Mouse IL-4 Quantikine ELISA Kit

(113 citations)
(2 Reviews)
  
  • Assay Length
    4.5 hours
  • Sample Type & Volume Required Per Well
    Cell Culture Supernates (50 uL), Serum (50 uL)
  • Sensitivity
    2 pg/mL
  • Assay Range
    7.8 - 500 pg/mL (Cell Culture Supernates, Serum)
  • Specificity
    Natural and recombinant mouse IL-4
  • Cross-reactivity
    < 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
  • Interference
    Interference observed with 1 or more available related molecules.
Product Summary
The Quantikine Mouse IL-4 Immunoassay is a 4.5 hour solid phase ELISA designed to measure mouse IL-4 levels in cell culture supernates and serum. It contains E. coli-expressed recombinant mouse IL-4 and antibodies raised against the recombinant factor. This immunoassay has been shown to quantitate the recombinant mouse IL-4 accurately. Results obtained using natural mouse IL-4 showed dose curves that were parallel to the standard curves obtained using the recombinant Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural mouse IL-4.

Precision
Intra-Assay Precision (Precision within an assay) Three samples of known concentration were tested on one plate to assess intra-assay precision.
Inter-Assay Precision (Precision between assays) Three samples of known concentration were tested in separate assays to assess inter-assay precision.
Cell Culture Supernates, Serum
Intra-Assay Precision Inter-Assay Precision
Sample123123
n202020202020
Mean20.158.619920.758.8203
Standard Deviation1.31.88.91.22.710.6
CV%6.53.14.55.84.65.2

Recovery

The recovery of mouse IL-4 spiked to three levels throughout the range of the assay in various matrices was evaluated.

Sample Type Average % Recovery Range %
Cell Culture Supernates (n=8) 95 84-109
Serum (n=7) 95 88-118
Linearity
To assess the linearity of the assay, five or more samples containing and/or spiked with various concentrations of mouse IL-4 in each matrix were diluted with Calibrator Diluent and then assayed.
Mouse IL-4 Quantikine ELISA Kit
Preparation and Storage
  • Storage
    Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Background: IL-4
IL-4 (Interleukin-4) is a cytokine that is primarily expressed by Th2-biased CD4+ T cells, mast cells, basophils, and eosinophils. It promotes cell proliferation, survival, and immunoglobulin class switch to IgG4 and IgE in human B cells, acquisition of the Th2 phenotype by naïve CD4+ T cells, priming and chemotaxis of mast cells, eosinophils, and basophils, and the proliferation and activation of epithelial cells. IL-4 plays a dominant role in the development of allergic inflammation and asthma. The type I receptor for IL-4, which is expressed on hematopoietic cells, is a heterodimer of the ligand binding IL-4 R? and the common ? chain (a shared subunit of the receptors for IL-2, -7, -9, -15, and -21). The type II receptor on nonhematopoietic cells consists of IL-4 R? and IL-13 R?1. The type II receptor also transduces IL-13 mediated signals.
    • Long Name
      Interleukin 4
    • Entrez Gene IDs
      3565 (Human); 16189 (Mouse); 287287 (Rat); 397225 (Porcine); 280824 (Bovine); 403785 (Canine); 574281 (Primate); 100302454 (Rabbit);
    • Alternate Names
      B cell growth factor 1; BCDF; B-cell stimulatory factor 1; BCGF1; BCGF-1; binetrakin; BSF1; BSF-1; IL4; IL-4; IL-4B_cell stimulatory factor 1; interleukin 4; interleukin-4; Lymphocyte stimulatory factor 1; MGC79402; pitrakinra;
    Related Research Areas
    Citations:

    R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

    113 Citations: Showing 1 - 10
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    Species
    Sample Type
    1. Lamtor1 Is Critically Required for CD4(+) T Cell Proliferation and Regulatory T Cell Suppressive Function
      Authors: T Hosokawa, T Kimura, S Nada, T Okuno, D Ito, S Kang, S Nojima, K Yamashita, T Nakatani, Y Hayama, Y Kato, Y Kinehara, M Nishide, N Mikami, S Koyama, H Takamatsu, D Okuzaki, N Ohkura, S Sakaguchi, M Okada, A Kumanogoh
      J. Immunol., 2017;0(0):.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    2. Protective Efficacy of the Trivalent Pseudomonas aeruginosa Vaccine Candidate PcrV-OprI-Hcp1 in Murine Pneumonia and Burn Models
      Authors: F Yang, J Gu, L Yang, C Gao, H Jing, Y Wang, H Zeng, Q Zou, F Lv, J Zhang
      Sci Rep, 2017;7(1):3957.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    3. Fungal immunomodulatory protein-fve could modulate airway remodel through by affect IL17 cytokine
      Authors: YT Lee, CT Wu, HL Sun, JL Ko, KH Lue
      J Microbiol Immunol Infect, 2017;0(0):.
