Recombinant Human Noggin Protein

GMP Version Available: 6057-GMP
GMP

Carrier Free

Catalog # Availability Size / Price Qty
6057-NG-025/CF
6057-NG-100/CF
6057-NG-01M/CF

With Carrier

Catalog # Availability Size / Price Qty
6057-NG-025
6057-NG-100
6057-NG-01M
Superior and Consistent Pluripotent Stem Cell Differentiation with R&D Systems Recombinant Human Noggin.
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Product Details
Citations (171)
FAQs
Supplemental Products
Reviews (8)

Recombinant Human Noggin Protein Summary

Product Specifications

Purity
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Level
<0.10 EU per 1 μg of the protein by the LAL method.
Activity
Measured by its ability to inhibit BMP-4-induced alkaline phosphatase production by ATDC5 mouse chondrogenic cells. The ED50 for this effect is 0.02-0.16 μg/mL in the presence of 50 ng/mL of Recombinant Human BMP‑4 (Catalog # 314-BP).
Source
Mouse myeloma cell line, NS0-derived human Noggin protein
Gln28-Cys232
Accession #
N-terminal Sequence
Analysis
No results obtained: Gln28 predicted
Structure / Form
Disulfide-linked homodimer
Predicted Molecular Mass
23 kDa (monomer)
SDS-PAGE
30-33 kDa, reducing conditions

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6057-NG (with carrier)

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6057-NG/CF (carrier free)

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

6057-NG

Formulation Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Reconstitution Reconstitute at 250 μg/mL in PBS  containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

6057-NG/CF

Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution Reconstitute at 250 μg/mL in PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Scientific Data

Bioactivity Superior and Consistent Pluripotent Stem Cell Differentiation with R&D Systems Recombinant Human Noggin. View Larger

BG01V human embryonic stem cells were cultured in Mouse Embryonic Fibroblast Conditioned Media supplemented with FGF basic (5 ng/mL). Stem cells were driven into early cells of the neuroectoderm using a 3 day incubation in recombinant human Noggin (25 µg/mL) from either R&D Systems (Lot 1, Lot 2; Catalog # 6057-NG) or from two separate competitors (Competitor 1, Competitor 2). Control cells were not incubated in Noggin (No Noggin). The cells were stained for the early ectoderm marker, Otx2, and the neuroectoderm marker, SOX1. (A) Representative images of SOX1 (green), Otx2 (red), and DAPI (blue) staining in embryonic stem cells differentiated with Noggin from R&D Systems or Noggin from Competitor 2. (B) SOX1+ clusters were quantified under each of the indicated culture conditions. Cells treated with R&D Systems Noggin showed an increase in SOX1+ cells compared to both untreated and competitor-treated cells. R&D Systems Noggin showed consistent differentiation across the lots tested. BG01V human embryonic stem cells are licensed from ViaCyte, Inc.

Bioactivity Superior and Consistent Pluripotent Stem Cell Differentiation with R&D Systems Recombinant Human Noggin. View Larger

Recombinant Human Noggin (Catalog # 6057-NG) inhibits BMP-4 induced alkaline phosphatase production in the ATDC5 mouse chondrogenic cell line. The activity is approximately 30-fold greater than the top competitor's Noggin.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: Noggin

Noggin is a secreted homodimeric glycoprotein that is an antagonist of bone morphogenetic proteins (BMPs) (1, 2). Human Noggin cDNA encodes a 232 amino acid (aa) precursor protein; cleavage of a 19 aa signal peptide generates the 213 aa mature protein which contains an N-terminal acidic region, a central basic heparin‑binding segment and a C-terminal cysteine-knot structure (2). Secreted Noggin probably remains close to the cell surface due to its binding of heparin‑containing proteoglycans (3). Noggin is very highly conserved among vertebrates, such that mature human Noggin shares 99%, 99%, 98%, 97% and 89% aa sequence identity with mouse, rat, bovine, equine and chicken Noggin, respectively. Noggin binds some BMPs such as BMP-4 with high affinity and others such as BMP-7 with lower affinity. It antagonizes BMP bioactivities by blocking epitopes on BMPs that are needed for binding to both type I and type II receptors (2, 4). During embryogenesis, Noggin antagonizes specific BMPs at defined times, for example, during neural tube, somite and cardiomyocyte growth and patterning (5-7). During skeletal development, Noggin prevents chondrocyte hyperplasia, thus allowing proper formation of joints (4). Mutations within the cysteine-knot region of human Noggin are linked to multiple types of skeletal dysplasias that result in apical joint fusions (8). Noggin is expressed in defined areas of the adult central nervous system and peripheral tissues such as lung, skeletal muscle and skin (1). During culture of human embryonic stem cells (hESC) or neural stem cells under certain conditions, addition of Noggin to antagonize BMP activity may allow stem cells to proliferate while maintaining their undifferentiated state, or alternatively, to differentiate into dopaminergic neurons (6, 9 - 13). Noggin also appears to maintain adult stem cell populations in-vivo, for example, maintaining neural stem cells within the hippocampus (13).

References
  1. Valenzuela, D.M. et al. (1995) J. Neurosci. 15:6077.
  2. Groppe, J. et al. (2002) Nature 420:636.
  3. Paine-Saunders, S et al. (2002) J. Biol. Chem. 277:2089.
  4. Brunet, L. J. et al. (1998) Science 280:1455.
  5. McMahon, J. A. et al. (1998) Genes Dev. 12:1438.
  6. Itsykson, P. et al. (2005) Mol. Cell. Neurosci. 30:24.
  7. Yuasa, S. et al. (2005) Nat. Biotechnol. 23:607.
  8. Gong, Y. et al. (1999) Nat. Genet. 21:302.
  9. Xu, R.-H. et al. (2005) Nat. Methods 2:185.
  10. Wang, G. et al. (2005) Biochem. Biophys. Res. Commun. 330:934.
  11. Chaturvedi, G. et al. (2009) Cell Prolif. 42:425.
  12. Chiba, S. et al. (2008) Stem Cells 26:2810.
  13. Bonaguidi, M.A. et al. (2008) J. Neurosci. 28:9194.
Entrez Gene IDs
9241 (Human); 18121 (Mouse)
Alternate Names
NOG; Noggin; SYM1; symphalangism 1 (proximal); synostoses (multiple) syndrome 1; SYNS1; SYNS1A

Citations for Recombinant Human Noggin Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

