Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG
View all PER1 Primary Antibodies »

Product Specifications

Immunogen

E. coli-derived recombinant human PER1
Ser159-Thr365
Accession # O15534

Specificity

Detects human PER1 in direct ELISAs.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Applications for Human PER1 Antibody

Application
Recommended Usage

Immunohistochemistry

5-15 µg/mL
Sample: Immersion fixed paraffin-embedded sections of human brain (cortex and hypothalamus)

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Reconstitution

Reconstitute at 0.2 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Calculators

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: PER1

PER1 (Period circadian protein 1; also known as RIGUI) is a 188 kDa member of the PER family of molecules. It apparently influences circadian rhythms by interacting with, and stabilizing, other circadian regulatory proteins. PER1 undergoes extensive phosphorylation that may regulate its intracellular localization. Human PER1 is 1290 amino acids (aa) in length. It contains a bHLH region (aa 122-173), an extended PAS domain (aa 183-463) plus an NLS and NES. Multiple splice forms exist. Two show deletions (aa 741-820 and aa 209-217), while two show aa substitutions: 9 aa for the C-terminal 1005 aa, and 29 aa for the C-terminal 747 amino acids. Over aa 159-365, human PER1 is 96% identical to mouse, rat, and dog PER1.

Long Name

Period Circadian Protein 1

Alternate Names

PERIOD1, RIGUI

Entrez Gene IDs

5187 (Human); 18626 (Mouse)

Gene Symbol

PER1

UniProt

O15534

Additional PER1 Products

Product Documents for Human PER1 Antibody

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

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Product Specific Notices for Human PER1 Antibody

For research use only

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Protocols

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FAQs

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