Recombinant Mouse Noggin Protein

Newer Version Available: 6997-NG/CF
NEW
A New rm Noggin is Now Available! ~2 fold better activity; Lower endotoxin specification; Enhanced purity; No tag!

Carrier Free

Catalog # Availability Size / Price Qty
1967-NG-025/CF
1967-NG-100/CF

With Carrier

Catalog # Availability Size / Price Qty
1967-NG-025
Graph showing dose-dependent bioactivity of mouse Noggin protein
1 Image
Product Details
Citations (80)
FAQs
Reviews (3)

Recombinant Mouse Noggin Protein Summary

Product Specifications

Purity
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Level
<0.10 EU per 1 μg of the protein by the LAL method.
Activity
Measured by its ability to inhibit BMP-4-induced alkaline phosphatase production by ATDC5 mouse chondrogenic cells. The ED50 for this effect is 0.06-0.3 µg/mL in the presence of 50 ng/mL of Recombinant Human BMP-4 (Catalog # 314-BP).
Source
Mouse myeloma cell line, NS0-derived mouse Noggin protein
Mouse Noggin
(Leu20-Cys232)
Accession # P97466
IEGRGGGSGGGSGGGS 10-His tag
N-terminus C-terminus
Accession #
N-terminal Sequence
Analysis
Leu20
Structure / Form
Disulfide-linked homodimer
Predicted Molecular Mass
26 kDa (monomer)
SDS-PAGE
30-35 kDa, reducing conditions

Product Datasheets

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1967-NG (with carrier)

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1967-NG/CF (carrier free)

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

1967-NG

Formulation Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

1967-NG/CF

Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Data Image

Bioactivity Bioactivity of Mouse Noggin View Larger

Recombinant mouse Noggin (1967-NG) inhibits recombinant human BMP-4-induced alkaline phosphatase production in the ATDC5 mouse chondrogenic cell line. The ED50 for this effect is 0.06-0.3 µg/mL in the presence of 50 ng/mL of recombinant human BMP-4 (314-BP).

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: Noggin

Noggin was originally cloned based on its dorsalizing activity in Xenopus embryos. Mammalian Noggins were subsequently identified and cloned from human, mouse and rat cDNA libraries. Mouse Noggin cDNA encodes a 232 amino acid (aa) residue precursor protein with 19 aa residue putative signal peptide that is cleaved to generate the 213 aa residue mature protein which is secreted as a homodimeric glycoprotein. Noggin is a highly conserved molecule. Mature mouse Noggin shares 99% and 83% aa sequence identity with human and Xenopus Noggin, respectively. Noggin has a complex pattern of expression during embryogenesis. In the adult, Noggin is expressed in the central nervous system and in several adult peripheral tissues such as lung, skeletal muscle and skin. Noggin has been shown to be a high-affinity BMP (bone morphogenetic protein) binding protein that antagonizes BMP bioactivities.

References
  1. Smith, W.C. and R.M. Harland (1992) Cell 70:829.
  2. Valenzuela, D.M. et al. (1995) J. Neurosci. 15:6077.
  3. Brunet, L.J. et al. (1998) Science 280:1455.
Entrez Gene IDs
9241 (Human); 18121 (Mouse)
Alternate Names
NOG; Noggin; SYM1; symphalangism 1 (proximal); synostoses (multiple) syndrome 1; SYNS1; SYNS1A

Citations for Recombinant Mouse Noggin Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

