Mouse IL-17 Quantikine ELISA Kit

Catalog # Availability Size / Price Qty
PM1700
SM1700
M1700
Mouse IL-17/IL-17A ELISA Standard Curve
2 Images
Product Details
Procedure
Citations (94)
FAQs
Supplemental Products
Reviews (2)

Mouse IL-17 Quantikine ELISA Kit Summary

Assay Type
Solid Phase Sandwich ELISA
Format
96-well strip plate
Assay Length
4.5 hours
Sample Type & Volume Required Per Well
Cell Culture Supernates (50 uL), Serum (50 uL), EDTA Plasma (50 uL), Heparin Plasma (50 uL)
Sensitivity
5 pg/mL
Assay Range
10.9 - 700 pg/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma)
Specificity
Natural and recombinant mouse IL-17
Cross-reactivity
Cross-reactivity observed with 1 or more available related molecules.< 50% cross-species reactivity observed with species tested.
Interference
No significant interference observed with available related molecules.

Product Summary

The Quantikine Mouse IL-17 Immunoassay is a 4.5 hour solid phase ELISA designed to measure mouse IL-17 in cell culture supernates, serum, and plasma. It contains E. coli-expressed recombinant mouse IL-17 and antibodies raised against the recombinant factor. This immunoassay has been shown to quantitate recombinant mouse IL-17 accurately. Results obtained using natural mouse IL-17 showed linear curves that were parallel to the standard curves obtained using the recombinant Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural mouse IL-17.

Precision

Intra-Assay Precision (Precision within an assay) Three samples of known concentration were tested on one plate to assess intra-assay precision
Inter-Assay Precision (Precision between assays) Three samples of known concentration were tested in separate assays to assess inter-assay precision

Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma

Intra-Assay Precision Inter-Assay Precision
Sample 1 2 3 1 2 3
n 20 20 20 20 20 20
Mean 41.9 215 407 43.1 220 411
Standard Deviation 2.1 6.3 8.1 2.2 11.2 18.5
CV% 5 2.9 2 5.1 5.1 4.5

Recovery

The recovery of mouse IL-17 spiked to three levels throughout the range of the assay in various matrices was evaluated.

Sample Type Average % Recovery Range %
Cell Culture Supernates (n=6) 101 92-118
EDTA Plasma (n=3) 107 93-120
Heparin Plasma (n=3) 101 91-123
Serum (n=6) 102 91-108

Linearity

To assess the linearity of the assay, five or more samples containing or spiked with various concentrations of mouse IL-17 in each matrix were diluted with Calibrator Diluent and then assayed.
Mouse IL-17/IL-17A ELISA Linearity

Data Examples

Mouse IL-17/IL-17A ELISA Standard Curve

Product Datasheets

Preparation and Storage

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Background: IL-17/IL-17A

The IL-17 family is comprised of at least six proinflammatory cytokines that share a conserved cysteine-knot structure but diverge at the N-terminus. IL-17 family members are glycoproteins secreted as dimers that induce local cytokine production and recruit granulocytes to sites of inflammation. IL-17 is induced by IL-15 and IL-23, mainly in activated CD4+ T cells distinct from Th1 or Th2 cells. IL-17F is the most homologous to IL-17, but is induced only by IL-23 in activated monocytes. IL-17B binds the IL-17B receptor, but not the IL-17 receptor; it is most homologous with IL-17D, which is expressed by resting CD4+ T cells and CD19+ B cells. IL-17E is mainly produced by Th2 cells and recruits eosinophils to lung tissue. IL-17C has a very restricted expression pattern but has been detected in adult prostate and fetal kidney libraries.

Long Name:
Interleukin 17
Entrez Gene IDs:
3605 (Human); 16171 (Mouse); 301289 (Rat); 449530 (Porcine); 481837 (Canine); 102119976 (Cynomolgus Monkey)
Alternate Names:
CTLA8; CTLA-8; CTLA8cytotoxic T-lymphocyte-associated serine esterase 8; Cytotoxic T-lymphocyte-associated antigen 8; IL17; IL-17; IL17A; IL-17A; IL-17Acytotoxic T-lymphocyte-associated protein 8; IL-17CTLA-8; IL17interleukin-17A; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); interleukin 17A
⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Assay Procedure

Refer to the product for complete assay procedure.

Bring all reagents and samples to room temperature before use. It is recommended that all samples, standards, and controls be assayed in duplicate.
  1.   Prepare all reagents, standard dilutions, and samples as directed in the product insert.
  2.   Remove excess microplate strips from the plate frame, return them to the foil pouch containing the desiccant pack, and reseal.

  3. 50 µL Assay Diluent
  4.   Add 50 µL of Assay Diluent to each well.

  5. 50 µL Standard, Control, or Sample
  6.   Add 50 µL of Standard, Control, or sample to each well. Cover with a plate sealer, and incubate at room temperature for 2 hours.
  7.   Aspirate each well and wash, repeating the process 4 times for a total of 5 washes.

