Recombinant Human TGF-beta 1 Protein

Effects of pirfenidone targeting the tumor microenvironment and tumor-stroma interaction as a novel treatment for non-small cell lung cancer
Authors: A Fujiwara, S Funaki, E Fukui, K Kimura, T Kanou, N Ose, M Minami, Y Shintani
Sci Rep, 2020;10(1):10900.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Melatonin ameliorates necrotizing enterocolitis by preventing Th17/Treg imbalance through activation of the AMPK/SIRT1 pathway
Authors: F Ma, H Hao, X Gao, Y Cai, J Zhou, P Liang, J Lv, Q He, C Shi, D Hu, B Chen, L Zhu, X Xiao, S Li
Theranostics, 2020;10(17):7730-7746.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Targeting the Notch and TGF-&beta signaling pathways to prevent retinal fibrosis in vitro and in vivo
Authors: J Fan, W Shen, SR Lee, AE Mathai, R Zhang, G Xu, MC Gillies
Theranostics, 2020;10(18):7956-7973.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal
Authors: MND Svensson, M Zoccheddu, S Yang, G Nygaard, C Secchi, KM Doody, K Slowikowsk, F Mizoguchi, F Humby, R Hands, E Santelli, C Sacchetti, K Wakabayash, DJ Wu, C Barback, R Ai, W Wang, GP Sims, P Mydel, T Kasama, DL Boyle, F Galimi, D Vera, ML Tremblay, S Raychaudhu, MB Brenner, GS Firestein, C Pitzalis, AH Ekwall, SM Stanford, N Bottini
Sci Adv, 2020;6(26):eaba4353.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Role of RANK-L as a potential inducer of ILC2-mediated type 2 inflammation in chronic rhinosinusitis with nasal polyps
Authors: N Ogasawara, JA Poposki, AI Klingler, BK Tan, KE Hulse, WW Stevens, AT Peters, LC Grammer, KC Welch, SS Smith, DB Conley, JR Raviv, P Soroosh, KI Takano, T Himi, RC Kern, RP Schleimer, A Kato
Mucosal Immunol, 2020;13(1):86-95.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Developmental plasticity allows outside-in immune responses by resident memory T cells
Authors: R Fonseca, LK Beura, CF Quarnstrom, HE Ghoneim, Y Fan, CC Zebley, MC Scott, NJ Fares-Fred, S Wijeyesing, EA Thompson, H Borges da, V Vezys, B Youngblood, D Masopust
Nat. Immunol., 2020;0(0):.
Species: Human
Sample Types: Cells
Applications: Cell Culture

Src Inhibition Attenuates Liver Fibrosis by Preventing Hepatic Stellate Cell Activation and Decreasing Connetive Tissue Growth Factor
Authors: HY Seo, SH Lee, JH Lee, YN Kang, JS Hwang, KG Park, MK Kim, BK Jang
Cells, 2020;9(3):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

Targeting Src family kinase member Fyn by Saracatinib attenuated liver fibrosis in vitro and in vivo
Authors: G Du, J Wang, T Zhang, Q Ding, X Jia, X Zhao, J Dong, X Yang, S Lu, C Zhang, Z Liu, Z Zeng, R Safadi, R Qi, X Zhao, Z Hong, Y Lu
Cell Death Dis, 2020;11(2):118.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A strategic expression method of miR-29b and its anti-fibrotic effect based on RNA-sequencing analysis
Authors: X Fan, Y Gao, X Zhang, HY Lughmani, DJ Kennedy, ST Haller, SV Pierre, JI Shapiro, J Tian
PLoS ONE, 2020;15(12):e0244065.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

Group V secreted phospholipase A2 plays a protective role against aortic dissection
Authors: K Watanabe, Y Taketomi, Y Miki, K Kugiyama, M Murakami
J. Biol. Chem., 2020;295(30):10092-10111.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

The IAP Antagonist SM-164 Eliminates Triple-Negative Breast Cancer Metastasis to Bone and Lung in Mice
Authors: W Lei, R Duan, J Li, X Liu, A Huston, BF Boyce, Z Yao
Sci Rep, 2020;10(1):7004.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Tumor-associated macrophages promote ovarian cancer cell migration by secreting transforming growth factor beta induced (TGFBI) and tenascin C
Authors: AM Steitz, A Steffes, F Finkernage, A Unger, L Sommerfeld, JM Jansen, U Wagner, J Graumann, R Müller, S Reinartz
Cell Death Dis, 2020;11(4):249.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

IL-35 is critical in suppressing superantigenic Staphylococcus aureus-driven inflammatory Th17 responses in human nasopharynx-associated lymphoid tissue
Authors: R Xu, RK Shears, R Sharma, M Krishna, C Webb, R Ali, X Wei, A Kadioglu, Q Zhang
Mucosal Immunol, 2020;13(3):460-470.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Human Liver Spheroids as a Model to Study Aetiology and Treatment of Hepatic Fibrosis
Authors: T Hurrell, V Kastrinou-, A Fardellas, DFG Hendriks, Å Nordling, I Johansson, A Baze, C Parmentier, L Richert, M Ingelman-S
Cells, 2020;9(4):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Hypoxia and transforming growth factor &beta1 regulation of long non-coding RNA transcriptomes in human pulmonary fibroblasts
Authors: LK Senavirath, C Huang, S Pushparaj, D Xu, L Liu
Physiol Rep, 2020;8(1):e14343.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Fibroblast growth factor 2 accelerates the epithelial-mesenchymal transition in keratinocytes during wound healing process
Authors: Y Koike, M Yozaki, A Utani, H Murota
Sci Rep, 2020;10(1):18545.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Opposing roles of hematopoietic-specific small GTPase Rac2 and the guanine nucleotide exchange factor Vav1 in osteoclast differentiation
Authors: IS Kang, JS Jang, C Kim
Sci Rep, 2020;10(1):7024.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

HOXD9 promote epithelial-mesenchymal transition and metastasis in colorectal carcinoma
Authors: M Liu, Y Xiao, W Tang, J Li, L Hong, W Dai, W Zhang, Y Peng, X Wu, J Wang, Y Chen, Y Bai, J Lin, Q Yang, Y Wang, Z Lin, S Liu, J Xiong, J Wang, L Xiang
Cancer Med, 2020;0(0):.
Species: Human
Sample Types: Whole Cells

Antifibrotic Effects of a Barbituric Acid Derivative on Liver Fibrosis by Blocking the NF-&kappaB Signaling Pathway in Hepatic Stellate Cells
Authors: YH Wang, FM Suk, CL Liu, TL Chen, YC Twu, MH Hsu, YJ Liao
Front Pharmacol, 2020;11(0):388.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Ionizing radiation modulates the phenotype and function of human CD4+ induced regulatory T cells
Authors: SS Beauford, A Kumari, C Garnett-Be
BMC Immunol., 2020;21(1):18.
Species: Human
Sample Types: Whole Cells
Applications: Differentiation

Context specificity of the EMT transcriptional response
Authors: DP Cook, BC Vanderhyde
Nat Commun, 2020;11(1):2142.

Antifibrotic Effects of the Thiazolidinediones in Eosinophilic Esophagitis Pathologic Remodeling: A Preclinical Evaluation
Authors: QM Nhu, L Hsieh, L Dohil, R Dohil, RO Newbury, R Kurten, FJ Moawad, SS Aceves
Clin Transl Gastroenterol, 2020;11(4):e00164.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Intraglomerular Monocyte/Macrophage Infiltration and Macrophage-Myofibroblast Transition during Diabetic Nephropathy Is Regulated by the A2B Adenosine Receptor
Authors: Á Torres, K Muñoz, Y Nahuelpán, AP R Saez, P Mendoza, C Jara, C Cappelli, R Suarez, C Oyarzún, C Quezada, R San Martín
Cells, 2020;9(4):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Proline-rich tyrosine kinase 2 mediates transforming growth factor-beta-induced hepatic stellate cell activation and liver fibrosis
Authors: J Kim, W Kang, SH Kang, SH Park, JY Kim, S Yang, SY Ha, YH Paik
Scientific Reports, 2020;10(1):21018.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Live-cell imaging and analysis reveal cell phenotypic transition dynamics inherently missing in snapshot data
Authors: W Wang, D Douglas, J Zhang, S Kumari, MS Enuameh, Y Dai, CT Wallace, SC Watkins, W Shu, J Xing
Science Advances, 2020;6(36):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

S-endoglin expression is induced in hyperoxia and contributes to altered pulmonary angiogenesis in bronchopulmonary dysplasia development
Authors: Y Lee, J Lee, SK Nam, Y Hoon Jun
Sci Rep, 2020;10(1):3043.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Glutaredoxin deficiency promotes activation of the transforming growth factor beta pathway in airway epithelial cells, in association with fibrotic airway remodeling
Authors: SB Chia, JD Nolin, R Aboushoush, C Erikson, CG Irvin, ME Poynter, J van der Ve, DJ Taatjes, A van der Vl, V Anathy, YMW Janssen-He
Redox Biol, 2020;37(0):101720.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

MicroRNA-148a-3p suppresses epithelial-to-mesenchymal transition and stemness properties via Wnt1-mediated Wnt/&beta-catenin pathway in pancreatic cancer
Authors: X Fu, L Hong, Z Yang, Y Tu, W Xin, M Zha, S Tu, G Sun, Y Li, W Xiao
J Cell Mol Med, 2020;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Wnt3a upregulation is involved in TGF&beta1-induced cardiac hypertrophy
Authors: T Li, X Weng, S Cheng, D Wang, G Cheng, H Gao, Y Li
Cytokine, 2020;0(0):155376.
Species: Rat
Sample Types: Whole Cells
Applications: Cell Culture

TGF&beta promotes widespread enhancer chromatin opening and operates on genomic regulatory domains
Authors: JA Guerrero-M, M Ceballos-C, F Koehler, S Peiró, JC Reyes
Nature Communications, 2020;11(1):6196.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Attenuation of Hypertrophy in Human MSCs via Treatment with a Retinoic Acid Receptor Inverse Agonist
Authors: M Riedl, C Witzmann, M Koch, S Lang, M Kerschbaum, F Baumann, W Krutsch, D Docheva, V Alt, C Pfeifer
Int J Mol Sci, 2020;21(4):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone
Authors: S Khazaei, N De Jay, S Deshmukh, LD Hendrikse, W Jawhar, CCL Chen, LG Mikael, D Faury, DM Marchione, J Lanoix, É Bonneil, T Ishii, SU Jain, K Rossokhata, TS Sihota, R Eveleigh, V Lisi, AS Harutyunya, S Jung, J Karamchand, BC Dickson, R Turcotte, JS Wunder, P Thibault, PW Lewis, BA Garcia, SC Mack, MD Taylor, L Garzia, CL Kleinman, N Jabado
Cancer Discovery, 2020;10(12):1968-1987.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Cancer immunotherapy via targeted TGF-&beta signalling blockade in TH cells
Authors: S Li, M Liu, MH Do, C Chou, EG Stamatiade, BG Nixon, W Shi, X Zhang, P Li, S Gao, KJ Capistrano, H Xu, NV Cheung, MO Li
Nature, 2020;0(0):.
Species: Mouse
Sample Types: Reference Standard

Tsc1 Regulates the Proliferation Capacity of Bone-Marrow Derived Mesenchymal Stem Cells
Authors: MV Guijarro, LS Danielson, M Cañamero, A Nawab, C Abrahan, E Hernando, GD Palmer
Cells, 2020;9(9):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Dual Pharmacological Targeting of HDACs and PDE5 Inhibits Liver Disease Progression in a Mouse Model of Biliary Inflammation and Fibrosis
Authors: A Claveria-C, L Colyn, I Uriarte, MU Latasa, M Arechederr, JM Herranz, L Alvarez, JM Urman, ML Martinez-C, JM Banales, B Sangro, K Rombouts, J Oyarzabal, JJG Marin, C Berasain, MA Avila, MG Fernandez-
Cancers, 2020;12(12):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Enhancer of Zeste Homologue 2 Inhibition Attenuates TGF-? Dependent Hepatic Stellate Cell Activation and Liver Fibrosis
Authors: R Martin-Mat, TM De Assunca, JP Arab, N Jalan-Sakr, U Yaqoob, T Greuter, VK Verma, AJ Mathison, S Cao, G Lomberk, P Mathurin, R Urrutia, RC Huebert, VH Shah
Cell Mol Gastroenterol Hepatol, 2019;7(1):197-209.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Using an in-vivo syngeneic spontaneous metastasis model identifies ID2 as a promoter of breast cancer colonisation in the brain
Authors: M Kijewska, C Viski, F Turrell, A Fitzpatric, A van Weverw, Q Gao, M Iravani, CM Isacke
Breast Cancer Res., 2019;21(1):4.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Trefoil Factor 3 (TFF3) Is Involved in Cell Migration for Skeletal Repair
Authors: K Krüger, S Schmid, F Paulsen, A Ignatius, P Klinger, T Hotfiel, B Swoboda, K Gelse
Int J Mol Sci, 2019;20(17):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Curcumin, but not curcumin-glucuronide, inhibits Smad signaling in TGF?-dependent bone metastatic breast cancer cells and is enriched in bone compared to other tissues
Authors: AG Kunihiro, JA Brickey, JB Frye, PB Luis, C Schneider, JL Funk
J. Nutr. Biochem., 2019;63(0):150-156.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

ETS2 promotes epithelial-to-mesenchymal transition in renal fibrosis by targeting JUNB transcription
Authors: F Yao, X Wang, ZK Cui, H Lan, X Ai, Q Song, Z Chen, J Yang, B Wu, X Bai
Lab. Invest., 2019;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

POH1 contributes to hyperactivation of TGF-? signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-? receptors and caveolin-1
Authors: B Wang, X Xu, Z Yang, L Zhang, Y Liu, A Ma, G Xu, M Tang, T Jing, L Wu, Y Liu
EBioMedicine, 2019;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation
Authors: K Yasuda, Y Kitagawa, R Kawakami, Y Isaka, H Watanabe, G Kondoh, T Kohwi-Shig, S Sakaguchi, K Hirota
Nat Commun, 2019;10(1):549.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

BMP signaling mediates glioma stem cell quiescence and confers treatment resistance in glioblastoma
Authors: R Sachdeva, M Wu, K Johnson, H Kim, A Celebre, U Shahzad, MS Graham, JA Kessler, JH Chuang, J Karamchand, M Bredel, R Verhaak, S Das
Sci Rep, 2019;9(1):14569.
Species: Human
Sample Types: Whole Cells
Applications: Tissue Culture

Proteasome activator PA200 regulates myofibroblast differentiation
Authors: V Welk, T Meul, C Lukas, IE Kammerl, SR Mulay, AC Schamberge, N Semren, IE Fernandez, HJ Anders, A Günther, J Behr, O Eickelberg, M Korfei, S Meiners
Sci Rep, 2019;9(1):15224.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Progranulin attenuates liver fibrosis by downregulating the inflammatory response
Authors: W Yoo, J Lee, KH Noh, S Lee, D Jung, MH Kabir, D Park, C Lee, KS Kwon, JS Kim, S Kim
Cell Death Dis, 2019;10(10):758.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

TGFb1 suppresses the activation of distinct dNK subpopulations in preeclampsia
Authors: J Zhang, CE Dunk, O Shynlova, I Caniggia, SJ Lye
EBioMedicine, 2019;39(0):531-539.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The B Cell Activation-Induced miR-183 Cluster Plays a Minimal Role in Canonical Primary Humoral Responses
Authors: JN Pucella, M Cols, WF Yen, S Xu, J Chaudhuri
J. Immunol., 2019;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Umbilical cord/placenta-derived mesenchymal stem cells inhibit fibrogenic activation in human intestinal myofibroblasts via inhibition of myocardin-related transcription factor A
Authors: YJ Choi, JB Koo, HY Kim, JW Seo, EJ Lee, WR Kim, JY Cho, KB Hahm, SP Hong, DH Kim, JH Yoo
Stem Cell Res Ther, 2019;10(1):291.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Circulating Picomolar Levels of CCL2 Downregulate Ongoing Chronic Experimental Autoimmune Encephalomyelitis by Induction of Regulatory Mechanisms
Authors: N Kaushansky, E Bakos, S Becker-Her, I Shachar, A Ben-Nun
J. Immunol., 2019;0(0):.
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: ELISA Standard

Estrogen receptor-?-miR-1271-SNAI2 feedback loop regulates transforming growth factor-?-induced breast cancer progression
Authors: BW Liu, ZH Yu, AX Chen, JR Chi, J Ge, Y Yu, XC Cao
J. Exp. Clin. Cancer Res., 2019;38(1):109.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Aurora A selective inhibitor LY3295668 leads to dominant mitotic arrest, apoptosis in cancer cells and shows potent preclinical antitumor efficacy
Authors: J Du, L Yan, R Torres, X Gong, H Bian, C Marugán, K Boehnke, C Baquero, YH Hui, SC Chapman, Y Yang, Y Zeng, SM Bogner, RT Foreman, A Capen, GP Donoho, RD Van Horn, DS Barnard, JA Dempsey, RP Beckmann, MS Marshall, LC Chio, Y Qian, YW Webster, A Aggarwal, S Chu, S Bhattachar, LF Stancato, MS Dowless, PW Iversen, JR Manro, JL Walgren, BW Halstead, MZ Dieter, R Martinez, SV Bhagwat, EL Kreklau, MJ Lallena, XS Ye, BKR Patel, C Reinhard, GD Plowman, DA Barda, JR Henry, SG Buchanan, RM Campbell
Mol. Cancer Ther., 2019;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Smad7 Controls Immunoregulatory PDL2/1-PD1 Signaling in Intestinal Inflammation and Autoimmunity
Authors: LP Garo, AK Ajay, M Fujiwara, V Beynon, C Kuhn, G Gabriely, S Sadhukan, R Raheja, S Rubino, HL Weiner, G Murugaiyan
Cell Rep, 2019;28(13):3353-3366.e5.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

Protein kinase C inhibitors override ZEB1-induced chemoresistance in HCC
Authors: R Sreekumar, M Emaduddin, H Al-Saihati, K Moutasim, J Chan, M Spampinato, R Bhome, HM Yuen, C Mescoli, A Vitale, U Cillo, M Rugge, J Primrose, MA Hilal, S Thirdborou, E Tulchinsky, G Thomas, A Mirnezami, AE Sayan
Cell Death Dis, 2019;10(10):703.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Negligible Effect of Sodium Chloride on the Development and Function of TGF-?-Induced CD4+ Foxp3+ Regulatory T Cells
Authors: Y Luo, Y Xue, J Wang, J Dang, Q Fang, G Huang, N Olsen, SG Zheng
Cell Rep, 2019;26(7):1869-1879.e3.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Long non-coding RNA ZEB1-AS1 regulates miR-200b/FSCN1 signaling and enhances migration and invasion induced by TGF-?1 in bladder cancer cells
Authors: R Gao, N Zhang, J Yang, Y Zhu, Z Zhang, J Wang, X Xu, Z Li, X Liu, Z Li, J Li, C Kong, J Bi
J. Exp. Clin. Cancer Res., 2019;38(1):111.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Increased expression of aquaporin-1 in dermal fibroblasts and dermal microvascular endothelial cells possibly contributes to skin fibrosis and edema in patients with systemic sclerosis
Authors: T Yamashita, Y Asano, R Saigusa, T Taniguchi, K Nakamura, S Miura, T Toyama, T Takahashi, Y Ichimura, M Hirabayash, A Yoshizaki, T Miyagaki, M Sugaya, S Sato
J. Dermatol. Sci., 2019;93(1):24-32.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Knockdown of vimentin reduces mesenchymal phenotype of cholangiocytes in the Mdr2-/- mouse model of primary sclerosing cholangitis (PSC)
Authors: T Zhou, K Kyritsi, N Wu, H Francis, Z Yang, L Chen, A O'Brien, L Kennedy, L Ceci, V Meadows, P Kusumanchi, C Wu, L Baiocchi, NJ Skill, R Saxena, A Sybenga, L Xie, S Liangpunsa, F Meng, G Alpini, S Glaser
EBioMedicine, 2019;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A Neutralizing Aptamer to TGFBR2 and miR-145 Antagonism Rescue Cigarette Smoke- and TGF-?-Mediated CFTR Expression
Authors: RK Dutta, S Chinnapaiy, L Rasmussen, SV Raju, HJ Unwalla
Mol. Ther., 2019;27(2):442-455.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Unfolded protein response is an early, non-critical event during hepatic stellate cell activation
Authors: I Mannaerts, LFR Thoen, N Eysackers, FJ Cubero, S Batista Le, I Coldham, I Colle, C Trautwein, LA van Grunsv
Cell Death Dis, 2019;10(2):98.
Species: Mouse
Sample Types: Spheroids
Applications: Bioassay

Inflammation-induced endothelial to mesenchymal transition promotes brain endothelial cell dysfunction and occurs during multiple sclerosis pathophysiology
Authors: C Derada Tro, RD Fontijn, E Gowing, M Charabati, B van Het Ho, I Didouh, SMA van der Po, D Geerts, A Prat, J van Horsse, G Kooij, HE de Vries
Cell Death Dis, 2019;10(2):45.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Fibronectin synthesis, but not ?-smooth muscle expression, is regulated by periostin in gingival healing through FAK/JNK signaling
Authors: SS Kim, GE Nikoloudak, S Michelsons, K Creber, DW Hamilton
Sci Rep, 2019;9(1):2708.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Expression of polydom in dermal neurofibroma and surrounding dermis in von Recklinghausen's disease
Authors: T Kamitani, H Murota, N Arase, M Wataya-Kan, R Sato-Nishi, K Sekiguchi, D Okuzaki, D Motooka, I Katayama
J. Dermatol. Sci., 2019;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Effect of exposure to Asian sand dust-Particulate matter on liver Tenascin-C expression in human cancer cell and mouse hepatic tissue
Authors: YH Lee, DY Kim, SH Jeong, YJ Hwang
J Toxicol Sci, 2019;44(9):633-641.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Interstitial cells in calcified aortic valves have reduced differentiation potential and stem cell-like properties
Authors: M Bogdanova, A Zabirnyk, A Malashiche, KZ Enayati, TA Karlsen, ML Kaljusto, JE Kvitting, E Dissen, GJ Sullivan, A Kostareva, KO Stensløkke, A Rutkovskiy, J Vaage
Sci Rep, 2019;9(1):12934.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Programming of macrophages by UV-irradiated apoptotic cancer cells inhibits cancer progression and lung metastasis
Authors: YB Kim, YH Ahn, JH Jung, YJ Lee, JH Lee, JL Kang
Cell. Mol. Immunol., 2019;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

HMGA2 Contributes to Distant Metastasis and Poor Prognosis by Promoting Angiogenesis in Oral Squamous Cell Carcinoma
Authors: J Sakata, A Hirosue, R Yoshida, K Kawahara, Y Matsuoka, T Yamamoto, M Nakamoto, M Hirayama, N Takahashi, T Nakamura, H Arita, H Nakashima, M Nagata, A Hiraki, M Shinohara, H Nakayama
Int J Mol Sci, 2019;20(10):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Langerhans Cells Sense Staphylococcus aureus Wall Teichoic Acid through Langerin To Induce Inflammatory Responses
Authors: R van Dalen, JS De La Cruz, M Rumpret, FF Fuchsberge, NH van Teijli, J Hanske, C Rademacher, TBH Geijtenbee, JAG van Strijp, C Weidenmaie, A Peschel, DH Kaplan, NM van Sorge
MBio, 2019;10(3):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Active Tonic mTORC1 Signals Shape Baseline Translation in Naive T Cells
Authors: DR Myers, E Norlin, Y Vercoulen, JP Roose
Cell Rep, 2019;27(6):1858-1874.e6.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Overexpression of ZEB2-AS1 promotes epithelial-to-mesenchymal transition and metastasis by stabilizing ZEB2 mRNA in head neck squamous cell carcinoma
Authors: P Diao, H Ge, Y Song, Y Wu, J Li, Z Li, J Yang, Y Wang, J Cheng
J. Cell. Mol. Med., 2019;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

SMAD3 directly regulates cell cycle genes to maintain arrest in granulosa cells of mouse primordial follicles
Authors: S Granados-A, K Hardy, S Franks, IB Sharum, SL Waite, MA Fenwick
Sci Rep, 2019;9(1):6513.
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay

Micheliolide ameliorates renal fibrosis by suppressing the Mtdh/BMP/MAPK pathway
Authors: F Peng, H Li, S Li, Y Wang, W Liu, W Gong, B Yin, S Chen, Y Zhang, C Luo, W Zhou, Y Chen, P Li, Q Huang, Z Xu, H Long
Lab. Invest., 2019;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Antifibrotic effects of 2-carba cyclic phosphatidic acid (2ccPA) in systemic sclerosis: contribution to the novel treatment
Authors: T Higuchi, K Takagi, A Tochimoto, Y Ichimura, T Norose, Y Katsumata, I Masuda, H Yamanaka, T Morohoshi, Y Kawaguchi
Arthritis Res. Ther., 2019;21(1):103.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Long intergenic non-coding RNAs regulate human lung fibroblast function: Implications for idiopathic pulmonary fibrosis
Authors: MR Hadjichara, BT Roux, E Csomor, CA Feghali-Bo, LA Murray, DL Clarke, MA Lindsay
Sci Rep, 2019;9(1):6020.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Fibrillin-1, a novel TGF-beta-induced factor, is preferentially expressed in metaplastic carcinoma with spindle sarcomatous metaplasia
Authors: HC Lien, YH Lee, YL Juang, YT Lu
Pathology, 2019;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Nemo-like Kinase Drives Foxp3 Stability and Is Critical for Maintenance of Immune Tolerance by Regulatory T Cells
Authors: V Fleskens, CM Minutti, X Wu, P Wei, CEGM Pals, J McCrae, S Hemmers, V Groenewold, HJ Vos, A Rudensky, F Pan, H Li, DM Zaiss, PJ Coffer
Cell Rep, 2019;26(13):3600-3612.e6.
Species: Human
Sample Types: Whole Cells

