Human CXCR4 Primer Pair

Human CXCR4 Primer Pair Summary

Specifications

Product Datasheets

Background: CXCR4

CXCR4, also known as fusin or LESTR, is a G protein-coupled receptor (GPCR) member of the CXC subfamily of chemokine receptors. Human CXCR4 is 352 amino acids (aa) in length with a predicted molecular weight of 40 kDa. The mouse and rat proteins share 91% aa sequence identity with the human protein. CXCR4 is the chemokine receptor for CXCL12. CXCR4 is a critical regulator of progenitor and stem cell mobilization and recruitment during development and during hematopoiesis. As such, antagonists of CXCR4 can be used to harvest hematopoietic stem/progenitor cells from bone marrow. Significantly, CXCR4 also acts as a co-receptor for HIV and mediates viral entry and infection of T cells. Studies on multiple tumor types implicate the CXCL12:CXCR4 axis in tumor metastasis and angiogenesis.

Related Research Areas

• Acute Myeloid Leukemia
• B Cell Chemotaxis, Migration, and Adhesion
• B Cell Markers
• Cancer Biomarkers
• Cancer Stem Cell Markers
• Chemokine Receptors
• Chemokines and Receptors in Allergy and Asthma
• Chemokines and Receptors in Angiogenesis
• Chemokines and Receptors in Tfh Cell Differentiation and Function
• Cytokine and Growth Factor Receptors on VSMC
• Endothelial Cell Differentiation Markers
• Endothelial Progenitor and Endothelial Cell Markers
• Endothelial Progenitor Cell Markers
• G Protein-Coupled Receptors in Immune Responses
• G Protein-Coupled Receptors in Nutrition and Appetite
• gamma delta T Cells
• Hematopoietic Stem Cell Markers
• Hepatic Endoderm
• Hepatic Endoderm Cell Markers
• HIF Transcription Factors
• Immune Regulatory Molecules on Endothelial Cells
• Infectious Diseases
• Megakaryocytes
• Microglia Development
• Neural Stem Cell Markers
• Nutrition and Appetite
• Platelet Cytokine and Growth Factor Receptors
• Receptors in the Jak/STAT Pathway
• Regulatory T Cells (Tregs)
• Somite Markers
• T Cell Migration/Adhesion
• Th2 Cells