  8. 100 µL Conjugate
  9.   Add 100 µL of Conjugate to each well. Cover with a new plate sealer, and incubate at room temperature for 2 hours.
  10.   Aspirate and wash 5 times.

  11. 100 µL Substrate Solution
  12.   Add 100 µL Substrate Solution to each well. Incubate at room temperature for 30 minutes. PROTECT FROM LIGHT.

  13. 100 µL Stop Solution
  14.   Add 100 µL of Stop Solution to each well. Read at 450 nm within 30 minutes. Set wavelength correction to 540 nm or 570 nm.

Citations for Mouse IL-17 Quantikine ELISA Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

94 Citations: Showing 1 - 10
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  1. Fenoldopam mesylate for treating psoriasis: A new indication for an old drug
    Authors: S Doppalapud, A Jain, W Khan, AJ Domb
    Int J Pharm, 2019;0(0):118726.
    Species: Mouse
    Sample Types: Tissue Homogenates
  2. Control of TLR7-mediated type I IFN signaling in pDCs through CXCR4 engagement-A new target for lupus treatment
    Authors: N Smith, MP Rodero, N Bekaddour, V Bondet, YB Ruiz-Blanc, M Harms, B Mayer, B Badder-Meu, P Quartier, C Bodemer, V Baudouin, Y Dieudonné, F Kirchhoff, E Sanchez Ga, B Charbit, N Leboulange, B Jahrsdörfe, Y Richard, AS Korganow, J Münch, S Nisole, D Duffy, JP Herbeuval
    Sci Adv, 2019;5(7):eaav9019.
    Species: Mouse
    Sample Types: Serum
  3. Modulation of Gut Microbiota Composition by Serotonin Signaling Influences Intestinal Immune Response and Susceptibility to Colitis
    Authors: YH Kwon, H Wang, E Denou, JE Ghia, L Rossi, ME Fontes, SP Bernier, MS Shajib, S Banskota, SM Collins, MG Surette, WI Khan
    Cell Mol Gastroenterol Hepatol, 2019;0(0):.
    Species: Mouse
    Sample Types: Tissue Homogenates
  4. Fasting-Mimicking Diet Modulates Microbiota and Promotes Intestinal Regeneration to Reduce Inflammatory Bowel Disease Pathology
    Authors: P Rangan, I Choi, M Wei, G Navarrete, E Guen, S Brandhorst, N Enyati, G Pasia, D Maesincee, V Ocon, M Abdulridha, VD Longo
    Cell Rep, 2019;26(10):2704-2719.e6.
    Species: Mouse
    Sample Types: Serum
  5. Liver-target nanotechnology facilitates berberine to ameliorate cardio-metabolic diseases
    Authors: HH Guo, CL Feng, WX Zhang, ZG Luo, HJ Zhang, TT Zhang, C Ma, Y Zhan, R Li, S Wu, Z Abliz, C Li, XL Li, XL Ma, LL Wang, WS Zheng, YX Han, JD Jiang
    Nat Commun, 2019;10(1):1981.
    Species: Mouse
    Sample Types: Plasma
  6. Effect of Lactobacillus rhamnosus GG immunopathologic changes in chronic mouse asthma model
    Authors: CT Wu, FH Lin, YT Lee, MS Ku, KH Lue
    J Microbiol Immunol Infect, 2019;0(0):.
    Species: Mouse
    Sample Types: BALF
  7. Bryostatin-1 ameliorated experimental colitis in Il-10-/- Mice by protecting the intestinal barrier and limiting immune dysfunction
    Authors: L Zuo, J Li, S Ge, Y Ge, M Shen, Y Wang, C Zhou, R Wu, J Hu
    J. Cell. Mol. Med., 2019;0(0):.
    Species: Mouse
    Sample Types: Tissue Homogenates
  8. Preventative effects of the partial RANKL peptide MHP1-AcN in a mouse model of imiquimod-induced psoriasis
    Authors: N Ju, M Shimamura, H Hayashi, Y Ikeda, S Yoshida, A Nakamura, R Morishita, H Rakugi, H Nakagami
    Sci Rep, 2019;9(1):15434.
    Species: Mouse
    Sample Types: Serum
  9. Mesenchymal Stem Cells Alleviate Moderate-to-Severe Psoriasis by Reducing the Production of Type I Interferon (IFN-I) by Plasmacytoid Dendritic Cells (pDCs)
    Authors: M Chen, J Peng, Q Xie, N Xiao, X Su, H Mei, Y Lu, J Zhou, Y Dai, S Wang, C Li, G Lin, L Cheng
    Stem Cells Int, 2019;2019(0):6961052.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  10. Immunization with Pseudomonas aeruginosa outer membrane vesicles stimulates protective immunity in mice
    Authors: X Zhang, F Yang, J Zou, W Wu, H Jing, Q Gou, H Li, J Gu, Q Zou, J Zhang
    Vaccine, 2018;36(8):1047-1054.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: ELISA Capture
  11. Juglanin suppresses fibrosis and inflammation response caused by LPS in acute lung injury
    Authors: ZW Dong, YF Yuan
    Int. J. Mol. Med., 2018;41(6):3353-3365.
    Species: Mouse
