Recombinant Human IL-1 beta/IL-1F2 Protein, CF

(289 citations)   
  • Purity
    >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
  • Endotoxin Level
    <0.10 EU per 1 μg of the protein by the LAL method.
  • Activity
    Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells. Symons, J.A. et al. (1987) in Lymphokines and Interferons, a Practical Approach. Clemens, M.J. et al. (eds): IRL Press. 272. The ED50 for this effect is <12 pg/mL.
    The specific activity of recombinant human IL-1 beta is approximately 1.4 x 105 IU/μg, which is calibrated against recombinant human IL-1 beta WHO International Standard (NIBSC code: 86/680).
  • Source
    E. coli-derived Ala117-Ser269
  • Accession #
  • N-terminal Sequence
    Analysis
    Ala117 & Pro118
  • Predicted Molecular Mass
    17 kDa
Carrier Free
What does CF mean?
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
What formulation is right for me?
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
201-LB/CF
 
201-LB
Formulation Supplied as a 0.2 μm filtered solution in PBS.
Formulation Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Reconstitution Reconstitute at 25 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after opening.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Data Images
Recombinant Human IL-1 beta /IL-1F2 (Catalog # 201-LB/CF) stimulates cell proliferation of the D10.G4.1 mouse helper T cell line. The ED50 for this effect is 12 pg/mL.
1 μg/lane of Recombinant Human IL-1 beta /IL-1F2 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 17 kDa.
Background: IL-1 beta/IL-1F2

IL-1 is a name that designates two pleiotropic cytokines, IL-1 alpha (IL-1F1) and IL-1 beta (IL-1F2), which are the products of distinct genes. IL-1 alpha and IL-1 beta are structurally related polypeptides that share approximately 21% amino acid (aa) identity in human. Both proteins are produced by a wide variety of cells in response to inflammatory agents, infections, or microbial endotoxins. While IL-1 alpha and IL-1 beta are regulated independently, they bind to the same receptor and exert identical biological effects. IL-1 RI binds directly to IL-1 alpha or IL-1 beta and then associates with IL-1 R accessory protein (IL-1 R3/IL-1 R AcP) to form a high-affinity receptor complex that is competent for signal transduction. IL-1 RII has high affinity for IL-1 beta but functions as a decoy receptor and negative regulator of IL-1 beta activity. IL-1ra functions as a competitive antagonist by preventing IL-1 alpha and IL-1 beta from interacting with IL-1 RI (1-4). The human IL-1 beta cDNA encodes a 269 aa precursor. A 116 aa propeptide is cleaved intracellularly by the cysteine protease IL-1 beta -converting enzyme (Caspase-1/ICE) to generate the active cytokine (5-7). The 17 kDa mature human IL-1 beta shares 96% aa sequence identity with rhesus and 67%-78% with canine, cotton rat, equine, feline, mouse, porcine, and rat IL-1 beta.

  • References:
    1. Allan, S.M. et al. (2005) Nat. Rev. Immunol. 5:629.
    2. Boraschi, D. and A. Tagliabue (2006) Vitam. Horm. 74:229.
    3. Kornman, K.S. (2006) Am. J. Clin. Nutr. 83:475S.
    4. Isoda, K. and F. Ohsuzu (2006) J. Atheroscler. Thromb. 13:21.
    5. March, C.J. et al. (1985) Nature 315:641.
    6. Auron, P.E. et al. (1984) Proc. Natl. Acad. Sci. 81:7907.
    7. Martinon, F. and J. Tschopp (2007) Cell Death Differ. 14:10.
  • Long Name:
    Interleukin 1 beta
  • Entrez Gene IDs:
    3553 (Human); 16176 (Mouse); 24494 (Rat); 397122 (Porcine); 403974 (Canine); 100034237 (Equine); 100135556 (Guinea Pig)
  • Alternate Names:
    catabolin; IL1 beta; IL-1 beta; IL-1; IL1B; IL-1b; IL1-BETA; IL-1F2; IL1F2IL-1 beta; interleukin 1, beta; interleukin-1 beta; preinterleukin 1 beta; pro-interleukin-1-beta
Related Research Areas
Citations:

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

289 Citations: Showing 1 - 10
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  1. Autophagy gene ATG7 regulates ultraviolet radiation-induced inflammation and skin tumorigenesis
    Authors: L Qiang, A Sample, CR Shea, K Soltani, KF Macleod, YY He
    Autophagy, 2017;0(0):0.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  2. The autocrine role of proteoglycan-4 (PRG4) in modulating osteoarthritic synoviocyte proliferation and expression of matrix degrading enzymes
    Authors: A Alquraini, M Jamal, L Zhang, T Schmidt, GD Jay, KA Elsaid
    Arthritis Res. Ther., 2017;19(1):89.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  3. A Synthetic Mammalian Therapeutic Gene Circuit for Sensing and Suppressing Inflammation
    Authors: A Smole, D Lain??ek, U Bezeljak, S Horvat, R Jerala
    Mol. Ther, 2017;25(1):102-119.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay Standard
  4. Whole-Genome Sequencing of a Family with Hereditary Pulmonary Alveolar Proteinosis Identifies a Rare Structural Variant Involving CSF2RA/CRLF2/IL3RA Gene Disruption
    Authors: CY Chiu, SC Su, WL Fan, SH Lai, MH Tsai, SH Chen, KS Wong, WH Chung
    Sci Rep, 2017;7(0):43469.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  5. Neuropilin-1 Is Expressed on Lymphoid Tissue Residing LTi-like Group 3 Innate Lymphoid Cells and Associated with Ectopic Lymphoid Aggregates
    Authors: MM Shikhagaie, ÅK Björklund, J Mjösberg, JS Erjefält, AS Cornelisse, XR Ros, SM Bal, JJ Koning, RE Mebius, M Mori, M Bruchard, B Blom, H Spits
    Cell Rep, 2017;18(7):1761-1773.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  6. Retinoic-acid-orphan-receptor-C inhibition suppresses Th17 cells and induces thymic aberrations
    Authors: C Guntermann, A Piaia, ML Hamel, D Theil, T Rubic-Schn, A Del Rio-Es, L Dong, A Billich, K Kaupmann, J Dawson, K Hoegenauer, D Orain, S Hintermann, R Stringer, DD Patel, A Doelemeyer, M Deurinck, J Schümann
    JCI Insight, 2017;2(5):e91127.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  7. The symbiotic bacterial surface factor polysaccharide A on Bacteroides fragilis inhibits IL-1?-induced inflammation in human fetal enterocytes via toll receptors 2 and 4
    Authors: F Jiang, D Meng, M Weng, W Zhu, W Wu, D Kasper, WA Walker
    PLoS ONE, 2017;12(3):e0172738.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  8. ICOSL expression in human bone marrow-derived mesenchymal stem cells promotes induction of regulatory T cells
    Authors: HJ Lee, SN Kim, MS Jeon, T Yi, SU Song
    Sci Rep, 2017;7(0):44486.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  9. Human Cytomegalovirus MicroRNAs miR-US5-1 and miR-UL112-3p Block Proinflammatory Cytokine Production in Response to NF-?B-Activating Factors through Direct Downregulation of IKK? and IKK?
    Authors: MH Hancock, LM Hook, J Mitchell, JA Nelson
    MBio, 2017;8(2):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  10. Genomic reprograming analysis of the Mesothelial to Mesenchymal Transition identifies biomarkers in peritoneal dialysis patients
    Authors: V Ruiz-Carpi, P Sandoval, A Aguilera, P Albar-Vizc, ML Perez-Loza, GT González-M, A Acuña-Ruiz, J García-Can, P Botías, MA Bajo, R Selgas, JA Sánchez-To, J Passlick-D, D Piecha, J Büchel, S Steppan, M López-Cabr
    Sci Rep, 2017;7(0):44941.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  11. IL-24 Promotes Pseudomonas aeruginosa Keratitis in C57BL/6 Mouse Corneas
    Authors: BX Ross, N Gao, X Cui, TJ Standiford, J Xu, FX Yu
    J. Immunol, 2017;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  12. Interleukin-1 primes human mesenchymal stem cells towards an anti-inflammatory and pro-trophic phenotype in vitro
    Authors: E Redondo-Ca, C Cunningham, J Miller, L Martuscell, S Aoulad-Ali, NJ Rothwell, CM Kielty, SM Allan, E Pinteaux
    Stem Cell Res Ther, 2017;8(1):79.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  13. Interactions between Sirt1 and MAPKs regulate astrocyte activation induced by brain injury in vitro and in vivo
    Authors: D Li, N Liu, HH Zhao, X Zhang, H Kawano, L Liu, L Zhao, HP Li
    J Neuroinflammation, 2017;14(1):67.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  14. Siglec-7 restores ?-cell function and survival and reduces inflammation in pancreatic islets from patients with diabetes
    Authors: G Dharmadhik, K Stolz, M Hauke, NG Morgan, A Varki, E de Koning, S Kelm, K Maedler
    Sci Rep, 2017;7(0):45319.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  15. Microglia-derived IL-1? promotes chemokine expression by M�ller cells and RPE in focal retinal degeneration
    Authors: R Natoli, N Fernando, M Madigan, JA Chu-Tan, K Valter, J Provis, M Rutar
    Mol Neurodegener, 2017;12(1):31.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  16. DAMPs Synergize with Cytokines or Fibronectin Fragment on Inducing Chondrolysis but Lose Effect When Acting Alone
    Authors: L Ding, JA Buckwalter, JA Martin
    Mediators Inflamm., 2017;2017(0):2642549.
    Species: Bovine
    Sample Type: Whole Cells
    Application: Bioassay
  17. Soya-cerebroside, an extract of Cordyceps militaris, suppresses monocyte migration and prevents cartilage degradation in inflammatory animal models
    Authors: SC Liu, CP Chiu, CH Tsai, CY Hung, TM Li, YC Wu, CH Tang
    Sci Rep, 2017;7(0):43205.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  18. The transcriptional coactivator TAZ regulates reciprocal differentiation of TH17 cells and Treg cells
    Authors: J Geng, S Yu, H Zhao, X Sun, X Li, P Wang, X Xiong, L Hong, C Xie, J Gao, Y Shi, J Peng, RL Johnson, N Xiao, L Lu, J Han, D Zhou, L Chen
    Nat. Immunol., 2017;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  19. DNA methyltransferase 3b regulates articular cartilage homeostasis by altering metabolism
    Authors: J Shen, C Wang, D Li, T Xu, J Myers, JM Ashton, T Wang, MJ Zuscik, A McAlinden, RJ O'Keefe
    JCI Insight, 2017;2(12):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  20. The Role of Inflammation in ?-cell Dedifferentiation
    Authors: TM Nordmann, E Dror, F Schulze, S Traub, E Berishvili, C Barbieux, M Böni-Schne, MY Donath
    Sci Rep, 2017;7(1):6285.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  21. Sphingosine-1-Phosphate Mediates Fibrosis in Orbital Fibroblasts in Graves' Orbitopathy
    Authors: J Ko, MK Chae, JH Lee, EJ Lee, JS Yoon
    Invest. Ophthalmol. Vis. Sci., 2017;58(5):2544-2553.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  22. TLR7 Signaling Regulates Th17 Cells and Autoimmunity: Novel Potential for Autoimmune Therapy
    Authors: J Ye, Y Wang, X Liu, L Li, A Opejin, EC Hsueh, H Luo, T Wang, D Hawiger, G Peng
    J. Immunol., 2017;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  23. Transcriptional networks specifying homeostatic and inflammatory programs of gene expression in human aortic endothelial cells
    Authors: NT Hogan, MB Whalen, LK Stolze, NK Hadeli, MT Lam, JR Springstea, CK Glass, CE Romanoski
    Elife, 2017;6(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  24. TNF?-Induced Disruption of the Blood-Retinal Barrier In Vitro Is Regulated by Intracellular 3',5'-Cyclic Adenosine Monophosphate Levels
    Authors: AE van der Wi, IMC Vogels, CJF van Noorde, I Klaassen, RO Schlingema
    Invest. Ophthalmol. Vis. Sci., 2017;58(9):3496-3505.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  25. Interleukin-20 is triggered by TLR ligands and associates with disease activity in patients with rheumatoid arthritis
    Authors: L Šenolt, K Prajzlerov, H Hulejová, B Šumová, M Filková, D Veigl, K Pavelka, J Vencovský
    Cytokine, 2017;97(0):187-192.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  26. MicroRNA-29b Contributes to Collagens Imbalance in Human Osteoarthritic and Dedifferentiated Articular Chondrocytes
    Authors: D Moulin, V Salone, M Koufany, T Clément, I Behm-Ansma, C Branlant, B Charpentie, JY Jouzeau
    Biomed Res Int, 2017;2017(0):9792512.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  27. RANK/RANKL/OPG system in the intervertebral disc
    Authors: N Takegami, K Akeda, J Yamada, T Sano, K Murata, J Huang, K Masuda, A Sudo
    Arthritis Res. Ther., 2017;19(1):121.
