Human GFR alpha -like Antibody Summary
Accession # Q6UXV0
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Detection of GFR alpha -like in HEK293 Human Cell Line Transfected with Human GFR alpha -like by Flow Cytometry. HEK293 human embryonic kidney cell line transfected with either (A) human GFRa-like (filled histogram) or (B) irrelevant transfectants (open histogram) was stained with Rabbit Anti-Human GFRa-like Monoclonal Antibody (Catalog # MAB9697) followed by Allophycocyanin-conjugated Anti-Rabbit IgG Secondary Antibody (Catalog # F0111). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: GFR alpha-like
GFR alpha -like (GDNF receptor-alpha-like) is a distant member of the GDNFR family of proteins (1). Mature human GFR alpha-like is a 376 amino acid (aa) type I transmembrane protein. It contains a 333 aa extracellular domain, a 20 aa transmembrane domain and a 23 aa cytoplasmic domain. Over the extracellular domain, human GFRAL shares 72% and 71% identity with mouse and rat GFRAL respectively. It is expressed on both fetal and adult hindbrain neurons of the CNS (3), and would appear to function as an anti-apoptotic molecule during neuronal stress. GFRAL is a functional receptor for GDF-15, facilitating weight-loss functions of the protein through c-Ret downstream signaling (2-4). GFRAL and GDF-15 signaling is implicated in diet-based obesity and insulin resistance (2-4).
- Li, Z. et al. (2005) J. Neurochem. 95:361.
- Mullican, S. et al. (2017) Nat. Med 23:1150.
- Yang, L. et al. (2017) Nat. Med 23: 1158.
- Emmerson, P. et al (2017) Nat. Med 23:1215.
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