      Species: Mouse
      Sample Type: BALF
    4. Anti-CD20 monoclonal antibody combined with adenovirus vector-mediated IL-10 regulates spleen CD4+/CD8+ T�cells and T-bet/GATA-3 expression in NOD mice
      Authors: A Tang, C Li, Z Chen, T Li
      Mol Med Rep, 2017;0(0):.
      Species: Mouse
      Sample Type: Serum
    5. Effect of a retinoid X receptor partial agonist on airway inflammation and hyperresponsiveness in a murine model of asthma
      Authors: U Fujii, N Miyahara, A Taniguchi, N Oda, D Morichika, E Murakami, H Nakayama, K Waseda, M Kataoka, H Kakuta, M Tanimoto, A Kanehiro
      Respir. Res, 2017;18(1):23.
      Species: Mouse
      Sample Type: BALF
    6. Induction and characterization of anti-tumor endothelium immunity elicited by ValloVax therapeutic cancer vaccine
      Authors: SC Wagner, TE Ichim, V Bogin, WP Min, F Silva, AN Patel, S Kesari
      Oncotarget, 2017;8(17):28595-28613.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    7. Effects of Gintonin-Enriched Fraction in an Atopic Dermatitis Animal Model: Involvement of Autotaxin Regulation
      Authors: BH Lee, HK Kim, M Jang, HJ Kim, SH Choi, SH Hwang, HC Kim, H Rhim, IH Cho, SY Nah
      Biol. Pharm. Bull., 2017;40(7):1063-1070.
      Species: Mouse
      Sample Type: Serum
    8. NLRP3 inflammasome has a protective effect against oxazolone-induced colitis: a possible role in ulcerative colitis
      Sci Rep, 2016;6(0):39075.
      Species: Mouse
      Sample Type: Tissue Homogenates
    9. NLRP3 inflammasome has a protective effect against oxazolone-induced colitis: a possible role in ulcerative colitis
      Sci Rep, 2016;6(0):39075.
      Species: Mouse
      Sample Type: Tissue Homogenates
    10. Absence of the Adaptor Protein PEA-15 Is Associated with Altered Pattern of Th Cytokines Production by Activated CD4+ T Lymphocytes In Vitro, and Defective Red Blood Cell Alloimmune Response In Vivo.
      Authors: Kerbrat S, Vingert B, Junier M, Castellano F, Renault-Mihara F, Dos Reis Tavares S, Surenaud M, Noizat-Pirenne F, Boczkowski J, Guellaen G, Chneiweiss H, Le Gouvello S
      PLoS ONE, 2015;10(8):e0136885.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    11. Propionibacterium acnes Augments Antitumor, Anti-Angiogenesis and Immunomodulatory Effects of Melatonin on Breast Cancer Implanted in Mice.
      Authors: Talib W, Saleh S
      PLoS ONE, 2015;10(4):e0124384.
      Species: Mouse
      Sample Type: Serum
    12. Immunomodulator-based enhancement of anti smallpox immune responses.
      Authors: Martinez O, Miranda E, Ramirez M, Santos S, Rivera C, Vazquez L, Sanchez T, Tremblay R, Rios-Olivares E, Otero M
      PLoS ONE, 2015;10(4):e0123113.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    13. Dendritic cells induce Th2-mediated airway inflammatory responses to house dust mite via DNA-dependent protein kinase.