    Species: Rat
    Sample Type: Whole Cells
    Application: Bioassay
  28. Frontline Science: c-Myc regulates P-selectin glycoprotein ligand-1 expression in monocytes during HIV-1 infection
    Authors: R Connor, LD Jones, X Qiu, J Thakar, SB Maggirwar
    J. Leukoc. Biol., 2017;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  29. An activated Th17-prone T cell subset involved in chronic graft-versus-host disease sensitive to pharmacological inhibition
    Authors: E Forcade, K Paz, R Flynn, B Griesenaue, T Amet, W Li, L Liu, G Bakoyannis, D Jiang, HW Chu, M Lobera, J Yang, DS Wilkes, J Du, K Gartlan, GR Hill, KP MacDonald, EL Espada, P Blanco, JS Serody, J Koreth, CS Cutler, JH Antin, RJ Soiffer, J Ritz, S Paczesny, BR Blazar
    JCI Insight, 2017;2(12):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  30. Differentiation of Inflammation-Responsive Astrocytes from Glial Progenitors Generated from Human Induced Pluripotent Stem Cells
    Authors: R Santos, KC Vadodaria, BN Jaeger, A Mei, S Lefcochilo, APD Mendes, G Erikson, M Shokhirev, L Randolph-M, C Fredlender, S Dave, R Oefner, C Fitzpatric, M Pena, JJ Barron, M Ku, AM Denli, BE Kerman, P Charnay, JR Kelsoe, MC Marchetto, FH Gage
    Stem Cell Reports, 2017;8(6):1757-1769.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  31. Rebamipide Attenuates Mandibular Condylar Degeneration in a Murine Model of TMJ-OA by Mediating a Chondroprotective Effect and by Downregulating RANKL-Mediated Osteoclastogenesis
    PLoS ONE, 2016;11(4):e0154107.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  32. Expression of human gene coding ROR?T receptor depends on the Sp2 transcription factor
    Authors: Marcin Ratajewski
    J Leukoc Biol, 2016;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  33. Epithelium-specific Ets transcription factor-1 acts as a negative regulator of cyclooxygenase-2 in human rheumatoid arthritis synovial fibroblasts
    Authors: Chan-Mi Lee
    Cell Biosci, 2016;6(0):43.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  34. Tissue factor is induced by interleukin-33 in human endothelial cells: a new link between coagulation and inflammation
    Sci Rep, 2016;6(0):25171.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  35. IL-3 Decreases Cartilage Degeneration by Downregulating Matrix Metalloproteinases and Reduces Joint Destruction in Osteoarthritic Mice
    J Immunol, 2016;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  36. Silk-based blood stabilization for diagnostics
    Proc Natl Acad Sci USA, 2016;113(21):5892-7.
    Species: Human
    Sample Type: Urine
    Application: Bioassay
  37. IL-1?, IL-4 and IL-12 control the fate of group 2 innate lymphoid cells in human airway inflammation in the lungs
    Authors: SM Bal, JH Bernink, M Nagasawa, J Groot, MM Shikhagaie, K Golebski, CM van Drunen, R Lutter, RE Jonkers, P Hombrink, M Bruchard, J Villaudy, JM Munneke, W Fokkens, JS Erjefält, H Spits, XR Ros
    Nat Immunol, 2016;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  38. Analysis of CXCR5(+)Th17 cells in relation to disease activity and TNF inhibitor therapy in Rheumatoid Arthritis
    Sci Rep, 2016;6(0):39474.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  39. Identification of microRNA-181a-5p and microRNA-4454 as mediators of facet cartilage degeneration
    JCI Insight, 2016;1(12):e86820.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  40. Activated monocytes resist elimination by retinal pigment epithelium and downregulate their OTX2 expression via TNF-?
    Aging Cell, 2016;0(0):.
    Species: Porcine
    Sample Type: Whole Cells
    Application: Bioassay
  41. Endothelial Cell Activation is Regulated by Epidermal Growth Factor-Like Domain 7 (Egfl7) during Inflammation
    J Biol Chem, 2016;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  42. Signaling and Immunoresolving Actions of Resolvin D1 in Inflamed Human Visceral Adipose Tissue
    J Immunol, 2016;0(0):.
    Species: Human
    Sample Type: Whole Tissue
    Application: Bioassay
  43. Pharmacologic modulation of ROR?t translates to efficacy in preclinical and translational models of psoriasis and inflammatory arthritis
    Sci Rep, 2016;6(0):37977.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  44. P311 induces the transdifferentiation of epidermal stem cells to myofibroblast-like cells by stimulating transforming growth factor ?1 expression
    Stem Cell Res Ther, 2016;7(1):175.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  45. Preferential Induction of the T Cell Auxiliary Signaling Molecule B7-H3 on Synovial Monocytes in Rheumatoid Arthritis
    Authors: BR Yoon, YH Chung, SJ Yoo, K Kawara, J Kim, IS Yoo, CG Park, SW Kang, WW Lee
    J. Biol. Chem, 2016;291(8):4048-57.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  46. Structural and functional attributes of the Interleukin-36 receptor
    Authors: Guanghui Yi
    J Biol Chem, 2016;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  47. DUSP1 maintains IRF1 and leads to increased expression of IRF1-dependent genes: A mechanism promoting glucocorticoid-insensitivity
    J Biol Chem, 2016;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  48. Human Mesenchymal Stem Cells Impact Th17 and Th1 Responses Through a Prostaglandin E2 and Myeloid-Dependent Mechanism
    Stem Cells Transl Med, 2016;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  49. Ubiquitin D regulates IRE1?/JNK-dependent apoptosis in pancreatic beta cells
    Authors: F Brozzi, S Gerlo, FA Grieco, M Juusola, A Balhuizen, S Lievens, C Gysemans, M Bugliani, C Mathieu, P Marchetti, J Tavernier, DL Eizirik
    J Biol Chem, 2016;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  50. Immunomodulation by mesenchymal stem cells in treating human autoimmune disease-associated lung fibrosis
    Authors: M Liu, X Zeng, J Wang, Z Fu, J Wang, M Liu, D Ren, B Yu, L Zheng, X Hu, W Shi, J Xu
    Stem Cell Res Ther, 2016;7(1):63.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  51. Innate lymphoid cells are expanded and functionally altered in chronic lymphocytic leukemia
    Authors: I de Weerdt, V van Hoeven, JM Munneke, S Endstra, T Hofland, MD Hazenberg, AP Kater
    Haematologica, 2016;101(11):e461-e464.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  52. Up-Regulation of Human Inducible Nitric Oxide Synthase by p300 Transcriptional Complex.
    Authors: Guo Z, Zheng L, Liao X, Geller D
    PLoS ONE, 2016;11(1):e0146640.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  53. Fibroblasts profiling in scarring trachoma identifies IL-6 as a functional component of a fibroblast-macrophage pro-fibrotic and pro-inflammatory feedback loop
    Authors: Jenny Z Kechagia
    Sci Rep, 2016;6(0):28261.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  54. Differential expression of the immunosuppressive enzyme IL4I1 in human induced Aiolos+, but not natural Helios+, FOXP3+ Treg cells.
    Authors: Scarlata C, Celse C, Pignon P, Ayyoub M, Valmori D
    Eur J Immunol, 2015;45(2):474-9.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  55. Curcuminoids extract, hydrolyzed collagen and green tea extract synergically inhibit inflammatory and catabolic mediator's synthesis by normal bovine and osteoarthritic human chondrocytes in monolayer.
    Authors: Comblain F, Sanchez C, Lesponne I, Balligand M, Serisier S, Henrotin Y
    PLoS ONE, 2015;10(3):e0121654.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  56. Broadly-specific cytotoxic T cells targeting multiple HIV antigens are expanded from HIV+ patients: implications for immunotherapy.
    Authors: Lam, Sharon, Sung, Julia, Cruz, Conrad, Castillo-Caro, Paul, Ngo, Minhtran, Garrido, Carolina, Kuruc, Joann, Archin, Nancie, Rooney, Cliona, Margolis, David, Bollard, Catherin
    Mol Ther, 2015;23(2):387-95.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  57. Anti-apoptotic NF-kappaB and "gain of function" mutp53 in concert act pro-apoptotic in response to UVB+IL-1 via enhanced TNF production.
    Authors: Muller I, Beissert S, Kulms D
    J Invest Dermatol, 2015;135(3):851-60.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  58. Activation of toll like receptor 4 attenuates GABA synthesis and postsynaptic GABA receptor activities in the spinal dorsal horn via releasing interleukin-1 beta.
    Authors: Yan X, Jiang E, Weng H
    J Neuroinflammation, 2015;12(0):222.
    Species: Mouse
    Sample Type: Whole Tissue
    Application: Bioassay
  59. ChemR23, the receptor for chemerin and resolvin E1, is expressed and functional on M1 but not on M2 macrophages.
    Authors: Herova M, Schmid M, Gemperle C, Hersberger M
    J Immunol, 2015;194(5):2330-7.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  60. Characterization of pancreatic NMDA receptors as possible drug targets for diabetes treatment.
    Authors: Marquard J, Otter S, Welters A, Stirban A, Fischer A, Eglinger J, Herebian D, Kletke O, Klemen M, Stozer A, Wnendt S, Piemonti L, Kohler M, Ferrer J, Thorens B, Schliess F, Rupnik M, Heise T, Berggren P, Klocker N, Meissner T, Mayatepek E, Eberhard D, Kragl M, Lammert E
    Nat Med, 2015;21(4):363-72.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  61. The expression and regulation of chemerin in the epidermis.
    Authors: Banas M, Zegar A, Kwitniewski M, Zabieglo K, Marczynska J, Kapinska-Mrowiecka M, LaJevic M, Zabel B, Cichy J
    PLoS ONE, 2015;10(2):e0117830.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  62. Adrenal steroids modulate the immune response during Brucella abortus infection by a mechanism that depends on the regulation of cytokine production.
    Authors: Gentilini M, Velasquez L, Barrionuevo P, Arriola Benitez P, Giambartolomei G, Delpino M
    Infect Immun, 2015;83(5):1973-82.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  63. Generation of articular chondrocytes from human pluripotent stem cells.
    Authors: Craft A, Rockel J, Nartiss Y, Kandel R, Alman B, Keller G
    Nat Biotechnol, 2015;33(6):638-45.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  64. Cancer-testis antigen SLLP1 represents a promising target for the immunotherapy of multiple myeloma.
    Authors: Yousef S, Heise J, Lajmi N, Bartels K, Kroger N, Luetkens T, Atanackovic D
    J Transl Med, 2015;13(0):197.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  65. Interleukin-1 beta enhances human multipotent mesenchymal stromal cell proliferative potential and their ability to maintain hematopoietic precursor cells.
    Authors: Bigildeev A, Zezina E, Shipounova I, Drize N
    Cytokine, 2015;71(2):246-54.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  66. Inherited IL-17RC deficiency in patients with chronic mucocutaneous candidiasis.
    Authors: Ling Y, Cypowyj S, Aytekin C, Galicchio M, Camcioglu Y, Nepesov S, Ikinciogullari A, Dogu F, Belkadi A, Levy R, Migaud M, Boisson B, Bolze A, Itan Y, Goudin N, Cottineau J, Picard C, Abel L, Bustamante J, Casanova J, Puel A
    J Exp Med, 2015;212(5):619-31.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  67. Human HOIP and LUBAC deficiency underlies autoinflammation, immunodeficiency, amylopectinosis, and lymphangiectasia.
    Authors: Boisson B, Laplantine E, Dobbs K, Cobat A, Tarantino N, Hazen M, Lidov H, Hopkins G, DU L, Belkadi A, Chrabieh M, Itan Y, Picard C, Fournet J, Eibel H, Tsitsikov E, Pai S, Abel L, Al-Herz W, Casanova J, Israel A, Notarangelo L
    J Exp Med, 2015;212(6):939-51.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  68. Transforming Growth Factor-beta and Interleukin-1beta Signaling Pathways Converge on the Chemokine CCL20 Promoter.
    Authors: Brand O, Somanath S, Moermans C, Yanagisawa H, Hashimoto M, Cambier S, Markovics J, Bondesson A, Hill A, Jablons D, Wolters P, Lou J, Marks J, Baron J, Nishimura S
    J Biol Chem, 2015;290(23):14717-28.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  69. Eupatilin Exerts Antinociceptive and Chondroprotective Properties in a Rat Model of Osteoarthritis by Downregulating Oxidative Damage and Catabolic Activity in Chondrocytes.
