Mouse IL-17 Quantikine ELISA Kit

(77 citations)   
  • Assay Type
    Solid Phase Sandwich ELISA
  • Format
    96-well strip plate
  • Assay Length
    4.5 hours
  • Sample Type & Volume Required Per Well
    Cell Culture Supernates (50 uL), Serum (50 uL), EDTA Plasma (50 uL), Heparin Plasma (50 uL)
  • Sensitivity
    5 pg/mL
  • Assay Range
    10.9 - 700 pg/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma)
  • Specificity
    Natural and recombinant mouse IL-17
  • Cross-reactivity
    Cross-reactivity observed with 1 or more available related molecules.< 50% cross-species reactivity observed with species tested.
  • Interference
    No significant interference observed with available related molecules.
Product Summary
The Quantikine Mouse IL-17 Immunoassay is a 4.5 hour solid phase ELISA designed to measure mouse IL-17 in cell culture supernates, serum, and plasma. It contains E. coli-expressed recombinant mouse IL-17 and antibodies raised against the recombinant factor. This immunoassay has been shown to quantitate recombinant mouse IL-17 accurately. Results obtained using natural mouse IL-17 showed linear curves that were parallel to the standard curves obtained using the recombinant Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural mouse IL-17.

Precision
Intra-Assay Precision (Precision within an assay) Three samples of known concentration were tested on one plate to assess intra-assay precision.
Inter-Assay Precision (Precision between assays) Three samples of known concentration were tested in separate assays to assess inter-assay precision.
Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma
Intra-Assay Precision Inter-Assay Precision
Sample123123
n202020202020
Mean41.921540743.1220411
Standard Deviation2.16.38.12.211.218.5
CV%52.925.15.14.5

Recovery

The recovery of mouse IL-17 spiked to three levels throughout the range of the assay in various matrices was evaluated.

Sample Type Average % Recovery Range %
Cell Culture Supernates (n=6) 101 92-118
EDTA Plasma (n=3) 107 93-120
Heparin Plasma (n=3) 101 91-123
Serum (n=6) 102 91-108
Linearity
To assess the linearity of the assay, five or more samples containing or spiked with various concentrations of mouse IL-17 in each matrix were diluted with Calibrator Diluent and then assayed.
Mouse IL-17 Quantikine ELISA Kit
Preparation and Storage
  • Storage
    Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Background: IL-17/IL-17A
The IL-17 family is comprised of at least six proinflammatory cytokines that share a conserved cysteine-knot structure but diverge at the N-terminus. IL-17 family members are glycoproteins secreted as dimers that induce local cytokine production and recruit granulocytes to sites of inflammation. IL-17 is induced by IL-15 and IL-23, mainly in activated CD4+ T cells distinct from Th1 or Th2 cells. IL-17F is the most homologous to IL-17, but is induced only by IL-23 in activated monocytes. IL-17B binds the IL-17B receptor, but not the IL-17 receptor; it is most homologous with IL-17D, which is expressed by resting CD4+ T cells and CD19+ B cells. IL-17E is mainly produced by Th2 cells and recruits eosinophils to lung tissue. IL-17C has a very restricted expression pattern but has been detected in adult prostate and fetal kidney libraries.
    • Long Name
      Interleukin 17
    • Entrez Gene IDs
      3605 (Human); 16171 (Mouse); 301289 (Rat); 481837 (Canine);
    • Alternate Names
      CTLA-8; CTLA8cytotoxic T-lymphocyte-associated serine esterase 8; Cytotoxic T-lymphocyte-associated antigen 8; IL17; IL-17; IL17A; IL-17A; IL-17Acytotoxic T-lymphocyte-associated protein 8; IL-17CTLA-8; IL17interleukin-17A; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); interleukin 17A;
    Related Research Areas
    Assay Procedure
    Refer to the product for complete assay procedure.

    Bring all reagents and samples to room temperature before use. It is recommended that all samples, standards, and controls be assayed in duplicate.