      Authors: Mishra, Amarjit, Brown, Alexandr, Yao, Xianglan, Yang, Shutong, Park, Sung-Jun, Liu, Chengyu, Dagur, Pradeep, McCoy, J Philip, Keeran, Karen J, Nugent, Gayle Z, Jeffries, Kenneth, Qu, Xuan, Yu, Zu-Xi, Levine, Stewart, Chung, Jay H
      Nat Commun, 2015;6(0):6224.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    14. Determining the role of IL-4 induced neuroinflammation in microglial activity and amyloid-beta using BV2 microglial cells and APP/PS1 transgenic mice.
      Authors: Latta C, Sudduth T, Weekman E, Brothers H, Abner E, Popa G, Mendenhall M, Gonzalez-Oregon F, Braun K, Wilcock D
      J Neuroinflammation, 2015;12(0):41.
    15. IL-33-mediated protection against experimental cerebral malaria is linked to induction of type 2 innate lymphoid cells, M2 macrophages and regulatory T cells.
      Authors: Besnard A, Guabiraba R, Niedbala W, Palomo J, Reverchon F, Shaw T, Couper K, Ryffel B, Liew F
      PLoS Pathog, 2015;11(2):e1004607.
      Species: Mouse
      Sample Type: Serum
    16. G-protein-coupled estrogen receptor agonist suppresses airway inflammation in a mouse model of asthma through IL-10.
      Authors: Itoga M, Konno Y, Moritoki Y, Saito Y, Ito W, Tamaki M, Kobayashi Y, Kayaba H, Kikuchi Y, Chihara J, Takeda M, Ueki S, Hirokawa M
      PLoS ONE, 2015;10(3):e0123210.
      Species: Mouse
      Sample Type: BALF
    17. beta-Arrestin 2 negatively regulates Toll-like receptor 4 (TLR4)-triggered inflammatory signaling via targeting p38 MAPK and interleukin 10.
      Authors: Li H, Hu D, Fan H, Zhang Y, LeSage G, Caudle Y, Stuart C, Liu Z, Yin D
      J Biol Chem, 2014;289(33):23075-85.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    18. Leishmania donovani targets tumor necrosis factor receptor-associated factor (TRAF) 3 for impairing TLR4-mediated host response.
      Authors: Gupta P, Giri J, Srivastav S, Chande A, Mukhopadhyaya R, Das P, Ukil A
      FASEB J, 2014;28(4):1756-68.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    19. Genetic vaccine for respiratory syncytial virus provides protection without disease potentiation.
      Authors: Johnson T, Rangel D, Graham B, Brough D, Gall J
      Mol Ther, 2014;22(1):196-205.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    20. Deficiency of RAMP1 attenuates antigen-induced airway hyperresponsiveness in mice.
      Authors: Li, Manyu, Wetzel-Strong, Sarah E, Hua, Xiaoyang, Tilley, Stephen, Oswald, Erin, Krummel, Matthew, Caron, Kathleen
      PLoS ONE, 2014;9(7):e102356.
      Species: Mouse
      Sample Type: BALF
    21. Improvement of spinal non-viral IL-10 gene delivery by D-mannose as a transgene adjuvant to control chronic neuropathic pain.
      Authors: Dengler E, Alberti L, Bowman B, Kerwin A, Wilkerson J, Moezzi D, Limanovich E, Wallace J, Milligan E
      J Neuroinflammation, 2014;11(0):92.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    22. Axl receptor blockade ameliorates pulmonary pathology resulting from primary viral infection and viral exacerbation of asthma.
      Authors: Shibata T, Habiel D, Coelho A, Kunkel S, Lukacs N, Hogaboam C
      J Immunol, 2014;192(8):3569-81.
      Species: Mouse
      Sample Type: Tissue Homogenates
    23. Enhanced immunogenicity of a tricomponent mannan tetanus toxoid conjugate vaccine targeted to dendritic cells via Dectin-1 by incorporating beta-glucan.
      Authors: Lipinski T, Fitieh A, St Pierre J, Ostergaard H, Bundle D, Touret N
      J Immunol, 2013;190(8):4116-28.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    24. Lyn mitigates mouse airway remodeling by downregulating the TGF-beta3 isoform in house dust mite models.
      Authors: Li G, Fox J, Liu Z, Liu J, Gao G, Jin Y, Gao H, Wu M
      J Immunol, 2013;191(11):5359-70.
      Species: Mouse
      Sample Type: BALF
    25. Spironolactone attenuates bleomycin-induced pulmonary injury partially via modulating mononuclear phagocyte phenotype switching in circulating and alveolar compartments.