    Authors: Jeong J, Moon S, Jhun J, Yang E, Cho M, Min J
    PLoS ONE, 2015;10(6):e0130882.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  70. IL-4 Downregulates IL-1beta and IL-6 and Induces GATA3 in Psoriatic Epidermal Cells: Route of Action of a Th2 Cytokine.
    Authors: Onderdijk A, Baerveldt E, Kurek D, Kant M, Florencia E, Debets R, Prens E
    J Immunol, 2015;195(4):1744-52.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  71. Priming of Human Resting NK Cells by Autologous M1 Macrophages via the Engagement of IL-1beta, IFN-beta, and IL-15 Pathways.
    Authors: Mattiola I, Pesant M, Tentorio P, Molgora M, Marcenaro E, Lugli E, Locati M, Mavilio D
    J Immunol, 2015;195(6):2818-28.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  72. PHLDA1 expression is controlled by an estrogen receptor-NFkappaB-miR-181 regulatory loop and is essential for formation of ER+ mammospheres.
    Authors: Kastrati I, Canestrari E, Frasor J
    Oncogene, 2015;34(18):2309-16.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  73. Pro-Inflammatory Cytokine IL-1beta Up-Regulates CXC Chemokine Receptor 4 via Notch and ERK Signaling Pathways in Tongue Squamous Cell Carcinoma.
    Authors: Sun Y, Zhu D, Wang G, Wang D, Zhou H, Liu X, Jiang M, Liao L, Zhou Z, Hu J
    PLoS ONE, 2015;10(7):e0132677.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  74. Human group3 innate lymphoid cells express DR3 and respond to TL1A with enhanced IL-22 production and IL-2-dependent proliferation.
    Authors: Ahn Y, Weeres M, Neulen M, Choi J, Kang S, Heo D, Bergerson R, Blazar B, Miller J, Verneris M
    Eur J Immunol, 2015;45(8):2335-42.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  75. Signal Transduction and Intracellular Trafficking by the Interleukin 36 Receptor.
    Authors: Saha S, Singh D, Raymond E, Ganesan R, Caviness G, Grimaldi C, Woska J, Mennerich D, Brown S, Mbow M, Kao C
    J Biol Chem, 2015;290(39):23997-4006.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  76. Ultraviolet light converts propranolol, a nonselective beta-blocker and potential lupus-inducing drug, into a proinflammatory AhR ligand.
    Authors: Dorgham K, Amoura Z, Parizot C, Arnaud L, Frances C, Pionneau C, Devilliers H, Pinto S, Zoorob R, Miyara M, Larsen M, Yssel H, Gorochov G, Mathian A
    Eur J Immunol, 2015;45(11):3174-87.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  77. Short term exposure of beta cells to low concentrations of interleukin-1beta improves insulin secretion through focal adhesion and actin remodeling and regulation of gene expression.
    Authors: Arous C, Ferreira P, Dermitzakis E, Halban P
    J Biol Chem, 2015;290(10):6653-69.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  78. Cytokine-induced loss of glucocorticoid function: effect of kinase inhibitors, long-acting beta(2)-adrenoceptor [corrected] agonist and glucocorticoid receptor ligands.
    Authors: Rider C, Shah S, Miller-Larsson A, Giembycz M, Newton R
    PLoS ONE, 2015;10(1):e0116773.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  79. Human osteoarthritic cartilage shows reduced in vivo expression of IL-4, a chondroprotective cytokine that differentially modulates IL-1beta-stimulated production of chemokines and matrix-degrading enzymes in vitro.
    Authors: Assirelli E, Pulsatelli L, Dolzani P, Platano D, Olivotto E, Filardo G, Trisolino G, Facchini A, Borzi R, Meliconi R
    PLoS ONE, 2014;9(5):e96925.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  80. CD24-triggered caspase-dependent apoptosis via mitochondrial membrane depolarization and reactive oxygen species production of human neutrophils is impaired in sepsis.
    Authors: Parlato M, Souza-Fonseca-Guimaraes F, Philippart F, Misset B, Adib-Conquy M, Cavaillon J
    J Immunol, 2014;192(5):2449-59.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  81. Improving membrane based multiplex immunoassays for semi-quantitative detection of multiple cytokines in a single sample.
    Authors: Altara, Raffaele, Manca, Marco, Hessel, Marleen, Janssen, Ben J, Struijker-Boudier, Harry H, Hermans, Rob J J, Blankesteijn, W Matthi
    BMC Biotechnol, 2014;14(0):63.
    Species: N/A
    Sample Type: N/A
    Application: ELISA Standard
  82. p38-Mediated phosphorylation of Eps15 endocytic adaptor protein.
    Authors: Zhou Y, Tanaka T, Sugiyama N, Yokoyama S, Kawasaki Y, Sakuma T, Ishihama Y, Saiki I, Sakurai H
    FEBS Lett, 2014;588(1):131-7.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  83. Hypercytotoxicity and rapid loss of NKp44+ innate lymphoid cells during acute SIV infection.
    Authors: Li H, Richert-Spuhler L, Evans T, Gillis J, Connole M, Estes J, Keele B, Klatt N, Reeves R
    PLoS Pathog, 2014;10(12):e1004551.
    Species: Primate - Macaca mulatta (Rhesus Macaque)
    Sample Type: Whole Cells
    Application: Bioassay
  84. Interleukin 7 plays a role in T lymphocyte apoptosis inhibition driven by mesenchymal stem cell without favoring proliferation and cytokines secretion.
    Authors: Normanton M, Alvarenga H, Hamerschlak N, Ribeiro A, Kondo A, Rizzo L, Marti L
    PLoS ONE, 2014;9(9):e106673.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  85. Role of Ca2+/calmodulin-dependent kinase II-IRAK1 interaction in LMP1-induced NF-kappaB activation.
    Authors: Kim J, Kim S, Lim S, Kieff E, Song Y
    Mol Cell Biol, 2014;34(3):325-34.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  86. IL-1beta promotes the differentiation of polyfunctional human CCR6+CXCR3+ Th1/17 cells that are specific for pathogenic and commensal microbes.
    Authors: Duhen T, Campbell D
    J Immunol, 2014;193(1):120-9.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  87. Independent adipogenic and contractile properties of fibroblasts in Graves' orbitopathy: an in vitro model for the evaluation of treatments.
    Authors: Li H, Fitchett C, Kozdon K, Jayaram H, Rose G, Bailly M, Ezra D
    PLoS ONE, 2014;9(4):e95586.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  88. Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells.
    Authors: Kofler D, Marson A, Dominguez-Villar M, Xiao S, Kuchroo V, Hafler D
    J Clin Invest, 2014;124(6):2513-22.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  89. Comparison of osteogenic differentiation of embryonic stem cells and primary osteoblasts revealed by responses to IL-1beta, TNF-alpha, and IFN-gamma.
    Authors: Sidney L, Kirkham G, Buttery L
    Stem Cells Dev, 2014;23(6):605-17.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  90. Interleukin-6 signaling drives fibrosis in unresolved inflammation.
    Authors: Fielding C, Jones G, McLoughlin R, McLeod L, Hammond V, Uceda J, Williams A, Lambie M, Foster T, Liao C, Rice C, Greenhill C, Colmont C, Hams E, Coles B, Kift-Morgan A, Newton Z, Craig K, Williams J, Williams G, Davies S, Humphreys I, O'Donnell V, Taylor P, Jenkins B, Topley N, Jones S
    Immunity, 2014;40(1):40-50.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  91. The aryl hydrocarbon receptor is functionally upregulated early in the course ofvhuman T-cell activation.
    Authors: Prigent L, Robineau M, Jouneau S, Morzadec C, Louarn L, Vernhet L, Fardel O, Sparfel L
    Eur J Immunol, 2014;44(5):1330-40.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  92. Thymic stromal lymphopoietin links keratinocytes and dendritic cell-derived IL-23 in patients with psoriasis.
    Authors: Volpe E, Pattarini L, Martinez-Cingolani C, Meller S, Donnadieu M, Bogiatzi S, Fernandez M, Touzot M, Bichet J, Reyal F, Paronetto M, Chiricozzi A, Chimenti S, Nasorri F, Cavani A, Kislat A, Homey B, Soumelis V
    J Allergy Clin Immunol, 2014;134(2):373-81.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  93. MST1 is a key regulator of beta cell apoptosis and dysfunction in diabetes.
    Authors: Ardestani, Amin, Paroni, Federico, Azizi, Zahra, Kaur, Supreet, Khobragade, Vrushali, Yuan, Ting, Frogne, Thomas, Tao, Wufan, Oberholzer, Jose, Pattou, Francois, Kerr Conte, Julie, Maedler, Kathrin
    Nat Med, 2014;20(4):385-97.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  94. A polysaccharide virulence factor from Aspergillus fumigatus elicits anti-inflammatory effects through induction of Interleukin-1 receptor antagonist.
    Authors: Gresnigt M, Bozza S, Becker K, Joosten L, Abdollahi-Roodsaz S, van der Berg W, Dinarello C, Netea M, Fontaine T, De Luca A, Moretti S, Romani L, Latge J, van de Veerdonk F
    PLoS Pathog, 2014;10(3):e1003936.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  95. Enriched protein screening of human bone marrow mesenchymal stromal cell secretions reveals MFAP5 and PENK as novel IL-10 modulators.
    Authors: Milwid, Jack M, Elman, Jessica, Li, Matthew, Shen, Keyue, Manrai, Arjun, Gabow, Aaron, Yarmush, Joshua, Jiao, Yunxin, Fletcher, Anne, Lee, Jungwoo, Cima, Michael, Yarmush, Martin L, Parekkadan, Biju
    Mol Ther, 2014;22(5):999-1007.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  96. Pathogen sensing pathways in human embryonic stem cell derived-endothelial cells: role of NOD1 receptors.
    Authors: Reed, Daniel M, Foldes, Gabor, Gatheral, Timothy, Paschalaki, Koralia, Lendvai, Zsuzsann, Bagyura, Zsolt, Nemeth, Tamas, Skopal, Judit, Merkely, Bela, Telcian, Aurica G, Gogsadze, Leila, Edwards, Michael, Gough, Peter J, Bertin, John, Johnston, Sebastia, Harding, Sian E, Mitchell, Jane A
    PLoS ONE, 2014;9(4):e91119.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  97. Overexpression of CCN3 inhibits inflammation and progression of atherosclerosis in apolipoprotein E-deficient mice.
    Authors: Liu J, Ren Y, Kang L, Zhang L
    PLoS ONE, 2014;9(4):e94912.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  98. IL-1beta-induced activation of p38 promotes metastasis in gastric adenocarcinoma via upregulation of AP-1/c-fos, MMP2 and MMP9.
    Authors: Huang Q, Lan F, Wang X, Yu Y, Ouyang X, Zheng F, Han J, Lin Y, Xie Y, Xie F, Liu W, Yang X, Wang H, Dong L, Wang L, Tan J
    Mol Cancer, 2014;13(0):18.
  99. Distinct mechanisms of induction of hepatic growth hormone resistance by endogenous IL-6, TNF-alpha, and IL-1beta.
    Authors: Zhao Y, Xiao X, Frank S, Lin H, Xia Y
    Am J Physiol Endocrinol Metab, 2014;307(2):E186-98.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  100. Inhibitory effects of prostaglandin E2 on collagen synthesis and cell proliferation in human stellate cells from pancreatic head adenocarcinoma.
    Authors: Pomianowska E, Sandnes D, Grzyb K, Schjolberg A, Aasrum M, Tveteraas I, Tjomsland V, Christoffersen T, Gladhaug I
    BMC Cancer, 2014;14(0):413.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  101. Pigment epithelium-derived factor (PEDF) suppresses IL-1beta-mediated c-Jun N-terminal kinase (JNK) activation to improve hepatocyte insulin signaling.
    Authors: Gattu A, Birkenfeld A, Iwakiri Y, Jay S, Saltzman M, Doll J, Protiva P, Samuel V, Crawford S, Chung C
    Endocrinology, 2014;155(4):1373-85.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  102. Additive effects of EGF and IL-1beta regulate tumor cell migration and invasion in gastric adenocarcinoma via activation of ERK1/2.
    Authors: Han J, Xie Y, Lan F, Yu Y, Liu W, Chen J, Zheng F, Ouyang X, Lin X, Lin Y, Huang Q, Wang L, Tan J
    Int J Oncol, 2014;45(1):291-301.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  103. Nanoparticle-mediated combinatorial targeting of multiple human dendritic cell (DC) subsets leads to enhanced T cell activation via IL-15-dependent DC crosstalk.
