Purified Proteins for Immunotherapy Research and Clinical Manufacturing

Purified Proteins for Immunotherapy Research

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Find Your Immunotherapy Proteins

GMP Cytokines and Growth Factors

GMP Cytokines
and Growth Factors


Most Sensitivity ELISA Kits

Avi-tag and
Amine Labeled Proteins


Fast QuicKit ELISA Kits

Immune Checkpoint
Proteins and Enzymes

Immune Checkpoint

Economical DuoSet ELISA Kits

Cynomolgus and
Rhesus Proteins


Diagnostic IVD ELISA Kits

Custom Protein


Automated ELISA Kits

Bulk Protein


The immune system plays a key role in the recognition and destruction of cancerous cells. Utilizing and enhancing these properties lies at the heart of immunotherapy. Immune checkpoint therapies that target immuno-suppressive proteins such as PD-1, PD-L1 and CTLA4 have led to transformative new treatments for cancer. Purified versions of the proteins are critical for the development of antibodies, drug screening, and quality control assay development. In addition, novel proteins will help define the next generation of Immunotherapy targets.


Good Manufacturing Practices (GMP)-grade Proteins

High-quality raw materials and ancillary reagents are needed for ex vivo cell manufacturing processes. View our GMP protein portfolio.


Biotinylated Proteins: Avi-tag and Amine Biotinylation

R&D Systems offers an expanding line of Avi-tag and amine-labeled biotinylated proteins. QC tested for equivalent bioactivity and lot-to-lot consistency.

biotinylated proteins

Immune Checkpoint Proteins and Enzymes

Popular Immune Checkpoint proteins

PD-1 PD-L1
SIRP alpha CD47
4-1BB 4-1BB Ligand
B7-1 B7-2
LAG-3 Galectin-9
CD40 CD40 Ligand


Next Generation Immune Checkpoint Proteins

Siglecs VSTMs
Butyrophilins VSIGs


Immune Checkpoint Proteins and Enzymes

NEW! Fluorescent-labeled Proteins

Simplify your CAR validation workflow. Bioactive CD19, BCMA, and more conjugated to fluorescent Atto dyes ideal for evaluating CAR expression. Our Fluorescent-labeled proteins are tested using stringent QC standards to ensure consistent labeling while maintaining binding activity and come in a ready to use liquid format eliminating the need for reconstitution. Learn more.


Cynomolgus and Rhesus Proteins

R&D Systems has over 80 cynomolgus and rhesus proteins specifically targeting the Immunotherapy research field.

Cynomolgus and Rhesus Proteins

Custom Protein Development

Utilize our expertise in protein expression, cell culture, protein purification, conjugation, and formulation to create an optimized protein of your choice.

Custom Protein Development