8 results for "Inward Rectifier Potassium Channel Blockers" in Products
Inward Rectifier Potassium Channel Blockers
The inward-rectifier potassium channel family (also known as 2-TM channels) include the strong inward-rectifier channels (Kir2.x), the G-protein-activated inward-rectifier channels (Kir3.x) and the ATP-sensitive channels (Kir6.x), which combine with sulphonylurea receptors (SUR).
Structurally, the pore-forming subunit of Kir channels is the α-subunit. It contains a single pore domain between two membrane spanning regions. Four α-subunits combine to form a tetramer, with the pore domain of each subunit contributing to the structure of the central pore. Heteromeric channels can also be formed within subfamilies, e.g. Kir3.2 with Kir3.3.
Kir6 (KATP) channel blocker
| Alternate Names: | Glyburide |
| Chemical Name: | 5-Chloro-N-[2-[4-[[[(Cylcohexylamino)carbonyl]amino]sulphonyl]phenyl]ethyl]-2-methoxybenzamide |
| Purity: | ≥98% |
Kir6 blocker; non-hydrolyzable AMP analog
| Chemical Name: | Adenosine-5'-[(β,γ)-imido]triphosphate tetralithium salt |
| Purity: | ≥90% |
Selective blocker of inward-rectifier K+ channels
| Purity: | ≥95% |
Kir2 channel blocker
| Chemical Name: | N-[(4-Methoxyphenyl)methyl]-1-naphthalenemethanamine hydrochloride |
| Purity: | ≥98% |
Kir 7.1 inhibitor; also inhibits Kir 6.2
| Chemical Name: | Isopropyl (1-((5-chloro-8-hydroxyquinolin-7-yl)methyl)piperidin-4-yl)carbamate |
| Purity: | ≥98% |
Kir6 (KATP) channel blocker
| Alternate Names: | AG-EE 623ZW |
| Chemical Name: | 2-Ethoxy-4-[2-[[(1S)-3-methyl-1-[2-(1-piperidinyl)phenyl]butyl]amino]-2-oxoethyl]benzoic acid |
| Purity: | ≥98% |
Kir6 (KATP) blocker; displays high affinity for SUR1/Kir6.2 channels
| Alternate Names: | A-4166,Senaglinide |
| Chemical Name: | N-[[4-(1-Methylethyl)cyclohexyl]carbonyl]-D-phenylalanine |
Kir4.1 blocker
| Chemical Name: | 2-(2-Bromo-4-isopropylphenoxy)-N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamide |
| Purity: | ≥98% |
