Human/Mouse/Rat Total ERK2 DuoSet IC ELISA

Catalog #: DYC1230B-2
2 Citations Datasheet / COA / SDS

Discontinued Product

DYC1230B-2 has been discontinued.
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R&D Systems DuoSet ELISAs
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Product Details
Citations (2)

Human/Mouse/Rat Total ERK2 DuoSet IC ELISA Summary

Assay Range
312.0 - 20,000 pg/mL
Please see the product datasheet

* Provided that the recommended microplates, buffers, diluents, substrates and solutions are used, and the assay is run as summarized in the Assay Procedure provided.

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Preparation and Storage

Background: ERK2

ERK1 and ERK2 (also known as MAPK3 and MAPK1) are 44 and 42 kDa Ser/Thr kinases, respectively. They are part of the Ras-Raf-ERK signal transduction cascade often found downstream of growth factor receptor activation. ERK1 and ERK2 were initially isolated and cloned as kinases activated in response to insulin and NGF. They are expressed in most, if not all, mammalian tissues. Dual threonine and tyrosine phosphorylation activate both ERKs, at Thr202/Tyr204 for human ERK1 and Thr185/Tyr187 for human ERK2.

ERK5, also known as Big Mitogen-activated Protein Kinase 1 (BMK1) and MAPK7, is activated by several mechanisms, including receptor tyrosine kinases, G protein-coupled receptors, and osmotic stress. Like ERK1 and ERK2, ERK5 contains the conserved Thr-Glu-Tyr activation motif in its activation loop. Unlike these ERKs, however, ERK5 contains a unique C-terminal domain that regulates its activation and nuclear translocation.

Long Name:
Extracellular Signal-regulated Kinase 2
Entrez Gene IDs:
5594 (Human); 26413 (Mouse); 116590 (Rat)
Alternate Names:
EC 2.7.11; EC; ERK; ERK2; ERK-2; ERK2MAP kinase isoform p42; ERT1; Extracellular signal-regulated kinase 2; MAP kinase 1; MAP kinase 2; MAPK 1; MAPK1; MAPK2; mitogen-activated protein kinase 1; Mitogen-activated protein kinase 2; p38; p40; p41; p41mapk; p42mapk; p42-MAPK; PRKM1; PRKM1MAPK 2; PRKM2; protein tyrosine kinase ERK2

Citations for Human/Mouse/Rat Total ERK2 DuoSet IC ELISA

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

2 Citations: Showing 1 - 2
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  1. Decreased concentrations of intracellular signaling proteins in colon cancer patients with BRAF mutations
    Authors: DA Olsen, CEB Thomsen, RF Andersen, JS Madsen, A Jakobsen, I Brandslund
    Sci Rep, 2020-11-18;10(1):20113.
    Species: Human
    Sample Types: Tissue Homogenates
  2. In vitro and in vivo pharmacological profile of UFP-512, a novel selective delta-opioid receptor agonist; correlations between desensitization and tolerance.
    Authors: Aguila B, Coulbault L, Boulouard M, Leveille F, Davis A, Toth G, Borsodi A, Balboni G, Salvadori S, Jauzac P, Allouche S
    Br. J. Pharmacol., 2007-11-05;152(8):1312-24.
    Species: Human
    Sample Types: Cell Lysates


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