80 Citations: Showing 1 - 10
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  1. GSK3beta inhibitor-induced dental mesenchymal stem cells regulate ameloblast differentiation
    Authors: A Yamada, K Yoshizaki, K Saito, M Ishikawa, Y Chiba, S Hoshikawa, M Chiba, R Hino, Y Maruya, H Sato, K Masuda, H Yamaza, T Nakamura, T Iwamoto, S Fukumoto
    Journal of oral biosciences, 2022;0(0):.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  2. Aberrant astrocyte protein secretion contributes to altered neuronal development in multiple models of neurodevelopmental disorders
    Authors: ALM Caldwell, L Sancho, J Deng, A Bosworth, A Miglietta, JK Diedrich, MN Shokhirev, NJ Allen
    Nature Neuroscience, 2022;25(9):1163-1178.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  3. Transplantation of intestinal organoids into a mouse model of colitis
    Authors: S Watanabe, S Kobayashi, N Ogasawara, R Okamoto, T Nakamura, M Watanabe, KB Jensen, S Yui
    Nature Protocols, 2022;0(0):.
    Species: Mouse
    Sample Types: Organoid
    Applications: Bioassay
  4. A High-Fat Diet Activates the BAs-FXR Axis and Triggers Cancer-Associated Fibroblast Properties in the Colon
    Authors: TY Kim, S Kim, Y Kim, YS Lee, S Lee, SH Lee, MN Kweon
    Cellular and Molecular Gastroenterology and Hepatology, 2021;0(0):.
    Species: Mouse
    Sample Types: Organoid
    Applications: Bioassay
  5. Intraepithelial lymphocytes suppress the intestinal tumor growth by cell-to-cell contact via CD103/E-cadherin signal
    Authors: R Morikawa, Y Nemoto, Y Yonemoto, S Tanaka, Y Takei, S Oshima, T Nagaishi, K Tsuchiya, K Nozaki, T Mizutani, T Nakamura, M Watanabe, R Okamoto
    Cellular and Molecular Gastroenterology and Hepatology, 2021;0(0):.
    Species: Mouse
    Sample Types: Organoid
    Applications: Bioassay
  6. An in vitro stem cell model of human epiblast and yolk sac interaction
    Authors: KM Mackinlay, BA Weatherbee, V Souza Rosa, CE Handford, G Hudson, T Coorens, LV Pereira, S Behjati, L Vallier, MN Shahbazi, M Zernicka-G
    Elife, 2021;10(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  7. Novel In Vivo Mouse Cryoablation Model to Explore Unique Therapeutic Approaches for Premalignant Columnar Lesions
    Authors: ACP Correia, D Straub, S Calpe, KK Krishnadat
    Methods and protocols, 2021;4(1):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Bioassay
  8. Propionate Enhances Cell Speed and Persistence to Promote Intestinal Epithelial Turnover and Repair
    Authors: AJ Bilotta, C Ma, W Yang, Y Yu, Y Yu, X Zhao, Z Zhou, S Yao, SM Dann, Y Cong
    Cell Mol Gastroenterol Hepatol, 2020;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  9. Novel strategies for expansion of tooth epithelial stem cells and ameloblast generation
    Authors: M Binder, LC Biggs, MS Kronenberg, P Schneider, I Thesleff, A Balic
    Sci Rep, 2020;10(1):4963.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  10. Noggin Inhibits IL-1&beta and BMP-2 Expression, and Attenuates Cartilage Degeneration and Subchondral Bone Destruction in Experimental Osteoarthritis
    Authors: SY Chien, CH Tsai, SC Liu, CC Huang, TH Lin, YZ Yang, CH Tang
    Cells, 2020;9(4):.
    Species: Mouse
    Sample Types:
    Applications: In Vivo
  11. Histone H3 K4/9/27 Trimethylation Levels Affect Wound Healing and Stem Cell Dynamics in Adult Skin
    Authors: S Kang, K Long, S Wang, A Sada, T Tumbar
    Stem Cell Reports, 2019;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  12. The atypical antipsychotic quetiapine induces hyperlipidemia by activating intestinal PXR signaling
    Authors: Z Meng, T Gwag, Y Sui, SH Park, X Zhou, C Zhou
    JCI Insight, 2019;4(3):.
    Species: Mouse
    Sample Types: Enteroid
    Applications: Bioassay
  13. BMP9 stimulates joint regeneration at digit amputation wounds in mice
    Authors: L Yu, LA Dawson, M Yan, K Zimmel, YL Lin, CP Dolan, M Han, K Muneoka
    Nat Commun, 2019;10(1):424.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  14. Loss of PKM2 in Lgr5+ intestinal stem cells promotes colitis-associated colorectal cancer
