What concentration of recombinant mouse IL-4, Catalog # 404-ML, should I use for my cell culture experiment?

Name: Recombinant Mouse IL-4 Protein
Brand: R&D Systems
SKU: 404-ML-01M
Rating: 4.8 (9 reviews)

We evaluate the bioactivity of Recombinant Mouse IL-4 Protein (Catalog # 404-ML) in a cell proliferation assay using M‑NFS‑60 mouse myelogenous leukemia lymphoblast cells. The ED50 for this effect is 0.5-1.5 ng/mL. This ED50 range can provide a starting point for your experiment, but we would recommend end-users perform a dose-response to determine the best concentration for their assay system. We also recommend reviewing our list of publications under the Citations tab on the product-specific web page to find reported use of our products in similar experimental layouts.

Recombinant Mouse IL-4 Protein

404-ML 300 Citations 9 Reviews Datasheet / COA / SDS

Formulations:

Catalog #	Availability	Size / Price	Qty
404-ML-010
404-ML-050
404-ML-025
404-ML-100
404-ML-01M

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Product Details

Citations (300)

FAQs

Reviews (9)

Summary Product Datasheets Carrier Free Data Images Reconstitution Calculator Background Related Research Areas

Recombinant Mouse IL-4 Protein Summary

Purity

>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

Endotoxin Level

<0.10 EU per 1 μg of the protein by the LAL method.

Activity

Measured in a cell proliferation assay using HT‑2 mouse T cells. The ED₅₀ for this effect is 0.3‑1.5 ng/mL.

Source

E. coli-derived mouse IL-4 protein
His23-Ser140, with an N-terminal Met

Accession #

P07750

N-terminal Sequence
Analysis

His23

Predicted Molecular Mass

14 kDa

Product Datasheets

Product Datasheet

COA

SDS

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

404-ML

Formulation	Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein. *1 mg pack size (01M) is supplied as a 0.2 µm filtered solution in PBS with BSA as a carrier protein.
Reconstitution	Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping	The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage:	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

404-ML/CF

Formulation	Lyophilized from a 0.2 μm filtered solution in PBS. *1 mg pack size (01M) is supplied as a 0.2 µm filtered solution in PBS.
Reconstitution	Reconstitute at 100 μg/mL in sterile PBS.
Shipping	The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage:	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Data Images

Bioactivity

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Recombinant Mouse IL-4 (Catalog # 404-ML) stimulates cell proliferation of the HT‑2 mouse T cell line. The ED₅₀for this effect is 0.3-1.5 ng/mL.

SDS-PAGE

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1 μg/lane of Recombinant Mouse IL-4 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 12 kDa.

Reconstitution Calculator

Background: IL-4

Interleukin-4 (IL-4), also known as B cell-stimulatory factor-1, is a monomeric, approximately 13 kDa-18 kDa Th2 cytokine that shows pleiotropic effects during immune responses (1-4). It is a glycosylated polypeptide that contains three intrachain disulfide bridges and adopts a bundled four alpha -helix structure (5). Mouse IL-4 is synthesized with a 24 aa signal sequence. Mature mouse IL-4 shares 39%, 39%, and 59% aa sequence identity with bovine, human, and rat IL-4, respectively. Human, mouse, and rat IL-4 are species-specific in their activities (6-8). IL-4 exerts its effects through two receptor complexes (9, 10). The type I receptor, which is expressed on hematopoietic cells, is a heterodimer of the ligand binding IL-4 R alpha and the common gamma chain (a shared subunit of the receptors for IL-2, -7, -9, -15, and
-21). The type II receptor on nonhematopoietic cells consists of IL‑4 R alpha and IL‑13 R alpha 1. The type II receptor also transduces IL‑13 mediated signals. IL-4 is primarily expressed by Th2‑biased CD4⁺ T cells, mast cells, basophils, and eosinophils (1, 2). It promotes cell proliferation, survival, and immunoglobulin class switch to IgG1 and IgE in mouse B cells, acquisition of the Th2 phenotype by naïve CD4⁺ T cells, priming and chemotaxis of mast cells, eosinophils, and basophils, and the proliferation and activation of epithelial cells (11 ‑ 14). IL-4 plays a dominant role in the development of allergic inflammation and asthma (13, 15).

References

Benczik, M. and S.L. Gaffen (2004) Immunol. Invest. 33:109.
Chomarat, P. and J. Banchereau (1998) Int. Rev. Immunol. 17:1.
Lee, F. et al. (1986) Proc. Natl. Acad. Sci. 83:2061.
Noma, Y. et al. (1986) Nature 319:640.
Redfield, C. et al. (1991) Biochemistry 30:11029.
Ramirez, F. et al. (1988) J. Immunol. Meth. 221:141.
Leitenberg, D. and T.L. Feldbush (1988) Cell. Immunol. 111:451.
Mosman, T.R. et al. (1987) J. Immunol. 138:1813.
Mueller, T.D. et al. (2002) Biochim. Biophys. Acta 1592:237.
Nelms, K. et al. (1999) Annu. Rev. Immunol. 17:701.
Paludan, S.R. (1998) Scand. J. Immunol. 48:459.
Corthay, A. (2006) Scand. J. Immunol. 64:93.
Ryan, J.J. et al. (2007) Crit. Rev. Immunol. 27:15.
Grone, A. (2002) Vet. Immunol. Immunopathol. 88:1.
Rosenberg, H.F. et al. (2007) J. Allergy Clin. Immunol. 119:1303.

Long Name

Interleukin 4

Entrez Gene IDs

3565 (Human); 16189 (Mouse); 287287 (Rat); 397225 (Porcine); 280824 (Bovine); 403785 (Canine); 574281 (Primate); 100302454 (Rabbit)

Alternate Names

B cell growth factor 1; BCDF; B-cell stimulatory factor 1; BCGF1; BCGF-1; binetrakin; BSF1; BSF-1; IL4; IL-4; IL-4B_cell stimulatory factor 1; IL4E12; interleukin 4; interleukin-4; Lymphocyte stimulatory factor 1; MGC79402; pitrakinra

Related Research Areas

Citations for Recombinant Mouse IL-4 Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

300 Citations: Showing 1 - 10
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Adjuvant activity of Mycobacteria-derived mycolic acids
Authors: M Kubota, E Iizasa, Y Chuuma, H Kiyohara, H Hara, H Yoshida
Heliyon, 2020;6(5):e04064.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay
Environmental arginine controls multinuclear giant cell metabolism and formation
Authors: JS Brunner, L Vulliard, M Hofmann, M Kieler, A Lercher, A Vogel, M Russier, JB Brüggenthi, M Kerndl, V Saferding, B Niederreit, A Junza, A Frauenstei, C Scholtysek, Y Mikami, K Klavins, G Krönke, A Bergthaler, JJ O'Shea, T Weichhart, F Meissner, JS Smolen, P Cheng, O Yanes, J Menche, PJ Murray, O Sharif, S Blüml, G Schabbauer
Nat Commun, 2020;11(1):431.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture
Myo1e modulates the recruitment of activated B cells to inguinal lymph nodes
Authors: DA Girón-Pére, E Vadillo, M Schnoor, L Santos-Arg
J. Cell. Sci., 2020;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay
Myeloid Slc2a1-Deficient Murine Model Revealed Macrophage Activation and Metabolic Phenotype Are Fueled by GLUT1
Authors: AJ Freemerman, L Zhao, AK Pingili, B Teng, AJ Cozzo, AM Fuller, AR Johnson, JJ Milner, MF Lim, JA Galanko, MA Beck, JE Bear, JD Rotty, L Bezavada, HS Smallwood, MA Puchowicz, J Liu, JW Locasale, DP Lee, BJ Bennett, ED Abel, JC Rathmell, L Makowski
J. Immunol., 2019;0(0):.
Species: Mouse
Sample Types: Whole Cells
Nephropathy in Hypertensive Animals Is Linked to M2 Macrophages and Increased Expression of the YM1/Chi3l3 Protein
Authors: PAM Cavalcante, N Alenina, A Budu, LC Freitas-Li, T Alves-Silv, JSH Agudelo, F Qadri, NOS Camara, M Bader, RC Araújo
Mediators Inflamm., 2019;2019(0):9086758.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture
Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation
Authors: K Yasuda, Y Kitagawa, R Kawakami, Y Isaka, H Watanabe, G Kondoh, T Kohwi-Shig, S Sakaguchi, K Hirota
Nat Commun, 2019;10(1):549.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay
Distinct Requirements of CHD4 during B Cell Development and Antibody Response
Authors: WF Yen, R Sharma, M Cols, CM Lau, A Chaudhry, P Chowdhury, WT Yewdell, B Vaidyanath, A Sun, M Coffre, JN Pucella, CC Chen, M Jasin, JC Sun, AY Rudensky, SB Koralov, J Chaudhuri
Cell Rep, 2019;27(5):1472-1486.e5.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay
High activation of STAT5A drives peripheral T-cell lymphoma and leukemia
Authors: B Maurer, H Nivarthi, B Wingelhofe, HTT Pham, M Schlederer, T Suske, R Grausenbur, AI Schiefer, M Prchal-Mur, D Chen, S Winkler, O Merkel, C Kornauth, M Hofbauer, B Hochgatter, G Hoermann, A Hoelbl-Kov, J Prochazkov, C Lobello, AA Cumaraswam, J Latzka, M Kitzwögere, A Chott, A Janikova, Š Pospíšilov, JI Loizou, S Kubicek, P Valent, T Kolbe, F Grebien, L Kenner, PT Gunning, R Kralovics, M Herling, M Müller, T Rülicke, V Sexl, R Moriggl
Haematologica, 2019;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay
The Effects of Immunosuppressive Factors on Primary Dendritic Cells from C57BL/6 and CBA Mice
Authors: VV Kurilin, JN Khantakova, VP Tereschenk, JA Lopatnikov, IA Obleukhova, SV Sennikov
J Immunol Res, 2019;2019(0):7029726.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay
CD45Rb-low effector T cells require IL-4 to induce IL-10 in FoxP3 Tregs and to protect mice from inflammation
Authors: MB Jones, CA Alvarez, JL Johnson, JY Zhou, N Morris, BA Cobb
PLoS ONE, 2019;14(5):e0216893.
Species: Mouse
Sample Types: cell culture
Applications: cell cutlure

The Notch ligand DNER regulates macrophage IFN? release in chronic obstructive pulmonary disease
Authors: C Ballester-, TM Conlon, Z Ertüz, FR Greiffo, M Irmler, SE Verleden, J Beckers, IE Fernandez, O Eickelberg, AÖ Yildirim
EBioMedicine, 2019;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Resolution of Cutaneous Leishmaniasis and Persistence of Leishmania major in the Absence of Arginase 1
Authors: K Paduch, A Debus, B Rai, U Schleicher, C Bogdan
J. Immunol., 2019;0(0):.
Species: Mouse
Sample Types: Whole Cells

Cutting Edge: ATM Influences Germinal Center Integrity
Authors: L Nicolas, M Cols, R Smolkin, KC Fernandez, WT Yewdell, WF Yen, S Zha, BQ Vuong, J Chaudhuri
J. Immunol., 2019;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Ablation of RhoA impairs Th17 cell differentiation and alleviates house dust mite-triggered allergic airway inflammation
Authors: JQ Yang, KW Kalim, Y Li, Y Zheng, F Guo
J. Leukoc. Biol., 2019;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Vitamin D improves sunburns by increasing autophagy in M2 macrophages
Authors: LM Das, AM Binko, ZP Traylor, H Peng, KQ Lu
Autophagy, 2019;0(0):1-14.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Programming of macrophages by UV-irradiated apoptotic cancer cells inhibits cancer progression and lung metastasis
Authors: YB Kim, YH Ahn, JH Jung, YJ Lee, JH Lee, JL Kang
Cell. Mol. Immunol., 2019;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Lactobacillus mucosae DPC 6426 as a bile-modifying and immunomodulatory microbe
Authors: PM Ryan, EH Stolte, LEE London, JM Wells, SL Long, SA Joyce, CGM Gahan, GF Fitzgerald, RP Ross, NM Caplice, C Stanton
BMC Microbiol., 2019;19(1):33.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

