10 results for "TRPC Channel Blockers Small Molecules and Peptides" in Products
TRPC Channel Blockers Small Molecules and Peptides
TRPC channels are complexes formed by four subunits, each with 6-transmembrane domains and several common features such as 3 or 4 ankyrin repeats in the N-terminal and a TRP box motif at proximal C-terminal. These cation channels are activated, to varying extents, by phospholipase C signaling pathway components, downstream of Gq/11 G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs). Activation of TRPC channels leads to cation influx, membrane depolarization and elevation ...
Selective TRPC3 inhibitor
| Chemical Name: | 1-[4-[(2,3,3-Trichloro-1-oxo-2-propen-1-yl)amino]phenyl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid |
| Purity: | ≥98% |
TRPC1 and TRPC6 inhibitor; inhibits mechanosensitive ion channels
| Purity: | ≥95% |
TRPC channel inhibitor; also inhibits store-operated Ca2+ entry
| Chemical Name: | 1-[2-(4-Methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl-1H-imidazole hydrochloride |
| Purity: | ≥98% |
TRPC1/6 and Piezo2 inhibitor; resistant to proteolytic digestion
| Purity: | ≥95% |
Potent and selective TRPC6 and TRPC3 antagonist
| Chemical Name: | [2-[(4-Chloro-2-fluorophenyl)amino]-5-methyl-4-thiazolyl][(2S,3S)-2,3-dimethyl-1-piperidinyl]methanone |
| Purity: | ≥98% |
Selective TRPC4 inhibitor
| Chemical Name: | 4-Methyl-2-(1-piperidinyl)quinoline |
| Purity: | ≥99% |
TRPC4 and TRPC5 inhibitor; antidepressant and anxiolytic
| Chemical Name: | N-Butyl-1H-benzimidazol-2-amine hydrochloride |
| Purity: | ≥99% |
Potent TRPC6 inhibitor
| Chemical Name: | 4-[[(1R,2R)-2-[(3R)-3-Amino-1-piperidinyl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chlorobenzonitrile dihydrochloride |
| Purity: | ≥98% |
Selective TRPC5 inhibitor
| Chemical Name: | N-(2-Furanylmethyl)-1-(phenylmethyl)-1H-benzimidazol-2-amine |
| Purity: | ≥98% |
Selective TRPC3 inhibitor
| Chemical Name: | N-[4-[3,5-bis(Trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-4-methylbenzenesulfonamide |
| Purity: | ≥98% |
