Human Importin  alpha 2/KPNA2 Antibody

KPNA2 (Karyopherin subunit alpha 2; also SRP1 alpha, importin subunit alpha 2 and RAG1) is a 58-60 kDa member of the importin alpha family of proteins. It is ubiquitously expressed, and found in both nucleus and cytoplasm. KPNA2 functions as a cargo carrier that transports various complexes from cytoplasm into nucleus. For the MRN DNA repair complex, KPNA2 first binds to NBS1, and then to importin beta 1, which mediates movement through the nuclear pore. Human KPNA2 is 529 amino acids (aa) in length. It contains an N-terminal IBB/importin  beta domain (aa 2-60), ten Armadillo repeats that bind "cargo" (aa 71-496) and three intervening NLSs. There is one splice variant that shows a deletion of aa 72-310, coupled to an 11 aa substitution for aa 389-406. Over aa 1-132, human KPNA2 shares 94% aa identity with mouse KPNA2.