Human VEGFR2/KDR/Flk‑1 Biotinylated Antibody
Human VEGFR2/KDR/Flk‑1 Biotinylated Antibody Summary
Ala20-Glu764
Accession # AAC16450
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Applications
Human VEGFR2/KDR Sandwich Immunoassay
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
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Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: VEGFR2/KDR/Flk-1
VEGFR2 (KDR/Flk-1), VEGFR1 (Flt-1) and VEGFR3 (Flt-4) belong to the class III subfamily of receptor tyrosine kinases (RTKs). All three receptors contain seven immunoglobulin-like repeats in their extracellular domains and kinase insert domains in their intracellular regions. The expression of VEGFR1, 2, and 3 is almost exclusively restricted to the endothelial cells. These receptors are likely to play essential roles in vasculogenesis and angiogenesis.
VEGFR2 cDNA encodes a 1356 amino acid (aa) residue precursor protein with a 19 aa residue signal peptide. Mature VEGFR2 is composed of a 745 aa residue extracellular domain, a 25 aa residue transmembrane domain and a 567 aa residue cytoplasmic domain. In contrast to VEGFR1 which binds both PlGF and VEGF with high affinity, VEGFR2 binds VEGF but not PlGF with high affinity.
Product Datasheets
Citations for Human VEGFR2/KDR/Flk‑1 Biotinylated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 5
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Characteristics of the specific humoral response in patients with advanced solid tumors after active immunotherapy with a VEGF vaccine, at different antigen doses and using two distinct adjuvants
Authors: J Sánchez Ra, Y Morera Día, M Bequet-Rom, F Hernández-, KH Selman-Hou, A de la Torr, ER Santiesteb, Y Martín Bau, CH Bermúdez B, J de la Torr, JV Gavilondo,, M Ayala Avil
BMC Immunol., 2017;18(1):39.
Species: Human
Sample Types: Serum
Applications: ELISA Development (Detection) -
Specific humoral and cellular immune responses in cancer patients undergoing chronic immunization with a VEGF-based therapeutic vaccine
Authors: Y Morera, J Sánchez, M Bequet-Rom, KH Selman-Hou, A de la Torr, F Hernández-, Y Martín, A Garabito, J Piñero, C Bermúdez, J de la Torr, M Ayala, JV Gavilondo
Vaccine, 2017;0(0):.
Applications: ELISA Development (Detection) -
Vascular endothelial growth factor signals through platelet-derived growth factor receptor beta in meningiomas in vitro.
Br. J. Cancer, 2012;107(10):1702-13.
Species: Human
Sample Types: Cell Lysates
Applications: TaqMan Protein Assay -
Circulating endothelial cells and angiogenic serum factors during neoadjuvant chemotherapy of primary breast cancer.
Authors: Furstenberger G, von Moos R, Lucas R, Thurlimann B, Senn HJ, Hamacher J, Boneberg EM
Br. J. Cancer, 2006;94(4):524-31.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
PEDF derived from glial Muller cells: a possible regulator of retinal angiogenesis.
Authors: Eichler W, Yafai Y, Keller T, Wiedemann P, Reichenbach A
Exp. Cell Res., 2004;299(1):68-78.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot
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