GFRAL is A Novel GDF-15 Receptor with a Putative Role in Appetite Disorders

GFRAL a novel GDF-15 Receptor

Growth Differentiation Factor 15 (GDF-15) has long been recognized as a circulating biomarker for a range of human disorders, and elevated levels have been associated with suppression of appetite. The receptor for this effect was recently revealed in four publications to be GDNF receptor-alpha-like (GFRAL), a distant member of the GDNF R family of proteins (1-4). The full receptor complex is composed of both Ret tyrosine kinase and GFRAL dimers. This newly discovered role for GFRAL places it in a position to act as a drug target for appetite regulation and obesity. This is an exciting finding given the impact obesity-related disorders have on economic and social well-being. Finally, GFRAL could also be targeted in a number of other contexts, including: cancer, heart disease, diabetes, endocrine disorders, and brain attack.

R&D Systems is pleased to offer purified His tagged or Fc-tagged Recombinant Human GFRAL to assist in studies designed to gain a further understanding of GFRAL activity. These new proteins bind to Recombinant GDF-15 in the pg/mL range.

Recombinant Human GDF-15 protein
Figure 1: His-tagged GFRAL binds GDF-15. When Recombinant Human GFR alpha-like (Catalog # 9647-GR) is immobilized at 0.1 µg/mL, 100 µL/well, it binds to Recombinant Human GDF-15 (Catalog # 9279-GD) with an ED50 of 0.15-0.9 ng/mL.
Recombinant Human GDF-15 protein
Figure 2. Fc Chimera GFRAL binds GDF-15. When Recombinant Human GFR alpha-like Fc Chimera (Catalog # 9697-GR) is immobilized at 0.1 µg/mL, 100 µL/well, it binds to Recombinant Human GDF-15 (Catalog # 9279-GD) with an ED50 of 0.1-0.7 ng/mL.

Don’t forget that we span the research workflow. Explore GFRAL-related products from all
Bio-Techne brands!

R&D Systems Novus Biologicals Protein Simple
GFRAL cDNA Human GFRAL RNAi Human GDF-15 Simple Plex Assay
GFRAL Antibodies GFRAL Antibodies Use Ella to run Simple Plex Assay
GDF-15 Protein and Enzymes GFRAL Protein Antigen  
GDF-15 Antibodies GDF-15 Antibodies   
GDF-15 Luminex Assays GDF-15 Lysates  
Proteome Profiler Antibody Arrays Ret RNAi  
Ret cDNA Ret Antibodies  
Ret Antibodies Ret Proteins  
Ret Proteins Ret Lysates  
Proteome Profiler RTK Arrays Vectors  
Advanced Cell Diagnostics Tocris Bioscience
GFRAL RNAscope® Probes Ret inhibitors
GDF-15 RNAscope Probes  


  1. Emmerson, P.J. et al. (2017) Nat. Med. 23:1215.
  2. *Mullican, S.E. et al. (2017) Nat. Med. 23:1150.
  3. Yang, L. et al. (2017). Nat. Med. 23:1158.
  4. Hsu, J.Y. et al. (2017) Nature 550:255.