Human Leukotriene B4 R1 Alexa Fluor® 350-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: Leukotriene B4 R1

Polymorphonuclear granulocytes secrete the lipid chemotactic mediator Leukotriene B4 (LTB4) in response to inflammatory stimuli (1). Neutrophils, monocytes and lymphocytes respond to LTB4 via specific receptors localized on the cell surface (2-4). The high affinity LTB4 Receptor known as BLT1 is only expressed on leukocytes (5-7) while a second low affinity receptor BLT2 is expressed more ubiquitously (8, 9). The BLT1 and BLT2 are G-protein linked seven-transmembrane spanning receptors that share about 37-45% amino acid identity (8, 9).

Product Datasheets

Related Research Areas

• B Cell Chemotaxis, Migration, and Adhesion
• Bioactive Lipid G Protein-Coupled Receptors
• Bioactive Lipids and Receptors
• Dendritic Cell Activation
• Eicosanoids and Regulators
• G Protein-Coupled Receptors in Immune Responses
• G Protein-Coupled Receptors in Obesity and Related Metabolic Disorders
• Leukotrienes and Receptors
• Neurotransmitter Receptors
• Neurotransmitter Receptors, Transporters, and Ion Channels
• Obesity
• Steroid Hormones and Bioactive Lipids
• T Cell Migration/Adhesion