      Authors: Ji W, Ma Y, Zhou X, Zhang Y, Lu R, Guo Z, Sun H, Hu D, Yang G, Li Y, Wei L
      PLoS ONE, 2013;8(11):e81090.
      Species: Mouse
      Sample Type: BALF
    26. Induction of the specific allergic immune response is independent of proteases from the fungus Alternaria alternata.
      Authors: Denis O, Vincent M, Havaux X, De Prins S, Treutens G, Huygen K
      Eur J Immunol, 2013;43(4):907-17.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    27. Targeted inhibition of serotonin type 7 (5-HT7) receptor function modulates immune responses and reduces the severity of intestinal inflammation.
      Authors: Kim, Janice J, Bridle, Byram W, Ghia, Jean-Eri, Wang, Huaqing, Syed, Shahzad, Manocha, Marcus M, Rengasamy, Palanive, Shajib, Mohammad, Wan, Yonghong, Hedlund, Peter B, Khan, Waliul I
      J Immunol, 2013;190(9):4795-804.
      Species: Mouse
      Sample Type: Tissue Homogenates
    28. Interleukin-33 and alveolar macrophages contribute to the mechanisms underlying the exacerbation of IgE-mediated airway inflammation and remodelling in mice.
      Authors: Mizutani N, Nabe T, Yoshino S
      Immunology, 2013;139(2):205-18.
      Species: Mouse
      Sample Type: Tissue Homogenates
    29. Monocyte-derived dendritic cell recruitment and allergic T(H)2 responses after exposure to diesel particles are CCR2 dependent.
      Authors: Provoost S, Maes T, Joos GF, Tournoy KG
      J. Allergy Clin. Immunol., 2012;129(2):483-91.
      Species: Mouse
      Sample Type: BALF
    30. The Receptor Slamf1 on the Surface of Myeloid Lineage Cells Controls Susceptibility to Infection by Trypanosoma cruzi.
      Authors: Calderon J, Maganto-Garcia E, Punzon C, Carrion J, Terhorst C, Fresno M
      PLoS Pathog., 2012;8(7):e1002799.
      Species: Mouse
      Sample Type: Serum
    31. TLR-mediated distinct IFN-gamma/IL-10 pattern induces protective immunity against murine visceral leishmaniasis.
      Eur. J. Immunol., 2012;42(8):2087-99.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    32. Dual functions of prostaglandin D2 in murine contact hypersensitivity via DP and CRTH2.
      Authors: Yamamoto Y, Otani S, Hirai H, Nagata K, Aritake K, Urade Y, Narumiya S, Yokozeki H, Nakamura M, Satoh T
      Am. J. Pathol., 2012;179(1):302-14.
      Species: Mouse
      Sample Type: Tissue Homogenates
    33. IL-33-activated dendritic cells are critical for allergic airway inflammation.
      Authors: Besnard AG, Togbe D, Guillou N, Erard F, Quesniaux V, Ryffel B
      Eur. J. Immunol., 2011;41(6):1675-86.
      Species: Mouse
      Sample Type: BALF
    34. Differential host determinants contribute to the pathogenesis of 2009 pandemic H1N1 and human H5N1 influenza A viruses in experimental mouse models.
      Authors: Otte A, Sauter M, Alleva L, Baumgarte S, Klingel K, Gabriel G
      Am. J. Pathol., 2011;179(1):230-9.
      Species: Mouse
      Sample Type: Serum
    35. IL-33-responsive lineage- CD25+ CD44(hi) lymphoid cells mediate innate type 2 immunity and allergic inflammation in the lungs.
      Authors: Bartemes KR, Iijima K, Kobayashi T, Kephart GM, McKenzie AN, Kita H
      J. Immunol., 2011;188(3):1503-13.
      Species: Mouse
      Sample Type: BALF
    36. Serotonin activates dendritic cell function in the context of gut inflammation.
      Authors: Li N, Ghia JE, Wang H, McClemens J, Cote F, Suehiro Y, Mallet J, Khan WI
      Am. J. Pathol., 2011;178(2):662-71.
      Species: Mouse
      Sample Type: Tissue Homogenates
    37. The interaction between IL-18 and IL-18 receptor limits the magnitude of protective immunity and enhances pathogenic responses following infection with intracellular bacteria.
