    Applications: In Vivo
  129. Improvement of the developmental capacity of oocytes from prepubertal cattle by intraovarian insulin-like growth factor-I application.
    Authors: Oropeza A, Wrenzycki C, Herrmann D, Hadeler KG, Niemann H
    Biol. Reprod., 2004;70(6):1634-43.
    Species: Bovine
    Sample Types: In Vivo
    Applications: In Vivo
  130. The effects of in ovo rhIGF-I administration on expression of the growth hormone secretagogue receptor (GHSR) during chicken embryonic development.
    Authors: Gahr SA, Kocamis H, Richter JJ, Killefer J
    Growth Dev Aging, 2004;68(1):3-10.
    Species: Chicken
    Sample Types: In Vivo
    Applications: In Vivo
  131. Insulin growth factor-1 protects against excitotoxicity in the rat striatum.
    Authors: Escartin C, Boyer F, Bemelmans AP, Hantraye P, Brouillet E
    Neuroreport, 2004;15(14):2251-4.
    Species: Rat
    Sample Types: In Vivo
    Applications: In Vivo
  132. Chondrocyte response to growth factors is modulated by p38 mitogen-activated protein kinase inhibition.
    Authors: Studer RK, Bergman R, Stubbs T, Decker K
    Arthritis Res. Ther., 2004;6(1):R56-R64.
    Species: Rabbit
    Sample Types: Whole Cells
    Applications: Bioassay
  133. Detection of nitrotyrosine in aging and osteoarthritic cartilage: Correlation of oxidative damage with the presence of interleukin-1beta and with chondrocyte resistance to insulin-like growth factor 1.
    Authors: Loeser RF, Carlson CS, Del Carlo M, Cole A
    Arthritis Rheum., 2002;46(9):2349-57.
    Species: Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
    Sample Types: Whole Cells
    Applications: Bioassay
  134. Quantitative assessment of the integrity of the blood-retinal barrier in mice.
    Authors: Derevjanik NL, Vinores SA, Xiao WH, Mori K, Turon T, Hudish T, Dong S, Campochiaro PA
    Invest. Ophthalmol. Vis. Sci., 2002;43(7):2462-7.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  135. Activation of NF-kappaB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: therapeutic implications.
    Authors: Mitsiades CS, Mitsiades N, Poulaki V, Schlossman R, Akiyama M, Chauhan D, Hideshima T, Treon SP, Munshi NC, Richardson PG, Anderson KC
    Oncogene, 2002;21(37):5673-83.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  136. Reduction in the chondrocyte response to insulin-like growth factor 1 in aging and osteoarthritis: studies in a non-human primate model of naturally occurring disease.
    Authors: Loeser RF, 2018, Shanker G, Carlson CS, Gardin JF, Shelton BJ, Sonntag WE
    Arthritis Rheum., 2000;43(9):2110-20.
    Species: Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
    Sample Types: Whole Cells
    Applications: Bioassay
  137. Immediate early gene expression in dog thyrocytes in response to growth, proliferation, and differentiation stimuli.
    Authors: Deleu S, Pirson I, Clermont F, Nakamura T, Dumont JE, Maenhaut C
    J. Cell. Physiol., 1999;181(2):342-54.
    Species: Canine
    Sample Types: Whole Cells
    Applications: Bioassay
  138. Modeling the Mutational and Phenotypic Landscapes of Pelizaeus-Merzbacher Disease with Human iPSC-Derived Oligodendrocytes.
    Authors: Nevin Z, Factor D, Karl R, Douvaras P, Laukka J, Windrem M, Goldman S, Fossati V, Hobson G, Tesar P
    Am J Hum Genet, 0;100(4):617-634.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay

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Reviews for Recombinant Human IGF-I/IGF-1 Protein, CF

Average Rating: 4.6 (Based on 5 Reviews)

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Recombinant Human IGF-I/IGF-1 Protein, CF
By Anonymous on 01/09/2020
Application: Stem/Immune cell maintenance or differentiation
Reason for Rating: Performed very well in differentiating of human iPS cells into oligodendrocytes progenitor cells

Recombinant Human IGF-I/IGF-1 Protein, CF
By Anonymous on 10/09/2019
Application: CellProlif

Recombinant Human IGF-I/IGF-1 Protein, CF
By Anonymous on 07/26/2018
Application: Cell migration/motility

Recombinant Human IGF-I Protein, CF
By Anonymous on 02/26/2018
Application: Immunoassay Standard

Recombinant Human IGF-I Protein, CF
By Anonymous on 05/10/2017
Application: CellProlif