The B Cell Activation-Induced miR-183 Cluster Plays a Minimal Role in Canonical Primary Humoral Responses
Authors: JN Pucella, M Cols, WF Yen, S Xu, J Chaudhuri
J. Immunol., 2019;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Trabectedin Reduces Skeletal Prostate Cancer Tumor Size in Association with Effects on M2 Macrophages and Efferocytosis
Authors: JD Jones, BP Sinder, D Paige, FN Soki, AJ Koh, S Thiele, Y Shiozawa, LC Hofbauer, S Daignault, H Roca, LK McCauley
Neoplasia, 2019;21(2):172-184.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Iron alters macrophage polarization status and leads to steatohepatitis and fibrogenesis
Authors: P Handa, S Thomas, V Morgan-Ste, BD Maliken, E Gochanour, S Boukhar, MM Yeh, KV Kowdley
J. Leukoc. Biol., 2019;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Group 2 innate lymphoid cells (ILC2) are regulated by stem cell factor during chronic asthmatic disease
Authors: W Fonseca, AJ Rasky, C Ptaschinsk, SH Morris, SKK Best, M Phillips, CA Malinczak, NW Lukacs
Mucosal Immunol, 2019;12(2):445-456.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Dendritic cells and M2 macrophage play an important role in suppression of Th2-mediated inflammation by adipose stem cells-derived extracellular vesicles
Authors: KS Cho, SA Kang, SD Kim, SJ Mun, HS Yu, HJ Roh
Stem Cell Res, 2019;39(0):101500.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Anti-cervical carcinoma effect of Portulaca oleracea L. polysaccharides by oral administration on intestinal dendritic cells
Authors: R Zhao, X Shao, G Jia, Y Huang, Z Liu, B Song, J Hou
BMC Complement Altern Med, 2019;19(1):161.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Cathepsin L secretion by host and neoplastic cells potentiates invasion
Authors: SS Dykes, HO Fasanya, DW Siemann
Oncotarget, 2019;10(53):5560-5568.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Smad7 Controls Immunoregulatory PDL2/1-PD1 Signaling in Intestinal Inflammation and Autoimmunity
Authors: LP Garo, AK Ajay, M Fujiwara, V Beynon, C Kuhn, G Gabriely, S Sadhukan, R Raheja, S Rubino, HL Weiner, G Murugaiyan
Cell Rep, 2019;28(13):3353-3366.e5.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

LncRNA PTPRE-AS1 modulates M2 macrophage activation and inflammatory diseases by epigenetic promotion of PTPRE
Authors: X Han, S Huang, P Xue, J Fu, L Liu, C Zhang, L Yang, L Xia, L Sun, SK Huang, Y Zhou
Sci Adv, 2019;5(12):eaax9230.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

Acidity promotes tumour progression by altering macrophage phenotype in prostate cancer
Authors: A El-Kenawi, C Gatenbee, M Robertson-, R Bravo, J Dhillon, Y Balaguruna, A Berglund, N Visvakarma, A Ibrahim-Ha, J Choi, K Luddy, R Gatenby, S Pilon-Thom, A Anderson, B Ruffell, R Gillies
Br. J. Cancer, 2019;121(7):556-566.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Modulation of the humoral immune response by constitutively active STAT6 expression in murine B cells
Authors: P Haase, L Mokada-Gop, D Radtke, D Voehringer
Eur. J. Immunol., 2019;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Stimulation

CD226 deficiency on regulatory T cells aggravates renal fibrosis via up-regulation of Th2 cytokines through miR-340
Authors: Y Mu, J Zhang, Y Liu, J Ma, D Jiang, X Zhang, X Yi, K Cheng, S Shen, Y Yang, R Zhuang, Y Zhang
J. Leukoc. Biol., 2019;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Impact of aging on transition of acute kidney injury to chronic kidney disease
Authors: MG Kim, J Yang, YS Ko, HY Lee, SW Oh, WY Cho, SK Jo
Sci Rep, 2019;9(1):18445.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy
Authors: E Khattar, KZY Maung, CL Chew, A Ghosh, MMH Mok, P Lee, J Zhang, WHJ Chor, G Cildir, CQ Wang, NK Mohd-Ismai, DWL Chin, SC Lee, H Yang, YJ Shin, DH Nam, L Chen, AP Kumar, LW Deng, M Ikawa, J Gunaratne, M Osato, V Tergaonkar
Nat Commun, 2019;10(1):5349.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Heterogeneity in old fibroblasts is linked to variability in reprogramming and wound healing
Authors: S Mahmoudi, E Mancini, L Xu, A Moore, F Jahanbani, K Hebestreit, R Srinivasan, X Li, K Devarajan, L Prélot, CE Ang, Y Shibuya, BA Benayoun, ALS Chang, M Wernig, J Wysocka, MT Longaker, MP Snyder, A Brunet
Nature, 2019;574(7779):553-558.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

Injectable human recombinant collagen matrices limit adverse remodeling and improve cardiac function after myocardial infarction
Authors: S McLaughlin, B McNeill, J Podrebarac, K Hosoyama, V Sedlakova, G Cron, D Smyth, R Seymour, K Goel, W Liang, KJ Rayner, M Ruel, EJ Suuronen, EI Alarcon
Nat Commun, 2019;10(1):4866.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

Stimulator of interferon genes (STING) activation exacerbates experimental colitis in mice
Authors: GR Martin, CM Blomquist, KL Henare, FR Jirik
Sci Rep, 2019;9(1):14281.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

Deletion of myeloid IRS2 enhances adipose tissue sympathetic nerve function and limits obesity
Authors: MT Rached, SJ Millership, SMA Pedroni, AI Choudhury, ASH Costa, DG Hardy, JA Glegola, EE Irvine, C Selman, MC Woodberry, VK Yadav, S Khadayate, A Vidal-Puig, S Virtue, C Frezza, DJ Withers
Mol Metab, 2019;20(0):38-50.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

B cells inhibit bone formation in rheumatoid arthritis by suppressing osteoblast differentiation
Authors: W Sun, N Meednu, A Rosenberg, J Rangel-Mor, V Wang, J Glanzman, T Owen, X Zhou, H Zhang, BF Boyce, JH Anolik, L Xing
Nat Commun, 2018;9(1):5127.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Notch ligand Delta-like 4 induces epigenetic regulation of Treg cell differentiation and function in viral infection
Authors: HA Ting, D de Almeida, AJ Rasky, CA Malinczak, IP Maillard, MA Schaller, NW Lukacs
Mucosal Immunol, 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

B cell activation and plasma cell differentiation are inhibited by de novo DNA methylation
Authors: BG Barwick, CD Scharer, RJ Martinez, MJ Price, AN Wein, RR Haines, APR Bally, JE Kohlmeier, JM Boss
Nat Commun, 2018;9(1):1900.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Androgen and Androgen Receptor as Enhancers of M2 Macrophage Polarization in Allergic Lung Inflammation
Authors: M Becerra-Dí, AB Strickland, A Keselman, NM Heller
J. Immunol., 2018;0(0):.

Crucial role of OX40/OX40L signaling in a murine model of asthma
Authors: W Lei, D Zeng, G Liu, Y Zhu, J Wang, H Wu, J Jiang, J Huang
Mol Med Rep, 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Mechanisms underlying immune tolerance caused by recombinant Echinococcus granulosus antigens Eg mMDH and Eg10 in dendritic cells
Authors: Y Wang, S Lv, Q Wang, C Wang, M Zhu, Z Ma, W Zhao
PLoS ONE, 2018;13(9):e0204868.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Characterization and allergic role of IL-33-induced neutrophil polarization
Authors: B Sun, L Zhu, Y Tao, HX Sun, Y Li, P Wang, Y Hou, Y Zhao, X Zhang, L Zhang, N Na, Y Zhao
Cell. Mol. Immunol., 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage
Authors: S Nowsheen, K Aziz, A Aziz, M Deng, B Qin, K Luo, KB Jeganathan, H Zhang, T Liu, J Yu, Y Deng, J Yuan, W Ding, JM van Deurse, Z Lou
Nat. Cell Biol., 2018;20(4):455-464.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

?M?2Is Antiatherogenic in Female but Not Male Mice
Authors: D Szpak, L Izem, D Verbovetsk, DA Soloviev, VP Yakubenko, E Pluskota
J. Immunol., 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Mining the Plasma Cell Transcriptome for Novel Cell Surface Proteins
Authors: S Trezise, A Karnowski, PL Fedele, S Mithraprab, Y Liao, K D'Costa, AJ Kueh, MP Hardy, CM Owczarek, MJ Herold, A Spencer, W Shi, SN Willis, SL Nutt, LM Corcoran
Int J Mol Sci, 2018;19(8):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

The shieldin complex mediates 53BP1-dependent DNA repair
Authors: SM Noordermee, S Adam, D Setiaputra, M Barazas, SJ Pettitt, AK Ling, M Olivieri, A Álvarez-Qu, N Moatti, M Zimmermann, S Annunziato, DB Krastev, F Song, I Brandsma, J Frankum, R Brough, A Sherker, S Landry, RK Szilard, MM Munro, A McEwan, T Goullet de, ZY Lin, T Hart, J Moffat, AC Gingras, A Martin, H van Attiku, J Jonkers, CJ Lord, S Rottenberg, D Durocher
Nature, 2018;560(7716):117-121.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Astaxanthin exerts anti-inflammatory and antioxidant effects in macrophages in NRF2-dependent and independent manners
Authors: C Farruggia, MB Kim, M Bae, Y Lee, TX Pham, Y Yang, MJ Han, YK Park, JY Lee
J. Nutr. Biochem., 2018;62(0):202-209.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Glycolipid iGb3 feedback amplifies innate immune responses via CD1d reverse signaling
Authors: X Liu, P Zhang, Y Zhang, Z Wang, S Xu, Y Li, W Huai, Q Zhou, X Chen, X Chen, N Li, P Wang, Y Li, X Cao
Cell Res., 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

LACC1 Regulates TNF and IL-17 in Mouse Models of Arthritis and Inflammation
Authors: C Skon-Hegg, J Zhang, X Wu, M Sagolla, N Ota, A Wuster, J Tom, E Doran, N Ramamoorth, P Caplazi, J Monroe, WP Lee, TW Behrens
J. Immunol., 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

The mTORC1/4E-BP/eIF4E Axis Promotes Antibody Class Switching in B Lymphocytes
Authors: H Chiu, LV Jackson, KI Oh, A Mai, ZA Ronai, D Ruggero, DA Fruman
J. Immunol., 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Interleukin 4 modulates microglia homeostasis and attenuates the early slowly progressive phase of amyotrophic lateral sclerosis
Authors: C Rossi, M Cusimano, M Zambito, A Finardi, A Capotondo, JM Garcia-Man, G Comi, R Furlan, G Martino, L Muzio
Cell Death Dis, 2018;9(2):250.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Duox1 Regulates Primary B Cell Function under the Influence of IL-4 through BCR-Mediated Generation of Hydrogen Peroxide
Authors: R Sugamata, A Donko, Y Murakami, HE Boudreau, CF Qi, J Kwon, TL Leto
J. Immunol., 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Kinase-dead ATR differs from ATR loss by limiting the dynamic exchange of ATR and RPA
Authors: D Menolfi, W Jiang, BJ Lee, T Moiseeva, Z Shao, V Estes, MG Frattini, CJ Bakkenist, S Zha
Nat Commun, 2018;9(1):5351.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Drp1 Controls Effective T Cell Immune-Surveillance by Regulating T Cell Migration, Proliferation, and cMyc-Dependent Metabolic Reprogramming
Authors: L Simula, I Pacella, A Colamatteo, C Procaccini, V Cancila, M Bordi, C Tregnago, M Corrado, M Pigazzi, V Barnaba, C Tripodo, G Matarese, S Piconese, S Campello
Cell Rep, 2018;25(11):3059-3073.e10.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

HEPES activates a MiT/TFE-dependent lysosomal-autophagic gene network in cultured cells: A call for caution
Authors: MJ Tol, MJC van der Li, TL Gabriel, JJ Hagen, S Scheij, T Veenendaal, J Klumperman, WE Donker-Koo, AJ Verhoeven, H Overkleeft, JM Aerts, CA Argmann, M van Eijk
Autophagy, 2018;0(0):1-13.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