171 Citations: Showing 1 - 10
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  1. Early Signs of Molecular Defects in iPSC-Derived Neural Stems Cells from Patients with Familial Parkinson's Disease
    Authors: E Akrioti, T Karamitros, P Gkaravelas, G Kouroupi, R Matsas, E Taoufik
    Biomolecules, 2022;12(7):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  2. Pterostilbene in Combination With Mitochondrial Cofactors Improve Mitochondrial Function in Cellular Models of Mitochondrial Diseases
    Authors: JM Suárez-Riv, CJ Pastor-Mal, A Romero-Gon, D Gómez-Fern, S Povea-Cabe, M Álvarez-Có, I Villalón-G, M Talaverón-, A Suárez-Car, M Munuera-Ca, JA Sánchez-Al
    Frontiers in Pharmacology, 2022;13(0):862085.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  3. OncoSNIPE� Study Protocol, a study of molecular profiles associated with development of resistance in solid cancer patients
    Authors: S Vachenc, J Gobbo, SE Moujarrebe, I Desmoulins, M Gilabert, M Beau-Falle, E Mitry, N Girard, A Bertaut, N Dusetti, JL Iovanna, R Yousfi, F Pierrat, R Bruno, A Cueff, R Boidot, P Genne
    BMC Cancer, 2022;22(1):41.
    Species: Human
    Sample Types: Organoid
    Applications: Bioassay
  4. ATG7-mediated autophagy facilitates embryonic stem cell exit from naive pluripotency and marks commitment to differentiation
    Authors: J Zhou, H He, JJ Zhang, X Liu, W Yao, C Li, T Xu, SY Yin, DY Wu, CL Dou, Q Li, J Xiang, WJ Xiong, LY Wang, JM Tang, Z Xue, X Zhang, YL Miao
    Autophagy, 2022;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  5. Epithelial-derived factors induce muscularis mucosa of human induced pluripotent stem cell-derived gastric organoids
    Authors: K Uehara, M Koyanagi-A, T Koide, T Itoh, T Aoi
    Stem Cell Reports, 2022;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  6. Tissue extracellular matrix hydrogels as alternatives to Matrigel for culturing gastrointestinal organoids
    Authors: S Kim, S Min, YS Choi, SH Jo, JH Jung, K Han, J Kim, S An, YW Ji, YG Kim, SW Cho
    Nature Communications, 2022;13(1):1692.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  7. Modeling Pancreatic Cancer with Patient-Derived Organoids Integrating Cancer-Associated Fibroblasts
    Authors: YH Go, WH Choi, WJ Bae, SI Jung, CH Cho, SA Lee, JS Park, JM Ahn, SW Kim, KJ Lee, D Lee, J Yoo
    Cancers, 2022;14(9):.
    Species: Human
    Sample Types: Organoids
    Applications: Bioassay
  8. Patient-derived micro-organospheres enable clinical precision oncology
    Authors: S Ding, C Hsu, Z Wang, NR Natesh, R Millen, M Negrete, N Giroux, GO Rivera, A Dohlman, S Bose, T Rotstein, K Spiller, A Yeung, Z Sun, C Jiang, R Xi, B Wilkin, PM Randon, I Williamson, DA Nelson, D Delubac, S Oh, G Rupprecht, J Isaacs, J Jia, C Chen, JP Shen, S Kopetz, S McCall, A Smith, N Gjorevski, AC Walz, S Antonia, E Marrer-Ber, H Clevers, D Hsu, X Shen
    Cell Stem Cell, 2022;0(0):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: Bioassay
  9. Delamination of trophoblast-like syncytia from the amniotic ectodermal analogue in human primed embryonic stem cell-based differentiation model
    Authors: M Ohgushi, N Taniyama, A Vandenbon, M Eiraku
    Cell Reports, 2022;39(12):110973.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  10. Equine Oviductal Organoid Generation and Cryopreservation
    Authors: RE Thompson, MA Meyers, DNR Veeramacha, BS Pukazhenth, FK Hollinshea
    Methods and protocols, 2022;5(3):.
    Species: Equine
    Sample Types: Organoid
    Applications: Bioassay
  11. Directed differentiation of human pluripotent stem cells into diverse organ-specific mesenchyme of the digestive and respiratory systems
    Authors: K Kishimoto, K Iwasawa, A Sorel, C Ferran-Her, L Han, M Morimoto, JM Wells, T Takebe, AM Zorn
    Nature Protocols, 2022;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  12. Quantitative analysis of transcriptome dynamics provides novel insights into developmental state transitions
    Authors: K Johnson, S Freedman, R Braun, C LaBonne
    BMC Genomics, 2022;23(1):723.
    Species: Frog
    Sample Types:
    Applications: Bioassay
  13. Antibody targeting of E3 ubiquitin ligases for receptor degradation
    Authors: H Marei, WK Tsai, YS Kee, K Ruiz, J He, C Cox, T Sun, S Penikalapa, P Dwivedi, M Choi, D Kan, P Saenz-Lope, K Dorighi, P Zhang, YT Kschonsak, N Kljavin, D Amin, I Kim, AG Mancini, T Nguyen, C Wang, E Janezic, A Doan, E Mai, H Xi, C Gu, M Heinlein, B Biehs, J Wu, I Lehoux, S Harris, L Comps-Agra, D Seshasayee, FJ de Sauvage, M Grimmer, J Li, NJ Agard, F de Sousa E
    Nature, 2022;610(7930):182-189.
    Species: Human
    Sample Types: Organoid
    Applications: Bioassay
  14. Fluvastatin promotes chondrogenic differentiation of adipose-derived mesenchymal stem cells by inducing bone morphogenetic protein 2
    Authors: M Kuwahara, Y Akasaki, N Goto, I Kurakazu, T Sueishi, M Toya, T Uchida, T Tsutsui, R Hirose, H Tsushima, Y Nakashima
    Bmc Pharmacology & Toxicology, 2022;23(1):61.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  15. Sox2 in the dermal papilla regulates hair follicle pigmentation
    Authors: KJ Ng, J Lim, YN Tan, D Quek, Z Lim, N Pantelirei, C Clavel
    Oncogene, 2022;40(3):111100.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  16. Intracameral Microimaging of Maturation of Human iPSC Derivatives into Islet Endocrine Cells
    Authors: K Zhao, Y Shi, J Yu, L Yu, A Mael, Y Li, A Kolton, T Joyce, J Odorico, PO Berggren, SN Yang
    Cell Transplantation, 2022;31(0):9636897211066.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  17. Novel chicken two-dimensional intestinal model comprising all key epithelial cell types and a mesenchymal sub-layer
    Authors: B Orr, K Sutton, S Christian, T Nash, H Niemann, LL Hansen, MJ McGrew, SR Jensen, L Vervelde
    Veterinary research, 2021;52(1):142.
    Species: Chicken
    Sample Types: Whole Cells
    Applications: Bioassay
  18. Epithelial phenotype restoring drugs suppress macular degeneration phenotypes in an iPSC model
    Authors: R Sharma, A George, M Nimmagadda, D Ortolan, BS Karla, Z Qureshy, D Bose, R Dejene, G Liang, Q Wan, J Chang, BS Jha, O Memon, KJ Miyagishim, A Rising, M Lal, E Hanson, R King, MM Campos, M Ferrer, J Amaral, D McGaughey, K Bharti
    Nature Communications, 2021;12(1):7293.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  19. Human iPSC-derived fallopian tube organoids with BRCA1 mutation recapitulate early-stage carcinogenesis
    Authors: N Yucer, R Ahdoot, MJ Workman, AH Laperle, MS Recouvreux, K Kurowski, DJ Naboulsi, V Liang, Y Qu, JT Plummer, SA Gayther, S Orsulic, BY Karlan, CN Svendsen
    Cell Reports, 2021;37(13):110146.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  20. APOE2 mitigates disease-related phenotypes in an isogenic hiPSC-based model of Alzheimer's disease
    Authors: N Brookhouse, S Raman, C Frisch, G Srinivasan, DA Brafman
    Molecular Psychiatry, 2021;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  21. A quantitative model of cellular decision making in direct neuronal reprogramming
    Authors: A Merlevede, EM Legault, V Drugge, RA Barker, J Drouin-Oue, V Olariu
    Scientific Reports, 2021;11(1):1514.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  22. Pluripotent stem cell-derived corneal endothelial cells as an alternative to donor corneal endothelium in keratoplasty
    Authors: M Ali, SY Khan, JD Gottsch, EK Hutchinson, A Khan, SA Riazuddin
    Stem Cell Reports, 2021;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  23. Exploring the Complementarity of Pancreatic Ductal Adenocarcinoma Preclinical Models
    Authors: O Hoare, N Fraunhoffe, A Elkaoutari, O Gayet, M Bigonnet, J Roques, R Nicolle, C McGuckin, N Forraz, E Sohier, L Tonon, P Wajda, S Boyault, V Attignon, S Tabone-Egl, S Barbier, C Mignard, O Duchamp, J Iovanna, NJ Dusetti
    Cancers, 2021;13(10):.
    Species: Human
    Sample Types: Organoid
    Applications: Bioassay
  24. Establishment of human induced trophoblast stem-like cells from term villous cytotrophoblasts
    Authors: T Bai, CY Peng, I Aneas, N Sakabe, DF Requena, C Billstrand, M Nobrega, C Ober, M Parast, JA Kessler
    Stem Cell Research, 2021;56(0):102507.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  25. Measuring the elastic modulus of soft culture surfaces and three-dimensional hydrogels using atomic force microscopy
    Authors: MDA Norman, SA Ferreira, GM Jowett, L Bozec, E Gentleman
    Nature Protocols, 2021;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  26. Functional human gastrointestinal organoids can be engineered from three primary germ layers derived separately from pluripotent stem cells
    Authors: AK Eicher, DO Kechele, N Sundaram, HM Berns, HM Poling, LE Haines, JG Sanchez, K Kishimoto, M Krishnamur, L Han, AM Zorn, MA Helmrath, JM Wells
    Cell Stem Cell, 2021;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  27. Porcine small intestinal organoids as a model to explore ETEC-host interactions in the gut
    Authors: B Vermeire, LM Gonzalez, RJJ Jansens, E Cox, B Devriendt
    Veterinary research, 2021;52(1):94.
    Species: Porcine
    Sample Types: Organoids
    Applications: Bioassay
  28. Rational design and optimization of synthetic gene switches for controlling cell-fate decisions in pluripotent stem cells
    Authors: V Haellman, P Saxena, Y Jiang, M Fussenegge
    Metabolic engineering, 2021;65(0):99-110.