    Authors: Sehgal K, Ragheb R, Fahmy T, Dhodapkar M, Dhodapkar K
    J Immunol, 2014;193(5):2297-305.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  104. TRIM38 inhibits TNFalpha- and IL-1beta-triggered NF-kappaB activation by mediating lysosome-dependent degradation of TAB2/3.
    Authors: Hu M, Yang Q, Zhang J, Liu S, Zhang Y, Lin H, Huang Z, Wang Y, Zhang X, Zhong B, Shu H
    Proc Natl Acad Sci U S A, 2014;111(4):1509-14.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  105. Differentiation of IL-17-producing effector and regulatory human T cells from lineage-committed naive precursors.
    Authors: Mercer F, Khaitan A, Kozhaya L, Aberg J, Unutmaz D
    J Immunol, 2014;193(3):1047-54.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  106. Cyclic phosphatidic acid relieves osteoarthritis symptoms.
    Authors: Gotoh M, Nagano A, Tsukahara R, Murofushi H, Morohoshi T, Otsuka K, Murakami-Murofushi K
    Mol Pain, 2014;10(0):52.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  107. Interleukin 1/Toll-like receptor-induced autophosphorylation activates interleukin 1 receptor-associated kinase 4 and controls cytokine induction in a cell type-specific manner.
    Authors: Cushing L, Stochaj W, Siegel M, Czerwinski R, Dower K, Wright Q, Hirschfield M, Casanova J, Picard C, Puel A, Lin L, Rao V
    J Biol Chem, 2014;289(15):10865-75.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  108. Modulation of ten-eleven translocation 1 (TET1), Isocitrate Dehydrogenase (IDH) expression, alpha-Ketoglutarate (alpha-KG), and DNA hydroxymethylation levels by interleukin-1beta in primary human chondrocytes.
    Authors: Haseeb A, Makki M, Haqqi T
    J Biol Chem, 2014;289(10):6877-85.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  109. IL-32 promotes angiogenesis.
    Authors: Nold-Petry C, Rudloff I, Baumer Y, Ruvo M, Marasco D, Botti P, Farkas L, Cho S, Zepp J, Azam T, Dinkel H, Palmer B, Boisvert W, Cool C, Taraseviciene-Stewart L, Heinhuis B, Joosten L, Dinarello C, Voelkel N, Nold M
    J Immunol, 2014;192(2):589-602.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  110. A GPBAR1 (TGR5) small molecule agonist shows specific inhibitory effects on myeloid cell activation in vitro and reduces experimental autoimmune encephalitis (EAE) in vivo.
    Authors: Lewis, Nuruddee, Patnaude, Lori A, Pelletier, Josephin, Souza, Donald J, Lukas, Susan M, King, F James, Hill, Jonathan, Stefanopoulos, Dimitria, Ryan, Kelli, Desai, Sudha, Skow, Donna, Kauschke, Stefan G, Broermann, Andre, Kuzmich, Daniel, Harcken, Christia, Hickey, Eugene R, Modis, Louise K
    PLoS ONE, 2014;9(6):e100883.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  111. 1,25-Dihydroxyvitamin D3 and its analog TX527 promote a stable regulatory T cell phenotype in T cells from type 1 diabetes patients.
    Authors: Van Belle T, Vanherwegen A, Feyaerts D, De Clercq P, Verstuyf A, Korf H, Gysemans C, Mathieu C
    PLoS ONE, 2014;9(10):e109194.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  112. Langerhans cell maturation is accompanied by induction of N-cadherin and the transcriptional regulators of epithelial-mesenchymal transition ZEB1/2.
    Authors: Konradi S, Yasmin N, Haslwanter D, Weber M, Gesslbauer B, Sixt M, Strobl H
    Eur J Immunol, 2014;44(2):553-60.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  113. Interleukin-33 induces urokinase in human endothelial cells--possible impact on angiogenesis.
    Authors: Stojkovic S, Kaun C, Heinz M, Krychtiuk K, Rauscher S, Lemberger C, de Martin R, Groger M, Petzelbauer P, Huk I, Huber K, Wojta J, Demyanets S
    J Thromb Haemost, 2014;12(6):948-57.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  114. B7-H1-expressing antigen-presenting cells mediate polarization of protumorigenic Th22 subsets.
    Authors: Kuang D, Xiao X, Zhao Q, Chen M, Li X, Liu R, Wei Y, Ouyang F, Chen D, Wu Y, Lao X, Deng H, Zheng L
    J Clin Invest, 2014;124(10):4657-67.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  115. A central role for G9a and EZH2 in the epigenetic silencing of cyclooxygenase-2 in idiopathic pulmonary fibrosis.
    Authors: Coward W, Feghali-Bostwick C, Jenkins G, Knox A, Pang L
    FASEB J, 2014;28(7):3183-96.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  116. Enhanced expression of the central survival of motor neuron (SMN) protein during the pathogenesis of osteoarthritis.
    Authors: Cucchiarini M, Madry H, Terwilliger E
    J Cell Mol Med, 2014;18(1):115-24.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  117. Composition of innate lymphoid cell subsets in the human skin: enrichment of NCR(+) ILC3 in lesional skin and blood of psoriasis patients.
    Authors: Teunissen M, Munneke J, Bernink J, Spuls P, Res P, Te Velde A, Cheuk S, Brouwer M, Menting S, Eidsmo L, Spits H, Hazenberg M, Mjosberg J
    J Invest Dermatol, 2014;134(9):2351-60.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  118. TNF-alpha blockade induces IL-10 expression in human CD4+ T cells.
    Authors: Evans H, Roostalu U, Walter G, Gullick N, Frederiksen K, Roberts C, Sumner J, Baeten D, Gerwien J, Cope A, Geissmann F, Kirkham B, Taams L
    Nat Commun, 2014;5(0):3199.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  119. Vitamin D up-regulates the vitamin D receptor by protecting it from proteasomal degradation in human CD4+ T cells.
    Authors: Kongsbak M, von Essen M, Boding L, Levring T, Schjerling P, Lauritsen J, Woetmann A, Odum N, Bonefeld C, Geisler C
    PLoS ONE, 2014;9(5):e96695.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  120. A combined "omics" approach identifies N-Myc interactor as a novel cytokine-induced regulator of IRE1 protein and c-Jun N-terminal kinase in pancreatic beta cells.
    Authors: Brozzi F, Gerlo S, Grieco F, Nardelli T, Lievens S, Gysemans C, Marselli L, Marchetti P, Mathieu C, Tavernier J, Eizirik D
    J Biol Chem, 2014;289(30):20677-93.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  121. Roles for the mitogen-activated protein kinase (MAPK) phosphatase, DUSP1, in feedback control of inflammatory gene expression and repression by dexamethasone.
    Authors: Shah S, King E, Chandrasekhar A, Newton R
    J Biol Chem, 2014;289(19):13667-79.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  122. Nitric oxide enhances Th9 cell differentiation and airway inflammation.
    Authors: Niedbala W, Besnard A, Nascimento D, Donate P, Sonego F, Yip E, Guabiraba R, Chang H, Fukada S, Salmond R, Schmitt E, Bopp T, Ryffel B, Liew F
    Nat Commun, 2014;5(0):4575.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  123. BACH2, a candidate risk gene for type 1 diabetes, regulates apoptosis in pancreatic beta-cells via JNK1 modulation and crosstalk with the candidate gene PTPN2.
    Authors: Marroqui L, Santin I, Dos Santos R, Marselli L, Marchetti P, Eizirik D
    Diabetes, 2014;63(7):2516-27.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  124. The E3 deubiquitinase USP17 is a positive regulator of retinoic acid-related orphan nuclear receptor gammat (RORgammat) in Th17 cells.
    Authors: Han L, Yang J, Wang X, Wu Q, Yin S, Li Z, Zhang J, Xing Y, Chen Z, Tsun A, Li D, Piccioni M, Zhang Y, Guo Q, Jiang L, Bao L, Lv L, Li B
    J Biol Chem, 2014;289(37):25546-55.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  125. High activities of BACE1 in brains with mild cognitive impairment.
    Authors: Cheng X, He P, Lee T, Yao H, Li R, Shen Y
    Am J Pathol, 2014;184(1):141-7.
    Species: Human
    Sample Type: Whole Cells
    Application: cell culture
  126. Glucocorticoid-induced reversal of interleukin-1beta-stimulated inflammatory gene expression in human oviductal cells.
    Authors: Backman S, Kollara A, Haw R, Stein L, Brown T
    PLoS ONE, 2014;9(5):e97997.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  127. Self double-stranded (ds)DNA induces IL-1beta production from human monocytes by activating NLRP3 inflammasome in the presence of anti-dsDNA antibodies.
    Authors: Shin M, Kang Y, Lee N, Wahl E, Kim S, Kang K, Lazova R, Kang I
    J Immunol, 2013;190(4):1407-15.
    Species: Human
    Sample Type: Whole Cells
    Application: cell culture
  128. IL-1beta promotes antimicrobial immunity in macrophages by regulating TNFR signaling and caspase-3 activation.
    Authors: Jayaraman P, Sada-Ovalle I, Nishimura T, Anderson A, Kuchroo V, Remold H, Behar S
    J Immunol, 2013;190(8):4196-204.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  129. A mammalian pseudogene lncRNA at the interface of inflammation and anti-inflammatory therapeutics.
    Authors: Rapicavoli N, Qu K, Zhang J, Mikhail M, Laberge R, Chang H
    Elife, 2013;2(0):e00762.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  130. p53 controls autoimmune arthritis via STAT-mediated regulation of the Th17 cell/Treg cell balance in mice.
    Authors: Park J, Lim M, Cho M, Ryu J, Moon Y, Jhun J, Byun J, Kim E, Hwang S, Ju J, Kwok S, Kim H
    Arthritis Rheum, 2013;65(4):949-59.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  131. Targeting protein kinase CK2 suppresses prosurvival signaling pathways and growth of glioblastoma.
    Authors: Zheng Y, McFarland B, Drygin D, Yu H, Bellis S, Kim H, Bredel M, Benveniste E
    Clin Cancer Res, 2013;19(23):6484-94.
    Species: Human
    Sample Type: Whole Tissue
    Application: cell culture
  132. Cetuximab-activated natural killer and dendritic cells collaborate to trigger tumor antigen-specific T-cell immunity in head and neck cancer patients.
    Authors: Srivastava R, Lee S, Andrade Filho P, Lord C, Jie H, Davidson H, Lopez-Albaitero A, Gibson S, Gooding W, Ferrone S, Ferris R
    Clin Cancer Res, 2013;19(7):1858-72.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  133. Ginkgo biloba extract individually inhibits JNK activation and induces c-Jun degradation in human chondrocytes: potential therapeutics for osteoarthritis.
    Authors: Ho L, Hung L, Liu F, Hou T, Lin L, Huang C, Lai J
    PLoS ONE, 2013;8(12):e82033.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  134. The microvesicle component of HIV-1 inocula modulates dendritic cell infection and maturation and enhances adhesion to and activation of T lymphocytes.
    Authors: Mercier S, Donaghy H, Botting R, Turville S, Harman A, Nasr N, Ji H, Kusebauch U, Mendoza L, Shteynberg D, Sandgren K, Simpson R, Moritz R, Cunningham A
    PLoS Pathog, 2013;9(10):e1003700.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  135. Independent and interdependent immunoregulatory effects of IL-27, IFN-beta, and IL-10 in the suppression of human Th17 cells and murine experimental autoimmune encephalomyelitis.
    Authors: Fitzgerald D, Fonseca-Kelly Z, Cullimore M, Safabakhsh P, Saris C, Zhang G, Rostami A
    J Immunol, 2013;190(7):3225-34.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  136. CD161 expression characterizes a subpopulation of human regulatory T cells that produces IL-17 in a STAT3-dependent manner.
    Authors: Afzali B, Mitchell P, Edozie F, Povoleri G, Dowson S, Demandt L, Walter G, Canavan J, Scotta C, Menon B, Chana P, Khamri W, Kordasti S, Heck S, Grimbacher B, Tree T, Cope A, Taams L, Lechler R, John S, Lombardi G
    Eur J Immunol, 2013;43(8):2043-54.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  137. A GM-CSF/IL-33 pathway facilitates allergic airway responses to sub-threshold house dust mite exposure.
    Authors: Llop-Guevara A, Chu D, Walker T, Goncharova S, Fattouh R, Silver J, Moore C, Xie J, O'Byrne P, Coyle A, Kolbeck R, Humbles A, Stampfli M, Jordana M
    PLoS ONE, 2013;9(2):e88714.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  138. IL-7 licenses activation of human liver intrasinusoidal mucosal-associated invariant T cells.