    Sample Types: Serum
  12. B cell activation in the cecal patches during the development of an experimental colitis model
    Authors: T Watabe, T Nagaishi, N Tsugawa, Y Kojima, N Jose, A Hosoya, M Onizawa, Y Nemoto, S Oshima, T Nakamura, H Karasuyama, T Adachi, M Watanabe
    Biochem. Biophys. Res. Commun., 2018;0(0):.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  13. A Novel Peroxidase Mimics and Ameliorates Alzheimer's Disease-Related Pathology and Cognitive Decline in Mice
    Authors: J Xu, K Wang, Y Yuan, H Li, R Zhang, S Guan, L Wang
    Int J Mol Sci, 2018;19(11):.
    Species: Mouse
    Sample Types: Tissue Homogenates
  14. Estrogen Deficiency Promotes Cerebral Aneurysm Rupture by Upregulation of Th17 Cells and Interleukin-17A Which Downregulates E-Cadherin
    Authors: BL Hoh, K Rojas, L Lin, HZ Fazal, S Hourani, KW Nowicki, MB Schneider, K Hosaka
    J Am Heart Assoc, 2018;7(8):.
    Species: Mouse
    Sample Types: Serum
  15. Fungal immunomodulatory protein-fve could modulate airway remodel through by affect IL17 cytokine
    Authors: YT Lee, CT Wu, HL Sun, JL Ko, KH Lue
    J Microbiol Immunol Infect, 2017;0(0):.
    Species: Mouse
    Sample Types: BALF
  16. In vivo biomarker analysis of intranasally dosed PC945, a novel antifungal triazole, on Aspergillus fumigatus infection in immunocompromised mice
    Authors: G Kimura, T Nakaoki, T Colley, G Rapeport, P Strong, K Ito, Y Kizawa
    Antimicrob. Agents Chemother., 2017;0(0):.
    Species: Mouse
    Sample Types: BALF
  17. RIG-I antiviral signaling drives interleukin-23 production and psoriasis-like skin disease
    Authors: H Zhu, F Lou, Q Yin, Y Gao, Y Sun, J Bai, Z Xu, Z Liu, W Cai, F Ke, L Zhang, H Zhou, H Wang, G Wang, X Chen, H Zhang, Z Wang, F Ginhoux, C Lu, B Su, H Wang
    EMBO Mol Med, 2017;9(5):589-604.
    Species: Mouse
    Sample Types: Tissue Homogenates
  18. Upregulation of SOCS3 in lung CD4+ T cells in a mouse model of chronic PA lung infection and suppression of Th17?mediated neutrophil recruitment in exogenous SOCS3 transfer in vitro
    Authors: FM Ding, RM Liao, YQ Chen, GG Xie, PY Zhang, P Shao, M Zhang
    Mol Med Rep, 2017;0(0):.
    Species: Mouse
    Sample Types: Tissue Homogenates
  19. Regulation of Arthritis Severity by the Acid Sphingomyelinase
    Authors: N Beckmann, KA Becker, S Walter, JU Becker, M Kramer, G Hessler, S Weber, JR Göthert, K Fassbender, E Gulbins, A Carpinteir
    Cell. Physiol. Biochem., 2017;43(4):1.
    Species: Mouse
    Sample Types: Tissue Homogenates
  20. STAT1 Represses Cytokine-Producing Group 2 and Group 3 Innate Lymphoid Cells during Viral Infection
    Authors: MT Stier, K Goleniewsk, JY Cephus, DC Newcomb, TP Sherrill, KL Boyd, MH Bloodworth, ML Moore, K Chen, JK Kolls, RS Peebles
    J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Types: Tissue Homogenates
  21. Placenta?derived mesenchymal stem cells improve airway hyperresponsiveness and inflammation in asthmatic rats by modulating the Th17/Treg balance
    Authors: Y Li, H Li, Y Cao, F Wu, W Ma, Y Wang, S Sun
    Mol Med Rep, 2017;0(0):.
    Species: Rat
    Sample Types: Tissue Homogenates
  22. Protective Efficacy of the Trivalent Pseudomonas aeruginosa Vaccine Candidate PcrV-OprI-Hcp1 in Murine Pneumonia and Burn Models
    Authors: F Yang, J Gu, L Yang, C Gao, H Jing, Y Wang, H Zeng, Q Zou, F Lv, J Zhang
    Sci Rep, 2017;7(1):3957.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  23. Calf Spleen Extractive Injection protects mice against cyclophosphamide-induced hematopoietic injury through G-CSF-mediated JAK2/STAT3 signaling
    Authors: W Lu, D Jia, S An, M Mu, X Qiao, Y Liu, X Li, D Wang
    Sci Rep, 2017;7(1):8402.
    Species: Mouse
    Sample Types: Plasma
  24. CF Lung Infection and Inflammation: IL-17 Pathophysiology and Therapeutic Intervention
    Authors: Daniel Hsu
    Infect Immun, 2016;0(0):.
    Species: Mouse
    Sample Types: BALF
  25. Increased mitochondrial arginine metabolism supports bioenergetics in asthma
    J Clin Invest, 2016;0(0):.
    Species: Mouse
    Sample Types: BALF
