Human BMPR-IA/ALK-3 PE-conjugated Antibody Summary
Gln24-Arg152
Accession # P36894
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of BMPR‑IA/ALK‑3 in PC‑3 Human Cell Line by Flow Cytometry. PC-3 human prostate cancer cell line was stained with Goat Anti-Human BMPR-IA/ALK-3 PE-conjugated Antigen Affinity-purified Polyclonal Antibody (Catalog # FAB346P, filled histogram) or isotype control antibody (Catalog # IC108P, open histogram). View our protocol for Staining Membrane-associated Proteins.
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Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: BMPR-IA/ALK-3
Cellular responses to Bone Morphogenetic Proteins (BMPs) have been shown to be mediated by the formation of hetero-oligomeric complexes of the type I and type II serine/threonine kinase receptors. BMP Receptor 1A (BMPR-1A), also known as Activin Receptor-Like Kinase 3 (ALK-3), is one of seven known type I serine/threonine kinases that are required for the signal transduction of TGF-beta family cytokines. In contrast to the TGF-beta receptor system in which the type I receptor does not bind TGF-beta in the absence of the type II receptor, type I receptors involved in BMP signaling (including BMPR-IA, BMPR-IB/ALK-6, and ActR-I/ALK-2) can independently bind the various BMP family proteins in the absence of type II receptors. Recombinant soluble BMPR-IA binds BMP-4 with high-affinity in solution and is a potent BMP-4 antagonist in vitro. BMPR-IA is ubiquitously expressed during embryogenesis. In adult tissues, BMPR-IA mRNA is also widely distributed with the highest expression levels found in skeletal muscle. The extracellular domain of BMPR-IA shares little amino acid sequence identity with the other mammalian ALK type I receptor kinases, but the cysteine residues are conserved. Human and mouse BMPR-IA are highly conserved and share 98% sequence identity.
Product Datasheets
Citations for Human BMPR-IA/ALK-3 PE-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Dupuytren's Disease Is Mediated by Insufficient TGF-?1 Release and Degradation
Authors: Oezel, L;Wohltmann, M;Gondorf, N;Wille, J;Güven, I;Windolf, J;Thelen, S;Jaekel, C;Grotheer, V;
International journal of molecular sciences
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Osteogenic differentiation of human mesenchymal stromal cells and fibroblasts differs depending on tissue origin and replicative senescence
Authors: V Grotheer, N Skrynecki, L Oezel, J Grassmann, J Windolf, CV Suschek
Scientific Reports, 2021-06-07;11(1):11968.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
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