Recombinant Mouse IL-4 Protein

  (233 citations)
(5 Reviews)
    
Datasheet / CoA / SDS
Product Details
Citations (233)
FAQs
Reviews
  • Purity
    >97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
  • Endotoxin Level
    <0.10 EU per 1 μg of the protein by the LAL method.
  • Activity
    Measured in a cell proliferation assay using HT‑2 mouse T cells. The ED50 for this effect is 0.3‑1.5 ng/mL.
  • Source
    E. coli-derived mouse IL-4 protein
    His23-Ser140, with an N-terminal Met
  • Accession #
  • N-terminal Sequence
    Analysis
    His23
  • Predicted Molecular Mass
    14 kDa
Product Datasheets

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Carrier Free
What does CF mean?
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
What formulation is right for me?
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
404-ML
 
404-ML/CF
Formulation Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein. *1 mg pack size (01M) is supplied as a 0.2 µm filtered solution in PBS with BSA as a carrier protein.
 
Formulation Lyophilized from a 0.2 μm filtered solution in PBS. *1 mg pack size (01M) is supplied as a 0.2 µm filtered solution in PBS.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
 
Reconstitution Reconstitute at 100 μg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
 
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
 
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Data Images
Recombinant Mouse IL-4 (Catalog # 404‑ML) stimulates cell proliferation of the HT‑2 mouse T cell line. The ED50 for this effect is 0.3-1.5 ng/mL.
1 μg/lane of Recombinant Mouse IL-4 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 12 kDa.
Background: IL-4

Interleukin-4 (IL-4), also known as B cell-stimulatory factor-1, is a monomeric, approximately 13 kDa-18 kDa Th2 cytokine that shows pleiotropic effects during immune responses (1-4). It is a glycosylated polypeptide that contains three intrachain disulfide bridges and adopts a bundled four alpha -helix structure (5). Mouse IL-4 is synthesized with a 24 aa signal sequence. Mature mouse IL-4 shares 39%, 39%, and 59% aa sequence identity with bovine, human, and rat IL-4, respectively. Human, mouse, and rat IL-4 are species-specific in their activities (6-8). IL-4 exerts its effects through two receptor complexes (9, 10). The type I receptor, which is expressed on hematopoietic cells, is a heterodimer of the ligand binding IL-4 R alpha and the common gamma chain (a shared subunit of the receptors for IL-2, -7, -9, -15, and
-21). The type II receptor on nonhematopoietic cells consists of IL‑4 R alpha and IL‑13 R alpha 1. The type II receptor also transduces IL‑13 mediated signals. IL-4 is primarily expressed by Th2‑biased CD4+ T cells, mast cells, basophils, and eosinophils (1, 2). It promotes cell proliferation, survival, and immunoglobulin class switch to IgG1 and IgE in mouse B cells, acquisition of the Th2 phenotype by naïve CD4+ T cells, priming and chemotaxis of mast cells, eosinophils, and basophils, and the proliferation and activation of epithelial cells (11 ‑ 14). IL-4 plays a dominant role in the development of allergic inflammation and asthma (13, 15).

  • References:
    1. Benczik, M. and S.L. Gaffen (2004) Immunol. Invest. 33:109.
    2. Chomarat, P. and J. Banchereau (1998) Int. Rev. Immunol. 17:1.
    3. Lee, F. et al. (1986) Proc. Natl. Acad. Sci. 83:2061.
    4. Noma, Y. et al. (1986) Nature 319:640.
    5. Redfield, C. et al. (1991) Biochemistry 30:11029.
    6. Ramirez, F. et al. (1988) J. Immunol. Meth. 221:141.
    7. Leitenberg, D. and T.L. Feldbush (1988) Cell. Immunol. 111:451.
    8. Mosman, T.R. et al. (1987) J. Immunol. 138:1813.
    9. Mueller, T.D. et al. (2002) Biochim. Biophys. Acta 1592:237.
    10. Nelms, K. et al. (1999) Annu. Rev. Immunol. 17:701.
    11. Paludan, S.R. (1998) Scand. J. Immunol. 48:459.
    12. Corthay, A. (2006) Scand. J. Immunol. 64:93.
    13. Ryan, J.J. et al. (2007) Crit. Rev. Immunol. 27:15.
    14. Grone, A. (2002) Vet. Immunol. Immunopathol. 88:1.
    15. Rosenberg, H.F. et al. (2007) J. Allergy Clin. Immunol. 119:1303.
  • Long Name:
    Interleukin 4
  • Entrez Gene IDs:
    3565 (Human); 16189 (Mouse); 287287 (Rat); 397225 (Porcine); 280824 (Bovine); 403785 (Canine); 574281 (Primate); 100302454 (Rabbit)
  • Alternate Names:
    B cell growth factor 1; BCDF; B-cell stimulatory factor 1; BCGF1; BCGF-1; binetrakin; BSF1; BSF-1; IL4; IL-4; IL-4B_cell stimulatory factor 1; interleukin 4; interleukin-4; Lymphocyte stimulatory factor 1; MGC79402; pitrakinra
Related Research Areas
Citations:

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

233 Citations: Showing 1 - 10
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Species
Applications
Sample Type
  1. B cell activation and plasma cell differentiation are inhibited by de novo DNA methylation
    Authors: BG Barwick, CD Scharer, RJ Martinez, MJ Price, AN Wein, RR Haines, APR Bally, JE Kohlmeier, JM Boss
    Nat Commun, 2018;9(1):1900.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  2. Interleukin 4 modulates microglia homeostasis and attenuates the early slowly progressive phase of amyotrophic lateral sclerosis
    Authors: C Rossi, M Cusimano, M Zambito, A Finardi, A Capotondo, JM Garcia-Man, G Comi, R Furlan, G Martino, L Muzio
    Cell Death Dis, 2018;9(2):250.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  3. HEPES activates a MiT/TFE-dependent lysosomal-autophagic gene network in cultured cells: A call for caution
    Authors: MJ Tol, MJC van der Li, TL Gabriel, JJ Hagen, S Scheij, T Veenendaal, J Klumperman, WE Donker-Koo, AJ Verhoeven, H Overkleeft, JM Aerts, CA Argmann, M van Eijk
    Autophagy, 2018;0(0):1-13.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  4. Crucial role of OX40/OX40L signaling in a murine model of asthma
    Authors: W Lei, D Zeng, G Liu, Y Zhu, J Wang, H Wu, J Jiang, J Huang
    Mol Med Rep, 2018;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  5. The Esophageal Organoid System Reveals Functional Interplay Between Notch and Cytokines in Reactive Epithelial�Changes
    Authors: Y Kasagi, PM Chandramou, KA Whelan, K Tanaka, V Giroux, M Sharma, J Wang, AJ Benitez, M DeMarshall, JW Tobias, KE Hamilton, GW Falk, JM Spergel, AJ Klein-Szan, AK Rustgi, AB Muir, H Nakagawa
    Cell Mol Gastroenterol Hepatol, 2018;5(3):333-352.
    Species: Mouse
    Sample Type: Organoids
    Application: Bioassay
  6. Mesenchymal stem cells ameliorate experimental arthritis via expression of interleukin-1 receptor antagonist
    Authors: K Lee, N Park, H Jung, YA Rim, Y Nam, J Lee, SH Park, JH Ju
    PLoS ONE, 2018;13(2):e0193086.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  7. A new RelB-dependent CD117+CD172a+murine dendritic cell subset preferentially induces Th2 differentiation and supports airway hyperresponses in vivo
    Authors: N Andreas, M Riemann, CN Castro, M Groth, I Koliesnik, C Engelmann, T Sparwasser, T Kamradt, R Haenold, F Weih
    Eur. J. Immunol., 2018;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  8. The H2B deubiquitinase Usp22 promotes antibody class switch recombination by facilitating non-homologous end joining
    Authors: C Li, T Irrazabal, CC So, M Berru, L Du, E Lam, AK Ling, JL Gommerman, Q Pan-Hammar, A Martin
    Nat Commun, 2018;9(1):1006.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  9. Characterization and allergic role of IL-33-induced neutrophil polarization
    Authors: B Sun, L Zhu, Y Tao, HX Sun, Y Li, P Wang, Y Hou, Y Zhao, X Zhang, L Zhang, N Na, Y Zhao
    Cell. Mol. Immunol., 2018;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  10. ?M?2Is Antiatherogenic in Female but Not Male Mice
    Authors: D Szpak, L Izem, D Verbovetsk, DA Soloviev, VP Yakubenko, E Pluskota
    J. Immunol., 2018;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  11. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage
    Authors: S Nowsheen, K Aziz, A Aziz, M Deng, B Qin, K Luo, KB Jeganathan, H Zhang, T Liu, J Yu, Y Deng, J Yuan, W Ding, JM van Deurse, Z Lou
    Nat. Cell Biol., 2018;20(4):455-464.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  12. Plasma cell differentiation is controlled by multiple cell division-coupled epigenetic programs
    Authors: CD Scharer, BG Barwick, M Guo, APR Bally, JM Boss
    Nat Commun, 2018;9(1):1698.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  13. Cancer-derived Circulating MicroRNAs Promote Tumor Angiogenesis by Entering Dendritic Cells to Degrade Highly Complementary MicroRNAs
    Authors: J Wang, H Ye, D Zhang, K Cheng, Y Hu, X Yu, L Lu, J Hu, C Zuo, B Qian, Y Yu, S Liu, G Liu, C Mao, S Liu
    Theranostics, 2017;7(6):1407-1421.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  14. The transcriptional coactivator TAZ regulates reciprocal differentiation of TH17 cells and Treg cells
    Authors: J Geng, S Yu, H Zhao, X Sun, X Li, P Wang, X Xiong, L Hong, C Xie, J Gao, Y Shi, J Peng, RL Johnson, N Xiao, L Lu, J Han, D Zhou, L Chen
    Nat. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  15. miR-181a and miR-150 regulate dendritic cell immune inflammatory responses and cardiomyocyte apoptosis via targeting JAK1-STAT1/c-Fos pathway
    Authors: J Zhu, K Yao, J Guo, H Shi, L Ma, Q Wang, H Liu, W Gao, A Sun, Y Zou, J Ge
    J. Cell. Mol. Med., 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  16. Balanced Bcl-3 expression in murine CD4(+) T cells is required for generation of encephalitogenic Th17 cells
    Authors: IA Mufazalov, J Kuschmann, D Andruszews, J Masri, LA Gabriel, P Adams, S Reissig, N Hövelmeyer, A Waisman
    Eur. J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  17. Proof-of-Concept Gene Editing for the Murine Model of Inducible Arginase-1 Deficiency
    Authors: YY Sin, PR Price, LL Ballantyne, CD Funk
    Sci Rep, 2017;7(1):2585.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  18. TLR7 Signaling Regulates Th17 Cells and Autoimmunity: Novel Potential for Autoimmune Therapy
    Authors: J Ye, Y Wang, X Liu, L Li, A Opejin, EC Hsueh, H Luo, T Wang, D Hawiger, G Peng
    J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  19. IL-4-secreting eosinophils promote endometrial stromal cell proliferation and prevent Chlamydia-induced upper genital tract damage
    Authors: RD Vicetti Mi, NE Quispe Cal, D Dixon, RA Foster, A Gambotto, SD Pavelko, L Hall-Stood, TL Cherpes
    Proc. Natl. Acad. Sci. U.S.A., 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  20. IL-4 upregulates cyclooxygenase-1 expression in macrophages
    Authors: AE Shay, BT Diwakar, BJ Guan, V Narayan, JF Urban, KS Prabhu
    J. Biol. Chem., 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  21. Enhancement of antitumor immunity by combination of anti-CTLA-4 antibody and radioimmunotherapy through the suppression of Tregs
    Authors: CH Son, J Bae, HR Lee, K Yang, YS Park
    Oncol Lett, 2017;13(5):3781-3786.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  22. IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population
    Authors: DC Nascimento, PH Melo, AR Piñeros, RG Ferreira, DF Colón, PB Donate, FV Castanheir, A Gozzi, PG Czaikoski, W Niedbala, MC Borges, DS Zamboni, FY Liew, FQ Cunha, JC Alves-Filh
    Nat Commun, 2017;8(0):14919.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  23. Lamtor1 Is Critically Required for CD4(+) T Cell Proliferation and Regulatory T Cell Suppressive Function
    Authors: T Hosokawa, T Kimura, S Nada, T Okuno, D Ito, S Kang, S Nojima, K Yamashita, T Nakatani, Y Hayama, Y Kato, Y Kinehara, M Nishide, N Mikami, S Koyama, H Takamatsu, D Okuzaki, N Ohkura, S Sakaguchi, M Okada, A Kumanogoh
    J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  24. The Small Rho GTPase TC10 Modulates B Cell Immune Responses
    Authors: M Burbage, SJ Keppler, B Montaner, PK Mattila, FD Batista
    J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  25. Soluble TNF Regulates TACE via AP-2? Transcription Factor in Mouse Dendritic Cells
    Authors: L Ge, NL Vujanovic
    J. Immunol., 2017;198(1):417-427.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  26. The non-canonical poly(A) polymerase FAM46C acts as an onco-suppressor in multiple myeloma
    Authors: S Mroczek, J Chlebowska, TM Kuli?ski, O Gewartowsk, J Gruchota, D Cysewski, V Liudkovska, E Borsuk, D Nowis, A Dziembowsk
    Nat Commun, 2017;8(1):619.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  27. Mouse model of Epstein-Barr virus LMP1- and LMP2A-driven germinal center B-cell lymphoproliferative disease
    Authors: T Minamitani, Y Ma, H Zhou, H Kida, CY Tsai, M Obana, D Okuzaki, Y Fujio, A Kumanogoh, B Zhao, H Kikutani, E Kieff, BE Gewurz, T Yasui
    Proc. Natl. Acad. Sci. U.S.A, 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  28. Identification of Novel STAT6-Regulated Proteins in Mouse B Cells by Comparative Transcriptome and Proteome Analysis
    Authors: L Mokada-Gop, A Boeser, CH Lehmann, F Drepper, D Dudziak, B Warscheid, D Voehringer
    J. Immunol, 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  29. TIRR regulates 53BP1 by masking its histone methyl-lysine binding function
    Authors: P Drané, ME Brault, G Cui, K Meghani, S Chaubey, A Detappe, N Parnandi, Y He, XF Zheng, MV Botuyan, A Kalousi, WT Yewdell, C Münch, JW Harper, J Chaudhuri, E Soutoglou, G Mer, D Chowdhury
    Nature, 2017;543(7644):211-216.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  30. Opposing macrophage polarization programs show extensive epigenomic and transcriptional cross-talk
    Authors: V Piccolo, A Curina, M Genua, S Ghisletti, M Simonatto, A Sabò, B Amati, R Ostuni, G Natoli
    Nat. Immunol, 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  31. Rad52 competes with Ku70/Ku86 for binding to S-region DSB ends to modulate antibody class-switch DNA recombination
    Authors: H Zan, C Tat, Z Qiu, JR Taylor, JA Guerrero, T Shen, P Casali
    Nat Commun, 2017;8(0):14244.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  32. PEDF mediates pathological neovascularization by regulating macrophage recruitment and polarization in the mouse model of oxygen-induced retinopathy
    Authors: S Gao, C Li, Y Zhu, Y Wang, A Sui, Y Zhong, B Xie, X Shen
    Sci Rep, 2017;7(0):42846.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  33. Robust growth of avirulent phase II Coxiella burnetii in bone marrow-derived murine macrophages
    Authors: DC Cockrell, CM Long, SJ Robertson, JG Shannon, HE Miller, L Myers, CL Larson, T Starr, PA Beare, RA Heinzen
    PLoS ONE, 2017;12(3):e0173528.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  34. The Crebbp Acetyltransferase is a Haploinsufficient Tumor Suppressor in B Cell Lymphoma
    Authors: J Zhang, S Vlasevska, VA Wells, S Nataraj, AB Holmes, R Duval, SN Meyer, T Mo, K Basso, PK Brindle, S Hussein, R Dalla-Fave, L Pasqualucc
    Cancer Discov, 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  35. The PSMP-CCR2 interactions trigger monocyte/macrophage-dependent colitis
    Authors: X Pei, D Zheng, S She, J Ma, C Guo, X Mo, Y Zhang, Q Song, Y Zhang, D Ma, Y Wang
    Sci Rep, 2017;7(1):5107.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  36. Preferred M2 Polarization by ASC-Based Hydrogel Accelerated Angiogenesis and Myogenesis in Volumetric Muscle Loss Rats
    Authors: H Huang, J Liu, H Hao, D Chen, L Zhizhong, M Li, H Song, R Xiang, C Jiang, X Fu, W Han
    Stem Cells Int, 2017;2017(0):2896874.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  37. Selective degradation of PU.1 during autophagy represses the differentiation and antitumour activity of TH9 cells
    Authors: T Rivera Var, Z Cai, Y Shen, M Dosset, I Benoit-Liz, T Martin, A Roussey, RA Flavell, F Ghiringhel, L Apetoh
    Nat Commun, 2017;8(1):559.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  38. Utilization of host polyamines in alternatively activated macrophages promotes chronic infection by Brucella abortus
    Authors: T Kerrinnes, MG Winter, BM Young, VE Diaz-Ochoa, SE Winter, RM Tsolis
    Infect. Immun., 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  39. The RNA Exosome Syncs IAV-RNAPII Transcription to Promote Viral Ribogenesis and Infectivity