  26. Toll-Like Receptor 4 Signaling Pathway Mediates Inhalant Organic Dust-Induced Bone Loss
    PLoS ONE, 2016;11(8):e0158735.
    Species: Mouse
    Sample Types: Serum
  27. IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iTreg cell balance.
    Authors: Basu R, Whitley S, Bhaumik S, Zindl C, Schoeb T, Benveniste E, Pear W, Hatton R, Weaver C
    Nat Immunol, 2015;16(3):286-95.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  28. Critical role for IL-18 in spontaneous lung inflammation caused by autophagy deficiency.
    Authors: Abdel Fattah E, Bhattacharya A, Herron A, Safdar Z, Eissa N
    J Immunol, 2015;194(11):5407-16.
    Species: Mouse
    Sample Types: BALF
  29. Protection against Streptococcus pneumoniae lung infection after nasopharyngeal colonization requires both humoral and cellular immune responses.
    Authors: Wilson R, Cohen J, Jose R, de Vogel C, Baxendale H, Brown J
    Mucosal Immunol, 2015;8(3):627-39.
    Species: Mouse
    Sample Types: Tissue Homogenates
  30. Thalidomide inhibits alternative activation of macrophages in vivo and in vitro: a potential mechanism of anti-asthmatic effect of thalidomide.
    Authors: Lee, Hyun Seu, Kwon, Hyouk-So, Park, Da-Eun, Woo, Yeon Duk, Kim, Hye Youn, Kim, Hang-Rae, Cho, Sang-Heo, Min, Kyung-Up, Kang, Hye-Ryun, Chang, Yoon-Seo
    PLoS ONE, 2015;10(4):e0123094.
    Species: Mouse
    Sample Types: BALF
  31. ASK1 promotes the contact hypersensitivity response through IL-17 production.
    Authors: Mizukami J, Sato T, Camps M, Ji H, Rueckle T, Swinnen D, Tsuboi R, Takeda K, Ichijo H
    Sci Rep, 2014;4(0):4714.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  32. STAT4 deficiency fails to induce lung Th2 or Th17 immunity following primary or secondary respiratory syncytial virus (RSV) challenge but enhances the lung RSV-specific CD8+ T cell immune response to secondary challenge.
    Authors: Dulek D, Newcomb D, Toki S, Goliniewska K, Cephus J, Reiss S, Bates J, Crowe J, Boyd K, Moore M, Zhou W, Peebles R
    J Virol, 2014;88(17):9655-72.
    Species: Mouse
    Sample Types: Tissue Homogenates
  33. IL-7 receptor blockade following T cell depletion promotes long-term allograft survival.
    Authors: Mai H, Boeffard F, Longis J, Danger R, Martinet B, Haspot F, Vanhove B, Brouard S, Soulillou J
    J Clin Invest, 2014;124(4):1723-33.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  34. Prostaglandin E2 negatively regulates the production of inflammatory cytokines/chemokines and IL-17 in visceral leishmaniasis.
    Authors: Saha A, Biswas A, Srivastav S, Mukherjee M, Das P, Ukil A
    J Immunol, 2014;193(5):2330-9.
  35. Allergic airway inflammation decreases lung bacterial burden following acute Klebsiella pneumoniae infection in a neutrophil- and CCL8-dependent manner.
    Authors: Dulek D, Newcomb D, Goleniewska K, Cephus J, Zhou W, Reiss S, Toki S, Ye F, Zaynagetdinov R, Sherrill T, Blackwell T, Moore M, Boyd K, Kolls J, Peebles R
    Infect Immun, 2014;82(9):3723-39.
    Species: Mouse
    Sample Types: Tissue Homogenates
  36. Interleukin 17A promotes pneumococcal clearance by recruiting neutrophils and inducing apoptosis through a p38 mitogen-activated protein kinase-dependent mechanism in acute otitis media.
    Authors: Wang, Wei, Zhou, Aie, Zhang, Xuemei, Xiang, Yun, Huang, Yifei, Wang, Lei, Zhang, Shuai, Liu, Yusi, Yin, Yibing, He, Yujuan
    Infect Immun, 2014;82(6):2368-77.
    Species: Mouse
    Sample Types: MELF
  37. Sirt2 suppresses inflammatory responses in collagen-induced arthritis.
    Authors: Lin J, Sun B, Jiang C, Hong H, Zheng Y
    Biochem Biophys Res Commun, 2013;441(4):897-903.
    Species: Mouse
    Sample Types: Serum
  38. AMPKalpha1 deficiency amplifies proinflammatory myeloid APC activity and CD40 signaling.
    Authors: Carroll K, Viollet B, Suttles J
    J Leukoc Biol, 2013;94(6):1113-21.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  39. Steady-state neutrophil homeostasis is dependent on TLR4/TRIF signaling.
    Authors: Bugl S, Wirths S, Radsak M, Schild H, Stein P, Andre M, Muller M, Malenke E, Wiesner T, Marklin M, Frick J, Handgretinger R, Rammensee H, Kanz L, Kopp H