    Species: N/A
    Sample Types: Plasmid
    Applications: Bioassay
  29. Reprogramming Human Adult Fibroblasts into GABAergic Interneurons
    Authors: A Bruzelius, S Kidnapilla, J Drouin-Oue, T Stoker, RA Barker, D Rylander O
    Cells, 2021;10(12):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  30. Generation of equine enteroids and enteroid-derived 2D monolayers that are responsive to microbial mimics
    Authors: S Hellman
    Veterinary research, 2021;52(1):108.
    Species: Equine
    Sample Types: Organoid
    Applications: Bioassay
  31. Targeting uPA-uPAR interaction to improve intestinal epithelial barrier integrity in inflammatory bowel disease
    Authors: Y Cheng, TR Hall, X Xu, I Yung, D Souza, J Zheng, F Schiele, M Hoffmann, ML Mbow, JP Garnett, J Li
    EBioMedicine, 2021;75(0):103758.
    Species: Human
    Sample Types: Organoid
    Applications: Bioassay
  32. Local non-pituitary growth hormone is induced with aging and facilitates epithelial damage
    Authors: V Chesnokova, S Zonis, A Apostolou, HQ Estrada, S Knott, K Wawrowsky, K Michelsen, A Ben-Shlomo, R Barrett, V Gorbunova, K Karalis, S Melmed
    Cell Reports, 2021;37(11):110068.
    Species: Human
    Sample Types: Organoid
    Applications: Bioassay
  33. Relevance of biopsy-derived pancreatic organoids in the development of efficient transcriptomic signatures to predict adjuvant chemosensitivity in pancreatic cancer
    Authors: R Nicolle, O Gayet, M Bigonnet, J Roques, B Chanez, F Puleo, J Augustin, JF Emile, M Svrcek, T Arsenijevi, P Hammel, V Rebours, M Giovannini, P Grandval, L Dahan, V Moutardier, E Mitry, JL Van Laethe, JB Bachet, J Cros, J Iovanna, NJ Dusetti
    Translational Oncology, 2021;16(0):101315.
    Species: Human
    Sample Types: Organoid
    Applications: Bioassay
  34. Induced organoids derived from patients with ulcerative colitis recapitulate colitic reactivity
    Authors: SK Sarvestani, S Signs, B Hu, Y Yeu, H Feng, Y Ni, DR Hill, RC Fisher, S Ferrandon, RK DeHaan, J Stiene, M Cruise, TH Hwang, X Shen, JR Spence, EH Huang
    Nature Communications, 2021;12(1):262.
    Species: Human
    Sample Types: Organoid
    Applications: Bioassay
  35. A pan-cancer organoid platform for precision medicine
    Authors: BM Larsen, M Kannan, LF Langer, BD Leibowitz, A Bentaieb, A Cancino, I Dolgalev, BE Drummond, JR Dry, CS Ho, G Khullar, BA Krantz, B Mapes, KE McKinnon, J Metti, JF Perera, TA Rand, V Sanchez-Fr, JM Shaxted, MM Stein, MA Streit, YC Tan, Y Zhang, E Zhao, J Venkataram, MC Stumpe, JA Borgia, A Masood, DVT Catenacci, JV Mathews, DB Gursel, JJ Wei, TH Welling, DM Simeone, KP White, AA Khan, C Igartua, AA Salahudeen
    Cell Reports, 2021;36(4):109429.
    Species: Human
    Sample Types: Organoid
    Applications: Bioassay
  36. MeCP2 controls neural stem cell fate specification through miR-199a-mediated inhibition of BMP-Smad signaling
    Authors: H Nakashima, K Tsujimura, K Irie, T Imamura, CA Trujillo, M Ishizu, M Uesaka, M Pan, H Noguchi, K Okada, K Aoyagi, T Andoh-Noda, H Okano, AR Muotri, K Nakashima
    Cell Reports, 2021;35(7):109124.
    Species: Human
    Sample Types: Organoid
    Applications: Bioassay
  37. Farnesyl dimethyl chromanol targets colon cancer stem cells and prevents colorectal cancer metastasis
    Authors: K Husain, D Coppola, CS Yang, MP Malafa
    Scientific Reports, 2021;11(1):2185.
    Species: Human
    Sample Types: Organoid
    Applications: Bioassay
  38. Generation of Functional Brown Adipocytes from Human Pluripotent Stem Cells via Progression through a Paraxial Mesoderm State
    Authors: L Zhang, J Avery, A Yin, AM Singh, TS Cliff, H Yin, S Dalton
    Cell Stem Cell, 2020;0(0):.
    Species: Human
    Sample Types: Organoid
    Applications: Bioassay
  39. GATA3 Mediates a Fast, Irreversible Commitment to BMP4-Driven Differentiation in Human Embryonic Stem Cells
    Authors: A Gunne-Brad, A Sullivan, B Gharibi, RSM Sheriff, A Maity, YF Wang, A Edwards, M Jiang, M Howell, R Goldstone, R Wollman, P East, SDM Santos
    Cell Stem Cell, 2020;26(5):693-706.e9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  40. LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development
    Authors: NK Vinckier, NA Patel, RJ Geusz, A Wang, J Wang, I Matta, AR Harrington, M Wortham, N Wetton, J Wang, US Jhala, MG Rosenfeld, CW Benner, HP Shih, M Sander
    Nat Commun, 2020;11(1):2082.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  41. Transplantation of Neural Precursors Derived from Induced Pluripotent Cells Preserve Perineuronal Nets and Stimulate Neural Plasticity in ALS Rats
    Authors: S Forostyak, O Forostyak, JCF Kwok, N Romanyuk, M Rehorova, J Kriska, G Dayanithi, R Raha-Chowd, P Jendelova, M Anderova, JW Fawcett, E Sykova
    International Journal of Molecular Sciences, 2020;21(24):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  42. Single cell transcriptomics identifies a signaling network coordinating endoderm and mesoderm diversification during foregut organogenesis
    Authors: L Han, P Chaturvedi, K Kishimoto, H Koike, T Nasr, K Iwasawa, K Giesbrecht, PC Witcher, A Eicher, L Haines, Y Lee, JM Shannon, M Morimoto, JM Wells, T Takebe, AM Zorn
    Nat Commun, 2020;11(1):4158.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  43. Dedifferentiation and neuronal repression define familial Alzheimer's disease
    Authors: AB Caldwell, Q Liu, GP Schroth, DR Galasko, SH Yuan, SL Wagner, S Subramania
    Sci Adv, 2020;6(46):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  44. Direct Conversion of Human Stem Cell-Derived Glial Progenitor Cells into GABAergic Interneurons
    Authors: J Giacomoni, A Bruzelius, CA Stamouli, D Rylander O
    Cells, 2020;9(11):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  45. Using systems medicine to identify a therapeutic agent with potential for repurposing in inflammatory bowel disease
    Authors: K Lloyd, S Papoutsopo, E Smith, P Stegmaier, F Bergey, L Morris, M Kittner, H England, D Spiller, MHR White, CA Duckworth, BJ Campbell, V Poroikov, VAP Martins Do, A Kel, W Muller, DM Pritchard, C Probert, MD Burkitt, SysmedIBD
    Dis Model Mech, 2020;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  46. Kinetic modeling of stem cell transcriptome dynamics to identify regulatory modules of normal and disturbed neuroectodermal differentiation
    Authors: J Meisig, N Dreser, M Kapitza, M Henry, T Rotshteyn, J Rahnenführ, JG Hengstler, A Sachinidis, T Waldmann, M Leist, N Blüthgen
    Nucleic Acids Res, 2020;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  47. Generation of intestinal organoids derived from human pluripotent stem cells for drug testing
    Authors: S Yoshida, H Miwa, T Kawachi, S Kume, K Takahashi
    Sci Rep, 2020;10(1):5989.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  48. Single cell transcriptomics identifies a signaling network coordinating endoderm and mesoderm diversification during foregut organogenesis
    Authors: L Han, P Chaturvedi, K Kishimoto, H Koike, T Nasr, K Iwasawa, K Giesbrecht, PC Witcher, A Eicher, L Haines, Y Lee, JM Shannon, M Morimoto, JM Wells, T Takebe, AM Zorn
    Nat Commun, 2020;11(1):4158.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  49. The Fragile X Mental Retardation Protein regulates RIP1K and colorectal cancer resistance to necroptosis
    Authors: A Di Grazia, I Marafini, G Pedini, D Di Fusco, F Laudisi, V Dinallo, E Rosina, C Stolfi, E Franzè, P Sileri, G Sica, G Monteleone, C Bagni, I Monteleone
    Cell Mol Gastroenterol Hepatol, 2020;0(0):.
    Species: Human
    Sample Types: Organoid
    Applications: Bioassay
  50. Generation of Functional Brown Adipocytes from Human Pluripotent Stem Cells via Progression through a Paraxial Mesoderm State
    Authors: L Zhang, J Avery, A Yin, AM Singh, TS Cliff, H Yin, S Dalton
    Cell Stem Cell, 2020;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  51. A microfluidics-based stem cell model of early post-implantation human development
    Authors: Y Zheng, Y Shao, J Fu
    Nature Protocols, 2020;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  52. Modeling Intestinal Epithelial Response to Interferon-&gamma in Induced Pluripotent Stem Cell-Derived Human Intestinal Organoids
    Authors: MJ Workman, E Troisi, SR Targan, CN Svendsen, RJ Barrett
    International Journal of Molecular Sciences, 2020;22(1):.
    Species: Human
    Sample Types: Organoid
    Applications: Bioassay
  53. Direct Reprogramming of Human Fetal- and Stem Cell-Derived Glial Progenitor Cells into Midbrain Dopaminergic Neurons
    Authors: S Nolbrant, J Giacomoni, DB Hoban, A Bruzelius, M Birtele, D Chandler-M, M Pereira, DR Ottosson, SA Goldman, M Parmar
    Stem Cell Reports, 2020;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  54. Noggin depletion in adipocytes promotes obesity in mice
    Authors: AM Blázquez-M, M Jumabay, P Rajbhandar, T Sallam, Y Guo, J Yao, L Vergnes, K Reue, L Zhang, Y Yao, AM Fogelman, P Tontonoz, AJ Lusis, X Wu, KI Boström
    Mol Metab, 2019;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  55. Patient-derived pancreas-on-a-chip to model cystic fibrosis-related disorders
    Authors: K Shik Mun, K Arora, Y Huang, F Yang, S Yarlagadda, Y Ramananda, M Abu-El-Hai, JJ Palermo, BN Appakalai, JD Nathan, AP Naren