    Authors: A Rialdi, J Hultquist, D Jimenez-Mo, Z Peralta, L Campisi, R Fenouil, N Moshkina, ZZ Wang, B Laffleur, RM Kaake, MJ McGregor, K Haas, E Pefanis, RA Albrecht, L Pache, S Chanda, J Jen, J Ochando, M Byun, U Basu, A García-Sas, N Krogan, H van Bakel, I Marazzi
    Cell, 2017;169(4):679-692.e14.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  40. Nuclear Proximity of Mtr4 to RNA Exosome Restricts DNA Mutational Asymmetry
    Authors: J Lim, PK Giri, D Kazadi, B Laffleur, W Zhang, V Grinstein, E Pefanis, LM Brown, E Ladewig, O Martin, Y Chen, R Rabadan, F Boyer, G Rothschild, M Cogné, E Pinaud, H Deng, U Basu
    Cell, 2017;169(3):523-537.e15.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  41. Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma
    Authors: DK Chiu, AP Tse, IM Xu, J Di Cui, RK Lai, LL Li, HY Koh, FH Tsang, LL Wei, CM Wong, IO Ng, CC Wong
    Nat Commun, 2017;8(1):517.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  42. Therapeutic reversal of food allergen sensitivity by mature retinoic acid-differentiated dendritic cell induction of LAG3(+)CD49b(-)Foxp3(-) regulatory T�cells
    Authors: W Dawicki, C Li, J Town, X Zhang, JR Gordon
    J. Allergy Clin. Immunol., 2017;139(5):1608-1620.e3.
    Species: Mouse
    Sample Type: Serum
    Application: ELISA Standard
  43. CD11b regulates antibody class switching via induction of AID
    Authors: S Park, H Sim, HI Kim, D Jeong, G Wu, SY Cho, YS Lee, HJ Kwon, K Lee
    Mol. Immunol., 2017;87(0):47-59.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  44. mTORC2 controls Th9 polarization and allergic airway inflammation
    Authors: H Chen, L Zhang, P Wang, H Su, W Wang, Z Chu, L Zhang, X Zhang, Y Zhao
    Allergy, 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  45. Pro-inflammatory M1 macrophages promote osteogenesis by mesenchymal stem cells via the COX-2-prostaglandin E2 pathway
    Authors: LY Lu, F Loi, K Nathan, TH Lin, J Pajarinen, E Gibon, A Nabeshima, L Cordova, E Jämsen, Z Yao, SB Goodman
    J. Orthop. Res, 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  46. Crosstalk between glucocorticoids and IL-4 modulates Ym1 expression in alternatively activated myeloid cells
    Authors: N Ng Kuet Le, F Brombacher, AH Dalpke, M Weitnauer
    Immunobiology, 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  47. Suppression of Th17 cell differentiation by misshapen/NIK-related kinase MINK1
    Authors: G Fu, Q Xu, Y Qiu, X Jin, T Xu, S Dong, J Wang, Y Ke, H Hu, X Cao, D Wang, H Cantor, X Gao, L Lu
    J. Exp. Med., 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  48. Environmental sensing by mature B cells is controlled by the transcription factors PU.1 and SpiB
    Authors: SN Willis, J Tellier, Y Liao, S Trezise, A Light, K O'Donnell, LA Garrett-Si, W Shi, DM Tarlinton, SL Nutt
    Nat Commun, 2017;8(1):1426.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  49. Integrated STAT3 and Ikaros Zinc Finger Transcription Factor Activities Regulate Bcl-6 Expression in CD4(+) Th Cells
    Authors: KA Read, MD Powell, CE Baker, BK Sreekumar, VM Ringel-Sca, H Bachus, RE Martin, ID Cooley, IC Allen, A Ballestero, KJ Oestreich
    J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  50. Detection of immune responses after immunotherapy in glioblastoma using PET and MRI
    Authors: JP Antonios, H Soto, RG Everson, DL Moughon, AC Wang, J Orpilla, C Radu, BM Ellingson, JT Lee, T Cloughesy, ME Phelps, J Czernin, LM Liau, RM Prins
    Proc. Natl. Acad. Sci. U.S.A., 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  51. Bone-induced expression of integrin ?3 enables targeted nanotherapy of breast cancer metastases
    Authors: MH Ross, AK Esser, GC Fox, AH Schmieder, X Yang, G Hu, D Pan, X Su, Y Xu, DV Novack, T Walsh, GA Colditz, GH Lukaszewic, E Cordell, JS Novack, JAJ Fitzpatric, DL Waning, KS Mohammad, TA Guise, GM Lanza, KN Weilbaeche
    Cancer Res., 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  52. Interleukin 4 receptor-targeted pro-apoptotic peptide blocks tumor growth and metastasis by enhancing anti-tumor immunity
    Authors: SMP Vadevoo, JE Kim, GR Gunassekar, HK Jung, L Chi, DE Kim, SH Lee, SH Im, B Lee
    Mol. Cancer Ther., 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  53. Endothelium-derived extracellular vesicles promote splenic monocyte mobilization in myocardial infarction
    Authors: N Akbar, JE Digby, TJ Cahill, AN Tavare, AL Corbin, S Saluja, S Dawkins, L Edgar, N Rawlings, K Ziberna, E McNeill,, E Johnson, AA Aljabali, RA Dragovic, M Rohling, TG Belgard, IA Udalova, DR Greaves, KM Channon, PR Riley, DC Anthony, RP Choudhury
    JCI Insight, 2017;2(17):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  54. IRF-8 regulates expansion of myeloid-derived suppressor cells and Foxp3+ regulatory T cells and modulates Th2 immune responses to gastrointestinal nematode infection
    Authors: RM Valanparam, M Tam, PP Gros, JP Auger, M Segura, P Gros, A Jardim, TG Geary, K Ozato, MM Stevenson
    PLoS Pathog., 2017;13(10):e1006647.
    Species: Mouse
    Sample Type: Recombinant Protein
    Application: ELISA Standard
  55. Liraglutide dictates macrophage phenotype in apolipoprotein E null mice during early atherosclerosis
    Authors: R Bruen, S Curley, S Kajani, D Crean, ME O'Reilly, MB Lucitt, CG Godson, FC McGillicud, O Belton
    Cardiovasc Diabetol, 2017;16(1):143.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  56. Role of interleukin-4, the chemokine CCL3 and its receptor CCR5 in neuropathic pain
    Mol Immunol, 2016;77(0):184-192.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  57. Toll/Interleukin-1 Receptor Domain Derived from TcpC (TIR-TcpC) Ameliorates Experimental Autoimmune Arthritis by Down-modulating Th17 Cell Response
    Authors: Shweta Pasi
    J Biol Chem, 2016;291(23):12358-69.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  58. Alpha 1 Antitrypsin Inhibits Dendritic Cell Activation and Attenuates Nephritis in a Mouse Model of Lupus
    Authors: Ahmed S Elshikha
    PLoS ONE, 2016;11(5):e0156583.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  59. Usp9X Is Required for Lymphocyte Activation and Homeostasis through Its Control of ZAP70 Ubiquitination and PKC? Kinase Activity
    Authors: E Naik, VM Dixit
    J Immunol, 2016;196(8):3438-51.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  60. M2-polarized macrophages contribute to neovasculogenesis, leading to relapse of oral cancer following radiation
    Authors: Makiko Okubo
    Sci Rep, 2016;6(0):27548.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  61. A Lipid Based Antigen Delivery System Efficiently Facilitates MHC Class-I Antigen Presentation in Dendritic Cells to Stimulate CD8(+) T Cells
    Authors: Mithun Maji
    Sci Rep, 2016;6(0):27206.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  62. Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription
    Nat Commun, 2016;7(0):11624.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  63. Elastin-Derived Peptides Promote Abdominal Aortic Aneurysm Formation by Modulating M1/M2 Macrophage Polarization
    J Immunol, 2016;196(11):4536-43.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  64. IL-12p40/IL-10 Producing preCD8?/Clec9A+ Dendritic Cells Are Induced in Neonates upon Listeria monocytogenes Infection
    Authors: D Torres, A Köhler, S Delbauve, I Caminschi, MH Lahoud, K Shortman, V Flamand
    PLoS Pathog, 2016;12(4):e1005561.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  65. Blockade of Extracellular ATP Effect by Oxidized ATP Effectively Mitigated Induced Mouse Experimental Autoimmune Uveitis (EAU)
    PLoS ONE, 2016;11(5):e0155953.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  66. Identification and Function of Fibrocytes in Skeletal Muscle Injury Repair and Muscular Dystrophy
    J. Immunol., 2016;197(12):4750-4761.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  67. Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status
    Circ Res, 2016;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  68. Polarization of macrophages towards M2 phenotype is favored by reduction in iPLA2?
    J Biol Chem, 2016;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  69. Interferon regulatory factor 4 (IRF4) controls myeloid-derived suppressor cell (MDSC) differentiation and function
    J Leukoc Biol, 2016;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  70. Kin17 facilitates multiple double-strand break repair pathways that govern B cell class switching
    Sci Rep, 2016;6(0):37215.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  71. Epithelia Use Butyrophilin-like Molecules to Shape Organ-Specific ?? T Cell Compartments
    Authors: R Di Marco B, NA Roberts, RJ Dart, P Vantourout, A Jandke, O Nussbaumer, L Deban, S Cipolat, R Hart, ML Iannitto, A Laing, B Spencer-De, P East, D Gibbons, PM Irving, P Pereira, U Steinhoff, A Hayday
    Cell, 2016;167(1):203-218.e17.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  72. Egr2 and Egr3 in regulatory T cells cooperatively control systemic autoimmunity through Ltbp3-mediated TGF-?3 production
    Proc. Natl. Acad. Sci. U.S.A., 2016;113(50):E8131-E8140.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  73. Pharmacologic modulation of ROR?t translates to efficacy in preclinical and translational models of psoriasis and inflammatory arthritis
    Sci Rep, 2016;6(0):37977.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  74. p(70S6K1) in the TORC1 pathway is essential for the differentiation of Th17 Cells, but not Th1, Th2, or Treg cells in mice.
    Authors: Sasaki C, Chen G, Munk R, Eitan E, Martindale J, Longo D, Ghosh P
    Eur J Immunol, 2016;46(1):212-22.
  75. Intrinsic transcriptional heterogeneity in B cells controls early class switching to IgE
    Authors: Yee Ling Wu
    J. Exp. Med, 2016;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  76. VISTA deficiency accelerates the development of fatal murine lupus nephritis
    Authors: Sabrina Ceeraz
    Arthritis & rheumatology (Hoboken, N.J.), 2016;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  77. The aryl hydrocarbon receptor controls cell-fate decisions in B cells
    Authors: Bharat Vaidyanath
    J. Exp. Med, 2016;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  78. Cutting Edge: Marginal Zone Macrophages Regulate Antigen Transport by B Cells to the Follicle in the Spleen via CD21
    J Immunol, 2016;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  79. Conditioned Medium from the Stem Cells of Human Exfoliated Deciduous Teeth Ameliorates Experimental Autoimmune Encephalomyelitis
    Authors: C Shimojima, H Takeuchi, S Jin, B Parajuli, H Hattori, A Suzumura, H Hibi, M Ueda, A Yamamoto
    J Immunol, 2016;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  80. Inhibition of Ca2+-independent phospholipase A2beta (iPLA2beta) ameliorates islet infiltration and incidence of diabetes in NOD mice.
    Authors: Bone R, Gai Y, Magrioti V, Kokotou M, Ali T, Lei X, Tse H, Kokotos G, Ramanadham S
    Diabetes, 2015;64(2):541-54.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  81. Novel mechanism of macrophage-mediated metastasis revealed in a zebrafish model of tumor development.
    Authors: Wang J, Cao Z, Zhang X, Nakamura M, Sun M, Hartman J, Harris R, Sun Y, Cao Y
    Cancer Res, 2015;75(2):306-15.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  82. Protease activity of Per a 10 potentiates Th2 polarization by increasing IL-23 and OX40L.
    Authors: Agrawal K, Kale S, Arora N
