B-Raf Antibody (336016) [HRP]

Name: B-Raf Antibody (336016) [HRP]
Brand: Novus Biologicals
SKU: FAB3424H
Price: 519 USD
Availability: InStock

Novus Biologicals | Catalog # FAB3424H

Submit a review

Product Documents

View Available Conjugates

100% Guarantee

Product Specifications
Applications
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Western Blot

Label

HRP

Antibody Source

Monoclonal Mouse IgG_2A Clone # 336016

View all B-Raf Primary Antibodies »

Product Specifications

Immunogen

E. coli-derived recombinant human B-Raf
Met1-His766
Accession # P15056

Specificity

Detects human, mouse, and rat B-Raf. No cross-reactivity with recombinant human Raf-1 is observed. Cross-reactivity with A-Raf has not been tested.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG_2A

Applications for B-Raf Antibody (336016) [HRP]

Application

Recommended Usage

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Application Notes

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Formulation

PBS

Preservative

No Preservative

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: B-Raf

B-Raf, also know as c-Rmil, is a Serine/Threonine protein kinase member of the Raf family which includes Raf-1 and A-Raf. B-Raf is involved in the transduction of mitogenic signals from the cell membrane to the nucleus (1). Composed of three conserved region (CR1, CR2, CR3) B-Raf is expressed primarily in the brain and in the nervous system (2). It has been observed that MAPK is activated by B-Raf in response to nerve growth factor (3). More than 60% of malignant melanomas were found to contain a specific mutation, B-Raf (V599E) the product of which possesses constitutive kinase activity (4). Mutations in B-Raf have also been identified in lung cancer and non-Hodgkin lymphoma.

Long Name

v-Raf Murine Sarcoma Viral Oncogene Homolog B1

Alternate Names

BRaf, BRAF1, RAFB1

Gene Symbol

BRAF

Additional B-Raf Products

Product Documents for B-Raf Antibody (336016) [HRP]

Download Product Datasheets

Download SDS

Product Specific Notices for B-Raf Antibody (336016) [HRP]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.