    Authors: Y Kim, YS Lee, SW Kang, S Kim, TY Kim, SH Lee, SW Hwang, J Kim, EN Kim, JS Ju, YY Park, MN Kweon
    Sci Rep, 2019;9(1):6212.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  15. Identification and Massively Parallel Characterization of Regulatory Elements Driving Neural Induction
    Authors: F Inoue, A Kreimer, T Ashuach, N Ahituv, N Yosef
    Cell Stem Cell, 2019;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  16. Comparative transcriptome analysis of hESC- and iPSC-derived lentoid bodies
    Authors: M Ali, F Kabir, JJ Thomson, Y Ma, C Qiu, M Delannoy, SY Khan, SA Riazuddin
    Sci Rep, 2019;9(1):18552.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  17. HBO Promotes the Differentiation of Neural Stem Cells via Interactions Between the Wnt3/beta-Catenin and BMP2 Signaling Pathways
    Authors: C Chen, Y Yang, Y Yao
    Cell Transplant, 2019;0(0):9636897198835.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Cell Culture
  18. A cancer rainbow mouse for visualizing the functional genomics of oncogenic clonal expansion
    Authors: PG Boone, LK Rochelle, JD Ginzel, V Lubkov, WL Roberts, PJ Nicholls, C Bock, ML Flowers, RJ von Furste, BR Stripp, P Agarwal, AD Borowsky, RD Cardiff, LS Barak, MG Caron, HK Lyerly, JC Snyder
    Nat Commun, 2019;10(1):5490.
    Species: Mouse
    Sample Types: Organoids
    Applications: Cell Culture
  19. NF-kappaB2 signalling in enteroids modulates enterocyte responses to secreted factors from bone marrow-derived dendritic cells
    Authors: LG Jones, A Vaida, LM Thompson, FI Ikuomola, JH Caamaño, MD Burkitt, F Miyajima, JM Williams, BJ Campbell, DM Pritchard, CA Duckworth
    Cell Death Dis, 2019;10(12):896.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Tissue Culture
  20. Establishment of a high-resolution 3D modeling system for studying pancreatic epithelial cell biology in�vitro
    Authors: M Bakhti, K Scheibner, S Tritschler, A Bastidas-P, M Tarquis-Me, FJ Theis, H Lickert
    Mol Metab, 2019;30(0):16-29.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  21. Reovirus-Induced Apoptosis in the Intestine Limits Establishment of Enteric Infection
    Authors: JJ Brown, SP Short, J Stencel-Ba, K Urbanek, AJ Pruijssers, N McAllister, M Ikizler, G Taylor, P Aravamudha, S Khomandiak, B Jabri, CS Williams, TS Dermody
    J. Virol., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  22. Ucma/GRP inhibits phosphate-induced vascular smooth muscle cell calcification via SMAD-dependent BMP signalling
    Authors: BA Willems, M Furmanik, MMJ Caron, MLL Chatrou, DHM Kusters, TJM Welting, M Stock, MS Rafael, CSB Viegas, DC Simes, C Vermeer, CPM Reutelings, LJ Schurgers
    Sci Rep, 2018;8(1):4961.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  23. A single cell transcriptional portrait of embryoid body differentiation and comparison to progenitors of the developing embryo
    Authors: A Spangler, EY Su, AM Craft, P Cahan
    Stem Cell Res, 2018;31(0):201-215.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  24. BVES is required for maintenance of colonic epithelial integrity in experimental colitis by modifying intestinal permeability
    Authors: YA Choksi, VK Reddy, K Singh, CW Barrett, SP Short, B Parang, CE Keating, JJ Thompson, TG Verriere, RE Brown, MB Piazuelo, DM Bader, MK Washington, MK Mittal, T Brand, AP Gobert, LA Coburn, KT Wilson, CS Williams
    Mucosal Immunol, 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  25. Characterization of the enhancer and promoter landscape of inflammatory bowel disease from human colon biopsies
    Authors: M Boyd, M Thodberg, M Vitezic, J Bornholdt, K Vitting-Se, Y Chen, M Coskun, Y Li, BZS Lo, P Klausen, P Jan Schwei, AG Pedersen, N Rapin, K Skovgaard, K Dahlgaard, R Andersson, TB Terkelsen, B Lilje, JT Troelsen, AM Petersen, KB Jensen, I Gögenur, P Thielsen, JB Seidelin, OH Nielsen, JT Bjerrum, A Sandelin
    Nat Commun, 2018;9(1):1661.
    Species: Human
    Sample Types: Organoids
    Applications: Bioassay
  26. Rapid functional genetics of the oligodendrocyte lineage using pluripotent stem cells