    Eur J Immunol, 2015;45(12):3375-85.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  83. CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production.
    Authors: Khairnar V, Duhan V, Maney S, Honke N, Shaabani N, Pandyra A, Seifert M, Pozdeev V, Xu H, Sharma P, Baldin F, Marquardsen F, Merches K, Lang E, Kirschning C, Westendorf A, Haussinger D, Lang F, Dittmer U, Kuppers R, Recher M, Hardt C, Scheffrahn I, Beauchemin N, Gothert J, Singer B, Lang P, Lang K
    Nat Commun, 2015;6(0):6217.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  84. Radiation-driven lipid accumulation and dendritic cell dysfunction in cancer.
    Authors: Gao F, Liu C, Guo J, Sun W, Xian L, Bai D, Liu H, Cheng Y, Li B, Cui J, Zhang C, Cai J
    Sci Rep, 2015;5(0):9613.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  85. Determining the role of IL-4 induced neuroinflammation in microglial activity and amyloid-beta using BV2 microglial cells and APP/PS1 transgenic mice.
    Authors: Latta C, Sudduth T, Weekman E, Brothers H, Abner E, Popa G, Mendenhall M, Gonzalez-Oregon F, Braun K, Wilcock D
    J Neuroinflammation, 2015;12(0):41.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  86. The cholesterol transporter ABCG1 links cholesterol homeostasis and tumour immunity.
    Authors: Sag D, Cekic C, Wu R, Linden J, Hedrick C
    Nat Commun, 2015;6(0):6354.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  87. An essential role for RGS protein/Galphai2 interactions in B lymphocyte-directed cell migration and trafficking.
    Authors: Hwang I, Park C, Harrison K, Boularan C, Gales C, Kehrl J
    J Immunol, 2015;194(5):2128-39.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  88. Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells.
    Authors: Rutz S, Kayagaki N, Phung Q, Eidenschenk C, Noubade R, Wang X, Lesch J, Lu R, Newton K, Huang O, Cochran A, Vasser M, Fauber B, DeVoss J, Webster J, Diehl L, Modrusan Z, Kirkpatrick D, Lill J, Ouyang W, Dixit V
    Nature, 2015;518(7539):417-21.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  89. LKB1 inhibition of NF-kappaB in B cells prevents T follicular helper cell differentiation and germinal center formation.
    Authors: Walsh N, Waters L, Fowler J, Lin M, Cunningham C, Brooks D, Rehg J, Morse H, Teitell M
    EMBO Rep, 2015;16(6):753-68.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  90. The generation of macrophages with anti-inflammatory activity in the absence of STAT6 signaling.
    Authors: Fleming B, Chandrasekaran P, Dillon L, Dalby E, Suresh R, Sarkar A, El-Sayed N, Mosser D
    J Leukoc Biol, 2015;98(3):395-407.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  91. Exploitation of the Polymeric Immunoglobulin Receptor for Antibody Targeting to Renal Cyst Lumens in Polycystic Kidney Disease.
    Authors: Olsan E, Matsushita T, Rezaei M, Weimbs T
    J Biol Chem, 2015;290(25):15679-86.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  92. mTORC2 Deficiency in Myeloid Dendritic Cells Enhances Their Allogeneic Th1 and Th17 Stimulatory Ability after TLR4 Ligation In Vitro and In Vivo.
    Authors: Raich-Regue D, Rosborough B, Watson A, McGeachy M, Turnquist H, Thomson A
    J Immunol, 2015;194(10):4767-76.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  93. Sca-1+Lin-CD117- mesenchymal stem/stromal cells induce the generation of novel IRF8-controlled regulatory dendritic cells through Notch-RBP-J signaling.
    Authors: Liu X, Ren S, Ge C, Cheng K, Zenke M, Keating A, Zhao R
    J Immunol, 2015;194(9):4298-308.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  94. Conditional IL-4/IL-13-deficient mice reveal a critical role of innate immune cells for protective immunity against gastrointestinal helminths.
    Authors: Oeser K, Schwartz C, Voehringer D
    Mucosal Immunol, 2015;8(3):672-82.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  95. Essential engagement of Toll-like receptor 2 in initiation of early protective Th1 response against rough variants of Mycobacterium abscessus.
    Authors: Kim J, Kang M, Kim W, Han S, Kim H, Kim H, Kwon K, Kim S, Cha S, Eum S, Koh W, Cho S, Park J, Shin S
    Infect Immun, 2015;83(4):1556-67.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  96. Lymphocytes from chronically stressed mice confer antidepressant-like effects to naive mice.
    Authors: Brachman R, Lehmann M, Maric D, Herkenham M
    J Neurosci, 2015;35(4):1530-8.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  97. Impaired macrophage autophagy increases the immune response in obese mice by promoting proinflammatory macrophage polarization.
    Authors: Liu K, Zhao E, Ilyas G, Lalazar G, Lin Y, Haseeb M, Tanaka K, Czaja M
    Autophagy, 2015;11(2):271-84.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  98. B Cell-Intrinsic Expression of the HuR RNA-Binding Protein Is Required for the T Cell-Dependent Immune Response In Vivo.
    Authors: DeMicco A, Naradikian M, Sindhava V, Yoon J, Gorospe M, Wertheim G, Cancro M, Bassing C
    J Immunol, 2015;195(7):3449-62.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  99. Immunosuppression in early postnatal days induces persistent and allergen-specific immune tolerance to asthma in adult mice.
    Authors: Chen, Yan, Zhang, Jin, Lu, Yong, Wang, Libo
    PLoS ONE, 2015;10(4):e0122990.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  100. Toll-like receptor ligands sensitize B-cell receptor signalling by reducing actin-dependent spatial confinement of the receptor.
    Authors: Freeman S, Jaumouille V, Choi K, Hsu B, Wong H, Abraham L, Graves M, Coombs D, Roskelley C, Das R, Grinstein S, Gold M
    Nat Commun, 2015;6(0):6168.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  101. Glycogen Synthase Kinase-3beta (GSK-3beta) Inhibition Enhances Dendritic Cell-based Cancer Vaccine Potency via Suppression of Interferon-gamma-induced Indoleamine 2,3-Dioxygenase Expression.
    Authors: Noh K, Son K, Jung I, Kang T, Choi C, Park Y
    J Biol Chem, 2015;290(19):12394-402.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  102. Constraints contributed by chromatin looping limit recombination targeting during Ig class switch recombination.
    Authors: Feldman S, Achour I, Wuerffel R, Kumar S, Gerasimova T, Sen R, Kenter A
    J Immunol, 2015;194(5):2380-9.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  103. DNA-dependent protein kinase inhibition blocks asthma in mice and modulates human endothelial and CD4(+) T-cell function without causing severe combined immunodeficiency.
    Authors: Ghonim M, Pyakurel K, Ju J, Rodriguez P, Lammi M, Davis C, Abughazleh M, Mansy M, Naura A, Boulares A
    J Allergy Clin Immunol, 2015;135(2):425-40.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  104. Cytokine-induced killer cells co-cultured with dendritic cells loaded with the protein lysate produced by radiofrequency ablation induce a specific antitumor response.
    Authors: Shan, Chan-Cha, Shi, Liang-Ro, Ding, Mei-Qian, Zhu, Yi-Bei, Li, Xiao-Don, Xu, Bin, Jiang, Jing-Tin, Wu, Chang-Pi
    Oncol Lett, 2015;9(4):1549-1556.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  105. Concentrated protein body product derived from rice endosperm as an oral tolerogen for allergen-specific immunotherapy--a new mucosal vaccine formulation against Japanese cedar pollen allergy.
    Authors: Wakasa Y, Takagi H, Watanabe N, Kitamura N, Fujiwara Y, Ogo Y, Hayashi S, Yang L, Ohta M, Thet Tin W, Sekikawa K, Takano M, Ozawa K, Hiroi T, Takaiwa F
    PLoS ONE, 2015;10(3):e0120209.
    Species: Mouse
    Sample Type: In Vivo
  106. IRAK-M promotes alternative macrophage activation and fibroproliferation in bleomycin-induced lung injury.
    Authors: Ballinger M, Newstead M, Zeng X, Bhan U, Mo X, Kunkel S, Moore B, Flavell R, Christman J, Standiford T
    J Immunol, 2015;194(4):1894-904.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  107. Redundant function of DNA ligase 1 and 3 in alternative end-joining during immunoglobulin class switch recombination.
    Authors: Masani S, Han L, Meek K, Yu K
    Proc Natl Acad Sci U S A, 2015;113(5):1261-6.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  108. IL-4 induces a suppressive IL-10-producing CD8+ T cell population via a Cdkn2a-dependent mechanism.
    Authors: Zhao Y, Zhao H, Sun Y, Hao J, Qi X, Zhou X, Wu Z, Wang P, Kaech S, Weaver C, Flavell R, Zhao L, Yao Z, Yin Z
    J Leukoc Biol, 2015;94(6):1103-12.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  109. Ligase I and ligase III mediate the DNA double-strand break ligation in alternative end-joining.
    Authors: Lu G, Duan J, Shu S, Wang X, Gao L, Guo J, Zhang Y
    Proc Natl Acad Sci U S A, 2015;113(5):1256-60.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  110. The DNA-binding inhibitor Id3 regulates IL-9 production in CD4(+) T cells.
    Authors: Nakatsukasa H, Zhang D, Maruyama T, Chen H, Cui K, Ishikawa M, Deng L, Zanvit P, Tu E, Jin W, Abbatiello B, Goldberg N, Chen Q, Sun L, Zhao K, Chen W
    Nat Immunol, 2015;16(10):1077-84.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  111. Glucose-dependent de novo lipogenesis in B lymphocytes: a requirement for atp-citrate lyase in lipopolysaccharide-induced differentiation.
    Authors: Dufort, Fay J, Gumina, Maria R, Ta, Nathan L, Tao, Yongzhen, Heyse, Shannon, Scott, David A, Richardson, Adam D, Seyfried, Thomas N, Chiles, Thomas C
    J Biol Chem, 2014;289(10):7011-24.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  112. Macrophage PTEN regulates expression and secretion of arginase I modulating innate and adaptive immune responses.
    Authors: Sahin E, Haubenwallner S, Kuttke M, Kollmann I, Halfmann A, Dohnal A, Chen L, Cheng P, Hoesel B, Einwallner E, Brunner J, Kral J, Schrottmaier W, Thell K, Saferding V, Bluml S, Schabbauer G
    J Immunol, 2014;193(4):1717-27.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  113. Accelerated neurodegeneration and neuroinflammation in transgenic mice expressing P301L tau mutant and tau-tubulin kinase 1.
    Authors: Asai H, Ikezu S, Woodbury M, Yonemoto G, Cui L, Ikezu T
    Am J Pathol, 2014;184(3):808-18.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  114. Aging is associated with increased regulatory T-cell function.
    Authors: Garg S, Delaney C, Toubai T, Ghosh A, Reddy P, Banerjee R, Yung R
    Aging Cell, 2014;13(3):441-8.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  115. MHC class II transactivator is an in vivo regulator of osteoclast differentiation and bone homeostasis co-opted from adaptive immunity.
    Authors: Benasciutti E, Mariani E, Oliva L, Scolari M, Perilli E, Barras E, Milan E, Orfanelli U, Fazzalari N, Campana L, Capobianco A, Otten L, Particelli F, Acha-Orbea H, Baruffaldi F, Faccio R, Sitia R, Reith W, Cenci S
    J Bone Miner Res, 2014;29(2):290-303.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  116. Axl receptor blockade ameliorates pulmonary pathology resulting from primary viral infection and viral exacerbation of asthma.
    Authors: Shibata T, Habiel D, Coelho A, Kunkel S, Lukacs N, Hogaboam C
    J Immunol, 2014;192(8):3569-81.
    Species: Mouse
    Sample Type: Tissue Homogenates
    Application: Luminex standard
  117. Lysosomal stress in obese adipose tissue macrophages contributes to MITF-dependent Gpnmb induction.
    Authors: Gabriel T, Tol M, Ottenhof R, van Roomen C, Aten J, Claessen N, Hooibrink B, de Weijer B, Serlie M, Argmann C, van Elsenburg L, Aerts J, van Eijk M