Identification of serum metabolites associating with chronic kidney disease progression and anti-fibrotic effect of 5-methoxytryptophan
Authors: DQ Chen, G Cao, H Chen, CP Argyopoulo, H Yu, W Su, L Chen, DC Samuels, S Zhuang, GP Bayliss, S Zhao, XY Yu, ND Vaziri, M Wang, D Liu, JR Mao, SX Ma, J Zhao, Y Zhang, YQ Shang, H Kang, F Ye, XH Cheng, XR Li, L Zhang, MX Meng, Y Guo, YY Zhao
Nat Commun, 2019;10(1):1476.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Targeting of dermal myofibroblasts through death receptor 5 arrests fibrosis in mouse models of scleroderma
Authors: JS Park, Y Oh, YJ Park, O Park, H Yang, S Slania, LK Hummers, AA Shah, HT An, J Jang, MR Horton, J Shin, HC Dietz, E Song, DH Na, EJ Park, K Kim, KC Lee, VV Roschke, J Hanes, MG Pomper, S Lee
Nat Commun, 2019;10(1):1128.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Expression of c-Kit discriminates between two functionally distinct subsets of human type 2 innate lymphoid cells
Authors: T Hochdörfer, C Winkler, K Pardali, J Mjösberg
Eur. J. Immunol., 2019;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Inhibition of vascular smooth muscle cell calcification by vasorin through interference with TGF β1 signaling
Authors: TTD Luong, M Estepa, B Boehme, B Pieske, F Lang, KU Eckardt, J Voelkl, I Alesutan
Cell. Signal., 2019;0(0):109414.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

In Vitro Induction of T Helper 17 Cells by Synergistic Activation of Human Monocyte-Derived Langerhans Cell-Like Cells with Bacterial Agonists
Authors: R Gramlich, E Aliahmadi, M Peiser
Int J Mol Sci, 2019;20(6):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

TGF-?1/p65/MAT2A pathway regulates liver fibrogenesis via intracellular SAM
Authors: K Wang, S Fang, Q Liu, J Gao, X Wang, H Zhu, Z Zhu, F Ji, J Wu, Y Ma, L Hu, X Shen, D Gao, J Zhu, P Liu, H Zhou
EBioMedicine, 2019;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Osmotic induction of cyclooxygenase-2 in RPE cells: Stimulation of inflammasome activation
Authors: L Messerschm, S Fischer, P Wiedemann, A Bringmann, M Hollborn
Mol. Vis., 2019;25(0):329-344.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Cadherin-11 contributes to liver fibrosis induced by carbon tetrachloride
Authors: M Pedroza, S To, J Smith, SK Agarwal
PLoS ONE, 2019;14(7):e0218971.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Sphingosine-1-Phosphate Facilitates Skin Wound Healing by Increasing Angiogenesis and Inflammatory Cell Recruitment with Less Scar Formation
Authors: M Aoki, H Aoki, P Mukhopadhy, T Tsuge, H Yamamoto, NM Matsumoto, E Toyohara, Y Okubo, R Ogawa, K Takabe
Int J Mol Sci, 2019;20(14):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Identification of a pro-angiogenic functional role for FSP1-positive fibroblast subtype in wound healing
Authors: S Saraswati, SMW Marrow, LA Watch, PP Young
Nat Commun, 2019;10(1):3027.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis
Authors: J Argemi, MU Latasa, SR Atkinson, IO Blokhin, V Massey, JP Gue, J Cabezas, JJ Lozano, D Van Booven, A Bell, S Cao, LA Vernetti, JP Arab, M Ventura-Co, LR Edmunds, C Fondevilla, P Stärkel, L Dubuquoy, A Louvet, G Odena, JL Gomez, T Aragon, J Altamirano, J Caballeria, MJ Jurczak, DL Taylor, C Berasain, C Wahlestedt, SP Monga, MY Morgan, P Sancho-Bru, P Mathurin, S Furuya, C Lackner, I Rusyn, VH Shah, MR Thursz, J Mann, MA Avila, R Bataller
Nat Commun, 2019;10(1):3126.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

TGFbeta induces stemness through non-canonical AKT-FOXO3a axis in oral squamous cell carcinoma
Authors: K Li, L Yang, J Li, C Guan, S Zhang, X Lao, D Ouyang, G Zheng, S Gao, D Wang, Y Liang, G Liao
EBioMedicine, 2019;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Proton pump inhibitors attenuate myofibroblast formation associated with thyroid eye disease through the aryl hydrocarbon receptor
Authors: CL Hammond, E Roztocil, RP Phipps, SE Feldon, CF Woeller
PLoS ONE, 2019;14(9):e0222779.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

DNA-PKcs modulates progenitor cell proliferation and fibroblast senescence in idiopathic pulmonary fibrosis
Authors: DM Habiel, MS Hohmann, MS Espindola, AL Coelho, I Jones, H Jones, R Carnibella, I Pinar, F Werdiger, CM Hogaboam
BMC Pulm Med, 2019;19(1):165.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Rational Reprogramming of Cellular States by Combinatorial Perturbation
Authors: J Duan, B Li, M Bhakta, S Xie, P Zhou, NV Munshi, GC Hon
Cell Rep, 2019;27(12):3486-3499.e6.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

In vitro selective cytotoxicity of the dietary chalcone cardamonin (CD) on melanoma compared to healthy cells is mediated by apoptosis
Authors: L Berning, L Scharf, E Aplak, D Stucki, C von Montfo, AS Reichert, W Stahl, P Brenneisen
PLoS ONE, 2019;14(9):e0222267.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

MicroRNA?155 inhibits the proliferation of CD8+ T�cells via upregulating regulatory T cells in vitiligo
Authors: M Lv, Z Li, J Liu, F Lin, Q Zhang, Z Li, Y Wang, K Wang, Y Xu
Mol Med Rep, 2019;20(4):3617-3624.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Oral Tolerance Induction to Newly Introduced Allergen is Favored by a Transforming Growth Factor-beta-Enriched Formula
Authors: S Holvoet, M Perrot, N de Groot, G Prioult, T Mikogami, V Verhasselt, S Nutten
Nutrients, 2019;11(9):.
Species: Mink
Sample Types: Whole Cells
Applications: Bioassay

Plug-and-Play In Vitro Metastasis System toward Recapitulating the Metastatic Cascade
Authors: BS Ni, C Tzao, JH Huang
Sci Rep, 2019;9(1):18110.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Bromodomain and Extraterminal (BET) Protein Inhibition Restores Redox Balance and Inhibits Myofibroblast Activation
Authors: CJW Stock, C Michaeloud, P Leoni, AL Durham, S Mumby, AU Wells, KF Chung, IM Adcock, EA Renzoni, GE Lindahl
Biomed Res Int, 2019;2019(0):1484736.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Strontium Promotes the Proliferation and Osteogenic Differentiation of Human Placental Decidual Basalis- and Bone Marrow-Derived MSCs in a Dose-Dependent Manner
Authors: YZ Huang, CG Wu, HQ Xie, ZY Li, A Silini, O Parolini, Y Wu, L Deng, YC Huang
Stem Cells Int, 2019;2019(0):4242178.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

ST2 blockade mitigates peritoneal fibrosis induced by TGF-beta and high glucose
Authors: YC Kim, KH Kim, S Lee, JW Jo, JY Park, MS Park, B Tsogbadrak, JP Lee, JW Lee, DK Kim, KH Oh, IJ Jang, YS Kim, RH Cha, SH Yang
J. Cell. Mol. Med., 2019;23(10):6872-6884.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Anti-inflammatory cytokines IL-35 and IL-10 block atherogenic lysophosphatidylcholine-induced, mitochondrial ROS-mediated innate immune activation, but spare innate immune memory signature in endothelial cells
Authors: X Li, P Fang, Y Sun, Y Shao, WY Yang, X Jiang, H Wang, X Yang
Redox Biol, 2019;28(0):101373.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Anti-interleukin-6 receptor antibody treatment ameliorates postoperative adhesion formation
Authors: N Uyama, H Tsutsui, S Wu, K Yasuda, E Hatano, XY Qin, S Kojima, J Fujimoto
Sci Rep, 2019;9(1):17558.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P

Pirfenidone inhibits motility of NSCLC cells by interfering with the urokinase system
Authors: M Krämer, P Markart, F Drakopanag, A Mamazhakyp, L Schaefer, M Didiasova, M Wygrecka
Cell. Signal., 2019;65(0):109432.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Repurposing dichloroacetate for the treatment of women with endometriosis
Authors: AW Horne, SF Ahmad, R Carter, I Simitsidel, E Greaves, C Hogg, NM Morton, PTK Saunders
Proc. Natl. Acad. Sci. U.S.A., 2019;116(51):25389-25391.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Hic1 Defines Quiescent Mesenchymal Progenitor Subpopulations with Distinct Functions and Fates in Skeletal Muscle Regeneration
Authors: RW Scott, M Arostegui, R Schweitzer, FMV Rossi, TM Underhill
Cell Stem Cell, 2019;25(6):797-813.e9.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

Integrated analysis of long non-coding RNAs and mRNAs associated with peritendinous fibrosis
Authors: W Zheng, C Chen, S Chen, C Fan, H Ruan
J Adv Res, 2019;15(0):49-58.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

PAK4 Kinase Activity Plays a Crucial Role in the Podosome Ring of Myeloid Cells
Authors: E Foxall, A Staszowska, LM Hirvonen, M Georgouli, M Ciccioli, A Rimmer, L Williams, Y Calle, VS Moreno, S Cox, GE Jones, CM Wells
Cell Rep, 2019;29(11):3385-3393.e6.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Platyconic Acid A, Platycodi Radix-Derived Saponin, Suppresses TGF-1-induced Activation of Hepatic Stellate Cells via Blocking SMAD and Activating the PPAR Signaling Pathway
Authors: JH Choi, SM Kim, GH Lee, SW Jin, HS Lee, YC Chung, HG Jeong
Cells, 2019;8(12):.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Tensin1 expression and function in chronic obstructive pulmonary disease
Authors: P Stylianou, K Clark, B Gooptu, D Smallwood, CE Brightling, Y Amrani, KM Roach, P Bradding
Sci Rep, 2019;9(1):18942.
Species: Human
Sample Types: Whole Cells
Applications: Stimulation

Enhanced osteopontin splicing regulated by RUNX2 is HDAC-dependent and induces invasive phenotypes in NSCLC cells
Authors: J Huang, S Chang, Y Lu, J Wang, Y Si, L Zhang, S Cheng, WG Jiang
Cancer Cell Int., 2019;19(0):306.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

S100A4/non-muscle myosin II signaling regulates epithelial-mesenchymal transition and stemness in uterine carcinosarcoma
Authors: M Tochimoto, Y Oguri, M Hashimura, R Konno, T Matsumoto, A Yokoi, Y Kodera, M Saegusa
Lab. Invest., 2019;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The Transcription Factor MAZR/PATZ1 Regulates the Development of FOXP3+ Regulatory T Cells
Authors: L Andersen, AF Gülich, M Alteneder, T Preglej, MJ Orola, N Dhele, V Stolz, A Schebesta, P Hamminger, A Hladik, S Floess, T Krausgrube, T Faux, SBA Andrabi, J Huehn, S Knapp, T Sparwasser, C Bock, A Laiho, LL Elo, O Rasool, R Lahesmaa, S Sakaguchi, W Ellmeier
Cell Rep, 2019;29(13):4447-4459.e6.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

TGF-beta induces a heart failure phenotype via fibroblasts exosome signaling
Authors: H Basma, AN Johanson, K Dhar, D Anderson, F Qiu, S Rennard, BD Lowes
Heliyon, 2019;5(10):e02633.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Mitophagy dependent macrophage reprogramming protects against kidney fibrosis
Authors: D Bhatia, KP Chung, K Nakahira, E Patino, MC Rice, LK Torres, T Muthukumar, AM Choi, OM Akchurin, ME Choi
JCI Insight, 2019;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Presence of Stromal Cells Enhances Epithelial-to-Mesenchymal Transition (EMT) Induction in Lung Bronchial Epithelium after Protracted Exposure to Oxidative Stress of Gamma Radiation
Authors: A Acheva, S Haghdoost, A Sollazzo, V Launonen, M Kämäräinen
Oxid Med Cell Longev, 2019;2019(0):4120379.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Clonorchis sinensis ESPs enhance the activation of hepatic stellate cells by a cross-talk of TLR4 and TGF-beta/Smads Signaling pathway
Authors: B Li, C Yan, J Wu, K Stephane, X Dong, YZ Zhang, Y Zhang, Q Yu, KY Zheng
Acta Trop., 2019;0(0):105307.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Batf Pioneers the Reorganization of Chromatin in Developing Effector T Cells via Ets1-Dependent Recruitment of Ctcf
Authors: D Pham, CE Moseley, M Gao, D Savic, CJ Winstead, M Sun, BL Kee, RM Myers, CT Weaver, RD Hatton
Cell Rep, 2019;29(5):1203-1220.e7.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Fibroblast growth factor 23 is upregulated in the kidney in a chronic kidney disease rat model
Authors: H Sugiura, A Matsushita, M Futaya, A Teraoka, KI Akiyama, N Usui, N Nagano, K Nitta, K Tsuchiya
PLoS ONE, 2018;13(3):e0191706.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Epigenetic activation during T helper 17 cell differentiation is mediated by Tripartite motif containing 28
Authors: Y Jiang, Y Liu, H Lu, SC Sun, W Jin, X Wang, C Dong
Nat Commun, 2018;9(1):1424.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Luteolin-Mediated Inhibition of Hepatic Stellate Cell Activation via Suppression of the STAT3 Pathway
Authors: CB Cummins, X Wang, O Nunez Lope, G Graham, HY Tie, J Zhou, RS Radhakrish
Int J Mol Sci, 2018;19(6):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Genetic and developmental origins of a unique foraging adaptation in a Lake Malawi cichlid genus
Authors: MR Conith, Y Hu, AJ Conith, MA Maginnis, JF Webb, RC Albertson
Proc. Natl. Acad. Sci. U.S.A., 2018;0(0):.
Species: Fish
Sample Types: In Vivo
Applications: In Vivo

Unique mechanisms of connective tissue growth factor regulation in airway smooth muscle in asthma: Relationship with airway remodelling
Authors: J Wang, A Faiz, Q Ge, CJ Vermeulen, J Van der Ve, KJ Snibson, R van de Vel, S Sawant, D Xenaki, B Oliver, W Timens, N Ten Hacken, M van den Be, A James, JG Elliot, L Dong, JK Burgess, AW Ashton
J. Cell. Mol. Med., 2018;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Reduced Autophagy by a microRNA-mediated Signaling Cascade in Diabetes-induced Renal Glomerular Hypertrophy
Authors: S Deshpande, M Abdollahi, M Wang, L Lanting, M Kato, R Natarajan
Sci Rep, 2018;8(1):6954.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

RGMa mediates reactive astrogliosis and glial scar formation through TGF?1/Smad2/3 signaling after stroke
Authors: R Zhang, Y Wu, F Xie, Y Zhong, Y Wang, M Xu, J Feng, J Charish, PP Monnier, X Qin
Cell Death Differ., 2018;0(0):.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Curcumin inhibits TGF-?1-induced connective tissue growth factor expression through the interruption of Smad2 signaling in human gingival fibroblasts
Authors: JT Chen, CY Wang, MH Chen
J. Formos. Med. Assoc., 2018;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage
Authors: S Nowsheen, K Aziz, A Aziz, M Deng, B Qin, K Luo, KB Jeganathan, H Zhang, T Liu, J Yu, Y Deng, J Yuan, W Ding, JM van Deurse, Z Lou
Nat. Cell Biol., 2018;20(4):455-464.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

The prion protein is embedded in a molecular environment that modulates transforming growth factor ? and integrin signaling
Authors: F Ghodrati, M Mehrabian, D Williams, O Halgas, MEC Bourkas, JC Watts, EF Pai, G Schmitt-Ul
Sci Rep, 2018;8(1):8654.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

A Rapamycin-Based GMP-Compatible Process for the Isolation and Expansion of Regulatory T Cells for Clinical Trials
Authors: H Fraser, N Safinia, N Grageda, S Thirkell, K Lowe, LJ Fry, C Scottá, A Hope, C Fisher, R Hilton, D Game, P Harden, A Bushell, K Wood, RI Lechler, G Lombardi
Mol Ther Methods Clin Dev, 2018;8(0):198-209.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Proteomics-based insights into mitogen-activated protein kinase inhibitor resistance of cerebral melanoma metastases
Authors: N Zila, A Bileck, B Muqaku, L Janker, OM Eichhoff, PF Cheng, R Dummer, MP Levesque, C Gerner, V Paulitschk
Clin Proteomics, 2018;15(0):13.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A distinct isoform of ZNF207 controls self-renewal and pluripotency of human embryonic stem cells
Authors: F Fang, N Xia, B Angulo, J Carey, Z Cady, J Durruthy-D, T Bennett, V Sebastiano, RA Reijo Pera
Nat Commun, 2018;9(1):4384.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Spatial patterning of liver progenitor cell differentiation mediated by cellular contractility and Notch signaling
Authors: KB Kaylan, IC Berg, MJ Biehl, A Brougham-C, I Jain, SM Jamil, LH Sargeant, NJ Cornell, LT Raetzman, GH Underhill
Elife, 2018;7(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Arginine methylation controls the strength of ?c-family cytokine signaling in T cell maintenance
Authors: M Inoue, K Okamoto, A Terashima, T Nitta, R Muro, T Negishi-Ko, T Kitamura, T Nakashima, H Takayanagi
Nat. Immunol., 2018;19(11):1265-1276.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

MicroRNA-21 in cancer-associated fibroblasts supports�lung adenocarcinoma progression
Authors: A Kunita, S Morita, TU Irisa, A Goto, T Niki, D Takai, J Nakajima, M Fukayama
Sci Rep, 2018;8(1):8838.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Comparing Effects of Transforming Growth Factor ?1 on Microglia From Rat and Mouse: Transcriptional Profiles and Potassium Channels
Authors: S Lively, D Lam, R Wong, LC Schlichter
Front Cell Neurosci, 2018;12(0):115.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

TGF-?1 promotes cell barrier function upon maturation of corneal endothelial cells
Authors: V Beaulieu L, O Roy, K Santerre, S Proulx
Sci Rep, 2018;8(1):4438.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

TGF? and IGF1R signaling activate protein kinase A through differential regulation of ezrin phosphorylation in colon cancer�cells
Authors: PD Leiphrakpa, MG Brattain, JD Black, JJ Wang
J. Biol. Chem., 2018;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Expression ratio of the TGF?-inducible gene MYO10 is prognostic for overall survival of squamous cell lung cancer patients and predicts chemotherapy response
Authors: D Dvornikov, MA Schneider, S Ohse, M Szczygie?, I Titkova, M Rosenblatt, T Muley, A Warth, FJ Herth, H Dienemann, M Thomas, J Timmer, M Schilling, H Busch, M Boerries, M Meister, U Klingmülle
Sci Rep, 2018;8(1):9517.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Metastatic Brain Tumors Disrupt the Blood-Brain Barrier and Alter Lipid Metabolism by Inhibiting Expression of the Endothelial Cell Fatty Acid Transporter Mfsd2a
Authors: S Tiwary, JE Morales, SC Kwiatkowsk, FF Lang, G Rao, JH McCarty
Sci Rep, 2018;8(1):8267.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

MicroRNA-212 activates hepatic stellate cells and promotes liver fibrosis via targeting SMAD7
Authors: J Zhu, Z Zhang, Y Zhang, W Li, W Zheng, J Yu, B Wang, L Chen, Q Zhuo, L Chen, J Zhang, J Liu
Biochem. Biophys. Res. Commun., 2018;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Deficiency of primary cilia in kidney epithelial cells induces epithelial to mesenchymal transition
Authors: SJ Han, JK Jung, SS Im, SR Lee, BC Jang, KM Park, JI Kim
Biochem. Biophys. Res. Commun., 2018;0(0):.
Species: Canine
Sample Types: Whole Cells
Applications: Bioassay

TGF-? induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression
Authors: S Ottaviani, J Stebbing, AE Frampton, S Zagorac, J Krell, A de Giorgio, SM Trabulo, VTM Nguyen, L Magnani, H Feng, E Giovannett, N Funel, TM Gress, LR Jiao, Y Lombardo, NR Lemoine, C Heeschen, L Castellano
Nat Commun, 2018;9(1):1845.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

FPPS mediates TGF-?1-induced non-small cell lung cancer cell invasion and the EMT process via the RhoA/Rock1 pathway
Authors: L Lin, M Li, L Lin, X Xu, G Jiang, L Wu
Biochem. Biophys. Res. Commun., 2018;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

CD8+ T cells with high TGF??1 expression cause lymph node fibrosis following HIV infection
Authors: L Huang, J Deng, W Xu, H Wang, L Shi, F Wu, D Wu, W Nei, M Zhao, P Mao, X Zhou
Mol Med Rep, 2018;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Impaired TGF-? signaling in patients with active systemic lupus erythematosus is associated with an overexpression of IL-22
Authors: R Rekik, M Smiti Khan, T Larbi, I Zamali, A Beldi-Ferc, O Kammoun, S Marzouki, S Hamzaoui, S Mrad, MR Barbouche, MH Houman, M Ben Ahmed
Cytokine, 2018;108(0):182-189.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Isolation and characterization of mesenchymal stem cells from human fetus heart
Authors: VNS Garikipati, SP Singh, Y Mohanram, AK Gupta, D Kapoor, S Nityanand
PLoS ONE, 2018;13(2):e0192244.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Modulation of NCAM/FGFR1 signaling suppresses EMT program in human proximal tubular epithelial cells
Authors: M Životi?, B Tampe, G Müller, C Müller, A Lipkovski, X Xu, G Nyamsuren, M Zeisberg, J Markovi?-L
PLoS ONE, 2018;13(11):e0206786.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

miR-200b ameliorates myofibroblast transdifferentiation in precancerous oral submucous fibrosis through targeting ZEB2
Authors: YW Liao, CC Yu, PL Hsieh, YC Chang
J. Cell. Mol. Med., 2018;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

REV-ERB? Regulates TH17 Cell Development and Autoimmunity
Authors: M Amir, S Chaudhari, R Wang, S Campbell, SA Mosure, LB Chopp, Q Lu, J Shang, OB Pelletier, Y He, C Doebelin, MD Cameron, DJ Kojetin, TM Kamenecka, LA Solt
Cell Rep, 2018;25(13):3733-3749.e8.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Akt2 causes TGF?-induced deptor downregulation facilitating mTOR to drive podocyte hypertrophy and matrix protein expression
Authors: F Das, N Ghosh-Chou, DY Lee, Y Gorin, BS Kasinath, GG Choudhury
PLoS ONE, 2018;13(11):e0207285.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Additive effect of bFGF and selenium on expansion and paracrine action of human amniotic fluid-derived mesenchymal stem cells
Authors: J Park, JH Lee, BS Yoon, EK Jun, G Lee, IY Kim, S You
Stem Cell Res Ther, 2018;9(1):293.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The FOXK1-CCDC43 Axis Promotes the Invasion and Metastasis of Colorectal Cancer Cells
Authors: J Wang, G Liu, M Liu, L Xiang, Y Xiao, H Zhu, X Wu, Y Peng, W Zhang, P Jiang, A Li, Q Nan, Y Chen, C Chen, T Cheng, S Liu, J Wang
Cell. Physiol. Biochem., 2018;51(6):2547-2563.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Alterations in exosomal miRNA profile upon epithelial-mesenchymal transition in human lung cancer cell lines
Authors: YT Tang, YY Huang, JH Li, SH Qin, Y Xu, TX An, CC Liu, Q Wang, L Zheng
BMC Genomics, 2018;19(1):802.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

ROCK2, but not ROCK1 interacts with phosphorylated STAT3 and co-occupies TH17/TFH gene promoters in TH17-activated human T cells
Authors: W Chen, MS Nyuydzefe, JM Weiss, J Zhang, SD Waksal, A Zanin-Zhor
Sci Rep, 2018;8(1):16636.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A standardized herbal extract PM014 ameliorates pulmonary fibrosis by suppressing the TGF-?1 pathway
Authors: KH Kim, S Lee, H Lee, D Shin, D Min, M Kim, B Ryu, HW Kim, H Bae
Sci Rep, 2018;8(1):16860.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A Reciprocal Role of the Smad4-Taz Axis in Osteogenesis and Adipogenesis of Mesenchymal Stem Cells
Authors: JS Park, M Kim, NJ Song, JH Kim, D Seo, JH Lee, SM Jung, JY Lee, J Lee, YS Lee, KW Park, SH Park
Stem Cells, 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Mutant Kras-induced upregulation of CD24 enhances prostate cancer stemness and bone metastasis
Authors: CC Weng, PY Ding, YH Liu, JR Hawse, M Subramania, CC Wu, YC Lin, CY Chen, WC Hung, KH Cheng
Oncogene, 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Regulators of Salmonella-host interaction identified by peripheral blood transcriptome profiling: roles of TGFB1 and TRP53 in intracellular Salmonella replication in pigs
Authors: T Huang, X Huang, B Shi, F Wang, W Feng, M Yao
Vet. Res., 2018;49(1):121.
Species: Porcine
Sample Types: Plasma
Applications: Bioassay

P21-activated kinase 2 is essential in maintenance of peripheral Foxp3+ regulatory T cells
Authors: J Choi, DR Pease, S Chen, B Zhang, H Phee
Immunology, 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Peptidylarginine deiminases 2 and 4 modulate innate and adaptive immune responses in TLR-7-dependent lupus
Authors: Y Liu, YL Lightfoot, N Seto, C Carmona-Ri, E Moore, R Goel, L O'Neil, P Mistry, V Hoffmann, S Mondal, PN Premnath, K Gribbons, S Dell'Orso, K Jiang, PR Thompson, HW Sun, SA Coonrod, MJ Kaplan
JCI Insight, 2018;3(23):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

DDIT4 and Associated lncDDIT4 Modulate Th17 Differentiation through the DDIT4/TSC/mTOR Pathway
Authors: F Zhang, G Liu, D Li, C Wei, J Hao
J. Immunol., 2018;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

TGF�1 Cell Cycle Arrest Is Mediated by Inhibition of MCM Assembly in Rb-deficient Conditions
Authors: BS Nepon-Sixt, MG Alexandrow
Mol. Cancer Res., 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Trophic effects of adipose-tissue-derived and bone-marrow-derived mesenchymal stem cells enhance cartilage generation by chondrocytes in co-culture
Authors: MM Pleumeeker, L Nimeskern, JLM Koevoet, M Karperien, KS Stok, GJVM van Osch
PLoS ONE, 2018;13(2):e0190744.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

