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OR
  • Assay Type
    Solid Phase Sandwich ELISA
  • Format
    96-well strip plate
  • Assay Length
    3.5 hours
  • Sensitivity
    7.5 pg/mL
  • Assay Range
    31.20 - 2,000 pg/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma, Citrate Plasma,)
  • Specificity
    Natural and recombinant human IL-8
  • Cross-reactivity
    < 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
  • Interference
    No significant interference observed with available related molecules.
Control Available
Product Summary
The Quantikine Human IL-8 Immunoassay is a 3.5 hour solid phase ELISA designed to measure human IL-8 in cell culture supernates, serum, and plasma. It is based on antibodies raised against the 72 aa variant of human IL-8 derived from E. coli. It is calibrated with the same recombinant factor. This immunoassay accurately quantitates recombinant human IL-8. Measurement of natural human IL-8 or the 77 aa variant of human IL-8 gave results parallel to the standard curves obtained using the E. coli-expressed Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural human IL-8.

Precision
Intra-Assay Precision (Precision within an assay) hree samples of known concentration were tested in separate assays to assess inter-assay precision.
Inter-Assay Precision (Precision between assays Three samples of known concentration were tested on one plate to assess intra-assay precision.
Serum, EDTA Plasma, Heparin Plasma, Citrate Plasma
Intra-Assay Precision Inter-Assay Precision
Sample123123
n202020202020
Mean16852610931965811160
Standard Deviation9.428.670.714.556.670.2
CV%5.65.46.57.49.76.1

Cell Culture Supernates
Intra-Assay Precision Inter-Assay Precision
Sample123123
n202020202020
Mean115386802132410817
Standard Deviation5.31737.910.72842.4
CV%4.64.44.78.16.85.2

Recovery

The recovery of IL-8 spiked to three different levels throughout the range of the assay in various matrices was evaluated.

Sample Type Average % Recovery Range %
Cell Culture Media (n=5) 98 85-114
Citrate Plasma (n=5) 105 95-114
EDTA Plasma (n=5) 103 97-111
Heparin Plasma (n=5) 102 92-107
Serum (n=5) 98 88-106
Linearity
To assess the linearity of the assay, samples were spiked with high concentrations of IL-8 in various matrices and diluted with the appropriate Calibrator Diluent to produce samples with values within the dynamic range of the assay.
Human CXCL8/IL-8 Quantikine ELISA Kit
Background: CXCL8/IL-8

CXCL8 was originally discovered and purified as a neutrophil chemotactic and activating factor. It was also referred to as neutrophil chemotactic factor (NCF), neutrophil activating protein (NAP), monocytederived neutrophil chemotactic factor (MDNCF), T lymphocyte chemotactic factor (TCF), granulocyte chemotactic protein (GCP) and leukocyte adhesion inhibitor (LAI). Many cell types, including monocyte/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, keratinocytes, hepatocytes, chondrocytes, and various tumor cell lines, can produce CXCL8 in response to a wide variety of proinflammatory stimuli such as exposure to IL-1, TNF, LPS, and viruses. CXCL8 is a member of the alpha (CXC) subfamily of chemokines, which also includes platelet factor-4, GRO, and IP10.

CXCL8 is a potent chemoattractant for neutrophils. In addition, CXCL8 also has a wide range of other proinflammatory effects. CXCL8 causes degranulation of neutrophil specific granules and azurophilic granules. CXCL8 induces expression of the cell adhesion molecules CD11/CD18 and enhances the adherence of neutrophils to endothelial cells and subendothelial matrix proteins. Besides neutrophils, CXCL8 is also chemotactic for basophils, T cells and eosinophils. CXCL8 has been reported to be a co-mitogen for keratinocytes and was also shown to be an autocrine growth factor for melanoma cells. CXCL8 was also reported to be angiogenic both in vivo and in vitro.

    • Entrez Gene IDs
      3576 (Human); 396880 (Porcine); 403850 (Canine); 493836 (Feline);
    • Alternate Names
      GCP1; IL8; LAI; MDNCF; NAP1; NCF; TCF; TSG1; 3-10C; AMCF-I; C-X-C motif chemokine 8; CXCL8SCYB8; Emoctakin; GCP-1TSG-1; interleukin 8; K60; LECT; MDNCFb-ENAP; member 8; MONAPGCP1; NAP-1NAP1; Neutrophil-activating protein 1; Protein 3-10C; T cell chemotactic factor; T-cell chemotactic factor;
    Related Research Areas
    Assay Procedure
    Refer to the product for complete assay procedure.

    Bring all reagents and samples to room temperature before use. It is recommended that all samples, standards, and controls be assayed in duplicate.
    1.   Prepare all reagents, standard dilutions, and samples as directed in the product insert.
    2.   Remove excess microplate strips from the plate frame, return them to the foil pouch containing the desiccant pack, and reseal.

    3. 100 µL Assay Diluent
    4.   Add 100 µL of Assay Diluent to each well.

    5. 50 µL Standard, Control, or Sample
    6.   Add 50 µL of Standard, control, or sample to each well. Cover with a plate sealer, and incubate at room temperature for 2 hours.
    7.   Aspirate each well and wash, repeating the process 3 times for a total of 4 washes.