    1.   Prepare all reagents, standard dilutions, and samples as directed in the product insert.
    2.   Remove excess microplate strips from the plate frame, return them to the foil pouch containing the desiccant pack, and reseal.

    3. 50 µL Assay Diluent
    4.   Add 50 µL of Assay Diluent to each well.

    5. 50 µL Standard, Control, or Sample
    6.   Add 50 µL of Standard, Control, or sample to each well. Cover with a plate sealer, and incubate at room temperature for 2 hours.
    7.   Aspirate each well and wash, repeating the process 4 times for a total of 5 washes.

    8. 100 µL Conjugate
    9.   Add 100 µL of Conjugate to each well. Cover with a new plate sealer, and incubate at room temperature for 2 hours.
    10.   Aspirate and wash 5 times.

    11. 100 µL Substrate Solution
    12.   Add 100 µL Substrate Solution to each well. Incubate at room temperature for 30 minutes. PROTECT FROM LIGHT.

    13. 100 µL Stop Solution
    14.   Add 100 µL of Stop Solution to each well. Read at 450 nm within 30 minutes. Set wavelength correction to 540 nm or 570 nm.
    Citations:

    R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

    77 Citations: Showing 1 - 10
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    Species
    Sample Type
    1. STAT1 Represses Cytokine-Producing Group 2 and Group 3 Innate Lymphoid Cells during Viral Infection
      Authors: MT Stier, K Goleniewsk, JY Cephus, DC Newcomb, TP Sherrill, KL Boyd, MH Bloodworth, ML Moore, K Chen, JK Kolls, RS Peebles
      J. Immunol., 2017;0(0):.
      Species: Mouse
      Sample Type: Tissue Homogenates
    2. Protective Efficacy of the Trivalent Pseudomonas aeruginosa Vaccine Candidate PcrV-OprI-Hcp1 in Murine Pneumonia and Burn Models
      Authors: F Yang, J Gu, L Yang, C Gao, H Jing, Y Wang, H Zeng, Q Zou, F Lv, J Zhang
      Sci Rep, 2017;7(1):3957.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    3. Upregulation of SOCS3 in lung CD4+ T cells in a mouse model of chronic PA lung infection and suppression of Th17?mediated neutrophil recruitment in exogenous SOCS3 transfer in vitro
      Authors: FM Ding, RM Liao, YQ Chen, GG Xie, PY Zhang, P Shao, M Zhang
      Mol Med Rep, 2017;0(0):.
      Species: Mouse
      Sample Type: Tissue Homogenates
    4. Calf Spleen Extractive Injection protects mice against cyclophosphamide-induced hematopoietic injury through G-CSF-mediated JAK2/STAT3 signaling
      Authors: W Lu, D Jia, S An, M Mu, X Qiao, Y Liu, X Li, D Wang
      Sci Rep, 2017;7(1):8402.
      Species: Mouse
      Sample Type: Plasma
    5. Fungal immunomodulatory protein-fve could modulate airway remodel through by affect IL17 cytokine
      Authors: YT Lee, CT Wu, HL Sun, JL Ko, KH Lue
      J Microbiol Immunol Infect, 2017;0(0):.
      Species: Mouse
      Sample Type: BALF
    6. RIG-I antiviral signaling drives interleukin-23 production and psoriasis-like skin disease
      Authors: H Zhu, F Lou, Q Yin, Y Gao, Y Sun, J Bai, Z Xu, Z Liu, W Cai, F Ke, L Zhang, H Zhou, H Wang, G Wang, X Chen, H Zhang, Z Wang, F Ginhoux, C Lu, B Su, H Wang
      EMBO Mol Med, 2017;9(5):589-604.
      Species: Mouse
      Sample Type: Tissue Homogenates
    7. Toll-Like Receptor 4 Signaling Pathway Mediates Inhalant Organic Dust-Induced Bone Loss
      PLoS ONE, 2016;11(8):e0158735.
      Species: Mouse
      Sample Type: Serum
    8. CF Lung Infection and Inflammation: IL-17 Pathophysiology and Therapeutic Intervention
      Authors: Daniel Hsu
      Infect Immun, 2016;0(0):.