VHL status regulates transforming growth factor-? signaling pathways in renal cell carcinoma
Authors: P Mallikarju, RT Sitaram, M Landström, B Ljungberg
Oncotarget, 2018;9(23):16297-16310.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

MicroRNA 483-3p targets Pard3 to potentiate TGF-?1-induced cell migration, invasion, and epithelial-mesenchymal transition in anaplastic thyroid cancer cells
Authors: X Zhang, L Liu, X Deng, D Li, H Cai, Y Ma, C Jia, B Wu, Y Fan, Z Lv
Oncogene, 2018;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

D-Mannose Enhanced Immunomodulation of Periodontal Ligament Stem Cells via Inhibiting IL-6 Secretion
Authors: L Guo, Y Hou, L Song, S Zhu, F Lin, Y Bai
Stem Cells Int, 2018;2018(0):7168231.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Biologic canine and human intervertebral disc repair by notochordal cell-derived matrix: from bench towards bedside
Authors: FC Bach, AR Tellegen, M Beukers, A Miranda-Be, M Teunissen, WAM de Jong, SAH de Vries, LB Creemers, K Benz, BP Meij, K Ito, MA Tryfonidou
Oncotarget, 2018;9(41):26507-26526.
Species: Canine
Sample Types: Whole Cells
Applications: Bioassay

Artifact-free high-density localization microscopy analysis
Authors: RJ Marsh, K Pfisterer, P Bennett, LM Hirvonen, M Gautel, GE Jones, S Cox
Nat. Methods, 2018;0(0):.
Species: Human
Sample Types: Transfected Whole Cells
Applications: Bioassay

PyMT-1099, a versatile murine cell model for EMT in breast cancer
Authors: M Saxena, RKR Kalathur, M Neutzner, G Christofor
Sci Rep, 2018;8(1):12123.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Essential role of connective tissue growth factor (CTGF) in transforming growth factor-?1 (TGF-?1)-induced myofibroblast transdifferentiation from Graves' orbital fibroblasts
Authors: CC Tsai, SB Wu, HC Kau, YH Wei
Sci Rep, 2018;8(1):7276.
Applications: ELISA (Standard)

The transcriptomic and epigenetic map of vascular quiescence in the continuous lung endothelium
Authors: K Schlereth, D Weichenhan, T Bauer, T Heumann, E Giannakour, D Lipka, S Jaeger, M Schlesner, P Aloy, R Eils, C Plass, HG Augustin
Elife, 2018;7(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Chondrogenic Differentiation of Defined Equine Mesenchymal Stem Cells Derived from Umbilical Cord Blood for Use in Cartilage Repair Therapy
Authors: M Desancé, R Contentin, L Bertoni, T Gomez-Ledu, T Branly, S Jacquet, JM Betsch, A Batho, F Legendre, F Audigié, P Galéra, M Demoor
Int J Mol Sci, 2018;19(2):.
Species: Equine
Sample Types: Whole Cells
Applications: Bioassay

Injectable cartilaginous template transformed BMSCs into vascularized bone
Authors: X Feng, Z Li, J Wei, Z Feng, W Wu, Y Zhao
Sci Rep, 2018;8(1):8244.
Species: Rabbit
Sample Types: Whole Cells
Applications: Bioassay

Decreased TGFBR3/betaglycan expression enhances the metastatic abilities of renal cell carcinoma cells through TGF-?-dependent and -independent mechanisms
Authors: J Nishida, K Miyazono, S Ehata
Oncogene, 2018;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

FOXM1 is a critical driver of lung fibroblast activation and fibrogenesis
Authors: LR Penke, JM Speth, VL Dommeti, ES White, IL Bergin, M Peters-Gol
J. Clin. Invest., 2018;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

TGF?1-induced Amelotin gene expression is downregulated by Bax expression in mouse gingival epithelial cells
Authors: Y Nakayama, S Matsui, K Noda, M Yamazaki, Y Iwai, B Ganss, Y Ogata
J Oral Sci, 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

CXCL12/CXCR4-Mediated Procollagen Secretion Is Coupled To Cullin-RING Ubiquitin Ligase Activation
Authors: S Patalano, J Rodríguez-, C Colaneri, J Cotellessa, D Almanza, A Zhilin-Rot, T Riley, J Macoska
Sci Rep, 2018;8(1):3499.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Hydrogen sulfide promotes immunomodulation of gingiva-derived mesenchymal stem cells via the Fas/FasL coupling pathway
Authors: R Yang, T Yu, D Liu, S Shi, Y Zhou
Stem Cell Res Ther, 2018;9(1):62.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

EphrinB2/EphB4 signaling regulates non-sprouting angiogenesis by VEGF
Authors: E Groppa, S Brkic, A Uccelli, G Wirth, P Korpisalo-, M Filippova, B Dasen, V Sacchi, MG Muraro, M Trani, S Reginato, R Gianni-Bar, S Ylä-Herttu, A Banfi
EMBO Rep., 2018;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Pericyte ALK5/TIMP3 Axis Contributes to Endothelial Morphogenesis in the Developing Brain
Authors: JM Dave, T Mirabella, SD Weatherbee, DM Greif
Dev. Cell, 2018;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Time-resolved transcriptome and proteome landscape of human regulatory T cell (Treg) differentiation reveals novel regulators of FOXP3
Authors: A Schmidt, F Marabita, NA Kiani, CC Gross, HJ Johansson, S Éliás, S Rautio, M Eriksson, SJ Fernandes, G Silberberg, U Ullah, U Bhatia, H Lähdesmäki, J Lehtiö, D Gomez-Cabr, H Wiendl, R Lahesmaa, J Tegnér
BMC Biol., 2018;16(1):47.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Identification of Epithelial-Mesenchymal Transition-related Target Genes Induced by the Mutation of Smad3 Linker Phosphorylation
Authors: S Park, KM Yang, Y Park, E Hong, CP Hong, J Park, K Pang, J Lee, B Park, S Lee, H An, MK Kwak, J Kim, JM Kang, P Kim, Y Xiao, G Nie, A Ooshima, SJ Kim
J Cancer Prev, 2018;23(1):1-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Hypoxia induces endothelial?mesenchymal transition in pulmonary vascular remodeling
Authors: B Zhang, W Niu, HY Dong, ML Liu, Y Luo, ZC Li
Int. J. Mol. Med., 2018;0(0):.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Metformin ameliorates TGF-β1-induced osteoblastic differentiation of human aortic valve interstitial cells by inhibiting β-catenin signaling
Authors: F Liu, C Chu, Q Wei, J Shi, H Li, N Dong
Biochem. Biophys. Res. Commun., 2018;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Exosomal miR-214 from endometrial stromal cells inhibits endometriosis fibrosis
Authors: D Wu, P Lu, X Mi, J Miao
Mol. Hum. Reprod., 2018;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Hypoxia Enhances Differentiation of Adipose Tissue-Derived Stem Cells toward the Smooth Muscle Phenotype
Authors: F Wang, V Zachar, CP Pennisi, T Fink, Y Maeda, J Emmersen
Int J Mol Sci, 2018;19(2):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Novel inhibitors of the cellular RAS components, Poricoic acids, target Smad3 phosphorylation and Wnt/β-catenin pathway against renal fibrosis
Authors: M Wang, DQ Chen, L Chen, G Cao, H Zhao, D Liu, ND Vaziri, Y Guo, YY Zhao
Br. J. Pharmacol., 2018;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Sulfation degree not origin of chondroitin sulfate derivatives modulates keratinocyte response
Authors: L Corsuto, S Rother, L Koehler, E Bedini, S Moeller, M Schnabelra, V Hintze, C Schiraldi, D Scharnwebe
Carbohydr Polym, 2018;191(0):53-64.
Species: Human
Sample Types: Cell Culture Supernates
Applications: ELISA Standard

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity
Authors: R Gupta, K Somyajit, T Narita, E Maskey, A Stanlie, M Kremer, D Typas, M Lammers, N Mailand, A Nussenzwei, J Lukas, C Choudhary
Cell, 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Actin cytoskeleton assembly regulates collagen production via TGF-? type II receptor in human skin fibroblasts
Authors: Z Qin, GJ Fisher, JJ Voorhees, T Quan
J. Cell. Mol. Med., 2018;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Vitamin A-coupled liposomes containing siRNA against HSP47 ameliorate skin fibrosis in chronic graft-versus-host disease
Authors: T Yamakawa, H Ohigashi, D Hashimoto, E Hayase, S Takahashi, M Miyazaki, K Minomi, M Onozawa, Y Niitsu, T Teshima
Blood, 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

Protective effect of stromal Dickkopf-3 in prostate cancer: opposing roles for TGFBI and ECM-1
Authors: Z Al Shareef, H Kardooni, V Murillo-Ga, G Domenici, E Stylianaki, JH Steel, M Rabano, I Gorroño-Et, I Zabalza, M dM Vivanco, J Waxman, RM Kypta
Oncogene, 2018;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

FK506-binding protein 10 (FKBP10) regulates lung fibroblast migration via collagen VI synthesis
Authors: L Knüppel, K Heinzelman, M Lindner, R Hatz, J Behr, O Eickelberg, CA Staab-Weij
Respir. Res., 2018;19(1):67.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

MicroRNA-663 induces immune dysregulation by inhibiting TGF-?1 production in bone marrow-derived mesenchymal stem cells in patients with systemic lupus erythematosus
Authors: L Geng, X Tang, K Zhou, D Wang, S Wang, G Yao, W Chen, X Gao, W Chen, S Shi, N Shen, X Feng, L Sun
Cell. Mol. Immunol., 2018;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Frizzled-8 integrates Wnt-11 and transforming growth factor-? signaling in prostate cancer
Authors: V Murillo-Ga, I Gorroño-Et, M Åkerfelt, MC Puustinen, L Sistonen, M Nees, J Carton, J Waxman, RM Kypta
Nat Commun, 2018;9(1):1747.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Canonical TGF-? Signaling Pathway Represses Human NK Cell Metabolism
Authors: V Zaiatz-Bit, DK Finlay, CM Gardiner
J. Immunol., 2018;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

RIPK3 promotes kidney fibrosis via AKT-dependent ATP citrate lyase
Authors: M Imamura, JS Moon, KP Chung, K Nakahira, T Muthukumar, R Shingarev, SW Ryter, AM Choi, ME Choi
JCI Insight, 2018;3(3):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

TNFRSF19 inhibits TGF? signaling through interaction with TGF? receptor type I to promote tumorigenesis
Authors: C Deng, YX Lin, XK Qi, GP He, Y Zhang, HJ Zhang, M Xu, QS Feng, JX Bei, YX Zeng, L Feng
Cancer Res., 2018;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

BMP-2 restoration aids in recovery from liver fibrosis by attenuating TGF-?1 signaling
Authors: YH Chung, YH Huang, TH Chu, CL Chen, PR Lin, SC Huang, DC Wu, CC Huang, TH Hu, YH Kao, MH Tai
Lab. Invest., 2018;0(0):.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

In Vitro Regeneration of Patient-specific Ear-shaped Cartilage and Its First Clinical Application for Auricular Reconstruction
Authors: G Zhou, H Jiang, Z Yin, Y Liu, Q Zhang, C Zhang, B Pan, J Zhou, X Zhou, H Sun, D Li, A He, Z Zhang, W Zhang, W Liu, Y Cao
EBioMedicine, 2018;28(0):287-302.
Species: Human
Sample Types: Complex Sample Type
Applications: Bioassay

Interferon-gamma inhibits seminal plasma induction of colony stimulating factor 2 in mouse and human reproductive tract epithelial cells
Authors: DJ Sharkey, DJ Glynn, JE Schjenken, KP Tremellen, SA Robertson
Biol. Reprod., 2018;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Synergistic role of HSP90? and HSP90? to promote myofibroblast persistence in lung fibrosis
Authors: PS Bellaye, C Shimbori, T Yanagihara, DA Carlson, P Hughes, C Upagupta, S Sato, N Wheildon, T Haystead, K Ask, M Kolb
Eur. Respir. J., 2018;51(2):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Role of integrin alpha8 in murine model of lung fibrosis
Authors: CF Hung, CL Wilson, YH Chow, LM Schnapp
PLoS ONE, 2018;13(5):e0197937.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Chloroquine-treated dendritic cells require STAT1 signaling for their tolerogenic activity
Authors: R Thome, AP Bonfanti, J Rasouli, ER Mari, GX Zhang, A Rostami, L Verinaud
Eur. J. Immunol., 2018;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Overexpression of LncRNA AC067945.2 Down-Regulates Collagen Expression in Skin Fibroblasts and Possibly Correlates with the VEGF and Wnt Signalling Pathways
Authors: L Chen, J Li, Q Li, X Li, Y Gao, X Hua, B Zhou, J Li
Cell. Physiol. Biochem., 2018;45(2):761-771.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Role of monocyte chemoattractant protein-1 in liver fibrosis with transient myeloproliferative disorder in down syndrome
Authors: K Kobayashi, T Yoshioka, J Miyauchi, A Nakazawa, N Kiyokawa, T Maihara, I Usami
Hepatol Commun, 2018;2(3):230-236.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

A novel transforming growth factor beta-induced long noncoding RNA promotes an inflammatory microenvironment in human intrahepatic cholangiocarcinoma
Authors: A Merdrignac, G Angenard, C Allain, K Petitjean, D Bergeat, P Bellaud, A Fautrel, B Turlin, B Clément, S Dooley, L Sulpice, K Boudjema, C Coulouarn
Hepatol Commun, 2018;2(3):254-269.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The silencing of LncRNA-H19 decreases chemoresistance of human glioma cells to temozolomide by suppressing epithelial-mesenchymal transition via the Wnt/?-Catenin pathway
Authors: L Jia, Y Tian, Y Chen, G Zhang
Onco Targets Ther, 2018;11(0):313-321.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Microenvironment?driven resistance to B?Raf inhibition in a melanoma patient is accompanied by broad changes of gene methylation and expression in distal fibroblasts
Authors: O Kodet, B Dvo?ánková, B Bendlová, V Sýkorová, I Krajsová, J Štork, J Ku?era, P Szabo, H Strnad, M Kolá?, ? Vl?ek, K Smetana, L Lacina
Int. J. Mol. Med., 2018;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Effects of 5-HT2receptor antagonists on bronchoconstriction and pulmonary remodeling processes
Authors: A Löfdahl, C Wenglén, K Rydell-Tör, G Westergren, AK Larsson-Ca
Am. J. Pathol., 2018;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Endoglin interacts with VEGFR2 to promote angiogenesis
Authors: H Tian, JJ Huang, C Golzio, X Gao, M Hector-Gre, N Katsanis, GC Blobe
FASEB J., 2018;0(0):fj201700867RR.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Identification of a TGF-?-miR-195 positive feedback loop in hepatocytes and its deregulation in hepatoma cells
Authors: R Wang, T Fu, K You, S Li, N Zhao, J Yang, SM Zhuang
FASEB J., 2018;0(0):fj201701199R.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A Newly Discovered Antifibrotic Pathway Regulated by Two Fatty Acid Receptors: GPR40 and GPR84
Authors: L Gagnon, M Leduc, JF Thibodeau, MZ Zhang, B Grouix, F Sarra-Bour, W Gagnon, K Hince, M Tremblay, L Geerts, CRJ Kennedy, RL Hébert, A Gutsol, CE Holterman, E Kamto, L Gervais, J Ouboudinar, J Richard, A Felton, A Laverdure, JC Simard, S Létourneau, MP Cloutier, FA Leblond, SD Abbott, C Penney, JS Duceppe, B Zacharie, J Dupuis, A Calderone, QT Nguyen, RC Harris, P Laurin
Am. J. Pathol., 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

PAWS1 controls Wnt signalling through association with casein kinase 1?
Authors: P Bozatzi, KS Dingwell, KZ Wu, F Cooper, TD Cummins, LD Hutchinson, J Vogt, NT Wood, TJ Macartney, J Varghese, R Gourlay, DG Campbell, JC Smith, GP Sapkota
EMBO Rep., 2018;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Ras enhances TGF-? signaling by decreasing cellular protein levels of its type II receptor negative regulator SPSB1
Authors: S Liu, J Iaria, RJ Simpson, HJ Zhu
Cell Commun. Signal, 2018;16(1):10.
Species: Canine
Sample Types: Whole Cells
Applications: Bioassay

Face morphogenesis is promoted by Pbx-dependent EMT via regulation ofduring frontonasal prominence fusion
Authors: M Losa, M Risolino, B Li, J Hart, L Quintana, I Grishina, H Yang, IF Choi, P Lewicki, S Khan, R Aho, J Feenstra, CT Vincent, AMC Brown, E Ferretti, T Williams, L Selleri
Development, 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

TSC1 and TSC2 regulate cilia length and canonical Hedgehog signaling via different mechanisms
Authors: T Rosengren, LJ Larsen, LB Pedersen, ST Christense, LB Møller
Cell. Mol. Life Sci., 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Mitogen-activated protein kinase inhibitors reduce the nuclear accumulation of phosphorylated Smads by inhibiting Imp 7 or Imp 8 in HepG2 cells
Authors: X Hu, H Kan, A Boye, Y Jiang, C Wu, Y Yang
Oncol Lett, 2018;15(4):4867-4872.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

LINE-1 couples EMT programming with acquisition of oncogenic phenotypes in human bronchial epithelial cells
Authors: EM Reyes-Reye, I Aispuro, MA Tavera-Gar, M Field, S Moore, I Ramos, KS Ramos
Oncotarget, 2017;8(61):103828-103842.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A Relay Pathway between Arginine and Tryptophan Metabolism Confers Immunosuppressive Properties on Dendritic Cells
Authors: G Mondanelli, R Bianchi, MT Pallotta, C Orabona, E Albini, A Iacono, ML Belladonna, C Vacca, F Fallarino, A Macchiarul, S Ugel, V Bronte, F Gevi, L Zolla, A Verhaar, M Peppelenbo, EM Mazza, S Bicciato, Y Laouar, L Santambrog, P Puccetti, C Volpi, U Grohmann
Immunity, 2017;46(2):233-244.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Cytidine monophosphate kinase is inhibited by the TGF-? signalling pathway through the upregulation of miR-130b-3p in human epithelial ovarian cancer
Authors: D Zhou, L Zhang, W Sun, W Guan, Q Lin, W Ren, J Zhang, G Xu
Cell. Signal., 2017;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

HR+HER2- breast cancers with growth factor receptor-mediated EMT have a poor prognosis and lapatinib downregulates EMT in MCF-7 cells
Authors: K Desai, R Aiyappa, JS Prabhu, MG Nair, PV Lawrence, A Korlimarla, A Ce, A Alexander, RS Kaluve, S Manjunath, M Correa, BS Srinath, S Patil, A Kalamdani, M Prasad, TS Sridhar
Tumour Biol, 2017;39(3):1010428317695.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Armc5 deletion causes developmental defects and compromises T-cell immune responses
Authors: Y Hu, L Lao, J Mao, W Jin, H Luo, T Charpentie, S Qi, J Peng, B Hu, MM Marcinkiew, A Lamarre, J Wu
Nat Commun, 2017;8(0):13834.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Osteopontin activates mesenchymal stem cells to repair skin wound
Authors: W Wang, P Li, W Li, J Jiang, Y Cui, S Li, Z Wang
PLoS ONE, 2017;12(9):e0185346.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

TGF-?1 up-regulates cadherin-11 expression through Snail: A potential mechanism for human trophoblast cell differentiation
Authors: JC Cheng, Y Yi, HM Chang, PCK Leung
Cell. Signal., 2017;43(0):55-61.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Transforming growth factor-?1 signaling promotes epithelial-mesenchymal transition-like phenomena, cell motility, and cell invasion in synovial sarcoma cells
Authors: Y Qi, N Wang, Y He, J Zhang, H Zou, W Zhang, W Gu, Y Huang, X Lian, J Hu, J Zhao, X Cui, L Pang, F Li
PLoS ONE, 2017;12(8):e0182680.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Hydrogen Peroxide Enhances TGF?-mediated Epithelial-to-Mesenchymal Transition in Human Mammary Epithelial MCF-10A Cells
Authors: D Iizuka, M Sasatani, MH Barcellos-, K Kamiya
Anticancer Res, 2017;37(3):987-995.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Surfactant Protein B Suppresses Lung Cancer Progression by Inhibiting Secretory Phospholipase A2 Activity and Arachidonic Acid Production
Authors: S Lee, D Kim, J Kang, E Kim, W Kim, H Youn, B Youn
Cell. Physiol. Biochem., 2017;42(4):1684-1700.

Galectin-1 inhibition attenuates profibrotic signaling in hypoxia-induced pulmonary fibrosis
Authors: JJ Kathiriya, N Nakra, J Nixon, PS Patel, V Vaghasiya, A Alhassani, Z Tian, D Allen-Gips, V Davé
Cell Death Discov, 2017;3(0):17010.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Autophagy supports generation of cells with high CD44 expression via modulation of oxidative stress and Parkin-mediated mitochondrial clearance
Authors: KA Whelan, PM Chandramou, K Tanaka, M Natsuizaka, M Guha, S Srinivasan, DS Darling, Y Kita, S Natsugoe, JD Winkler, AJ Klein-Szan, RK Amaravadi, NG Avadhani, AK Rustgi, H Nakagawa
Oncogene, 2017;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Microarray Analysis Reveals Increased Expression of Matrix Metalloproteases and Cytokines of Interleukin-20 Subfamily in the Kidneys of Neonate Rats Underwent Unilateral Ureteral Obstruction: A Potential Role of IL-24 in the Regulation of Inflammation and Tissue Remodeling
Authors: D Pap, E Sziksz, Z Kiss, R Rokonay, A Veres-Szék, R Lippai, IM Takács, É Kis, A Fekete, G Reusz, A Vannay, AJ Szabó
Kidney Blood Press. Res, 2017;42(1):16-32.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Dual function of TGF? in lens epithelial cell fate: implications for secondary cataract
Authors: BA Boswell, A Korol, JA West-Mays, LS Musil
Mol. Biol. Cell, 2017;0(0):.
Species: Chicken
Sample Types: Whole Cells
Applications: Bioassay

Regulation of epithelial-mesenchymal transition and metastasis by TGF-?, P-bodies, and autophagy
Authors: SD Hardy, A Shinde, WH Wang, MK Wendt, RL Geahlen
Oncotarget, 2017;8(61):103302-103314.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

TFAP2A is a component of the ZEB1/2 network that regulates TGFB1-induced epithelial to mesenchymal transition
Authors: Y Dimitrova, AJ Gruber, N Mittal, S Ghosh, B Dimitriade, D Mathow, WA Grandy, G Christofor, M Zavolan
Biol. Direct, 2017;12(1):8.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Supraphysiological levels of GDF11 induce striated muscle atrophy
Authors: DW Hammers, M Merscham-B, JY Hsiao, S Engst, JJ Hartman, HL Sweeney
EMBO Mol Med, 2017;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Dual roles of parathyroid hormone-related protein in TGF-?1 signaling and fibronectin upregulation in mesangial cells
Authors: SZ Wu, SJ Yang, HM Chen, FF Peng, H Yu, JC Kreprinsky, BF Zhang
Biosci. Rep., 2017;0(0):.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

V-set and Ig domain-containing 4 (VSIG4)-expressing hepatic F4/80+ cells regulate oral antigen-specific responses in mouse
Authors: W Shin, Y Jeon, I Choi, YJ Kim
Eur. J. Immunol., 2017;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Cdk5 is required for the neuroprotective effect of transforming growth factor-?1 against cerebral ischemia-reperfusion
Authors: W Zhao, J Yan, L Gao, J Zhao, C Zhao, C Gao, X Luo, X Zhu
Biochem. Biophys. Res. Commun, 2017;0(0):.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

XPLN is modulated by HDAC inhibitors and negatively regulates SPARC expression by targeting mTORC2 in human lung fibroblasts
Authors: K Kamio, A Azuma, J Usuki, K Matsuda, M Inomata, N Nishijima, S Itakura, H Hayashi, T Kashiwada, N Kokuho, K Atsumi, T Yamaguchi, K Fujita, Y Saito, S Abe, K Kubota, A Gemma
Pulm Pharmacol Ther, 2017;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

An autocrine/paracrine circuit of growth differentiation factor (GDF) 15 has a role for maintenance of breast cancer stem-like cells
Authors: A Sasahara, K Tominaga, T Nishimura, M Yano, E Kiyokawa, M Noguchi, M Noguchi, H Kanauchi, T Ogawa, H Minato, K Tada, Y Seto, A Tojo, N Gotoh
Oncotarget, 2017;8(15):24869-24881.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Egr2 and 3 Inhibit T-bet-Mediated IFN-? Production in T Cells
Authors: R Singh, T Miao, ALJ Symonds, B Omodho, S Li, P Wang
J. Immunol., 2017;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Fibronectin-guided migration of carcinoma collectives
Authors: S Gopal, L Veracini, D Grall, C Butori, S Schaub, S Audebert, L Camoin, E Baudelet, A Radwanska, S Beghelli-d, SM Violette, PH Weinreb, S Rekima, M Ilie, A Sudaka, P Hofman, E Van Obberg
Nat Commun, 2017;8(0):14105.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

SMAD1/5 mediates bone morphogenetic protein 2-induced up-regulation of BAMBI expression in human granulosa-lutein cells
Authors: L Bai, HM Chang, JC Cheng, C Klausen, G Chu, PCK Leung, G Yang
Cell. Signal., 2017;37(0):52-61.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Arid5a stabilizes OX40 mRNA in murine CD4+ T cells by recognizing a stem-loop structure in its 3'UTR
Authors: H Hanieh, K Masuda, H Metwally, JP Chalise, M Mohamed, KK Nyati, DM Standley, S Li, M Higa, MM Zaman, T Kishimoto
Eur. J. Immunol., 2017;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Dendritic cells from rheumatoid arthritis patient peripheral blood induce Th17 cell differentiation via miR-363/Integrin ?v/TGF-? axis
Authors: F Pan, H Xiang, J Yan, L Hong, L Zhang, Y Liu, X Feng, C Cai
Scand. J. Immunol., 2017;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