AMPK Activation Regulates LTBP4-Dependent TGF-?1 Secretion by Pro-inflammatory Macrophages and Controls Fibrosis in Duchenne Muscular Dystrophy
Authors: G Juban, M Saclier, H Yacoub-You, A Kernou, L Arnold, C Boisson, S Ben Larbi, M Magnan, S Cuvellier, M Théret, BJ Petrof, I Desguerre, J Gondin, R Mounier, B Chazaud
Cell Rep, 2018;25(8):2163-2176.e6.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction-induced injury
Authors: AN Billin, SE Honeycutt, AV McDougal, JP Kerr, Z Chen, JM Freudenber, DK Rajpal, G Luo, HF Kramer, RS Geske, F Fang, B Yao, RV Clark, J Lepore, A Cobitz, R Miller, K Nosaka, AC Hinken, AJ Russell
Skelet Muscle, 2018;8(1):35.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

ZNF506-dependent positive feedback loop regulates H2AX signaling after DNA damage
Authors: S Nowsheen, K Aziz, K Luo, M Deng, B Qin, J Yuan, KB Jeganathan, J Yu, H Zhang, W Ding, JM van Deurse, Z Lou
Nat Commun, 2018;9(1):2736.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

The Esophageal Organoid System Reveals Functional Interplay Between Notch and Cytokines in Reactive Epithelialï¿½Changes
Authors: Y Kasagi, PM Chandramou, KA Whelan, K Tanaka, V Giroux, M Sharma, J Wang, AJ Benitez, M DeMarshall, JW Tobias, KE Hamilton, GW Falk, JM Spergel, AJ Klein-Szan, AK Rustgi, AB Muir, H Nakagawa
Cell Mol Gastroenterol Hepatol, 2018;5(3):333-352.
Species: Mouse
Sample Types: Organoids
Applications: Bioassay

REV-ERB? Regulates TH17 Cell Development and Autoimmunity
Authors: M Amir, S Chaudhari, R Wang, S Campbell, SA Mosure, LB Chopp, Q Lu, J Shang, OB Pelletier, Y He, C Doebelin, MD Cameron, DJ Kojetin, TM Kamenecka, LA Solt
Cell Rep, 2018;25(13):3733-3749.e8.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Chronic Alterations in Systemic Immune Function After Traumatic Brain Injury
Authors: R Ritzel, S Doran, J Barrett, R Henry, E Ma, A Faden, DJ Loane
J. Neurotrauma, 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

A new RelB-dependent CD117+CD172a+murine dendritic cell subset preferentially induces Th2 differentiation and supports airway hyperresponses in vivo
Authors: N Andreas, M Riemann, CN Castro, M Groth, I Koliesnik, C Engelmann, T Sparwasser, T Kamradt, R Haenold, F Weih
Eur. J. Immunol., 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Tumor-Induced Generation of Splenic Erythroblast-like Ter-Cells Promotes Tumor Progression
Authors: Y Han, Q Liu, J Hou, Y Gu, Y Zhang, Z Chen, J Fan, W Zhou, S Qiu, Y Zhang, T Dong, N Li, Z Jiang, H Zhu, Q Zhang, Y Ma, L Zhang, Q Wang, Y Yu, N Li, X Cao
Cell, 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Enhanced Pro-Inflammatory Response of Macrophages to Interleukin-33 in an Allergic Environment
Authors: N Chia, RK Kumar, PS Foster, C Herbert
Int. Arch. Allergy Immunol., 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Plasma cell differentiation is controlled by multiple cell division-coupled epigenetic programs
Authors: CD Scharer, BG Barwick, M Guo, APR Bally, JM Boss
Nat Commun, 2018;9(1):1698.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Guidance of super-enhancers in regulation of IL-9 induction and airway inflammation
Authors: X Xiao, Y Fan, J Li, X Zhang, X Lou, Y Dou, X Shi, P Lan, Y Xiao, L Minze, XC Li
J. Exp. Med., 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

Endogenous protection from ischemic brain injury by preconditioned monocytes
Authors: L Garcia-Bon, D Brea, C Benakis, D Lane, M Murphy, J Moore, G Racchumi, X Jiang, C Iadecola, J Anrather
J. Neurosci., 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

High-Resolution Mapping and Dynamics of the Transcriptome, Transcription Factors, and Transcription Co-Factor Networks in Classically and Alternatively Activated Macrophages
Authors: A Das, CS Yang, S Arifuzzama, S Kim, SY Kim, KH Jung, YS Lee, YG Chai
Front Immunol, 2018;9(0):22.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

SOCS3 deficiency in myeloid cells promotes retinal degeneration and angiogenesis through arginase-1 up-regulation in experimental autoimmune uveoretinitis
Authors: M Chen, J Zhao, IH Ali, S Marry, J Augustine, M Bhuckory, A Lynch, A Kissenpfen, H Xu
Am. J. Pathol., 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Collagen-derived peptides modulate CD4T-cell differentiation and suppress allergic responses in mice
Authors: A Nishikimi, YI Koyama, S Ishihara, S Kobayashi, C Tometsuka, M Kusubata, K Kuwaba, O Hayashida, S Hattori, K Katagiri
Immun Inflamm Dis, 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Fas Promotes T Helper 17 Cell Differentiation and Inhibits T Helper 1 Cell Development by Binding and Sequestering Transcription Factor STAT1
Authors: G Meyer Zu H, D Przybylski, MA Schramm, C Wang, A Schnell, Y Lee, R Sobel, A Regev, VK Kuchroo
Immunity, 2018;48(3):556-569.e7.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

A Newly Discovered Antifibrotic Pathway Regulated by Two Fatty Acid Receptors: GPR40 and GPR84
Authors: L Gagnon, M Leduc, JF Thibodeau, MZ Zhang, B Grouix, F Sarra-Bour, W Gagnon, K Hince, M Tremblay, L Geerts, CRJ Kennedy, RL Hébert, A Gutsol, CE Holterman, E Kamto, L Gervais, J Ouboudinar, J Richard, A Felton, A Laverdure, JC Simard, S Létourneau, MP Cloutier, FA Leblond, SD Abbott, C Penney, JS Duceppe, B Zacharie, J Dupuis, A Calderone, QT Nguyen, RC Harris, P Laurin
Am. J. Pathol., 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells

Mesenchymal stem cells ameliorate experimental arthritis via expression of interleukin-1 receptor antagonist
Authors: K Lee, N Park, H Jung, YA Rim, Y Nam, J Lee, SH Park, JH Ju
PLoS ONE, 2018;13(2):e0193086.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Differential Phagocytic Properties of CD45lowMicroglia and CD45highBrain Mononuclear Phagocytes-Activation and Age-Related Effects
Authors: S Rangaraju, SA Raza, NX Li, R Betarbet, EB Dammer, D Duong, JJ Lah, NT Seyfried, AI Levey
Front Immunol, 2018;9(0):405.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

The H2B deubiquitinase Usp22 promotes antibody class switch recombination by facilitating non-homologous end joining
Authors: C Li, T Irrazabal, CC So, M Berru, L Du, E Lam, AK Ling, JL Gommerman, Q Pan-Hammar, A Martin
Nat Commun, 2018;9(1):1006.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Myeloid p38? signaling promotes intestinal IGF-1 production and inflammation-associated tumorigenesis
Authors: C Youssif, M Cubillos-R, M Comalada, E Llonch, C Perna, N Djouder, AR Nebreda
EMBO Mol Med, 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Activated leukocyte cell adhesion molecule (ALCAM/CD166) regulates T cell responses in a murine model of food allergy
Authors: YS Kim, MN Kim, KE Lee, JY Hong, MS Oh, SY Kim, KW Kim, MH Sohn
Clin. Exp. Immunol., 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

The Crebbp Acetyltransferase is a Haploinsufficient Tumor Suppressor in B Cell Lymphoma
Authors: J Zhang, S Vlasevska, VA Wells, S Nataraj, AB Holmes, R Duval, SN Meyer, T Mo, K Basso, PK Brindle, S Hussein, R Dalla-Fave, L Pasqualucc
Cancer Discov, 2017;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

IL-4-secreting eosinophils promote endometrial stromal cell proliferation and prevent Chlamydia-induced upper genital tract damage
Authors: RD Vicetti Mi, NE Quispe Cal, D Dixon, RA Foster, A Gambotto, SD Pavelko, L Hall-Stood, TL Cherpes
Proc. Natl. Acad. Sci. U.S.A., 2017;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

The RNA Exosome Syncs IAV-RNAPII Transcription to Promote Viral Ribogenesis and Infectivity
Authors: A Rialdi, J Hultquist, D Jimenez-Mo, Z Peralta, L Campisi, R Fenouil, N Moshkina, ZZ Wang, B Laffleur, RM Kaake, MJ McGregor, K Haas, E Pefanis, RA Albrecht, L Pache, S Chanda, J Jen, J Ochando, M Byun, U Basu, A García-Sas, N Krogan, H van Bakel, I Marazzi
Cell, 2017;169(4):679-692.e14.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Nuclear Proximity of Mtr4 to RNA Exosome Restricts DNA Mutational Asymmetry
Authors: J Lim, PK Giri, D Kazadi, B Laffleur, W Zhang, V Grinstein, E Pefanis, LM Brown, E Ladewig, O Martin, Y Chen, R Rabadan, F Boyer, G Rothschild, M Cogné, E Pinaud, H Deng, U Basu
Cell, 2017;169(3):523-537.e15.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Mouse model of Epstein-Barr virus LMP1- and LMP2A-driven germinal center B-cell lymphoproliferative disease
Authors: T Minamitani, Y Ma, H Zhou, H Kida, CY Tsai, M Obana, D Okuzaki, Y Fujio, A Kumanogoh, B Zhao, H Kikutani, E Kieff, BE Gewurz, T Yasui
Proc. Natl. Acad. Sci. U.S.A, 2017;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

IL-4 upregulates cyclooxygenase-1 expression in macrophages
Authors: AE Shay, BT Diwakar, BJ Guan, V Narayan, JF Urban, KS Prabhu
J. Biol. Chem., 2017;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Selective degradation of PU.1 during autophagy represses the differentiation and antitumour activity of TH9 cells
Authors: T Rivera Var, Z Cai, Y Shen, M Dosset, I Benoit-Liz, T Martin, A Roussey, RA Flavell, F Ghiringhel, L Apetoh
Nat Commun, 2017;8(1):559.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

CD11b regulates antibody class switching via induction of AID
Authors: S Park, H Sim, HI Kim, D Jeong, G Wu, SY Cho, YS Lee, HJ Kwon, K Lee
Mol. Immunol., 2017;87(0):47-59.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

PEDF mediates pathological neovascularization by regulating macrophage recruitment and polarization in the mouse model of oxygen-induced retinopathy
Authors: S Gao, C Li, Y Zhu, Y Wang, A Sui, Y Zhong, B Xie, X Shen
Sci Rep, 2017;7(0):42846.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

TIRR regulates 53BP1 by masking its histone methyl-lysine binding function
Authors: P Drané, ME Brault, G Cui, K Meghani, S Chaubey, A Detappe, N Parnandi, Y He, XF Zheng, MV Botuyan, A Kalousi, WT Yewdell, C Münch, JW Harper, J Chaudhuri, E Soutoglou, G Mer, D Chowdhury
Nature, 2017;543(7644):211-216.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Balanced Bcl-3 expression in murine CD4(+) T cells is required for generation of encephalitogenic Th17 cells
Authors: IA Mufazalov, J Kuschmann, D Andruszews, J Masri, LA Gabriel, P Adams, S Reissig, N Hövelmeyer, A Waisman
Eur. J. Immunol., 2017;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Proof-of-Concept Gene Editing for the Murine Model of Inducible Arginase-1 Deficiency
Authors: YY Sin, PR Price, LL Ballantyne, CD Funk
Sci Rep, 2017;7(1):2585.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population
Authors: DC Nascimento, PH Melo, AR Piñeros, RG Ferreira, DF Colón, PB Donate, FV Castanheir, A Gozzi, PG Czaikoski, W Niedbala, MC Borges, DS Zamboni, FY Liew, FQ Cunha, JC Alves-Filh
Nat Commun, 2017;8(0):14919.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Cancer-derived Circulating MicroRNAs Promote Tumor Angiogenesis by Entering Dendritic Cells to Degrade Highly Complementary MicroRNAs
Authors: J Wang, H Ye, D Zhang, K Cheng, Y Hu, X Yu, L Lu, J Hu, C Zuo, B Qian, Y Yu, S Liu, G Liu, C Mao, S Liu
Theranostics, 2017;7(6):1407-1421.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

IRF-8 regulates expansion of myeloid-derived suppressor cells and Foxp3+ regulatory T cells and modulates Th2 immune responses to gastrointestinal nematode infection
Authors: RM Valanparam, M Tam, PP Gros, JP Auger, M Segura, P Gros, A Jardim, TG Geary, K Ozato, MM Stevenson
PLoS Pathog., 2017;13(10):e1006647.
Species: Mouse
Sample Types: Recombinant Protein
Applications: ELISA (Standard)