    Authors: AM Lager, OG Corradin, JM Cregg, MS Elitt, HE Shick, BLL Clayton, KC Allan, HE Olsen, M Madhavan, PJ Tesar
    Nat Commun, 2018;9(1):3708.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  27. Neutrophils Promote Amphiregulin Production in Intestinal Epithelial Cells through TGF-? and Contribute to Intestinal Homeostasis
    Authors: F Chen, W Yang, X Huang, AT Cao, AJ Bilotta, Y Xiao, M Sun, L Chen, C Ma, X Liu, CG Liu, S Yao, SM Dann, Z Liu, Y Cong
    J. Immunol., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  28. The Coordinated Activities of nAChR and Wnt Signaling Regulate Intestinal Stem Cell Function in Mice
    Authors: T Takahashi, A Shiraishi, J Murata
    Int J Mol Sci, 2018;19(3):.
    Species: Mouse
    Sample Types: Complex Sample Type
    Applications: Bioassay
  29. Reconstituting development of pancreatic intraepithelial neoplasia from primary human pancreas duct cells
    Authors: J Lee, ER Snyder, Y Liu, X Gu, J Wang, BM Flowers, YJ Kim, S Park, GL Szot, RH Hruban, TA Longacre, SK Kim
    Nat Commun, 2017;8(0):14686.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  30. Id2 controls specification of Lgr5+ intestinal stem cell progenitors during gut development
    Authors: L Nigmatulli, M Norkin, MM Dzama, B Messner, S Sayols, N Soshnikova
    EMBO J., 2017;36(7):869-885.
    Species: Mouse
    Sample Types: Organoid
    Applications: Bioassay
  31. Species-specific developmental timing is maintained by pluripotent stem cells ex utero
    Authors: C Barry, MT Schmitz, P Jiang, MP Schwartz, BM Duffin, S Swanson, R Bacher, JM Bolin, AL Elwell, BE McIntosh, R Stewart, JA Thomson
    Dev. Biol., 2017;423(2):101-110.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Differentiation
  32. Hallmarks of Alzheimer's Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain
    Authors: I Espuny-Cam, AM Arranz, M Fiers, A Snellinx, K Ando, S Munck, J Bonnefont, L Lambot, N Corthout, L Omodho, E Vanden Eyn, E Radaelli, I Tesseur, S Wray, A Ebneth, J Hardy, K Leroy, JP Brion, P Vanderhaeg, B De Stroope
    Neuron, 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  33. A Novel Role for the BMP Antagonist Noggin in Sensitizing Cells to Non-canonical Wnt-5a/Ror2/Disheveled Pathway Activation
    Authors: O Bernatik, T Radaszkiew, M Behal, Z Dave, F Witte, A Mahl, NH Cernohorsk, P Krejci, S Stricker, V Bryja
    Front Cell Dev Biol, 2017;5(0):47.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  34. Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells via Temporal Regulation of Wnt Signaling
    Authors: KB McCauley, F Hawkins, M Serra, DC Thomas, A Jacob, DN Kotton
    Cell Stem Cell, 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  35. Adult Mouse Liver Contains Two Distinct Populations of Cholangiocytes
    Authors: B Li, C Dorrell, PS Canaday, C Pelz, A Haft, M Finegold, M Grompe
    Stem Cell Reports, 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  36. Transplantation of Human Embryonic Stem Cell-Derived Retinal Cells into the Subretinal Space of a Non-Human Primate
    Authors: JR Chao, DA Lamba, TR Klesert, A Torre, A Hoshino, RJ Taylor, A Jayabalu, AL Engel, TH Khuu, RK Wang, M Neitz, J Neitz, TA Reh
    Transl Vis Sci Technol, 2017;6(3):4.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  37. A robust vitronectin-derived peptide for the scalable long-term expansion and neuronal differentiation of human pluripotent stem cell (hPSC)-derived neural progenitor cells (hNPCs)
    Authors: Divya Varun
    Acta Biomater, 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  38. Signalling couples hair follicle stem cell quiescence with reduced histone H3 K4/K9/K27me3 for proper tissue homeostasis
    Authors: J Lee, S Kang, KC Lilja, KJ Colletier, CJ Scheitz, YV Zhang, T Tumbar
    Nat Commun, 2016;7(0):11278.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  39. Electrical stimulation drives chondrogenesis of mesenchymal stem cells in the absence of exogenous growth factors