      Species: Mouse
      Sample Type: BALF
    9. Increased mitochondrial arginine metabolism supports bioenergetics in asthma
      J Clin Invest, 2016;0(0):.
      Species: Mouse
      Sample Type: BALF
    10. Protection against Streptococcus pneumoniae lung infection after nasopharyngeal colonization requires both humoral and cellular immune responses.
      Authors: Wilson R, Cohen J, Jose R, de Vogel C, Baxendale H, Brown J
      Mucosal Immunol, 2015;8(3):627-39.
      Species: Mouse
      Sample Type: Tissue Homogenates
    11. Critical role for IL-18 in spontaneous lung inflammation caused by autophagy deficiency.
      Authors: Abdel Fattah E, Bhattacharya A, Herron A, Safdar Z, Eissa N
      J Immunol, 2015;194(11):5407-16.
      Species: Mouse
      Sample Type: BALF
    12. IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iTreg cell balance.
      Authors: Basu R, Whitley S, Bhaumik S, Zindl C, Schoeb T, Benveniste E, Pear W, Hatton R, Weaver C
      Nat Immunol, 2015;16(3):286-95.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    13. Thalidomide inhibits alternative activation of macrophages in vivo and in vitro: a potential mechanism of anti-asthmatic effect of thalidomide.
      Authors: Lee, Hyun Seu, Kwon, Hyouk-So, Park, Da-Eun, Woo, Yeon Duk, Kim, Hye Youn, Kim, Hang-Rae, Cho, Sang-Heo, Min, Kyung-Up, Kang, Hye-Ryun, Chang, Yoon-Seo
      PLoS ONE, 2015;10(4):e0123094.
      Species: Mouse
      Sample Type: BALF
    14. Prostaglandin E2 negatively regulates the production of inflammatory cytokines/chemokines and IL-17 in visceral leishmaniasis.
      Authors: Saha A, Biswas A, Srivastav S, Mukherjee M, Das P, Ukil A
      J Immunol, 2014;193(5):2330-9.
    15. STAT4 deficiency fails to induce lung Th2 or Th17 immunity following primary or secondary respiratory syncytial virus (RSV) challenge but enhances the lung RSV-specific CD8+ T cell immune response to secondary challenge.
      Authors: Dulek D, Newcomb D, Toki S, Goliniewska K, Cephus J, Reiss S, Bates J, Crowe J, Boyd K, Moore M, Zhou W, Peebles R
      J Virol, 2014;88(17):9655-72.
      Species: Mouse
      Sample Type: Tissue Homogenates
    16. Interleukin 17A promotes pneumococcal clearance by recruiting neutrophils and inducing apoptosis through a p38 mitogen-activated protein kinase-dependent mechanism in acute otitis media.
      Authors: Wang, Wei, Zhou, Aie, Zhang, Xuemei, Xiang, Yun, Huang, Yifei, Wang, Lei, Zhang, Shuai, Liu, Yusi, Yin, Yibing, He, Yujuan
      Infect Immun, 2014;82(6):2368-77.
      Species: Mouse
      Sample Type: MELF
    17. IL-7 receptor blockade following T cell depletion promotes long-term allograft survival.
      Authors: Mai H, Boeffard F, Longis J, Danger R, Martinet B, Haspot F, Vanhove B, Brouard S, Soulillou J
      J Clin Invest, 2014;124(4):1723-33.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    18. ASK1 promotes the contact hypersensitivity response through IL-17 production.
      Authors: Mizukami J, Sato T, Camps M, Ji H, Rueckle T, Swinnen D, Tsuboi R, Takeda K, Ichijo H
      Sci Rep, 2014;4(0):4714.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    19. Allergic airway inflammation decreases lung bacterial burden following acute Klebsiella pneumoniae infection in a neutrophil- and CCL8-dependent manner.