Endothelium-derived extracellular vesicles promote splenic monocyte mobilization in myocardial infarction
Authors: N Akbar, JE Digby, TJ Cahill, AN Tavare, AL Corbin, S Saluja, S Dawkins, L Edgar, N Rawlings, K Ziberna, E McNeill,, E Johnson, AA Aljabali, RA Dragovic, M Rohling, TG Belgard, IA Udalova, DR Greaves, KM Channon, PR Riley, DC Anthony, RP Choudhury
JCI Insight, 2017;2(17):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma
Authors: DK Chiu, AP Tse, IM Xu, J Di Cui, RK Lai, LL Li, HY Koh, FH Tsang, LL Wei, CM Wong, IO Ng, CC Wong
Nat Commun, 2017;8(1):517.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Opposing macrophage polarization programs show extensive epigenomic and transcriptional cross-talk
Authors: V Piccolo, A Curina, M Genua, S Ghisletti, M Simonatto, A Sabò, B Amati, R Ostuni, G Natoli
Nat. Immunol, 2017;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Preferred M2 Polarization by ASC-Based Hydrogel Accelerated Angiogenesis and Myogenesis in Volumetric Muscle Loss Rats
Authors: H Huang, J Liu, H Hao, D Chen, L Zhizhong, M Li, H Song, R Xiang, C Jiang, X Fu, W Han
Stem Cells Int, 2017;2017(0):2896874.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

TLR7 Signaling Regulates Th17 Cells and Autoimmunity: Novel Potential for Autoimmune Therapy
Authors: J Ye, Y Wang, X Liu, L Li, A Opejin, EC Hsueh, H Luo, T Wang, D Hawiger, G Peng
J. Immunol., 2017;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

The PSMP-CCR2 interactions trigger monocyte/macrophage-dependent colitis
Authors: X Pei, D Zheng, S She, J Ma, C Guo, X Mo, Y Zhang, Q Song, Y Zhang, D Ma, Y Wang
Sci Rep, 2017;7(1):5107.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Detection of immune responses after immunotherapy in glioblastoma using PET and MRI
Authors: JP Antonios, H Soto, RG Everson, DL Moughon, AC Wang, J Orpilla, C Radu, BM Ellingson, JT Lee, T Cloughesy, ME Phelps, J Czernin, LM Liau, RM Prins
Proc. Natl. Acad. Sci. U.S.A., 2017;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

miR-181a and miR-150 regulate dendritic cell immune inflammatory responses and cardiomyocyte apoptosis via targeting JAK1-STAT1/c-Fos pathway
Authors: J Zhu, K Yao, J Guo, H Shi, L Ma, Q Wang, H Liu, W Gao, A Sun, Y Zou, J Ge
J. Cell. Mol. Med., 2017;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

The transcriptional coactivator TAZ regulates reciprocal differentiation of TH17 cells and Treg cells
Authors: J Geng, S Yu, H Zhao, X Sun, X Li, P Wang, X Xiong, L Hong, C Xie, J Gao, Y Shi, J Peng, RL Johnson, N Xiao, L Lu, J Han, D Zhou, L Chen
Nat. Immunol., 2017;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Liraglutide dictates macrophage phenotype in apolipoprotein E null mice during early atherosclerosis
Authors: R Bruen, S Curley, S Kajani, D Crean, ME O'Reilly, MB Lucitt, CG Godson, FC McGillicud, O Belton
Cardiovasc Diabetol, 2017;16(1):143.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

mTORC2 controls Th9 polarization and allergic airway inflammation
Authors: H Chen, L Zhang, P Wang, H Su, W Wang, Z Chu, L Zhang, X Zhang, Y Zhao
Allergy, 2017;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Environmental sensing by mature B cells is controlled by the transcription factors PU.1 and SpiB
Authors: SN Willis, J Tellier, Y Liao, S Trezise, A Light, K O'Donnell, LA Garrett-Si, W Shi, DM Tarlinton, SL Nutt
Nat Commun, 2017;8(1):1426.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

The non-canonical poly(A) polymerase FAM46C acts as an onco-suppressor in multiple myeloma
Authors: S Mroczek, J Chlebowska, TM Kuli?ski, O Gewartowsk, J Gruchota, D Cysewski, V Liudkovska, E Borsuk, D Nowis, A Dziembowsk
Nat Commun, 2017;8(1):619.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Integrated STAT3 and Ikaros Zinc Finger Transcription Factor Activities Regulate Bcl-6 Expression in CD4(+) Th Cells
Authors: KA Read, MD Powell, CE Baker, BK Sreekumar, VM Ringel-Sca, H Bachus, RE Martin, ID Cooley, IC Allen, A Ballestero, KJ Oestreich
J. Immunol., 2017;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

The Small Rho GTPase TC10 Modulates B Cell Immune Responses
Authors: M Burbage, SJ Keppler, B Montaner, PK Mattila, FD Batista
J. Immunol., 2017;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Enhancement of antitumor immunity by combination of anti-CTLA-4 antibody and radioimmunotherapy through the suppression of Tregs
Authors: CH Son, J Bae, HR Lee, K Yang, YS Park
Oncol Lett, 2017;13(5):3781-3786.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Suppression of Th17 cell differentiation by misshapen/NIK-related kinase MINK1
Authors: G Fu, Q Xu, Y Qiu, X Jin, T Xu, S Dong, J Wang, Y Ke, H Hu, X Cao, D Wang, H Cantor, X Gao, L Lu
J. Exp. Med., 2017;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Lamtor1 Is Critically Required for CD4(+) T Cell Proliferation and Regulatory T Cell Suppressive Function
Authors: T Hosokawa, T Kimura, S Nada, T Okuno, D Ito, S Kang, S Nojima, K Yamashita, T Nakatani, Y Hayama, Y Kato, Y Kinehara, M Nishide, N Mikami, S Koyama, H Takamatsu, D Okuzaki, N Ohkura, S Sakaguchi, M Okada, A Kumanogoh
J. Immunol., 2017;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Robust growth of avirulent phase II Coxiella burnetii in bone marrow-derived murine macrophages
Authors: DC Cockrell, CM Long, SJ Robertson, JG Shannon, HE Miller, L Myers, CL Larson, T Starr, PA Beare, RA Heinzen
PLoS ONE, 2017;12(3):e0173528.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Soluble TNF Regulates TACE via AP-2? Transcription Factor in Mouse Dendritic Cells
Authors: L Ge, NL Vujanovic
J. Immunol., 2017;198(1):417-427.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Rad52 competes with Ku70/Ku86 for binding to S-region DSB ends to modulate antibody class-switch DNA recombination
Authors: H Zan, C Tat, Z Qiu, JR Taylor, JA Guerrero, T Shen, P Casali
Nat Commun, 2017;8(0):14244.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Bone-induced expression of integrin ?3 enables targeted nanotherapy of breast cancer metastases
Authors: MH Ross, AK Esser, GC Fox, AH Schmieder, X Yang, G Hu, D Pan, X Su, Y Xu, DV Novack, T Walsh, GA Colditz, GH Lukaszewic, E Cordell, JS Novack, JAJ Fitzpatric, DL Waning, KS Mohammad, TA Guise, GM Lanza, KN Weilbaeche
Cancer Res., 2017;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Therapeutic reversal of food allergen sensitivity by mature retinoic acid-differentiated dendritic cell induction of LAG3(+)CD49b(-)Foxp3(-) regulatory Tï¿½cells
Authors: W Dawicki, C Li, J Town, X Zhang, JR Gordon
J. Allergy Clin. Immunol., 2017;139(5):1608-1620.e3.
Species: Mouse
Sample Types: Serum
Applications: ELISA (Standard)

Utilization of host polyamines in alternatively activated macrophages promotes chronic infection by Brucella abortus
Authors: T Kerrinnes, MG Winter, BM Young, VE Diaz-Ochoa, SE Winter, RM Tsolis
Infect. Immun., 2017;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Identification of Novel STAT6-Regulated Proteins in Mouse B Cells by Comparative Transcriptome and Proteome Analysis
Authors: L Mokada-Gop, A Boeser, CH Lehmann, F Drepper, D Dudziak, B Warscheid, D Voehringer
J. Immunol, 2017;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Interleukin 4 receptor-targeted pro-apoptotic peptide blocks tumor growth and metastasis by enhancing anti-tumor immunity
Authors: SMP Vadevoo, JE Kim, GR Gunassekar, HK Jung, L Chi, DE Kim, SH Lee, SH Im, B Lee
Mol. Cancer Ther., 2017;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Pro-inflammatory M1 macrophages promote osteogenesis by mesenchymal stem cells via the COX-2-prostaglandin E2 pathway
Authors: LY Lu, F Loi, K Nathan, TH Lin, J Pajarinen, E Gibon, A Nabeshima, L Cordova, E Jämsen, Z Yao, SB Goodman
J. Orthop. Res, 2017;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Crosstalk between glucocorticoids and IL-4 modulates Ym1 expression in alternatively activated myeloid cells
Authors: N Ng Kuet Le, F Brombacher, AH Dalpke, M Weitnauer
Immunobiology, 2017;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

M2-polarized macrophages contribute to neovasculogenesis, leading to relapse of oral cancer following radiation
Authors: Makiko Okubo
Sci Rep, 2016;6(0):27548.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Identification and Function of Fibrocytes in Skeletal Muscle Injury Repair and Muscular Dystrophy
J. Immunol., 2016;197(12):4750-4761.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

VISTA deficiency accelerates the development of fatal murine lupus nephritis
Authors: Sabrina Ceeraz
Arthritis & rheumatology (Hoboken, N.J.), 2016;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Blockade of Extracellular ATP Effect by Oxidized ATP Effectively Mitigated Induced Mouse Experimental Autoimmune Uveitis (EAU)
PLoS ONE, 2016;11(5):e0155953.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

IL-12p40/IL-10 Producing preCD8?/Clec9A+ Dendritic Cells Are Induced in Neonates upon Listeria monocytogenes Infection
Authors: D Torres, A Köhler, S Delbauve, I Caminschi, MH Lahoud, K Shortman, V Flamand
PLoS Pathog, 2016;12(4):e1005561.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

A Lipid Based Antigen Delivery System Efficiently Facilitates MHC Class-I Antigen Presentation in Dendritic Cells to Stimulate CD8(+) T Cells
Authors: Mithun Maji
Sci Rep, 2016;6(0):27206.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Cutting Edge: Marginal Zone Macrophages Regulate Antigen Transport by B Cells to the Follicle in the Spleen via CD21
J Immunol, 2016;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Epithelia Use Butyrophilin-like Molecules to Shape Organ-Specific ?? T Cell Compartments
Authors: R Di Marco B, NA Roberts, RJ Dart, P Vantourout, A Jandke, O Nussbaumer, L Deban, S Cipolat, R Hart, ML Iannitto, A Laing, B Spencer-De, P East, D Gibbons, PM Irving, P Pereira, U Steinhoff, A Hayday
Cell, 2016;167(1):203-218.e17.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Conditioned Medium from the Stem Cells of Human Exfoliated Deciduous Teeth Ameliorates Experimental Autoimmune Encephalomyelitis
Authors: C Shimojima, H Takeuchi, S Jin, B Parajuli, H Hattori, A Suzumura, H Hibi, M Ueda, A Yamamoto
J Immunol, 2016;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Alpha 1 Antitrypsin Inhibits Dendritic Cell Activation and Attenuates Nephritis in a Mouse Model of Lupus
Authors: Ahmed S Elshikha
PLoS ONE, 2016;11(5):e0156583.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

M1/M2-macrophage phenotypes regulate renal calcium oxalate crystal development.
Authors: Kazumi Taguchi, Atsushi Okada, Shuzo Hamamoto, Rei Unno, Yoshinobu Moritoki, Ryosuke Ando, Kentaro Mizuno, Keiichi Tozawa, Kenjiro Kohri, Takahiro Yasui
Scientific Reports, 2016;0(0):2045-2322.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Pharmacologic modulation of ROR?t translates to efficacy in preclinical and translational models of psoriasis and inflammatory arthritis
Sci Rep, 2016;6(0):37977.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Toll/Interleukin-1 Receptor Domain Derived from TcpC (TIR-TcpC) Ameliorates Experimental Autoimmune Arthritis by Down-modulating Th17 Cell Response
Authors: Shweta Pasi
J Biol Chem, 2016;291(23):12358-69.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Roles of endoplasmic reticulum stress-mediated apoptosis in M1-polarized macrophages during mycobacterial infections
Sci Rep, 2016;6(0):37211.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

The aryl hydrocarbon receptor controls cell-fate decisions in B cells
Authors: Bharat Vaidyanath
J. Exp. Med, 2016;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Interferon regulatory factor 4 (IRF4) controls myeloid-derived suppressor cell (MDSC) differentiation and function
J Leukoc Biol, 2016;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Kin17 facilitates multiple double-strand break repair pathways that govern B cell class switching
Sci Rep, 2016;6(0):37215.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Polarization of macrophages towards M2 phenotype is favored by reduction in iPLA2?
J Biol Chem, 2016;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Usp9X Is Required for Lymphocyte Activation and Homeostasis through Its Control of ZAP70 Ubiquitination and PKC? Kinase Activity
Authors: E Naik, VM Dixit
J Immunol, 2016;196(8):3438-51.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Elastin-Derived Peptides Promote Abdominal Aortic Aneurysm Formation by Modulating M1/M2 Macrophage Polarization
J Immunol, 2016;196(11):4536-43.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription
Nat Commun, 2016;7(0):11624.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Egr2 and Egr3 in regulatory T cells cooperatively control systemic autoimmunity through Ltbp3-mediated TGF-?3 production
Proc. Natl. Acad. Sci. U.S.A., 2016;113(50):E8131-E8140.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

p(70S6K1) in the TORC1 pathway is essential for the differentiation of Th17 Cells, but not Th1, Th2, or Treg cells in mice.
Authors: Sasaki C, Chen G, Munk R, Eitan E, Martindale J, Longo D, Ghosh P
Eur J Immunol, 2016;46(1):212-22.

