Mouse Adiponectin/Acrp30 Biotinylated Antibody
Mouse Adiponectin/Acrp30 Biotinylated Antibody Summary
Glu18-Asn247
Accession # Q60994
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Adiponectin/Acrp30
Adiponectin, also known as Acrp30, is an adipocyte-derived protein with wide ranging paracrine and endocrine effects on metabolism and inflammation. It promotes adipocyte differentiation, fatty acid catabolism, and insulin sensitivity, and is negatively correlated with obesity, type 2 diabetes, and atherogenesis. In this context, adiponectin is an anti-inflammatory agent, but it exerts pro-inflammatory effects in nonmetabolic disorders such as rheumatoid arthritis and inflammatory bowel disease (1 - 3). Adiponectin interacts with the receptors AdipoR1 and AdipoR2, calreticulin, and Cadherin-13/T-Cadherin, as well as with several growth factors (4 - 7). Mature mouse adiponectin consists of a 66 amino acid (aa) N-terminal collagenous region and a 137 aa C-terminal C1q-like globular domain which can be cleaved by a leukocyte-derived elastase (8 - 10). Mature mouse adiponectin shares 83% and 91% amino acid (aa) sequence identity with human and rat adiponectin, respectively. Adiponectin associates into trimers that may assemble into medium molecular weight (MMW) hexamers and then into >300 kDa high molecular weight (HMW) oligomers (11 - 13). The glycosylation of four hydroxylated lysine residues in the collagenous domain is required for the intracellular formation of HMW complexes (14). The various multimeric forms of adiponectin exhibit distinct tissue specific and gender specific profiles and activities (13, 15).
- Lara-Castro, C. et al. (2007) Curr. Opin. Lipidol. 18:263.
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- Yamauchi, T. et al. (2007) Nat. Med. 13:332.
- Takemura, Y. et al. (2007) J. Clin. Invest. 117:375.
- Hug, C. et al. (2004) Proc. Natl. Acad. Sci. 101:10308.
- Wang, Y. et al. (2005) J. Biol. Chem. 280:18341.
- Scherer, P.E. et al. (1995) J. Biol. Chem. 270:26746.
- Hu, E. et al. (1996) J. Biol. Chem. 271:10697.
- Waki, H. et al. (2005) Endocrinology 146:790.
- Waki, H. et al. (2003) J. Biol. Chem. 278:40352.
- Tsao, T.S. et al. (2003) J. Biol. Chem. 278:50810.
- Wang, Y. et al. (2008) Biochem. J. 409:623.
- Wang, H. et al. (2006) J. Biol. Chem. 281:16391.
- Pajvani, U.B. et al. (2003) J. Biol. Chem. 278:9073.
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