Receptors in the Jak/STAT Pathway

The Jak/STAT pathway is an intracellular signaling pathway that mediates the effects of a large number of cytokines and growth factors. These compounds generally bind to receptors that lack intrinsic kinase activity and thus utilize intracellular enzymes to initiate downstream signaling. Activators of the Jak/STAT signaling pathway include type I/II Interferons, the IL-6, IL-10, IL-12, Common gamma Chain, and Common beta Chain families of cytokines, and numerous growth factors that signal through homodimeric receptors, receptor tyrosine kinases, and G protein-coupled receptors. This signaling pathway regulates red blood cell production, immune cell proliferation and differentiation, and inflammatory responses. The receptors listed below have been shown to activate the Jak/STAT pathway.