12 results for "Jak2 Small Molecules and Peptides" in Products
Jak2 Small Molecules and Peptides
Jak1, Jak 2, and Jak3 belong to the Janus Kinases family of protein tyrosine kinases that couple to cytokine receptors once activated by their corresponding ligands. Activation of Jak family members occurs via phosphorylation at two adjacent tyrosine residues as well as potentially one or more serine residues. Jaks activate members of the STAT fami...
Potent, selective inhibitor of MEK1 and 2
| Chemical Name: | 1,4-Diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene |
Potent and selective JAK1/JAK2 inhibitor; orally bioavailable
| Alternate Names: | INCB018424 |
| Chemical Name: | (3R)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile |
| Purity: | ≥98% |
Potent JAK inhibitor
| Alternate Names: | Tofacitinib citrate |
| Chemical Name: | (3R,4R)-4-Methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-β-oxo-1-piperidinepropanenitrile citrate |
| Purity: | ≥98% |
EGFR-kinase inhibitor. Also JAK2, JAK3 inhibitor
| Alternate Names: | Tyrphostin AG 490 |
| Chemical Name: | (E)-2-Cyano-3-(3,4-dihydrophenyl)-N-(phenylmethyl)-2-propenamide |
| Purity: | ≥98% |
JAK2, FLT3 and TrkA inhibitor; also inhibits AurA and AurB
| Alternate Names: | CEP-701 |
| Chemical Name: | (9S,10S,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-10-(hydroxymethyl)-9-methyl-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one |
| Purity: | ≥98% |
JAK2/STAT3 signaling pathway inhibitor
| Chemical Name: | (1R,5R,6R,7S)-rel-4-Oxo-8-(phenylmethyl)-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylic acid 6,7-dimethyl ester |
| Purity: | ≥98% |
Phosphate salt of Ruxolitinib (Cat. No. 7064); potent and selective JAK1/JAK2 inhibitor
| Chemical Name: | (3R)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile phosphate |
| Purity: | ≥98% |
Highly potent JAK1 and JAK2 inhibitor; also inhibits JAK3 and Tyk2
| Alternate Names: | INCB 28050 |
| Chemical Name: | 1-(Ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-azetidineacetonitrile |
| Purity: | ≥98% |
Potent and selective JAK2 inhibitor; antiangiogenic
| Chemical Name: | 5-Chloro-N2-[(1S)-1-(5-fluoro-2-pyrimidinyl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)-2,4-pyrimidine-2,4-diamine |
| Purity: | ≥98% |
Selective JAK2 Degrader (PROTAC®)
| Chemical Name: | 4-((4-(1-(3-(Cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N-(2-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)ethyl)benzamide trifluoroacetate |
| Purity: | ≥98% |
Potent and selective JAK2/3 Degrader (PROTAC®)
| Chemical Name: | 4-((4-(1-(3-(Cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N-(3-(4-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)propyl)benzamide |
| Purity: | ≥97% |
Potent pan-JAK inhibitor; induces intermediate mesoderm; cell-permeable
| Alternate Names: | JAK inhibitor I |
| Chemical Name: | 2-(1,1-Dimethylethyl)-9-fluoro-1,6-dihydro-7H-benz[h]imidazo[4,5-f]isoquinolin-7-one |
| Purity: | ≥98% |