      Authors: Dulek D, Newcomb D, Goleniewska K, Cephus J, Zhou W, Reiss S, Toki S, Ye F, Zaynagetdinov R, Sherrill T, Blackwell T, Moore M, Boyd K, Kolls J, Peebles R
      Infect Immun, 2014;82(9):3723-39.
      Species: Mouse
      Sample Type: Tissue Homogenates
    20. Targeted inhibition of serotonin type 7 (5-HT7) receptor function modulates immune responses and reduces the severity of intestinal inflammation.
      Authors: Kim, Janice J, Bridle, Byram W, Ghia, Jean-Eri, Wang, Huaqing, Syed, Shahzad, Manocha, Marcus M, Rengasamy, Palanive, Shajib, Mohammad, Wan, Yonghong, Hedlund, Peter B, Khan, Waliul I
      J Immunol, 2013;190(9):4795-804.
      Species: Mouse
      Sample Type: Tissue Homogenates
    21. Steady-state neutrophil homeostasis is dependent on TLR4/TRIF signaling.
      Authors: Bugl S, Wirths S, Radsak M, Schild H, Stein P, Andre M, Muller M, Malenke E, Wiesner T, Marklin M, Frick J, Handgretinger R, Rammensee H, Kanz L, Kopp H
      Blood, 2013;121(5):723-33.
      Species: Mouse
      Sample Type: Plasma
    22. Sirt2 suppresses inflammatory responses in collagen-induced arthritis.
      Authors: Lin J, Sun B, Jiang C, Hong H, Zheng Y
      Biochem Biophys Res Commun, 2013;441(4):897-903.
      Species: Mouse
      Sample Type: Serum
    23. AMPKalpha1 deficiency amplifies proinflammatory myeloid APC activity and CD40 signaling.
      Authors: Carroll K, Viollet B, Suttles J
      J Leukoc Biol, 2013;94(6):1113-21.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    24. Staphylococcus aureus sarA regulates inflammation and colonization during central nervous system biofilm formation.
      Authors: Snowden J, Beaver M, Beenken K, Smeltzer M, Horswill A, Kielian T
      PLoS ONE, 2013;8(12):e84089.
      Species: Mouse
      Sample Type: Tissue Homogenates
    25. Salmonella enterica induces joint inflammation and expression of interleukin-17 in draining lymph nodes early after onset of enterocolitis in mice.
      Authors: Noto Llana M, Sarnacki SH, Vazquez MV, Gartner AS, Giacomodonato MN, Cerquetti MC
      Infect. Immun., 2012;80(6):2231-9.
      Species: Mouse
      Sample Type: Tissue Homogenates
    26. Dual functions of prostaglandin D2 in murine contact hypersensitivity via DP and CRTH2.
      Authors: Yamamoto Y, Otani S, Hirai H, Nagata K, Aritake K, Urade Y, Narumiya S, Yokozeki H, Nakamura M, Satoh T
      Am. J. Pathol., 2012;179(1):302-14.
      Species: Mouse
      Sample Type: Tissue Homogenates
    27. The Role of IL-15 in Activating STAT5 and Fine-Tuning IL-17A Production in CD4 T Lymphocytes.
      Authors: Pandiyan P, Yang X, Saravanamuthu S, Zheng L, Ishihara S
      J. Immunol., 2012;189(9):4237-46.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    28. Elevating body temperature enhances hematopoiesis and neutrophil recovery after total body irradiation in an IL-1-, IL-17-, and G-CSF-dependent manner.
      Blood, 2012;120(13):2600-9.
      Species: Mouse
      Sample Type: Tissue Homogenates
    29. The Receptor Slamf1 on the Surface of Myeloid Lineage Cells Controls Susceptibility to Infection by Trypanosoma cruzi.
      Authors: Calderon J, Maganto-Garcia E, Punzon C, Carrion J, Terhorst C, Fresno M
      PLoS Pathog., 2012;8(7):e1002799.