TGF-?1 (Transforming Growth Factor-?1) Plays a Pivotal Role in Cardiac Myofibroblast Arrhythmogenicity
Authors: N Salvarani, A Maguy, SA De Simone, M Miragoli, F Jousset, S Rohr
Circ Arrhythm Electrophysiol, 2017;10(5):e004567.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Immune cell-derived cytokines contribute to obesity-related inflammation, fibrogenesis and metabolic deregulation in human adipose tissue
Authors: C Caër, C Rouault, T Le Roy, C Poitou, J Aron-Wisne, A Torcivia, JC Bichet, K Clément, M Guerre-Mil, S André
Sci Rep, 2017;7(1):3000.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

TGF?1-induced leucine limitation uncovered by differential ribosome codon reading
Authors: F Loayza-Puc, K Rooijers, J Zijlstra, B Moumbeini, EA Zaal, JF Oude Vriel, R Lopes, A Pineiro Ug, CR Berkers, R Agami
EMBO Rep, 2017;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Tubastatin ameliorates pulmonary fibrosis by targeting the TGF?-PI3K-Akt pathway
Authors: S Saito, Y Zhuang, B Shan, S Danchuk, F Luo, M Korfei, A Guenther, JA Lasky
PLoS ONE, 2017;12(10):e0186615.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Discovery and pharmacological characterization of a new class of prolyl-tRNA synthetase inhibitor for anti-fibrosis therapy
Authors: A Shibata, M Kuno, R Adachi, Y Sato, H Hattori, A Matsuda, Y Okuzono, K Igaki, Y Tominari, T Takagi, M Yabuki, M Okaniwa
PLoS ONE, 2017;12(10):e0186587.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor-Mediated Cellular Reprogramming
Authors: T Ruetz, U Pfisterer, B Di Stefano, J Ashmore, M Beniazza, TV Tian, DF Kaemena, L Tosti, W Tan, JR Manning, E Chantzoura, DR Ottosson, S Collombet, A Johnsson, E Cohen, K Yusa, S Linnarsson, T Graf, M Parmar, K Kaji
Cell Stem Cell, 2017;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

TGF-? inhibits IL-7-induced proliferation in memory but not naive human CD4(+) T cells
Authors: TP Nguyen, SF Sieg
J. Leukoc. Biol., 2017;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

TGF?-TAZ/SRF Signaling regulates vascular smooth muscle cell differentiation
Authors: C Pagiatakis, D Sun, SW Tobin, T Miyake, JC McDermott
FEBS J, 2017;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Sphingosine-1-Phosphate Mediates Fibrosis in Orbital Fibroblasts in Graves' Orbitopathy
Authors: J Ko, MK Chae, JH Lee, EJ Lee, JS Yoon
Invest. Ophthalmol. Vis. Sci., 2017;58(5):2544-2553.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Mesenteric lymph node CD11b(-) CD103(+) PD-L1(High) dendritic cells highly induce regulatory T cells
Authors: A Shiokawa, R Kotaki, T Takano, H Nakajima-A, S Hachimura
Immunology, 2017;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Levistilide A inhibits angiogenesis in liver fibrosis via vascular endothelial growth factor signaling pathway
Authors: ZM Zhao, HL Liu, X Sun, T Guo, L Shen, YY Tao, CH Liu
Exp. Biol. Med. (Maywood), 2017;242(9):974-985.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Ganoderma lucidum (Reishi) suppresses proliferation and migration of breast cancer cells via inhibiting Wnt/?-catenin signaling
Authors: Y Zhang
Biochem. Biophys. Res. Commun., 2017;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A ZIP6-ZIP10 heteromer controls NCAM1 phosphorylation and integration into focal adhesion complexes during epithelial-to-mesenchymal transition
Authors: D Brethour, M Mehrabian, D Williams, X Wang, F Ghodrati, S Ehsani, EA Rubie, JR Woodgett, J Sevalle, Z Xi, E Rogaeva, G Schmitt-Ul
Sci Rep, 2017;7(0):40313.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Anti-fibrogenic effect of PPAR-? agonists in human intestinal myofibroblasts
Authors: JB Koo, MO Nam, Y Jung, J Yoo, DH Kim, G Kim, SJ Shin, KM Lee, KB Hahm, JW Kim, SP Hong, KJ Lee, JH Yoo
BMC Gastroenterol, 2017;17(1):73.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A structurally distinct TGF-? mimic from an intestinal helminth parasite potently induces regulatory T cells.
Authors: Chris J C Johnston, Danielle J Smyth, Ravindra B Kodali, Madeleine P J White, Yvonne Harcus, Kara J Filbey, James P Hewitson, Cynthia S Hinck, Alasdair Ivens, Andrea M Kemter, Anna O Kildemoes, Thierry Le Bihan, Dinesh C Soares, Stephen M Anderton, Thomas Brenn, Stephen J Wigmore, Hannah V Woodcock, Rachel C Chambers, Andrew P Hinck, Henry J McSorley, Rick M Maizels
Nature Communications, 2017;0(0):2041-1723.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells via Temporal Regulation of Wnt Signaling
Authors: KB McCauley, F Hawkins, M Serra, DC Thomas, A Jacob, DN Kotton
Cell Stem Cell, 2017;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Fibroblast growth factor 2 (FGF2) regulates cytoglobin expression and activation of human hepatic stellate cells via JNK signaling
Authors: M Sato-Matsu, T Matsubara, A Daikoku, Y Okina, L Longato, K Rombouts, LTT Thuy, J Adachi, T Tomonaga, K Ikeda, K Yoshizato, M Pinzani, N Kawada
J. Biol. Chem., 2017;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Selective Induction of Homeostatic Th17 Cells in the Murine Intestine by Cholera Toxin Interacting with the Microbiota
Authors: Q Zhao, SN Harbour, R Kolde, IJ Latorre, HM Tun, TR Schoeb, H Turner, JJ Moon, E Khafipour, RJ Xavier, CT Weaver, CO Elson
J. Immunol., 2017;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Mesothelial-to-mesenchymal transition as a possible therapeutic target in peritoneal metastasis of ovarian cancer
Authors: A Rynne-Vida, CL Au-Yeung, JA Jiménez-He, ML Pérez-Loza, L Cremades-J, C Bárcena, I Cristóbal-, C Fernández-, TL Yeung, SC Mok, P Sandoval, M López-Cabr
J. Pathol, 2017;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

MDM2 promotes epithelial-mesenchymal transition and metastasis of ovarian cancer SKOV3 cells.
Authors: Ying Chen, Dan-Dan Wang, Ye-Ping Wu, Dan Su, Tian-Yi Zhou, Ren-Hua Gai, Ying-Ying Fu, Lin Zheng, Qiao-Jun He, Hong Zhu, Bo Yang
British Journal of Cancer, 2017;0(0):1532-1827.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Podocalyxin influences malignant potential by controlling epithelial-mesenchymal transition in lung adenocarcinoma
Authors: H Kusumoto, Y Shintani, R Kanzaki, T Kawamura, S Funaki, M Minami, I Nagatomo, E Morii, M Okumura
Cancer Sci., 2017;108(3):528-535.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

KIF5A transports collagen vesicles of myofibroblasts during pleural fibrosis
Authors: H Kamata, Y Tsukasaki, T Sakai, R Ikebe, J Wang, A Jeffers, J Boren, S Owens, T Suzuki, M Higashihar, S Idell, TA Tucker, M Ikebe
Sci Rep, 2017;7(1):4556.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The transcriptional coactivator TAZ regulates reciprocal differentiation of TH17 cells and Treg cells
Authors: J Geng, S Yu, H Zhao, X Sun, X Li, P Wang, X Xiong, L Hong, C Xie, J Gao, Y Shi, J Peng, RL Johnson, N Xiao, L Lu, J Han, D Zhou, L Chen
Nat. Immunol., 2017;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

CD73 promotes resistance to HER2/ErbB2 antibody therapy
Authors: M Turcotte, D Allard, D Mittal, Y Bareche, L Buisseret, V Jose, S Pommey, V Delisle, S Loi, H Joensuu, PL Kellokumpu, C Sotiriou, MJ Smyth, J Stagg
Cancer Res., 2017;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

TGF-? signaling directly regulates transcription and functional expression of the electrogenic sodium bicarbonate cotransporter 1, NBCe1 (SLC4A4), via Smad4 in mouse astrocytes
Authors: S Khakipoor, C Ophoven, M Schrödl-Hä, M Feuerstein, B Heimrich, JW Deitmer, E Roussa
Glia, 2017;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

PPAR? Links BMP2 and TGF?1 Pathways in Vascular Smooth Muscle Cells, Regulating Cell Proliferation and Glucose Metabolism
Authors: L Calvier, P Chouvarine, E Legchenko, N Hoffmann, J Geldner, P Borchert, D Jonigk, MM Mozes, G Hansmann
Cell Metab., 2017;25(5):1118-1134.e7.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

TGF beta-1 induced CD44v6-NOX4 signaling in pathogenesis of idiopathic pulmonary fibrosis
Authors: S Ghatak, VC Hascall, RR Markwald, C Feghali-Bo, CM Artlett, M Gooz, GS Bogatkevic, I Atanelishv, RM Silver, J Wood, VJ Thannickal, S Misra
J. Biol. Chem., 2017;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Activation of hepatic stellate cells by the ubiquitin C-terminal hydrolase 1 protein secreted from hepatitis C virus-infected hepatocytes
Authors: JC Cheng, CP Tseng, MH Liao, CY Peng, JS Yu, PH Chuang, JT Huang, JJW Chen
Sci Rep, 2017;7(1):4448.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Thymidylate synthase is functionally associated with ZEB1 and contributes to the epithelial-to-mesenchymal transition of cancer cells
Authors: A Siddiqui, ME Vazakidou, A Schwab, F Napoli, C Fernandez-, I Rapa, MP Stemmler, M Volante, T Brabletz, P Ceppi
J. Pathol, 2017;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Pro-invasive properties of Snail1 are regulated by sumoylation in response to TGF? stimulation in cancer.
Authors: Shyam Kumar Gudey, Reshma Sundar, Carl-Henrik Heldin, Anders Bergh, Marene Landström
Oncotarget, 2017;0(0):1949-2553.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Dual role of ALCAM in neuroinflammation and blood-brain barrier homeostasis
Authors: MA L‚cuyer, O Saint-Laur, L BourbonniŠ, S Larouche, C Larochelle, L Michel, M Charabati, M Abadier, S Zandee, N Haghayegh, E Gowing, C Pittet, R Lyck, B Engelhardt, A Prat
Proc. Natl. Acad. Sci. U.S.A, 2017;114(4):E524-E533.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Sex, pregnancy and aortic disease in Marfan syndrome
Authors: M Renard, L Muiño-Mosq, EC Manalo, S Tufa, EJ Carlson, DR Keene, J De Backer, LY Sakai
PLoS ONE, 2017;12(7):e0181166.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

FBXO32 promotes microenvironment underlying epithelial-mesenchymal transition via CtBP1 during tumour metastasis and brain development
Authors: SK Sahu, N Tiwari, A Pataskar, Y Zhuang, M Borisova, M Diken, S Strand, P Beli, VK Tiwari
Nat Commun, 2017;8(1):1523.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Periodontal tissue regeneration using the cytokine cocktail mimicking secretomes in the conditioned media from human mesenchymal stem cells
Authors: K Sakaguchi, W Katagiri, M Osugi, T Kawai, Y Sugimura-W, H Hibi
Biochem. Biophys. Res. Commun, 2017;484(1):100-106.
Species: Canine
Sample Types: Whole Cells
Applications: Bioassay

Increased levels of prostaglandin E-major urinary metabolite (PGE-MUM) in chronic fibrosing interstitial pneumonia
Authors: Tsugumi Horikiri
Respir Med, 2017;122(0):43-50.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The interplay of matrix metalloproteinase-8, transforming growth factor-?1 and vascular endothelial growth factor-C cooperatively contributes to the aggressiveness of oral tongue squamous cell carcinoma
Authors: P Åström, K Juurikka, ES Hadler-Ols, G Svineng, NK Cervigne, RD Coletta, J Risteli, JH Kauppila, S Skarp, S Kuttner, A Oteiza, M Sutinen, T Salo
Br. J. Cancer, 2017;117(7):1007-1016.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Epigenetically-Regulated MicroRNA-9-5p Suppresses the Activation of Hepatic Stellate Cells via TGFBR1 and TGFBR2
Authors: F Yu, B Chen, X Fan, G Li, P Dong, J Zheng
Cell. Physiol. Biochem., 2017;43(6):2242-2252.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Genomic reprograming analysis of the Mesothelial to Mesenchymal Transition identifies biomarkers in peritoneal dialysis patients
Authors: V Ruiz-Carpi, P Sandoval, A Aguilera, P Albar-Vizc, ML Perez-Loza, GT González-M, A Acuña-Ruiz, J García-Can, P Botías, MA Bajo, R Selgas, JA Sánchez-To, J Passlick-D, D Piecha, J Büchel, S Steppan, M López-Cabr
Sci Rep, 2017;7(0):44941.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Mutual interaction between endothelial cells and mural cells enhances BMP9 signaling in endothelial cells
Authors: Y Tachida, N Izumi, T Sakurai, H Kobayashi
Biol Open, 2017;6(3):370-380.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Lobeglitazone, a Novel Peroxisome Proliferator-Activated Receptor ? Agonist, Attenuates Renal Fibrosis Caused by Unilateral Ureteral Obstruction in Mice
Authors: KH Bae, JB Seo, YA Jung, HY Seo, SH Kang, HJ Jeon, JM Lee, S Lee, JG Kim, IK Lee, GS Jung, KG Park
Endocrinol Metab (Seoul), 2017;0(0):.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Podosome assembly is controlled by the GTPase ARF1 and its nucleotide exchange factor ARNO
Authors: Nisha Bte Mohd Rafiq
J. Cell Biol, 2017;216(1):181-197.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Platelet-Derived Growth Factor Receptor-Positive Pericytic Cells of White Adipose Tissue from Critical Limb Ischemia Patients Display Mesenchymal Stem Cell-Like Properties
Authors: EJ Kim, SG Seo, HS Shin, DJ Lee, JH Kim, DY Lee
Clin Orthop Surg, 2017;9(2):239-248.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Activation-induced cytidine deaminase targets SUV4-20-mediated histone H4K20 trimethylation to class-switch recombination sites
Authors: VC Rodríguez-, P Martínez-R, F Català-Mol, J Rodríguez-, A Garcia-Gom, G Poorani-Su, L Ciudad, H Hernando, A Pérez-Garc, C Company, JM Urquiza, AR Ramiro, JM Di Noia, A Vaquero, E Ballestar
Sci Rep, 2017;7(1):7594.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

GDF15 contributes to radioresistance and cancer stemness of head and neck cancer by regulating cellular reactive oxygen species via a SMAD-associated signaling pathway
Authors: YL Li, JT Chang, LY Lee, KH Fan, YC Lu, YC Li, CH Chiang, GR You, HY Chen, AJ Cheng
Oncotarget, 2017;8(1):1508-1528.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Chemical group-dependent plasma polymerisation preferentially directs adipose stem cell differentiation towards osteogenic or chondrogenic lineages
Authors: M F Griffin
Acta Biomater, 2016;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Interleukin-22 ameliorates liver fibrosis through miR-200a/beta-catenin
Sci Rep, 2016;6(0):36436.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Fscn1 is required for the trafficking of TGF-? family type I receptors during endoderm formation
Nat Commun, 2016;7(0):12603.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Immunotherapy against Metastatic Melanoma with Human iPS Cell-Derived Myeloid Cell Lines Producing Type I Interferons
Authors: A Miyashita, S Fukushima, S Nakahara, Y Kubo, A Tokuzumi, J Yamashita, J Aoi, M Haruta, S Senju, Y Nishimura, M Jinnin, H Ihn
Cancer Immunol Res, 2016;4(3):248-58.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A novel immunomodulatory function of neutrophils on rhinovirus-activated monocytes in vitro
Authors: Brian G Oliver
Thorax, 2016;71(11):1039-1049.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Context-Specific Function of S6K2 in Th Cell Differentiation
J Immunol, 2016;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Decellularized adipose tissue microcarriers as a dynamic culture platform for human adipose-derived stem/stromal cell expansion
Authors: Claire Yu
Biomaterials, 2016;120(0):66-80.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

MEG3 long noncoding RNA contributes to the epigenetic regulation of epithelial-mesenchymal transition in lung cancer cell lines
Authors: Takeshi Suzuki
J. Biol. Chem., 2016;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

MAP3K19 Is a Novel Regulator of TGF-? Signaling That Impacts Bleomycin-Induced Lung Injury and Pulmonary Fibrosis
PLoS ONE, 2016;11(5):e0154874.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Prion Protein Deficiency Causes Diverse Proteome Shifts in Cell Models That Escape Detection in Brain Tissue
Authors: Mohadeseh Mehrabian
PLoS ONE, 2016;11(6):e0156779.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Autonomous and Non-autonomous Defects Underlie Hypertrophic Cardiomyopathy in BRAF-Mutant hiPSC-Derived Cardiomyocytes
Stem Cell Reports, 2016;0(0):.
Species: Human
Sample Types: Protein
Applications: ELISA (Standard)

Clustering and jamming in epithelial-mesenchymal co-cultures
Authors: M Gamboa Cas, SE Leggett, IY Wong
Soft Matter, 2016;12(40):8327-8337.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Fibroblast Activation Protein (FAP) Accelerates Collagen Degradation and Clearance from Lungs in Mice
Authors: MH Fan, Q Zhu, HH Li, HJ Ra, S Majumdar, DL Gulick, JA Jerome, DH Madsen, M Christofid, DW Speicher, WW Bachovchin, C Feghali-Bo, E Puré
J. Biol. Chem., 2016;291(15):8070-89.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Senescent peritoneal mesothelium creates a niche for ovarian cancer metastases
Cell Death Dis, 2016;7(12):e2565.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Hepatitis C virus depends on E-cadherin as an entry factor and regulates its expression in epithelial-to-mesenchymal transition
Authors: Qisheng Li
Proc Natl Acad Sci USA, 2016;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Ablation of the N-type calcium channel ameliorates diabetic nephropathy with improved glycemic control and reduced blood pressure
Authors: Shoko Ohno
Sci Rep, 2016;6(0):27192.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The aryl hydrocarbon receptor controls cell-fate decisions in B cells
Authors: Bharat Vaidyanath
J. Exp. Med, 2016;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Altering the Proteoglycan State of Transforming Growth Factor ? Type III Receptor (T?RIII)/Betaglycan Modulates Canonical Wnt/?-Catenin Signaling
Authors: Karthikeyan Mythreye
J. Biol. Chem., 2016;291(49):25716-25728.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Transforming Growth Factor-? Limits Secretion of Lumican by Activated Stellate Cells within Primary Pancreatic Adenocarcinoma Tumors
Clin Cancer Res, 2016;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Two-Way Conversion between Lipogenic and Myogenic Fibroblastic Phenotypes Marks the Progression and Resolution of Lung Fibrosis
Authors: Saverio Bellusci
Cell Stem Cell, 2016;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Cell-cell contact and matrix adhesion promote ?SMA expression during TGF?1-induced epithelial-myofibroblast transition via Notch and MRTF-A
Sci Rep, 2016;6(0):26226.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

p(70S6K1) in the TORC1 pathway is essential for the differentiation of Th17 Cells, but not Th1, Th2, or Treg cells in mice.
Authors: Sasaki C, Chen G, Munk R, Eitan E, Martindale J, Longo D, Ghosh P
Eur J Immunol, 2016;46(1):212-22.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Noncanonical WNT-5A signaling impairs endogenous lung repair in COPD
Authors: Hoeke A Baarsma
J. Exp. Med, 2016;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

CD1c-Expression by Monocytes - Implications for the Use of Commercial CD1c+ Dendritic Cell Isolation Kits
Authors: Martine Schrøder
PLoS ONE, 2016;11(6):e0157387.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

CELF1 is a central node in post-transcriptional regulatory programmes underlying EMT
Nat Commun, 2016;7(0):13362.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

24R,25-Dihydroxyvitamin D3 Protects against Articular Cartilage Damage following Anterior Cruciate Ligament Transection in Male Rats
PLoS ONE, 2016;11(8):e0161782.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

IL-10 production in murine IgM(+) CD138(hi) cells is driven by Blimp1 and downregulated in class-switched cells
Eur. J. Immunol, 2016;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Targeted Rho-associated kinase 2 inhibition suppresses murine and human chronic GVHD through a Stat3-dependent mechanism
Authors: R Flynn, K Paz, J Du, DK Reichenbac, PA Taylor, A Panoskalts, A Vulic, L Luznik, KK MacDonald, GR Hill, MS Nyuydzefe, JM Weiss, W Chen, A Trzeciak, JS Serody, EG Aguilar, WJ Murphy, I Maillard, D Munn, J Koreth, CS Cutler, JH Antin, J Ritz, SD Waksal, A Zanin-Zhor, BR Blazar
Blood, 2016;127(17):2144-54.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Developmental Reprogramming in Mesenchymal Stromal Cells of Human Subjects with Idiopathic Pulmonary Fibrosis
Sci Rep, 2016;6(0):37445.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

TAR DNA-binding protein 43 inhibits inflammatory response and protects chondrocyte function by modulating RACK1 expression in osteoarthritis
Authors: Xiuyun Zeng
Biomed. Pharmacother., 2016;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Developing in vitro expanded CD45RA+ regulatory T cells as an adoptive cell therapy for Crohn's disease
Authors: James B Canavan
Gut, 2016;65(4):584-94.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

EZH2 enhances the differentiation of fibroblasts into myofibroblasts in idiopathic pulmonary fibrosis
Physiol Rep, 2016;4(17):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Loss of TRPV4 Function Suppresses Inflammatory Fibrosis Induced by Alkali-Burning Mouse Corneas
PLoS ONE, 2016;11(12):e0167200.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

TGF-?/ SMAD3 Pathway Stimulates Sphingosine-1-phosphate Receptor 3 Expression: Implication of Sphingosine-1-Phosphate Receptor 3 in Lung Adenocarcinoma Progression
Authors: Menq-Jer Lee
J. Biol. Chem., 2016;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Differentiation defect in neural crest-derived smooth muscle cells in patients with aortopathy associated with bicuspid aortic valves
EBioMedicine, 2016;10(0):282-90.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Patient-Specific Screening Using High-Grade Glioma Explants to Determine Potential Radiosensitization by a TGF-? Small Molecule Inhibitor
Neoplasia, 2016;18(12):795-805.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Regulatory T cells inhibit CD34+ cell differentiation into NK cells by blocking their proliferation.
Authors: Isabela Pedroza-Pa, Divya Shah, Anna Domogala, Martha Luevano, Michael Blundell, Nicola Jackson, Adrian Thrasher, Alejandro Madrigal, Aurore Saudemont
Scientific Reports, 2016;0(0):2045-2322.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Tissue factor induced by epithelial-mesenchymal transition triggers a pro-coagulant state that drives metastasis of circulating tumor cells
Cancer Res, 2016;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Kin17 facilitates multiple double-strand break repair pathways that govern B cell class switching
Sci Rep, 2016;6(0):37215.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Loss-of-Function Mutations in YY1AP1 Lead to Grange Syndrome and a Fibromuscular Dysplasia-Like Vascular Disease
Authors: Dong-Chuan Guo
Am. J. Hum. Genet, 2016;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Transient RUNX1 Expression during Early Mesendodermal Differentiation of�hESCs Promotes Epithelial to Mesenchymal Transition through TGFB2 Signaling
Stem Cell Reports, 2016;7(5):884-896.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Trichostatin A Inhibits Epithelial Mesenchymal Transition Induced by TGF-?1 in Airway Epithelium
PLoS ONE, 2016;11(8):e0162058.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci
Nat Commun, 2016;7(0):12092.

