7 results for "G Protein (Heterotrimeric) Inhibitors Small Molecules and Peptides" in Products
G Protein (Heterotrimeric) Inhibitors Small Molecules and Peptides
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an α-, β- and γ-subunit and is bound to GDP in the 'off' state. Ligand binding to a 7-TM receptor causes a conformational change in the receptor, which detaches the G protein. This switches the G protein to an 'on' state, allowing GTP to displace GDP, thus Gα can activate second messenger signaling cascades.
There are several types of Gα ...
Inhibits Gs and stimulates Gi activity
| Purity: | ≥95% |
Catalyzes ADP-ribosylation of Gi, Go and Gt
Inhibitor of Gβ/γ signaling
| Chemical Name: | 3',4',5',6'-Tetrahydroxyspiro[isobenzofuran-1(3H),9'-(9H)xanthen]-3-one |
| Purity: | ≥95% |
Epac inhibitor
| Chemical Name: | α-[(2-(3-Chlorophenyl)hydrazinylidene]-5-(1,1-dimethylethyl)-β-oxo-3-isoxazolepropanenitrile |
| Purity: | ≥98% |
Potent and selective GRK2/3 inhibitor
| Chemical Name: | 3-[[[4-Methyl-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]methyl]amino]-N-[[2-(trifluoromethyl)phenyl]methyl]benzamide |
| Purity: | ≥98% |
Selective and competitive P2X1 antagonist
| Chemical Name: | 8,8'-[carbonylbis(imino-3,1-phenylenecarbonylimino)]bis-1,3,5-naphthalene-trisulphonic acid, hexasodium salt |
Inhibitor of ligand binding to G-protein-coupled receptors
| Chemical Name: | N-(2,3-Diphenyl-1,2,4-thiadiazol-5(2H)-ylidene)methanamine hydrobromide |
| Purity: | ≥98% |