      Species: Mouse
      Sample Type: Serum
    30. ChemR23 dampens lung inflammation and enhances anti-viral immunity in a mouse model of acute viral pneumonia.
      Authors: Bondue B, Vosters O, de Nadai P, Glineur S, De Henau O, Luangsay S, Van Gool F, Communi D, De Vuyst P, Desmecht D, Parmentier M
      PLoS Pathog., 2011;7(11):e1002358.
      Species: Mouse
      Sample Type: Tissue Homogenates
    31. Serotonin activates dendritic cell function in the context of gut inflammation.
      Authors: Li N, Ghia JE, Wang H, McClemens J, Cote F, Suehiro Y, Mallet J, Khan WI
      Am. J. Pathol., 2011;178(2):662-71.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    32. Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens.
      Authors: DePaolo RW, Abadie V, Tang F
      Nature, 2011;471(7337):220-4.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    33. Role of IL-17A in neutrophil recruitment and hepatic injury after warm ischemia-reperfusion mice.
      Authors: Kono H, Fujii H, Ogiku M, Hosomura N, Amemiya H, Tsuchiya M, Hara M
      J. Immunol., 2011;187(9):4818-25.
      Species: Mouse
      Sample Type: Serum
    34. IL-23-Mediated Epidermal Hyperplasia Is Dependent on IL-6.
      Authors: Lindroos J, Svensson L, Norsgaard H
      J. Invest. Dermatol., 2011;131(5):1110-8.
      Species: Mouse
      Sample Type: Tissue Homogenates
    35. IL-17-producing invariant NKT cells in lymphoid organs are recent thymic emigrants identified by neuropilin-1 expression.
      Authors: Milpied P, Massot B, Renand A, Diem S, Herbelin A, Leite-de-Moraes M, Rubio MT, Hermine O
      Blood, 2011;118(11):2993-3002.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    36. Reciprocal expression of IL-25 and IL-17A is important for allergic airways hyperreactivity.
      Authors: Barlow JL, Flynn RJ, Ballantyne SJ, McKenzie AN
      Clin. Exp. Allergy, 2011;41(10):1447-55.
      Species: Mouse
      Sample Type: BALF
    37. IL-33-responsive lineage- CD25+ CD44(hi) lymphoid cells mediate innate type 2 immunity and allergic inflammation in the lungs.
      Authors: Bartemes KR, Iijima K, Kobayashi T, Kephart GM, McKenzie AN, Kita H
      J. Immunol., 2011;188(3):1503-13.
      Species: Mouse
      Sample Type: BALF
    38. The TLR7 ligand 9-benzyl-2-butoxy-8-hydroxy adenine inhibits IL-17 response by eliciting IL-10 and IL-10-inducing cytokines.
      Authors: Vultaggio A, Nencini F, Pratesi S, Maggi L, Guarna A, Annunziato F, Romagnani S, Parronchi P, Maggi E
      J. Immunol., 2011;186(8):4707-15.
      Species: Mouse
      Sample Type: Serum
    39. Antigen-specific Th9 cells exhibit uniqueness in their kinetics of cytokine production and short retention at the inflammatory site.
      Authors: Tan C, Aziz MK, Lovaas JD, Vistica BP, Shi G, Wawrousek EF, Gery I
      J. Immunol., 2010;185(11):6795-801.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    40. TLR4 activation is required for IL-17-induced multiple tissue inflammation and wasting in mice.
      Authors: Tang H, Pang S, Wang M
      J. Immunol., 2010;185(4):2563-9.
      Species: Mouse
      Sample Type: Tissue Homogenates
    41. Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice.
      Authors: Chalaris A, Adam N, Sina C, Rosenstiel P, Lehmann-Koch J, Schirmacher P, Hartmann D, Cichy J, Gavrilova O, Schreiber S, Jostock T, Matthews V, Hasler R, Becker C, Neurath MF, Reiss K, Saftig P, Scheller J, Rose-John S
      J. Exp. Med., 2010;207(8):1617-24.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    42. Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model.
      Authors: Yoshizaki A, Yanaba K, Iwata Y
      J. Immunol., 2010;185(4):2502-15.
      Species: Mouse
      Sample Type: Serum
    43. Morphine disrupts interleukin-23 (IL-23)/IL-17-mediated pulmonary mucosal host defense against Streptococcus pneumoniae infection.