    Sci Rep, 2016;6(0):39302.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  40. Indispensable role of Notch ligand-dependent signaling in the proliferation and stem cell niche maintenance of APC-deficient intestinal tumors
    Authors: Toru Nakata
    Biochem. Biophys. Res. Commun, 2016;0(0):.
    Applications: Bioassay
  41. Selenoprotein P influences colitis-induced tumorigenesis by mediating stemness and oxidative damage.
    Authors: Barrett C, Reddy V, Short S, Motley A, Lintel M, Bradley A, Freeman T, Vallance J, Ning W, Parang B, Poindexter S, Fingleton B, Chen X, Washington M, Wilson K, Shroyer N, Hill K, Burk R, Williams C
    J Clin Invest, 2015;125(7):2646-60.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  42. Acellular lung scaffolds direct differentiation of endoderm to functional airway epithelial cells: requirement of matrix-bound HS proteoglycans.
    Authors: Shojaie S, Ermini L, Ackerley C, Wang J, Chin S, Yeganeh B, Bilodeau M, Sambi M, Rogers I, Rossant J, Bear C, Post M
    Stem Cell Reports, 2015;4(3):419-30.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  43. The formation of proximal and distal definitive endoderm populations in culture requires p38 MAPK activity.
    Authors: Yap C, Goh H, Familari M, Rathjen P, Rathjen J
    J Cell Sci, 2014;127(0):2204-16.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  44. Cooperativity of E-cadherin and Smad4 loss to promote diffuse-type gastric adenocarcinoma and metastasis.
    Authors: Park J, Jang S, Park D, Lim N, Deng C, Kim D, Green J, Kim H
    Mol Cancer Res, 2014;12(8):1088-99.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  45. Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome.
    Authors: Takemura N, Kawasaki T, Kunisawa J, Sato S, Lamichhane A, Kobiyama K, Aoshi T, Ito J, Mizuguchi K, Karuppuchamy T, Matsunaga K, Miyatake S, Mori N, Tsujimura T, Satoh T, Kumagai Y, Kawai T, Standley D, Ishii K, Kiyono H, Akira S, Uematsu S
    Nat Commun, 2014;5(0):3492.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  46. The ErbB4 ligand neuregulin-4 protects against experimental necrotizing enterocolitis.
    Authors: McElroy S, Castle S, Bernard J, Almohazey D, Hunter C, Bell B, Al Alam D, Wang L, Ford H, Frey M
    Am J Pathol, 2014;184(10):2768-78.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  47. Generation of organized germ layers from a single mouse embryonic stem cell.
    Authors: Poh Y, Chen J, Hong Y, Yi H, Zhang S, Chen J, Wu D, Wang L, Jia Q, Singh R, Yao W, Tan Y, Tajik A, Tanaka T, Wang N
    Nat Commun, 2014;5(0):4000.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  48. Small intestinal stem cell identity is maintained with functional Paneth cells in heterotopically grafted epithelium onto the colon.
    Authors: Fukuda M, Mizutani T, Mochizuki W, Matsumoto T, Nozaki K, Sakamaki Y, Ichinose S, Okada Y, Tanaka T, Watanabe M, Nakamura T
    Genes Dev, 2014;28(16):1752-7.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  49. Proinflammatory cytokine-induced tight junction remodeling through dynamic self-assembly of claudins.
    Authors: Capaldo C, Farkas A, Hilgarth R, Krug S, Wolf M, Benedik J, Fromm M, Koval M, Parkos C, Nusrat A
    Mol Biol Cell, 2014;25(18):2710-9.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  50. Bone morphogenetic protein signaling suppresses wound-induced skin repair by inhibiting keratinocyte proliferation and migration.
    Authors: Lewis, Christop, Mardaryev, Andrei N, Poterlowicz, Krzyszto, Sharova, Tatyana, Aziz, Ahmar, Sharpe, David T, Botchkareva, Natalia, Sharov, Andrey A
    J Invest Dermatol, 2014;134(3):827-37.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  51. Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions.
    Authors: Brafman D, Phung C, Kumar N, Willert K
    Cell Death Differ, 2013;20(3):369-81.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  52. Cell-cycle control of developmentally regulated transcription factors accounts for heterogeneity in human pluripotent cells.
    Authors: Singh A, Chappell J, Trost R, Lin L, Wang T, Tang J, Matlock B, Weller K, Wu H, Zhao S, Jin P, Dalton S