Intrinsic transcriptional heterogeneity in B cells controls early class switching to IgE
Authors: Yee Ling Wu
J. Exp. Med, 2016;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Role of interleukin-4, the chemokine CCL3 and its receptor CCR5 in neuropathic pain
Mol Immunol, 2016;77(0):184-192.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status
Circ Res, 2016;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Conditional IL-4/IL-13-deficient mice reveal a critical role of innate immune cells for protective immunity against gastrointestinal helminths.
Authors: Oeser K, Schwartz C, Voehringer D
Mucosal Immunol, 2015;8(3):672-82.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

An essential role for RGS protein/Galphai2 interactions in B lymphocyte-directed cell migration and trafficking.
Authors: Hwang I, Park C, Harrison K, Boularan C, Gales C, Kehrl J
J Immunol, 2015;194(5):2128-39.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Redundant function of DNA ligase 1 and 3 in alternative end-joining during immunoglobulin class switch recombination.
Authors: Masani S, Han L, Meek K, Yu K
Proc Natl Acad Sci U S A, 2015;113(5):1261-6.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Immunosuppression in early postnatal days induces persistent and allergen-specific immune tolerance to asthma in adult mice.
Authors: Chen, Yan, Zhang, Jin, Lu, Yong, Wang, Libo
PLoS ONE, 2015;10(4):e0122990.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Essential engagement of Toll-like receptor 2 in initiation of early protective Th1 response against rough variants of Mycobacterium abscessus.
Authors: Kim J, Kang M, Kim W, Han S, Kim H, Kim H, Kwon K, Kim S, Cha S, Eum S, Koh W, Cho S, Park J, Shin S
Infect Immun, 2015;83(4):1556-67.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Protease activity of Per a 10 potentiates Th2 polarization by increasing IL-23 and OX40L.
Authors: Agrawal K, Kale S, Arora N
Eur J Immunol, 2015;45(12):3375-85.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

mTORC2 Deficiency in Myeloid Dendritic Cells Enhances Their Allogeneic Th1 and Th17 Stimulatory Ability after TLR4 Ligation In Vitro and In Vivo.
Authors: Raich-Regue D, Rosborough B, Watson A, McGeachy M, Turnquist H, Thomson A
J Immunol, 2015;194(10):4767-76.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Exploitation of the Polymeric Immunoglobulin Receptor for Antibody Targeting to Renal Cyst Lumens in Polycystic Kidney Disease.
Authors: Olsan E, Matsushita T, Rezaei M, Weimbs T
J Biol Chem, 2015;290(25):15679-86.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Cytokine-induced killer cells co-cultured with dendritic cells loaded with the protein lysate produced by radiofrequency ablation induce a specific antitumor response.
Authors: Shan, Chan-Cha, Shi, Liang-Ro, Ding, Mei-Qian, Zhu, Yi-Bei, Li, Xiao-Don, Xu, Bin, Jiang, Jing-Tin, Wu, Chang-Pi
Oncol Lett, 2015;9(4):1549-1556.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Constraints contributed by chromatin looping limit recombination targeting during Ig class switch recombination.
Authors: Feldman S, Achour I, Wuerffel R, Kumar S, Gerasimova T, Sen R, Kenter A
J Immunol, 2015;194(5):2380-9.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Radiation-driven lipid accumulation and dendritic cell dysfunction in cancer.
Authors: Gao F, Liu C, Guo J, Sun W, Xian L, Bai D, Liu H, Cheng Y, Li B, Cui J, Zhang C, Cai J
Sci Rep, 2015;5(0):9613.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Novel mechanism of macrophage-mediated metastasis revealed in a zebrafish model of tumor development.
Authors: Wang J, Cao Z, Zhang X, Nakamura M, Sun M, Hartman J, Harris R, Sun Y, Cao Y
Cancer Res, 2015;75(2):306-15.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Toll-like receptor ligands sensitize B-cell receptor signalling by reducing actin-dependent spatial confinement of the receptor.
Authors: Freeman S, Jaumouille V, Choi K, Hsu B, Wong H, Abraham L, Graves M, Coombs D, Roskelley C, Das R, Grinstein S, Gold M
Nat Commun, 2015;6(0):6168.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Inhibition of Ca2+-independent phospholipase A2beta (iPLA2beta) ameliorates islet infiltration and incidence of diabetes in NOD mice.
Authors: Bone R, Gai Y, Magrioti V, Kokotou M, Ali T, Lei X, Tse H, Kokotos G, Ramanadham S
Diabetes, 2015;64(2):541-54.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Determining the role of IL-4 induced neuroinflammation in microglial activity and amyloid-beta using BV2 microglial cells and APP/PS1 transgenic mice.
Authors: Latta C, Sudduth T, Weekman E, Brothers H, Abner E, Popa G, Mendenhall M, Gonzalez-Oregon F, Braun K, Wilcock D
J Neuroinflammation, 2015;12(0):41.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Sca-1+Lin-CD117- mesenchymal stem/stromal cells induce the generation of novel IRF8-controlled regulatory dendritic cells through Notch-RBP-J signaling.
Authors: Liu X, Ren S, Ge C, Cheng K, Zenke M, Keating A, Zhao R
J Immunol, 2015;194(9):4298-308.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells.
Authors: Rutz S, Kayagaki N, Phung Q, Eidenschenk C, Noubade R, Wang X, Lesch J, Lu R, Newton K, Huang O, Cochran A, Vasser M, Fauber B, DeVoss J, Webster J, Diehl L, Modrusan Z, Kirkpatrick D, Lill J, Ouyang W, Dixit V
Nature, 2015;518(7539):417-21.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

IRAK-M promotes alternative macrophage activation and fibroproliferation in bleomycin-induced lung injury.
Authors: Ballinger M, Newstead M, Zeng X, Bhan U, Mo X, Kunkel S, Moore B, Flavell R, Christman J, Standiford T
J Immunol, 2015;194(4):1894-904.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Lymphocytes from chronically stressed mice confer antidepressant-like effects to naive mice.
Authors: Brachman R, Lehmann M, Maric D, Herkenham M
J Neurosci, 2015;35(4):1530-8.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production.
Authors: Khairnar V, Duhan V, Maney S, Honke N, Shaabani N, Pandyra A, Seifert M, Pozdeev V, Xu H, Sharma P, Baldin F, Marquardsen F, Merches K, Lang E, Kirschning C, Westendorf A, Haussinger D, Lang F, Dittmer U, Kuppers R, Recher M, Hardt C, Scheffrahn I, Beauchemin N, Gothert J, Singer B, Lang P, Lang K
Nat Commun, 2015;6(0):6217.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

B Cell-Intrinsic Expression of the HuR RNA-Binding Protein Is Required for the T Cell-Dependent Immune Response In Vivo.
Authors: DeMicco A, Naradikian M, Sindhava V, Yoon J, Gorospe M, Wertheim G, Cancro M, Bassing C
J Immunol, 2015;195(7):3449-62.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Impaired macrophage autophagy increases the immune response in obese mice by promoting proinflammatory macrophage polarization.
Authors: Liu K, Zhao E, Ilyas G, Lalazar G, Lin Y, Haseeb M, Tanaka K, Czaja M
Autophagy, 2015;11(2):271-84.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

The cholesterol transporter ABCG1 links cholesterol homeostasis and tumour immunity.
Authors: Sag D, Cekic C, Wu R, Linden J, Hedrick C
Nat Commun, 2015;6(0):6354.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Concentrated protein body product derived from rice endosperm as an oral tolerogen for allergen-specific immunotherapy--a new mucosal vaccine formulation against Japanese cedar pollen allergy.
Authors: Wakasa Y, Takagi H, Watanabe N, Kitamura N, Fujiwara Y, Ogo Y, Hayashi S, Yang L, Ohta M, Thet Tin W, Sekikawa K, Takano M, Ozawa K, Hiroi T, Takaiwa F
PLoS ONE, 2015;10(3):e0120209.
Species: Mouse
Sample Types: In Vivo

DNA-dependent protein kinase inhibition blocks asthma in mice and modulates human endothelial and CD4(+) T-cell function without causing severe combined immunodeficiency.
Authors: Ghonim M, Pyakurel K, Ju J, Rodriguez P, Lammi M, Davis C, Abughazleh M, Mansy M, Naura A, Boulares A
J Allergy Clin Immunol, 2015;135(2):425-40.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

The generation of macrophages with anti-inflammatory activity in the absence of STAT6 signaling.
Authors: Fleming B, Chandrasekaran P, Dillon L, Dalby E, Suresh R, Sarkar A, El-Sayed N, Mosser D
J Leukoc Biol, 2015;98(3):395-407.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Glycogen Synthase Kinase-3beta (GSK-3beta) Inhibition Enhances Dendritic Cell-based Cancer Vaccine Potency via Suppression of Interferon-gamma-induced Indoleamine 2,3-Dioxygenase Expression.
Authors: Noh K, Son K, Jung I, Kang T, Choi C, Park Y
J Biol Chem, 2015;290(19):12394-402.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Ligase I and ligase III mediate the DNA double-strand break ligation in alternative end-joining.
Authors: Lu G, Duan J, Shu S, Wang X, Gao L, Guo J, Zhang Y
Proc Natl Acad Sci U S A, 2015;113(5):1256-60.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

LKB1 inhibition of NF-kappaB in B cells prevents T follicular helper cell differentiation and germinal center formation.
Authors: Walsh N, Waters L, Fowler J, Lin M, Cunningham C, Brooks D, Rehg J, Morse H, Teitell M
EMBO Rep, 2015;16(6):753-68.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

The DNA-binding inhibitor Id3 regulates IL-9 production in CD4(+) T cells.
Authors: Nakatsukasa H, Zhang D, Maruyama T, Chen H, Cui K, Ishikawa M, Deng L, Zanvit P, Tu E, Jin W, Abbatiello B, Goldberg N, Chen Q, Sun L, Zhao K, Chen W
Nat Immunol, 2015;16(10):1077-84.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

IL-4 induces a suppressive IL-10-producing CD8+ T cell population via a Cdkn2a-dependent mechanism.
Authors: Zhao Y, Zhao H, Sun Y, Hao J, Qi X, Zhou X, Wu Z, Wang P, Kaech S, Weaver C, Flavell R, Zhao L, Yao Z, Yin Z
J Leukoc Biol, 2015;94(6):1103-12.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

S100A8 induces IL-10 and protects against acute lung injury.
Authors: Hiroshima Y, Hsu K, Tedla N, Chung Y, Chow S, Herbert C, Geczy C
J Immunol, 2014;192(6):2800-11.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