      Authors: Ghose P, Ali AQ, Fang R, Forbes D, Ballard B, Ismail N
      J. Immunol., 2011;187(3):1333-46.
      Species: Mouse
      Sample Type: Serum
    38. Control of mouse graft-versus-host disease following allogeneic bone marrow transplantation by blocking the CD28/B7 signaling pathway with lentiviral vector-mediated RNA interference.
      Authors: Sang W, Zhou C, Cheng N, Li Z, Zeng L, Xu K
      Immunol. Lett., 2011;136(2):194-202.
      Species: Mouse
      Sample Type: Plasma
    39. Over-expression of the LTC4 synthase gene in mice reproduces human aspirin-induced asthma.
      Authors: Hirata H, Arima M, Fukushima Y, Honda K, Sugiyama K, Tokuhisa T, Fukuda T
      Clin. Exp. Allergy, 2011;41(8):1133-42.
      Species: Mouse
      Sample Type: BALF
    40. Tumors Suppress In Situ Proliferation of Cytotoxic T Cells by Promoting Differentiation of Gr-1+ Conventional Dendritic Cells through IL-6.
      Authors: Diao J, Zhao J, Winter E
      J. Immunol., 2011;186(9):5058-67.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    41. Epithelial reticulon 4B (Nogo-B) is an endogenous regulator of Th2-driven lung inflammation.
      Authors: Wright PL, Yu J, Di YP
      J. Exp. Med., 2010;207(12):2595-607.
      Species: Mouse
      Sample Type: BALF
    42. Microbial exposure early in life regulates airway inflammation in mice after infection with Streptococcus pneumoniae with enhancement of local resistance.
      Authors: Yasuda Y, Matsumura Y, Kasahara K, Ouji N, Sugiura S, Mikasa K, Kita E
      Am. J. Physiol. Lung Cell Mol. Physiol., 2010;298(1):L67-78.
      Species: Mouse
      Sample Type: BALF
    43. Proinflammatory clearance of apoptotic neutrophils induces an IL-12(low)IL-10(high) regulatory phenotype in macrophages.
      Authors: Filardy AA, Pires DR, Nunes MP, Takiya CM, Freire-de-Lima CG, Ribeiro-Gomes FL, DosReis GA
      J. Immunol., 2010;185(4):2044-50.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    44. Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model.
      Authors: Yoshizaki A, Yanaba K, Iwata Y
      J. Immunol., 2010;185(4):2502-15.
      Species: Mouse
      Sample Type: Serum
    45. Ovalbumin-induced plasma interleukin-4 levels are reduced in ceramide kinase-deficient DO11.10 RAG1-/- mice.
      Authors: Niwa S, Urtz N, Baumruker T, Billich A, Bornancin F
      Lipids Health Dis, 2010;9(0):1.
      Species: Mouse
      Sample Type: Serum
    46. Lovastatin inhibits antigen-induced airway eosinophilia without affecting the production of inflammatory mediators in mice.
      Authors: Chiba Y, Sato S, Misawa M
      Inflamm. Res., 2009;0(0):.
      Species: Mouse
      Sample Type: BALF
    47. Complement C3a regulates late asthmatic response and airway hyperresponsiveness in mice.
      Authors: Mizutani N, Nabe T, Yoshino S
      J. Immunol., 2009;183(6):4039-46.
      Species: Mouse
      Sample Type: BALF
    48. Mouse models of asthma: a comparison between C57BL/6 and BALB/c strains regarding bronchial responsiveness, inflammation, and cytokine production.
      Authors: Gueders MM, Paulissen G, Crahay C, Quesada-Calvo F, Hacha J, Van Hove C, Tournoy K, Louis R, Foidart JM, Noel A, Cataldo DD
      Inflamm. Res., 2009;58(12):845-54.
      Species: Mouse
      Sample Type: BALF
    49. Macrophage migration inhibitory factor homologs of anisakis simplex suppress Th2 response in allergic airway inflammation model via CD4+CD25+Foxp3+ T cell recruitment.