    8. 100 µL Conjugate
    9.   Add 100 µL of Conjugate to each well. Cover with a new plate sealer, and incubate at room temperature for 1 hour.
    10.   Aspirate and wash 4 times.

    11. 200 µL Substrate Solution
    12.   Add 200 µL Substrate Solution to each well. Incubate at room temperature for 30 minutes. PROTECT FROM LIGHT.

    13. 50 µL Stop Solution
    14.   Add 50 µL of Stop Solution to each well. Read at 450 nm within 30 minutes. Set wavelength correction to 540 nm or 570 nm.
    Citations:

    R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

    Showing Results 1 - 10 of 179
    Filter your results:

    Species
    Sample Type
    1. Association between visceral fat, IL-8 and endometrial cancer.
      Authors: Ciortea, Razvan, Mihu, Dan, Mihu, Carmen M
      Anticancer Res, 2014;34(1):379-83.
    2. Thrombin-induced CCAAT/enhancer-binding protein beta activation and IL-8/CXCL8 expression via MEKK1, ERK, and p90 ribosomal S6 kinase 1 in lung epithelial cells.
      Authors: Lin C, Nai P, Bien M, Yu C, Chen B
      J Immunol, 2014;192(1):338-48.
      Species: Human
      Sample Type: Cell Culture Supernates
    3. Mycobacterium bovis bacilli Calmette-Guerin regulates leukocyte recruitment by modulating alveolar inflammatory responses.
      Authors: Andersson M, Lutay N, Hallgren O, Westergren-Thorsson G, Svensson M, Godaly G
      Innate Immun, 2012;18(3):531-40.
      Species: Human
      Sample Type: Cell Culture Supernates
    4. Late SV40 factor (LSF) enhances angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (MMP-9).
      Authors: Santhekadur PK, Gredler R, Chen D
      J. Biol. Chem., 2012;287(5):3425-32.
      Species: Human
      Sample Type: Cell Culture Supernates
    5. TLR4 Protein Contributes to Cigarette Smoke-induced Matrix Metalloproteinase-1 (MMP-1) Expression in Chronic Obstructive Pulmonary Disease.
      Authors: Geraghty P, Dabo AJ, D'Armiento J
      J. Biol. Chem., 2011;286(34):30211-8.
      Species: Human
      Sample Type: Cell Culture Supernates
    6. Mannitol challenge for assessment of airway responsiveness, airway inflammation and inflammatory phenotype in asthma.
      Authors: Wood LG, Powell H, Gibson PG
      Clin. Exp. Allergy, 2010;40(2):232-41.
      Species: Human
      Sample Type: Saliva
    7. Discovery of a novel class of targeted kinase inhibitors that blocks protein kinase C signaling and ameliorates retinal vascular leakage in a diabetic rat model.
      Authors: Grant S, Tran P, Zhang Q, Zou A, Dinh D, Jensen J, Zhou S, Kang X, Zachwieja J, Lippincott J, Liu K, Johnson SL, Scales S, Yin C, Nukui S, Stoner C, Prasanna G, Lafontaine J, Wells P, Li H
      Eur. J. Pharmacol., 2010;627(1):16-25.
      Species: Human
      Sample Type: Cell Culture Supernates
    8. Androgen-regulated expression of arginase 1, arginase 2 and interleukin-8 in human prostate cancer.
      Authors: Gannon PO, Godin-Ethier J, Hassler M, Delvoye N, Aversa M, Poisson AO, Peant B, Alam Fahmy M, Saad F, Lapointe R, Mes-Masson AM
      PLoS ONE, 2010;5(8):e12107.
      Species: Human
      Sample Type: Cell Culture Supernates
    9. Immunomodulation of nasal epithelial cells by Staphylococcus aureus-derived serine proteases.
      Authors: Rudack C, Sachse F, Albert N, Becker K, von Eiff C
      J. Immunol., 2009;183(11):7592-601.
      Species: Human
      Sample Type: Cell Culture Supernates
    10. Uropathogenic Escherichia coli modulates immune responses and its curli fimbriae interact with the antimicrobial peptide LL-37.
      Authors: Kai-Larsen Y, Luthje P, Chromek M, Peters V, Wang X, Holm A, Kadas L, Hedlund KO, Johansson J, Chapman MR, Jacobson SH, Romling U, Agerberth B, Brauner A
      PLoS Pathog., 2010;6(0):e1001010.
      Species: Human
      Sample Type: Urine
    11. Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease.
      Authors: Smith AM, Rahman FZ, Hayee B, Graham SJ, Marks DJ, Sewell GW, Palmer CD, Wilde J, Foxwell BM, Gloger IS, Sweeting T, Marsh M, Walker AP, Bloom SL, Segal AW
      J. Exp. Med., 2009;206(9):1883-97.
      Species: Human
      Sample Type: Cell Culture Supernates
    12. Role of inflammation and insulin resistance in endothelial progenitor cell dysfunction.
      Authors: Desouza CV, Hamel FG, Bidasee K, O'Connell K
      Diabetes, 2011;60(4):1286-94.
      Species: Human
      Sample Type: Cell Culture Supernates
    13. Soluble TLR2 is present in human amniotic fluid and modulates the intraamniotic inflammatory response to infection.