IkappaB kinase activity drives fetal lung macrophage maturation along a non-M1/M2 paradigm.
Authors: Stouch A, Zaynagetdinov R, Barham W, Stinnett A, Slaughter J, Yull F, Hoffman H, Blackwell T, Prince L
J Immunol, 2014;193(3):1184-93.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

TRAF5 negatively regulates TLR signaling in B lymphocytes.
Authors: Buchta C, Bishop G
J Immunol, 2014;192(1):145-50.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Failed renoprotection by alternatively activated bone marrow macrophages is due to a proliferation-dependent phenotype switch in vivo.
Authors: Cao Q, Wang Y, Zheng D, Sun Y, Wang C, Wang X, Lee V, Wang Y, Zheng G, Tan T, Wang Y, Alexander S, Harris D
Kidney Int, 2014;85(4):794-806.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity.
Authors: Ramkhelawon B, Hennessy E, Menager M, Ray T, Sheedy F, Hutchison S, Wanschel A, Oldebeken S, Geoffrion M, Spiro W, Miller G, McPherson R, Rayner K, Moore K
Nat Med, 2014;20(4):377-84.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

DMXAA causes tumor site-specific vascular disruption in murine non-small cell lung cancer, and like the endogenous non-canonical cyclic dinucleotide STING agonist, 2'3'-cGAMP, induces M2 macrophage repolarization.
Authors: Downey C, Aghaei M, Schwendener R, Jirik F
PLoS ONE, 2014;9(6):e99988.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Lysosomal stress in obese adipose tissue macrophages contributes to MITF-dependent Gpnmb induction.
Authors: Gabriel T, Tol M, Ottenhof R, van Roomen C, Aten J, Claessen N, Hooibrink B, de Weijer B, Serlie M, Argmann C, van Elsenburg L, Aerts J, van Eijk M
Diabetes, 2014;63(10):3310-23.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Preferential macrophage recruitment and polarization in LPS-induced animal model for COPD: noninvasive tracking using MRI.
Authors: Al Faraj, Achraf, Sultana Shaik, Asma, Pureza, Mary Ang, Alnafea, Mohammad, Halwani, Rabih
PLoS ONE, 2014;9(3):e90829.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Unique macrophages different from M1/M2 macrophages inhibit T cell mitogenesis while upregulating Th17 polarization.
Authors: Tatano Y, Shimizu T, Tomioka H
Sci Rep, 2014;4(0):4146.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Elongated TCR alpha chain CDR3 favors an altered CD4 cytokine profile.
Authors: Reynolds C, Chong D, Raynsford E, Quigley K, Kelly D, Llewellyn-Hughes J, Altmann D, Boyton R
BMC Biol, 2014;12(0):32.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Axl receptor blockade ameliorates pulmonary pathology resulting from primary viral infection and viral exacerbation of asthma.
Authors: Shibata T, Habiel D, Coelho A, Kunkel S, Lukacs N, Hogaboam C
J Immunol, 2014;192(8):3569-81.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Luminex (Standard)

Role of Blimp-1 in programing Th effector cells into IL-10 producers.
Authors: Neumann C, Heinrich F, Neumann K, Junghans V, Mashreghi M, Ahlers J, Janke M, Rudolph C, Mockel-Tenbrinck N, Kuhl A, Heimesaat M, Esser C, Im S, Radbruch A, Rutz S, Scheffold A
J Exp Med, 2014;211(9):1807-19.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Noncoding RNA transcription targets AID to divergently transcribed loci in B cells.
Authors: Pefanis, Evangelo, Wang, Jiguang, Rothschild, Gerson, Lim, Junghyun, Chao, Jaime, Rabadan, Raul, Economides, Aris N, Basu, Uttiya
Nature, 2014;514(7522):389-93.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Improved repair of dermal wounds in mice lacking microRNA-155.
Authors: van Solingen C, Araldi E, Chamorro-Jorganes A, Fernandez-Hernando C, Suarez Y
J Cell Mol Med, 2014;18(6):1104-12.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid.
Authors: Colegio O, Chu N, Szabo A, Chu T, Rhebergen A, Jairam V, Cyrus N, Brokowski C, Eisenbarth S, Phillips G, Cline G, Phillips A, Medzhitov R
Nature, 2014;513(7519):559-63.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Developmental propagation of V(D)J recombination-associated DNA breaks and translocations in mature B cells via dicentric chromosomes.
Authors: Hu, Jiazhi, Tepsuporn, Suprawee, Meyers, Robin M, Gostissa, Monica, Alt, Frederic
Proc Natl Acad Sci U S A, 2014;111(28):10269-74.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Alternative splice variants of AID are not stoichiometrically present at the protein level in chronic lymphocytic leukemia.
Authors: Rebhandl S, Huemer M, Zaborsky N, Gassner F, Catakovic K, Felder T, Greil R, Geisberger R
Eur J Immunol, 2014;44(7):2175-87.
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay

Enhancement of tumor-specific T cell-mediated immunity in dendritic cell-based vaccines by Mycobacterium tuberculosis heat shock protein X.
Authors: Jung I, Shin S, Lee M, Kang T, Han H, Lee S, Kim W, Kim H, Park W, Kim H, Yun C, Lee E, Wu T, Park Y
J Immunol, 2014;193(3):1233-45.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Macrophage PTEN regulates expression and secretion of arginase I modulating innate and adaptive immune responses.
Authors: Sahin E, Haubenwallner S, Kuttke M, Kollmann I, Halfmann A, Dohnal A, Chen L, Cheng P, Hoesel B, Einwallner E, Brunner J, Kral J, Schrottmaier W, Thell K, Saferding V, Bluml S, Schabbauer G
J Immunol, 2014;193(4):1717-27.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

IL-17A as an inducer for Th2 immune responses in murine atopic dermatitis models.
Authors: Nakajima S, Kitoh A, Egawa G, Natsuaki Y, Nakamizo S, Moniaga C, Otsuka A, Honda T, Hanakawa S, Amano W, Iwakura Y, Nakae S, Kubo M, Miyachi Y, Kabashima K
J Invest Dermatol, 2014;134(8):2122-30.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Accelerated neurodegeneration and neuroinflammation in transgenic mice expressing P301L tau mutant and tau-tubulin kinase 1.
Authors: Asai H, Ikezu S, Woodbury M, Yonemoto G, Cui L, Ikezu T
Am J Pathol, 2014;184(3):808-18.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Kruppel-like transcription factor 6 regulates inflammatory macrophage polarization.
Authors: Date D, Das R, Narla G, Simon D, Jain M, Mahabeleshwar G
J Biol Chem, 2014;289(15):10318-29.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

MHC class II transactivator is an in vivo regulator of osteoclast differentiation and bone homeostasis co-opted from adaptive immunity.
Authors: Benasciutti E, Mariani E, Oliva L, Scolari M, Perilli E, Barras E, Milan E, Orfanelli U, Fazzalari N, Campana L, Capobianco A, Otten L, Particelli F, Acha-Orbea H, Baruffaldi F, Faccio R, Sitia R, Reith W, Cenci S
J Bone Miner Res, 2014;29(2):290-303.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Binding of AID to DNA does not correlate with mutator activity.
Authors: Matthews A, Husain S, Chaudhuri J
J Immunol, 2014;193(1):252-7.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Uracil excision by endogenous SMUG1 glycosylase promotes efficient Ig class switching and impacts on A:T substitutions during somatic mutation.
Authors: Dingler F, Kemmerich K, Neuberger M, Rada C
Eur J Immunol, 2014;44(7):1925-35.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Colony-stimulating factor-1 signaling suppresses renal crystal formation.
Authors: Taguchi K, Okada A, Kitamura H, Yasui T, Naiki T, Hamamoto S, Ando R, Mizuno K, Kawai N, Tozawa K, Asano K, Tanaka M, Miyoshi I, Kohri K
J Am Soc Nephrol, 2014;25(8):1680-97.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Germinal center B cell maintenance and differentiation are controlled by distinct NF-kappaB transcription factor subunits.
Authors: Heise N, De Silva N, Silva K, Carette A, Simonetti G, Pasparakis M, Klein U
J Exp Med, 2014;211(10):2103-18.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Characterization of the structure and immunostimulatory activity of a vaccine adjuvant, de-O-acylated lipooligosaccharide.
Authors: Han, Ji Eun, Wui, Seo Ri, Kim, Kwang Su, Cho, Yang Je, Cho, Wan Je, Lee, Na Gyong
PLoS ONE, 2014;9(1):e85838.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Aging is associated with increased regulatory T-cell function.
Authors: Garg S, Delaney C, Toubai T, Ghosh A, Reddy P, Banerjee R, Yung R
Aging Cell, 2014;13(3):441-8.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Glucose-dependent de novo lipogenesis in B lymphocytes: a requirement for atp-citrate lyase in lipopolysaccharide-induced differentiation.
Authors: Dufort, Fay J, Gumina, Maria R, Ta, Nathan L, Tao, Yongzhen, Heyse, Shannon, Scott, David A, Richardson, Adam D, Seyfried, Thomas N, Chiles, Thomas C
J Biol Chem, 2014;289(10):7011-24.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Acanthamoeba protease activity promotes allergic airway inflammation via protease-activated receptor 2.
Authors: Park, Mi Kyung, Cho, Min Kyou, Kang, Shin Ae, Park, Hye-Kyun, Kim, Dong-Hee, Yu, Hak Sun
PLoS ONE, 2014;9(3):e92726.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

A role for the ITAM signaling module in specifying cytokine-receptor functions.
Authors: Bezbradica J, Rosenstein R, DeMarco R, Brodsky I, Medzhitov R
Nat Immunol, 2014;15(4):333-42.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Mouse BAZ1A (ACF1) is dispensable for double-strand break repair but is essential for averting improper gene expression during spermatogenesis.
Authors: Dowdle J, Mehta M, Kass E, Vuong B, Inagaki A, Egli D, Jasin M, Keeney S
PLoS Genet, 2013;9(11):e1003945.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Rgs13 constrains early B cell responses and limits germinal center sizes.
Authors: Hwang I, Hwang K, Park C, Harrison K, Kehrl J
PLoS ONE, 2013;8(3):e60139.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Apurinic/apyrimidinic endonuclease 1 is the essential nuclease during immunoglobulin class switch recombination.
Authors: Masani, Shahnaz, Han, Li, Yu, Kefei
Mol Cell Biol, 2013;33(7):1468-73.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Scaffold functions of 14-3-3 adaptors in B cell immunoglobulin class switch DNA recombination.
Authors: Lam T, Thomas L, White C, Li G, Pone E, Xu Z, Casali P
PLoS ONE, 2013;8(11):e80414.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

TNF-like ligand 1A (TL1A) gene knockout leads to ameliorated collagen-induced arthritis in mice: implication of TL1A in humoral immune responses.
Authors: Wang X, Hu Y, Charpentier T, Lamarre A, Qi S, Wu J, Luo H
J Immunol, 2013;191(11):5420-9.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Dissociation of endotoxin tolerance and differentiation of alternatively activated macrophages.
Authors: Rajaiah R, Perkins D, Polumuri S, Zhao A, Keegan A, Vogel S
J Immunol, 2013;190(9):4763-72.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

IL-4/IL-13-dependent and independent expression of miR-124 and its contribution to M2 phenotype of monocytic cells in normal conditions and during allergic inflammation.
Authors: Veremeyko, Tatyana, Siddiqui, Shafiudd, Sotnikov, Ilya, Yung, Amanda, Ponomarev, Eugene D
PLoS ONE, 2013;8(12):e81774.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