    Authors: Tang, Xin-Zi, Jo, Juandy, Tan, Anthony, Sandalova, Elena, Chia, Adeline, Tan, Kai Chah, Lee, Kang Hoe, Gehring, Adam J, De Libero, Gennaro, Bertoletti, Antonio
    J Immunol, 2013;190(7):3142-52.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  139. Unraveling the signaling pathways promoting fibrosis in Dupuytren's disease reveals TNF as a therapeutic target.
    Authors: Verjee L, Verhoekx J, Chan J, Krausgruber T, Nicolaidou V, Izadi D, Davidson D, Feldmann M, Midwood K, Nanchahal J
    Proc Natl Acad Sci U S A, 2013;110(10):E928-37.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  140. Gli1 deletion prevents Helicobacter-induced gastric metaplasia and expansion of myeloid cell subsets.
    Authors: El-Zaatari M, Kao J, Tessier A, Bai L, Hayes M, Fontaine C, Eaton K, Merchant J
    PLoS ONE, 2013;8(3):e58935.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  141. Kynurenine 3-monooxygenase mediates inhibition of Th17 differentiation via catabolism of endogenous aryl hydrocarbon receptor ligands.
    Authors: Stephens G, Wang Q, Swerdlow B, Bhat G, Kolbeck R, Fung M
    Eur J Immunol, 2013;43(7):1727-34.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  142. EpCAM modulates NF-kappaB signaling and interleukin-8 expression in breast cancer.
    Authors: Sankpal N, Fleming T, Gillanders W
    Mol Cancer Res, 2013;11(4):418-26.
  143. Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency.
    Authors: Boisson B, Laplantine E, Prando C, Giliani S, Israelsson E, Xu Z, Abhyankar A, Israel L, Trevejo-Nunez G, Bogunovic D, Cepika A, MacDuff D, Chrabieh M, Hubeau M, Bajolle F, Debre M, Mazzolari E, Vairo D, Agou F, Virgin H, Bossuyt X, Rambaud C, Facchetti F, Bonnet D, Quartier P, Fournet J, Pascual V, Chaussabel D, Notarangelo L, Puel A, Israel A, Casanova J, Picard C
    Nat Immunol, 2012;13(12):1178-86.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  144. Increased levels of inflammatory cytokines and endothelin-1 in alveolar macrophages from patients with chronic heart failure.
    Authors: Sikkeland LI, Dahl CP, Ueland T, Andreassen AK, Gude E, Edvardsen T, Holm T, Yndestad A, Gullestad L, Kongerud J, Aukrust P, ØIe E
    PLoS ONE, 2012;7(5):e36815.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  145. Mycobacterium tuberculosis infection and tissue factor expression in macrophages.
    Authors: Kothari H, Rao L, Vankayalapati R, Pendurthi U
    PLoS ONE, 2012;7(9):e45700.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  146. Laminin-411 Is a Vascular Ligand for MCAM and Facilitates TH17 Cell Entry into the CNS.
    Authors: Flanagan K, Fitzgerald K, Baker J
    PLoS ONE, 2012;7(7):e40443.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  147. Identification of Axl as a downstream effector of TGF-beta1 during Langerhans cell differentiation and epidermal homeostasis.
    J. Exp. Med., 2012;209(11):2033-47.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  148. The SDF-1α/CXCR4 Axis is Required for Proliferation and Maturation of Human Fetal Pancreatic Endocrine Progenitor Cells.
    Authors: Kayali AG, Lopez AD, Hao E, Hinton A, Hayek A, King CC
    PLoS ONE, 2012;7(6):e38721.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  149. Cross-presentation of tumour antigens by human induced pluripotent stem cell-derived CD141(+)XCR1+ dendritic cells.
    Gene Ther, 2012;19(10):1035-40.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  150. Pentraxin 3 (PTX3) expression in allergic asthmatic airways: role in airway smooth muscle migration and chemokine production.
    Authors: Zhang J, Shan L, Koussih L, Redhu NS, Halayko AJ, Chakir J, Gounni AS
    PLoS ONE, 2012;7(4):e34965.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  151. Generation of allo-restricted peptide-specific T cells using RNA-pulsed dendritic cells: A three phase experimental procedure.
    Authors: Wilde S, Geiger C, Milosevic S, Mosetter B, Eichenlaub S, Schendel D
    Oncoimmunology, 2012;1(2):129-140.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  152. Role of interleukin-32 in Helicobacter pylori-induced gastric inflammation.
    Authors: Sakitani K, Hirata Y, Hayakawa Y, Serizawa T, Nakata W, Takahashi R, Kinoshita H, Sakamoto K, Nakagawa H, Akanuma M, Yoshida H, Maeda S, Koike K
    Infect Immun, 2012;80(11):3795-803.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  153. Interleukin-1alpha controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33.
    J. Exp. Med., 2012;209(8):1505-17.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  154. Tumor Microenvironment Macrophage Inhibitory Factor Directs the Accumulation of Interleukin-17-producing Tumor-infiltrating Lymphocytes and Predicts Favorable Survival in Nasopharyngeal Carcinoma Patients.
    Authors: Li J, Mo H, Xiong G, Zhang L, He J, Huang Z, Liu Z, Chen Q, Du Z, Zheng L, Qian C, Zeng Y
    J Biol Chem, 2012;287(42):35484-95.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  155. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.
    Authors: Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, Sutherlin DP, Koeppen H, Merchant M, Neve R, Settleman J
    Nature, 2012;487(7408):505-9.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  156. Targeting of macrophage galactose-type C-type lectin (MGL) induces DC signaling and activation.
    Authors: Napoletano C, Zizzari IG, Rughetti A, Rahimi H, Irimura T, Clausen H, Wandall HH, Belleudi F, Bellati F, Pierelli L, Frati L, Nuti M
    Eur. J. Immunol., 2012;42(4):936-45.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  157. Focal increases of fetal macrophages in placentas from pregnancies with histological chorioamnionitis: potential role of fibroblast monocyte chemotactic protein-1.
    Authors: Toti P, Arcuri F, Tang Z, Schatz F, Zambrano E, Mor G, Niven-Fairchild T, Abrahams VM, Krikun G, Lockwood CJ, Guller S
    Am. J. Reprod. Immunol., 2011;65(5):470-9.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  158. Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation.
    Authors: Jones GW, Stumhofer JS, Foster T, Twohig JP, Hertzog P, Topley N, Williams AS, Hunter CA, Jenkins BJ, Wang EC, Jones SA
    FASEB J., 2011;25(1):409-19.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  159. Identification of IDO-positive and IDO-negative human dendritic cells after activation by various proinflammatory stimuli.
    Authors: Von Bubnoff D, Scheler M, Wilms H, Fimmers R, Bieber T
    J. Immunol., 2011;186(12):6701-9.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  160. XOMA 052, a potent, high-affinity monoclonal antibody for the treatment of IL-1beta-mediated diseases.
    Authors: Owyang AM, Issafras H, Corbin J, Ahluwalia K, Larsen P, Pongo E, Handa M, Horwitz AH, Roell MK, Haak-Frendscho M, Masat L
    MAbs, 2011;3(1):49-60.
    Species: Human
    Sample Type: Buffer
    Application: Binding Assay
  161. B cells as a therapeutic target for IFN-beta in relapsing-remitting multiple sclerosis.
    Authors: Ramgolam VS, Sha Y, Marcus KL, Choudhary N, Troiani L, Chopra M, Markovic-Plese S
    J. Immunol., 2011;186(0):4518.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  162. Bacterial lipoprotein TLR2 agonists broadly modulate endothelial function and coagulation pathways in vitro and in vivo.
    Authors: Shin HS, Xu F, Bagchi A, Herrup E, Wilhelmsen K
    J. Immunol., 2011;186(2):1119-30.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  163. IL-17C regulates the innate immune function of epithelial cells in an autocrine manner.
    Authors: Ramirez-Carrozzi V, Sambandam A, Luis E
    Nat. Immunol., 2011;12(12):1159-66.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  164. Cadherin-11 regulates fibroblast inflammation.
    Authors: Chang SK, Noss EH, Chen M, Gu Z, Townsend K, Grenha R, Leon L, Lee SY, Lee DM, Brenner MB
    Proc. Natl. Acad. Sci. U.S.A., 2011;108(20):8402-7.
  165. IL-1F5, -F6, -F8, and -F9: A Novel IL-1 Family Signaling System That Is Active in Psoriasis and Promotes Keratinocyte Antimicrobial Peptide Expression.
    Authors: Johnston A, Xing X, Guzman AM, Riblett M, Loyd CM, Ward NL, Wohn C, Prens EP, Wang F, Maier LE, Kang S, Voorhees JJ, Elder JT, Gudjonsson JE
    J. Immunol., 2011;186(4):2613-22.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  166. Effects of TLR agonists on maturation and function of 3-day dendritic cells from AML patients in complete remission.
    Authors: Beck B, Dorfel D, Lichtenegger FS, Geiger C, Lindner L, Merk M, Schendel DJ, Subklewe M
    J Transl Med, 2011;9(0):151.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  167. Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency.
    Authors: Sancho-Shimizu V, Perez de Diego R, Lorenzo L, Halwani R, Alangari A, Israelsson E, Fabrega S, Cardon A, Maluenda J, Tatematsu M, Mahvelati F, Herman M, Ciancanelli M, Guo Y, AlSum Z, Alkhamis N, Al-Makadma AS, Ghadiri A, Boucherit S, Plancoulaine S, Picard C, Rozenberg F, Tardieu M, Lebon P, Jouanguy E, Rezaei N, Seya T, Matsumoto M, Chaussabel D, Puel A, Zhang SY, Abel L, Al-Muhsen S, Casanova JL
    J. Clin. Invest., 2011;121(12):4889-902.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  168. Cortisol Synthesis in Epidermis Is Induced by IL-1 and Tissue Injury.
    Authors: Vukelic S, Stojadinovic O, Pastar I, Rabach M, Krzyzanowska A, Lebrun E, Davis SC, Resnik S, Brem H, Tomic-Canic M
    J. Biol. Chem., 2011;286(12):10265-75.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  169. Direct inhibition of human RANK+ osteoclast precursors identifies a homeostatic function of IL-1beta.
    Authors: Lee B, Kim TH, Jun JB, Yoo DH, Woo JH, Choi SJ, Lee YH, Song GG, Sohn J, Park-Min KH, Ivashkiv LB, Ji JD
    J. Immunol., 2011;185(10):5926-34.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  170. A crucial role for Kupffer cell-derived galectin-9 in regulation of T cell immunity in hepatitis C infection.
    Authors: Mengshol JA, Golden-Mason L, Arikawa T
    PLoS ONE, 2010;5(3):e9504.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  171. Distinct roles of hepatocyte- and myeloid cell-derived IL-1 receptor antagonist during endotoxemia and sterile inflammation in mice.
    Authors: Lamacchia C, Palmer G, Bischoff L, Rodriguez E, Talabot-Ayer D, Gabay C
    J. Immunol., 2010;185(0):2516-24.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  172. Increased B7-H1 expression on dendritic cells correlates with programmed death 1 expression on T cells in simian immunodeficiency virus-infected macaques and may contribute to T cell dysfunction and disease progression.
    Authors: Xu H, Wang X, Pahar B
    J. Immunol., 2010;185(12):7340-8.
    Species: Primate - Macaca mulatta (Rhesus Macaque)
    Sample Type: Whole Cells
    Application: Bioassay
  173. Expression of interleukin 1-like cytokine interleukin 33 and its receptor complex (ST2L and IL1RAcP) in human pancreatic myofibroblasts.
    Authors: Nishida A, Andoh A, Imaeda H, Inatomi O, Shiomi H, Fujiyama Y
    Gut, 2010;59(4):531-41.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  174. Regulating human Th17 cells via differential expression of IL-1 receptor.
    Authors: Lee WW, Kang SW, Choi J
    Blood, 2010;115(3):530-40.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  175. Suppression of TNF-alpha and IL-1 signaling identifies a mechanism of homeostatic regulation of macrophages by IL-27.
    Authors: Kalliolias GD, Gordon RA, Ivashkiv LB
    J. Immunol., 2010;185(11):7047-56.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  176. Crucial role of interleukin-7 in T helper type 17 survival and expansion in autoimmune disease.
    Authors: Liu X, Leung S, Wang C, Tan Z, Wang J, Guo TB, Fang L, Zhao Y, Wan B, Qin X, Lu L, Li R, Pan H, Song M, Liu A, Hong J, Lu H, Zhang JZ
    Nat. Med., 2010;16(2):191-7.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  177. Interleukin-32 expression in the pancreas.