      Authors: Dulay AT, Buhimschi CS, Zhao G, Oliver EA, Mbele A, Jing S, Buhimschi IA
      J. Immunol., 2009;182(11):7244-53.
      Species: Human
      Sample Type: Amniotic Fluid
    14. Crimean Congo hemorrhagic fever virus infects human monocyte-derived dendritic cells.
      Authors: Connolly-Andersen AM, Douagi I, Kraus AA, Mirazimi A
      Virology, 2009;390(2):157-62.
      Species: Human
      Sample Type: Cell Culture Supernates
    15. Dysregulation of stromal derived factor 1/CXCR4 axis in the megakaryocytic lineage in essential thrombocythemia.
      Authors: Salim JP, Goette NP, Lev PR, Chazarreta CD, Heller PG, Alvarez C, Molinas FC, Marta RF
      Br. J. Haematol., 2009;144(1):69-77.
      Species: Human
      Sample Type: Plasma
    16. Particulate matter in cigarette smoke alters iron homeostasis to produce a biological effect.
      Authors: Ghio AJ, Hilborn ED, Stonehuerner JG, Dailey LA, Carter JD, Richards JH, Crissman KM, Foronjy RF, Uyeminami DL, Pinkerton KE
      Am. J. Respir. Crit. Care Med., 2008;178(11):1130-8.
    17. 1, 25 Dihydroxyvitamin D3 modulated cytokine response in pulmonary tuberculosis.
      Authors: Vidyarani M, Selvaraj P, Jawahar MS, Narayanan PR
      Cytokine, 2007;40(2):128-34.
      Species: Human
      Sample Type: Cell Culture Supernates
    18. Securinine, a GABAA receptor antagonist, enhances macrophage clearance of phase II C. burnetii: comparison with TLR agonists.
      Authors: Lubick K, Radke M, Jutila M
      J. Leukoc. Biol., 2007;82(5):1062-9.
      Species: Human
      Sample Type: Cell Culture Supernates
    19. Clarithromycin targets neutrophilic airway inflammation in refractory asthma.
      Authors: Simpson JL, Powell H, Boyle MJ, Scott RJ, Gibson PG
      Am. J. Respir. Crit. Care Med., 2007;177(2):148-55.
      Species: Human
      Sample Type: Sputum
    20. Serum and urine levels of interleukin-8 in patients with non-Hodgkin's lymphoma.
      Authors: Lee HL, Eom HS, Yun T, Kim HJ, Park WS, Nam BH, Moon-Woo S, Lee DH, Kong SY
      Cytokine, 2008;43(1):71-5.
    21. Increased levels of LPS-binding protein in bovine blood and milk following bacterial lipopolysaccharide challenge.
      Authors: Bannerman DD, Paape MJ, Hare WR, Sohn EJ
      J. Dairy Sci., 2003;86(10):3128-37.
      Species: Bovine
      Sample Type: Milk
    22. Complement fragment C5a and inflammatory cytokines in neutrophil recruitment during intramammary infection with Escherichia coli.
      Authors: Shuster DE, Kehrli ME, Rainard P, Paape M
      Infect. Immun., 1997;65(8):3286-92.
    23. Specificity of immunomodulator secretion in urinary samples in response to infection by alpha-hemolysin and CNF1 bearing uropathogenic Escherichia coli.
      Authors: Real JM, Munro P, Buisson-Touati C, Lemichez E, Boquet P, Landraud L
      Cytokine, 2007;37(1):22-5.
      Species: Human
      Sample Type: Urine
    24. MMP-12 induces IL-8/CXCL8 secretion through EGFR and ERK1/2 activation in epithelial cells.
      Authors: Le Quement C, Guenon I, Gillon JY, Lagente V, Boichot E
      Am. J. Physiol. Lung Cell Mol. Physiol., 2008;294(6):L1076-84.
    25. Innate immune activation in neutrophilic asthma and bronchiectasis.
      Authors: Simpson JL, Grissell TV, Douwes J, Scott RJ, Boyle MJ, Gibson PG
      Thorax, 2007;62(3):211-8.
      Species: Human
      Sample Type: Sputum
    26. MAPK pathway mediates EGR-1-HSP70-dependent cigarette smoke-induced chemokine production.
      Authors: Li CJ, Ning W, Matthay MA, Feghali-Bostwick CA, Choi AM
      Am. J. Physiol. Lung Cell Mol. Physiol., 2007;292(5):L1297-303.
    27. Pathogenesis of Ebola hemorrhagic fever in cynomolgus macaques: evidence that dendritic cells are early and sustained targets of infection.
      Authors: Geisbert TW, Hensley LE, Larsen T, Young HA, Reed DS, Geisbert JB, Scott DP, Kagan E, Jahrling PB, Davis KJ
      Am. J. Pathol., 2003;163(6):2347-70.
    28. Local immunostimulation induced by intravesical administration of autologous interferon-gamma-activated macrophages in patients with superficial bladder cancer.
      Authors: Pages F, Lebel-Binay S, Vieillefond A, Deneux L, Cambillau M, Soubrane O, Debre B, Tardy D, Lemonne JL, Abastado JP, Fridman WH, Thiounn N
      Clin. Exp. Immunol., 2002;127(2):303-9.
      Species: Human
      Sample Type: Urine
    29. Compositional difference in middle ear effusion: mucous versus serous.
      Authors: Chung MH, Choi JY, Lee WS, Kim HN, Yoon JH
      Laryngoscope, 2002;112(1):152-5.
      Species: Human