      Authors: Ma J, Wang J, Wan J, Charboneau R, Chang Y, Barke RA, Roy S
      Infect. Immun., 2010;78(2):830-7.
      Species: Mouse
      Sample Type: BALF
    44. Enhanced production of IL-17A during zymosan-induced peritonitis in obese mice.
      Authors: Pini M, Fantuzzi G
      J. Leukoc. Biol., 2010;87(1):51-8.
      Species: Mouse
      Sample Type: Peritoneal Lavage
    45. IL-23 and IL-17A, but not IL-12 and IL-22, are required for optimal skin host defense against Candida albicans.
      Authors: Kagami S, Rizzo HL, Kurtz SE
      J. Immunol., 2010;185(9):5453-62.
      Species: Mouse
      Sample Type: Tissue Homogenates
    46. Prostaglandin I2-IP signaling promotes Th1 differentiation in a mouse model of contact hypersensitivity.
      Authors: Nakajima S, Honda T, Sakata D, Egawa G, Tanizaki H, Otsuka A, Moniaga CS, Watanabe T, Miyachi Y, Narumiya S, Kabashima K
      J. Immunol., 2010;184(10):5595-603.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    47. Phosphodiesterase 7A inhibitor ASB16165 suppresses proliferation and cytokine production of NKT cells.
      Authors: Goto M, Murakawa M, Kadoshima-Yamaoka K, Tanaka Y, Inoue H, Murafuji H, Hayashi Y, Miura K, Nakatsuka T, Nagahira K, Chamoto K, Fukuda Y, Nishimura T
      Cell. Immunol., 2009;258(2):147-51.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    48. IL-17 receptor signaling is required to control polymicrobial sepsis.
      Authors: Freitas A, Alves-Filho JC, Victoni T, Secher T, Lemos HP, Sonego F, Cunha FQ, Ryffel B
      J. Immunol., 2009;182(12):7846-54.
      Species: Mouse
      Sample Type: Tissue Secretion
    49. A MyD88-dependent early IL-17 production protects mice against airway infection with the obligate intracellular pathogen Chlamydia muridarum.
      Authors: Zhang X, Gao L, Lei L, Zhong Y, Dube P, Berton MT, Arulanandam B, Zhang J, Zhong G
      J. Immunol., 2009;183(2):1291-300.
      Species: Mouse
      Sample Type: BALF
    50. Inhibition of monocyte-derived inflammatory cytokines by IL-25 occurs via p38 Map kinase-dependent induction of Socs-3.
      Authors: Caruso R, Stolfi C, Sarra M, Rizzo A, Fantini MC, Pallone F, MacDonald TT, Monteleone G
      Blood, 2009;113(15):3512-9.
      Species: Mouse
      Sample Type: Serum
    51. Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling.
      Authors: Boniface K, Bak-Jensen KS, Li Y, Blumenschein WM, McGeachy MJ, McClanahan TK, McKenzie BS, Kastelein RA, Cua DJ, de Waal Malefyt R
      J. Exp. Med., 2009;206(3):535-48.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    52. Differential IL-23 requirement for IL-22 and IL-17A production during innate immunity against Salmonella enterica serovar Enteritidis.
      Authors: Siegemund S, Schutze N, Schulz S, Wolk K, Nasilowska K, Straubinger RK, Sabat R, Alber G
      Int. Immunol., 2009;21(5):555-65.
      Species: Mouse
      Sample Type: Serum
    53. Exaggerated IL-17 response to epicutaneous sensitization mediates airway inflammation in the absence of IL-4 and IL-13.