    Nat Commun, 2019;10(1):3124.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  56. Blockade of STAT3 Causes Severe In Vitro and In Vivo Maturation Defects in Intestinal Organoids Derived from Human Embryonic Stem Cells
    Authors: KB Jung, O Kwon, MO Lee, H Lee, YS Son, O Habib, JH Oh, HS Cho, CR Jung, J Kim, MY Son
    J Clin Med, 2019;8(7):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  57. Human induced pluripotent stem cell-derived vocal fold mucosa mimics development and responses to smoke exposure
    Authors: V Lungova, X Chen, Z Wang, C Kendziorsk, SL Thibeault
    Nat Commun, 2019;10(1):4161.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  58. Blockade of STAT3 Causes Severe In Vitro and In Vivo Maturation Defects in Intestinal Organoids Derived from Human Embryonic Stem Cells
    Authors: KB Jung, O Kwon, MO Lee, H Lee, YS Son, O Habib, JH Oh, HS Cho, CR Jung, J Kim, MY Son
    J Clin Med, 2019;8(7):.
    Species: Human
    Sample Types: Organoid
    Applications: Bioassay
  59. Generation of human antral and fundic gastric organoids from pluripotent stem cells
    Authors: TR Broda, KW McCracken, JM Wells
    Nat Protoc, 2019;14(1):28-50.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  60. Generation of lung organoids from human pluripotent stem cells in vitro
    Authors: AJ Miller, BR Dye, D Ferrer-Tor, DR Hill, AW Overeem, LD Shea, JR Spence
    Nat Protoc, 2019;14(2):518-540.
    Species: Human
    Sample Types: Whole Tissue
    Applications: Bioassay
  61. Point mutations in the PDX1 transactivation domain impair human ?-cell development and function
    Authors: X Wang, M Sterr, Ansarullah, I Burtscher, A Böttcher, J Beckenbaue, J Siehler, T Meitinger, HU Häring, H Staiger, FM Cernilogar, G Schotta, M Irmler, J Beckers, CVE Wright, M Bakhti, H Lickert
    Mol Metab, 2019;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Differentiation
  62. Structurally Conserved Primate LncRNAs Are Transiently Expressed during Human Cortical Differentiation and Influence Cell-Type-Specific Genes
    Authors: AR Field, FMJ Jacobs, IT Fiddes, APR Phillips, AM Reyes-Orti, E LaMontagne, L Whitehead, V Meng, JL Rosenkrant, M Olsen, M Hauessler, S Katzman, SR Salama, D Haussler
    Stem Cell Reports, 2019;12(2):245-257.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  63. Brain-stiffness-mimicking tilapia collagen gel promotes the induction of dorsal cortical neurons from human pluripotent stem cells
    Authors: M Iwashita, H Ohta, T Fujisawa, M Cho, M Ikeya, S Kidoaki, Y Kosodo
    Sci Rep, 2019;9(1):3068.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  64. Excess growth hormone suppresses DNA damage repair in epithelial cells
    Authors: V Chesnokova, S Zonis, R Barrett, H Kameda, K Wawrowsky, A Ben-Shlomo, M Yamamoto, J Gleeson, C Bresee, V Gorbunova, S Melmed
    JCI Insight, 2019;4(3):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  65. Controlled modelling of human epiblast and amnion development using stem cells
    Authors: Y Zheng, X Xue, Y Shao, S Wang, SN Esfahani, Z Li, JM Muncie, JN Lakins, VM Weaver, DL Gumucio, J Fu
    Nature, 2019;573(7774):421-425.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  66. BMP signaling mediates glioma stem cell quiescence and confers treatment resistance in glioblastoma
    Authors: R Sachdeva, M Wu, K Johnson, H Kim, A Celebre, U Shahzad, MS Graham, JA Kessler, JH Chuang, J Karamchand, M Bredel, R Verhaak, S Das
    Sci Rep, 2019;9(1):14569.
    Species: Human
    Sample Types: Whole Cells
    Applications: Tissue Culture
  67. Activin A receptor type 1-mediated BMP signaling regulates RANKL-induced osteoclastogenesis via canonical SMAD signaling pathway
    Authors: M Omi, V Kaartinen, Y Mishina
    J. Biol. Chem., 2019;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  68. Differential susceptibility of human neural progenitors and neurons to ischaemic injury
    Authors: Y Liu, AE Michalska, M Dottori, E Eaton, JM Courtney, A Antonic, DW Howells
    Brain Res. Bull., 2019;156(0):25-32.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  69. The Effect of iPS-Derived Neural Progenitors Seeded on Laminin-Coated pHEMA-MOETACl Hydrogel with Dual Porosity in a Rat Model of Chronic Spinal Cord Injury
    Authors: J Ruzicka, N Romanyuk, K Jirakova, A Hejcl, O Janouskova, LU Machova, M Bochin, M Pradny, L Vargova, P Jendelova
    Cell Transplant, 2019;0(0):9636897188237.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  70. Gain of 20q11.21 in Human Pluripotent Stem Cells Impairs TGF-?-Dependent Neuroectodermal Commitment
    Authors: C Markouli, EC De Deckers, M Regin, HT Nguyen, F Zambelli, A Keller, D Dziedzicka, J De Kock, L Tilleman, F Van Nieuwe, L Franceschi, K Sermon, M Geens, C Spits
    Stem Cell Reports, 2019;13(1):163-176.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  71. Examining the fundamental biology of a novel population of directly reprogrammed human neural precursor cells
    Authors: JE Ahlfors, A Azimi, R El-Ayoubi, A Velumian, I Vonderwald, C Boscher, O Mihai, S Mani, M Samoilova, M Khazaei, MG Fehlings, CM Morshead
    Stem Cell Res Ther, 2019;10(1):166.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  72. Medial artery calcification increases neointimal hyperplasia after balloon injury
    Authors: AP Marshall, W Luo, XL Wang, T Lin, Y Cai, RJ Guzman
    Sci Rep, 2019;9(1):8193.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  73. Organotypic Cocultures of Human Pluripotent Stem Cell Derived-Neurons with Mammalian Inner Ear Hair Cells and Cochlear Nucleus Slices
    Authors: T Hyakumura, S McDougall, S Finch, K Needham, M Dottori, BA Nayagam
    Stem Cells Int, 2019;2019(0):8419493.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  74. High-throughput screens for agonists of bone morphogenetic protein (BMP) signaling identify potent benzoxazole compounds
    Authors: STJ Bradford, EJ Ranghini, E Grimley, PH Lee, GR Dressler
    J. Biol. Chem., 2019;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  75. Rfx6 promotes the differentiation of peptide-secreting enteroendocrine cells while�repressing genetic programs controlling�serotonin production
    Authors: J Piccand, C Vagne, F Blot, A Meunier, A Beucher, P Strasser, ML Lund, S Ghimire, L Nivlet, C Lapp, N Petersen, MS Engelstoft, C Thibault-C, C Keime, SJ Correa, V Schreiber, N Molina, TW Schwartz, A De Arcange, G Gradwohl
    Mol Metab, 2019;29(0):24-39.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  76. Sufu- and Spop-mediated downregulation of Hedgehog signaling promotes beta cell differentiation through organ-specific niche signals
    Authors: T Yung, F Poon, M Liang, S Coquenlorg, EC McGaugh, CC Hui, MD Wilson, MC Nostro, TH Kim
    Nat Commun, 2019;10(1):4647.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  77. Oligodendrocyte Intrinsic miR-27a Controls Myelination and Remyelination
    Authors: A Tripathi, C Volsko, JP Garcia, E Agirre, KC Allan, PJ Tesar, BD Trapp, G Castelo-Br, FJ Sim, R Dutta
    Cell Rep, 2019;29(4):904-919.e9.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  78. Canonical Wnt signaling promotes pacemaker cell specification of cardiac mesodermal cells derived from mouse and human embryonic stem cells
    Authors: W Liang, P Han, EH Kim, J Mak, R Zhang, AG Torrente, JI Goldhaber, E Marbán, HC Cho
    Stem Cells, 2019;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  79. Targeting chemoresistant colorectal cancer via systemic administration of a BMP7 variant
    Authors: V Veschi, LR Mangiapane, A Nicotra, S Di Franco, E Scavo, T Apuzzo, DS Sardina, M Fiori, A Benfante, ML Colorito, G Cocorullo, F Giuliante, C Cipolla, G Pistone, MR Bongiorno, A Rizzo, CM Tate, X Wu, S Rowlinson, LF Stancato, M Todaro, R De Maria, G Stassi
    Oncogene, 2019;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  80. Enhanced Utilization of Induced Pluripotent Stem Cell-Derived Human Intestinal Organoids Using Microengineered Chips.
    Authors: Michael J Workman, John P Gleeson, Elissa J Troisi, Hannah Q Estrada, S Jordan Kerns, Christopher D Hinojosa, Geraldine A Hamilton, Stephan R Targan, Clive N Svendsen, Robert J Barrett
    Cellular and Molecular Gastroenterology and Hepatology, 2018;0(0):2352-345X.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  81. Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa
    Authors: A Buskin, L Zhu, V Chichagova, B Basu, S Mozaffari-, D Dolan, A Droop, J Collin, R Bronstein, S Mehrotra, M Farkas, G Hilgen, K White, KT Pan, A Treumann, D Hallam, K Bialas, G Chung, C Mellough, Y Ding, N Krasnogor, S Przyborski, S Zwolinski, J Al-Aama, S Alharthi, Y Xu, G Wheway, K Szymanska, M McKibbin, CF Inglehearn, DJ Elliott, S Lindsay, RR Ali, DH Steel, L Armstrong, E Sernagor, H Urlaub, E Pierce, R Lührmann, SN Grellschei, CA Johnson, M Lako
    Nat Commun, 2018;9(1):4234.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  82. Microbiota-Derived Indole Metabolites Promote Human and Murine Intestinal Homeostasis through Regulation of Interleukin-10 Receptor
    Authors: EE Alexeev, JM Lanis, DJ Kao, EL Campbell, CJ Kelly, KD Battista, ME Gerich, BR Jenkins, ST Walk, DJ Kominsky, SP Colgan
    Am. J. Pathol., 2018;0(0):.
    Species: Human
    Sample Types: Organoid
    Applications: Bioassay
  83. Natural molecules induce and synergize to boost expression of the human antimicrobial peptide ?-defensin-3
    Authors: E Sechet, E Telford, C Bonamy, PJ Sansonetti, B Sperandio
    Proc. Natl. Acad. Sci. U.S.A., 2018;0(0):.
