Human Leukotriene B4 R1 Alexa Fluor® 488-conjugated Antibody Summary
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
Background: Leukotriene B4 R1
Polymorphonuclear granulocytes secrete the lipid chemotactic mediator Leukotriene B4 (LTB4) in response to inflammatory stimuli (1). Neutrophils, monocytes and lymphocytes respond to LTB4 via specific receptors localized on the cell surface (2-4). The high affinity LTB4 Receptor known as BLT1 is only expressed on leukocytes (5-7) while a second low affinity receptor BLT2 is expressed more ubiquitously (8, 9). The BLT1 and BLT2 are G-protein linked seven-transmembrane spanning receptors that share about 37-45% amino acid identity (8, 9).
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- Dasari, V.R. et al. (2000) Immunopharm. 48:157.
- Pettersson, A. et al. (2000) Biochem. Biophys. Res. Comm. 279:520.
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- Kato, K. et al. (2000) J. Exp. Med. 192:413.
- Yokomizo, T. et al. (2000) J. Exp. Med. 192:421.
- Kamohara, M. et al. (2000) J. Biol. Chem. 275:27000.
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