      Authors: Park SK, Cho MK, Park HK, Lee KH, Lee SJ, Choi SH, Ock MS, Jeong HJ, Lee MH, Yu HS
      J. Immunol., 2009;182(11):6907-14.
      Species: Mouse
      Sample Type: BALF
    50. Intranasal challenge with increasing ovalbumin doses differently affects airway hyperresponsiveness and inflammatory cell accumulation in mouse model of asthma.
      Authors: Bosnjak B, Ivetic Tkalcevic V, Duric K, Belamaric D, Cuzic S, Ferencic Z, Brajsa K, Glojnaric I, Antolovic R, Hrvacic B
      Inflamm. Res., 2009;58(11):773-81.
      Species: Mouse
      Sample Type: BALF
    51. A MyD88-dependent early IL-17 production protects mice against airway infection with the obligate intracellular pathogen Chlamydia muridarum.
      Authors: Zhang X, Gao L, Lei L, Zhong Y, Dube P, Berton MT, Arulanandam B, Zhang J, Zhong G
      J. Immunol., 2009;183(2):1291-300.
      Species: Mouse
      Sample Type: BALF
    52. Celastrol suppresses allergen-induced airway inflammation in a mouse allergic asthma model.
      Authors: Kim DY, Park JW, Jeoung D, Ro JY
      Eur. J. Pharmacol., 2009;612(1):98-105.
      Species: Mouse
      Sample Type: BALF
    53. The adjuvancy of OX40 ligand (CD252) on an HIV-1 canarypox vaccine.
      Authors: Liu J, Ngai N, Stone GW, Yue FY, Ostrowski MA
      Vaccine, 2009;27(37):5077-84.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    54. Effects of a leukotriene B4 receptor antagonist on bleomycin-induced pulmonary fibrosis.
      Authors: Izumo T, Kondo M, Nagai A
      Eur. Respir. J., 2009;34(6):1444-51.
      Species: Mouse
      Sample Type: BALF
    55. TLR9 agonist, but not TLR7/8, functions as an adjuvant to diminish FI-RSV vaccine-enhanced disease, while either agonist used as therapy during primary RSV infection increases disease severity.
      Authors: Johnson TR, Rao S, Seder RA, Chen M, Graham BS
      Vaccine, 2009;27(23):3045-52.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    56. A severe deficiency of coagulation factor VIIa results in attenuation of the asthmatic response in mice.
      Authors: Shinagawa K, Ploplis VA, Castellino FJ
      Am. J. Physiol. Lung Cell Mol. Physiol., 2009;296(5):L763-70.
      Species: Mouse
      Sample Type: BALF
    57. NOD2-deficient mice have impaired resistance to Mycobacterium tuberculosis infection through defective innate and adaptive immunity.
      Authors: Divangahi M, Mostowy S, Coulombe F, Kozak R, Guillot L, Veyrier F, Kobayashi KS, Flavell RA, Gros P, Behr MA
      J. Immunol., 2008;181(10):7157-65.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    58. The novel inosine analogue, INO-2002, protects against diabetes development in multiple low-dose streptozotocin and non-obese diabetic mouse models of type I diabetes.
      Authors: Mabley JG, Pacher P, Murthy KG, Williams W, Southan GJ, Salzman AL, Szabo C
      J. Endocrinol., 2008;198(3):581-9.
      Species: Mouse
      Sample Type: Tissue Homogenates
    59. GS143, an IkappaB ubiquitination inhibitor, inhibits allergic airway inflammation in mice.
      Authors: Hirose K, Wakashin H, Oki M, Kagami S, Suto A, Ikeda K, Watanabe N, Iwamoto I, Furuichi Y, Nakajima H
      Biochem. Biophys. Res. Commun., 2008;374(3):507-11.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    60. CD40L expressed from the canarypox vector, ALVAC, can boost immunogenicity of HIV-1 canarypox vaccine in mice and enhance the in vitro expansion of viral specific CD8+ T cell memory responses from HIV-1-infected and HIV-1-uninfected individuals.
      Authors: Liu J, Yu Q, Stone GW, Yue FY, Ngai N, Jones RB, Kornbluth RS, Ostrowski MA
      Vaccine, 2008;26(32):4062-72.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    61. A novel mechanism for CCR4 in the regulation of macrophage activation in bleomycin-induced pulmonary fibrosis.
      Authors: Trujillo G, O'Connor EC, Kunkel SL, Hogaboam CM
      Am. J. Pathol., 2008;172(5):1209-21.