    Blood, 2013;121(5):723-33.
    Species: Mouse
    Sample Types: Plasma
  40. Targeted inhibition of serotonin type 7 (5-HT7) receptor function modulates immune responses and reduces the severity of intestinal inflammation.
    Authors: Kim, Janice J, Bridle, Byram W, Ghia, Jean-Eri, Wang, Huaqing, Syed, Shahzad, Manocha, Marcus M, Rengasamy, Palanive, Shajib, Mohammad, Wan, Yonghong, Hedlund, Peter B, Khan, Waliul I
    J Immunol, 2013;190(9):4795-804.
    Species: Mouse
    Sample Types: Tissue Homogenates
  41. Staphylococcus aureus sarA regulates inflammation and colonization during central nervous system biofilm formation.
    Authors: Snowden J, Beaver M, Beenken K, Smeltzer M, Horswill A, Kielian T
    PLoS ONE, 2013;8(12):e84089.
    Species: Mouse
    Sample Types: Tissue Homogenates
  42. Salmonella enterica induces joint inflammation and expression of interleukin-17 in draining lymph nodes early after onset of enterocolitis in mice.
    Authors: Noto Llana M, Sarnacki SH, Vazquez MV, Gartner AS, Giacomodonato MN, Cerquetti MC
    Infect. Immun., 2012;80(6):2231-9.
    Species: Mouse
    Sample Types: Tissue Homogenates
  43. The Receptor Slamf1 on the Surface of Myeloid Lineage Cells Controls Susceptibility to Infection by Trypanosoma cruzi.
    Authors: Calderon J, Maganto-Garcia E, Punzon C, Carrion J, Terhorst C, Fresno M
    PLoS Pathog., 2012;8(7):e1002799.
    Species: Mouse
    Sample Types: Serum
  44. Dual functions of prostaglandin D2 in murine contact hypersensitivity via DP and CRTH2.
    Authors: Yamamoto Y, Otani S, Hirai H, Nagata K, Aritake K, Urade Y, Narumiya S, Yokozeki H, Nakamura M, Satoh T
    Am. J. Pathol., 2012;179(1):302-14.
    Species: Mouse
    Sample Types: Tissue Homogenates
  45. The Role of IL-15 in Activating STAT5 and Fine-Tuning IL-17A Production in CD4 T Lymphocytes.
    Authors: Pandiyan P, Yang X, Saravanamuthu S, Zheng L, Ishihara S
    J. Immunol., 2012;189(9):4237-46.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  46. Elevating body temperature enhances hematopoiesis and neutrophil recovery after total body irradiation in an IL-1-, IL-17-, and G-CSF-dependent manner.
    Blood, 2012;120(13):2600-9.
    Species: Mouse
    Sample Types: Tissue Homogenates
  47. The TLR7 ligand 9-benzyl-2-butoxy-8-hydroxy adenine inhibits IL-17 response by eliciting IL-10 and IL-10-inducing cytokines.
    Authors: Vultaggio A, Nencini F, Pratesi S, Maggi L, Guarna A, Annunziato F, Romagnani S, Parronchi P, Maggi E
    J. Immunol., 2011;186(8):4707-15.
    Species: Mouse
    Sample Types: Serum
  48. IL-23-Mediated Epidermal Hyperplasia Is Dependent on IL-6.
    Authors: Lindroos J, Svensson L, Norsgaard H
    J. Invest. Dermatol., 2011;131(5):1110-8.
    Species: Mouse
    Sample Types: Tissue Homogenates
  49. ChemR23 dampens lung inflammation and enhances anti-viral immunity in a mouse model of acute viral pneumonia.
    Authors: Bondue B, Vosters O, de Nadai P, Glineur S, De Henau O, Luangsay S, Van Gool F, Communi D, De Vuyst P, Desmecht D, Parmentier M
    PLoS Pathog., 2011;7(11):e1002358.
    Species: Mouse
    Sample Types: Tissue Homogenates
  50. Reciprocal expression of IL-25 and IL-17A is important for allergic airways hyperreactivity.
    Authors: Barlow JL, Flynn RJ, Ballantyne SJ, McKenzie AN
    Clin. Exp. Allergy, 2011;41(10):1447-55.
    Species: Mouse
    Sample Types: BALF
  51. IL-33-responsive lineage- CD25+ CD44(hi) lymphoid cells mediate innate type 2 immunity and allergic inflammation in the lungs.
    Authors: Bartemes KR, Iijima K, Kobayashi T, Kephart GM, McKenzie AN, Kita H
    J. Immunol., 2011;188(3):1503-13.
    Species: Mouse
    Sample Types: BALF
  52. Serotonin activates dendritic cell function in the context of gut inflammation.
    Authors: Li N, Ghia JE, Wang H, McClemens J, Cote F, Suehiro Y, Mallet J, Khan WI
    Am. J. Pathol., 2011;178(2):662-71.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  53. Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens.
    Authors: DePaolo RW, Abadie V, Tang F