    Diabetes, 2014;63(10):3310-23.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  118. Enhancement of tumor-specific T cell-mediated immunity in dendritic cell-based vaccines by Mycobacterium tuberculosis heat shock protein X.
    Authors: Jung I, Shin S, Lee M, Kang T, Han H, Lee S, Kim W, Kim H, Park W, Kim H, Yun C, Lee E, Wu T, Park Y
    J Immunol, 2014;193(3):1233-45.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  119. Preferential macrophage recruitment and polarization in LPS-induced animal model for COPD: noninvasive tracking using MRI.
    Authors: Al Faraj, Achraf, Sultana Shaik, Asma, Pureza, Mary Ang, Alnafea, Mohammad, Halwani, Rabih
    PLoS ONE, 2014;9(3):e90829.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  120. TRAF5 negatively regulates TLR signaling in B lymphocytes.
    Authors: Buchta C, Bishop G
    J Immunol, 2014;192(1):145-50.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  121. Kruppel-like transcription factor 6 regulates inflammatory macrophage polarization.
    Authors: Date D, Das R, Narla G, Simon D, Jain M, Mahabeleshwar G
    J Biol Chem, 2014;289(15):10318-29.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  122. Alternative splice variants of AID are not stoichiometrically present at the protein level in chronic lymphocytic leukemia.
    Authors: Rebhandl S, Huemer M, Zaborsky N, Gassner F, Catakovic K, Felder T, Greil R, Geisberger R
    Eur J Immunol, 2014;44(7):2175-87.
    Species: Mouse
    Sample Type: Whole Tissue
    Application: Bioassay
  123. Noncoding RNA transcription targets AID to divergently transcribed loci in B cells.
    Authors: Pefanis, Evangelo, Wang, Jiguang, Rothschild, Gerson, Lim, Junghyun, Chao, Jaime, Rabadan, Raul, Economides, Aris N, Basu, Uttiya
    Nature, 2014;514(7522):389-93.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  124. IL-17A as an inducer for Th2 immune responses in murine atopic dermatitis models.
    Authors: Nakajima S, Kitoh A, Egawa G, Natsuaki Y, Nakamizo S, Moniaga C, Otsuka A, Honda T, Hanakawa S, Amano W, Iwakura Y, Nakae S, Kubo M, Miyachi Y, Kabashima K
    J Invest Dermatol, 2014;134(8):2122-30.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  125. Developmental propagation of V(D)J recombination-associated DNA breaks and translocations in mature B cells via dicentric chromosomes.
    Authors: Hu, Jiazhi, Tepsuporn, Suprawee, Meyers, Robin M, Gostissa, Monica, Alt, Frederic
    Proc Natl Acad Sci U S A, 2014;111(28):10269-74.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  126. Elongated TCR alpha chain CDR3 favors an altered CD4 cytokine profile.
    Authors: Reynolds C, Chong D, Raynsford E, Quigley K, Kelly D, Llewellyn-Hughes J, Altmann D, Boyton R
    BMC Biol, 2014;12(0):32.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  127. Unique macrophages different from M1/M2 macrophages inhibit T cell mitogenesis while upregulating Th17 polarization.
    Authors: Tatano Y, Shimizu T, Tomioka H
    Sci Rep, 2014;4(0):4146.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  128. Improved repair of dermal wounds in mice lacking microRNA-155.
    Authors: van Solingen C, Araldi E, Chamorro-Jorganes A, Fernandez-Hernando C, Suarez Y
    J Cell Mol Med, 2014;18(6):1104-12.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  129. Germinal center B cell maintenance and differentiation are controlled by distinct NF-kappaB transcription factor subunits.
    Authors: Heise N, De Silva N, Silva K, Carette A, Simonetti G, Pasparakis M, Klein U
    J Exp Med, 2014;211(10):2103-18.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  130. Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity.
    Authors: Ramkhelawon B, Hennessy E, Menager M, Ray T, Sheedy F, Hutchison S, Wanschel A, Oldebeken S, Geoffrion M, Spiro W, Miller G, McPherson R, Rayner K, Moore K
    Nat Med, 2014;20(4):377-84.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  131. Characterization of the structure and immunostimulatory activity of a vaccine adjuvant, de-O-acylated lipooligosaccharide.
    Authors: Han, Ji Eun, Wui, Seo Ri, Kim, Kwang Su, Cho, Yang Je, Cho, Wan Je, Lee, Na Gyong
    PLoS ONE, 2014;9(1):e85838.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  132. Acanthamoeba protease activity promotes allergic airway inflammation via protease-activated receptor 2.
    Authors: Park, Mi Kyung, Cho, Min Kyou, Kang, Shin Ae, Park, Hye-Kyun, Kim, Dong-Hee, Yu, Hak Sun
    PLoS ONE, 2014;9(3):e92726.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  133. Functional polarization of tumour-associated macrophages by tumour-derived lactic acid.
    Authors: Colegio O, Chu N, Szabo A, Chu T, Rhebergen A, Jairam V, Cyrus N, Brokowski C, Eisenbarth S, Phillips G, Cline G, Phillips A, Medzhitov R
    Nature, 2014;513(7519):559-63.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  134. S100A8 induces IL-10 and protects against acute lung injury.
    Authors: Hiroshima Y, Hsu K, Tedla N, Chung Y, Chow S, Herbert C, Geczy C
    J Immunol, 2014;192(6):2800-11.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  135. IkappaB kinase activity drives fetal lung macrophage maturation along a non-M1/M2 paradigm.
    Authors: Stouch A, Zaynagetdinov R, Barham W, Stinnett A, Slaughter J, Yull F, Hoffman H, Blackwell T, Prince L
    J Immunol, 2014;193(3):1184-93.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  136. DMXAA causes tumor site-specific vascular disruption in murine non-small cell lung cancer, and like the endogenous non-canonical cyclic dinucleotide STING agonist, 2'3'-cGAMP, induces M2 macrophage repolarization.
    Authors: Downey C, Aghaei M, Schwendener R, Jirik F
    PLoS ONE, 2014;9(6):e99988.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  137. Colony-stimulating factor-1 signaling suppresses renal crystal formation.
    Authors: Taguchi K, Okada A, Kitamura H, Yasui T, Naiki T, Hamamoto S, Ando R, Mizuno K, Kawai N, Tozawa K, Asano K, Tanaka M, Miyoshi I, Kohri K
    J Am Soc Nephrol, 2014;25(8):1680-97.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  138. Binding of AID to DNA does not correlate with mutator activity.
    Authors: Matthews A, Husain S, Chaudhuri J
    J Immunol, 2014;193(1):252-7.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  139. Uracil excision by endogenous SMUG1 glycosylase promotes efficient Ig class switching and impacts on A:T substitutions during somatic mutation.
    Authors: Dingler F, Kemmerich K, Neuberger M, Rada C
    Eur J Immunol, 2014;44(7):1925-35.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  140. Failed renoprotection by alternatively activated bone marrow macrophages is due to a proliferation-dependent phenotype switch in vivo.
    Authors: Cao Q, Wang Y, Zheng D, Sun Y, Wang C, Wang X, Lee V, Wang Y, Zheng G, Tan T, Wang Y, Alexander S, Harris D
    Kidney Int, 2014;85(4):794-806.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  141. Role of Blimp-1 in programing Th effector cells into IL-10 producers.
    Authors: Neumann C, Heinrich F, Neumann K, Junghans V, Mashreghi M, Ahlers J, Janke M, Rudolph C, Mockel-Tenbrinck N, Kuhl A, Heimesaat M, Esser C, Im S, Radbruch A, Rutz S, Scheffold A
    J Exp Med, 2014;211(9):1807-19.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  142. A role for the ITAM signaling module in specifying cytokine-receptor functions.
    Authors: Bezbradica J, Rosenstein R, DeMarco R, Brodsky I, Medzhitov R
    Nat Immunol, 2014;15(4):333-42.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  143. Mouse BAZ1A (ACF1) is dispensable for double-strand break repair but is essential for averting improper gene expression during spermatogenesis.
    Authors: Dowdle J, Mehta M, Kass E, Vuong B, Inagaki A, Egli D, Jasin M, Keeney S
    PLoS Genet, 2013;9(11):e1003945.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  144. TNF-like ligand 1A (TL1A) gene knockout leads to ameliorated collagen-induced arthritis in mice: implication of TL1A in humoral immune responses.
    Authors: Wang X, Hu Y, Charpentier T, Lamarre A, Qi S, Wu J, Luo H
    J Immunol, 2013;191(11):5420-9.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  145. Inflammasome adaptor protein Apoptosis-associated speck-like protein containing CARD (ASC) is critical for the immune response and survival in west Nile virus encephalitis.
    Authors: Kumar M, Roe K, Orillo B, Muruve D, Nerurkar V, Gale M, Verma S
    J Virol, 2013;87(7):3655-67.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  146. Tetraspanin CD37 contributes to the initiation of cellular immunity by promoting dendritic cell migration.
    Authors: Gartlan K, Wee J, Demaria M, Nastovska R, Chang T, Jones E, Apostolopoulos V, Pietersz G, Hickey M, van Spriel A, Wright M
    Eur J Immunol, 2013;43(5):1208-19.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  147. p53 controls autoimmune arthritis via STAT-mediated regulation of the Th17 cell/Treg cell balance in mice.
    Authors: Park J, Lim M, Cho M, Ryu J, Moon Y, Jhun J, Byun J, Kim E, Hwang S, Ju J, Kwok S, Kim H
    Arthritis Rheum, 2013;65(4):949-59.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  148. The exonuclease Trex1 restrains macrophage proinflammatory activation.
    Authors: Pereira-Lopes S, Celhar T, Sans-Fons G, Serra M, Fairhurst A, Lloberas J, Celada A
    J Immunol, 2013;191(12):6128-35.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  149. Antigen-specific induced T regulatory cells impair dendritic cell function via an IL-10/MARCH1-dependent mechanism.
    Authors: Chattopadhyay, Gouri, Shevach, Ethan M
    J Immunol, 2013;191(12):5875-84.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  150. Functional education of invariant NKT cells by dendritic cell tuning of SHP-1.
    Authors: Napolitano, Anna, Pittoni, Paola, Beaudoin, Lucie, Lehuen, Agnes, Voehringer, David, MacDonald, H Robson, Dellabona, Paolo, Casorati, Giulia
    J Immunol, 2013;190(7):3299-308.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  151. Differential requirements of CD4(+) T-cell signals for effector cytotoxic T-lymphocyte (CTL) priming and functional memory CTL development at higher CD8(+) T-cell precursor frequency.
    Authors: Umeshappa C, Nanjundappa R, Xie Y, Freywald A, Xu Q, Xiang J
    Immunology, 2013;138(4):298-306.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  152. Rgs13 constrains early B cell responses and limits germinal center sizes.
    Authors: Hwang I, Hwang K, Park C, Harrison K, Kehrl J
    PLoS ONE, 2013;8(3):e60139.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  153. Bee venom phospholipase A2 induces a primary type 2 response that is dependent on the receptor ST2 and confers protective immunity.
    Authors: Palm N, Rosenstein R, Yu S, Schenten D, Florsheim E, Medzhitov R
    Immunity, 2013;39(5):976-85.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  154. Control of T helper 2 responses by transcription factor IRF4-dependent dendritic cells.
    Authors: Gao Y, Nish S, Jiang R, Hou L, Licona-Limon P, Weinstein J, Zhao H, Medzhitov R
    Immunity, 2013;39(4):722-32.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  155. Apurinic/apyrimidinic endonuclease 1 is the essential nuclease during immunoglobulin class switch recombination.
    Authors: Masani, Shahnaz, Han, Li, Yu, Kefei
    Mol Cell Biol, 2013;33(7):1468-73.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  156. Scaffold functions of 14-3-3 adaptors in B cell immunoglobulin class switch DNA recombination.
    Authors: Lam T, Thomas L, White C, Li G, Pone E, Xu Z, Casali P
