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OR

Mouse GITR/TNFRSF18 Antibody

5 citations
  • Specificity
    Detects mouse GITR/TNFRSF18 in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant human (rh) 4‑1BB, recombinant mouse (rm) CD27, rmCD30, rmEDAR, rmFas, rhGITR, rhHVEM, rmRANK, rhTROY, and rmTNF R1 is observed.
  • Source
    Monoclonal Rat IgG2A Clone # 108619
  • Purification
    Protein A or G purified from hybridoma culture supernatant
  • Immunogen
    Mouse myeloma cell line NS0-derived recombinant mouse GITR/TNFRSF18
    Met1-His153
    Accession # O35714
  • Label
    Unconjugated
Applications
  •  
    Recommended
    Concentration
    Sample
  • Western Blot
    1 µg/mL
    Recombinant Mouse GITR/TNFRSF18 Fc Chimera (Catalog # 524-GR)
    under non-reducing conditions only
  • Flow Cytometry
    2.5 µg/106 cells
    Mouse splenocytes
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
  • Reconstitution
    Reconstitute at 0.5 mg/mL in sterile PBS.
  • Shipping
    The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
  • Stability & Storage
    Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
    • 12 months from date of receipt, -20 to -70 °C as supplied.
    • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
    • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Glucocorticoid Induced TNF Receptor Family Related Gene
GITR (glucocorticoid-induced tumor necrosis factor receptor), also named AITR (activation-inducible TNFreceptor superfamily member) and TNFRSF18, is a 228amino acid typeI transmembrane protein belonging to the TNFreceptor superfamily. The GITR cytoplasmic domain has striking similarity to the cytoplasmic domain of 4-1BB and CD27.
  • Long Name:
    Glucocorticoid Induced TNF Receptor Family Related Gene
  • Entrez Gene IDs:
    8784 (Human); 21936 (Human); 500598 (Rat);
  • Alternate Names:
    Activation-inducible TNFR family receptor; AITRTNF receptor superfamily activation-inducible protein; CD357 antigen; GITR-D; GITRtumor necrosis factor receptor superfamily member 18; Glucocorticoid-induced TNFR-related protein; tumor necrosis factor receptor superfamily, member 18
Related Research Areas
Citations:

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Showing Results 1 - 5 of 5
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Species
Applications
  1. Prevention of cytotoxic T lymphocyte responses to factor IX-expressing hepatocytes by gene transfer-induced regulatory T cells.
    Authors: Dobrzynski E, Fitzgerald JC, Cao O, Mingozzi F, Wang L, Herzog RW
    Proc. Natl. Acad. Sci. U.S.A., 2006;103(12):4592-7.
    Species: Mouse
    Application: Flow Cytometry,
  2. Cutting edge: the natural ligand for glucocorticoid-induced TNF receptor-related protein abrogates regulatory T cell suppression.
    Authors: Ji HB, Liao G, Faubion WA, Abadia-Molina AC, Cozzo C, Laroux FS, Caton A, Terhorst C
    J. Immunol., 2004;172(10):5823-7.
    Species: Mouse
    Application: Flow Cytometry,
  3. Cutting edge: the natural ligand for glucocorticoid-induced TNF receptor-related protein abrogates regulatory T cell suppression.
    Authors: Ji HB, Liao G, Faubion WA, Abadia-Molina AC, Cozzo C, Laroux FS, Caton A, Terhorst C
    J. Immunol., 2004;172(10):5823-7.
  4. An essential role for Scurfin in CD4+CD25+ T regulatory cells.
    Authors: Khattri, Roli, Cox, Tom, Yasayko, Sue-Ann, Ramsdell, Fred
    Nat Immunol, 2003;4(4):337-42.
    Species: Mouse
    Application: Flow Cytometry,
  5. Protection against autoimmunity in nonlymphopenic hosts by CD4+ CD25+ regulatory T cells is antigen-specific and requires IL-10 and TGF-beta.
    Authors: Huang X, Zhu J, Yang Y
    J. Immunol., 2005;175(7):4283-91.
    Species: Mouse
    Application: Flow Cytometry,

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  • Catalog #
    MAB5241

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