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7 results for "P2X7/P2RX7" in Products
P2X7/P2RX7 Products
P2RX7 belongs to the family of purinoceptors for ATP. It functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. P2RX7 antagonists have emerged as novel therapeutics for the treatment of acute inflammation, pain and fever, with wider anti-inflammatory activity than currently used cyclooxygenase inhibitors.
Competitive P2X7 antagonist
| Chemical Name: | 3-[[5-(2,3-Dichlorophenyl)-1H-tetrazol-1-yl]methyl]pyridine hydrochloride |
| Purity: | ≥98% |
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Potent and selective P2X7 antagonist
| Chemical Name: | N-[1-[[(Cyanoamino)(5-quinolinylamino)methylene]amino]-2,2-dimethylpropyl]-3,4-dimethoxybenzeneacetamide |
| Purity: | ≥97% |
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Non-competitive P2X7 antagonist
| Chemical Name: | 4-[(2S)-2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl] phenyl isoquinolinesulfonic acid ester |
| Purity: | ≥98% |
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Potent and selective human P2X7 antagonist
| Chemical Name: | 3-[1-[[(3'-Nitro[1,1'-biphenyl]-4-yl)oxy]methyl]-3-(4-pyridinyl)propyl]-2,4-thiazolidinedione |
| Purity: | ≥98% |
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Potent P2X7 antagonist
| Chemical Name: | N-[2-[[2-[(2-Hydroxyethyl)amino]ethyl]amino]-5-quinolinyl]-2-tricyclo[3.3.1.13,7]dec-1-ylacetamide dihydrochloride |
| Purity: | ≥98% |
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Potent and selective P2X7 antagonist
| Chemical Name: | N-Cyano-N"-[(1S)-1-phenylethyl]-N'-5-quinolinyl-guanidine |
| Purity: | ≥98% |
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Potent and selective P2X7 antagonist; brain penetrant
| Chemical Name: | 2-(Phenylthio)-N-[[tetrahydro-4-(4-phenyl-1-piperazinyl)-2H-pyran-4-yl]methyl-3-pyridinecarboxamide |
| Purity: | ≥98% |
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