    Authors: Nishida A, Andoh A, Inatomi O, Fujiyama Y
    J. Biol. Chem., 2009;284(26):17868-76.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  178. CXCR3 activation by lentivirus infection suppresses neuronal autophagy: neuroprotective effects of antiretroviral therapy.
    Authors: Zhu Y, Vergote D, Pardo C, Noorbakhsh F, McArthur JC, Hollenberg MD, Overall CM, Power C
    FASEB J., 2009;23(9):2928-41.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  179. Human corneal epithelium-derived thymic stromal lymphopoietin links the innate and adaptive immune responses via TLRs and Th2 cytokines.
    Authors: Ma P, Bian F, Wang Z, Zheng X, Chotikavanich S, Pflugfelder SC, Li DQ
    Invest. Ophthalmol. Vis. Sci., 2009;50(6):2702-9.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  180. Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling.
    Authors: Boniface K, Bak-Jensen KS, Li Y, Blumenschein WM, McGeachy MJ, McClanahan TK, McKenzie BS, Kastelein RA, Cua DJ, de Waal Malefyt R
    J. Exp. Med., 2009;206(3):535-48.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  181. Ectopic expression of interleukin-1 receptor type II enhances cell migration through activation of the pre-interleukin 1alpha pathway.
    Authors: Chang SY, Su PF, Lee TC
    Cytokine, 2009;45(1):32-8.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  182. IL-17 in atopic eczema: linking allergen-specific adaptive and microbial-triggered innate immune response.
    Authors: Eyerich K, Pennino D, Scarponi C, Foerster S, Nasorri F, Behrendt H, Ring J, Traidl-Hoffmann C, Albanesi C, Cavani A
    J. Allergy Clin. Immunol., 2009;123(1):59-66.e4.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  183. Central opioid inhibition of neuroendocrine stress responses in pregnancy in the rat is induced by the neurosteroid allopregnanolone.
    Authors: Brunton PJ, McKay AJ, Ochedalski T, Piastowska A, Rebas E, Lachowicz A, Russell JA
    J. Neurosci., 2009;29(20):6449-60.
    Species: Rat
    Sample Type: In Vivo
    Application: In Vivo
  184. Interleukin-7 stimulates secretion of S100A4 by activating the JAK/STAT signaling pathway in human articular chondrocytes.
    Authors: Yammani RR, Long D, Loeser RF
    Arthritis Rheum., 2009;60(3):792-800.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  185. Proteinase-activated receptor (PAR)-2 activation impacts bone resorptive properties of human osteoarthritic subchondral bone osteoblasts.
    Authors: Amiable N, Tat SK, Lajeunesse D, Duval N, Pelletier JP, Martel-Pelletier J, Boileau C
    Bone, 2009;44(6):1143-50.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  186. Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells.
    Authors: Duhen T, Geiger R, Jarrossay D, Lanzavecchia A, Sallusto F
    Nat. Immunol., 2009;10(8):857-63.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  187. Interleukin-17 and interferon-gamma are produced concomitantly by human coronary artery-infiltrating T cells and act synergistically on vascular smooth muscle cells.
    Authors: Eid RE, Rao DA, Zhou J, Lo SF, Ranjbaran H, Gallo A, Sokol SI, Pfau S, Pober JS, Tellides G
    Circulation, 2009;119(10):1424-32.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  188. Evidence of a role for B cell-activating factor of the TNF family in the pathogenesis of chronic rhinosinusitis with nasal polyps.
    Authors: Kato A, Peters A, Suh L, Carter R, Harris KE, Chandra R, Conley D, Grammer LC, Kern R, Schleimer RP
    J. Allergy Clin. Immunol., 2008;121(6):1385-92, 1392.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  189. Endogenous IL-32 controls cytokine and HIV-1 production.
    Authors: Nold MF, Nold-Petry CA, Pott GB, Zepp JA, Saavedra MT, Kim SH, Dinarello CA
    J. Immunol., 2008;181(1):557-65.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  190. Maturing dendritic cells are an important source of IL-29 and IL-20 that may cooperatively increase the innate immunity of keratinocytes.
    Authors: Wolk K, Witte K, Witte E, Proesch S, Schulze-Tanzil G, Nasilowska K, Thilo J, Asadullah K, Sterry W, Volk HD, Sabat R
    J. Leukoc. Biol., 2008;83(5):1181-93.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  191. Guggulsterone blocks IL-1beta-mediated inflammatory responses by suppressing NF-kappaB activation in fibroblast-like synoviocytes.
    Authors: Lee YR, Lee JH, Noh EM, Kim EK, Song MY, Jung WS, Park SJ, Kim JS, Park JW, Kwon KB, Park BH
    Life Sci., 2008;82(23):1203-9.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  192. Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis.
    Authors: Stanczyk J, Pedrioli DM, Brentano F, Sanchez-Pernaute O, Kolling C, Gay RE, Detmar M, Gay S, Kyburz D
    Arthritis Rheum., 2008;58(4):1001-9.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  193. Upregulation of human cytomegalovirus by HIV type 1 in human lymphoid tissue ex vivo.
    Authors: Biancotto A, Iglehart SJ, Lisco A, Vanpouille C, Grivel JC, Lurain NS, Reichelderfer PS, Margolis LB
    AIDS Res. Hum. Retroviruses, 2008;24(3):453-62.
    Species: N/A
    Sample Type: N/A
    Application: ELISA Standard
  194. Cytokine mRNA induction by interleukin-1beta or tumor necrosis factor alpha in vitro and in vivo.
    Authors: Taishi P, Churchill L, De A, Obal F, Krueger JM
    Brain Res., 2008;1226(0):89-98.
    Species: Rat
    Sample Type: In Vivo
    Application: In Vivo
  195. Nitric oxide attenuates vascular endothelial cadherin-mediated vascular integrity in human chronic inflammation.
    Authors: Hama S, Takeichi O, Fujisaki K, Tanabe N, Maeno M, Ochiai K
    Clin. Exp. Immunol., 2008;154(3):384-90.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  196. Japanese Encephalitis Virus infection induces IL-18 and IL-1beta in microglia and astrocytes: correlation with in vitro cytokine responsiveness of glial cells and subsequent neuronal death.
    Authors: Das S, Mishra MK, Ghosh J, Basu A
    J. Neuroimmunol., 2008;195(1):60-72.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  197. Epigallocatechin-3-gallate inhibits IL-6 synthesis and suppresses transsignaling by enhancing soluble gp130 production.
    Authors: Ahmed S, Marotte H, Kwan K, Ruth JH, Campbell PL, Rabquer BJ, Pakozdi A, Koch AE
    Proc. Natl. Acad. Sci. U.S.A., 2008;105(38):14692-7.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  198. A novel IL-1 family cytokine, IL-33, potently activates human eosinophils.
    Authors: Cherry WB, Yoon J, Bartemes KR, Iijima K, Kita H
    J. Allergy Clin. Immunol., 2008;121(6):1484-90.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  199. Pre-eclampsia is associated with dendritic cell recruitment into the uterine decidua.
    Authors: Huang SJ, Chen CP, Schatz F, Rahman M, Abrahams VM, Lockwood CJ
    J. Pathol., 2008;214(3):328-36.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  200. A novel method to establish microglia-free astrocyte cultures: comparison of matrix metalloproteinase expression profiles in pure cultures of astrocytes and microglia.
    Authors: Crocker SJ, Frausto RF, Whitton JL, Milner R
    Glia, 2008;56(0):1187-98.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  201. IL-12-impaired and IL-12-secreting dendritic cells produce IL-23 upon CD154 restimulation.
    Authors: Jasny E, Eisenblatter M, Matz-Rensing K, Tenner-Racz K, Tenbusch M, Schrod A, Stahl-Hennig C, Moos V, Schneider T, Racz P, Uberla K, Kaup FJ, Ignatius R
    J. Immunol., 2008;180(10):6629-39.
    Species: Primate - Macaca mulatta (Rhesus Macaque)
    Sample Type: Whole Cells
    Application: Bioassay
  202. Bradykinin potentiates cytokine-induced prostaglandin biosynthesis in osteoblasts by enhanced expression of cyclooxygenase 2, resulting in increased RANKL expression.
    Authors: Brechter AB, Lerner UH
    Arthritis Rheum., 2007;56(3):910-23.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  203. Central role of the MEK/ERK MAP kinase pathway in a mouse model of rheumatoid arthritis: potential proinflammatory mechanisms.
    Authors: Thiel MJ, Schaefer CJ, Lesch ME, Mobley JL, Dudley DT, Tecle H, Barrett SD, Schrier DJ, Flory CM
    Arthritis Rheum., 2007;56(10):3347-57.
    Species: Rabbit
    Sample Type: In Vivo
    Application: In Vivo
  204. Interferon-gamma differentially regulates TGF-beta1 and TGF-beta2 expression in human retinal pigment epithelial cells through JAK-STAT pathway.
    Authors: Nagineni CN, Cherukuri KS, Kutty V, Detrick B, Hooks JJ
    J. Cell. Physiol., 2007;210(1):192-200.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  205. Crucial role of the protein C pathway in governing microvascular inflammation in inflammatory bowel disease.
    Authors: Scaldaferri F, Sans M, Vetrano S, Graziani C, De Cristofaro R, Gerlitz B, Repici A, Arena V, Malesci A, Panes J, Grinnell BW, Danese S
    J. Clin. Invest., 2007;117(7):1951-60.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  206. Expression and release of soluble HLA-E is an immunoregulatory feature of endothelial cell activation.
    Authors: Coupel S, Moreau A, Hamidou M, Horejsi V, Soulillou JP, Charreau B
    Blood, 2007;109(7):2806-14.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  207. Regulation of neuronal pituitary adenylate cyclase-activating polypeptide expression during culture of guinea-pig cardiac ganglia.
    Authors: Girard BM, Young BA, Buttolph TR, White SL, Parsons RL
    Neuroscience, 2007;146(2):584-93.
    Species: Guinea Pig
    Sample Type: Whole Cells
    Application: Bioassay
  208. Antiparallel segregation of notch components in the immunological synapse directs reciprocal signaling in allogeneic Th:DC conjugates.
    Authors: Luty WH, Rodeberg D, Parness J, Vyas YM
    J. Immunol., 2007;179(2):819-29.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  209. Substance P regulates macrophage inflammatory protein 3alpha/chemokine C-C ligand 20 (CCL20) with heme oxygenase-1 in human periodontal ligament cells.
    Authors: Lee SK, Pi SH, Kim SH, Min KS, Lee HJ, Chang HS, Kang KH, Kim HR, Shin HI, Lee SK, Kim EC
    Clin. Exp. Immunol., 2007;150(3):567-75.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  210. Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1.
    Authors: Biancotto A, Grivel JC, Iglehart SJ, Vanpouille C, Lisco A, Sieg SF, Debernardo R, Garate K, Rodriguez B, Margolis LB, Lederman MM
    Blood, 2007;109(10):4272-9.
    Species: N/A
    Sample Type: N/A
    Application: ELISA Standard
  211. The effects of IL-20 subfamily cytokines on reconstituted human epidermis suggest potential roles in cutaneous innate defense and pathogenic adaptive immunity in psoriasis.
    Authors: Sa SM, Valdez PA, Wu J
    J. Immunol., 2007;178(4):2229-40.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  212. IL-22 induces lipopolysaccharide-binding protein in hepatocytes: a potential systemic role of IL-22 in Crohn's disease.
    Authors: Wolk K, Witte E, Hoffmann U, Doecke WD, Endesfelder S, Asadullah K, Sterry W, Volk HD, Wittig BM, Sabat R
    J. Immunol., 2007;178(9):5973-81.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  213. IFN-gamma alters the response of Borrelia burgdorferi-activated endothelium to favor chronic inflammation.
    Authors: Dame TM, Orenzoff BL, Palmer LE, Furie MB
    J. Immunol., 2007;178(2):1172-9.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  214. Leukemia inhibitory factor functions as a growth factor in pancreas carcinoma cells: Involvement of regulation of LIF and its receptor expression.
    Authors: Kamohara H, Ogawa M, Ishiko T, Sakamoto K, Baba H
    Int. J. Oncol., 2007;30(4):977-83.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  215. Effect of serum content and diluent selection on assay sensitivity and signal intensity in multiplex bead-based immunoassays.
    Authors: Pfleger C, Schloot N, ter Veld F
    J. Immunol. Methods, 2007;329(1):214-8.
    Species: N/A
    Sample Type: N/A
    Application: ELISA Standard
  216. Ultrasensitive flow-based immunoassays using single-molecule counting.
    Authors: Todd J, Freese B, Lu A, Held D, Morey J, Livingston R, Goix P
    Clin. Chem., 2007;53(11):1990-5.