    PLoS ONE, 2013;8(11):e80414.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  157. Prostate cancer stem cells are targets of both innate and adaptive immunity and elicit tumor-specific immune responses.
    Authors: Jachetti, Elena, Mazzoleni, Stefania, Grioni, Matteo, Ricupito, Alessia, Brambillasca, Chiara, Generoso, Luca, Calcinotto, Arianna, Freschi, Massimo, Mondino, Anna, Galli, Rossella, Bellone, Matteo
    Oncoimmunology, 2013;2(5):e24520.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  158. Regulation of Foxp3+ inducible regulatory T cell stability by SOCS2.
    Authors: Knosp C, Schiering C, Spence S, Carroll H, Nel H, Osbourn M, Jackson R, Lyubomska O, Malissen B, Ingram R, Fitzgerald D, Powrie F, Fallon P, Johnston J, Kissenpfennig A
    J Immunol, 2013;190(7):3235-45.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  159. The role of Bruton's tyrosine kinase in the development and BCR/TLR-dependent activation of AM14 rheumatoid factor B cells.
    Authors: Nundel K, Busto P, Debatis M, Marshak-Rothstein A
    J Leukoc Biol, 2013;94(5):865-75.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  160. Identification, characterization, and isolation of a common progenitor for osteoclasts, macrophages, and dendritic cells from murine bone marrow and periphery.
    Authors: Jacome-Galarza C, Lee S, Lorenzo J, Aguila H
    J Bone Miner Res, 2013;28(5):1203-13.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  161. IL-4/IL-13-dependent and independent expression of miR-124 and its contribution to M2 phenotype of monocytic cells in normal conditions and during allergic inflammation.
    Authors: Veremeyko, Tatyana, Siddiqui, Shafiudd, Sotnikov, Ilya, Yung, Amanda, Ponomarev, Eugene D
    PLoS ONE, 2013;8(12):e81774.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  162. Mycobacterium tuberculosis RpfB drives Th1-type T cell immunity via a TLR4-dependent activation of dendritic cells.
    Authors: Kim J, Kim W, Choi H, Jang B, Lee K, Park J, Kim H, Cho S, Shin S
    J Leukoc Biol, 2013;94(4):733-49.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  163. Age- and light-dependent development of localised retinal atrophy in CCL2(-/-)CX3CR1(GFP/GFP) mice.
    Authors: Chen M, Hombrebueno J, Luo C, Penalva R, Zhao J, Colhoun L, Pandi S, Forrester J, Xu H
    PLoS ONE, 2013;8(4):e61381.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  164. Dissociation of endotoxin tolerance and differentiation of alternatively activated macrophages.
    Authors: Rajaiah R, Perkins D, Polumuri S, Zhao A, Keegan A, Vogel S
    J Immunol, 2013;190(9):4763-72.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  165. Activated macrophages release microvesicles containing polarized M1 or M2 mRNAs.
    Authors: Garzetti, Livia, Menon, Ramesh, Finardi, Annamari, Bergami, Alessand, Sica, Antonio, Martino, Gianvito, Comi, Giancarl, Verderio, Claudia, Farina, Cinthia, Furlan, Roberto
    J Leukoc Biol, 2013;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  166. 12/15-lipoxygenase expressed in non-epithelial cells causes airway epithelial injury in asthma.
    Authors: Mabalirajan U, Rehman R, Ahmad T, Kumar S, Leishangthem G, Singh S, Dinda A, Biswal S, Agrawal A, Ghosh B
    Sci Rep, 2013;3(0):1540.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  167. Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) and nuclear factor-kappaB (NF-kappaB): a feed-forward loop for systemic and vascular inflammation.
    Authors: Leslie K, Song G, Barrick S, Wehbi V, Vilardaga J, Bauer P, Bisello A
    J Biol Chem, 2013;288(51):36426-36.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  168. The MSHA Strain of Pseudomonas Aeruginosa Activated TLR Pathway and Enhanced HIV-1 DNA Vaccine Immunoreactivity.
    Authors: Hou J, Liu Y, Liu Y, Shao Y
    PLoS ONE, 2012;7(10):e47724.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  169. An epigenetic silencing pathway controlling T helper 2 cell lineage commitment.
    Authors: Allan RS, Zueva E, Cammas F, Schreiber HA, Masson V, Belz GT, Roche D, Maison C, Quivy JP, Almouzni G, Amigorena S
    Nature, 2012;487(7406):249-53.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  170. Dendritic cell exosomes directly kill tumor cells and activate natural killer cells via TNF superfamily ligands.
    Authors: Munich S, Sobo-Vujanovic A, Buchser W, Beer-Stolz D, Vujanovic N
    Oncoimmunology, 2012;1(7):1074-1083.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  171. Breast regression protein-39 (BRP-39) promotes dendritic cell maturation in vitro and enhances Th2 inflammation in murine model of asthma.
    Authors: Xu Q, Chai S, Qian Y, Zhang M, Wang K
    Acta Pharmacol Sin, 2012;33(12):1525-32.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Cell Culture Substrate
  172. Regulation of innate CD8+ T-cell activation mediated by cytokines.
    Proc Natl Acad Sci U S A, 2012;109(25):9971-6.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  173. Protein kinase C delta (PKCdelta)-extracellular signal-regulated kinase 1/2 (ERK1/2) signaling cascade regulates glycogen synthase kinase-3 (GSK-3) inhibition-mediated interleukin-10 (IL-10) expression in lipopolysaccharide (LPS)-induced endotoxemia.
    Authors: Noh KT, Son KH, Jung ID, Kang HK, Hwang SA, Lee WS, You JC, Park YM
    J. Biol. Chem., 2012;287(17):14226-33.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  174. Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells.
    Nat. Med., 2012;1248(0):18.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  175. TNFR-Associated Factor 2 Deficiency in B Lymphocytes Predisposes to Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma in Mice.
    Authors: Perez-Chacon G, Llobet D, Pardo C, Pindado J, Choi Y, Reed JC, Zapata JM
    J. Immunol., 2012;189(2):1053-61.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  176. CCL25 induces alpha 4 beta 7 integrin-dependent migration of IL-17+ gamma/delta T lymphocytes during an allergic reaction.
    Authors: Costa MF, Bornstein VU, Candea AL, Henriques-Pons A, Henriques MG, Penido C
    Eur. J. Immunol., 2012;42(5):1250-60.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  177. The effect of conditional EFNB1 deletion in the T cell compartment on T cell development and function.
    Authors: Jin W, Qi S, Luo H
    BMC Immunol., 2011;12(0):68.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  178. Proinflammatory clearance of apoptotic neutrophils induces an IL-12(low)IL-10(high) regulatory phenotype in macrophages.
    Authors: Filardy AA, Pires DR, Nunes MP, Takiya CM, Freire-de-Lima CG, Ribeiro-Gomes FL, DosReis GA
    J. Immunol., 2010;185(4):2044-50.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  179. A novel role for constitutively expressed epithelial-derived chemokines as antibacterial peptides in the intestinal mucosa.
    Authors: Kotarsky K, Sitnik KM, Stenstad H, Kotarsky H, Schmidtchen A, Koslowski M, Wehkamp J, Agace WW
    Mucosal Immunol, 2010;3(1):40-8.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  180. Oncostatin M induces dendritic cell maturation and Th1 polarization.
    Authors: Jung ID, Noh KT, Lee CM, Chun SH, Jeong SK, Park JW, Park WS, Kim HW, Yun CH, Shin YK, Park YM
    Biochem. Biophys. Res. Commun., 2010;394(2):272-8.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Media Supplement - Cell Prep
  181. The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation.
    Authors: Chang HC, Sehra S, Goswami R, Yao W, Yu Q, Stritesky GL, Jabeen R, McKinley C, Ahyi AN, Han L, Nguyen ET, Robertson MJ, Perumal NB, Tepper RS, Nutt SL, Kaplan MH
    Nat. Immunol., 2010;11(6):527-34.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  182. Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus.
    Authors: Kayamuro H, Yoshioka Y, Abe Y, Arita S, Katayama K, Nomura T, Yoshikawa T, Kubota-Koketsu R, Ikuta K, Okamoto S, Mori Y, Kunisawa J, Kiyono H, Itoh N, Nagano K, Kamada H, Tsutsumi Y, Tsunoda S
    J. Virol., 2010;84(24):12703-12.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  183. PEGylation of interleukin-10 for the mitigation of enhanced pain states.
    Authors: Soderquist RG, Milligan ED, Harrison JA, Chavez RA, Johnson KW, Watkins LR, Mahoney MJ
    J Biomed Mater Res A, 2010;93(3):1169-79.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  184. Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model.
    Authors: Yoshizaki A, Yanaba K, Iwata Y
    J. Immunol., 2010;185(4):2502-15.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  185. Sustained signaling by canonical helper T cell cytokines throughout the reactive lymph node.
    Authors: Perona-Wright G, Mohrs K, Mohrs M
    Nat. Immunol., 2010;11(6):520-6.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  186. TLR4 ligands induce IFN-alpha production by mouse conventional dendritic cells and human monocytes after IFN-beta priming.
    Authors: Richez C, Yasuda K, Watkins AA
    J. Immunol., 2009;182(2):820-8.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  187. ST2 deficient mice display a normal host defense against pulmonary infection with Mycobacterium tuberculosis.
    Authors: Wieland CW, van der Windt GJ, Florquin S, McKenzie AN, van der Poll T
    Microbes Infect., 2009;11(4):524-30.
  188. The adaptor protein CIKS/Act1 is essential for IL-25-mediated allergic airway inflammation.
    Authors: Claudio E, Sonder SU, Saret S, Carvalho G, Ramalingam TR, Wynn TA, Chariot A, Garcia-Perganeda A, Leonardi A, Paun A, Chen A, Ren NY, Wang H, Siebenlist U
    J. Immunol., 2009;182(3):1617-30.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  189. The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells.
    Authors: Dienz O, Eaton SM, Bond JP, Neveu W, Moquin D, Noubade R, Briso EM, Charland C, Leonard WJ, Ciliberto G, Teuscher C, Haynes L, Rincon M
    J. Exp. Med., 2009;206(1):69-78.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  190. A mechanism for the initiation of allergen-induced T helper type 2 responses.
    Authors: Sokol CL, Barton GM, Farr AG, Medzhitov R
    Nat. Immunol., 2008;9(3):310-8.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  191. Interferon-gamma limits Th1 lymphocyte adhesion to inflamed endothelium: a nitric oxide regulatory feedback mechanism.
    Authors: Norman MU, Zbytnuik L, Kubes P
    Eur. J. Immunol., 2008;38(5):1368-80.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  192. Adenosine receptors in regulation of dendritic cell differentiation and function.
    Authors: Novitskiy SV, Ryzhov S, Zaynagetdinov R, Goldstein AE, Huang Y, Tikhomirov OY, Blackburn MR, Biaggioni I, Carbone DP, Feoktistov I, Dikov MM
    Blood, 2008;112(5):1822-31.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  193. CD14 contributes to pulmonary inflammation and mortality during murine tuberculosis.
    Authors: Wieland CW, van der Windt GJ, Wiersinga WJ, Florquin S, van der Poll T
    Immunology, 2008;125(2):272-9.
    Species: N/A
    Sample Type: N/A
    Application: ELISA Standard
  194. TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice.
    Authors: McKinley L, Alcorn JF, Peterson A, Dupont RB, Kapadia S, Logar A, Henry A, Irvin CG, Piganelli JD, Ray A, Kolls JK
    J. Immunol., 2008;181(6):4089-97.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  195. Direct B cell stimulation by dendritic cells in a mouse model of lupus.
    Authors: Wan S, Zhou Z, Duan B, Morel L
    Arthritis Rheum., 2008;8(0):1741-50.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  196. Controlled delivery of T-box21 small interfering RNA ameliorates autoimmune alopecia (Alopecia Areata) in a C3H/HeJ mouse model.