    Nature, 2011;471(7337):220-4.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  54. IL-17-producing invariant NKT cells in lymphoid organs are recent thymic emigrants identified by neuropilin-1 expression.
    Authors: Milpied P, Massot B, Renand A, Diem S, Herbelin A, Leite-de-Moraes M, Rubio MT, Hermine O
    Blood, 2011;118(11):2993-3002.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  55. Role of IL-17A in neutrophil recruitment and hepatic injury after warm ischemia-reperfusion mice.
    Authors: Kono H, Fujii H, Ogiku M, Hosomura N, Amemiya H, Tsuchiya M, Hara M
    J. Immunol., 2011;187(9):4818-25.
    Species: Mouse
    Sample Types: Serum
  56. Morphine disrupts interleukin-23 (IL-23)/IL-17-mediated pulmonary mucosal host defense against Streptococcus pneumoniae infection.
    Authors: Ma J, Wang J, Wan J, Charboneau R, Chang Y, Barke RA, Roy S
    Infect. Immun., 2010;78(2):830-7.
    Species: Mouse
    Sample Types: BALF
  57. TLR4 activation is required for IL-17-induced multiple tissue inflammation and wasting in mice.
    Authors: Tang H, Pang S, Wang M
    J. Immunol., 2010;185(4):2563-9.
    Species: Mouse
    Sample Types: Tissue Homogenates
  58. Prostaglandin I2-IP signaling promotes Th1 differentiation in a mouse model of contact hypersensitivity.
    Authors: Nakajima S, Honda T, Sakata D, Egawa G, Tanizaki H, Otsuka A, Moniaga CS, Watanabe T, Miyachi Y, Narumiya S, Kabashima K
    J. Immunol., 2010;184(10):5595-603.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  59. IL-23 and IL-17A, but not IL-12 and IL-22, are required for optimal skin host defense against Candida albicans.
    Authors: Kagami S, Rizzo HL, Kurtz SE
    J. Immunol., 2010;185(9):5453-62.
    Species: Mouse
    Sample Types: Tissue Homogenates
  60. Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice.
    Authors: Chalaris A, Adam N, Sina C, Rosenstiel P, Lehmann-Koch J, Schirmacher P, Hartmann D, Cichy J, Gavrilova O, Schreiber S, Jostock T, Matthews V, Hasler R, Becker C, Neurath MF, Reiss K, Saftig P, Scheller J, Rose-John S
    J. Exp. Med., 2010;207(8):1617-24.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  61. Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model.
    Authors: Yoshizaki A, Yanaba K, Iwata Y
    J. Immunol., 2010;185(4):2502-15.
    Species: Mouse
    Sample Types: Serum
  62. Enhanced production of IL-17A during zymosan-induced peritonitis in obese mice.
    Authors: Pini M, Fantuzzi G
    J. Leukoc. Biol., 2010;87(1):51-8.
    Species: Mouse
    Sample Types: Peritoneal Lavage Fluid
  63. Antigen-specific Th9 cells exhibit uniqueness in their kinetics of cytokine production and short retention at the inflammatory site.
    Authors: Tan C, Aziz MK, Lovaas JD, Vistica BP, Shi G, Wawrousek EF, Gery I
    J. Immunol., 2010;185(11):6795-801.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  64. A MyD88-dependent early IL-17 production protects mice against airway infection with the obligate intracellular pathogen Chlamydia muridarum.
    Authors: Zhang X, Gao L, Lei L, Zhong Y, Dube P, Berton MT, Arulanandam B, Zhang J, Zhong G
    J. Immunol., 2009;183(2):1291-300.
    Species: Mouse
    Sample Types: BALF
  65. Mouse models of asthma: a comparison between C57BL/6 and BALB/c strains regarding bronchial responsiveness, inflammation, and cytokine production.
    Authors: Gueders MM, Paulissen G, Crahay C, Quesada-Calvo F, Hacha J, Van Hove C, Tournoy K, Louis R, Foidart JM, Noel A, Cataldo DD
    Inflamm. Res., 2009;58(12):845-54.
    Species: Mouse
    Sample Types: BALF
  66. TLR2 deficiency leads to increased Th17 infiltrates in experimental brain abscesses.
    Authors: Nichols JR, Aldrich AL, Mariani MM, Vidlak D, Esen N, Kielian T
    J. Immunol., 2009;182(11):7119-30.
    Species: Mouse
    Sample Types: Tissue Homogenates
  67. Phosphodiesterase 7A inhibitor ASB16165 suppresses proliferation and cytokine production of NKT cells.
    Authors: Goto M, Murakawa M, Kadoshima-Yamaoka K, Tanaka Y, Inoue H, Murafuji H, Hayashi Y, Miura K, Nakatsuka T, Nagahira K, Chamoto K, Fukuda Y, Nishimura T
