Human Calsyntenin-2 Antibody

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Human Calsyntenin-2 Antibody in Immunohistochemistry
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Human Calsyntenin-2 Antibody Summary

Species Reactivity
Detects human Calsyntenin-2 in direct ELISAs. In direct ELISAs, less than 1% cross-reactivity with recombinant human (rh) Calsyntenin-1 and rhCalsyntenin-3 is observed.
Polyclonal Sheep IgG
Antigen Affinity-purified
Mouse myeloma cell line NS0-derived recombinant human Calsyntenin-2
Ser21-Thr834 (Val366Ile)
Accession # Q9H4D0
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.


Recommended Concentration
5-15 µg/mL
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Data Example

Immunohistochemistry Calsyntenin‑2 in Human Brain. View Larger

Calsyntenin‑2 in Human Brain. Calsyntenin-2 was detected in immersion fixed paraffin-embedded sections of human brain (cortex) using Sheep Anti-Human Calsyntenin-2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF5480) at 10 µg/mL overnight at 4 °C. Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (Catalog # CTS013). Tissue was stained using the Anti-Sheep HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS019) and counterstained with hematoxylin (blue). Specific staining was localized to neurons. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.

Reconstitution Calculator

Reconstitution Calculator

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Preparation and Storage

Sterile PBS to a final concentration of 0.2 mg/mL.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Size / Price
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Calsyntenin-2

Calsyntenin-2 (CS-2) is a 120-135 kDa member of the Alcadein family of molecules. It is expressed in the ER/Golgi, and the plasma membranes of almost all neurons. It is a calcium-binding protein that interacts with APP and X11L. In this regard, it appears to regulate APP cleavage and gene activation, and likely impacts post-synaptic signaling. Notably, when cleaved in a manner similar to APP, its intracellular fragment antagonizes AICD gene activation. Mature human CS-2 is a 935 amino acid (aa) type I transmembrane protein. It contains two cadherin domains (aa 44-280) in its extracellular region (aa 21-831) and a 103 aa cytoplasmic tail. Proteolytic cleavage by ADAM10 occurs between His803 and Leu804 to generate a 105-110 kDa extracellular fragment. Additional processing of the transmembrane fragment by gamma -secretase creates a 3 kDa fragment (aa 804-834) plus a 25 kDa cytoplasmic protein. Potential isoform variants show a premature truncation after Gln608, and the use of an alternative start site at Met409. Over aa 21-834, human CS-2 shares 95% aa identity with mouse CS-2.

Entrez Gene IDs
64084 (Human); 64085 (Mouse); 171394 (Rat)
Alternate Names
alcadein gamma; Alcadein-gamma; alcagamma; ALC-GAMMA; cadherin-related family member 13; calsyntenin 2; Calsyntenin2; Calsyntenin-2; CDHR13; CLSTN2; CS2; CS2alcadein-gamma; CSTN2; FLJ39113; FLJ39499; MGC119560

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Cell and Tissue Staining Kits

Immunohistochemistry Reagents

Isotype Controls

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Secondary Antibodies

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