12/15-lipoxygenase expressed in non-epithelial cells causes airway epithelial injury in asthma.
Authors: Mabalirajan U, Rehman R, Ahmad T, Kumar S, Leishangthem G, Singh S, Dinda A, Biswal S, Agrawal A, Ghosh B
Sci Rep, 2013;3(0):1540.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Functional education of invariant NKT cells by dendritic cell tuning of SHP-1.
Authors: Napolitano, Anna, Pittoni, Paola, Beaudoin, Lucie, Lehuen, Agnes, Voehringer, David, MacDonald, H Robson, Dellabona, Paolo, Casorati, Giulia
J Immunol, 2013;190(7):3299-308.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Differential requirements of CD4(+) T-cell signals for effector cytotoxic T-lymphocyte (CTL) priming and functional memory CTL development at higher CD8(+) T-cell precursor frequency.
Authors: Umeshappa C, Nanjundappa R, Xie Y, Freywald A, Xu Q, Xiang J
Immunology, 2013;138(4):298-306.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Age- and light-dependent development of localised retinal atrophy in CCL2(-/-)CX3CR1(GFP/GFP) mice.
Authors: Chen M, Hombrebueno J, Luo C, Penalva R, Zhao J, Colhoun L, Pandi S, Forrester J, Xu H
PLoS ONE, 2013;8(4):e61381.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Antigen-specific induced T regulatory cells impair dendritic cell function via an IL-10/MARCH1-dependent mechanism.
Authors: Chattopadhyay, Gouri, Shevach, Ethan M
J Immunol, 2013;191(12):5875-84.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Inflammasome adaptor protein Apoptosis-associated speck-like protein containing CARD (ASC) is critical for the immune response and survival in west Nile virus encephalitis.
Authors: Kumar M, Roe K, Orillo B, Muruve D, Nerurkar V, Gale M, Verma S
J Virol, 2013;87(7):3655-67.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) and nuclear factor-kappaB (NF-kappaB): a feed-forward loop for systemic and vascular inflammation.
Authors: Leslie K, Song G, Barrick S, Wehbi V, Vilardaga J, Bauer P, Bisello A
J Biol Chem, 2013;288(51):36426-36.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Mycobacterium tuberculosis RpfB drives Th1-type T cell immunity via a TLR4-dependent activation of dendritic cells.
Authors: Kim J, Kim W, Choi H, Jang B, Lee K, Park J, Kim H, Cho S, Shin S
J Leukoc Biol, 2013;94(4):733-49.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

The role of Bruton's tyrosine kinase in the development and BCR/TLR-dependent activation of AM14 rheumatoid factor B cells.
Authors: Nundel K, Busto P, Debatis M, Marshak-Rothstein A
J Leukoc Biol, 2013;94(5):865-75.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Regulation of Foxp3+ inducible regulatory T cell stability by SOCS2.
Authors: Knosp C, Schiering C, Spence S, Carroll H, Nel H, Osbourn M, Jackson R, Lyubomska O, Malissen B, Ingram R, Fitzgerald D, Powrie F, Fallon P, Johnston J, Kissenpfennig A
J Immunol, 2013;190(7):3235-45.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Activated macrophages release microvesicles containing polarized M1 or M2 mRNAs.
Authors: Garzetti, Livia, Menon, Ramesh, Finardi, Annamari, Bergami, Alessand, Sica, Antonio, Martino, Gianvito, Comi, Giancarl, Verderio, Claudia, Farina, Cinthia, Furlan, Roberto
J Leukoc Biol, 2013;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Identification, characterization, and isolation of a common progenitor for osteoclasts, macrophages, and dendritic cells from murine bone marrow and periphery.
Authors: Jacome-Galarza C, Lee S, Lorenzo J, Aguila H
J Bone Miner Res, 2013;28(5):1203-13.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

The exonuclease Trex1 restrains macrophage proinflammatory activation.
Authors: Pereira-Lopes S, Celhar T, Sans-Fons G, Serra M, Fairhurst A, Lloberas J, Celada A
J Immunol, 2013;191(12):6128-35.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Prostate cancer stem cells are targets of both innate and adaptive immunity and elicit tumor-specific immune responses.
Authors: Jachetti, Elena, Mazzoleni, Stefania, Grioni, Matteo, Ricupito, Alessia, Brambillasca, Chiara, Generoso, Luca, Calcinotto, Arianna, Freschi, Massimo, Mondino, Anna, Galli, Rossella, Bellone, Matteo
Oncoimmunology, 2013;2(5):e24520.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Tetraspanin CD37 contributes to the initiation of cellular immunity by promoting dendritic cell migration.
Authors: Gartlan K, Wee J, Demaria M, Nastovska R, Chang T, Jones E, Apostolopoulos V, Pietersz G, Hickey M, van Spriel A, Wright M
Eur J Immunol, 2013;43(5):1208-19.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

p53 controls autoimmune arthritis via STAT-mediated regulation of the Th17 cell/Treg cell balance in mice.
Authors: Park J, Lim M, Cho M, Ryu J, Moon Y, Jhun J, Byun J, Kim E, Hwang S, Ju J, Kwok S, Kim H
Arthritis Rheum, 2013;65(4):949-59.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Bee venom phospholipase A2 induces a primary type 2 response that is dependent on the receptor ST2 and confers protective immunity.
Authors: Palm N, Rosenstein R, Yu S, Schenten D, Florsheim E, Medzhitov R
Immunity, 2013;39(5):976-85.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Control of T helper 2 responses by transcription factor IRF4-dependent dendritic cells.
Authors: Gao Y, Nish S, Jiang R, Hou L, Licona-Limon P, Weinstein J, Zhao H, Medzhitov R
Immunity, 2013;39(4):722-32.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Regulation of innate CD8+ T-cell activation mediated by cytokines.
Proc Natl Acad Sci U S A, 2012;109(25):9971-6.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

TNFR-Associated Factor 2 Deficiency in B Lymphocytes Predisposes to Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma in Mice.
Authors: Perez-Chacon G, Llobet D, Pardo C, Pindado J, Choi Y, Reed JC, Zapata JM
J. Immunol., 2012;189(2):1053-61.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

CCL25 induces alpha 4 beta 7 integrin-dependent migration of IL-17+ gamma/delta T lymphocytes during an allergic reaction.
Authors: Costa MF, Bornstein VU, Candea AL, Henriques-Pons A, Henriques MG, Penido C
Eur. J. Immunol., 2012;42(5):1250-60.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells.
Nat. Med., 2012;1248(0):18.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Protein kinase C delta (PKCdelta)-extracellular signal-regulated kinase 1/2 (ERK1/2) signaling cascade regulates glycogen synthase kinase-3 (GSK-3) inhibition-mediated interleukin-10 (IL-10) expression in lipopolysaccharide (LPS)-induced endotoxemia.
Authors: Noh KT, Son KH, Jung ID, Kang HK, Hwang SA, Lee WS, You JC, Park YM
J. Biol. Chem., 2012;287(17):14226-33.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Breast regression protein-39 (BRP-39) promotes dendritic cell maturation in vitro and enhances Th2 inflammation in murine model of asthma.
Authors: Xu Q, Chai S, Qian Y, Zhang M, Wang K
Acta Pharmacol Sin, 2012;33(12):1525-32.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

An epigenetic silencing pathway controlling T helper 2 cell lineage commitment.
Authors: Allan RS, Zueva E, Cammas F, Schreiber HA, Masson V, Belz GT, Roche D, Maison C, Quivy JP, Almouzni G, Amigorena S
Nature, 2012;487(7406):249-53.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Dendritic cell exosomes directly kill tumor cells and activate natural killer cells via TNF superfamily ligands.
Authors: Munich S, Sobo-Vujanovic A, Buchser W, Beer-Stolz D, Vujanovic N
Oncoimmunology, 2012;1(7):1074-1083.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

The MSHA Strain of Pseudomonas Aeruginosa Activated TLR Pathway and Enhanced HIV-1 DNA Vaccine Immunoreactivity.
Authors: Hou J, Liu Y, Liu Y, Shao Y
PLoS ONE, 2012;7(10):e47724.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

The effect of conditional EFNB1 deletion in the T cell compartment on T cell development and function.
Authors: Jin W, Qi S, Luo H
BMC Immunol., 2011;12(0):68.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

PEGylation of interleukin-10 for the mitigation of enhanced pain states.
Authors: Soderquist RG, Milligan ED, Harrison JA, Chavez RA, Johnson KW, Watkins LR, Mahoney MJ
J Biomed Mater Res A, 2010;93(3):1169-79.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

A novel role for constitutively expressed epithelial-derived chemokines as antibacterial peptides in the intestinal mucosa.
Authors: Kotarsky K, Sitnik KM, Stenstad H, Kotarsky H, Schmidtchen A, Koslowski M, Wehkamp J, Agace WW
Mucosal Immunol, 2010;3(1):40-8.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation.
Authors: Chang HC, Sehra S, Goswami R, Yao W, Yu Q, Stritesky GL, Jabeen R, McKinley C, Ahyi AN, Han L, Nguyen ET, Robertson MJ, Perumal NB, Tepper RS, Nutt SL, Kaplan MH
Nat. Immunol., 2010;11(6):527-34.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model.
Authors: Yoshizaki A, Yanaba K, Iwata Y
J. Immunol., 2010;185(4):2502-15.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus.
Authors: Kayamuro H, Yoshioka Y, Abe Y, Arita S, Katayama K, Nomura T, Yoshikawa T, Kubota-Koketsu R, Ikuta K, Okamoto S, Mori Y, Kunisawa J, Kiyono H, Itoh N, Nagano K, Kamada H, Tsutsumi Y, Tsunoda S
J. Virol., 2010;84(24):12703-12.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Oncostatin M induces dendritic cell maturation and Th1 polarization.
Authors: Jung ID, Noh KT, Lee CM, Chun SH, Jeong SK, Park JW, Park WS, Kim HW, Yun CH, Shin YK, Park YM
Biochem. Biophys. Res. Commun., 2010;394(2):272-8.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

Proinflammatory clearance of apoptotic neutrophils induces an IL-12(low)IL-10(high) regulatory phenotype in macrophages.
Authors: Filardy AA, Pires DR, Nunes MP, Takiya CM, Freire-de-Lima CG, Ribeiro-Gomes FL, DosReis GA
J. Immunol., 2010;185(4):2044-50.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Sustained signaling by canonical helper T cell cytokines throughout the reactive lymph node.
Authors: Perona-Wright G, Mohrs K, Mohrs M
Nat. Immunol., 2010;11(6):520-6.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells.
Authors: Dienz O, Eaton SM, Bond JP, Neveu W, Moquin D, Noubade R, Briso EM, Charland C, Leonard WJ, Ciliberto G, Teuscher C, Haynes L, Rincon M
J. Exp. Med., 2009;206(1):69-78.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

TLR4 ligands induce IFN-alpha production by mouse conventional dendritic cells and human monocytes after IFN-beta priming.
Authors: Richez C, Yasuda K, Watkins AA
J. Immunol., 2009;182(2):820-8.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

ST2 deficient mice display a normal host defense against pulmonary infection with Mycobacterium tuberculosis.
Authors: Wieland CW, van der Windt GJ, Florquin S, McKenzie AN, van der Poll T
Microbes Infect., 2009;11(4):524-30.

The adaptor protein CIKS/Act1 is essential for IL-25-mediated allergic airway inflammation.
Authors: Claudio E, Sonder SU, Saret S, Carvalho G, Ramalingam TR, Wynn TA, Chariot A, Garcia-Perganeda A, Leonardi A, Paun A, Chen A, Ren NY, Wang H, Siebenlist U
J. Immunol., 2009;182(3):1617-30.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

CD14 contributes to pulmonary inflammation and mortality during murine tuberculosis.
Authors: Wieland CW, van der Windt GJ, Wiersinga WJ, Florquin S, van der Poll T
Immunology, 2008;125(2):272-9.
Species: N/A
Sample Types: N/A
Applications: ELISA (Standard)

Direct B cell stimulation by dendritic cells in a mouse model of lupus.
Authors: Wan S, Zhou Z, Duan B, Morel L
Arthritis Rheum., 2008;8(0):1741-50.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Interferon-gamma limits Th1 lymphocyte adhesion to inflamed endothelium: a nitric oxide regulatory feedback mechanism.
Authors: Norman MU, Zbytnuik L, Kubes P
Eur. J. Immunol., 2008;38(5):1368-80.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

A mechanism for the initiation of allergen-induced T helper type 2 responses.
Authors: Sokol CL, Barton GM, Farr AG, Medzhitov R
Nat. Immunol., 2008;9(3):310-8.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Controlled delivery of T-box21 small interfering RNA ameliorates autoimmune alopecia (Alopecia Areata) in a C3H/HeJ mouse model.
Authors: Nakamura M, Jo J, Tabata Y, Ishikawa O
Am. J. Pathol., 2008;172(3):650-8.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice.
Authors: McKinley L, Alcorn JF, Peterson A, Dupont RB, Kapadia S, Logar A, Henry A, Irvin CG, Piganelli JD, Ray A, Kolls JK
J. Immunol., 2008;181(6):4089-97.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Adenosine receptors in regulation of dendritic cell differentiation and function.
Authors: Novitskiy SV, Ryzhov S, Zaynagetdinov R, Goldstein AE, Huang Y, Tikhomirov OY, Blackburn MR, Biaggioni I, Carbone DP, Feoktistov I, Dikov MM
Blood, 2008;112(5):1822-31.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance.
Authors: Zelante T, De Luca A, Bonifazi P, Montagnoli C, Bozza S, Moretti S, Belladonna ML, Vacca C, Conte C, Mosci P, Bistoni F, Puccetti P, Kastelein RA, Kopf M, Romani L
Eur. J. Immunol., 2007;37(10):2695-706.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