    Species: Human
    Sample Types: Organoids
    Applications: Bioassay
  84. Lysosomal and network alterations in human mucopolysaccharidosis type VII iPSC-derived neurons
    Authors: N Bayó-Puxan, AP Terrasso, S Creyssels, D Simão, C Begon-Pesc, M Lavigne, S Salinas, F Bernex, A Bosch, V Kalatzis, T Levade, AM Cuervo, P Lory, A Consiglio, C Brito, EJ Kremer
    Sci Rep, 2018;8(1):16644.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  85. Pancreatic Cell Fate Determination Relies on Notch Ligand Trafficking by NFIA
    Authors: MA Scavuzzo, J Chmielowie, D Yang, K Wamble, LS Chaboub, L Duraine, B Tepe, SM Glasgow, BR Arenkiel, C Brou, B Deneen, M Borowiak
    Cell Rep, 2018;25(13):3811-3827.e7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  86. Decoding the dynamic DNA methylation and hydroxymethylation landscapes in endodermal lineage intermediates during pancreatic differentiation of hESC
    Authors: J Li, X Wu, Y Zhou, M Lee, L Guo, W Han, W Mo, WM Cao, D Sun, R Xie, Y Huang
    Nucleic Acids Res., 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  87. Enhanced Utilization of Induced Pluripotent Stem Cell-Derived Human Intestinal Organoids Using Microengineered Chips
    Authors: MJ Workman, JP Gleeson, EJ Troisi, HQ Estrada, SJ Kerns, CD Hinojosa, GA Hamilton, SR Targan, CN Svendsen, RJ Barrett
    Cell Mol Gastroenterol Hepatol, 2018;5(4):669-677.e2.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  88. Random Mutagenesis, Clonal Events, and Embryonic or Somatic Origin Determine the mtDNA Variant Type and Load in Human Pluripotent Stem�Cells
    Authors: F Zambelli, J Mertens, D Dziedzicka, J Sterckx, C Markouli, A Keller, P Tropel, L Jung, S Viville, H Van de Vel, M Geens, S Seneca, K Sermon, C Spits
    Stem Cell Reports, 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  89. Genome-wide analysis of PDX1 target genes in human pancreatic progenitors
    Authors: X Wang, M Sterr, I Burtscher, S Chen, A Hieronimus, F Machicao, H Staiger, HU Häring, G Lederer, T Meitinger, FM Cernilogar, G Schotta, M Irmler, J Beckers, M Hrab? de A, M Ray, CVE Wright, M Bakhti, H Lickert
    Mol Metab, 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  90. Enhanced differentiation of human pluripotent stem cells into pancreatic progenitors co-expressing PDX1 and NKX6.1
    Authors: B Memon, M Karam, S Al-Khawaga, EM Abdelalim
    Stem Cell Res Ther, 2018;9(1):15.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  91. Cardiotrophic Growth Factor-Driven Induction of Human Muse Cells Into Cardiomyocyte-Like Phenotype
    Authors: M Amin, Y Kushida, S Wakao, M Kitada, K Tatsumi, M Dezawa
    Cell Transplant, 2018;27(2):285-298.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  92. Sequential Application of Discrete Topographical Patterns Enhances Derivation of Functional Mesencephalic Dopaminergic Neurons from Human Induced Pluripotent Stem Cells
    Authors: KKB Tan, WWM Lim, C Chai, M Kukumberg, KL Lim, ELK Goh, EKF Yim
    Sci Rep, 2018;8(1):9567.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  93. BMP/SMAD pathway promotes neurogenesis of midbrain dopaminergic neurons in vivo and in human induced pluripotent and neural stem cells
    Authors: VM Jovanovic, A Salti, H Tilleman, K Zega, MM Jukic, H Zou, RH Friedel, N Prakash, S Blaess, F Edenhofer, C Brodski
    J. Neurosci., 2018;0(0):.
    Species: Human
    Sample Types:
  94. Human Pluripotent Stem-Cell-Derived Cortical Neurons Integrate Functionally into the Lesioned Adult Murine Visual Cortex in an Area-Specific Way
    Authors: I Espuny-Cam, KA Michelsen, D Linaro, A Bilheu, S Acosta-Ver, A Herpoel, M Giugliano, A Gaillard, P Vanderhaeg
    Cell Rep, 2018;23(9):2732-2743.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  95. DEPTOR regulates osteogenic differentiation via inhibiting MEG3-mediated activation of BMP4 signaling and is involved in osteoporosis
    Authors: S Chen, L Jia, S Zhang, Y Zheng, Y Zhou
    Stem Cell Res Ther, 2018;9(1):185.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  96. Graphene foam as a biocompatible scaffold for culturing human neurons
    Authors: GM D'Abaco, C Mattei, B Nasr, EJ Hudson, AJ Alshawaf, G Chana, IP Everall, B Nayagam, M Dottori, E Skafidas
    R Soc Open Sci, 2018;5(3):171364.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  97. Identification of direct negative crosstalk between the SLIT2 and Bone Morphogenetic Protein-Gremlin signaling pathways
    Authors: KE Tumelty, N Higginson-, X Fan, P Bajaj, KM Knowlton, M Shamashkin, AJ Coyle, W Lu, SP Berasi
    J. Biol. Chem., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  98. 3D Modeling of Esophageal Development using Human PSC-Derived Basal Progenitors Reveals a Critical Role for Notch Signaling
    Authors: Y Zhang, Y Yang, M Jiang, SX Huang, W Zhang, D Al Alam, S Danopoulos, M Mori, YW Chen, R Balasubram, SM Chuva de S, C Serra, M Bialecka, E Kim, S Lin, ALR Toste de C, PN Riccio, WV Cardoso, X Zhang, HW Snoeck, J Que
    Cell Stem Cell, 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  99. Expression of the human antimicrobial peptide ?-defensin-1 is repressed by the EGFR-ERK-MYC axis in colonic epithelial cells
    Authors: C Bonamy, E Sechet, A Amiot, A Alam, M Mourez, L Fraisse, PJ Sansonetti, B Sperandio
    Sci Rep, 2018;8(1):18043.
    Species: Human
    Sample Types: Organoids
    Applications: Bioassay
  100. A transient DMSO treatment increases the differentiation potential of human pluripotent stem cells through the Rb family
    Authors: J Li, C Narayanan, J Bian, D Sambo, T Brickler, W Zhang, S Chetty
    PLoS ONE, 2018;13(12):e0208110.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  101. Derivation of phenotypically diverse neural culture from hESC by combining adherent and dissociation methods
    Authors: Y Liu, A Antonic, X Yang, N Korte, K Lim, AE Michalska, M Dottori, DW Howells
    J. Neurosci. Methods, 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  102. PEG-4MAL hydrogels for human organoid generation, culture, and in vivo delivery
    Authors: R Cruz-Acuña, M Quirós, S Huang, D Siuda, JR Spence, A Nusrat, AJ García
    Nat Protoc, 2018;0(0):.
    Species: Human
    Sample Types: Organoids
    Applications: Bioassay
  103. Self-Renewing Trophoblast Organoids Recapitulate the Developmental Program of the Early Human Placenta
    Authors: S Haider, G Meinhardt, L Saleh, V Kunihs, M Gamperl, U Kaindl, A Ellinger, TR Burkard, C Fiala, J Pollheimer, S Mendjan, PA Latos, M Knöfler
    Stem Cell Reports, 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  104. Genetically engineered human cortical spheroid models of tuberous sclerosis
    Authors: JD Blair, D Hockemeyer, HS Bateup
    Nat. Med., 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  105. Endocrine lineage biases arise in temporally distinct endocrine progenitors during pancreatic morphogenesis
    Authors: MA Scavuzzo, MC Hill, J Chmielowie, D Yang, J Teaw, K Sheng, Y Kong, M Bettini, C Zong, JF Martin, M Borowiak
    Nat Commun, 2018;9(1):3356.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  106. A pluripotent stem cell-based model for post-implantation human amniotic sac development
    Authors: Y Shao, K Taniguchi, RF Townshend, T Miki, DL Gumucio, J Fu
    Nat Commun, 2017;8(1):208.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  107. REST suppression mediates neural conversion of adult human fibroblasts via microRNA-dependent and -independent pathways
    Authors: J Drouin-Oue, S Lau, PL Brattås, D Rylander O, K Pircs, DA Grassi, LM Collins, R Vuono, A Andersson, G Westergren, C Graff, L Minthon, H Toresson, RA Barker, J Jakobsson, M Parmar
    EMBO Mol Med, 2017;9(8):1117-1131.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  108. A hypomorphic PIGA gene mutation causes severe defects in neuron development and susceptibility to complement-mediated toxicity in a human iPSC model
    Authors: X Yuan, Z Li, AC Baines, E Gavriilaki, Z Ye, Z Wen, EM Braunstein, LG Biesecker, L Cheng, X Dong, RA Brodsky
    PLoS ONE, 2017;12(4):e0174074.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  109. Differentiation of oligodendrocyte progenitor cells from dissociated monolayer and feeder-free cultured pluripotent stem cells
    Authors: T Yamashita, Y Miyamoto, Y Bando, T Ono, S Kobayashi, A Doi, T Araki, Y Kato, T Shirakawa, Y Suzuki, J Yamauchi, S Yoshida, N Sato
    PLoS ONE, 2017;12(2):e0171947.
    Species: Primate
    Sample Types: Whole Cells
    Applications: Bioassay
  110. Zeb2 is a negative regulator of midbrain dopaminergic axon growth and target innervation
    Authors: SV Hegarty, SL Wyatt, L Howard, E Stappers, D Huylebroec, AM Sullivan, GW O'Keeffe
    Sci Rep, 2017;7(1):8568.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  111. Bone morphogenetic protein signaling mediated by ALK-2 and DLX2 regulates apoptosis in glioma-initiating cells
    Authors: E Raja, A Komuro, R Tanabe, S Sakai, Y Ino, N Saito, T Todo, M Morikawa, H Aburatani, D Koinuma, C Iwata, K Miyazono
    Oncogene, 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  112. Directly Converted Human Fibroblasts Mature to Neurons and Show Long-Term Survival in Adult Rodent Hippocampus
    Authors: N Avaliani, U Pfisterer, A Heuer, M Parmar, M Kokaia, M Andersson