    Species: N/A
    Sample Type: N/A
    Application: ELISA Standard
  217. P2X receptor characterization and IL-1/IL-1Ra release from human endothelial cells.
    Authors: Wilson HL, Varcoe RW, Stokes L, Holland KL, Francis SE, Dower SK, Surprenant A, Crossman DC
    Br. J. Pharmacol., 2007;151(1):115-27.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  218. The immunomodulation of endotoxin-induced acute lung injury by hesperidin in vivo and in vitro.
    Authors: Yeh CC, Kao SJ, Lin CC, Wang SD, Liu CJ, Kao ST
    Life Sci., 2007;80(20):1821-31.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  219. Epithelial overexpression of interleukin-32alpha in inflammatory bowel disease.
    Authors: Shioya M, Nishida A, Yagi Y, Ogawa A, Tsujikawa T, Kim-Mitsuyama S, Takayanagi A, Shimizu N, Fujiyama Y, Andoh A
    Clin. Exp. Immunol., 2007;149(3):480-6.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  220. Dimethylfumarate specifically inhibits the mitogen and stress-activated kinases 1 and 2 (MSK1/2): possible role for its anti-psoriatic effect.
    Authors: Gesser B, Johansen C, Rasmussen MK, Funding AT, Otkjaer K, Kjellerup RB, Kragballe K, Iversen L
    J. Invest. Dermatol., 2007;127(9):2129-37.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  221. LIGHT up-regulated on B lymphocytes and monocytes in rheumatoid arthritis mediates cellular adhesion and metalloproteinase production by synoviocytes.
    Authors: Kang YM, Kim SY, Kang JH
    Arthritis Rheum., 2007;56(4):1106-17.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  222. Enhanced IL-1beta-induced IL-8 production in cystic fibrosis lung epithelial cells is dependent of both mitogen-activated protein kinases and NF-kappaB signaling.
    Authors: Muselet-Charlier C, Roque T, Boncoeur E, Chadelat K, Clement A, Jacquot J, Tabary O
    Biochem. Biophys. Res. Commun., 2007;357(2):402-7.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  223. Mitogen- and stress-activated protein kinase 2 and cyclic AMP response element binding protein are activated in lesional psoriatic epidermis.
    Authors: Funding AT, Johansen C, Kragballe K, Iversen L
    J. Invest. Dermatol., 2007;127(8):2012-9.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  224. Regulation of hepatocyte growth factor secretion by fibroblasts in patients with acute lung injury.
    Authors: Quesnel C, Marchand-Adam S, Fabre A, Marchal-Somme J, Philip I, Lasocki S, Lecon V, Crestani B, Dehoux M
    Am. J. Physiol. Lung Cell Mol. Physiol., 2007;294(2):L334-43.
    Species: Human
    Sample Type: BALF
    Application: Bioassay
  225. Interleukin 31 mediates MAP kinase and STAT1/3 activation in intestinal epithelial cells and its expression is upregulated in inflammatory bowel disease.
    Authors: Dambacher J, Beigel F, Seiderer J, Haller D, Goke B, Auernhammer CJ, Brand S
    Gut, 2007;56(9):1257-65.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  226. Constitutive and inducible thymic stromal lymphopoietin expression in human airway smooth muscle cells: role in chronic obstructive pulmonary disease.
    Authors: Zhang K, Shan L, Rahman MS, Unruh H, Halayko AJ, Gounni AS
    Am. J. Physiol. Lung Cell Mol. Physiol., 2007;293(2):L375-82.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  227. Inflammatory cytokines stimulate the adhesion of colon carcinoma cells to mesothelial monolayers.
    Authors: van Grevenstein WM, Hofland LJ, van Rossen ME, van Koetsveld PM, Jeekel J, van Eijck CH
    Dig. Dis. Sci., 2007;52(10):2775-83.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  228. Multiple NF-kappaB and IFN regulatory factor family transcription factors regulate CCL19 gene expression in human monocyte-derived dendritic cells.
    Authors: Pietila TE, Veckman V, Lehtonen A, Lin R, Hiscott J, Julkunen I
    J. Immunol., 2007;178(1):253-61.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  229. Infusion of stably immature monocyte-derived dendritic cells plus CTLA4Ig modulates alloimmune reactivity in rhesus macaques.
    Authors: Zahorchak AF, Kean LS, Tokita D, Turnquist HR, Abe M, Finke J, Hamby K, Rigby MR, Larsen CP, Thomson AW
    Transplantation, 2007;84(2):196-206.
    Species: Primate - Macaca mulatta (Rhesus Macaque)
    Sample Type: Whole Cells
    Application: Bioassay
  230. HIV-1 pathogenesis differs in rectosigmoid and tonsillar tissues infected ex vivo with CCR5- and CXCR4-tropic HIV-1.
    Authors: Grivel JC, Elliott J, Lisco A, Biancotto A, Condack C, Shattock RJ, McGowan I, Margolis L, Anton P
    AIDS, 2007;21(10):1263-72.
    Species: N/A
    Sample Type: N/A
    Application: ELISA Standard
  231. Synergism of TNF and IL-1 in the induction of matrix metalloproteinase-3 in trabecular meshwork.
    Authors: Kelley MJ, Rose AY, Song K, Chen Y, Bradley JM, Rookhuizen D, Acott TS
    Invest. Ophthalmol. Vis. Sci., 2007;48(6):2634-43.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  232. Bone morphogenetic protein 7 is elevated in patients with chronic liver disease and exerts fibrogenic effects on human hepatic stellate cells.
    Authors: Tacke F, Gabele E, Bataille F, Schwabe RF, Hellerbrand C, Klebl F, Straub RH, Luedde T, Manns MP, Trautwein C, Brenner DA, Scholmerich J, Schnabl B
    Dig. Dis. Sci., 2007;52(12):3404-15.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  233. Clinical outcome following acute ischaemic stroke relates to both activation and autoregulatory inhibition of cytokine production.
    Authors: Emsley HC, Smith CJ, Gavin CM
    BMC Neurol, 2007;7(0):5.
    Species: N/A
    Sample Type: N/A
    Application: ELISA Standard
  234. Low concentration of interleukin-1beta induces FLICE-inhibitory protein-mediated beta-cell proliferation in human pancreatic islets.
    Authors: Maedler K, Schumann DM, Sauter N, Ellingsgaard H, Bosco D, Baertschiger R, Iwakura Y, Oberholzer J, Wollheim CB, Gauthier BR, Donath MY
    Diabetes, 2006;55(10):2713-22.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  235. IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis.
    Authors: Wolk K, Witte E, Wallace E, Docke WD, Kunz S, Asadullah K, Volk HD, Sterry W, Sabat R
    Eur. J. Immunol., 2006;36(5):1309-23.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  236. Oncostatin M induces angiogenesis and cartilage degradation in rheumatoid arthritis synovial tissue and human cartilage cocultures.
    Authors: Fearon U, Mullan R, Markham T, Connolly M, Sullivan S, Poole AR, FitzGerald O, Bresnihan B, Veale DJ
    Arthritis Rheum., 2006;54(10):3152-62.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  237. Kinin receptor expression during Staphylococcus aureus infection.
    Authors: Bengtson SH, Phagoo SB, Norrby-Teglund A, Pahlman L, Morgelin M, Zuraw BL, Leeb-Lundberg LM, Herwald H
    Blood, 2006;108(6):2055-63.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  238. Th2 cytokine response in Major Depressive Disorder patients before treatment.
    Authors: Pavon L, Kiryushko D, Novitskaya V, Sandoval-Lopez G, Eugenia Hernandez M, Soroka V, Klingelhofer J, Loria F, Estrada I, Lukanidin E, Berezin V, Perez M, Moreno J, Bock E, Avila U, Leff P, Anton B, Heinze G
    J. Neuroimmunol., 2006;172(1):156-65.
    Species: N/A
    Sample Type: N/A
    Application: ELISA Standard
  239. Preterm labor is induced by intraamniotic infusions of interleukin-1beta and tumor necrosis factor-alpha but not by interleukin-6 or interleukin-8 in a nonhuman primate model.
    Authors: Sadowsky DW, Adams KM, Gravett MG, Witkin SS, Novy MJ
    Am. J. Obstet. Gynecol., 2006;195(6):1578-89.
    Species: Primate - Macaca mulatta (Rhesus Macaque)
    Sample Type: In Vivo
    Application: In Vivo
  240. Combination therapy: Synergistic suppression of virus-induced chemokines in airway epithelial cells.
    Authors: Edwards MR, Johnson MW, Johnston SL
    Am. J. Respir. Cell Mol. Biol., 2006;34(5):616-24.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  241. Cigarette smoke synergistically enhances respiratory mucin induction by proinflammatory stimuli.
    Authors: Baginski TK, Dabbagh K, Satjawatcharaphong C, Swinney DC
    Am. J. Respir. Cell Mol. Biol., 2006;35(2):165-74.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  242. The new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytes.
    Authors: Magne D, Palmer G, Barton JL, Mezin F, Talabot-Ayer D, Bas S, Duffy T, Noger M, Guerne PA, Nicklin MJ, Gabay C
    Arthritis Res. Ther., 2006;8(3):R80.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  243. Development of an in vitro pancreatic tissue model to study regulation of islet neogenesis associated protein expression.
    Authors: Petropavlovskaia M, Makhlin J, Sampalis J, Rosenberg L
    J. Endocrinol., 2006;191(1):65-81.
    Species: Hamster
    Sample Type: Whole Cells
    Application: Bioassay
  244. Modulation of neonatal microbial recognition: TLR-mediated innate immune responses are specifically and differentially modulated by human milk.
    Authors: LeBouder E, Rey-Nores JE, Raby AC, Affolter M, Vidal K, Thornton CA, Labeta MO
    J. Immunol., 2006;176(6):3742-52.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  245. Oncostatin M enhances CCL21 expression by microvascular endothelial cells and increases the efficiency of dendritic cell trafficking to lymph nodes.
    Authors: Sugaya M, Fang L, Cardones AR, Kakinuma T, Jaber SH, Blauvelt A, Hwang ST
    J. Immunol., 2006;177(11):7665-72.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  246. Normalizing the bone marrow microenvironment with p38 inhibitor reduces multiple myeloma cell proliferation and adhesion and suppresses osteoclast formation.
    Authors: Nguyen AN, Stebbins EG, Henson M, O&amp;amp;apos;Young G, Choi SJ, Quon D, Damm D, Reddy M, Ma JY, Haghnazari E, Kapoun AM, Medicherla S, Protter A, Schreiner GF, Kurihara N, Anderson J, Roodman GD, Navas TA, Higgins LS
    Exp. Cell Res., 2006;312(10):1909-23.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  247. Changes in periodontal and rheumatological conditions after 2 years in patients with juvenile idiopathic arthritis.
    Authors: Miranda LA, Braga F, Fischer RG, Sztajnbok FR, Figueredo CM, Gustafsson A
    J. Periodontol., 2006;77(10):1695-700.
    Species: N/A
    Sample Type: N/A
    Application: ELISA Standard
  248. HIV-1-infected and/or immune activated macrophages regulate astrocyte SDF-1 production through IL-1beta.
    Authors: Peng H, Erdmann N, Whitney N, Dou H, Gorantla S, Gendelman HE, Ghorpade A, Zheng J
    Glia, 2006;54(6):619-29.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  249. A cyanobacterial LPS antagonist prevents endotoxin shock and blocks sustained TLR4 stimulation required for cytokine expression.
    Authors: Macagno A, Molteni M, Rinaldi A
    J. Exp. Med., 2006;203(6):1481-92.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  250. Regulation of SDF-1 (CXCL12) production by osteoblasts; a possible mechanism for stem cell homing.
    Authors: Jung Y, Wang J, Schneider A, Sun YX, Koh-Paige AJ, Osman NI, McCauley LK, Taichman RS
    Bone, 2006;38(4):497-508.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  251. Expression of PDGF and their receptors in human retinal pigment epithelial cells and fibroblasts: regulation by TGF-beta.
    Authors: Nagineni CN, Kutty V, Detrick B, Hooks JJ
    J. Cell. Physiol., 2005;203(1):35-43.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  252. TNFalpha increases the inflammatory response to vascular balloon injury without accelerating neointimal formation.
    Authors: Miller AM, McPhaden AR, Preston A, Wadsworth RM, Wainwright CL
    Atherosclerosis, 2005;179(1):51-9.
    Species: Rabbit
    Sample Type: Whole Tissue
    Application: Bioassay
  253. Modulation of GM-CSF release by enantiomers of beta-agonists in human airway smooth muscle.
    Authors: Ameredes BT, Calhoun WJ
    J. Allergy Clin. Immunol., 2005;116(1):65-72.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  254. Pre-interleukin-1alpha expression reduces cell growth and increases interleukin-6 production in SaOS-2 osteosarcoma cells: Differential inhibitory effect of interleukin-1 receptor antagonist (icIL-1Ra1).
