Human PER1 Antibody

Catalog # Availability Size / Price Qty
AF4565
AF4565-SP
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Human PER1 Antibody Summary

Species Reactivity
Human
Specificity
Detects human PER1 in direct ELISAs.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
E. coli-derived recombinant human PER1
Ser159-Thr365
Accession # O15534
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Immunohistochemistry
5-15 µg/mL
Immersion fixed paraffin-embedded sections of human brain (cortex and hypothalamus)

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

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Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
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Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: PER1

PER1 (Period circadian protein 1; also known as RIGUI) is a 188 kDa member of the PER family of molecules. It apparently influences circadian rhythms by interacting with, and stabilizing, other circadian regulatory proteins. PER1 undergoes extensive phosphorylation that may regulate its intracellular localization. Human PER1 is 1290 amino acids (aa) in length. It contains a bHLH region (aa 122-173), an extended PAS domain (aa 183-463) plus an NLS and NES. Multiple splice forms exist. Two show deletions (aa 741-820 and aa 209-217), while two show aa substitutions: 9 aa for the C-terminal 1005 aa, and 29 aa for the C-terminal 747 amino acids. Over aa 159-365, human PER1 is 96% identical to mouse, rat, and dog PER1.

Long Name
Period Circadian Protein 1
Entrez Gene IDs
5187 (Human); 18626 (Mouse)
Alternate Names
Circadian clock protein PERIOD 1; Circadian pacemaker protein Rigui; hPER1; KIAA0482; PER1; PERhPER; period (Drosophila) homolog 1; period circadian protein homolog 1; period homolog 1 (Drosophila); Period, drosophila, homolog of; PERIOD1; RIGUI; RIGUIMGC88021

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