12 results for "ras-gtpase-inhibitors&view=expanded" in Products

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Zoledronic Acid

Catalog #: 6111
Citations (5)
Product Documents

Potent farnesyl diphosphate (FPP) synthase inhibitor

Alternate Names: Zometa
Chemical Name: [1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic acid
Purity: ≥98%
Potent farnesyl diphosphate (FPP) synthase inhibitor

EHT 1864

Catalog #: 3872
(1)
Citations (116)
Product Documents

Potent Rac family inhibitor

Chemical Name: 5-(5-(7-(Trifluoromethyl)quinolin-4-ylthio)pentyloxy)-2-(morpholinomethyl)-4H-pyran-4-one dihydrochloride
Purity: ≥98%
Potent Rac family inhibitor

ML 210

Catalog #: 6429
Citations (6)
Product Documents

Selectively kills mutant HRAS-expressing cells; glutathione peroxidase inhibitor; induces ferroptosis

Chemical Name: [4-[Bis(4-chlorophenyl)methyl]-1-piperazinyl](5-methyl-4-nitro-3-isoxazolyl)methanone
Purity: ≥98%
Selectively kills mutant HRAS-expressing cells; glutathione peroxidase inhibitor; induces ferroptosis

Fendiline Hydrochloride

Catalog #: 6407
Citations (4)
Product Documents

Inhibits KRas localization to the plasma membrane; also L-type calcium channel blocker

Chemical Name: N-(3,3-Diphenylpropyl)-α-methylbenzylamine hydrochloride
Purity: ≥98%
Inhibits KRas localization to the plasma membrane; also L-type calcium channel blocker

GNF 7

Catalog #: 5607
Citations (1)
Product Documents

Ras signaling inhibitor; inhibits Ack1 and GCK

Chemical Name: N-[3-[1,4-Dihydro-1-methyl-7-[(6-methyl-3-pyridinyl)amino]-2-oxopyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl]-3-(trifluoromethyl)benzamide
Purity: ≥98%
Ras signaling inhibitor; inhibits Ack1 and GCK

Deltarasin

Catalog #: 5424
Citations (3)
Product Documents

High affinity PDEδ-KRas interaction inhibitor; binds to PDEδ

Chemical Name: 2-[4-[(2S)-2-(2-Phenyl-1H-benzimidazol-1-yl)-2-(4-piperidinyl)ethoxy]phenyl]-1-(phenylmethyl)-1H-benzimidazole trihydrochloride
Purity: ≥98%
High affinity PDEδ-KRas interaction inhibitor; binds to PDEδ

BC-LI-0186

Catalog #: 6791
Citations (1)
Product Documents

Leucyl-tRNA synthase (TRS)/Ras-related GTP-binding protein D (RagD) interaction inhibitor

Chemical Name: 4-[2,5-Dihydro-2,3-dimethyl-4-(1-methylethyl)-5-oxo-1H-pyrazol-1-yl]-N-(2-phenoxyethyl)benzenesulfonamide
Purity: ≥98%
Leucyl-tRNA synthase (TRS)/Ras-related GTP-binding protein D (RagD) interaction inhibitor

AMG 510

Catalog #: 7713
Citations (1)
Product Documents

Potent and selective KRASG12C inhibitor

Alternate Names: Sotorasib
Chemical Name: (1R)-6-Fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-4-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-2(1H)-one
Purity: ≥98%
Potent and selective KRASG12C inhibitor

MRTX 849

Catalog #: 7488
Product Documents

Mutation-selective inhibitor of KRASG12C

Alternate Names: Adagrasib
Chemical Name: 4-[7-(8-Chloro-1-naphthalenyl)-5,6,7,8-tetrahydro-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidin-4-yl]-1-(2-fluoro-1-oxo-2-propen-1-yl)-(2S)-2-piperazineacetonitrile
Purity: ≥98%
Mutation-selective inhibitor of KRASG12C

VVD 844

Catalog #: 8952
Product Documents

Potent covalent inhibitor of the RAS domain of the PI3K/p110α interaction

Chemical Name: 5-((1R,2S,5S)-2-(2-Chloro-3-fluorophenyl)-3-azabicyclo[3.1.0]hexan-3-yl)-N-((R,E)-4-(methylsulfonyl)but-3-en-2-yl)pyrazine-2-carboxamide
Purity: ≥98%
Potent covalent inhibitor of the RAS domain of the PI3K/p110α interaction
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