Ligase I and ligase III mediate the DNA double-strand break ligation in alternative end-joining.
Authors: Lu G, Duan J, Shu S, Wang X, Gao L, Guo J, Zhang Y
Proc Natl Acad Sci U S A, 2015;113(5):1256-60.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

JNK-dependent gene regulatory circuitry governs mesenchymal fate.
Authors: Sahu S, Garding A, Tiwari N, Thakurela S, Toedling J, Gebhard S, Ortega F, Schmarowski N, Berninger B, Nitsch R, Schmidt M, Tiwari V
EMBO J, 2015;34(16):2162-81.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

BMP9 Crosstalk with the Hippo Pathway Regulates Endothelial Cell Matricellular and Chemokine Responses.
Authors: Young K, Tweedie E, Conley B, Ames J, FitzSimons M, Brooks P, Liaw L, Vary C
PLoS ONE, 2015;10(4):e0122892.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Reciprocal cellular cross-talk within the tumor microenvironment promotes oncolytic virus activity.
Authors: Ilkow C, Marguerie M, Batenchuk C, Mayer J, Ben Neriah D, Cousineau S, Falls T, Jennings V, Boileau M, Bellamy D, Bastin D, de Souza C, Alkayyal A, Zhang J, Le Boeuf F, Arulanandam R, Stubbert L, Sampath P, Thorne S, Paramanthan P, Chatterjee A, Strieter R, Burdick M, Addison C, Stojdl D, Atkins H, Auer R, Diallo J, Lichty B, Bell J
Nat Med, 2015;21(5):530-6.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Mitochondrial SOD2 regulates epithelial-mesenchymal transition and cell populations defined by differential CD44 expression.
Authors: Kinugasa H, Whelan K, Tanaka K, Natsuizaka M, Long A, Guo A, Chang S, Kagawa S, Srinivasan S, Guha M, Yamamoto K, St Clair D, Avadhani N, Diehl J, Nakagawa H
Oncogene, 2015;34(41):5229-39.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The PAX3-FOXO1 fusion protein present in rhabdomyosarcoma interferes with normal FOXO activity and the TGF-beta pathway.
Authors: Schmitt-Ney M, Camussi G
PLoS ONE, 2015;10(3):e0121474.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The Prion Protein Controls Polysialylation of Neural Cell Adhesion Molecule 1 during Cellular Morphogenesis.
Authors: Mehrabian M, Brethour D, Wang H, Xi Z, Rogaeva E, Schmitt-Ulms G
PLoS ONE, 2015;10(8):e0133741.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Drak2 Does Not Regulate TGF-beta Signaling in T Cells.
Authors: Harris T, McGargill M
PLoS ONE, 2015;10(5):e0123650.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Effects of sodium citrate and acid citrate dextrose solutions on cell counts and growth factor release from equine pure-platelet rich plasma and pure-platelet rich gel.
Authors: Giraldo C, Alvarez M, Carmona J
BMC Vet Res, 2015;11(0):60.
Species: Equine
Sample Types: Plasma

Novel mechanism of macrophage-mediated metastasis revealed in a zebrafish model of tumor development.
Authors: Wang J, Cao Z, Zhang X, Nakamura M, Sun M, Hartman J, Harris R, Sun Y, Cao Y
Cancer Res, 2015;75(2):306-15.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Lipoxin A4 Attenuates Constitutive and TGF-beta1-Dependent Profibrotic Activity in Human Lung Myofibroblasts.
Authors: Roach K, Feghali-Bostwick C, Amrani Y, Bradding P
J Immunol, 2015;195(6):2852-60.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Novel and optimized strategies for inducing fibrosis in vivo: focus on Duchenne Muscular Dystrophy.
Authors: Pessina P, Cabrera D, Morales M, Riquelme C, Gutierrez J, Serrano A, Brandan E, Munoz-Canoves P
Skelet Muscle, 2015;4(0):7.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Long-term expansion, enhanced chondrogenic potential, and suppression of endochondral ossification of adult human MSCs via WNT signaling modulation.
Authors: Narcisi R, Cleary M, Brama P, Hoogduijn M, Tuysuz N, ten Berge D, van Osch G
Stem Cell Reports, 2015;4(3):459-72.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Role of a Novel Human Leukocyte Antigen-DQA1*01:02;DRB1*15:01 Mixed Isotype Heterodimer in the Pathogenesis of "Humanized" Multiple Sclerosis-like Disease.
Authors: Kaushansky N, Eisenstein M, Boura-Halfon S, Hansen B, Nielsen C, Milo R, Zeilig G, Lassmann H, Altmann D, Ben-Nun A
J Biol Chem, 2015;290(24):15260-78.
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: ELISA (Standard)

Role and species-specific expression of colon T cell homing receptor GPR15 in colitis.
Authors: Nguyen L, Pan J, Dinh T, Hadeiba H, O'Hara E, Ebtikar A, Hertweck A, Gokmen M, Lord G, Jenner R, Butcher E, Habtezion A
Nat Immunol, 2015;16(2):207-13.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

MiR-133 modulates TGF-β1-induced bladder smooth muscle cell hypertrophic and fibrotic response: implication for a role of microRNA in bladder wall remodeling caused by bladder outlet obstruction.
Cell Signal, 2015;27(2):215-27.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Cutting edge: epigenetic regulation of Foxp3 defines a stable population of CD4+ regulatory T cells in tumors from mice and humans.
Authors: Waight J, Takai S, Marelli B, Qin G, Hance K, Zhang D, Tighe R, Lan Y, Lo K, Sabzevari H, Hofmeister R, Wilson N
J Immunol, 2015;194(3):878-82.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Pyrroloquinoline-quinone suppresses liver fibrogenesis in mice.
Authors: Jia D, Duan F, Peng P, Sun L, Ruan Y, Gu J
PLoS ONE, 2015;10(3):e0121939.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

TGFbeta-induced phosphorylation of Par6 promotes migration and invasion in prostate cancer cells.
Authors: Mu Y, Zang G, Engstrom U, Busch C, Landstrom M
Br J Cancer, 2015;112(7):1223-31.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

5Z-7-Oxozeanol Inhibits the Effects of TGFbeta1 on Human Gingival Fibroblasts.
Authors: Kuk H, Hutchenreuther J, Murphy-Marshman H, Carter D, Leask A
PLoS ONE, 2015;10(4):e0123689.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

CXCL13 antibody for the treatment of autoimmune disorders.
Authors: Klimatcheva E, Pandina T, Reilly C, Torno S, Bussler H, Scrivens M, Jonason A, Mallow C, Doherty M, Paris M, Smith E, Zauderer M
BMC Immunol, 2015;16(0):6.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Human natural killer cell microRNA: differential expression of MIR181A1B1 and MIR181A2B2 genes encoding identical mature microRNAs.
Authors: Presnell S, Al-Attar A, Cichocki F, Miller J, Lutz C
Genes Immun, 2015;16(1):89-98.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Inhibition of T-cell activation by retinal pigment epithelial cells derived from induced pluripotent stem cells.
Authors: Sugita S, Kamao H, Iwasaki Y, Okamoto S, Hashiguchi T, Iseki K, Hayashi N, Mandai M, Takahashi M
Invest Ophthalmol Vis Sci, 2015;56(2):1051-62.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Breast cancer cells promote a notch-dependent mesenchymal phenotype in endothelial cells participating to a pro-tumoral niche.
Authors: Ghiabi P, Jiang J, Pasquier J, Maleki M, Abu-Kaoud N, Halabi N, Guerrouahen B, Rafii S, Rafii A
J Transl Med, 2015;13(0):27.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Redundant function of DNA ligase 1 and 3 in alternative end-joining during immunoglobulin class switch recombination.
Authors: Masani S, Han L, Meek K, Yu K
Proc Natl Acad Sci U S A, 2015;113(5):1261-6.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

4-1BB ligand signaling to T cells limits T cell activation.
Authors: Eun S, Lee S, Xu Y, Croft M
J Immunol, 2015;194(1):134-41.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

TGF-beta1-induced EMT promotes targeted migration of breast cancer cells through the lymphatic system by the activation of CCR7/CCL21-mediated chemotaxis.
Authors: Pang M, Georgoudaki A, Lambut L, Johansson J, Tabor V, Hagikura K, Jin Y, Jansson M, Alexander J, Nelson C, Jakobsson L, Betsholtz C, Sund M, Karlsson M, Fuxe J
Oncogene, 2015;35(6):748-60.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Mesenchymal stem cells from patients with rheumatoid arthritis display impaired function in inhibiting Th17 cells.
Authors: Sun, Yue, Deng, Wei, Geng, Linyu, Zhang, Lu, Liu, Rui, Chen, Weiwei, Yao, Genhong, Zhang, Huayong, Feng, Xuebing, Gao, Xiang, Sun, Lingyun
J Immunol Res, 2015;2015(0):284215.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

High mobility group protein-mediated transcription requires DNA damage marker gamma-H2AX.
Authors: Singh I, Ozturk N, Cordero J, Mehta A, Hasan D, Cosentino C, Sebastian C, Kruger M, Looso M, Carraro G, Bellusci S, Seeger W, Braun T, Mostoslavsky R, Barreto G
Cell Res, 2015;25(7):837-50.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Radiation-induced alterations of osteogenic and chondrogenic differentiation of human mesenchymal stem cells.
Authors: Cruet-Hennequart S, Drougard C, Shaw G, Legendre F, Demoor M, Barry F, Lefaix J, Galera P
PLoS ONE, 2015;10(3):e0119334.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Identification and Characterization of CXCR4-Positive Gastric Cancer Stem Cells.
Authors: Fujita T, Chiwaki F, Takahashi R, Aoyagi K, Yanagihara K, Nishimura T, Tamaoki M, Komatsu M, Komatsuzaki R, Matsusaki K, Ichikawa H, Sakamoto H, Yamada Y, Fukagawa T, Katai H, Konno H, Ochiya T, Yoshida T, Sasaki H
PLoS ONE, 2015;10(6):e0130808.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Salinomycin and other polyether ionophores are a new class of antiscarring agent.
Authors: Woeller C, O'Loughlin C, Roztocil E, Feldon S, Phipps R
J Biol Chem, 2015;290(6):3563-75.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The anti-fibrotic effects of epigallocatechin-3-gallate in bile duct-ligated cholestatic rats and human hepatic stellate LX-2 cells are mediated by the PI3K/Akt/Smad pathway.
Authors: Yu D, Zhang C, Zhao S, Zhang S, Zhang H, Cai S, Shao R, He H
Acta Pharmacol Sin, 2015;36(4):473-82.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Suppressor of cytokine signaling 1 is a positive regulator of TGF-beta-induced prostaglandin production in human follicular dendritic cell-like cells.
Authors: Cho W, Kim Y, Kim J, Park S, Park D, Kim B, Jeoung D, Kim Y, Choe J
J Immunol, 2015;194(9):4287-97.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Rapid generation of endogenously driven transcriptional reporters in cells through CRISPR/Cas9.
Authors: Rojas-Fernandez A, Herhaus L, Macartney T, Lachaud C, Hay R, Sapkota G
Sci Rep, 2015;5(0):9811.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Snai1 promotes ESC exit from the pluripotency by direct repression of self-renewal genes.
Authors: Galvagni F, Lentucci C, Neri F, Dettori D, De Clemente C, Orlandini M, Anselmi F, Rapelli S, Grillo M, Borghi S, Oliviero S
Stem Cells, 2015;33(3):742-50.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

The DNA-binding inhibitor Id3 regulates IL-9 production in CD4(+) T cells.
Authors: Nakatsukasa H, Zhang D, Maruyama T, Chen H, Cui K, Ishikawa M, Deng L, Zanvit P, Tu E, Jin W, Abbatiello B, Goldberg N, Chen Q, Sun L, Zhao K, Chen W
Nat Immunol, 2015;16(10):1077-84.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Serum induces transcription of Hey1 and Hey2 genes by Alk1 but not Notch signaling in endothelial cells.
Authors: Woltje K, Jabs M, Fischer A
PLoS ONE, 2015;10(3):e0120547.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Dietary n-3 PUFA Protects Mice from Con A Induced Liver Injury by Modulating Regulatory T Cells and PPAR-gamma Expression.
Authors: Lian M, Luo W, Sui Y, Li Z, Hua J
PLoS ONE, 2015;10(7):e0132741.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells.
Authors: Rutz S, Kayagaki N, Phung Q, Eidenschenk C, Noubade R, Wang X, Lesch J, Lu R, Newton K, Huang O, Cochran A, Vasser M, Fauber B, DeVoss J, Webster J, Diehl L, Modrusan Z, Kirkpatrick D, Lill J, Ouyang W, Dixit V
Nature, 2015;518(7539):417-21.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Wilms' tumor 1 (Wt1) regulates pleural mesothelial cell plasticity and transition into myofibroblasts in idiopathic pulmonary fibrosis.
Authors: Karki S, Surolia R, Hock T, Guroji P, Zolak J, Duggal R, Ye T, Thannickal V, Antony V
FASEB J, 2014;28(3):1122-31.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

TGF-beta/Smad3 stimulates stem cell/developmental gene expression and vascular smooth muscle cell de-differentiation.
Authors: Shi X, DiRenzo D, Guo L, Franco S, Wang B, Seedial S, Kent K
, 2014;9(0):.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Characteristics of TCR/CD3 complex CD3{varepsilon} chains of regulatory CD4+ T (Treg) lymphocytes: role in Treg differentiation in vitro and impact on Treg in vivo.
Authors: Rojo J, Ojeda G, Acosta Y, Montes-Casado M, Criado G, Portoles P
J Leukoc Biol, 2014;95(3):441-50.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Curcumin up-regulates phosphatase and tensin homologue deleted on chromosome 10 through microRNA-mediated control of DNA methylation--a novel mechanism suppressing liver fibrosis.
Authors: Zheng J, Wu C, Lin Z, Guo Y, Shi L, Dong P, Lu Z, Gao S, Liao Y, Chen B, Yu F
FEBS J, 2014;281(1):88-103.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Biochemical and structural characterization of neocartilage formed by mesenchymal stem cells in alginate hydrogels.
Authors: Olderoy M, Lilledahl M, Beckwith M, Melvik J, Reinholt F, Sikorski P, Brinchmann J
PLoS ONE, 2014;9(3):e91662.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Angiotensin II-dependent TGF-beta signaling contributes to Loeys-Dietz syndrome vascular pathogenesis.
Authors: Gallo E, Loch D, Habashi J, Calderon J, Chen Y, Bedja D, van Erp C, Gerber E, Parker S, Sauls K, Judge D, Cooke S, Lindsay M, Rouf R, Myers L, ap Rhys C, Kent K, Norris R, Huso D, Dietz H
J Clin Invest, 2014;124(1):448-60.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Telomerase governs immunomodulatory properties of mesenchymal stem cells by regulating FAS ligand expression.
Authors: Chen C, Akiyama K, Yamaza T, You Y, Xu X, Li B, Zhao Y, Shi S
EMBO Mol Med, 2014;6(3):322-34.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Phospholipase D1 mediates lymphocyte adhesion and migration in experimental autoimmune encephalomyelitis.
Authors: Gobel K, Schuhmann M, Pankratz S, Stegner D, Herrmann A, Braun A, Breuer J, Bittner S, Ruck T, Wiendl H, Kleinschnitz C, Nieswandt B, Meuth S
Eur J Immunol, 2014;44(8):2295-305.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

The broad-spectrum metalloproteinase inhibitor BB-94 inhibits growth, HER3 and Erk activation in fulvestrant-resistant breast cancer cell lines.
Authors: Kirkegaard T, Yde C, Kveiborg M, Lykkesfeldt A
Int J Oncol, 2014;45(1):393-400.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Epithelial splicing regulatory protein 1 is a favorable prognostic factor in pancreatic cancer that attenuates pancreatic metastases.
Authors: Ueda J, Matsuda Y, Yamahatsu K, Uchida E, Naito Z, Korc M, Ishiwata T
Oncogene, 2014;33(36):4485-95.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Inhibitory effects of PPARgamma ligands on TGF-beta1-induced corneal myofibroblast transformation.
Authors: Jeon K, Kulkarni A, Woeller C, Phipps R, Sime P, Hindman H, Huxlin K
Am J Pathol, 2014;184(5):1429-45.
Species: Feline
Sample Types: Whole Cells
Applications: Bioassay

Negative regulation of NADPH oxidase 4 by hydrogen peroxide-inducible clone 5 (Hic-5) protein.
Authors: Desai L, Zhou Y, Estrada A, Ding Q, Cheng G, Collawn J, Thannickal V
J Biol Chem, 2014;289(26):18270-8.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Interleukin 7 plays a role in T lymphocyte apoptosis inhibition driven by mesenchymal stem cell without favoring proliferation and cytokines secretion.
Authors: Normanton M, Alvarenga H, Hamerschlak N, Ribeiro A, Kondo A, Rizzo L, Marti L
PLoS ONE, 2014;9(9):e106673.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Gene expression profiles of human adipose tissue-derived mesenchymal stem cells are modified by cell culture density.
Authors: Kim D, Lee M, Yoo K, Lee T, Kim H, Jang I, Chun Y, Kim H, Park S, Lee S, Son M, Jung H, Sung K, Koo H
PLoS ONE, 2014;9(1):e83363.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Coronary heart disease-associated variation in TCF21 disrupts a miR-224 binding site and miRNA-mediated regulation.
Authors: Miller C, Haas U, Diaz R, Leeper N, Kundu R, Patlolla B, Assimes T, Kaiser F, Perisic L, Hedin U, Maegdefessel L, Schunkert H, Erdmann J, Quertermous T, Sczakiel G
PLoS Genet, 2014;10(3):e1004263.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Inhibition of periostin expression protects against the development of renal inflammation and fibrosis.
Authors: Mael-Ainin M, Abed A, Conway S, Dussaule J, Chatziantoniou C
J Am Soc Nephrol, 2014;25(8):1724-36.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Protein tyrosine phosphatase alpha mediates profibrotic signaling in lung fibroblasts through TGF-beta responsiveness.
Authors: Aschner Y, Khalifah A, Briones N, Yamashita C, Dolgonos L, Young S, Campbell M, Riches D, Redente E, Janssen W, Henson P, Sap J, Vacaresse N, Kapus A, McCulloch C, Zemans R, Downey G
Am J Pathol, 2014;184(5):1489-502.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Influenza promotes collagen deposition via alphavbeta6 integrin-mediated transforming growth factor beta activation.
Authors: Jolly L, Stavrou A, Vanderstoken G, Meliopoulos V, Habgood A, Tatler A, Porte J, Knox A, Weinreb P, Violette S, Hussell T, Kolb M, Stampfli M, Schultz-Cherry S, Jenkins G
J Biol Chem, 2014;289(51):35246-63.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Differentiation of IL-17-producing effector and regulatory human T cells from lineage-committed naive precursors.
Authors: Mercer F, Khaitan A, Kozhaya L, Aberg J, Unutmaz D
J Immunol, 2014;193(3):1047-54.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

COL11A1 promotes tumor progression and predicts poor clinical outcome in ovarian cancer.
Authors: Wu Y, Chang T, Huang Y, Huang H, Chou C
Oncogene, 2014;33(26):3432-40.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Binding of AID to DNA does not correlate with mutator activity.
Authors: Matthews A, Husain S, Chaudhuri J
J Immunol, 2014;193(1):252-7.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Induction of immunoregulatory CD271+ cells by metastatic tumor cells that express human endogenous retrovirus H.
Authors: Kudo-Saito C, Yura M, Yamamoto R, Kawakami Y
Cancer Res, 2014;74(5):1361-70.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

JAK/STAT3 signaling is required for TGF-beta-induced epithelial-mesenchymal transition in lung cancer cells.
Authors: Liu R, Zeng Y, Lei Z, Wang L, Yang H, Liu Z, Zhao J, Zhang H
Int J Oncol, 2014;44(5):1643-51.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

B7-H1-expressing antigen-presenting cells mediate polarization of protumorigenic Th22 subsets.
Authors: Kuang D, Xiao X, Zhao Q, Chen M, Li X, Liu R, Wei Y, Ouyang F, Chen D, Wu Y, Lao X, Deng H, Zheng L
J Clin Invest, 2014;124(10):4657-67.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Transforming growth factor beta signaling overcomes dasatinib resistance in lung cancer.
Authors: Gordian E, Li J, Pevzner Y, Mediavilla-Varela M, Luddy K, Ohaegbulam K, Daniel K, Haura E, Munoz-Antonia T
PLoS ONE, 2014;9(12):e114131.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

MicroRNA-7 inhibition rescues age-associated loss of epidermal growth factor receptor and hyaluronan-dependent differentiation in fibroblasts.
Authors: Midgley A, Bowen T, Phillips A, Steadman R
Aging Cell, 2014;13(2):235-44.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Musashi-2 controls cell fate, lineage bias, and TGF-beta signaling in HSCs.
Authors: Park S, Deering R, Lu Y, Tivnan P, Lianoglou S, Al-Shahrour F, Ebert B, Hacohen N, Leslie C, Daley G, Lengner C, Kharas M
J Exp Med, 2014;211(1):71-87.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Secreted fibroblast-derived miR-34a induces tubular cell apoptosis in fibrotic kidney.
Authors: Zhou Y, Xiong M, Niu J, Sun Q, Su W, Zen K, Dai C, Yang J
J Cell Sci, 2014;127(0):4494-506.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Dual role of acetaminophen in promoting hepatoma cell apoptosis and kidney fibroblast proliferation.
Authors: Yu Y, Yiang G, Chou P, Tseng H, Wu T, Hung Y, Lin P, Lin S, Liu H, Chang W, Wei C
Mol Med Rep, 2014;9(6):2077-84.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Transcriptomic profiling of the development of the inflammatory response in human monocytes in vitro.
Authors: Italiani, Paola, Mazza, Emilia M, Lucchesi, Davide, Cifola, Ingrid, Gemelli, Claudia, Grande, Alexis, Battaglia, Cristina, Bicciato, Silvio, Boraschi, Diana
PLoS ONE, 2014;9(2):e87680.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Independent adipogenic and contractile properties of fibroblasts in Graves' orbitopathy: an in vitro model for the evaluation of treatments.
Authors: Li H, Fitchett C, Kozdon K, Jayaram H, Rose G, Bailly M, Ezra D
PLoS ONE, 2014;9(4):e95586.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

TRPA1 is required for TGF-beta signaling and its loss blocks inflammatory fibrosis in mouse corneal stroma.
Authors: Okada Y, Shirai K, Reinach P, Kitano-Izutani A, Miyajima M, Flanders K, Jester J, Tominaga M, Saika S
Lab Invest, 2014;94(9):1030-41.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Glucocorticoids recruit Tgfbr3 and Smad1 to shift transforming growth factor-beta signaling from the Tgfbr1/Smad2/3 axis to the Acvrl1/Smad1 axis in lung fibroblasts.
Authors: Schwartze J, Becker S, Sakkas E, Wujak L, Niess G, Usemann J, Reichenberger F, Herold S, Vadasz I, Mayer K, Seeger W, Morty R
J Biol Chem, 2014;289(6):3262-75.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Staphylococcal nuclease domain containing-1 (SND1) promotes migration and invasion via angiotensin II type 1 receptor (AT1R) and TGFbeta signaling.
Authors: Santhekadur P, Akiel M, Emdad L, Gredler R, Srivastava J, Rajasekaran D, Robertson C, Mukhopadhyay N, Fisher P, Sarkar D
FEBS Open Bio, 2014;4(0):353-61.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Synthetic triterpenoid induces 15-PGDH expression and suppresses inflammation-driven colon carcinogenesis.
Authors: Choi S, Kim B, Robinson J, Fink S, Yan M, Sporn M, Markowitz S, Letterio J
J Clin Invest, 2014;124(6):2472-82.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Trim28 contributes to EMT via regulation of E-cadherin and N-cadherin in lung cancer cell lines.
Authors: Chen L, Munoz-Antonia T, Cress W
PLoS ONE, 2014;9(7):e101040.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The aryl hydrocarbon receptor is functionally upregulated early in the course ofvhuman T-cell activation.
Authors: Prigent L, Robineau M, Jouneau S, Morzadec C, Louarn L, Vernhet L, Fardel O, Sparfel L
Eur J Immunol, 2014;44(5):1330-40.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

c-Jun N terminal kinase modulates NOX-4 derived ROS production and myofibroblasts differentiation in human breast stromal cells.
Authors: Tobar N, Toyos M, Urra C, Mendez N, Arancibia R, Smith P, Martinez J
BMC Cancer, 2014;14(0):640.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Expression of insulin-like growth factor 2 receptor in corneal keratocytes during differentiation and in response to wound healing.
Authors: Bohnsack R, Warejcka D, Wang L, Gillespie S, Bernstein A, Twining S, Dahms N
Invest Ophthalmol Vis Sci, 2014;55(12):7697-708.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Vitamin D up-regulates the vitamin D receptor by protecting it from proteasomal degradation in human CD4+ T cells.
Authors: Kongsbak M, von Essen M, Boding L, Levring T, Schjerling P, Lauritsen J, Woetmann A, Odum N, Bonefeld C, Geisler C
PLoS ONE, 2014;9(5):e96695.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis.
Authors: Komatsu N, Okamoto K, Sawa S, Nakashima T, Oh-hora M, Kodama T, Tanaka S, Bluestone J, Takayanagi H
Nat Med, 2014;20(1):62-8.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

MicroRNA-224 is involved in the regulation of mouse cumulus expansion by targeting Ptx3.
Authors: Yao G, Liang M, Liang N, Yin M, Lu M, Lian J, Wang Y, Sun F
Mol Cell Endocrinol, 2014;382(1):244-53.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells.
Authors: Kofler D, Marson A, Dominguez-Villar M, Xiao S, Kuchroo V, Hafler D
J Clin Invest, 2014;124(6):2513-22.
Species: Human
Sample Types: Whole Cells

TGF-beta-activated kinase 1 (TAK1) signaling regulates TGF-beta-induced WNT-5A expression in airway smooth muscle cells via Sp1 and beta-catenin.
Authors: Kumawat K, Menzen M, Slegtenhorst R, Halayko A, Schmidt M, Gosens R
PLoS ONE, 2014;9(4):e94801.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Homozygous deletion of the activin A receptor, type IB gene is associated with an aggressive cancer phenotype in pancreatic cancer.
Authors: Togashi, Yosuke, Sakamoto, Hiroki, Hayashi, Hidetosh, Terashima, Masato, de Velasco, Marco A, Fujita, Yoshihik, Kodera, Yasuo, Sakai, Kazuko, Tomida, Shuta, Kitano, Masayuki, Ito, Akihiko, Kudo, Masatosh, Nishio, Kazuto
Mol Cancer, 2014;13(0):126.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

CD4+CD25+ T regulatory cells activated during feline immunodeficiency virus infection convert T helper cells into functional suppressors through a membrane-bound TGFbeta / GARP-mediated mechanism.
Authors: Miller M, Petty C, Tompkins M, Fogle J
Virol J, 2014;11(0):7.
Species: Feline
Sample Types: Whole Cells
Applications: Bioassay

The fate of the primary cilium during myofibroblast transition.
Authors: Rozycki M, Lodyga M, Lam J, Miranda M, Fatyol K, Speight P, Kapus A
Mol Biol Cell, 2014;25(5):643-57.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

TGFbeta-mediated suppression of CD248 in non-cancer cells via canonical Smad-dependent signaling pathways is uncoupled in cancer cells.
Authors: Suresh Babu S, Valdez Y, Xu A, O'Byrne A, Calvo F, Lei V, Conway E
BMC Cancer, 2014;14(0):113.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Role of leukocyte cell-derived chemotaxin 2 as a biomarker in hepatocellular carcinoma.
Authors: Okabe H, Delgado E, Lee J, Yang J, Kinoshita H, Hayashi H, Tsung A, Behari J, Beppu T, Baba H, Monga S
PLoS ONE, 2014;9(6):e98817.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Restoration of muscle strength in dystrophic muscle by angiotensin-1-7 through inhibition of TGF-beta signalling.
Authors: Acuna M, Pessina P, Olguin H, Cabrera D, Vio C, Bader M, Munoz-Canoves P, Santos R, Cabello-Verrugio C, Brandan E
Hum Mol Genet, 2014;23(5):1237-49.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Effective chemoimmunotherapy with anti-TGFbeta antibody and cyclophosphamide in a mouse model of breast cancer.
Authors: Chen X, Yang Y, Zhou Q, Weiss J, Howard O, McPherson J, Wakefield L, Oppenheim J
PLoS ONE, 2014;9(1):e85398.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Histone deacetylase inhibitor romidepsin induces HIV expression in CD4 T cells from patients on suppressive antiretroviral therapy at concentrations achieved by clinical dosing.
Authors: Wei D, Chiang V, Fyne E, Balakrishnan M, Barnes T, Graupe M, Hesselgesser J, Irrinki A, Murry J, Stepan G, Stray K, Tsai A, Yu H, Spindler J, Kearney M, Spina C, McMahon D, Lalezari J, Sloan D, Mellors J, Geleziunas R, Cihlar T
PLoS Pathog, 2014;10(4):e1004071.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Systemic sclerosis immunoglobulin induces growth and a pro-fibrotic state in vascular smooth muscle cells through the epidermal growth factor receptor.
Authors: Arts M, Baron M, Chokr N, Fritzler M, Servant M
PLoS ONE, 2014;9(6):e100035.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Control of a tumor suppressor PDCD4: Degradation mechanisms of the protein in hepatocellular carcinoma cells.
Authors: Matsuhashi S, Hamajima H, Xia J, Zhang H, Mizuta T, Anzai K, Ozaki I
Cell Signal, 2014;26(3):603-10.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The roles of the epithelial-mesenchymal transition marker PRRX1 and miR-146b-5p in papillary thyroid carcinoma progression.
Authors: Hardin H, Guo Z, Shan W, Montemayor-Garcia C, Asioli S, Yu X, Harrison A, Chen H, Lloyd R
Am J Pathol, 2014;184(8):2342-54.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Human chondrocytes respond discordantly to the protein encoded by the osteoarthritis susceptibility gene GDF5.
Authors: Ratnayake M, Ploger F, Santibanez-Koref M, Loughlin J
PLoS ONE, 2014;9(1):e86590.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Tead2 expression levels control the subcellular distribution of Yap and Taz, zyxin expression and epithelial-mesenchymal transition.
Authors: Diepenbruck, Maren, Waldmeier, Lorenz, Ivanek, Robert, Berninger, Philipp, Arnold, Phil, van Nimwegen, Erik, Christofori, Gerhard
J Cell Sci, 2014;127(0):1523-36.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

A signal transduction pathway from TGF-beta1 to SKP2 via Akt1 and c-Myc and its correlation with progression in human melanoma.
Authors: Qu X, Shen L, Zheng Y, Cui Y, Feng Z, Liu F, Liu J
J Invest Dermatol, 2014;134(1):159-67.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Chromatinized protein kinase C-theta directly regulates inducible genes in epithelial to mesenchymal transition and breast cancer stem cells.
Authors: Zafar A, Wu F, Hardy K, Li J, Tu W, McCuaig R, Harris J, Khanna K, Attema J, Gregory P, Goodall G, Harrington K, Dahlstrom J, Boulding T, Madden R, Tan A, Milburn P, Rao S
Mol Cell Biol, 2014;34(16):2961-80.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Transcriptional regulation of seprase in invasive melanoma cells by transforming growth factor-beta signaling.
Authors: Tulley S, Chen W
J Biol Chem, 2014;289(22):15280-96.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Follicular dendritic cell secreted protein FDC-SP controls IgA production.
Authors: Hou S, Landego I, Jayachandran N, Miller A, Gibson I, Ambrose C, Marshall A
Mucosal Immunol, 2014;7(4):948-57.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Redox control of p53 in the transcriptional regulation of TGF-beta1 target genes through SMAD cooperativity.
Authors: Overstreet J, Samarakoon R, Meldrum K, Higgins P
Cell Signal, 2014;26(7):1427-36.