    Authors: Nakamura M, Jo J, Tabata Y, Ishikawa O
    Am. J. Pathol., 2008;172(3):650-8.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  197. Cytopiloyne, a novel polyacetylenic glucoside from Bidens pilosa, functions as a T helper cell modulator.
    Authors: Chiang YM, Chang CL, Chang SL, Yang WC, Shyur LF
    J Ethnopharmacol, 2007;110(3):532-8.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  198. The IL-4/IL-13/Stat6 signalling pathway promotes luminal mammary epithelial cell development.
    Authors: Khaled WT, Read EK, Nicholson SE, Baxter FO, Brennan AJ, Came PJ, Sprigg N, McKenzie AN, Watson CJ
    Development, 2007;134(15):2739-50.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  199. IL-2 is essential for TGF-beta to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells.
    Authors: Zheng SG, Wang J, Wang P, Gray JD, Horwitz DA
    J. Immunol., 2007;178(4):2018-27.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  200. The JAK-3 inhibitor CP-690550 is a potent anti-inflammatory agent in a murine model of pulmonary eosinophilia.
    Authors: Kudlacz E, Conklyn M, Andresen C, Whitney-Pickett C, Changelian P
    Eur. J. Pharmacol., 2007;582(1):154-61.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  201. Nod1-mediated innate immune recognition of peptidoglycan contributes to the onset of adaptive immunity.
    Authors: Fritz JH, Le Bourhis L, Sellge G, Magalhaes JG, Fsihi H, Kufer TA, Collins C, Viala J, Ferrero RL, Girardin SE, Philpott DJ
    Immunity, 2007;26(4):445-59.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  202. The endothelial cell-produced antiangiogenic cytokine vascular endothelial growth inhibitor induces dendritic cell maturation.
    Authors: Tian F, Grimaldo S, Fujita M, Fugita M, Cutts J, Vujanovic NL, Li LY
    J. Immunol., 2007;179(6):3742-51.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  203. T-bet inhibits both TH2 cell-mediated eosinophil recruitment and TH17 cell-mediated neutrophil recruitment into the airways.
    Authors: Fujiwara M, Hirose K, Kagami S, Takatori H, Wakashin H, Tamachi T, Watanabe N, Saito Y, Iwamoto I, Nakajima H
    J. Allergy Clin. Immunol., 2007;119(3):662-70.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  204. Critical role of the Fc receptor gamma-chain on APCs in the development of allergen-induced airway hyperresponsiveness and inflammation.
    Authors: Kitamura K, Takeda K, Koya T, Miyahara N, Kodama T, Dakhama A, Takai T, Hirano A, Tanimoto M, Harada M, Gelfand EW
    J. Immunol., 2007;178(1):480-8.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  205. IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance.
    Authors: Zelante T, De Luca A, Bonifazi P, Montagnoli C, Bozza S, Moretti S, Belladonna ML, Vacca C, Conte C, Mosci P, Bistoni F, Puccetti P, Kastelein RA, Kopf M, Romani L
    Eur. J. Immunol., 2007;37(10):2695-706.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  206. Dendritic cells loaded with apoptotic antibody-coated tumor cells provide protective immunity against B-cell lymphoma in vivo.
    Authors: Franki SN, Steward KK, Betting DJ, Kafi K, Yamada RE, Timmerman JM
    Blood, 2007;111(3):1504-11.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  207. Interleukin-4 does not influence development of hypercholesterolemia or angiotensin II-induced atherosclerotic lesions in mice.
    Authors: King VL, Cassis LA, Daugherty A
    Am. J. Pathol., 2007;171(6):2040-7.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  208. Liposomal retinoic acids modulate asthma manifestations in mice.
    Authors: Maret M, Ruffie C, Periquet B, Campo AM, Menevret M, Phelep A, Dziewiszek K, Druilhe A, Pretolani M
    J. Nutr., 2007;137(12):2730-6.
    Species: N/A
    Sample Type: N/A
    Application: ELISA Standard
  209. Lentiviral vector-mediated autonomous differentiation of mouse bone marrow cells into immunologically potent dendritic cell vaccines.
    Authors: Koya RC, Kimura T, Ribas A, Rozengurt N, Lawson GW, Faure-Kumar E, Wang HJ, Herschman H, Kasahara N, Stripecke R
    Mol. Ther., 2007;15(5):971-80.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  210. The 130-kDa glycoform of CD43 functions as an E-selectin ligand for activated Th1 cells in vitro and in delayed-type hypersensitivity reactions in vivo.
    Authors: Alcaide P, King SL, Dimitroff CJ, Lim YC, Fuhlbrigge RC, Luscinskas FW
    J. Invest. Dermatol., 2007;127(8):1964-72.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  211. In vivo blockade of OX40 ligand inhibits thymic stromal lymphopoietin driven atopic inflammation.
    Authors: Seshasayee D, Lee WP, Zhou M, Shu J, Suto E, Zhang J, Diehl L, Austin CD, Meng YG, Tan M, Bullens SL, Seeber S, Fuentes ME, Labrijn AF, Graus YM, Miller LA, Schelegle ES, Hyde DM, Wu LC, Hymowitz SG, Martin F
    J. Clin. Invest., 2007;117(12):3868-3878.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  212. Induction and blockage of oligodendrogenesis by differently activated microglia in an animal model of multiple sclerosis.
    Authors: Butovsky O, Landa G, Kunis G, Ziv Y, Avidan H, Greenberg N, Schwartz A, Smirnov I, Pollack A, Jung S, Schwartz M
    J. Clin. Invest., 2006;116(4):905-15.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  213. 3BP2 deficiency impairs the response of B cells, but not T cells, to antigen receptor ligation.
    Authors: de la Fuente MA, Kumar L, Lu B, Geha RS
    Mol. Cell. Biol., 2006;26(14):5214-25.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  214. Cytokine milieu of atopic dermatitis skin subverts the innate immune response to vaccinia virus.
    Authors: Howell MD, Gallo RL, Boguniewicz M, Jones JF, Wong C, Streib JE, Leung DY
    Immunity, 2006;24(3):341-8.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  215. Microglia activated by IL-4 or IFN-gamma differentially induce neurogenesis and oligodendrogenesis from adult stem/progenitor cells.
    Authors: Butovsky O, Ziv Y, Schwartz A, Landa G, Talpalar AE, Pluchino S, Martino G, Schwartz M
    Mol. Cell. Neurosci., 2006;31(1):149-60.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  216. Activin A functions as a Th2 cytokine in the promotion of the alternative activation of macrophages.
    Authors: Ogawa K, Funaba M, Chen Y, Tsujimoto M
    J. Immunol., 2006;177(10):6787-94.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  217. Immunosuppressant triptolide inhibits dendritic cell-mediated chemoattraction of neutrophils and T cells through inhibiting Stat3 phosphorylation and NF-kappaB activation.
    Authors: Liu Q, Chen T, Chen G, Li N, Wang J, Ma P, Cao X
    Biochem. Biophys. Res. Commun., 2006;345(3):1122-30.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  218. Severe sepsis exacerbates cell-mediated immunity in the lung due to an altered dendritic cell cytokine profile.
    Authors: Wen H, Hogaboam CM, Gauldie J, Kunkel SL
    Am. J. Pathol., 2006;168(6):1940-50.
    Species: N/A
    Sample Type: N/A
    Application: ELISA Standard
  219. Differential roles of vascular endothelial growth factor receptors 1 and 2 in dendritic cell differentiation.
    Authors: Dikov MM, Ohm JE, Ray N, Tchekneva EE, Burlison J, Moghanaki D, Nadaf S, Carbone DP
    J. Immunol., 2005;174(1):215-22.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  220. Vaccination of apoptotic Fas ligand-expressing tumors decreased antitumor responses by enhanced production of immunosuppressive cytokines.
    Authors: Wada A, Tada Y, Shimozato O, Takiguchi Y, Tatsumi K, Kuriyama T, Tagawa M
    Anticancer Res., 2005;25(1):299-303.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  221. IL-1 mediates TNF-induced osteoclastogenesis.
    Authors: Wei S, Kitaura H, Zhou P, Ross FP, Teitelbaum SL
    J. Clin. Invest., 2005;115(2):282-90.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  222. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages.
    Authors: Harrington, Laurie E, Hatton, Robin D, Mangan, Paul R, Turner, Henriett, Murphy, Theresa, Murphy, Kenneth, Weaver, Casey T
    Nat Immunol, 2005;6(11):1123-32.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  223. NK cell activation by dendritic cells (DCs) requires the formation of a synapse leading to IL-12 polarization in DCs.
    Authors: Borg C, Jalil A, Laderach D, Maruyama K, Wakasugi H, Charrier S, Ryffel B, Cambi A, Figdor C, Vainchenker W, Galy A, Caignard A, Zitvogel L
    Blood, 2004;104(10):3267-75.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  224. Increased and long-term generation of dendritic cells with reduced function from IL-6-deficient bone marrow.
    Authors: Bleier JI, Pillarisetty VG, Shah AB, DeMatteo RP
    J. Immunol., 2004;172(12):7408-16.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  225. Control of Leishmania major in the absence of Tyk2 kinase.
    Authors: Schleicher U, Mattner J, Blos M, Schindler H, Rollinghoff M, Karaghiosoff M, Muller M, Werner-Felmayer G, Bogdan C
    Eur. J. Immunol., 2004;34(2):519-29.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  226. P-selectin mediates IL-13-induced eosinophil transmigration but not eotaxin generation in vivo: a comparative study with IL-4-elicited responses.
    Authors: Larbi KY, Dangerfield JP, Culley FJ, Marshall D, Haskard DO, Jose PJ, Williams TJ, Nourshargh S
    J. Leukoc. Biol., 2003;73(1):65-73.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  227. Dual roles of IL-4 in lung injury and fibrosis.
    Authors: Huaux F, Liu T, McGarry B, Ullenbruch M, Phan SH
    J. Immunol., 2003;170(4):2083-92.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  228. Intracellular thiols contribute to Th2 function via a positive role in IL-4 production.
    Authors: Monick MM, Samavati L, Butler NS, Mohning M, Powers LS, Yarovinsky T, Spitz DR, Hunninghake GW
    J. Immunol., 2003;171(10):5107-15.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  229. AMD3100, a CxCR4 antagonist, attenuates allergic lung inflammation and airway hyperreactivity.
    Authors: Lukacs NW, Berlin A, Schols D, Skerlj RT, Bridger GJ
    Am. J. Pathol., 2002;160(4):1353-60.
    Species: N/A
    Sample Type: N/A
    Application: ELISA Standard
  230. The IL-6 family cytokines, interleukin-6, interleukin-11, oncostatin M, and leukemia inhibitory factor, enhance mast cell growth through fibroblast-dependent pathway in mice.
    Authors: Gyotoku E, Morita E, Kameyoshi Y, Hiragun T, Yamamoto S, Hide M
    Arch. Dermatol. Res., 2001;293(10):508-14.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  231. Cytokine production by mouse myeloid dendritic cells in relation to differentiation and terminal maturation induced by lipopolysaccharide or CD40 ligation.
    Authors: Morelli AE, Zahorchak AF, Larregina AT
    Blood, 2001;98(5):1512-23.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  232. Antibodies to vascular endothelial growth factor enhance the efficacy of cancer immunotherapy by improving endogenous dendritic cell function.
    Authors: Gabrilovich DI, 2018, Ishida T, Nadaf S, Ohm JE, Carbone DP
    1537, 1999;5(10):2963-70.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  233. Human macrophages induce CD4(+)Foxp3(+) regulatory T cells via binding and re-release of TGF-beta.
    Authors: Schmidt A, Zhang X, Joshi R, Iqbal S, Wahlund C, Gabrielsson S, Harris R, Tegner J
    Immunol Cell Biol, 0;94(8):747-62.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
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Average Rating: 4.6 (Based on 5 reviews)

