Syndecan-1/CD138 Antibody - BSA Free

Name: Syndecan-1/CD138 Antibody - BSA Free
Brand: Novus Biologicals
SKU: NBP3-16984
Price: 469 USD
Availability: InStock

Novus Biologicals | Catalog # NBP3-16984

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Product Specifications
Scientific Data
Applications
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

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Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: TSPEPTGLEATAASTSTLPAGEGPKEGEAVVLPEVEPGLTAREQEATPRPRETTQLPTTHLAS

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Syndecan-1/CD138 Antibody - BSA Free

Western Blot: Syndecan-1/CD138 Antibody [NBP3-16984]

Western Blot: Syndecan-1/CD138 Antibody [NBP3-16984] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10; Lane 2: RT4; Lane 3: U-251 MG; Lane 4: Human Plasma; Lane 5: Liver; Lane 6: Tonsil

Immunohistochemistry-Paraffin: Syndecan-1/CD138 Antibody [NBP3-16984]

Immunohistochemistry-Paraffin: Syndecan-1/CD138 Antibody [NBP3-16984] - Staining of human placenta shows high expression.

Immunohistochemistry-Paraffin: Syndecan-1/CD138 Antibody [NBP3-16984]

Immunohistochemistry-Paraffin: Syndecan-1/CD138 Antibody [NBP3-16984] - Analysis in human placenta and cerebral cortex tissues using Anti-SDC1 antibody. Corresponding SDC1 RNA-seq data are presented for the same tissues.

Immunohistochemistry-Paraffin: Syndecan-1/CD138 Antibody [NBP3-16984]

Immunohistochemistry-Paraffin: Syndecan-1/CD138 Antibody [NBP3-16984] - Staining of human cerebral cortex shows low expression as expected.

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Applications for Syndecan-1/CD138 Antibody - BSA Free

Application

Recommended Usage

Immunohistochemistry

1:200 - 1:500

Immunohistochemistry-Paraffin

1:200 - 1:500

Western Blot

0.04-0.4 ug/ml

Application Notes

For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Syndecan-1/CD138

CD138, also known as Syndecan-1, is a transmembrane heparin sulfate proteoglycan that binds type I collagen. The relative molecular mass of CD138 is found to vary between 20-95 kDa due to the presence of a variable number of GAG modifications on each CD138 molecule. This protein appears to mediate binding of cells to the extracellular matrix. Among mature tissues, CD138 is expressed on simple and stratified epithelia, endothelial cells, and fibroblasts. (2,3) While stratified keratinocytes express CD138, their malignant transformation suppresses CD138 expression. Wound repair processes alter patterns of CD138 expression. Among hematopoietic cells, CD138 is expressed by immunoglobulin-negative pre-B cells in the bone marrow, immature B cells and by terminally differentiated plasma cells in lymphoid organs. CD138 expression has not been observed on mature, circulating peripheral B lymphocytes, however. (4-7) CD138 is also strongly expressed by multiple myeloma-derived cell lines and elevated levels of CD138 are present in the serum of patients with multiple myeloma, a negative prognostic indicator for the disease. (8)

Alternate Names

CD138, SDC1, Syndecan1

Gene Symbol

SDC1

Additional Syndecan-1/CD138 Products

Product Documents for Syndecan-1/CD138 Antibody - BSA Free

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Certificate of Analysis

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Product Specific Notices for Syndecan-1/CD138 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.