Inhibition by all-trans-retinoic acid of transforming growth factor-beta-induced collagen gel contraction mediated by human tenon fibroblasts.
Authors: Liu Y, Kimura K, Orita T, Teranishi S, Suzuki K, Sonoda K
Invest Ophthalmol Vis Sci, 2014;55(7):4199-205.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

VDR activity is differentially affected by Hic-5 in prostate cancer and stromal cells.
Authors: Solomon J, Heitzer M, Liu T, Beumer J, Parise R, Normolle D, Leach D, Buchanan G, DeFranco D
Mol Cancer Res, 2014;12(8):1166-80.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Induction of galectin-1 by TGF-beta1 accelerates fibrosis through enhancing nuclear retention of Smad2.
Authors: Lim M, Ahn J, Yi J, Kim M, Son A, Lee S, Lim D, Kim S, Kang M, Han Y, Song J
Exp Cell Res, 2014;326(1):125-35.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Detection of atomic scale changes in the free volume void size of three-dimensional colorectal cancer cell culture using positron annihilation lifetime spectroscopy.
Authors: Axpe E, Lopez-Euba T, Castellanos-Rubio A, Merida D, Garcia J, Plaza-Izurieta L, Fernandez-Jimenez N, Plazaola F, Bilbao J
PLoS ONE, 2014;9(1):e83838.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The anti-proliferative function of the TGF-beta1 signaling pathway involves the repression of the oncogenic TBX2 by its homologue TBX3.
Authors: Li J, Ballim D, Rodriguez M, Cui R, Goding C, Teng H, Prince S
J Biol Chem, 2014;289(51):35633-43.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Bone morphogenetic protein signaling protects against cerulein-induced pancreatic fibrosis.
Authors: Gao X, Cao Y, Staloch D, Gonzales M, Aronson J, Chao C, Hellmich M, Ko T
PLoS ONE, 2014;9(2):e89114.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Human fetal and adult bone marrow-derived mesenchymal stem cells use different signaling pathways for the initiation of chondrogenesis.
Authors: Brady K, Dickinson S, Guillot P, Polak J, Blom A, Kafienah W, Hollander A
Stem Cells Dev, 2014;23(5):541-54.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Role of Blimp-1 in programing Th effector cells into IL-10 producers.
Authors: Neumann C, Heinrich F, Neumann K, Junghans V, Mashreghi M, Ahlers J, Janke M, Rudolph C, Mockel-Tenbrinck N, Kuhl A, Heimesaat M, Esser C, Im S, Radbruch A, Rutz S, Scheffold A
J Exp Med, 2014;211(9):1807-19.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Loss of Dab2 expression in breast cancer cells impairs their ability to deplete TGF-beta and induce Tregs development via TGF-beta.
Authors: Xu S, Zhu J, Wu Z
PLoS ONE, 2014;9(3):e91709.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Caffeine and rolipram affect Smad signalling and TGF-beta1 stimulated CTGF and transgelin expression in lung epithelial cells.
Authors: Fehrholz M, Speer C, Kunzmann S
PLoS ONE, 2014;9(5):e97357.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The AMPK agonist AICAR inhibits TGF-beta1 induced activation of kidney myofibroblasts.
Authors: Chen K, Hsu H, Lee C, Yen T, Ko Y, Yang C, Hung C
PLoS ONE, 2014;9(9):e106554.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Combined targeting of TGF-beta1 and integrin beta3 impairs lymph node metastasis in a mouse model of non-small-cell lung cancer.
Authors: Salvo E, Garasa S, Dotor J, Morales X, Pelaez R, Altevogt P, Rouzaut A
Mol Cancer, 2014;13(0):112.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Midkine-deficiency delays chondrogenesis during the early phase of fracture healing in mice.
Authors: Haffner-Luntzer, Melanie, Heilmann, Aline, Rapp, Anna Eli, Beie, Simon, Schinke, Thorsten, Amling, Michael, Ignatius, Anita, Liedert, Astrid
PLoS ONE, 2014;9(12):e116282.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Src-mediated post-translational regulation of endoglin stability and function is critical for angiogenesis.
Authors: Pan C, Kumar S, Shah N, Hoyt D, Hawinkels L, Mythreye K, Lee N
J Biol Chem, 2014;289(37):25486-96.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Cystatin B is a progression marker of human epithelial ovarian tumors mediated by the TGF-beta signaling pathway.
Authors: Wang X, Gui L, Zhang Y, Zhang J, Shi J, Xu G
Int J Oncol, 2014;44(4):1099-106.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Arsenic trioxide inhibits transforming growth factor-beta1-induced fibroblast to myofibroblast differentiation in vitro and bleomycin induced lung fibrosis in vivo.
Authors: Luo F, Zhuang Y, Sides M, Sanchez C, Shan B, White E, Lasky J
Respir Res, 2014;15(0):51.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The E3 deubiquitinase USP17 is a positive regulator of retinoic acid-related orphan nuclear receptor gammat (RORgammat) in Th17 cells.
Authors: Han L, Yang J, Wang X, Wu Q, Yin S, Li Z, Zhang J, Xing Y, Chen Z, Tsun A, Li D, Piccioni M, Zhang Y, Guo Q, Jiang L, Bao L, Lv L, Li B
J Biol Chem, 2014;289(37):25546-55.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Epithelial-mesenchymal status influences how cells deposit fibrillin microfibrils.
Authors: Baldwin A, Cain S, Lennon R, Godwin A, Merry C, Kielty C
J Cell Sci, 2014;127(0):158-71.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Transforming growth factor-beta-induced miR143 expression in regulation of non-small cell lung cancer cell viability and invasion capacity in vitro and in vivo.
Authors: Cheng T, Hu C, Yang H, Cao L, An J
Int J Oncol, 2014;45(5):1977-88.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Analysis of the effects of five factors relevant to in vitro chondrogenesis of human mesenchymal stem cells using factorial design and high throughput mRNA-profiling.
Authors: Jakobsen R, Ostrup E, Zhang X, Mikkelsen T, Brinchmann J
PLoS ONE, 2014;9(5):e96615.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Amniotic fluid stem cells prevent follicle atresia and rescue fertility of mice with premature ovarian failure induced by chemotherapy.
Authors: Xiao, Guan-Yu, Liu, I-Hsuan, Cheng, Chun-Chu, Chang, Chia-Chu, Lee, Yen-Hua, Cheng, Winston, Wu, Shinn-Ch
PLoS ONE, 2014;9(9):e106538.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

TNF-like ligand 1A (TL1A) gene knockout leads to ameliorated collagen-induced arthritis in mice: implication of TL1A in humoral immune responses.
Authors: Wang X, Hu Y, Charpentier T, Lamarre A, Qi S, Wu J, Luo H
J Immunol, 2013;191(11):5420-9.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Cell adhesion and shape regulate TGF-beta1-induced epithelial-myofibroblast transition via MRTF-A signaling.
Authors: O'Connor J, Gomez E
PLoS ONE, 2013;8(12):e83188.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Kynurenine 3-monooxygenase mediates inhibition of Th17 differentiation via catabolism of endogenous aryl hydrocarbon receptor ligands.
Authors: Stephens G, Wang Q, Swerdlow B, Bhat G, Kolbeck R, Fung M
Eur J Immunol, 2013;43(7):1727-34.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Characterisation of syncytiotrophoblast vesicles in normal pregnancy and pre-eclampsia: expression of Flt-1 and endoglin.
Authors: Tannetta D, Dragovic R, Gardiner C, Redman C, Sargent I
PLoS ONE, 2013;8(2):e56754.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Blockade of Smad signaling by 3'-deoxyadenosine: a mechanism for its anti-fibrotic potential.
Authors: Gu L, Johno H, Nakajima S, Kato H, Takahashi S, Katoh R, Kitamura M
Lab Invest, 2013;93(4):450-61.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Monitoring and robust induction of nephrogenic intermediate mesoderm from human pluripotent stem cells.
Authors: Mae, Shin-Ich, Shono, Akemi, Shiota, Fumihiko, Yasuno, Tetsuhik, Kajiwara, Masatosh, Gotoda-Nishimura, Nanaka, Arai, Sayaka, Sato-Otubo, Aiko, Toyoda, Taro, Takahashi, Kazutosh, Nakayama, Naoki, Cowan, Chad A, Aoi, Takashi, Ogawa, Seishi, McMahon, Andrew P, Yamanaka, Shinya, Osafune, Kenji
Nat Commun, 2013;4(0):1367.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Identification of bone morphogenetic protein 7 (BMP7) as an instructive factor for human epidermal Langerhans cell differentiation.
Authors: Yasmin N, Bauer T, Modak M, Wagner K, Schuster C, Koffel R, Seyerl M, Stockl J, Elbe-Burger A, Graf D, Strobl H
J Exp Med, 2013;210(12):2597-610.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Regulatory B cells suppress imiquimod-induced, psoriasis-like skin inflammation.
Authors: Yanaba K, Kamata M, Ishiura N, Shibata S, Asano Y, Tada Y, Sugaya M, Kadono T, Tedder T, Sato S
J Leukoc Biol, 2013;94(4):563-73.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs.
Authors: Chen, Jiekai, Liu, He, Liu, Jing, Qi, Jing, Wei, Bei, Yang, Jiaqi, Liang, Hanquan, Chen, You, Chen, Jing, Wu, Yaran, Guo, Lin, Zhu, Jieying, Zhao, Xiangjie, Peng, Tianran, Zhang, Yixin, Chen, Shen, Li, Xuejia, Li, Dongwei, Wang, Tao, Pei, Duanqing
Nat Genet, 2013;45(1):34-42.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Butyrophilin Btn2a2 inhibits TCR activation and phosphatidylinositol 3-kinase/Akt pathway signaling and induces Foxp3 expression in T lymphocytes.
Authors: Ammann J, Cooke A, Trowsdale J
J Immunol, 2013;190(10):5030-6.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Foxm1 transcription factor is required for lung fibrosis and epithelial-to-mesenchymal transition.
Authors: Balli D, Ustiyan V, Zhang Y, Wang I, Masino A, Ren X, Whitsett J, Kalinichenko V, Kalin T
EMBO J, 2013;32(2):231-44.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Canonical transforming growth factor-beta signaling regulates disintegrin metalloprotease expression in experimental renal fibrosis via miR-29.
Authors: Ramdas V, McBride M, Denby L, Baker A
Am J Pathol, 2013;183(6):1885-96.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Low PIP4K2B expression in human breast tumors correlates with reduced patient survival: A role for PIP4K2B in the regulation of E-cadherin expression.
Authors: Keune W, Sims A, Jones D, Bultsma Y, Lynch J, Jirstrom K, Landberg G, Divecha N
Cancer Res, 2013;73(23):6913-25.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Role of IGF-1 pathway in lung fibroblast activation.
Authors: Hung C, Rohani M, Lee S, Chen P, Schnapp L
Respir Res, 2013;14(0):102.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

Apurinic/apyrimidinic endonuclease 1 is the essential nuclease during immunoglobulin class switch recombination.
Authors: Masani, Shahnaz, Han, Li, Yu, Kefei
Mol Cell Biol, 2013;33(7):1468-73.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Neuropilin-2 Is upregulated in lung cancer cells during TGF-beta1-induced epithelial-mesenchymal transition.
Authors: Nasarre P, Gemmill R, Potiron V, Roche J, Lu X, Baron A, Korch C, Garrett-Mayer E, Lagana A, Howe P, Drabkin H
Cancer Res, 2013;73(23):7111-21.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Interleukin-17A+ cell counts are increased in systemic sclerosis skin and their number is inversely correlated with the extent of skin involvement.
Authors: Truchetet M, Brembilla N, Montanari E, Lonati P, Raschi E, Zeni S, Fontao L, Meroni P, Chizzolini C
Arthritis Rheum, 2013;65(5):1347-56.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

TGF-beta1 promotes lymphangiogenesis during peritoneal fibrosis.
Authors: Kinashi H, Ito Y, Mizuno M, Suzuki Y, Terabayashi T, Nagura F, Hattori R, Matsukawa Y, Mizuno T, Noda Y, Nishimura H, Nishio R, Maruyama S, Imai E, Matsuo S, Takei Y
J Am Soc Nephrol, 2013;24(10):1627-42.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Downregulation of Dickkopf-3 disrupts prostate acinar morphogenesis through TGF-beta/Smad signalling.
Authors: Romero D, Kawano Y, Bengoa N, Walker M, Maltry N, Niehrs C, Waxman J, Kypta R
J Cell Sci, 2013;126(0):1858-67.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

MiR-1 and miR-200 inhibit EMT via Slug-dependent and tumorigenesis via Slug-independent mechanisms.
Authors: Liu Y, Yin J, Abou-Kheir W, Hynes P, Casey O, Fang L, Yi M, Stephens R, Seng V, Sheppard-Tillman H, Martin P, Kelly K
Oncogene, 2013;32(3):296-306.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

MicroRNA-22 is a master regulator of bone morphogenetic protein-7/6 homeostasis in the kidney.
Authors: Long, Jianyin, Badal, Shawn S, Wang, Yin, Chang, Benny H, Rodriguez, Antony, Danesh, Farhad R
J Biol Chem, 2013;288(51):36202-14.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Transforming growth factor β-1 stimulates profibrotic epithelial signaling to activate pericyte-myofibroblast transition in obstructive kidney fibrosis.
Am J Pathol, 2013;182(1):118-31.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Loss of canonical Smad4 signaling promotes KRAS driven malignant transformation of human pancreatic duct epithelial cells and metastasis.
Authors: Leung L, Radulovich N, Zhu C, Wang D, To C, Ibrahimov E, Tsao M
PLoS ONE, 2013;8(12):e84366.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

FOG2 protein down-regulation by transforming growth factor-beta1-induced microRNA-200b/c leads to Akt kinase activation and glomerular mesangial hypertrophy related to diabetic nephropathy.
Authors: Park J, Kato M, Yuan H, Castro N, Lanting L, Wang M, Natarajan R
J Biol Chem, 2013;288(31):22469-80.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

JNK inhibitor SP600125 enhances TGF-beta-induced apoptosis of RBE human cholangiocarcinoma cells in a Smad-dependent manner.
Authors: Lin Y, Zhang B, Liang H, Lu Y, Ai X, Zhang B, Chen X
Mol Med Rep, 2013;8(6):1623-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

In vitro generated Th17 cells support the expansion and phenotypic stability of CD4(+)Foxp3(+) regulatory T cells in vivo.
Authors: Zhou Q, Hu Y, Howard O, Oppenheim J, Chen X
Cytokine, 2013;65(1):56-64.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

The reprogramming of tumor stroma by HSF1 is a potent enabler of malignancy.
Authors: Scherz-Shouval R, Santagata S, Mendillo M, Sholl L, Ben-Aharon I, Beck A, Dias-Santagata D, Koeva M, Stemmer S, Whitesell L, Lindquist S
Cell, 2013;158(3):564-78.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Rapamycin-treated human endothelial cells preferentially activate allogeneic regulatory T cells.
Authors: Wang C, Yi T, Qin L, Maldonado R, von Andrian U, Kulkarni S, Tellides G, Pober J
J Clin Invest, 2013;123(4):1677-93.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Transforming growth factor-beta1 inhibits trophoblast cell invasion by inducing Snail-mediated down-regulation of vascular endothelial-cadherin protein.
Authors: Cheng J, Chang H, Leung P
J Biol Chem, 2013;288(46):33181-92.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

TGF-beta mediates homing of bone marrow-derived human mesenchymal stem cells to glioma stem cells.
Authors: Shinojima N, Hossain A, Takezaki T, Fueyo J, Gumin J, Gao F, Nwajei F, Marini F, Andreeff M, Kuratsu J, Lang F
Cancer Res, 2013;73(7):2333-44.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Tamoxifen ameliorates peritoneal membrane damage by blocking mesothelial to mesenchymal transition in peritoneal dialysis.
Authors: Loureiro J, Sandoval P, del Peso G, Gonzalez-Mateo G, Fernandez-Millara V, Santamaria B, Bajo M, Sanchez-Tomero J, Guerra-Azcona G, Selgas R, Lopez-Cabrera M, Aguilera A
PLoS ONE, 2013;8(4):e61165.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Role of TREM1-DAP12 in renal inflammation during obstructive nephropathy.
Authors: Tammaro A, Stroo I, Rampanelli E, Blank F, Butter L, Claessen N, Takai T, Colonna M, Leemans J, Florquin S, Dessing M
PLoS ONE, 2013;8(12):e82498.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of human tegumentary leishmaniasis.
Authors: Oliveira W, Ribeiro L, Schrieffer A, Machado P, Carvalho E, Bacellar O
Cytokine, 2013;66(2):127-32.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

MicroRNA-132 suppresses autoimmune encephalomyelitis by inducing cholinergic anti-inflammation: a new Ahr-based exploration.
Authors: Hanieh H, Alzahrani A
Eur J Immunol, 2013;43(10):2771-82.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Src-mediated morphology transition of lung cancer cells in three-dimensional organotypic culture.
Authors: Nguyen H, Zhuang Y, Sun L, Kantrow S, Kolls J, You Z, Zhuo Y, Shan B
Cancer Cell Int, 2013;13(1):16.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Hedgehog-Gli activators direct osteo-chondrogenic function of bone morphogenetic protein toward osteogenesis in the perichondrium.
Authors: Hojo, Hironori, Ohba, Shinsuke, Taniguchi, Kiyomi, Shirai, Masataka, Yano, Fumiko, Saito, Taku, Ikeda, Toshiyuk, Nakajima, Keiji, Komiyama, Yuske, Nakagata, Naomi, Suzuki, Kentaro, Mishina, Yuji, Yamada, Masahisa, Konno, Tomohiro, Takato, Tsuyoshi, Kawaguchi, Hiroshi, Kambara, Hideki, Chung, Ung-il
J Biol Chem, 2013;288(14):9924-32.
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay

Human hair follicle stem cell differentiation into contractile smooth muscle cells is induced by transforming growth factor-beta1 and platelet-derived growth factor BB.
Authors: Xu Z, Zhang Q, Li H
Mol Med Rep, 2013;8(6):1715-21.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Inactivation of the Hippo tumour suppressor pathway by integrin-linked kinase.
Authors: Serrano, Isabel, McDonald, Paul C, Lock, Frances, Muller, William, Dedhar, Shoukat
Nat Commun, 2013;4(0):2976.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Expression regulation of co-inhibitory molecules on human natural killer cells in response to cytokine stimulations.
Authors: Sun H, Sun C, Xiao W
Cytokine, 2013;65(1):33-41.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

TGF-Beta suppresses VEGFA-mediated angiogenesis in colon cancer metastasis.
Authors: Geng L, Chaudhuri A, Talmon G, Wisecarver J, Wang J
PLoS ONE, 2013;8(3):e59918.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

TGF-beta1 regulation of estrogen production in mature rat Leydig cells.
Authors: Liu M, Wang H, Wang Z, Zhang Y, Chen Y, Zhu F, Zhang Y, Ma J, Li Z
PLoS ONE, 2013;8(3):e60197.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Dendritic cell podosome dynamics does not depend on the F-actin regulator SWAP-70.
Authors: Gotz A, Jessberger R
PLoS ONE, 2013;8(3):e60642.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Bioassay

A Local Paracrine and Endocrine Network Involving TGF beta, Cox-2, ROS, and Estrogen Receptor beta Influences Reactive Stromal Cell Regulation of Prostate Cancer Cell Motility.
Authors: Grubisha MJ, Cifuentes ME, Hammes SR, Defranco DB
Mol. Endocrinol., 2012;26(6):940-54.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Human Herpesvirus 8 (HHV8) sequentially shapes the NK cell repertoire during the course of asymptomatic infection and Kaposi sarcoma.
Authors: Dupuy S, Lambert M, Zucman D, Choukem SP, Tognarelli S, Pages C, Lebbe C, Caillat-Zucman S
PLoS Pathog., 2012;8(1):e1002486.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Tumor Microenvironment Macrophage Inhibitory Factor Directs the Accumulation of Interleukin-17-producing Tumor-infiltrating Lymphocytes and Predicts Favorable Survival in Nasopharyngeal Carcinoma Patients.
Authors: Li J, Mo H, Xiong G, Zhang L, He J, Huang Z, Liu Z, Chen Q, Du Z, Zheng L, Qian C, Zeng Y
J Biol Chem, 2012;287(42):35484-95.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.
Authors: Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, Sutherlin DP, Koeppen H, Merchant M, Neve R, Settleman J
Nature, 2012;487(7408):505-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Non-Canonical Smads Phosphorylation Induced by the Glutamate Release Inhibitor, Riluzole, through GSK3 Activation in Melanoma.
Authors: Abushahba W, Olabisi O, Jeong B, Boregowda R, Wen Y, Liu F, Goydos J, Lasfar A, Cohen-Solal K
PLoS ONE, 2012;7(10):e47312.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Identification of Axl as a downstream effector of TGF-beta1 during Langerhans cell differentiation and epidermal homeostasis.
J. Exp. Med., 2012;209(11):2033-47.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

T-Lymphocytes Enable Osteoblast Maturation via IL-17F during the Early Phase of Fracture Repair.
Authors: Nam D, Mau E, Wang Y, Wright D, Silkstone D, Whetstone H, Whyne C, Alman B
PLoS ONE, 2012;7(6):e40044.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Host-derived MCP-1 and MIP-1alpha regulate protective anti-tumor immunity to localized and metastatic B16 melanoma.
Authors: Nakasone Y, Fujimoto M, Matsushita T, Hamaguchi Y, Huu DL, Yanaba M, Sato S, Takehara K, Hasegawa M
Am. J. Pathol., 2012;180(1):365-74.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Matrix metalloproteinase-13 (MMP-13) directly and indirectly promotes tumor angiogenesis.
Authors: Kudo, Yasusei, Iizuka, Shinji, Yoshida, Maki, Tsunematsu, Takaaki, Kondo, Tomoyuki, Subarnbhesaj, Ajiravud, Deraz, Elsayed, Siriwardena, Samadara, Tahara, Hidetosh, Ishimaru, Naozumi, Ogawa, Ikuko, Takata, Takashi
J Biol Chem, 2012;287(46):38716-28.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Laminin-411 Is a Vascular Ligand for MCAM and Facilitates TH17 Cell Entry into the CNS.
Authors: Flanagan K, Fitzgerald K, Baker J
PLoS ONE, 2012;7(7):e40443.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Progenitor-like traits contribute to patient survival and prognosis in oligodendroglial tumors.
Clin. Cancer Res., 2012;18(15):4122-35.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Antigen-independent differentiation and maintenance of effector-like resident memory T cells in tissues.
Authors: Casey KA, Fraser KA, Schenkel JM, Moran A, Abt MC, Beura LK, Lucas PJ, Artis D, Wherry EJ, Hogquist K, Vezys V, Masopust D
J. Immunol., 2012;188(10):4866-75.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Protein phosphatase 5 modulates SMAD3 function in the transforming growth factor-beta pathway.
Authors: Bruce D, Macartney T, Yong W, Shou W, Sapkota G
Cell Signal, 2012;24(11):1999-2006.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Hic-5 promotes invadopodia formation and invasion during TGF-beta-induced epithelial-mesenchymal transition.
Authors: Pignatelli J, Tumbarello DA, Schmidt RP, Turner CE
J. Cell Biol., 2012;197(3):421-37.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