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We have 5 reviews tested in 3 applications: Cell proliferation, In vitro bioactivity in cell culture, Binding assay/Protein-protein interaction.

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Very Good
 Cell proliferation Anonymous 07/13/2018
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Application Cell proliferation
Excellent
 In vitro bioactivity in cell culture Anonymous 04/02/2018
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Application In vitro bioactivity in cell culture
Binding assay/Protein-protein interaction Recombinant Mouse IL-4 Protein 404-ML Array 404-ML
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 Binding assay/Protein-protein interaction Anonymous 02/07/2018
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Binding assay/Protein-protein interaction Recombinant Mouse IL-4 Protein 404-ML
Binding assay/Protein-protein interaction: Recombinant Mouse IL-4 Protein [404-ML].

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Application Binding assay/Protein-protein interaction
Reason for Rating MAB404 binds rhuIL-13Ra2
In vitro bioactivity in cell culture Recombinant Mouse IL-4 Protein 404-ML Array 404-ML
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Excellent
 In vitro bioactivity in cell culture Anonymous 07/21/2016
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In vitro bioactivity in cell culture Recombinant Mouse IL-4 Protein 404-ML
In vitro bioactivity in cell culture: Recombinant Mouse IL-4 Protein [404-ML].

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Application In vitro bioactivity in cell culture

Other Experimental Details

Other Experimental Details We used recombinant mouse IL-4 to polarize bonemarrow-derived macrophages to an "M2" phenotype in vitro. We first generated macrophages from whole bone marrow using MCSF-rich media for 7 days. Then we added IL-4 at 20 ng/ml for 48 hours. Using IL-4R wild-type or knock-out bone marrow, we demonstrated using flow cytometry for an M2 reporter (Arginase1-YFP) that the IL-4 acts through the IL-4 receptor to polarize bone marrow derived macrophages towards the M2 phenotype.
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 In vitro bioactivity in cell culture Anonymous 01/21/2016
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In vitro bioactivity in cell culture Recombinant Mouse IL-4 Protein 404-ML
In vitro bioactivity in cell culture: Recombinant Mouse IL-4 Protein [404-ML].

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Application In vitro bioactivity in cell culture

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