      Authors: He R, Kim HY, Yoon J, Oyoshi MK, MacGinnitie A, Goya S, Freyschmidt EJ, Bryce P, McKenzie AN, Umetsu DT, Oettgen HC, Geha RS
      J. Allergy Clin. Immunol., 2009;124(4):761-70.e1.
      Species: Mouse
      Sample Type: Serum
    54. TLR2 deficiency leads to increased Th17 infiltrates in experimental brain abscesses.
      Authors: Nichols JR, Aldrich AL, Mariani MM, Vidlak D, Esen N, Kielian T
      J. Immunol., 2009;182(11):7119-30.
      Species: Mouse
      Sample Type: Tissue Homogenates
    55. Mouse models of asthma: a comparison between C57BL/6 and BALB/c strains regarding bronchial responsiveness, inflammation, and cytokine production.
      Authors: Gueders MM, Paulissen G, Crahay C, Quesada-Calvo F, Hacha J, Van Hove C, Tournoy K, Louis R, Foidart JM, Noel A, Cataldo DD
      Inflamm. Res., 2009;58(12):845-54.
      Species: Mouse
      Sample Type: BALF
    56. T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance.
      Authors: Pesu M, Watford WT, Wei L, Xu L, Fuss I, Strober W, Andersson J, Shevach EM, Quezado M, Bouladoux N, Roebroek A, Belkaid Y, Creemers J, O'Shea JJ
      Nature, 2008;455(7210):246-50.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    57. Adverse functions of IL-17A in experimental sepsis.
      Authors: Flierl MA, Rittirsch D, Gao H, Hoesel LM, Nadeau BA, Day DE, Zetoune FS, Sarma JV, Huber-Lang MS, Ferrara JL, Ward PA
      FASEB J., 2008;22(7):2198-205.
      Species: Mouse
      Sample Type: Plasma
    58. Crucial role of the interleukin-6/interleukin-17 cytokine axis in the induction of arthritis by glucose-6-phosphate isomerase.
      Authors: Iwanami K, Matsumoto I, Tanaka-Watanabe Y, Inoue A, Mihara M, Ohsugi Y, Mamura M, Goto D, Ito S, Tsutsumi A, Kishimoto T, Sumida T
      Arthritis Rheum., 2008;58(3):754-63.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    59. Engagement of the type I interferon receptor on dendritic cells inhibits T helper 17 cell development: role of intracellular osteopontin.
      Authors: Shinohara ML, Kim JH, Garcia VA, Cantor H
      Immunity, 2008;29(1):68-78.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    60. An L-selectin ligand distinct from P-selectin glycoprotein ligand-1 is expressed on endothelial cells and promotes neutrophil rolling in inflammation.
      Authors: Shigeta A, Matsumoto M, Tedder TF, Lowe JB, Miyasaka M, Hirata T
      Blood, 2008;112(13):4915-23.
      Species: Mouse
      Sample Type: Serum
    61. Resveratrol inhibits high glucose-induced PI3K/Akt/ERK-dependent interleukin-17 expression in primary mouse cardiac fibroblasts.
      Authors: Venkatachalam K, Mummidi S, Cortez DM, Prabhu SD, Valente AJ, Chandrasekar B
      Am. J. Physiol. Heart Circ. Physiol., 2008;294(5):H2078-87.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    62. Novel immunomodulatory properties of berbamine through selective down-regulation of STAT4 and action of IFN-gamma in experimental autoimmune encephalomyelitis.
      Authors: Ren Y, Lu L, Guo TB, Qiu J, Yang Y, Liu A, Zhang JZ
      J. Immunol., 2008;181(2):1491-8.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    63. TLR-2 and IL-17A in chitin-induced macrophage activation and acute inflammation.
      Authors: Da Silva CA, Hartl D, Liu W, Lee CG, Elias JA
      J. Immunol., 2008;181(6):4279-86.
      Species: Mouse
      Sample Type: BALF
    64. Intercellular adhesion molecule-1 expression is required on multiple cell types for the development of experimental autoimmune encephalomyelitis.
      Authors: Bullard DC, Hu X, Schoeb TR, Collins RG, Beaudet AL, Barnum SR
      J. Immunol., 2007;178(2):851-7.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    65. Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death.