CD69 regulates type I IFN-induced tolerogenic signals to mucosal CD4 T cells that attenuate their colitogenic potential.
Authors: Radulovic K, Manta C, Rossini V, Holzmann K, Kestler HA, Wegenka UM, Nakayama T, Niess JH
J. Immunol., 2012;188(4):2001-13.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Signalling pathways mediating specific synergistic interactions between GDF9 and BMP15.
Authors: Mottershead D, Ritter L, Gilchrist R
Mol Hum Reprod, 2012;18(3):121-8.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Lumican, an extracellular matrix proteoglycan, is a novel requisite for hepatic fibrosis.
Authors: Krishnan A, Li X, Kao W, Viker K, Butters K, Masuoka H, Knudsen B, Gores G, Charlton M
Lab Invest, 2012;92(12):1712-25.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Targeting Axl with an high-affinity inhibitory aptamer.
Authors: Cerchia, Laura, Esposito, Carla L, Camorani, Simona, Rienzo, Anna, Stasio, Loredana, Insabato, Luigi, Affuso, Andrea, de Franciscis, Vittorio
Mol Ther, 2012;20(12):2291-303.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

TGF beta1-Induced Baf60c Regulates both Smooth Muscle Cell Commitment and Quiescence.
Authors: Sohni A, Mulas F, Ferrazzi F, Luttun A, Bellazzi R, Huylebroeck D, Ekker S, Verfaillie C
PLoS ONE, 2012;7(10):e47629.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells.
Nat. Med., 2012;1248(0):18.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Role of Smad proteins in resistance to BMP-induced growth inhibition in B-cell lymphoma.
Authors: Huse K, Bakkebo M, Walchli S, Oksvold M, Hilden V, Forfang L, Bredahl M, Liestol K, Alizadeh A, Smeland E, Myklebust J
PLoS ONE, 2012;7(10):e46117.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

IL-26 Is Overexpressed in Rheumatoid Arthritis and Induces Proinflammatory Cytokine Production and Th17 Cell Generation.
Authors: Corvaisier M, Delneste Y, Jeanvoine H, Preisser L, Blanchard S, Garo E, Hoppe E, Barre B, Audran M, Bouvard B, Saint-Andre J, Jeannin P
PLoS Biol, 2012;10(9):e1001395.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF.
Authors: El-Behi M, Ciric B, Dai H
Nat. Immunol., 2011;12(6):568-75.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Lung-derived mesenchymal stromal cell post-transplantation survival, persistence, paracrine expression, and repair of elastase-injured lung.
Authors: Hoffman AM, Paxson JA, Mazan MR, Davis AM, Tyagi S, Murthy S, Ingenito EP
Stem Cells Dev., 2011;20(10):1779-92.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Nonmyelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche.
Authors: Yamazaki S, Ema H, Karlsson G, Yamaguchi T, Miyoshi H, Shioda S, Taketo MM, Karlsson S, Iwama A, Nakauchi H
Cell, 2011;147(5):1146-58.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Xanthine oxidoreductase promotes the inflammatory state of mononuclear phagocytes through effects on chemokine expression, peroxisome proliferator-activated receptor-gamma sumoylation, and HIF-1alpha.
Authors: Gibbings S, Elkins ND, Fitzgerald H, Tiao J, Weyman ME, Shibao G, Fini MA, Wright RM
J. Biol. Chem., 2011;286(2):961-75.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Identification of TROP2 (TACSTD2), an EpCAM-like molecule, as a specific marker for TGF-beta1-dependent human epidermal Langerhans cells.
Authors: Eisenwort G, Jurkin J, Yasmin N, Bauer T, Gesslbauer B, Strobl H
J. Invest. Dermatol., 2011;131(10):2049-57.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

An autocrine TGF-beta/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition.
Authors: Gregory PA, Bracken CP, Smith E, Bert AG, Wright JA, Roslan S, Morris M, Wyatt L, Farshid G, Lim YY, Lindeman GJ, Shannon MF, Drew PA, Khew-Goodall Y, Goodall GJ
Mol. Biol. Cell, 2011;22(10):1686-98.
Species: Canine
Sample Types: Whole Cells
Applications: Bioassay

Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens.
Authors: DePaolo RW, Abadie V, Tang F
Nature, 2011;471(7337):220-4.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Activin A skews macrophage polarization by promoting a proinflammatory phenotype and inhibiting the acquisition of anti-inflammatory macrophage markers.
Authors: Sierra-Filardi E, Puig-Kroger A, Blanco FJ, Nieto C, Bragado R, Palomero MI, Bernabeu C, Vega MA, Corbi AL
Blood, 2011;117(19):5092-101.

Effects of high mobility group box protein-1, interleukin-1beta, and interleukin-6 on cartilage matrix metabolism in three-dimensional equine chondrocyte cultures.
Authors: Ley C, Svala E, Nilton A, Lindahl A, Eloranta ML, Ekman S, Skioldebrand E
Connect. Tissue Res., 2011;52(4):290-300.
Species: Equine
Sample Types: Whole Cells
Applications: Bioassay

Down-regulation of Kruppel-like Factor-4 (KLF4) by MicroRNA-143/145 Is Critical for Modulation of Vascular Smooth Muscle Cell Phenotype by Transforming Growth Factor-{beta} and Bone Morphogenetic Protein 4.
Authors: Davis-Dusenbery BN, Chan MC, Reno KE, Weisman AS, Layne MD, Lagna G, Hata A
J. Biol. Chem., 2011;286(32):28097-110.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation.
Authors: Jones GW, Stumhofer JS, Foster T, Twohig JP, Hertzog P, Topley N, Williams AS, Hunter CA, Jenkins BJ, Wang EC, Jones SA
FASEB J., 2011;25(1):409-19.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

The effect of conditional EFNB1 deletion in the T cell compartment on T cell development and function.
Authors: Jin W, Qi S, Luo H
BMC Immunol., 2011;12(0):68.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

NFIL3/E4BP4 controls type 2 T helper cell cytokine expression.
Authors: Kashiwada M, Cassel SL, Colgan JD
EMBO J., 2011;30(10):2071-82.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Colorectal cancer cells activate adjacent fibroblasts resulting in FGF1/FGFR3 signaling and increased invasion.
Authors: Henriksson ML, Edin S, Dahlin AM, Oldenborg PA, Oberg Ã…, Van Guelpen B, Rutegard J, Stenling R, Palmqvist R
Am. J. Pathol., 2011;178(3):1387-94.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Basigin/CD147 promotes renal fibrosis after unilateral ureteral obstruction.
Authors: Kato N, Kosugi T, Sato W, Ishimoto T, Kojima H, Sato Y, Sakamoto K, Maruyama S, Yuzawa Y, Matsuo S, Kadomatsu K
Am. J. Pathol., 2011;178(2):572-9.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Contribution of IL-17-producing gamma delta T cells to the efficacy of anticancer chemotherapy.
Authors: Ma Y, Aymeric L, Locher C, Mattarollo SR, Delahaye NF, Pereira P, Boucontet L, Apetoh L, Ghiringhelli F, Casares N, Lasarte JJ, Matsuzaki G, Ikuta K, Ryffel B, Benlagha K, Tesniere A, Ibrahim N, Dechanet-Merville J, Chaput N, Smyth MJ, Kroemer G, Zitvogel L
J. Exp. Med., 2011;208(3):491-503.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

C-reactive protein promotes diabetic kidney disease in a mouse model of type 1 diabetes.
Authors: Liu F, Chen HY, Huang XR, Chung AC, Zhou L, Fu P, Szalai AJ, Lan HY
Diabetologia, 2011;54(10):2713-23.
Species: N/A
Sample Types: N/A
Applications: ELISA (Standard)

Transcription factor Dlx2 protects from TGFbeta-induced cell-cycle arrest and apoptosis.
Authors: Yilmaz M, Maass D, Tiwari N, Waldmeier L, Schmidt P, Lehembre F, Christofori G
EMBO J., 2011;30(21):4489-99.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Induction of latency-associated peptide (transforming growth factor-beta(1)) expression on CD4+ T cells reduces Toll-like receptor 4 ligand-induced tumour necrosis factor-alpha production in a transforming growth factor-beta-dependent manner.
Authors: Boswell S, Sharif S, Alisa A, Pereira SP, Williams R, Behboudi S
Immunology, 2011;133(3):278-87.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice.
Authors: Elkabets M, Gifford AM, Scheel C, Nilsson B, Reinhardt F, Bray MA, Carpenter AE, Jirstrom K, Magnusson K, Ebert BL, Ponten F, Weinberg RA, McAllister SS
J. Clin. Invest., 2011;121(2):784-99.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

HIV-1 replication in Langerhans and interstitial dendritic cells is inhibited by neutralizing and Fc-mediated inhibitory antibodies.
Authors: Peressin M, Holl V, Schmidt S, Decoville T, Mirisky D, Lederle A, Delaporte M, Xu K, Aubertin AM, Moog C
J. Virol., 2011;85(2):1077-85.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Glycotranscriptome study reveals an enzymatic switch modulating glycosaminoglycan synthesis during B-cell development and activation.
Authors: Duchez S, Pascal V, Cogne N, Jayat-Vignoles C, Julien R, Cogne M
Eur. J. Immunol., 2011;41(12):3632-44.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Development and characterisation of an assay for furin activity.
Authors: Bourne GL, Grainger DJ
J. Immunol. Methods, 2011;364(1):101-8.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Tyrosine 23 phosphorylation-dependent cell-surface localization of annexin A2 is required for invasion and metastases of pancreatic cancer.
Authors: Zheng L, Foley K, Huang L, Leubner A, Mo G, Olino K, Edil BH, Mizuma M, Sharma R, Le DT, Anders RA, Illei PB, Van Eyk JE, Maitra A, Laheru D, Jaffee EM
PLoS ONE, 2011;6(4):e19390.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Aryl hydrocarbon receptor deficiency in T cells suppresses the development of collagen-induced arthritis.
Authors: Nakahama T, Kimura A, Nguyen NT, Chinen I, Hanieh H, Nohara K, Fujii-Kuriyama Y, Kishimoto T
Proc. Natl. Acad. Sci. U.S.A., 2011;108(34):14222-7.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Targeting of SMAD5 links microRNA-155 to the TGF-beta pathway and lymphomagenesis.
Authors: Rai D, Kim SW, McKeller MR
Proc. Natl. Acad. Sci. U.S.A., 2010;107(7):3111-6.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Transforming growth factor beta1 inhibits cystic fibrosis transmembrane conductance regulator-dependent cAMP-stimulated alveolar epithelial fluid transport via a phosphatidylinositol 3-kinase-dependent mechanism.
Authors: Roux J, Carles M, Koh H, Goolaerts A, Ganter MT, Chesebro BB, Howard M, Houseman BT, Finkbeiner W, Shokat KM, Paquet AC, Matthay MA, Pittet JF
J. Biol. Chem., 2010;285(7):4278-90.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Antigen-specific Th9 cells exhibit uniqueness in their kinetics of cytokine production and short retention at the inflammatory site.
Authors: Tan C, Aziz MK, Lovaas JD, Vistica BP, Shi G, Wawrousek EF, Gery I
J. Immunol., 2010;185(11):6795-801.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Loss of CD4+ T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells.
Authors: Jones GW, McLoughlin RM, Hammond VJ, Parker CR, Williams JD, Malhotra R, Scheller J, Williams AS, Rose-John S, Topley N, Jones SA
J. Immunol., 2010;184(4):2130-9.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Kallikrein expression and cathelicidin processing are independently controlled in keratinocytes by calcium, vitamin D(3), and retinoic acid.
Authors: Morizane S, Yamasaki K, Kabigting FD, Gallo RL
J. Invest. Dermatol., 2010;130(5):1297-306.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Identification of retinoic acid in a high content screen for agents that overcome the anti-myogenic effect of TGF-beta-1.
Authors: Krueger C, Hoffmann FM
PLoS ONE, 2010;5(11):e15511.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Recombinant expression, purification, and functional characterisation of connective tissue growth factor and nephroblastoma-overexpressed protein.
Authors: Bohr W, Kupper M, Hoffmann K, Weiskirchen R
PLoS ONE, 2010;5(12):e16000.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation.
Authors: Chang HC, Sehra S, Goswami R, Yao W, Yu Q, Stritesky GL, Jabeen R, McKinley C, Ahyi AN, Han L, Nguyen ET, Robertson MJ, Perumal NB, Tepper RS, Nutt SL, Kaplan MH
Nat. Immunol., 2010;11(6):527-34.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model.
Authors: Yoshizaki A, Yanaba K, Iwata Y
J. Immunol., 2010;185(4):2502-15.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Regulation of the IL-21 gene by the NF-kappaB transcription factor c-Rel.
Authors: Chen G, Hardy K, Bunting K
J. Immunol., 2010;185(4):2350-9.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Regulating human Th17 cells via differential expression of IL-1 receptor.
Authors: Lee WW, Kang SW, Choi J
Blood, 2010;115(3):530-40.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Human rhinoviruses induce IL-35-producing Treg via induction of B7-H1 (CD274) and sialoadhesin (CD169) on DC.
Authors: Jindra C
Eur J Immunol, 2010;40(2):321-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Crucial role of interleukin-7 in T helper type 17 survival and expansion in autoimmune disease.
Authors: Liu X, Leung S, Wang C, Tan Z, Wang J, Guo TB, Fang L, Zhao Y, Wan B, Qin X, Lu L, Li R, Pan H, Song M, Liu A, Hong J, Lu H, Zhang JZ
Nat. Med., 2010;16(2):191-7.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Expression of the HGF receptor c-met by macrophages in experimental autoimmune encephalomyelitis.
Authors: Moransard M, Sawitzky M, Fontana A, Suter T
Glia, 2010;58(5):559-71.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Glycogene expression alterations associated with pancreatic cancer epithelial-mesenchymal transition in complementary model systems.
Authors: Maupin KA, Sinha A, Eugster E, Miller J, Ross J, Paulino V, Keshamouni VG, Tran N, Berens M, Webb C, Haab BB
PLoS ONE, 2010;5(9):e13002.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

TIM-3: a novel regulatory molecule of alloimmune activation.
Authors: Boenisch O, D'Addio F, Watanabe T, Elyaman W, Magee CN, Yeung MY, Padera RF, Rodig SJ, Murayama T, Tanaka K, Yuan X, Ueno T, Jurisch A, Mfarrej B, Akiba H, Yagita H, Najafian N
J. Immunol., 2010;185(10):5806-19.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

The sensing of environmental stimuli by follicular dendritic cells promotes immunoglobulin A generation in the gut.
Authors: Suzuki K, Maruya M, Kawamoto S
Immunity, 2010;33(1):71-83.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Nuclear function of Smad7 promotes myogenesis.
Authors: Miyake T, Alli NS, McDermott JC
Mol. Cell. Biol., 2010;30(3):722-35.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Vaccination route that induces transforming growth factor beta production fails to elicit protective immunity against Leishmania donovani infection.
Authors: Bhowmick S, Mazumdar T, Ali N
Infect. Immun., 2009;77(4):1514-23.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

TLR2-activated human langerhans cells promote Th17 polarization via IL-1beta, TGF-beta and IL-23.
Authors: Aliahmadi E, Gramlich R, Grutzkau A, Hitzler M, Kruger M, Baumgrass R, Schreiner M, Wittig B, Wanner R, Peiser M
Eur. J. Immunol., 2009;39(5):1221-30.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Cytokine milieu modulates release of thymic stromal lymphopoietin from human keratinocytes stimulated with double-stranded RNA.
Authors: Kinoshita H, Takai T, Le TA, Kamijo S, Wang XL, Ushio H, Hara M, Kawasaki J, Vu AT, Ogawa T, Gunawan H, Ikeda S, Okumura K, Ogawa H
J. Allergy Clin. Immunol., 2009;123(1):179-86.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Imatinib mesylate and AMN107 inhibit PDGF-signaling in orbital fibroblasts: a potential treatment for Graves' ophthalmopathy.
Authors: van Steensel L, Paridaens D, Schrijver B, Dingjan GM, van Daele PL, van Hagen PM, van den Bosch WA, Drexhage HA, Hooijkaas H, Dik WA
Invest. Ophthalmol. Vis. Sci., 2009;50(7):3091-8.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Interferon-gamma reverses the immunosuppressive and protumoral properties and prevents the generation of human tumor-associated macrophages.
Authors: Duluc D, Corvaisier M, Blanchard S, Catala L, Descamps P, Gamelin E, Ponsoda S, Delneste Y, Hebbar M, Jeannin P
Int. J. Cancer, 2009;125(2):367-73.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

TLR-stimulated CD34 stem cell-derived human skin-like and monocyte-derived dendritic cells fail to induce Th17 polarization of naive T cells but do stimulate Th1 and Th17 memory responses.
Authors: Duraisingham SS, Hornig J, Gotch F, Patterson S
J. Immunol., 2009;183(4):2242-51.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Homeostatic role of transforming growth factor-beta in the oral cavity and esophagus of mice and its expression by mast cells in these tissues.
Authors: Vitsky A, Waire J, Pawliuk R, Bond A, Matthews D, Lacasse E, Hawes ML, Nelson C, Richards S, Piepenhagen PA, Garman RD, Andrews L, Thurberg BL, Lonning S, Ledbetter S, Ruzek MC
Am. J. Pathol., 2009;174(6):2137-49.
Species: N/A
Sample Types: N/A
Applications: Western Blot

Plasminogen activator inhibitor-1 regulates integrin alphavbeta3 expression and autocrine transforming growth factor beta signaling.
Authors: Pedroja BS, Kang LE, Imas AO, Carmeliet P, Bernstein AM
J. Biol. Chem., 2009;284(0):20708.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Glial cell type-specific subcellular localization of 14-3-3 zeta: an implication for JCV tropism.
Authors: Lamba S, Ravichandran V, Major EO
Glia, 2009;57(9):971-7.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Interleukin-17 and interferon-gamma are produced concomitantly by human coronary artery-infiltrating T cells and act synergistically on vascular smooth muscle cells.
Authors: Eid RE, Rao DA, Zhou J, Lo SF, Ranjbaran H, Gallo A, Sokol SI, Pfau S, Pober JS, Tellides G
Circulation, 2009;119(10):1424-32.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Growth factor regulation of growth factors in articular chondrocytes.
Authors: Shi S, Mercer S, Eckert GJ, Trippel SB
J. Biol. Chem., 2009;284(11):6697-704.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling.
Authors: Boniface K, Bak-Jensen KS, Li Y, Blumenschein WM, McGeachy MJ, McClanahan TK, McKenzie BS, Kastelein RA, Cua DJ, de Waal Malefyt R
J. Exp. Med., 2009;206(3):535-48.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation.
Authors: Nolan-Stevaux O, Lau J, Truitt ML, Chu GC, Hebrok M, Fernandez-Zapico ME, Hanahan D
Genes Dev., 2009;23(1):24-36.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Role of Tim-3/galectin-9 inhibitory interaction in viral-induced immunopathology: shifting the balance toward regulators.
Authors: Sehrawat S, Suryawanshi A, Hirashima M, Rouse BT
J. Immunol., 2009;182(5):3191-201.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells.
Authors: Duhen T, Geiger R, Jarrossay D, Lanzavecchia A, Sallusto F
Nat. Immunol., 2009;10(8):857-63.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

CD69+ CD4+ CD25- T cells, a new subset of regulatory T cells, suppress T cell proliferation through membrane-bound TGF-beta 1.
Authors: Han Y, Guo Q, Zhang M, Chen Z, Cao X
J. Immunol., 2009;182(1):111-20.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Normally occurring NKG2D+CD4+ T cells are immunosuppressive and inversely correlated with disease activity in juvenile-onset lupus.
Authors: Dai Z, Turtle CJ, Booth GC, Riddell SR, Gooley TA, Stevens AM, Spies T, Groh V
J. Exp. Med., 2009;206(4):793-805.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Membrane protein GARP is a receptor for latent TGF-beta on the surface of activated human Treg.
Authors: Stockis J, Colau D, Coulie PG, Lucas S
Eur. J. Immunol., 2009;39(12):3315-22.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Chemerin expression marks early psoriatic skin lesions and correlates with plasmacytoid dendritic cell recruitment.
Authors: Albanesi C, Scarponi C, Pallotta S, Daniele R, Bosisio D, Madonna S, Fortugno P, Gonzalvo-Feo S, Franssen JD, Parmentier M, De Pita O, Girolomoni G, Sozzani S
J. Exp. Med., 2009;206(1):249-58.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Proteinase-activated receptor (PAR)-2 activation impacts bone resorptive properties of human osteoarthritic subchondral bone osteoblasts.
Authors: Amiable N, Tat SK, Lajeunesse D, Duval N, Pelletier JP, Martel-Pelletier J, Boileau C
Bone, 2009;44(6):1143-50.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Mast cell-dependent contraction of human airway smooth muscle cell-containing collagen gels: influence of cytokines, matrix metalloproteases, and serine proteases.
Authors: Margulis A, Nocka KH, Brennan AM, Deng B, Fleming M, Goldman SJ, Kasaian MT
J. Immunol., 2009;183(3):1739-50.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Activation of Toll-like receptor 3 augments myofibroblast differentiation.
Authors: Sugiura H, Ichikawa T, Koarai A, Yanagisawa S, Minakata Y, Matsunaga K, Hirano T, Akamatsu K, Ichinose M
Am. J. Respir. Cell Mol. Biol., 2009;40(6):654-62.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Role of insulin-like growth factor binding protein-3 in allergic airway remodeling.
Authors: Veraldi KL, Gibson BT, Yasuoka H, Myerburg MM, Kelly EA, Balzar S, Jarjour NN, Pilewski JM, Wenzel SE, Feghali-Bostwick CA
Am. J. Respir. Crit. Care Med., 2009;180(7):611-7.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Transcriptional regulation of SM22alpha by Wnt3a: convergence with TGFbeta(1)/Smad signaling at a novel regulatory element.
Authors: Shafer SL, Towler DA
J. Mol. Cell. Cardiol., 2009;46(5):621-35.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

alpha vbeta 6 Integrin promotes the invasion of morphoeic basal cell carcinoma through stromal modulation.
Authors: Marsh D, Dickinson S, Neill GW, Marshall JF, Hart IR, Thomas GJ
Cancer Res., 2008;68(9):3295-303.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Interleukin-4 induces the activation and collagen production of cultured human intrahepatic fibroblasts via the STAT-6 pathway.
Authors: Aoudjehane L, Pissaia A, Scatton O, Podevin P, Massault PP, Chouzenoux S, Soubrane O, Calmus Y, Conti F
Lab. Invest., 2008;88(9):973-85.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Evidence of a role for B cell-activating factor of the TNF family in the pathogenesis of chronic rhinosinusitis with nasal polyps.
Authors: Kato A, Peters A, Suh L, Carter R, Harris KE, Chandra R, Conley D, Grammer LC, Kern R, Schleimer RP
J. Allergy Clin. Immunol., 2008;121(6):1385-92, 1392.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Induction of osteoclast-associated receptor, a key osteoclast costimulation molecule, in rheumatoid arthritis.
Authors: Herman S, Muller RB, Kronke G, Zwerina J, Redlich K, Hueber AJ, Gelse H, Neumann E, Muller-Ladner U, Schett G
Arthritis Rheum., 2008;58(10):3041-50.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Expression of S100A6 in cardiac myocytes limits apoptosis induced by tumor necrosis factor-alpha.
Authors: Tsoporis JN, Izhar S, Parker TG
J. Biol. Chem., 2008;283(44):30174-83.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Transforming growth factor-beta stimulates intestinal epithelial focal adhesion kinase synthesis via smad- and p38-dependent mechanisms.
Authors: Walsh MF, Ampasala DR, Hatfield J, Vander Heide R, Suer S, Rishi AK, Basson MD
Am. J. Pathol., 2008;173(2):385-99.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells.
Authors: Carlson ME, Hsu M, Conboy IM
Nature, 2008;454(7203):528-32.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Fibrogenic fibroblasts increase intercellular adhesion strength by reinforcing individual OB-cadherin bonds.
Authors: Pittet P, Lee K, Kulik AJ, Meister JJ, Hinz B
J. Cell. Sci., 2008;121(0):877-86.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Equine umbilical cord blood contains a population of stem cells that express Oct4 and differentiate into mesodermal and endodermal cell types.
Authors: Reed SA, Johnson SE
J. Cell. Physiol., 2008;215(2):329-36.
Species: Equine
Sample Types: Whole Cells
Applications: Bioassay

Engagement of the type I interferon receptor on dendritic cells inhibits T helper 17 cell development: role of intracellular osteopontin.
Authors: Shinohara ML, Kim JH, Garcia VA, Cantor H
Immunity, 2008;29(1):68-78.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Antibody-mediated blockade of integrin alpha v beta 6 inhibits tumor progression in vivo by a transforming growth factor-beta-regulated mechanism.
Authors: Van Aarsen LA, Leone DR, Ho S, Dolinski BM, McCoon PE, LePage DJ, Kelly R, Heaney G, Rayhorn P, Reid C, Simon KJ, Horan GS, Tao N, Gardner HA, Skelly MM, Gown AM, Thomas GJ, Weinreb PH, Fawell SE, Violette SM
Cancer Res., 2008;68(2):561-70.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Myogenic growth factors can decrease extraocular muscle force generation: a potential biological approach to the treatment of strabismus.
Authors: Anderson BC, Christiansen SP, McLoon LK
Invest. Ophthalmol. Vis. Sci., 2008;49(1):221-9.
Species: Rabbit
Sample Types: In Vivo
Applications: In Vivo

The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice.
Authors: Guo B, Chang EY, Cheng G
J. Clin. Invest., 2008;118(5):1680-90.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Ocular regulatory T cells distinguish monophasic from recurrent autoimmune uveitis.
Authors: Ke Y, Jiang G, Sun D, Kaplan HJ, Shao H
Invest. Ophthalmol. Vis. Sci., 2008;49(9):3999-4007.
Species: Rat
Sample Types: Aqueous Humor
Applications: Bioassay

