Human/Mouse CX3CR1 Alexa Fluor® 700-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: CX3CR1

CX3CR1 (CX₃C chemokine receptor 1; also fractalkine receptor, GPCR13 and V28) is a 40 kDa (predicted) member of the δ-group of rhodopsin GPCRs. It is expressed on astrocytes, microglia, macrophages, Th1 and Tc1 T cells, NK cells, mouse Gr1^lo monocytes plus smooth muscle and mast cells. CX₃CR1 mediates adhesion to fractalkine, promotes avid binding of integrins to their ligands, and extends the life of monocytes. Mouse CX3CR1 is a 7-transmembrane protein that is 354 amino acids (aa) in length. It contains a 32 aa N-terminal extracellular region that shows no glycosylation, and a 56 aa C-terminal cytoplasmic domain. Over aa 1‑32, 91‑104, 169‑196 and 258‑274 collectively, mouse CX₃CR1 shares 96% and 77% aa identity with rat and human CX₃CR1, respectively.

Product Datasheets

Related Research Areas

• Cancer Stem Cell Markers
• Chemokine Receptors
• Chemokines and Receptors
• Chemokines and Receptors in Allergy and Asthma
• Chemokines and Receptors in Angiogenesis
• Conventional/Classical Dendritic Cells
• Cytokine and Growth Factor Receptors on VSMC
• G Protein-Coupled Receptors in Immune Responses
• Microglia Activation
• Microglia Development
• Microglia Homeostasis
• Microglia Steady-State Markers
• Monocyte Markers
• Mouse Tissue-Resident Macrophage Markers
• Neutrophils
• Platelet Cytokine and Growth Factor Receptors
• Renal Markers
• T Cell Migration/Adhesion
• Uptake of Amyloid beta by Macrophages