373 results for "PDGF R beta" in Products
PDGF R beta Products
PDGF R beta is a transmembrane receptor tyrosine kinase (RTK) that primarily binds to the PDGF-BB isoform of the growth factor. Ligand binding induces receptor homodimerization or heterodimerization with PDGF R alpha followed by autophosphorylation and signal transduction. PDGF receptor signaling is attenuated by SHP-2 phosphatase activity and by receptor endocytosis and lysosomal degradation. The expression of the alpha and beta receptors is independently regulated in various cell types. A soluble splice variant of PDGF R beta binds PDGF with high affinity and functions as a potent PDGF antagonist.
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | IHC, WB, Dual ISH-IHC |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | IHC, WB, B/N, Flow, CyTOF-ready |
Contains 4 sets of 2 membranes - each spotted in duplicate with antibodies against 37 different kinases and 2 related total proteins
| Reactivity: | Human |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #PR7212 |
| Applications: | WB, Flow, IP |
Contains 4 membranes - each spotted in duplicate with 49 different RTK antibodies
| Reactivity: | Human |
| Reactivity: | Human |
| Source: | NS0 |
| Accession #: | P09619 |
| Applications: | Bioactivity |
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | IHC, WB |
| Reactivity: | Mouse |
| Details: | Rat IgG2a Kappa Monoclonal Clone #APB5 |
| Applications: | IHC, Flow, MA |
![Flow Cytometry: PDGF R beta Antibody (APB5) - BSA Free [NBP1-43349]](https://resources.rndsystems.com/images/products/PDGF-R-beta-Antibody-APB5-Flow-Cytometry-NBP1-43349-img0004.jpg "Flow Cytometry: PDGF R beta Antibody (APB5) - BSA Free [NBP1-43349]")
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #PR7212 |
| Applications: | Flow |
Recombinant Monoclonal Antibody.
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Monoclonal Clone #1210B |
| Applications: | WB, ICC/IF, Simple Western |
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG1 Monoclonal Clone #OTI1E8 |
| Applications: | IHC, WB, ICC/IF |
![Western Blot: PDGF R beta Antibody (OTI1E8) [NBP2-46361]](https://resources.rndsystems.com/images/products/PDGF-R-beta-Antibody-OTI1E8-Western-Blot-NBP2-46361-img0009.jpg "Western Blot: PDGF R beta Antibody (OTI1E8) [NBP2-46361]")
| Reactivity: | Human |
| Applications: | ELISA |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, Simple Western |
| Reactivity: | Human |
| Assay Range: | 250-16000 pg/mL |
| Applications: | ELISA |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #61520 |
| Applications: | WB |
Potent and selective v-Abl tyrosine kinase inhibitor; also inhibits PDGFR and c-kit
| Alternate Names: | Gleevec,CGP 57148B |
| Chemical Name: | 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide methanesulfonate |
| Purity: | ≥98% |
Potent VEGFR, PDGFR and FGFR inhibitor
| Chemical Name: | Methyl (Z)-3-[[[4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene]-2-oxoindoline-6-carboxylate |
| Purity: | ≥98% |
| Reactivity: | Mouse |
| Source: | NS0 |
| Accession #: | P05622 |
| Applications: | Bioactivity |
| Reactivity: | Mouse, Rat |
| Details: | Mouse IgG1 Monoclonal Clone #42G12 |
| Applications: | IHC, WB, Func, Mycoplasma |
![Western Blot: PDGF R beta Antibody (42G12) [NBP1-19191]](https://resources.rndsystems.com/images/products/PDGF-R-beta-Antibody-42G12-Western-Blot-NBP1-19191-img0005.jpg "Western Blot: PDGF R beta Antibody (42G12) [NBP1-19191]")
c-Fms inhibitor; suppresses osteolysis and osteoclast accumulation
| Chemical Name: | N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]-2-methoxyphenyl]-N'-[1-(2-thiazolyl)ethyl]urea |
| Purity: | ≥97% |
Potent and selective PDGFRβ inhibitor
| Chemical Name: | 5-[1,2-Dihydro-2-oxo-6-phenyl-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid |
| Purity: | ≥98% |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Mouse |
| Details: | Rat IgG1 Monoclonal Clone #182106 |
| Applications: | WB |
| Reactivity: | Mouse |
| Source: | NS0 |
| Accession #: | P05622 |
| Applications: | Bioactivity |
| Reactivity: | Rat |
| Source: | NS0 |
| Accession #: | Q05030.2 |
| Applications: | Bioactivity |