    Authors: Palmer G, Trolliet S, Talabot-Ayer D, Mezin F, Magne D, Gabay C
    Cytokine, 2005;31(2):153-60.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  255. Effects of the active metabolite of leflunomide, A77 1726, on cytokine release and the MAPK signalling pathway in human rheumatoid arthritis synoviocytes.
    Authors: Vergne-Salle&lt;/LastName&gt;&lt;F P&lt;/Initial, Vergne-Salle P, Leger DY, Bertin P, Treves R, Beneytout JL, Liagre B
    Cytokine, 2005;31(5):335-48.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  256. Interface tissue fibroblasts from loose total hip replacement prosthesis produce receptor activator of nuclear factor-kappaB ligand, osteoprotegerin, and cathepsin K.
    Authors: Mandelin J, Li TF, Hukkanen M, Liljestrom M, Salo J, Santavirta S, Konttinen YT
    J. Rheumatol., 2005;32(4):713-20.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  257. Phenotype and function of myeloid dendritic cells derived from African green monkey blood monocytes.
    Authors: Mortara L, Ploquin MJ, Faye A, Scott-Algara D, Vaslin B, Butor C, Hosmalin A, Barre-Sinoussi F, Diop OM, Muller-Trutwin MC
    J. Immunol. Methods, 2005;308(1):138-55.
    Species: Primate - Chlorocebus pygerythrus (Vervet Monkey)
    Sample Type: Whole Cells
  258. CYP7B expression and activity in fibroblast-like synoviocytes from patients with rheumatoid arthritis: regulation by proinflammatory cytokines.
    Authors: Dulos J, van der Vleuten MA, Kavelaars A, Heijnen CJ, Boots AM
    Arthritis Rheum., 2005;52(3):770-8.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  259. Interleukin-1beta induces CREB-binding protein (CBP) mRNA in brain and the sequencing of rat CBP.
    Authors: Tang C, Sula MJ, Bohnet S, Rehman A, Taishi P, Krueger JM
    Brain Res. Mol. Brain Res., 2005;137(1):213-22.
    Species: Rat
    Sample Type: In Vivo
    Application: In Vivo
  260. CC chemokines and transmigration of eosinophils in the presence of vascular cell adhesion molecule 1.
    Authors: Yamamoto H, Nagata M, Sakamoto Y
    Ann. Allergy Asthma Immunol., 2005;94(2):292-300.
    Species: Human
    Sample Type: Cell Culture Supernates
    Application: Bioassay
  261. Ultraviolet radiation-induced injury, chemokines, and leukocyte recruitment: An amplification cycle triggering cutaneous lupus erythematosus.
    Authors: Meller S, Winterberg F, Gilliet M, Muller A, Lauceviciute I, Rieker J, Neumann NJ, Kubitza R, Gombert M, Bunemann E, Wiesner U, Franken-Kunkel P, Kanzler H, Dieu-Nosjean MC, Amara A, Ruzicka T, Lehmann P, Zlotnik A, Homey B
    Arthritis Rheum., 2005;52(5):1504-16.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  262. A soluble form of the triggering receptor expressed on myeloid cells-1 modulates the inflammatory response in murine sepsis.
    Authors: Gibot S, Kolopp-Sarda MN, Bollaert PE, Lozniewski A, Mory F, Levy B, Faure GC
    J. Exp. Med., 2004;200(11):1419-26.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  263. Interferon-gamma inhibits transforming growth factor-beta production in human airway epithelial cells by targeting Smads.
    Authors: Wen FQ, Liu X, Kobayashi T, Abe S, Fang Q, Kohyama T, Ertl R, Terasaki Y, Manouilova L, Rennard SI
    Am. J. Respir. Cell Mol. Biol., 2004;30(6):816-22.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  264. Induction of lysosomal and plasma membrane-bound sialidases in human T-cells via T-cell receptor.
    Authors: Wang P, Zhang J, Bian H, Wu P, Kuvelkar R, Kung TT, Crawley Y, Egan RW, Billah MM
    Biochem. J., 2004;380(0):425-33.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  265. trans fatty acids and systemic inflammation in heart failure.
    Authors: Mozaffarian D, Rimm EB, King IB, Lawler RL, McDonald GB, Levy WC
    Am. J. Clin. Nutr., 2004;80(6):1521-5.
    Species: N/A
    Sample Type: N/A
    Application: ELISA Standard
  266. Rapid chemokine secretion from endothelial cells originates from 2 distinct compartments.
    Authors: Oynebraten I, Bakke O, Brandtzaeg P, Johansen FE, Haraldsen G
    Blood, 2004;104(2):314-20.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  267. IL-17 markedly up-regulates beta-defensin-2 expression in human airway epithelium via JAK and NF-kappaB signaling pathways.
    Authors: Kao CY, Chen Y, Thai P, Wachi S, Huang F, Kim C, Harper RW, Wu R
    J. Immunol., 2004;173(5):3482-91.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  268. Direct comparison of traditional ELISAs and membrane protein arrays for detection and quantification of human cytokines.
    Authors: Copeland S, Siddiqui J, Remick D
    J. Immunol. Methods, 2004;284(1):99-106.
    Species: N/A
    Sample Type: N/A
    Application: ELISA Standard
  269. CD14 is an acute-phase protein.
    Authors: Bas S, Gauthier BR, Spenato U, Stingelin S, Gabay C
    J. Immunol., 2004;172(7):4470-9.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  270. Distinct roles of IL-12 and IL-15 in human natural killer cell activation by dendritic cells from secondary lymphoid organs.
    Authors: Ferlazzo G, Pack M, Thomas D, Paludan C, Schmid D, Strowig T, Bougras G, Muller WA, Moretta L, Munz C
    Proc. Natl. Acad. Sci. U.S.A., 2004;101(47):16606-11.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  271. Rapid analysis of inflammatory cytokines in cerebrospinal fluid using chip-based immunoaffinity electrophoresis.
    Authors: Phillips TM
    Electrophoresis, 2004;25(10):1652-9.
    Species: N/A
    Sample Type: N/A
    Application: Standard
  272. Interleukin-1 inhibits voltage-dependent P/Q-type Ca2+ channel associated with the inhibition of the rise of intracellular free Ca2+ concentration and catecholamine release in adrenal chromaffin cells.
    Authors: Morita K, Miyasako T, Kitayama S, Dohi T
    Biochim. Biophys. Acta, 2004;1673(3):160-9.
    Species: Bovine
    Sample Type: Whole Cells
    Application: Bioassay
  273. Chondrocyte response to growth factors is modulated by p38 mitogen-activated protein kinase inhibition.
    Authors: Studer RK, Bergman R, Stubbs T, Decker K
    Arthritis Res. Ther., 2004;6(1):R56-R64.
    Species: Rabbit
    Sample Type: Whole Cells
    Application: Bioassay
  274. Proline-rich tyrosine kinase 2 and Src kinase signaling transduce monosodium urate crystal-induced nitric oxide production and matrix metalloproteinase 3 expression in chondrocytes.
    Authors: Liu R, Liote F, Rose DM, Merz D, Terkeltaub R
    Arthritis Rheum., 2004;50(1):247-58.
    Species: Bovine
    Sample Type: Whole Cells
    Application: Bioassay
  275. Lack of phenotypic and functional impairment in dendritic cells from chimpanzees chronically infected with hepatitis C virus.
    Authors: Larsson M, Babcock E, Grakoui A, Shoukry N, Lauer G, Rice C, Walker C, Bhardwaj N
    J. Virol., 2004;78(12):6151-61.
    Species: Primate - Pan troglodytes (Chimpanzee)
    Sample Type: Whole Cells
    Application: Bioassay
  276. A soluble form of the triggering receptor expressed on myeloid cells-1 modulates the inflammatory response in murine sepsis.
    Authors: Gibot S, Kolopp-Sarda MN, Bollaert PE, Lozniewski A, Mory F, Levy B, Faure GC
    J. Exp. Med., 2004;200(11):1419-26.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  277. CC chemokine ligand 18, an atopic dermatitis-associated and dendritic cell-derived chemokine, is regulated by staphylococcal products and allergen exposure.
    Authors: Pivarcsi A, Gombert M, Dieu-Nosjean MC, Kubitza R, Meller S, Rieker J, Muller A, Da Cunha L, Haahtela A, Sonkoly E, Fridman WH, Alenius H, Kemeny L, Ruzicka T, Zlotnik A
    J. Immunol., 2004;173(9):5810-7.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  278. Expression of Fas but not Fas ligand on fetal pig beta cells.
    Authors: Bai L, Maedler K, Donath M, Tuch BE
    Xenotransplantation, 2004;11(5):426-35.
    Species: Porcine
    Sample Type: Whole Cells
    Application: Bioassay
  279. The soluble form of IL-1 receptor accessory protein enhances the ability of soluble type II IL-1 receptor to inhibit IL-1 action.
    Authors: Smith DE, Hanna R, Della Friend, Moore H, Chen H, Farese AM, MacVittie TJ, Virca GD, Sims JE
    Immunity, 2003;18(1):87-96.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  280. Interleukin-8 production in tuberculous pleurisy: role of mesothelial cells stimulated by cytokine network involving tumour necrosis factor-alpha and interleukin-1 beta.
    Authors: Park JS, Kim YS, Jee YK, Myong NH, Lee KY
    Scand. J. Immunol., 2003;57(5):463-9.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  281. Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation.
    Authors: McLoughlin RM, Witowski J, Robson RL, Wilkinson TS, Hurst SM, Williams AS, Williams JD, Rose-John S, Jones SA, Topley N
    J. Clin. Invest., 2003;112(4):598-607.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  282. ING-1(heMAb), a monoclonal antibody to epithelial cell adhesion molecule, inhibits tumor metastases in a murine cancer model.
    Authors: Ruan HH, Scott KR, Bautista E, Ammons WS
    Neoplasia, 2003;5(6):489-94.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  283. Alteration of locus coeruleus neuronal activity by interleukin-1 and the involvement of endogenous corticotropin-releasing hormone.
    Authors: Borsody MK, Weiss JM
    Neuroimmunomodulation, 2002;10(2):101-21.
    Species: Rat
    Sample Type: In Vivo
    Application: In Vivo
  284. Tumour necrosis factor-alpha- and interleukin-1beta-stimulated cell proliferation through activation of mitogen-activated protein kinase in canine tracheal smooth muscle cells.
    Authors: Yang CM, Luo SF, Wang CC, Chiu CT, Chien CS, Lin CC, Hsiao LD
    Br. J. Pharmacol., 2000;130(4):891-9.
    Species: Canine
    Sample Type: Whole Cells
    Application: Bioassay
  285. Gingival crevicular fluid from patients with periodontitis contains bone resorbing activity.
    Authors: Lerner UH, Modeer T, Krekmanova L, Claesson R, Rasmussen L
    Eur. J. Oral Sci., 1998;106(3):778-87.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  286. Measurement of interleukin-33 (IL-33) and IL-33 receptors (sST2 and ST2L) in patients with rheumatoid arthritis.
    Authors: Hong YS, Moon S, Moon SJ, Joo YB, Joo Y, Jeon C, Jeon CH, Cho ML, Ju JH, Oh HJ, Heo YJ, Heo Y, Park SH, Kim HY, Min JK
    J Korean Med Sci, 0;26(9):1132-9.
  287. TGF-beta Affects the Differentiation of Human GM-CSF+ CD4+ T Cells in an Activation- and Sodium-Dependent Manner.
    Authors: Elias S, Schmidt A, Kannan V, Andersson J, Tegner J
    Front Immunol, 0;7(0):603.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  288. 4-Methylumbelliferone Diminishes Catabolically Activated Articular Chondrocytes and Cartilage Explants via a Mechanism Independent of Hyaluronan Inhibition.
    Authors: Ishizuka S, Askew E, Ishizuka N, Knudson C, Knudson W
    J Biol Chem, 0;291(23):12087-104.
  289. Biglycan, a danger signal that activates the NLRP3 inflammasome via toll-like and P2X receptors.
    Authors: Babelova A, Moreth K, Tsalastra-Greul W, Zeng-Brouwers J, Eickelberg O, Young MF, Bruckner P, Pfeilschifter J, Schaefer RM, Schaefer R, Grone HJ, Schaefer L
    J Biol Chem, 0;284(36):24035-48.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
Expand to show all 289 Citations
Animal-Free Recombinant Proteins
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Recombinant Human IL-1 beta/IL-1F2, Animal-Free Protein

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