Glioblastoma-secreted factors induce IGFBP7 and angiogenesis by modulating Smad-2-dependent TGF-beta signaling.
Authors: Pen A, Moreno MJ, Durocher Y, Deb-Rinker P, Stanimirovic DB
Oncogene, 2008;27(54):6834-44.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A potential role of thymic stromal lymphopoietin in the recruitment of macrophages to mouse intervertebral disc cells via monocyte chemotactic protein 1 induction: implications for herniated discs.
Authors: Ohba T, Haro H, Ando T, Koyama K, Hatsushika K, Suenaga F, Ohnuma Y, Nakamura Y, Katoh R, Ogawa H, Hamada Y, Nakao A
Arthritis Rheum., 2008;58(11):3510-9.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Both Th1 and Th17 are immunopathogenic but differ in other key biological activities.
Authors: Cox CA, Shi G, Yin H, Vistica BP, Wawrousek EF, Chan CC, Gery I
J. Immunol., 2008;180(11):7414-22.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Angiopoietin-like 7 secretion is induced by glaucoma stimuli and its concentration is elevated in glaucomatous aqueous humor.
Authors: Kuchtey J, Kallberg ME, Gelatt KN, Rinkoski T, Komaromy AM, Kuchtey RW
Invest. Ophthalmol. Vis. Sci., 2008;49(8):3438-48.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Specific signals involved in the long-term maintenance of radiation-induced fibrogenic differentiation: a role for CCN2 and low concentration of TGF-beta1.
Authors: Haydont V, Riser BL, Aigueperse J, Vozenin-Brotons MC
Am. J. Physiol., Cell Physiol., 2008;294(6):C1332-41.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Tumor-specific Th17-polarized cells eradicate large established melanoma.
Authors: Muranski P, Boni A, Antony PA, Cassard L, Irvine KR, Kaiser A, Paulos CM, Palmer DC, Touloukian CE, Ptak K, Gattinoni L, Wrzesinski C, Hinrichs CS, Kerstann KW, Feigenbaum L, Chan CC, Restifo NP
Blood, 2008;112(2):362-73.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Deficient TACI expression on B lymphocytes of newborn mice leads to defective Ig secretion in response to BAFF or APRIL.
Authors: Kanswal S, Katsenelson N, Selvapandiyan A, Bram RJ, Akkoyunlu M
J. Immunol., 2008;181(2):976-90.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

In vivo investigations on anti-fibrotic potential of proteasome inhibition in lung and skin fibrosis.
Authors: Fineschi S, Bongiovanni M, Donati Y, Djaafar S, Naso F, Goffin L, Argiroffo CB, Pache JC, Dayer JM, Ferrari-Lacraz S, Chizzolini C
Am. J. Respir. Cell Mol. Biol., 2008;39(4):458-65.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Osteoactivin is a novel osteoclastic protein and plays a key role in osteoclast differentiation and activity.
Authors: Sheng MH, Wergedal JE, Mohan S, Lau KH
FEBS Lett., 2008;582(10):1451-8.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Epidermal receptor activator of NF-kappaB ligand controls Langerhans cells numbers and proliferation.
Authors: Barbaroux JB, Beleut M, Brisken C, Mueller CG, Groves RW
J. Immunol., 2008;181(2):1103-8.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology.
Authors: McGeachy MJ, Bak-Jensen KS, Chen Y, Tato CM, Blumenschein W, McClanahan T, Cua DJ
Nat. Immunol., 2007;8(12):1390-7.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

A GMCSF and IL-15 fusokine leads to paradoxical immunosuppression in vivo via asymmetrical JAK/STAT signaling through the IL-15 receptor complex.
Authors: Rafei M, Wu JH, Annabi B, Lejeune L, Francois M, Galipeau J
Blood, 2007;109(5):2234-42.
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: Bioassay

High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin.
Authors: Tanno T, Bhanu NV, Oneal PA, Goh SH, Staker P, Lee YT, Moroney JW, Reed CH, Luban NL, Wang RH, Eling TE, Childs R, Ganz T, Leitman SF, Fucharoen S, Miller JL
Nat. Med., 2007;13(9):1096-101.
Species: N/A
Sample Types: N/A
Applications: Western Blot

Vitamin A metabolites induce gut-homing FoxP3+ regulatory T cells.
Authors: Kang SG, Lim HW, Andrisani OM, Broxmeyer HE, Kim CH
J. Immunol., 2007;179(6):3724-33.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

TLR3- and Th2 cytokine-dependent production of thymic stromal lymphopoietin in human airway epithelial cells.
Authors: Kato A, Favoreto S, Avila PC, Schleimer RP
J. Immunol., 2007;179(2):1080-7.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Bone morphogenetic protein 7 is elevated in patients with chronic liver disease and exerts fibrogenic effects on human hepatic stellate cells.
Authors: Tacke F, Gabele E, Bataille F, Schwabe RF, Hellerbrand C, Klebl F, Straub RH, Luedde T, Manns MP, Trautwein C, Brenner DA, Scholmerich J, Schnabl B
Dig. Dis. Sci., 2007;52(12):3404-15.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition.
Authors: Zeisberg M, Yang C, Martino M, Duncan MB, Rieder F, Tanjore H, Kalluri R
J. Biol. Chem., 2007;282(32):23337-47.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Collagen I promotes epithelial-to-mesenchymal transition in lung cancer cells via transforming growth factor-beta signaling.
Authors: Shintani Y, Maeda M, Chaika N, Johnson KR, Wheelock MJ
Am. J. Respir. Cell Mol. Biol., 2007;38(1):95-104.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Bradykinin potentiates cytokine-induced prostaglandin biosynthesis in osteoblasts by enhanced expression of cyclooxygenase 2, resulting in increased RANKL expression.
Authors: Brechter AB, Lerner UH
Arthritis Rheum., 2007;56(3):910-23.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The transforming growth factor-beta/Smad2,3 signalling axis is impaired in experimental pulmonary hypertension.
Authors: Zakrzewicz A, Kouri FM, Nejman B, Kwapiszewska G, Hecker M, Sandu R, Dony E, Seeger W, Schermuly RT, Eickelberg O, Morty RE
Eur. Respir. J., 2007;29(6):1094-104.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Crucial role of the protein C pathway in governing microvascular inflammation in inflammatory bowel disease.
Authors: Scaldaferri F, Sans M, Vetrano S, Graziani C, De Cristofaro R, Gerlitz B, Repici A, Arena V, Malesci A, Panes J, Grinnell BW, Danese S
J. Clin. Invest., 2007;117(7):1951-60.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

IL-2 is essential for TGF-beta to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells.
Authors: Zheng SG, Wang J, Wang P, Gray JD, Horwitz DA
J. Immunol., 2007;178(4):2018-27.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Microsatellite unstable colorectal cancer cell lines with truncating TGFbetaRII mutations remain sensitive to endogenous TGFbeta.
Authors: Baker K, Raut P, Jass JR
J. Pathol., 2007;213(3):257-65.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Induction of a distinct CD8 Tnc17 subset by transforming growth factor-beta and interleukin-6.
Authors: Liu SJ, Tsai JP, Shen CR, Sher YP, Hsieh CL, Yeh YC, Chou AH, Chang SR, Hsiao KN, Yu FW, Chen HW
J. Leukoc. Biol., 2007;82(2):354-60.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Vascular endothelial growth factor can signal through platelet-derived growth factor receptors.
Authors: Ball SG, Shuttleworth CA, Kielty CM
J. Cell Biol., 2007;177(3):489-500.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Advanced glycation end products decrease mesangial cell MMP-7: a role in matrix accumulation in diabetic nephropathy?
Authors: McLennan SV, Kelly DJ, Schache M, Waltham M, Dy V, Langham RG, Yue DK, Gilbert RE
Kidney Int., 2007;72(4):481-8.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1.
Authors: Biancotto A, Grivel JC, Iglehart SJ, Vanpouille C, Lisco A, Sieg SF, Debernardo R, Garate K, Rodriguez B, Margolis LB, Lederman MM
Blood, 2007;109(10):4272-9.
Species: N/A
Sample Types: N/A
Applications: ELISA (Standard)

Essential role of Smad3 in infarct healing and in the pathogenesis of cardiac remodeling.
Authors: Bujak M, Ren G, Kweon HJ, Dobaczewski M, Reddy A, Taffet G, Wang XF, Frangogiannis NG
Circulation, 2007;116(19):2127-38.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Differentiation of human circulating fibrocytes as mediated by transforming growth factor-beta and peroxisome proliferator-activated receptor gamma.
Authors: Hong KM, Belperio JA, Keane MP, Burdick MD, Strieter RM
J. Biol. Chem., 2007;282(31):22910-20.

Cross-talk between paracrine-acting cytokine and chemokine pathways promotes malignancy in benign human prostatic epithelium.
Authors: Ao M, Franco OE, Park D, Raman D, Williams K, Hayward SW
Cancer Res., 2007;67(9):4244-53.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Bone response and mechanical strength of rabbit femoral defects filled with injectable CaP cements containing TGF-beta 1 loaded gelatin microparticles.
Authors: Link DP, van den Dolder J, van den Beucken JJ, Wolke JG, Mikos AG, Jansen JA
Biomaterials, 2007;29(6):675-82.
Species: Rabbit
Sample Types: In Vivo
Applications: In Vivo

Integrin alpha3beta1 potentiates TGFbeta-mediated induction of MMP-9 in immortalized keratinocytes.
Authors: Lamar JM, Iyer V, DiPersio CM
J. Invest. Dermatol., 2007;128(3):575-86.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Cyclic stretch controls the expression of CD40 in endothelial cells by changing their transforming growth factor-beta1 response.
Authors: Korff T, Aufgebauer K, Hecker M
Circulation, 2007;116(20):2288-97.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death.
Authors: Toscano MA, Bianco GA, Ilarregui JM, Croci DO, Correale J, Hernandez JD, Zwirner NW, Poirier F, Riley EM, Baum LG, Rabinovich GA
Nat. Immunol., 2007;8(8):825-34.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Antitumor activity of ALK1 in pancreatic carcinoma cells.
Authors: Ungefroren H, Schniewind B, Groth S, Chen WB, Muerkoster SS, Kalthoff H, Fandrich F
Int. J. Cancer, 2007;120(8):1641-51.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Impairment of the antifibrotic effect of hepatocyte growth factor in lung fibroblasts from African Americans: possible role in systemic sclerosis.
Authors: Bogatkevich GS, Ludwicka-Bradley A, Highland KB, Hant F, Nietert PJ, Singleton CB, Feghali-Bostwick CA, Silver RM
Arthritis Rheum., 2007;56(7):2432-42.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The role of the activin system in keloid pathogenesis.
Authors: Mukhopadhyay A, Chan SY, Lim IJ, Phillips DJ, Phan TT
Am. J. Physiol., Cell Physiol., 2006;292(4):C1331-8.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Activin A functions as a Th2 cytokine in the promotion of the alternative activation of macrophages.
Authors: Ogawa K, Funaba M, Chen Y, Tsujimoto M
J. Immunol., 2006;177(10):6787-94.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Transforming growth factor-alpha: a major human serum factor that promotes human keratinocyte migration.
Authors: Li Y, Fan J, Chen M, Li W, Woodley DT
J. Invest. Dermatol., 2006;126(9):2096-105.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Isolation of a novel population of multipotent adult stem cells from human hair follicles.
Authors: Yu H, Fang D, Kumar SM, Li L, Nguyen TK, Acs G, Herlyn M, Xu X
Am. J. Pathol., 2006;168(6):1879-88.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

IGF-I and IGFBP-3 augment transforming growth factor-beta actions in human renal carcinoma cells.
Authors: Rosendahl AH, Forsberg G
Kidney Int., 2006;70(9):1584-90.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The injury response of oligodendrocyte precursor cells is induced by platelets, macrophages and inflammation-associated cytokines.
Authors: Rhodes KE, Raivich G, Fawcett JW
Neuroscience, 2006;140(1):87-100.
Species: Rat
Sample Types: In Vivo
Applications: In Vivo

Multipotent adult progenitor cells from swine bone marrow.
Authors: Zeng L, Rahrmann E, Hu Q, Lund T, Sandquist L, Felten M, O'Brien TD, O'Brien TD, Zhang J, Verfaillie C
Stem Cells, 2006;24(11):2355-66.
Species: Porcine
Sample Types: Whole Cells
Applications: Bioassay

Wnt3a gradient converts radial to bilateral feather symmetry via topological arrangement of epithelia.
Authors: Yue Z, Jiang TX, Widelitz RB, Chuong CM
Proc. Natl. Acad. Sci. U.S.A., 2006;103(0):951-5.
Species: Chicken
Sample Types: In Vivo
Applications: In Vivo

IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis.
Authors: Wolk K, Witte E, Wallace E, Docke WD, Kunz S, Asadullah K, Volk HD, Sterry W, Sabat R
Eur. J. Immunol., 2006;36(5):1309-23.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Regulation of SDF-1 (CXCL12) production by osteoblasts; a possible mechanism for stem cell homing.
Authors: Jung Y, Wang J, Schneider A, Sun YX, Koh-Paige AJ, Osman NI, McCauley LK, Taichman RS
Bone, 2006;38(4):497-508.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Activin A is an endogenous inhibitor of ureteric bud outgrowth from the Wolffian duct.
Authors: Maeshima A, Vaughn DA, Choi Y, Nigam SK
Dev. Biol., 2006;295(2):473-85.
Species: Rat
Sample Types: Whole Tissue
Applications: Bioassay

Activation of transforming growth factor-beta by the integrin alphavbeta8 delays epithelial wound closure.
Authors: Neurohr C, Nishimura SL, Sheppard D
Am. J. Respir. Cell Mol. Biol., 2006;35(2):252-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Normalizing the bone marrow microenvironment with p38 inhibitor reduces multiple myeloma cell proliferation and adhesion and suppresses osteoclast formation.
Authors: Nguyen AN, Stebbins EG, Henson M, O'Young G, Choi SJ, Quon D, Damm D, Reddy M, Ma JY, Haghnazari E, Kapoun AM, Medicherla S, Protter A, Schreiner GF, Kurihara N, Anderson J, Roodman GD, Navas TA, Higgins LS
Exp. Cell Res., 2006;312(10):1909-23.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Transforming growth factor-beta1 sensitivity is altered in Abl-Myc- and Raf-Myc-induced mouse pre-B-cell tumors.
Authors: Letterio J, Rudikoff E, Voong N, Bauer SR
Stem Cells, 2006;24(12):2611-7.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Transglutaminase 2 limits murine peritoneal acute gout-like inflammation by regulating macrophage clearance of apoptotic neutrophils.
Authors: Rose DM, Sydlaske AD, Agha-Babakhani A, Johnson K, Terkeltaub R
Arthritis Rheum., 2006;54(10):3363-71.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

IL-17E upregulates the expression of proinflammatory cytokines in lung fibroblasts.
Authors: Létuvé S, Lajoie-Kadoch S, Audusseau S, Rothenberg ME, Fiset PO, Ludwig MS, Hamid Q
J. Allergy Clin. Immunol., 2006;117(3):590-6.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells.
Authors: Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, Weiner HL, Kuchroo VK
Nature, 2006;441(7090):235-8.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Coordinated functions of E-cadherin and transforming growth factor beta receptor II in vitro and in vivo.
Authors: Andl CD, Fargnoli BB, Okawa T, Bowser M, Takaoka M, Nakagawa H, Klein-Szanto A, Hua X, Herlyn M, Rustgi AK
Cancer Res., 2006;66(20):9878-85.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Expression of PDGF and their receptors in human retinal pigment epithelial cells and fibroblasts: regulation by TGF-beta.
Authors: Nagineni CN, Kutty V, Detrick B, Hooks JJ
J. Cell. Physiol., 2005;203(1):35-43.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

CYP7B expression and activity in fibroblast-like synoviocytes from patients with rheumatoid arthritis: regulation by proinflammatory cytokines.
Authors: Dulos J, van der Vleuten MA, Kavelaars A, Heijnen CJ, Boots AM
Arthritis Rheum., 2005;52(3):770-8.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Enhanced apoptotic cell clearance capacity and B cell survival factor production by IL-10-activated macrophages: implications for Burkitt's lymphoma.
Authors: Pound JD, Batth BK, Johannessen I, Wood K
J. Immunol., 2005;174(5):3015-23.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Neuronal TGF-beta1 mediates IL-9/mast cell interaction and exacerbates excitotoxicity in newborn mice.
Authors: Mesples B, Fontaine RH, Lelievre V, Launay JM, Gressens P
Neurobiol. Dis., 2005;18(1):193-205.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

The CC chemokine eotaxin/CCL11 has a selective profibrogenic effect on human lung fibroblasts.
Authors: Puxeddu I, Bader R, Piliponsky AM, Reich R, Levi-Schaffer F, Berkman N
J. Allergy Clin. Immunol., 2005;117(1):103-10.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Metastable tolerance to rhesus monkey renal transplants is correlated with allograft TGF-beta 1+CD4+ T regulatory cell infiltrates.
Authors: Torrealba JR, Katayama M, Fechner JH, Jankowska-Gan E, Kusaka S, Schultz JM, Hu H, Hamawy MM, Jonker M, Wubben J, Doxiadis G, Bontrop R, Burlingham WJ, Knechtle SJ
J. Immunol., 2004;172(9):5753-64.
Species: N/A
Sample Types: N/A
Applications: Western Blot

Natural and induced CD4+CD25+ cells educate CD4+CD25- cells to develop suppressive activity: the role of IL-2, TGF-beta, and IL-10.
Authors: Zheng SG, Wang JH, Gray JD, Soucier H, Horwitz DA
J. Immunol., 2004;172(9):5213-21.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Heparin-binding EGF-like growth factor regulates human extravillous cytotrophoblast development during conversion to the invasive phenotype.
Authors: Leach RE, Kilburn B, Wang J, Liu Z, Romero R, Armant DR
Dev. Biol., 2004;266(2):223-37.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Differential gene expression and regulation of the bone morphogenetic protein antagonists follistatin and gremlin in normal and osteoarthritic human chondrocytes and synovial fibroblasts.
Authors: Tardif G, Hum D, Pelletier JP, Boileau C, Ranger P, Martel-Pelletier J
Arthritis Rheum., 2004;50(8):2521-30.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Quantification, localization, and expression of IGF-I and TGF-beta1 during growth factor-stimulated fracture healing.
Authors: Brenner N, Huning M, Stange R
Calcif. Tissue Int., 2004;74(4):388-97.
Species: Rat
Sample Types: In Vivo
Applications: In Vivo

Local delivery of growth factors from coated titanium plates increases osteotomy healing in rats.
Authors: Wildemann B, Bamdad P, Holmer Ch, Haas NP, Raschke M, Schmidmaier G
Bone, 2004;34(5):862-8.
Species: Rat
Sample Types: In Vivo
Applications: In Vivo

IL-22 increases the innate immunity of tissues.
Authors: Wolk K, Kunz S, Witte E, Friedrich M, Asadullah K, Sabat R
Immunity, 2004;21(2):241-54.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Transforming growth factor beta1 expression and activation is increased in the alcoholic rat lung.
Authors: Bechara RI, Brown LA, Roman J, Joshi PC, Guidot DM
Am. J. Respir. Crit. Care Med., 2004;170(2):188-94.
Species: Mink
Sample Types: Cell Lysates
Applications: Bioassay

Chondrocyte response to growth factors is modulated by p38 mitogen-activated protein kinase inhibition.
Authors: Studer RK, Bergman R, Stubbs T, Decker K
Arthritis Res. Ther., 2004;6(1):R56-R64.
Species: Rabbit
Sample Types: Whole Cells
Applications: Bioassay

Rapid analysis of inflammatory cytokines in cerebrospinal fluid using chip-based immunoaffinity electrophoresis.
Authors: Phillips TM
Electrophoresis, 2004;25(10):1652-9.
Species: N/A
Sample Types: N/A
Applications: Standard

Dual roles of IL-4 in lung injury and fibrosis.
Authors: Huaux F, Liu T, McGarry B, Ullenbruch M, Phan SH
J. Immunol., 2003;170(4):2083-92.
Species: Mouse
Sample Types: Whole Cells

Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3.
Authors: Chen, WanJun, Jin, Wenwen, Hardegen, Neil, Lei, Ke-Jian, Li, Li, Marinos, Nancy, McGrady, George, Wahl, Sharon M
J Exp Med, 2003;198(12):1875-86.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Estrogen modulates cutaneous wound healing by downregulating macrophage migration inhibitory factor.
Authors: Ashcroft GS, Mills SJ, Lei K, Gibbons L, Jeong MJ, Taniguchi M, Burow M, Horan MA, Wahl SM, Nakayama T
J. Clin. Invest., 2003;111(9):1309-18.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

An essential role for Scurfin in CD4+CD25+ T regulatory cells.
Authors: Khattri, Roli, Cox, Tom, Yasayko, Sue-Ann, Ramsdell, Fred
Nat Immunol, 2003;4(4):337-42.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Transforming growth factor-beta1 regulation of growth zone chondrocytes is mediated by multiple interacting pathways.
Authors: Rosado E, 2019, Schwartz Z, Sylvia VL, Dean DD, Boyan BD
91, 2002;1590(1):1-15.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Suppression of in vivo tumorigenicity of rat hepatoma cell line KDH-8 cells by soluble TGF-beta receptor type II.
Authors: Zhao W, Kobayashi M, Ding W, Yuan L, Seth P, Cornain S, Wang J, Okada F, Hosokawa M
Cancer Immunol. Immunother., 2002;51(7):381-8.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Th2 cytokine regulation of type I collagen gel contraction mediated by human lung mesenchymal cells.
Authors: Liu X, Kohyama T, Wang H, Zhu YK, Wen FQ, Kim HJ, Romberger DJ, Rennard SI
Am. J. Physiol. Lung Cell Mol. Physiol., 2002;282(5):L1049-56.
Species: N/A
Sample Types: N/A
Applications: ELISA (Standard)

Induction of a hypertrophic growth status of coronary smooth muscle cells is associated with an overexpression of TGF-beta.
Authors: Schmidt A, 2019, Gopfert C, Vlodavsky I, Volker W, Buddecke E
101211, 2002;81(3):138-44.
Species: Bovine
Sample Types: Whole Cells
Applications: Bioassay

A profibrotic function of IL-12p40 in experimental pulmonary fibrosis.
Authors: Huaux F, Arras M, Tomasi D, Barbarin V, Delos M, Coutelier JP, Vink A, Phan SH, Renauld JC, Lison D
J. Immunol., 2002;169(5):2653-61.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Stromal-derived factor 1 inhibits the cycling of very primitive human hematopoietic cells in vitro and in NOD/SCID mice.
Authors: Cashman J, Clark-Lewis I, Eaves A, Eaves C
Blood, 2002;99(3):792-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Loss of transforming growth factor counteraction on interleukin 1 mediated effects in cartilage of old mice.
Authors: Scharstuhl A, van Beuningen HM, Vitters EL, van der Kraan PM, van den Berg WB
Ann. Rheum. Dis., 2002;61(12):1095-8.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Repeated exposure induces periportal fibrosis in Schistosoma mansoni-infected baboons: role of TGF-beta and IL-4.
Authors: Farah IO, Mola PW, Kariuki TM, Nyindo M, Blanton RE, King CL
J. Immunol., 2000;164(10):5337-43.
Species: N/A
Sample Types: N/A
Applications: ELISA (Standard)

Growth factors stimulate neointimal cells in vitro and increase the thickness of the neointima formed at the neck of porcine aneurysms treated by embolization.
Authors: Desfaits AC, 48971, Raymond J, Muizelaar JP
Cigarette smoke attenuates phagocytic ability of macrophages through down-regulating Milk fat globule-EGF factor 8 (MFG-E8) expressions, 2000;31(0):498-507.
Species: Canine
Sample Types: In Vivo
Applications: In Vivo

Isoform specificity of commercially-available anti-TGF-beta antibodies.
Authors: Mozes MM, Hodics T, Kopp JB
J. Immunol. Methods, 1999;225(1):87-93.
Species: N/A
Sample Types: N/A
Applications: Western Blot

Regulation of vascular endothelial growth factor expression in human colon cancer by insulin-like growth factor-I.
Authors: Akagi Y, Liu W, Zebrowski B, Xie K, Ellis LM
Cancer Res., 1998;58(17):4008-14.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Identification of novel non-coding RNA-based negative feedback regulating the expression of the oncogenic transcription factor GLI1.
Authors: Villegas V, Rahman M, Fernandez-Barrena M, Diao Y, Liapi E, Sonkoly E, Stahle M, Pivarcsi A, Annaratone L, Sapino A, Ramirez Clavijo S, Burglin T, Shimokawa T, Ramachandran S, Kapranov P, Fernandez-Zapico M, Zaphiropoulos P
Mol Oncol, 214;8(5):912-26.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Poricoic acid A suppresses TGF-beta1-induced renal fibrosis and proliferation via the PDGF-C, Smad3 and MAPK pathways.
Authors: Li Q, Ming Y, Jia H, Wang G
Exp Ther Med, 0;21(4):289.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

An Unbiased Screen for Human Cytomegalovirus Identifies Neuropilin-2 as a Central Viral Receptor.
Authors: Martinez-Martin N, Marcandalli J, Huang C, Arthur C, Perotti M, Foglierini M, Ho H, Dosey A, Shriver S, Payandeh J, Leitner A, Lanzavecchia A, Perez L, Ciferri C
Cell, 0;174(5):1158-1171.e19.
Species: Virus
Sample Types: Recombinant Protein
Applications: Surface Plasmon Resonance (SPR

Human macrophages induce CD4(+)Foxp3(+) regulatory T cells via binding and re-release of TGF-beta.
Authors: Schmidt A, Zhang X, Joshi R, Iqbal S, Wahlund C, Gabrielsson S, Harris R, Tegner J
Immunol Cell Biol, 0;94(8):747-62.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Comparative Analysis of Protocols to Induce Human CD4+Foxp3+ Regulatory T Cells by Combinations of IL-2, TGF-beta, Retinoic Acid, Rapamycin and Butyrate.
Authors: Schmidt A, Eriksson M, Shang M, Weyd H, Tegner J
PLoS ONE, 0;11(2):e0148474.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay