Human CX3CR1 Fluorescein-conjugated Antibody
Human CX3CR1 Fluorescein-conjugated Antibody Summary
Met1-Thr31, Leu91-Lys103, Thr168-Thr195, Lys257-Leu273
Accession # NP_001328
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Detection of CX3CR1 in Human Blood Monocytes by Flow Cytometry. Human peripheral blood monocytes were stained with Mouse Anti-Human CX3CR1 Fluorescein-conjugated Monoclonal Antibody (Catalog # FAB5204F, filled histogram) or isotype control antibody (Catalog # IC002F, open histogram). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
CX3CR1 is a 40 kDa seven transmembrane chemokine receptor that is expressed on several T cell subsets, monocytes, macrophages, microglia, and epithelial cells. CX3CR1 binding to membrane bound or soluble CX3CR1/Fractalkine promotes inflammatory responses by inducing monocyte adhesion to endothelial cells and macrophage activation. CX3CR1 polymorphisms are associated with the development of chronic inflammatory disorders. Alternately spliced isoforms have extended N-terminal extracellular regions that increase the potency of CX3CR1 as a fusion co-receptor for HIV-1. Human CX3CR1 shares 82% amino acid sequence identity with mouse and rat CX3CR1.
Citation for Human CX3CR1 Fluorescein-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
1 Citation: Showing 1 - 1
CX3CL1/CX3CR1 and CCL2/CCR2 Chemokine/Chemokine Receptor Complex in Patients with AMD.
Authors: Falk M, Singh A, Faber C, Nissen M, Hviid T, Sorensen T
PLoS ONE, 2014;9(12):e112473.
Sample Types: Whole Cells
Applications: Flow Cytometry
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