    Stem Cell Reports, 2013;1(6):532-44.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  53. H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs.
    Authors: Chen, Jiekai, Liu, He, Liu, Jing, Qi, Jing, Wei, Bei, Yang, Jiaqi, Liang, Hanquan, Chen, You, Chen, Jing, Wu, Yaran, Guo, Lin, Zhu, Jieying, Zhao, Xiangjie, Peng, Tianran, Zhang, Yixin, Chen, Shen, Li, Xuejia, Li, Dongwei, Wang, Tao, Pei, Duanqing
    Nat Genet, 2013;45(1):34-42.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  54. Perichondrium phenotype and border function are regulated by Ext1 and heparan sulfate in developing long bones: a mechanism likely deranged in Hereditary Multiple Exostoses.
    Authors: Huegel J, Mundy C, Sgariglia F, Nygren P, Billings P, Yamaguchi Y, Koyama E, Pacifici M
    Dev Biol, 2013;377(1):100-12.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  55. Bone morphogenetic protein-7 (BMP-7) mediates ischemic preconditioning-induced ischemic tolerance via attenuating apoptosis in rat brain.
    Authors: Guan J, Li H, Lv T, Chen D, Yuan Y, Qu S
    Biochem Biophys Res Commun, 2013;441(3):560-6.
    Species: Rat
    Sample Types: In Vivo
  56. Beta-catenin (CTNNB1) induces Bmp expression in urogenital sinus epithelium and participates in prostatic bud initiation and patterning.
    Authors: Mehta V, Schmitz C, Keil K, Joshi P, Abler L, Lin T, Taketo M, Sun X, Vezina C
    Dev Biol, 2013;376(2):125-35.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  57. Integration of multiple signaling regulates through apoptosis the differential osteogenic potential of neural crest-derived and mesoderm-derived Osteoblasts.
    Authors: Li S, Meyer N, Quarto N, Longaker M
    PLoS ONE, 2013;8(3):e58610.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  58. Endocardial to myocardial notch-wnt-bmp axis regulates early heart valve development.
    Authors: Wang, Yidong, Wu, Bingruo, Chamberlain, Alyssa A, Lui, Wendy, Koirala, Pratisth, Susztak, Katalin, Klein, Diana, Taylor, Verdon, Zhou, Bin
    PLoS ONE, 2013;8(4):e60244.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  59. Activation of BMP-Smad1/5/8 signaling promotes survival of retinal ganglion cells after damage in vivo.
    Authors: Ueki Y, Reh TA,
    PLoS ONE, 2012;7(6):e38690.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  60. Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme.
    Authors: Sneddon, Julie B, Borowiak, Malgorza, Melton, Douglas
    Nature, 2012;491(7426):765-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  61. A molecular signature for purified definitive endoderm guides differentiation and isolation of endoderm from mouse and human embryonic stem cells.
    Authors: Wang P, McKnight K, Wong D, Rodriguez R, Sugiyama T, Gu X, Ghodasara A, Qu K, Chang H, Kim S
    Stem Cells Dev, 2012;21(12):2273-87.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  62. An RNA interference screen uncovers a new molecule in stem cell self-renewal and long-term regeneration.
    Authors: Chen T, Heller E, Beronja S, Oshimori N, Stokes N, Fuchs E
    Nature, 2012;485(7396):104-8.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  63. Isolation and propagation of enteric neural crest progenitor cells from mouse embryonic stem cells and embryos.
    Authors: Kawaguchi J, Nichols J, Gierl MS, Faial T, Smith A
    Development, 2010;137(5):693-704.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  64. Regulation of retinal progenitor cell differentiation by bone morphogenetic protein 4 is mediated by the smad/id cascade.
    Authors: Du Y, Xiao Q, Yip HK
    Invest. Ophthalmol. Vis. Sci., 2010;51(7):3764-73.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  65. Self-renewing epiblast stem cells exhibit continual delineation of germ cells with epigenetic reprogramming in vitro.
    Authors: Hayashi K, Surani MA
    Development, 2009;136(21):3549-56.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  66. A concentration-dependent endocytic trap and sink mechanism converts Bmper from an activator to an inhibitor of Bmp signaling.
    Authors: Kelley R, Ren R, Pi X, Wu Y, Moreno I, Willis M, Moser M, Ross M, Podkowa M, Attisano L, Patterson C