    Cell. Immunol., 2009;258(2):147-51.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  68. Differential IL-23 requirement for IL-22 and IL-17A production during innate immunity against Salmonella enterica serovar Enteritidis.
    Authors: Siegemund S, Schutze N, Schulz S, Wolk K, Nasilowska K, Straubinger RK, Sabat R, Alber G
    Int. Immunol., 2009;21(5):555-65.
    Species: Mouse
    Sample Types: Serum
  69. Exaggerated IL-17 response to epicutaneous sensitization mediates airway inflammation in the absence of IL-4 and IL-13.
    Authors: He R, Kim HY, Yoon J, Oyoshi MK, MacGinnitie A, Goya S, Freyschmidt EJ, Bryce P, McKenzie AN, Umetsu DT, Oettgen HC, Geha RS
    J. Allergy Clin. Immunol., 2009;124(4):761-70.e1.
    Species: Mouse
    Sample Types: Serum
  70. Inhibition of monocyte-derived inflammatory cytokines by IL-25 occurs via p38 Map kinase-dependent induction of Socs-3.
    Authors: Caruso R, Stolfi C, Sarra M, Rizzo A, Fantini MC, Pallone F, MacDonald TT, Monteleone G
    Blood, 2009;113(15):3512-9.
    Species: Mouse
    Sample Types: Serum
  71. IL-17 receptor signaling is required to control polymicrobial sepsis.
    Authors: Freitas A, Alves-Filho JC, Victoni T, Secher T, Lemos HP, Sonego F, Cunha FQ, Ryffel B
    J. Immunol., 2009;182(12):7846-54.
    Species: Mouse
    Sample Types: Tissue Secretion
  72. Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling.
    Authors: Boniface K, Bak-Jensen KS, Li Y, Blumenschein WM, McGeachy MJ, McClanahan TK, McKenzie BS, Kastelein RA, Cua DJ, de Waal Malefyt R
    J. Exp. Med., 2009;206(3):535-48.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  73. Engagement of the type I interferon receptor on dendritic cells inhibits T helper 17 cell development: role of intracellular osteopontin.
    Authors: Shinohara ML, Kim JH, Garcia VA, Cantor H
    Immunity, 2008;29(1):68-78.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  74. T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance.
    Authors: Pesu M, Watford WT, Wei L, Xu L, Fuss I, Strober W, Andersson J, Shevach EM, Quezado M, Bouladoux N, Roebroek A, Belkaid Y, Creemers J, O'Shea JJ
    Nature, 2008;455(7210):246-50.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  75. An L-selectin ligand distinct from P-selectin glycoprotein ligand-1 is expressed on endothelial cells and promotes neutrophil rolling in inflammation.
    Authors: Shigeta A, Matsumoto M, Tedder TF, Lowe JB, Miyasaka M, Hirata T
    Blood, 2008;112(13):4915-23.
    Species: Mouse
    Sample Types: Serum
  76. Resveratrol inhibits high glucose-induced PI3K/Akt/ERK-dependent interleukin-17 expression in primary mouse cardiac fibroblasts.
    Authors: Venkatachalam K, Mummidi S, Cortez DM, Prabhu SD, Valente AJ, Chandrasekar B
    Am. J. Physiol. Heart Circ. Physiol., 2008;294(5):H2078-87.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  77. Novel immunomodulatory properties of berbamine through selective down-regulation of STAT4 and action of IFN-gamma in experimental autoimmune encephalomyelitis.
    Authors: Ren Y, Lu L, Guo TB, Qiu J, Yang Y, Liu A, Zhang JZ
    J. Immunol., 2008;181(2):1491-8.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  78. Crucial role of the interleukin-6/interleukin-17 cytokine axis in the induction of arthritis by glucose-6-phosphate isomerase.
    Authors: Iwanami K, Matsumoto I, Tanaka-Watanabe Y, Inoue A, Mihara M, Ohsugi Y, Mamura M, Goto D, Ito S, Tsutsumi A, Kishimoto T, Sumida T
    Arthritis Rheum., 2008;58(3):754-63.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  79. Adverse functions of IL-17A in experimental sepsis.
    Authors: Flierl MA, Rittirsch D, Gao H, Hoesel LM, Nadeau BA, Day DE, Zetoune FS, Sarma JV, Huber-Lang MS, Ferrara JL, Ward PA
    FASEB J., 2008;22(7):2198-205.
    Species: Mouse
    Sample Types: Plasma
  80. TLR-2 and IL-17A in chitin-induced macrophage activation and acute inflammation.
    Authors: Da Silva CA, Hartl D, Liu W, Lee CG, Elias JA
    J. Immunol., 2008;181(6):4279-86.
    Species: Mouse
    Sample Types: BALF