      Sample Type: middle ear effusion
    30. Hepatocyte growth factor in polymorphonuclear leukocytes is increased in patients with systemic inflammatory response syndrome.
      Authors: Matsushima A, Ogura H, Koh T, Fujita K, Yoshiya K, Sumi Y, Hosotsubo H, Kuwagata Y, Tanaka H, Shimazu T, Sugimoto H
      J Trauma, 2004;56(2):259-64.
      Species: Human
      Sample Type: Plasma
    31. Guiding the vaginal microbicide trials with biomarkers of inflammation.
      Authors: Fichorova RN
      J. Acquir. Immune Defic. Syndr., 2004;37(0):S184-93.
      Species: Human
      Sample Type: cervicovaginal lavage
    32. Central role of complement membrane attack complex in monosodium urate crystal-induced neutrophilic rabbit knee synovitis.
      Authors: Tramontini N, Huber C, Liu-Bryan R, Terkeltaub RA, Kilgore KS
      Arthritis Rheum., 2004;50(8):2633-9.
      Species: Rabbit
      Sample Type: Synovial Fluid
    33. Bronchiectasis, exacerbation indices, and inflammation in chronic obstructive pulmonary disease.
      Authors: Patel IS, Vlahos I, Wilkinson TM, Lloyd-Owen SJ, Donaldson GC, Wilks M, Reznek RH, Wedzicha JA
      Am. J. Respir. Crit. Care Med., 2004;170(4):400-7.
      Species: Human
      Sample Type: Sputum
    34. Embryotoxicity of peritoneal fluid in women with endometriosis. Its relation with cytokines and lymphocyte populations.
      Authors: Gomez-Torres MJ, Acien P, Campos A, Velasco I
      Hum. Reprod., 2002;17(3):777-81.
      Species: Human
      Sample Type: Peritoneal Fluid
    35. Airway antioxidant and inflammatory responses to diesel exhaust exposure in healthy humans.
      Authors: Behndig AF, Mudway IS, Brown JL, Stenfors N, Helleday R, Duggan ST, Wilson SJ, Boman C, Cassee FR, Frew AJ, Kelly FJ, Sandstrom T, Blomberg A
      Eur. Respir. J., 2006;27(2):359-65.
    36. Airway inflammation during stable and acutely exacerbated chronic obstructive pulmonary disease.
      Authors: Fujimoto K, Yasuo M, Urushibata K, Hanaoka M, Koizumi T, Kubo K
      Eur. Respir. J., 2005;25(4):640-6.
      Species: Human
      Sample Type: Sputum
    37. Expression of functional CCR and CXCR chemokine receptors in podocytes.
      Authors: Huber TB, Reinhardt HC, Exner M, Burger JA, Kerjaschki D, Saleem MA, Pavenstadt H
      J. Immunol., 2002;168(12):6244-52.
      Species: Human
      Sample Type: Cell Culture Supernates
    38. Validation of assays for inflammatory mediators in exhaled breath condensate.
      Authors: Bayley DL, Abusriwil H, Ahmad A, Stockley RA
      Eur. Respir. J., 2008;31(5):943-8.
      Species: Human
      Sample Type: Sputum
    39. Cimetidine does not prevent lung injury in newborn premature infants.
      Authors: Cotton RB, Hazinski TA, Morrow JD, Roberts LJ, Zeldin DC, Lindstrom DP, Lappalainen U, Law AB, Steele S
      Pediatr. Res., 2006;59(6):795-800.
      Species: Human
      Sample Type: Tracheal Lavage
    40. The effect of respiratory synctial virus on chemokine release by differentiated airway epithelium.
      Authors: Mellow TE, Murphy PC, Carson JL, Noah TL, Zhang L, Pickles RJ
      Exp. Lung Res., 2004;30(1):43-57.
      Species: Human
      Sample Type: Cell Culture Supernates
    41. Nasal inflammation and personal exposure to fine particles PM2.5 in asthmatic children.
      Authors: Nikasinovic L, Just J, Sahraoui F, Seta N, Grimfeld A, Momas I
      J. Allergy Clin. Immunol., 2006;117(6):1382-8.
      Species: Human
      Sample Type: nasal lavage
    42. Relationship between airway inflammation and the frequency of exacerbations in patients with smoking related COPD.
      Authors: Gompertz S, Bayley DL, Hill SL, Stockley RA
      Thorax, 2001;56(1):36-41.
      Species: Human
      Sample Type: Saliva
    43. Lung injury after ozone exposure is iron dependent.
      Authors: Ghio AJ, Turi JL, Madden MC, Dailey LA, Richards JD, Stonehuerner JG, Morgan DL, Singleton S, Garrick LM, Garrick MD
      Am. J. Physiol. Lung Cell Mol. Physiol., 2007;292(1):L134-43.
    44. Airway neutrophil inflammation in nonasthmatic patients with food allergy.
      Authors: Wallaert B, Gosset P, Lamblin C, Garcia G, Perez T, Tonnel AB
      Allergy, 2002;57(5):405-10.
      Species: Human
      Sample Type: Saliva
    45. Relationship of changes in interleukin-8 levels and granulocyte elastase activity in gingival crevicular fluid to subgingival periodontopathogens following non-surgical periodontal therapy in subjects with chronic periodontitis.
      Authors: Jin LJ, Leung WK, Corbet EF, Soder B