The JAK-3 inhibitor CP-690550 is a potent anti-inflammatory agent in a murine model of pulmonary eosinophilia.
Authors: Kudlacz E, Conklyn M, Andresen C, Whitney-Pickett C, Changelian P
Eur. J. Pharmacol., 2007;582(1):154-61.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Nod1-mediated innate immune recognition of peptidoglycan contributes to the onset of adaptive immunity.
Authors: Fritz JH, Le Bourhis L, Sellge G, Magalhaes JG, Fsihi H, Kufer TA, Collins C, Viala J, Ferrero RL, Girardin SE, Philpott DJ
Immunity, 2007;26(4):445-59.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

The IL-4/IL-13/Stat6 signalling pathway promotes luminal mammary epithelial cell development.
Authors: Khaled WT, Read EK, Nicholson SE, Baxter FO, Brennan AJ, Came PJ, Sprigg N, McKenzie AN, Watson CJ
Development, 2007;134(15):2739-50.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Liposomal retinoic acids modulate asthma manifestations in mice.
Authors: Maret M, Ruffie C, Periquet B, Campo AM, Menevret M, Phelep A, Dziewiszek K, Druilhe A, Pretolani M
J. Nutr., 2007;137(12):2730-6.
Species: N/A
Sample Types: N/A
Applications: ELISA (Standard)

The endothelial cell-produced antiangiogenic cytokine vascular endothelial growth inhibitor induces dendritic cell maturation.
Authors: Tian F, Grimaldo S, Fujita M, Fugita M, Cutts J, Vujanovic NL, Li LY
J. Immunol., 2007;179(6):3742-51.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Dendritic cells loaded with apoptotic antibody-coated tumor cells provide protective immunity against B-cell lymphoma in vivo.
Authors: Franki SN, Steward KK, Betting DJ, Kafi K, Yamada RE, Timmerman JM
Blood, 2007;111(3):1504-11.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Critical role of the Fc receptor gamma-chain on APCs in the development of allergen-induced airway hyperresponsiveness and inflammation.
Authors: Kitamura K, Takeda K, Koya T, Miyahara N, Kodama T, Dakhama A, Takai T, Hirano A, Tanimoto M, Harada M, Gelfand EW
J. Immunol., 2007;178(1):480-8.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Cytopiloyne, a novel polyacetylenic glucoside from Bidens pilosa, functions as a T helper cell modulator.
Authors: Chiang YM, Chang CL, Chang SL, Yang WC, Shyur LF
J Ethnopharmacol, 2007;110(3):532-8.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

In vivo blockade of OX40 ligand inhibits thymic stromal lymphopoietin driven atopic inflammation.
Authors: Seshasayee D, Lee WP, Zhou M, Shu J, Suto E, Zhang J, Diehl L, Austin CD, Meng YG, Tan M, Bullens SL, Seeber S, Fuentes ME, Labrijn AF, Graus YM, Miller LA, Schelegle ES, Hyde DM, Wu LC, Hymowitz SG, Martin F
J. Clin. Invest., 2007;117(12):3868-3878.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

T-bet inhibits both TH2 cell-mediated eosinophil recruitment and TH17 cell-mediated neutrophil recruitment into the airways.
Authors: Fujiwara M, Hirose K, Kagami S, Takatori H, Wakashin H, Tamachi T, Watanabe N, Saito Y, Iwamoto I, Nakajima H
J. Allergy Clin. Immunol., 2007;119(3):662-70.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

The 130-kDa glycoform of CD43 functions as an E-selectin ligand for activated Th1 cells in vitro and in delayed-type hypersensitivity reactions in vivo.
Authors: Alcaide P, King SL, Dimitroff CJ, Lim YC, Fuhlbrigge RC, Luscinskas FW
J. Invest. Dermatol., 2007;127(8):1964-72.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

IL-2 is essential for TGF-beta to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells.
Authors: Zheng SG, Wang J, Wang P, Gray JD, Horwitz DA
J. Immunol., 2007;178(4):2018-27.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Lentiviral vector-mediated autonomous differentiation of mouse bone marrow cells into immunologically potent dendritic cell vaccines.
Authors: Koya RC, Kimura T, Ribas A, Rozengurt N, Lawson GW, Faure-Kumar E, Wang HJ, Herschman H, Kasahara N, Stripecke R
Mol. Ther., 2007;15(5):971-80.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Interleukin-4 does not influence development of hypercholesterolemia or angiotensin II-induced atherosclerotic lesions in mice.
Authors: King VL, Cassis LA, Daugherty A
Am. J. Pathol., 2007;171(6):2040-7.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Microglia activated by IL-4 or IFN-gamma differentially induce neurogenesis and oligodendrogenesis from adult stem/progenitor cells.
Authors: Butovsky O, Ziv Y, Schwartz A, Landa G, Talpalar AE, Pluchino S, Martino G, Schwartz M
Mol. Cell. Neurosci., 2006;31(1):149-60.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

3BP2 deficiency impairs the response of B cells, but not T cells, to antigen receptor ligation.
Authors: de la Fuente MA, Kumar L, Lu B, Geha RS
Mol. Cell. Biol., 2006;26(14):5214-25.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Severe sepsis exacerbates cell-mediated immunity in the lung due to an altered dendritic cell cytokine profile.
Authors: Wen H, Hogaboam CM, Gauldie J, Kunkel SL
Am. J. Pathol., 2006;168(6):1940-50.
Species: N/A
Sample Types: N/A
Applications: ELISA (Standard)

Immunosuppressant triptolide inhibits dendritic cell-mediated chemoattraction of neutrophils and T cells through inhibiting Stat3 phosphorylation and NF-kappaB activation.
Authors: Liu Q, Chen T, Chen G, Li N, Wang J, Ma P, Cao X
Biochem. Biophys. Res. Commun., 2006;345(3):1122-30.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Activin A functions as a Th2 cytokine in the promotion of the alternative activation of macrophages.
Authors: Ogawa K, Funaba M, Chen Y, Tsujimoto M
J. Immunol., 2006;177(10):6787-94.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Induction and blockage of oligodendrogenesis by differently activated microglia in an animal model of multiple sclerosis.
Authors: Butovsky O, Landa G, Kunis G, Ziv Y, Avidan H, Greenberg N, Schwartz A, Smirnov I, Pollack A, Jung S, Schwartz M
J. Clin. Invest., 2006;116(4):905-15.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Cytokine milieu of atopic dermatitis skin subverts the innate immune response to vaccinia virus.
Authors: Howell MD, Gallo RL, Boguniewicz M, Jones JF, Wong C, Streib JE, Leung DY
Immunity, 2006;24(3):341-8.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Differential roles of vascular endothelial growth factor receptors 1 and 2 in dendritic cell differentiation.
Authors: Dikov MM, Ohm JE, Ray N, Tchekneva EE, Burlison J, Moghanaki D, Nadaf S, Carbone DP
J. Immunol., 2005;174(1):215-22.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

IL-1 mediates TNF-induced osteoclastogenesis.
Authors: Wei S, Kitaura H, Zhou P, Ross FP, Teitelbaum SL
J. Clin. Invest., 2005;115(2):282-90.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages.
Authors: Harrington, Laurie E, Hatton, Robin D, Mangan, Paul R, Turner, Henriett, Murphy, Theresa, Murphy, Kenneth, Weaver, Casey T
Nat Immunol, 2005;6(11):1123-32.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Vaccination of apoptotic Fas ligand-expressing tumors decreased antitumor responses by enhanced production of immunosuppressive cytokines.
Authors: Wada A, Tada Y, Shimozato O, Takiguchi Y, Tatsumi K, Kuriyama T, Tagawa M
Anticancer Res., 2005;25(1):299-303.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

NK cell activation by dendritic cells (DCs) requires the formation of a synapse leading to IL-12 polarization in DCs.
Authors: Borg C, Jalil A, Laderach D, Maruyama K, Wakasugi H, Charrier S, Ryffel B, Cambi A, Figdor C, Vainchenker W, Galy A, Caignard A, Zitvogel L
Blood, 2004;104(10):3267-75.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Control of Leishmania major in the absence of Tyk2 kinase.
Authors: Schleicher U, Mattner J, Blos M, Schindler H, Rollinghoff M, Karaghiosoff M, Muller M, Werner-Felmayer G, Bogdan C
Eur. J. Immunol., 2004;34(2):519-29.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Increased and long-term generation of dendritic cells with reduced function from IL-6-deficient bone marrow.
Authors: Bleier JI, Pillarisetty VG, Shah AB, DeMatteo RP
J. Immunol., 2004;172(12):7408-16.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Intracellular thiols contribute to Th2 function via a positive role in IL-4 production.
Authors: Monick MM, Samavati L, Butler NS, Mohning M, Powers LS, Yarovinsky T, Spitz DR, Hunninghake GW
J. Immunol., 2003;171(10):5107-15.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

P-selectin mediates IL-13-induced eosinophil transmigration but not eotaxin generation in vivo: a comparative study with IL-4-elicited responses.
Authors: Larbi KY, Dangerfield JP, Culley FJ, Marshall D, Haskard DO, Jose PJ, Williams TJ, Nourshargh S
J. Leukoc. Biol., 2003;73(1):65-73.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Dual roles of IL-4 in lung injury and fibrosis.
Authors: Huaux F, Liu T, McGarry B, Ullenbruch M, Phan SH
J. Immunol., 2003;170(4):2083-92.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

AMD3100, a CxCR4 antagonist, attenuates allergic lung inflammation and airway hyperreactivity.
Authors: Lukacs NW, Berlin A, Schols D, Skerlj RT, Bridger GJ
Am. J. Pathol., 2002;160(4):1353-60.
Species: N/A
Sample Types: N/A
Applications: ELISA (Standard)

Cytokine production by mouse myeloid dendritic cells in relation to differentiation and terminal maturation induced by lipopolysaccharide or CD40 ligation.
Authors: Morelli AE, Zahorchak AF, Larregina AT
Blood, 2001;98(5):1512-23.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

The IL-6 family cytokines, interleukin-6, interleukin-11, oncostatin M, and leukemia inhibitory factor, enhance mast cell growth through fibroblast-dependent pathway in mice.
Authors: Gyotoku E, Morita E, Kameyoshi Y, Hiragun T, Yamamoto S, Hide M
Arch. Dermatol. Res., 2001;293(10):508-14.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Antibodies to vascular endothelial growth factor enhance the efficacy of cancer immunotherapy by improving endogenous dendritic cell function.
Authors: Gabrilovich DI, 2018, Ishida T, Nadaf S, Ohm JE, Carbone DP
1537, 1999;5(10):2963-70.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Human macrophages induce CD4(+)Foxp3(+) regulatory T cells via binding and re-release of TGF-beta.
Authors: Schmidt A, Zhang X, Joshi R, Iqbal S, Wahlund C, Gabrielsson S, Harris R, Tegner J
Immunol Cell Biol, 0;94(8):747-62.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

FAQs

Has recombinant mouse IL-4, Catalog # 404-ML, been tested for activity on human cells?
- We have not evaluated the bioactivity of Recombinant Mouse IL-4 Protein (Catalog # 404-ML) with human cells. However, we recommend reviewing our list of publications under the Citations tab on the product web page to find reported use of this product with human cells. We do offer a Recombinant Human IL-4 Protein (Catalog # 204-IL), which is suitable for use with human cells.
What concentration of recombinant mouse IL-4, Catalog # 404-ML, should I use for my cell culture experiment?
- We evaluate the bioactivity of Recombinant Mouse IL-4 Protein (Catalog # 404-ML) in a cell proliferation assay using M‑NFS‑60 mouse myelogenous leukemia lymphoblast cells. The ED50 for this effect is 0.5-1.5 ng/mL. This ED50 range can provide a starting point for your experiment, but we would recommend end-users perform a dose-response to determine the best concentration for their assay system. We also recommend reviewing our list of publications under the Citations tab on the product-specific web page to find reported use of our products in similar experimental layouts.

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Reviews for Recombinant Mouse IL-4 Protein

Average Rating: 4.8 (Based on 9 Reviews)

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