    J. Cell Biol., 2009;184(4):597-609.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  67. Postinjury niches induce temporal shifts in progenitor fates to direct lesion repair after spinal cord injury.
    Authors: Sellers DL, Maris DO, Horner PJ
    J. Neurosci., 2009;29(20):6722-33.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  68. BMP inhibition enhances axonal growth and functional recovery after spinal cord injury.
    Authors: Matsuura I, Taniguchi J, Hata K, Saeki N, Yamashita T
    J. Neurochem., 2008;105(4):1471-9.
    Species: Rat
    Sample Types: In Vivo
    Applications: In Vivo
  69. Interaction with human stromal cells enhances CXCR4 expression and engraftment of cord blood Lin(-)CD34(-) cells.
    Authors: Kobune M, Kawano Y, Takahashi S, Takada K, Murase K, Iyama S, Sato T, Takimoto R, Niitsu Y, Kato J
    Exp. Hematol., 2008;36(9):1121-31.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  70. Bone morphogenetic proteins promote gliosis in demyelinating spinal cord lesions.
    Authors: Fuller ML, DeChant AK, Rothstein B, Caprariello A, Wang R, Hall AK, Miller RH
    Ann. Neurol., 2007;62(3):288-300.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  71. Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4.
    Authors: Lin L, Valore EV, Nemeth E, Goodnough JB, Gabayan V, Ganz T
    Blood, 2007;110(6):2182-9.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  72. A discrete period of FGF-induced Erk1/2 signalling is required for vertebrate neural specification.
    Authors: Stavridis MP, Lunn JS, Collins BJ, Storey KG
    Development, 2007;134(16):2889-94.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  73. Short-term BMP-4 treatment initiates mesoderm induction in human embryonic stem cells.
    Authors: Zhang P, Li J, Tan Z, Wang C, Liu T, Chen L, Yong J, Jiang W, Sun X, DU L, Ding M, Deng H
    Blood, 2007;111(4):1933-41.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  74. Long-term self-renewal and directed differentiation of human embryonic stem cells in chemically defined conditions.
    Authors: Yao S, Chen S, Clark J, Hao E, Beattie GM, Hayek A, Ding S
    Proc. Natl. Acad. Sci. U.S.A., 2006;103(18):6907-12.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  75. Expression of the short stature homeobox gene Shox is restricted by proximal and distal signals in chick limb buds and affects the length of skeletal elements.
    Authors: Tiecke E, Bangs F, Blaschke R, Farrell ER, Rappold G, Tickle C
    Dev. Biol., 2006;298(2):585-96.
    Species: Chicken
    Sample Types: In Vivo
    Applications: In Vivo
  76. BMP is an important regulator of proepicardial identity in the chick embryo.
    Authors: Schlueter J, Manner J, Brand T
    Dev. Biol., 2006;295(2):546-58.
    Species: Chicken
    Sample Types: Whole Tissue
    Applications: Bioassay
  77. Activin A is an endogenous inhibitor of ureteric bud outgrowth from the Wolffian duct.
    Authors: Maeshima A, Vaughn DA, Choi Y, Nigam SK
    Dev. Biol., 2006;295(2):473-85.
    Species: Rat
    Sample Types: Whole Tissue
    Applications: Bioassay
  78. Six1 promotes a placodal fate within the lateral neurogenic ectoderm by functioning as both a transcriptional activator and repressor.
    Authors: Brugmann SA, Pandur PD, Kenyon KL, Pignoni F, Moody SA
    Development, 2004;131(23):5871-81.
    Species: Xenopus
    Sample Types: Whole Tissue
    Applications: Bioassay
  79. Analysis of SOX2-expressing cell populations derived from human pluripotent stem cells.
    Authors: Brafman D, Moya N, Allen-Soltero S, Fellner T, Robinson M, McMillen Z, Gaasterland T, Willert K
    Stem Cell Reports, 213;1(5):464-78.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  80. Commercially Available Preparations of Recombinant Wnt3a Contain Non-Wnt Related Activities Which May Activate TGF-beta Signaling.
    Authors: Carthy J, Engstrom U, Heldin C, Moustakas A
    J Cell Biochem, 0;117(4):938-45.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay

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