  81. Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death.
    Authors: Toscano MA, Bianco GA, Ilarregui JM, Croci DO, Correale J, Hernandez JD, Zwirner NW, Poirier F, Riley EM, Baum LG, Rabinovich GA
    Nat. Immunol., 2007;8(8):825-34.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  82. Functional relevance of the IL-23-IL-17 axis in lungs in vivo.
    Authors: Ivanov S, Bozinovski S, Bossios A, Valadi H, Vlahos R, Malmhall C, Sjostrand M, Kolls JK, Anderson GP, Linden A
    Am. J. Respir. Cell Mol. Biol., 2007;36(4):442-51.
    Species: Mouse
    Sample Types: BALF
  83. IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner.
    Authors: Wei L, Laurence A, Elias KM, O'Shea JJ
    J. Biol. Chem., 2007;282(48):34605-10.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  84. T-bet inhibits both TH2 cell-mediated eosinophil recruitment and TH17 cell-mediated neutrophil recruitment into the airways.
    Authors: Fujiwara M, Hirose K, Kagami S, Takatori H, Wakashin H, Tamachi T, Watanabe N, Saito Y, Iwamoto I, Nakajima H
    J. Allergy Clin. Immunol., 2007;119(3):662-70.
    Species: Mouse
    Sample Types: BALF
  85. The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4.
    Authors: Brustle A, Heink S, Huber M, Rosenplanter C, Stadelmann C, Yu P, Arpaia E, Mak TW, Kamradt T, Lohoff M
    Nat. Immunol., 2007;8(9):958-66.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  86. IL-17 receptor signaling influences virus-induced corneal inflammation.
    Authors: Molesworth-Kenyon SJ, Yin R, Oakes JE, Lausch RN
    J. Leukoc. Biol., 2007;83(2):401-8.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  87. TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology.
    Authors: McGeachy MJ, Bak-Jensen KS, Chen Y, Tato CM, Blumenschein W, McClanahan T, Cua DJ
    Nat. Immunol., 2007;8(12):1390-7.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  88. Intercellular adhesion molecule-1 expression is required on multiple cell types for the development of experimental autoimmune encephalomyelitis.
    Authors: Bullard DC, Hu X, Schoeb TR, Collins RG, Beaudet AL, Barnum SR
    J. Immunol., 2007;178(2):851-7.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  89. A novel polysaccharide of black soybean promotes myelopoiesis and reconstitutes bone marrow after 5-flurouracil- and irradiation-induced myelosuppression.
    Authors: Liao HF, Chen YJ, Yang YC
    Life Sci., 2005;77(4):400-13.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  90. Matrix metalloproteinase-8 deficiency promotes granulocytic allergen-induced airway inflammation.
    Authors: Gueders MM, Balbin M, Rocks N, Foidart JM, Gosset P, Louis R, Shapiro S, Lopez-Otin C, Noel A, Cataldo DD
    J. Immunol., 2005;175(4):2589-97.
    Species: Mouse
    Sample Types: BALF
  91. Endogenous IL-17 as a mediator of neutrophil recruitment caused by endotoxin exposure in mouse airways.
    Authors: Miyamoto M, Prause O, Sjostrand M, Laan M, Lotvall J, Linden A
    J. Immunol., 2003;170(9):4665-72.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  92. IL-17, produced by lymphocytes and neutrophils, is necessary for lipopolysaccharide-induced airway neutrophilia: IL-15 as a possible trigger.
    Authors: Ferretti S, Bonneau O, Dubois GR, Jones CE, Trifilieff A
    J. Immunol., 2003;170(4):2106-12.
    Species: Mouse
    Sample Types: BALF
  93. IL-1-independent role of IL-17 in synovial inflammation and joint destruction during collagen-induced arthritis.
    Authors: Lubberts E, Joosten LA, Oppers B, van den Bersselaar L, Coenen-de Roo CJ, Kolls JK, Schwarzenberger P, van de Loo FA, van den Berg WB
    J. Immunol., 2001;167(2):1004-13.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  94. Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense.
    Authors: Ye P, Rodriguez FH, Kanaly S, Stocking KL, Schurr J, Schwarzenberger P, Oliver P, Huang W, Zhang P, Zhang J, Shellito JE, Bagby GJ, Nelson S, Charrier K, Peschon JJ, Kolls JK
    J. Exp. Med., 2001;194(4):519-27.
    Species: Mouse
    Sample Types: BALF

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