      J. Clin. Periodontol., 2002;29(7):604-14.
      Species: Human
      Sample Type: Gingival Crevicular Fluid (GCF)
    46. Chlamydia pneumoniae immunoglobulin A reactivation and airway inflammation in acute asthma.
      Authors: Wark PA, Johnston SL, Simpson JL, Hensley MJ, Gibson PG
      Eur. Respir. J., 2002;20(4):834-40.
      Species: Human
      Sample Type: Sputum
    47. Interleukin-8 production in tuberculous pleurisy: role of mesothelial cells stimulated by cytokine network involving tumour necrosis factor-alpha and interleukin-1 beta.
      Authors: Park JS, Kim YS, Jee YK, Myong NH, Lee KY
      Scand. J. Immunol., 2003;57(5):463-9.
      Species: Human
      Sample Type: Pleural Effusion
    48. Reduced inspiratory flow attenuates IL-8 release and MAPK activation of lung overstretch.
      Authors: Kotani M, Kotani T, Li Z, Silbajoris R, Piantadosi CA, Huang YC
      Eur. Respir. J., 2004;24(2):238-46.
    49. Normal nasal mucociliary clearance in CF children: evidence against a CFTR-related defect.
      Authors: McShane D, Davies JC, Wodehouse T, Bush A, Geddes D, Alton EW
      Eur. Respir. J., 2004;24(1):95-100.
      Species: Human
      Sample Type: nasal lavage
    50. NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway.
      Authors: Watanabe T, Asano N, Fichtner-Feigl S, Gorelick PL, Tsuji Y, Matsumoto Y, Chiba T, Fuss IJ, Kitani A, Strober W
      J. Clin. Invest., 2010;120(5):1645-62.
    51. Multiplex bead array assays for detection of soluble cytokines: comparisons of sensitivity and quantitative values among kits from multiple manufacturers.
      Authors: Khan SS, Smith MS, Reda D, Suffredini AF, McCoy JP
      Cytometry B Clin Cytom, 2004;61(1):35-9.
      Species: Human
      Sample Type: Serum
    52. Influence of eicosapentaenoic acid, an omega-3 fatty acid, on ultraviolet-B generation of prostaglandin-E2 and proinflammatory cytokines interleukin-1 beta, tumor necrosis factor-alpha, interleukin-6 and interleukin-8 in human skin in vivo.
      Authors: Shahbakhti H, Watson RE, Azurdia RM, Ferreira CZ, Garmyn M, Rhodes LE
      Photochem. Photobiol., 2004;80(2):231-5.
    53. CXCR2 promotes ovarian cancer growth through dysregulated cell cycle, diminished apoptosis, and enhanced angiogenesis.
      Authors: Yang G, Rosen DG, Liu G
      Clin. Cancer Res., 2010;16(15):3875-86.
      Species: Human
      Sample Type: Cell Culture Supernates
    54. Rickettsia rickettsii infection of human macrovascular and microvascular endothelial cells reveals activation of both common and cell type-specific host response mechanisms.
      Authors: Rydkina E, Turpin LC, Sahni SK
      Infect. Immun., 2010;78(6):2599-606.
      Species: Human
      Sample Type: Cell Culture Supernates
    55. Cytokine pattern in blister fluid and sera of patients with pemphigus.
      Authors: Baroni A, Perfetto B, Ruocco E, Greco R, Criscuolo D, Ruocco V
      Dermatology (Basel), 2002;205(2):116-21.
    56. IL-33 promotes the migration and proliferation of circulating fibrocytes from patients with allergen-exacerbated asthma.
      Authors: Bianchetti L, Marini M, Isgro M, Bellini A, Schmidt M, Mattoli S
      Biochem Biophys Res Commun, 2012;426(1):116-21.
      Species: Human
      Sample Type: Cell Culture Supernates
    57. Characterization of innate immune signalling receptors in virus-induced acute asthma.
      Authors: Wood LG, Simpson JL, Wark PA, Powell H, Gibson PG
      Clin. Exp. Allergy, 2011;41(5):640-8.
      Species: Human
      Sample Type: Saliva
    58. Melatonin attenuates the TLR4-mediated inflammatory response through MyD88- and TRIF-dependent signaling pathways in an in vivo model of ovarian cancer.
      Authors: Chuffa L, Fioruci-Fontanelli B, Mendes L, Ferreira Seiva F, Martinez M, Favaro W, Domeniconi R, Pinheiro P, Delazari Dos Santos L, Martinez F
      BMC Cancer, 2015;15(0):34.
      Species: Rat
      Sample Type: Tissue Supernate
    59. Function of interleukin-20 as a proinflammatory molecule in rheumatoid and experimental arthritis.
      Authors: Hsu YH, Li HH, Hsieh MY, Liu MF, Huang KY, Chin LS, Chen PC, Cheng HH, Chang MS
      Arthritis Rheum., 2006;54(9):2722-33.
      Species: Human
      Sample Type: Cell Culture Supernates
    60. Analysis of plasma cytokines and angiogenic factors in patients with pretreated urothelial cancer receiving Pazopanib: the role of circulating interleukin-8 to enhance the prognostic accuracy.