    Stem Cells Int, 2017;2017(0):5718608.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  113. Epigenetic and transcriptional modulation of WDR5, a chromatin remodeling protein, in Huntington's disease human induced pluripotent stem cell (hiPSC) model
    Authors: S Baronchell, A La Spada, A Ntai, A Barbieri, P Conforti, GS Jotti, S Redaelli, A Bentivegna, P De Blasio, I Biunno
    Mol. Cell. Neurosci., 2017;82(0):46-57.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  114. A right-handed signalling pathway drives heart looping in vertebrates
    Authors: OH Ocaña, H Coskun, C Minguillón, P Murawala, EM Tanaka, J Galcerán, R Muñoz-Cháp, MA Nieto
    Nature, 2017;549(7670):86-90.
    Species: Zebrafish
    Sample Types: Whole Tissue
    Applications: Bioassay
  115. Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor-Mediated Cellular Reprogramming
    Authors: T Ruetz, U Pfisterer, B Di Stefano, J Ashmore, M Beniazza, TV Tian, DF Kaemena, L Tosti, W Tan, JR Manning, E Chantzoura, DR Ottosson, S Collombet, A Johnsson, E Cohen, K Yusa, S Linnarsson, T Graf, M Parmar, K Kaji
    Cell Stem Cell, 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  116. TRAIL attenuates RANKL-mediated osteoblastic signalling in vascular cell mono-culture and co-culture models
    Authors: E Harper, KD Rochfort, H Forde, C Davenport, D Smith, PM Cummins
    PLoS ONE, 2017;12(11):e0188192.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  117. Common genetic variation drives molecular heterogeneity in human iPSCs
    Authors: H Kilpinen, A Goncalves, A Leha, V Afzal, K Alasoo, S Ashford, S Bala, D Bensaddek, FP Casale, OJ Culley, P Danecek, A Faulconbri, PW Harrison, A Kathuria, D McCarthy, SA McCarthy, R Meleckyte, Y Memari, N Moens, F Soares, A Mann, I Streeter, CA Agu, A Alderton, R Nelson, S Harper, M Patel, A White, SR Patel, L Clarke, R Halai, CM Kirton, A Kolb-Kokoc, P Beales, E Birney, D Danovi, AI Lamond, WH Ouwehand, L Vallier, FM Watt, R Durbin, O Stegle, DJ Gaffney
    Nature, 2017;546(7658):370-375.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  118. Differentiation of Human Pluripotent Stem Cells into Colonic Organoids via Transient Activation of BMP Signaling
    Authors: JO Múnera, N Sundaram, SA Rankin, D Hill, C Watson, M Mahe, JE Vallance, NF Shroyer, KL Sinagoga, A Zarzoso-La, JR Hudson, JC Howell, P Chatuvedi, JR Spence, JM Shannon, AM Zorn, MA Helmrath, JM Wells
    Cell Stem Cell, 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  119. Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitors
    Authors: KF Cogger, A Sinha, F Sarangi, EC McGaugh, D Saunders, C Dorrell, S Mejia-Guer, Y Aghazadeh, JL Rourke, RA Screaton, M Grompe, PR Streeter, AC Powers, M Brissova, T Kislinger, MC Nostro
    Nat Commun, 2017;8(1):331.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  120. Establishment of a refined culture method for rat colon organoids
    Authors: H Isshiki, Y Arimura, K Nagaishi, K Kawakami, K Onodera, K Yamashita, Y Naishiro, M Fujimiya, K Imai, Y Shinomura
    Biochem. Biophys. Res. Commun., 2017;0(0):.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  121. Species-specific developmental timing is maintained by pluripotent stem cells ex utero
    Authors: C Barry, MT Schmitz, P Jiang, MP Schwartz, BM Duffin, S Swanson, R Bacher, JM Bolin, AL Elwell, BE McIntosh, R Stewart, JA Thomson
    Dev. Biol., 2017;423(2):101-110.
    Species: Human
    Sample Types: Whole Cells
    Applications: Differentiation
  122. Wnt/?-catenin promotes gastric fundus specification in mice and humans
    Authors: KW McCracken, E Aihara, B Martin, CM Crawford, T Broda, J Treguier, X Zhang, JM Shannon, MH Montrose, JM Wells
    Nature, 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  123. Melanoma-Derived iPCCs Show Differential Tumorigenicity and Therapy Response
    Authors: M Bernhardt, D Novak, Y Assenov, E Orouji, N Knappe, K Weina, M Reith, L Larribere, C Gebhardt, C Plass, V Umansky, J Utikal
    Stem Cell Reports, 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  124. Reductive carboxylation is a major metabolic pathway in the retinal pigment epithelium
    Proc. Natl. Acad. Sci. U.S.A., 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  125. Remyelination Is Correlated with Regulatory T Cell Induction Following Human Embryoid Body-Derived Neural Precursor Cell Transplantation in a Viral Model of Multiple Sclerosis
    Authors: Warren C Plaisted
    PLoS ONE, 2016;11(6):e0157620.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  126. BMP4/Id2 signaling pathway is a novel therapeutic target for late outgrowth endothelial progenitor cell-mediated endothelial injury repair
    Authors: Jun Tao
    Int. J. Cardiol., 2016;228(0):796-804.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  127. Altered neuronal network and rescue in a human MECP2 duplication model
    Mol. Psychiatry, 2016;21(2):178-88.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  128. Growth hormone is permissive for neoplastic colon growth
    Proc Natl Acad Sci USA, 2016;0(0):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: Bioassay
  129. Resveratrol ameliorates the maturation process of beta-cell-like cells obtained from an optimized differentiation protocol of human embryonic stem cells.
    Authors: Pezzolla D, Lopez-Beas J, Lachaud C, Dominguez-Rodriguez A, Smani T, Hmadcha A, Soria B
    PLoS ONE, 2015;10(3):e0119904.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  130. In vitro generation of human pluripotent stem cell derived lung organoids.
    Authors: Dye, Briana R, Hill, David R, Ferguson, Michael, Tsai, Yu-Hwai, Nagy, Melinda, Dyal, Rachel, Wells, James M, Mayhew, Christop, Nattiv, Roy, Klein, Ophir D, White, Eric S, Deutsch, Gail H, Spence, Jason R
    Elife, 2015;4(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  131. A dynamic Shh expression pattern, regulated by SHH and BMP signaling, coordinates fusion of primordia in the amniote face.
    Authors: Hu D, Young N, Li X, Xu Y, Hallgrimsson B, Marcucio R
    Development, 2015;142(3):567-74.
    Species: Chicken
    Sample Types: Whole Organism
    Applications: In Vivo
  132. The in vitro generation of lung and airway progenitor cells from human pluripotent stem cells.
    Authors: Huang S, Green M, de Carvalho A, Mumau M, Chen Y, D'Souza S, Snoeck H
    Nat Protoc, 2015;10(3):413-25.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  133. Early intervention for spinal cord injury with human induced pluripotent stem cells oligodendrocyte progenitors.
    Authors: All A, Gharibani P, Gupta S, Bazley F, Pashai N, Chou B, Shah S, Resar L, Cheng L, Gearhart J, Kerr C
    PLoS ONE, 2015;10(1):e0116933.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  134. Persistence and toxin production by Clostridium difficile within human intestinal organoids result in disruption of epithelial paracellular barrier function.
    Authors: Leslie J, Huang S, Opp J, Nagy M, Kobayashi M, Young V, Spence J
    Infect Immun, 2015;83(1):138-45.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  135. TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors.
    Authors: Cebola I, Rodriguez-Segui S, Cho C, Bessa J, Rovira M, Luengo M, Chhatriwala M, Berry A, Ponsa-Cobas J, Maestro M, Jennings R, Pasquali L, Moran I, Castro N, Hanley N, Gomez-Skarmeta J, Vallier L, Ferrer J
    Nat Cell Biol, 2015;17(5):615-26.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  136. SMAD4 exerts a tumor-promoting role in hepatocellular carcinoma.
    Authors: Hernanda P, Chen K, Das A, Sideras K, Wang W, Li J, Cao W, Bots S, Kodach L, de Man R, Ijzermans J, Janssen H, Stubbs A, Sprengers D, Bruno M, Metselaar H, ten Hagen T, Kwekkeboom J, Peppelenbosch M, Pan Q
    Oncogene, 2015;34(39):5055-68.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  137. Selective lentiviral gene delivery to CD133-expressing human glioblastoma stem cells.
    Authors: Bayin, N Sumru, Modrek, Aram S, Dietrich, August, Lebowitz, Jonathan, Abel, Tobias, Song, Hae-Ri, Schober, Markus, Zagzag, David, Buchholz, Christia, Chao, Moses V, Placantonakis, Dimitris
    PLoS ONE, 2014;9(12):e116114.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  138. Dual small-molecule targeting of SMAD signaling stimulates human induced pluripotent stem cells toward neural lineages.
    Authors: Wattanapanitch M, Klincumhom N, Potirat P, Amornpisutt R, Lorthongpanich C, U-pratya Y, Laowtammathron C, Kheolamai P, Poungvarin N, Issaragrisil S
    PLoS ONE, 2014;9(9):e106952.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  139. Highly efficient generation of induced neurons from human fibroblasts that survive transplantation into the adult rat brain.
    Authors: Pereira, Maria, Pfisterer, Ulrich, Rylander, Daniella, Torper, Olof, Lau, Shong, Lundblad, Martin, Grealish, Shane, Parmar, Malin
    Sci Rep, 2014;4(0):6330.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  140. Retinoic acid signalling regulates the development of tonotopically patterned hair cells in the chicken cochlea.
    Authors: Thiede B, Mann Z, Chang W, Ku Y, Son Y, Lovett M, Kelley M, Corwin J
    Nat Commun, 2014;5(0):3840.
    Species: Chicken
    Sample Types: Whole Tissue
    Applications: Bioassay
  141. Influence of in vitro and in vivo oxygen modulation on beta cell differentiation from human embryonic stem cells.
    Authors: Cechin S, Alvarez-Cubela S, Giraldo J, Molano R, Villate S, Ricordi C, Pileggi A, Inverardi L, Fraker C, Dominguez-Bendala J