      Authors: Toscano MA, Bianco GA, Ilarregui JM, Croci DO, Correale J, Hernandez JD, Zwirner NW, Poirier F, Riley EM, Baum LG, Rabinovich GA
      Nat. Immunol., 2007;8(8):825-34.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    66. The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4.
      Authors: Brustle A, Heink S, Huber M, Rosenplanter C, Stadelmann C, Yu P, Arpaia E, Mak TW, Kamradt T, Lohoff M
      Nat. Immunol., 2007;8(9):958-66.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    67. Functional relevance of the IL-23-IL-17 axis in lungs in vivo.
      Authors: Ivanov S, Bozinovski S, Bossios A, Valadi H, Vlahos R, Malmhall C, Sjostrand M, Kolls JK, Anderson GP, Linden A
      Am. J. Respir. Cell Mol. Biol., 2007;36(4):442-51.
      Species: Mouse
      Sample Type: BALF
    68. T-bet inhibits both TH2 cell-mediated eosinophil recruitment and TH17 cell-mediated neutrophil recruitment into the airways.
      Authors: Fujiwara M, Hirose K, Kagami S, Takatori H, Wakashin H, Tamachi T, Watanabe N, Saito Y, Iwamoto I, Nakajima H
      J. Allergy Clin. Immunol., 2007;119(3):662-70.
      Species: Mouse
      Sample Type: BALF
    69. TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology.
      Authors: McGeachy MJ, Bak-Jensen KS, Chen Y, Tato CM, Blumenschein W, McClanahan T, Cua DJ
      Nat. Immunol., 2007;8(12):1390-7.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    70. IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner.
      Authors: Wei L, Laurence A, Elias KM, O'Shea JJ
      J. Biol. Chem., 2007;282(48):34605-10.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    71. IL-17 receptor signaling influences virus-induced corneal inflammation.
      Authors: Molesworth-Kenyon SJ, Yin R, Oakes JE, Lausch RN
      J. Leukoc. Biol., 2007;83(2):401-8.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    72. A novel polysaccharide of black soybean promotes myelopoiesis and reconstitutes bone marrow after 5-flurouracil- and irradiation-induced myelosuppression.
      Authors: Liao HF, Chen YJ, Yang YC
      Life Sci., 2005;77(4):400-13.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    73. Matrix metalloproteinase-8 deficiency promotes granulocytic allergen-induced airway inflammation.
      Authors: Gueders MM, Balbin M, Rocks N, Foidart JM, Gosset P, Louis R, Shapiro S, Lopez-Otin C, Noel A, Cataldo DD
      J. Immunol., 2005;175(4):2589-97.
      Species: Mouse
      Sample Type: BALF
    74. IL-17, produced by lymphocytes and neutrophils, is necessary for lipopolysaccharide-induced airway neutrophilia: IL-15 as a possible trigger.
      Authors: Ferretti S, Bonneau O, Dubois GR, Jones CE, Trifilieff A
      J. Immunol., 2003;170(4):2106-12.
      Species: Mouse
      Sample Type: BALF
    75. Endogenous IL-17 as a mediator of neutrophil recruitment caused by endotoxin exposure in mouse airways.
      Authors: Miyamoto M, Prause O, Sjostrand M, Laan M, Lotvall J, Linden A
      J. Immunol., 2003;170(9):4665-72.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    76. Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense.
      Authors: Ye P, Rodriguez FH, Kanaly S, Stocking KL, Schurr J, Schwarzenberger P, Oliver P, Huang W, Zhang P, Zhang J, Shellito JE, Bagby GJ, Nelson S, Charrier K, Peschon JJ, Kolls JK
      J. Exp. Med., 2001;194(4):519-27.
      Species: Mouse
      Sample Type: BALF
    77. IL-1-independent role of IL-17 in synovial inflammation and joint destruction during collagen-induced arthritis.
      Authors: Lubberts E, Joosten LA, Oppers B, van den Bersselaar L, Coenen-de Roo CJ, Kolls JK, Schwarzenberger P, van de Loo FA, van den Berg WB
      J. Immunol., 2001;167(2):1004-13.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    Expand to show all 77 Citations
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