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    62. High levels and inflammatory effects of soluble CXC ligand 16 (CXCL16) in coronary artery disease: down-regulatory effects of statins.
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    65. High expression of ligands for chemokine receptor CXCR2 in alveolar epithelial neoplasia induced by oncogenic kras.
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    67. Protective mucosal immunity elicited by targeted iliac lymph node immunization with a subunit SIV envelope and core vaccine in macaques.
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      Blood, 2007;109(7):2806-14.
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    73. Sensitive plasma protein analysis by microparticle-based proximity ligation assays.
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    75. L5, the most electronegative subfraction of plasma LDL, induces endothelial vascular cell adhesion molecule 1 and CXC chemokines, which mediate mononuclear leukocyte adhesion.
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      Species: Human
      Sample Type: Whole Cells
    140. Angiogenic balance in human melanoma: expression of VEGF, bFGF, IL-8, PDGF and angiostatin in relation to vascular density of xenografts in vivo.
      Authors: Westphal JR, Van't Hullenaar R, Peek R, Willems RW, Crickard K, Crickard U, Askaa J, Clemmensen I, Ruiter DJ, De Waal RM
      Int. J. Cancer, 2000;86(6):768-76.
    141. Relationship between cytokines and the embryotoxicity of hydrosalpingeal fluid.
      Authors: Bedaiwy MA, Falcone T, Goldberg JM, Attaran M, Sharma R, Miller K, Nelson DR, Agarwal A
      J. Assist. Reprod. Genet., 2005;22(4):161-5.
      Species: Human
      Sample Type: Hypersalpingeal fluid (HSF)
    142. Inflammation associated with obesity: relationship with blood and bone marrow endothelial cells.
      Authors: McGuire TR, Brusnahan SK, Bilek LD, Jackson JD, Kessinger MA, Berger AM, Garvin KL, O'Kane BJ, Tuljapurkar SR, Sharp JG
      Obesity (Silver Spring), 2011;19(11):2130-6.
      Species: Human
      Sample Type: Plasma
    143. Secretory IgA induces antigen-independent eosinophil survival and cytokine production without inducing effector functions.
      Authors: Bartemes KR, Cooper KM, Drain KL, Kita H
      J. Allergy Clin. Immunol., 2005;116(4):827-35.
      Species: Human
      Sample Type: Cell Culture Supernates
    144. Chemokine production and chemokine receptor expression by human glioma cells: role of CXCL10 in tumour cell proliferation.
      Authors: Maru SV, Holloway KA, Flynn G, Lancashire CL, Loughlin AJ, Male DK, Romero IA
      J. Neuroimmunol., 2008;199(1):35-45.
    145. Biomarkers for antitumor activity of bevacizumab in gastric cancer models.
      Authors: Yamashita-Kashima Y, Fujimoto-Ouchi K, Yorozu K, Kurasawa M, Yanagisawa M, Yasuno H, Mori K
      BMC Cancer, 2012;12(0):37.
      Species: Human
      Sample Type: Tissue Homogenates
    146. Tissue engineering for full-thickness burns: a dermal substitute from bench to bedside.
      Authors: Kellouche S, Martin C, Korb G, Rezzonico R, Bouard D, Benbunan M, Dubertret L, Soler C, Legrand C, Dosquet C
      Biochem. Biophys. Res. Commun., 2007;363(3):472-8.
      Species: Human
      Sample Type: Cell Culture Supernates
    147. Co-occurrence of IgA antibodies against ethanol metabolites and tissue transglutaminase in alcohol consumers: correlation with proinflammatory cytokines and markers of fibrogenesis.
      Authors: Koivisto H, Hietala J, Anttila P, Niemela O
      Dig. Dis. Sci., 2007;53(2):500-5.
      Species: Human
      Sample Type: Serum
    148. Human Herpesvirus 8 (HHV8) sequentially shapes the NK cell repertoire during the course of asymptomatic infection and Kaposi sarcoma.
      Authors: Dupuy S, Lambert M, Zucman D, Choukem SP, Tognarelli S, Pages C, Lebbe C, Caillat-Zucman S
      PLoS Pathog., 2012;8(1):e1002486.
      Species: Human
      Sample Type: Cell Culture Supernates
    149. Functional genomic analysis in arthritis-affected cartilage: yin-yang regulation of inflammatory mediators by alpha 5 beta 1 and alpha V beta 3 integrins.
      Authors: Attur MG, Dave MN, Clancy RM, Patel IR, Abramson SB, Amin AR
      J. Immunol., 2000;164(5):2684-91.
      Species: Human
      Sample Type: Cell Culture Supernates
    150. Cyclooxygenase-2 inhibitor blocks the production of West Nile virus-induced neuroinflammatory markers in astrocytes.
      Authors: Verma S, Kumar M, Nerurkar VR
      J. Gen. Virol., 2011;92(0):507-15.