    Stem Cells Transl Med, 2014;3(3):277-89.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  142. Real-time discrimination between proliferation and neuronal and astroglial differentiation of human neural stem cells.
    Authors: Lee, Rimi, Kim, Il-Sun, Han, Nalae, Yun, Seokhwan, Park, Kook In, Yoo, Kyung-Hw
    Sci Rep, 2014;4(0):6319.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  143. CEP290 gene transfer rescues Leber congenital amaurosis cellular phenotype.
    Authors: Burnight E, Wiley L, Drack A, Braun T, Anfinson K, Kaalberg E, Halder J, Affatigato L, Mullins R, Stone E, Tucker B
    Gene Ther, 2014;21(7):662-72.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  144. Primary cilia in stem cells and neural progenitors are regulated by neutral sphingomyelinase 2 and ceramide.
    Authors: He Q, Wang G, Wakade S, Dasgupta S, Dinkins M, Kong J, Spassieva S, Bieberich E
    Mol Biol Cell, 2014;25(11):1715-29.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  145. A gradient of Bmp7 specifies the tonotopic axis in the developing inner ear.
    Authors: Mann Z, Thiede B, Chang W, Shin J, May-Simera H, Lovett M, Corwin J, Kelley M
    Nat Commun, 2014;5(0):3839.
    Species: Chicken
    Sample Types: Whole Cells
    Applications: Bioassay
  146. Recessive mutations in a distal PTF1A enhancer cause isolated pancreatic agenesis.
    Authors: Weedon M, Cebola I, Patch A, Flanagan S, De Franco E, Caswell R, Rodriguez-Segui S, Shaw-Smith C, Cho C, Lango Allen H, Houghton J, Roth C, Chen R, Hussain K, Marsh P, Vallier L, Murray A, Ellard S, Ferrer J, Hattersley A
    Nat Genet, 2014;46(1):61-4.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  147. Bone morphogenetic protein 2 signaling negatively modulates lymphatic development in vertebrate embryos.
    Authors: Dunworth, William, Cardona-Costa, Jose, Bozkulak, Esra Cag, Kim, Jun-Dae, Meadows, Stryder, Fischer, Johanna, Wang, Yeqi, Cleaver, Ondine, Qyang, Yibing, Ober, Elke A, Jin, Suk-Won
    Circ Res, 2014;114(1):56-66.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  148. Defined human pluripotent stem cell culture enables highly efficient neuroepithelium derivation without small molecule inhibitors.
    Authors: Lippmann E, Estevez-Silva M, Ashton R
    Stem Cells, 2014;32(4):1032-42.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  149. Endodermal differentiation of human pluripotent stem cells to insulin-producing cells in 3D culture.
    Authors: Takeuchi, Hiroki, Nakatsuji, Norio, Suemori, Hirofumi
    Sci Rep, 2014;4(0):4488.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  150. Inner ear hair cell-like cells from human embryonic stem cells.
    Authors: Ronaghi, Mohammad, Nasr, Marjan, Ealy, Megan, Durruthy-Durruthy, Robert, Waldhaus, Joerg, Diaz, Giovanni, Joubert, Lydia-Ma, Oshima, Kazuo, Heller, Stefan
    Stem Cells Dev, 2014;23(11):1275-84.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  151. Polycomb group protein expression during differentiation of human embryonic stem cells into pancreatic lineage in vitro.
    Authors: Pethe, Prasad, Nagvenkar, Punam, Bhartiya, Deepa
    BMC Cell Biol, 2014;15(0):18.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  152. A synthetic peptide-acrylate surface for production of insulin-producing cells from human embryonic stem cells.
    Authors: Lin P, Hung S, Yang Y, Liao L, Hsieh Y, Yen H, Lu H, Lee M, Chu I, Hwang S
    Stem Cells Dev, 2014;23(4):372-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  153. Rapid and efficient differentiation of human pluripotent stem cells into intermediate mesoderm that forms tubules expressing kidney proximal tubular markers.
    Authors: Lam A, Freedman B, Morizane R, Lerou P, Valerius M, Bonventre J
    J Am Soc Nephrol, 2014;25(6):1211-25.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  154. Inhibition of bone morphogenic protein 4 restores endothelial function in db/db diabetic mice.
    Authors: Zhang Y, Liu J, Tian X, Wong W, Chen Y, Wang L, Luo J, Cheang W, Lau C, Kwan K, Wang N, Yao X, Huang Y
    Arterioscler Thromb Vasc Biol, 2014;34(1):152-9.
    Species: Mouse
    Sample Types: Whole Organism
    Applications: In Vivo
  155. Prospectively isolated NGN3-expressing progenitors from human embryonic stem cells give rise to pancreatic endocrine cells.
    Authors: Cai, Qing, Bonfanti, Paola, Sambathkumar, Rangaraj, Vanuytsel, Kim, Vanhove, Jolien, Gysemans, Conny, Debiec-Rychter, Maria, Raitano, Susanna, Heimberg, Harry, Ordovas, Laura, Verfaillie, Catherin
    Stem Cells Transl Med, 2014;3(4):489-99.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  156. Optimal effector functions in human natural killer cells rely upon autocrine bone morphogenetic protein signaling.
    Authors: Robson N, Hidalgo L, McAlpine T, Wei H, Martinez V, Entrena A, Melen G, MacDonald A, Phythian-Adams A, Sacedon R, Maraskovsky E, Cebon J, Ramirez M, Vicente A, Varas A
    Cancer Res, 2014;74(18):5019-31.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  157. Activation of the type I interferon pathway is enhanced in response to human neuronal differentiation.
    Authors: Farmer, Jocelyn, Altschaefl, Kate M, O'Shea, K Sue, Miller, David J
    PLoS ONE, 2013;8(3):e58813.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  158. Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions.
    Authors: Brafman D, Phung C, Kumar N, Willert K
    Cell Death Differ, 2013;20(3):369-81.
  159. Patient-specific iPSC-derived photoreceptor precursor cells as a means to investigate retinitis pigmentosa.
    Authors: Tucker, Budd A, Mullins, Robert F, Streb, Luan M, Anfinson, Kristin, Eyestone, Mari E, Kaalberg, Emily, Riker, Megan J, Drack, Arlene V, Braun, Terry A, Stone, Edwin M
    Elife, 2013;2(0):e00824.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  160. Bone morphogenetic protein-2/-4 upregulation promoted by endothelial cells in coculture enhances mouse embryoid body differentiation.
    Authors: Talavera-Adame, Dodanim, Gupta, Ankur, Kurtovic, Silvia, Chaiboonma, Kira L, Arumugaswami, Vaithili, Dafoe, Donald C
    Stem Cells Dev, 2013;22(24):3252-60.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  161. Generation of multipotent foregut stem cells from human pluripotent stem cells.
    Authors: Hannan, Nicholas, Fordham, Robert P, Syed, Yasir A, Moignard, Victoria, Berry, Andrew, Bautista, Ruben, Hanley, Neil A, Jensen, Kim B, Vallier, Ludovic
    Stem Cell Reports, 2013;1(4):293-306.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  162. Directed differentiation and functional maturation of cortical interneurons from human embryonic stem cells.
    Authors: Maroof A, Keros S, Tyson J, Ying S, Ganat Y, Merkle F, Liu B, Goulburn A, Stanley E, Elefanty A, Widmer H, Eggan K, Goldstein P, Anderson S, Studer L
    Cell Stem Cell, 2013;12(5):559-72.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  163. Enrichment of human embryonic stem cell-derived NKX6.1-expressing pancreatic progenitor cells accelerates the maturation of insulin-secreting cells in vivo.
    Authors: Rezania A, Bruin J, Xu J, Narayan K, Fox J, O'Neil J, Kieffer T
    Stem Cells, 2013;31(11):2432-42.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  164. Rapid and efficient directed differentiation of human pluripotent stem cells into retinal pigmented epithelium.
    Authors: Buchholz, David E, Pennington, Britney, Croze, Roxanne, Hinman, Cassidy, Coffey, Peter J, Clegg, Dennis O
    Stem Cells Transl Med, 2013;2(5):384-93.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  165. Cited2 gene controls pluripotency and cardiomyocyte differentiation of murine embryonic stem cells through Oct4 gene.
    Authors: Li Q, Ramirez-Bergeron D, Dunwoodie S, Yang Y
    J Biol Chem, 2012;287(34):29088-100.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  166. Interplay between electrical activity and bone morphogenetic protein signaling regulates spinal neuron differentiation.
    Authors: Swapna, Immani, Borodinsky, Laura N
    Proc Natl Acad Sci U S A, 2012;109(40):16336-41.
    Species: Xenopus
    Sample Types: Whole Tissue
    Applications: Bioassay
  167. Downregulation of hemojuvelin prevents inhibitory effects of bone morphogenetic proteins on iron metabolism in hepatocellular carcinoma.
    Authors: Maegdefrau U, Arndt S, Kivorski G, Hellerbrand C, Bosserhoff AK
    Lab. Invest., 2011;91(11):1615-23.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  168. Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro.
    Authors: Spence JR, Mayhew CN, Rankin SA
    Nature, 2011;470(7332):105-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  169. A defined glycosaminoglycan-binding substratum for human pluripotent stem cells.
    Authors: Klim JR, Li L, Wrighton PJ
    Nat. Methods, 2010;7(12):989-94.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  170. Translating dosage compensation to trisomy 21.
    Authors: Jiang J, Jing Y, Cost G, Chiang J, Kolpa H, Cotton A, Carone D, Carone B, Shivak D, Guschin D, Pearl J, Rebar E, Byron M, Gregory P, Brown C, Urnov F, Hall L, Lawrence J
    Nature, 0;500(7462):296-300.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  171. Asynchronous mixing of kidney progenitor cells potentiates nephrogenesis in organoids.
    Authors: Kumar Gupta A, Sarkar P, Wertheim J, Pan X, Carroll T, Oxburgh L
    Commun Biol, 0;3(1):231.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay

FAQs

  1. What is the half life of Recombinant Human Noggin Protein (Catalog # 6057-NG) in vitro?

    • Recombinant Human Noggin Protein (Catalog # 6057-NG) is evaluated for bioactivity by its ability to inhibit BMP-4-induced alkaline phosphatase production in mouse chondrogenic cells in vitro. We have not evaluated the half-life of 6057-NG.  The half-life of a specific protein will depend on experimental conditions, including the cell number, density, and media content. It is up to the end-users to determine the appropriate concentration and timing when adding 6057-NG to individual experiments. For techniques and methodologies, we recommend reviewing our list of publications under the Citations tab on the product-specific web page to find reported use of our products in similar experimental layouts.

  2. Has Recombinant Human Noggin Protein (Catalog # 6057-NG or 6057-NG/CF) been evaluated in vivo?

    • Recombinant Human Noggin Protein (Catalog # 6057-NG) is evaluated for bioactivity by its ability to inhibit BMP-4-induced alkaline phosphatase production in mouse chondrogenic cells in vitro. We have not evaluated this protein for activity in vivo, but we are aware of publications citing use of the protein this type of experimentation. We recommend reviewing our list of publications under the Citations tab on the product-specific web page to find reported use of our products in similar experimental layouts.

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Reviews for Recombinant Human Noggin Protein

Average Rating: 4.5 (Based on 8 Reviews)

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Recombinant Human Noggin Protein
By Anonymous on 09/26/2021
Application: Stem/Immune cell maintenance or differentiation

Used for iPSC differentiation into intestinal organoids at a concentration of 100ng/mL


Recombinant Human Noggin Protein
By Ermali Aliaj on 01/02/2021
Application: Cell Culture

Recombinant Human Noggin Protein
By Anonymous on 12/28/2020
Application: CellProlif
Reason for Rating: Cells grew well.

Recombinant Human Noggin Protein
By Anonymous on 04/05/2019
Application: Stem/Immune cell maintenance or differentiation

Recombinant Human Noggin Protein
By Anonymous on 12/22/2017
Application: Cell Culture

combination of a low dose of Noggin and the bone morphogenetic protein


By Anonymous on 04/25/2017

Recombinant Human Noggin Protein
By Anonymous on 01/04/2017
Application: Neural differentiation of iPSCs. Image is Nestin(Green), Sox1 (red) staining.

Recombinant Human Noggin Protein
By Anonymous on 10/26/2015

Noggin (100 ng/ml) was added into DMEM/F12 (plus B27 and N2) medium to promote neurogenesis of human-induced pluripotent stem cells.