      Species: Human
      Sample Type: Cell Culture Supernates
    151. Increased expression of p38 MAPK in human bronchial epithelium after lipopolysaccharide exposure.
      Authors: Roos-Engstrand E, Wallin A, Bucht A, Pourazar J, Sandstrom T, Blomberg A
      Eur. Respir. J., 2005;25(5):797-803.
    152. Relationships between allergic inflammation and nasal airflow in children with seasonal allergic rhinitis.
      Authors: Ciprandi G, Tosca MA, Marseglia GL, Klersy C
      Ann. Allergy Asthma Immunol., 2005;94(2):258-61.
      Species: Human
      Sample Type: nasal lavage
    153. Age-dependent mobilization of circulating endothelial progenitor cells in infants and young children undergoing cardiac surgery with cardiopulmonary bypass.
      Authors: Sun Y, Yi D, Wang Y, Zheng R, Sun G, Wang J, Liu Y, Ren J, Wang Y, Zhang S, Gu C, Pei J
      Cytokine, 2009;47(3):206-13.
      Species: Human
      Sample Type: Plasma
    154. Spontaneous circulation of myeloid-lymphoid-initiating cells and SCID-repopulating cells in sickle cell crisis.
      Authors: Lamming CE, Augustin L, Blackstad M, Lund TC, Hebbel RP, Verfaillie CM
      J. Clin. Invest., 2003;111(6):811-9.
      Species: Human
      Sample Type: Serum
    155. Inflammatory interaction between LIGHT and proteinase-activated receptor-2 in endothelial cells: potential role in atherogenesis.
      Authors: Sandberg WJ, Halvorsen B, Yndestad A, Smith C, Otterdal K, Brosstad FR, Froland SS, Olofsson PS, Damas JK, Gullestad L, Hansson GK, Oie E, Aukrust P
      Circ. Res., 2009;104(1):60-8.
      Species: Human
      Sample Type: Cell Culture Supernates
    156. A randomized trial of recombinant human granulocyte-macrophage colony stimulating factor for patients with acute lung injury.
      Authors: Paine R, Standiford TJ, Dechert RE, Moss M, Martin GS, Rosenberg AL, Thannickal VJ, Burnham EL, Brown MB, Hyzy RC
      Crit. Care Med., 2012;40(1):90-7.
    157. Interleukin-18 is a strong predictor of cardiovascular events in elderly men with the metabolic syndrome: synergistic effect of inflammation and hyperglycemia.
      Authors: Troseid M, Seljeflot I, Hjerkinn EM, Arnesen H
      Diabetes Care, 2009;32(3):486-92.
      Species: Human
      Sample Type: Serum
    158. Skewing of cytotoxic activity and chemokine production, but not of chemokine receptor expression, in human type-1/-2 gamma delta T lymphocytes.
      Authors: D&amp;amp;apos;Ambrosio D
      Eur. J. Immunol., 2002;32(10):2934-43.
      Species: Human
      Sample Type: Cell Culture Supernates
    159. Th1/Th2 cytokines reciprocally regulate in vitro pulmonary angiogenesis via CXC chemokine synthesis.
      Authors: Matsuda A, Fukuda S, Matsumoto K, Saito H
      Am. J. Respir. Cell Mol. Biol., 2007;38(2):168-75.
      Species: Human
      Sample Type: Cell Culture Supernates
    160. A novel IL-1 family cytokine, IL-33, potently activates human eosinophils.
      Authors: Cherry WB, Yoon J, Bartemes KR, Iijima K, Kita H
      J. Allergy Clin. Immunol., 2008;121(6):1484-90.
    161. In vitro and in vivo effects of salbutamol on neutrophil function in acute lung injury.
      Authors: Perkins GD, Nathani N, McAuley DF, Gao F, Thickett DR
      Thorax, 2007;62(1):36-42.
      Species: Human
      Sample Type: BALF
    162. Increased NOS2 predicts poor survival in estrogen receptor-negative breast cancer patients.
      Authors: Glynn SA, Boersma BJ, Dorsey TH, Yi M, Yfantis HG, Ridnour LA, Martin DN, Switzer CH, Hudson RS, Wink DA, Lee DH, Stephens RM, Ambs S
      J. Clin. Invest., 2010;120(11):3843-54.
    163. The influence of anger expression on wound healing.
      Authors: Gouin JP, Kiecolt-Glaser JK, Malarkey WB, Glaser R
      Brain Behav. Immun., 2007;22(5):699-708.
      Species: Human
      Sample Type: Wound Secretion
    164. Urine cytokines profile in renal transplant patients with asymptomatic bacteriuria.
      Authors: Ciszek M, Paczek L, Bartlomiejczyk I, Mucha K
      Transplantation, 2006;81(12):1653-7.
      Species: Human
      Sample Type: Urine
    165. Proliferation, differentiation, and cytokine secretion of human umbilical cord blood-derived mononuclear cells in vitro.
      Authors: Neuhoff S, Moers J, Rieks M, Grunwald T, Jensen A, Dermietzel R, Meier C
      Exp. Hematol., 2007;35(7):1119-31.
      Species: Human
      Sample Type: Cell Culture Supernates
    166. C-reactive protein and vascular cell adhesion molecule-1 as markers of severity in sickle cell disease.
      Authors: Makis AC, Hatzimichael EC, Stebbing J, Bourantas KL
      Arch. Intern. Med., 2006;166(3):366-8.
      Species: Human
      Sample Type: Plasma
    167. The major outer membrane protein of a periodontopathogen induces IFN-beta and IFN-stimulated genes in monocytes via lipid raft and TANK-binding kinase 1/IFN regulatory factor-3.
      Authors: Lee SH, Kim JS, Jun HK
      J. Immunol., 2009;182(9):5823-35.
      Species: Human
      Sample Type: Cell Culture Supernates
    168. Glucocorticoid-induced tumour necrosis factor receptor-related protein-mediated macrophage stimulation may induce cellular adhesion and cytokine expression in rheumatoid arthritis.
      Authors: Bae E, Kim WJ, Kang YM, Suk K, Koh EM, Cha HS, Ahn KS, Huh TL, Lee WH
      Clin. Exp. Immunol., 2007;148(3):410-8.
      Species: Human
      Sample Type: Cell Culture Supernates
    169. Protection against inflammation- and autoantibody-caused fetal loss by the chemokine decoy receptor D6.
      Authors: Martinez de la Torre Y, Buracchi C, Borroni EM, Dupor J, Bonecchi R, Nebuloni M, Pasqualini F, Doni A, Lauri E, Agostinis C, Bulla R, Cook DN, Haribabu B, Meroni P, Rukavina D, Vago L, Tedesco F, Vecchi A, Lira SA, Locati M, Mantovani A
      Proc. Natl. Acad. Sci. U.S.A., 2007;104(7):2319-24.
      Species: Human
      Sample Type: Cell Culture Supernates
    170. IL-8 as antibody therapeutic target in inflammatory diseases: reduction of clinical activity in palmoplantar pustulosis.
      Authors: Skov L, Beurskens FJ, Zachariae CO, Reitamo S, Teeling J, Satijn D, Knudsen KM, Boot EP, Hudson D, Baadsgaard O, Parren PW, van de Winkel JG
      J. Immunol., 2008;181(1):669-79.
      Species: Human
      Sample Type: palmoplantar pustulosis wash fluid
    171. Role of interleukin-8 and growth-regulated oncogene-alpha in the chemotactic migration of all-trans retinoic acid-treated promyelocytic leukemic cells toward alveolar epithelial cells.
      Authors: Tsai WH, Hsu HC, Lin CC, Ho CK, Kou YR
      Crit. Care Med., 2007;35(3):879-85.
    172. In vitro induction of a dendritic cell phenotype in primary human acute myelogenous leukemia (AML) blasts alters the chemokine release profile and increases the levels of T cell chemotactic CCL17 and CCL22.
      Authors: Olsnes AM, Ryningen A, Ersvaer E, Bruserud Ø
      J. Interferon Cytokine Res., 2008;28(5):297-310.
      Species: Human
      Sample Type: Cell Culture Supernates
    173. Different angiogenic activity in pulmonary sarcoidosis and idiopathic pulmonary fibrosis.
      Authors: Antoniou KM, Tzouvelekis A, Alexandrakis MG, Sfiridaki K, Tsiligianni I, Rachiotis G, Tzanakis N, Bouros D, Milic-Emili J, Siafakas NM
      Chest, 2006;130(4):982-8.
      Species: Human
      Sample Type: BALF
    174. p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype.
      Authors: Freund A, Patil CK, Campisi J
      EMBO J., 2011;30(8):1536-48.
      Species: Human
      Sample Type: Cell Culture Supernates
    175. Computed tomographic scan-diagnosed chronic obstructive pulmonary disease-emphysema: eotaxin-1 is associated with bronchodilator response and extent of emphysema.
      Authors: Miller M, Ramsdell J, Friedman PJ, Cho JY, Renvall M, Broide DH
      J. Allergy Clin. Immunol., 2007;120(5):1118-25.
      Species: Human
      Sample Type: BALF
    176. Changes in immune and glial markers in the CSF of patients with Complex Regional Pain Syndrome.
      Authors: Alexander GM, Perreault MJ, Reichenberger ER, Schwartzman RJ
      Brain Behav. Immun., 2006;21(5):668-76.
      Species: Human
      Sample Type: CSF
    177. Effect of interactions between lower airway bacterial and rhinoviral infection in exacerbations of COPD.
      Authors: Wilkinson TM, Hurst JR, Perera WR, Wilks M, Donaldson GC, Wedzicha JA
      Chest, 2006;129(2):317-24.
      Species: Human
      Sample Type: Saliva
    178. IL-33 mediates inflammatory responses in human lung tissue cells.
      Authors: Yagami A, Orihara K, Morita H
      J. Immunol., 2010;185(10):5743-50.
      Species: Human
      Sample Type: Cell Culture Supernates
    179. cAMP/PKA pathway activation in human mesenchymal stem cells in vitro results in robust bone formation in vivo.
      Authors: Siddappa R, Martens A, Doorn J, Leusink A, Olivo C, Licht R, van Rijn L, Gaspar C, Fodde R, Janssen F, van Blitterswijk C, de Boer J
      Proc. Natl. Acad. Sci. U.S.A., 2008;105(20):7281-6.
      Species: Human
      Sample Type: Cell Culture Supernates
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