      Species: Mouse
      Sample Type: Tissue Homogenates
    62. The LTK63 adjuvant improves protection conferred by Ag85B DNA-protein prime-boosting vaccination against Mycobacterium tuberculosis infection by dampening IFN-gamma response.
      Authors: Palma C, Iona E, Giannoni F, Pardini M, Brunori L, Fattorini L, Del Giudice G, Cassone A
      Vaccine, 2008;26(33):4237-43.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    63. Novel immunomodulatory properties of berbamine through selective down-regulation of STAT4 and action of IFN-gamma in experimental autoimmune encephalomyelitis.
      Authors: Ren Y, Lu L, Guo TB, Qiu J, Yang Y, Liu A, Zhang JZ
      J. Immunol., 2008;181(2):1491-8.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    64. IL-13 receptor alpha2 selectively inhibits IL-13-induced responses in the murine lung.
      Authors: Zheng T, Liu W, Oh SY, Zhu Z, Hu B, Homer RJ, Cohn L, Grusby MJ, Elias JA
      J. Immunol., 2008;180(1):522-9.
      Species: Mouse
      Sample Type: BALF
    65. Curcumin attenuates ovalbumin-induced airway inflammation by regulating nitric oxide.
      Authors: Moon DO, Kim MO, Lee HJ, Choi YH, Park YM, Heo MS, Kim GY
      Biochem. Biophys. Res. Commun., 2008;375(2):275-9.
      Species: Mouse
      Sample Type: BALF
    66. Lycopene suppresses ovalbumin-induced airway inflammation in a murine model of asthma.
      Authors: Lee CM, Chang JH, Moon DO, Choi YH, Choi IW, Park YM, Kim GY
      Biochem. Biophys. Res. Commun., 2008;374(2):248-52.
      Species: Mouse
      Sample Type: BALF
    67. Pulmonary eosinophilia requires interleukin-5, eotaxin-1, and CD4+ T cells in mice immunized with respiratory syncytial virus G glycoprotein.
      Authors: Johnson TR, Rothenberg ME, Graham BS
      J. Leukoc. Biol., 2008;84(3):748-59.
      Species: Mouse
      Sample Type: Tissue Homogenates
    68. Allergic pulmonary inflammation in mice is dependent on eosinophil-induced recruitment of effector T cells.
      Authors: Jacobsen EA, Ochkur SI, Pero RS, Taranova AG, Protheroe CA, Colbert DC, Lee NA, Lee JJ
      J. Exp. Med., 2008;205(3):699-710.
      Species: Mouse
      Sample Type: BALF
    69. Antifibrotic action of pirfenidone and prednisolone: different effects on pulmonary cytokines and growth factors in bleomycin-induced murine pulmonary fibrosis.
      Authors: Oku H, Shimizu T, Kawabata T, Nagira M, Hikita I, Ueyama A, Matsushima S, Torii M, Arimura A
      Eur. J. Pharmacol., 2008;590(1):400-8.
      Species: Mouse
      Sample Type: Tissue Homogenates
    70. Distinct roles for IL-13 and IL-4 via IL-13 receptor alpha1 and the type II IL-4 receptor in asthma pathogenesis.
      Authors: Munitz A, Brandt EB, Mingler M, Finkelman FD, Rothenberg ME
      Proc. Natl. Acad. Sci. U.S.A., 2008;105(20):7240-5.
      Species: Mouse
      Sample Type: BALF
    71. Crucial role of the interleukin-6/interleukin-17 cytokine axis in the induction of arthritis by glucose-6-phosphate isomerase.
      Authors: Iwanami K, Matsumoto I, Tanaka-Watanabe Y, Inoue A, Mihara M, Ohsugi Y, Mamura M, Goto D, Ito S, Tsutsumi A, Kishimoto T, Sumida T
      Arthritis Rheum., 2008;58(3):754-63.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    72. Dendritic cells derived from TBP-2-deficient mice are defective in inducing T cell responses.
      Authors: Son A, Nakamura H, Okuyama H, Oka S, Yoshihara E, Liu W, Matsuo Y, Kondo N, Masutani H, Ishii Y, Iyoda T, Inaba K, Yodoi J
      Eur. J. Immunol., 2008;38(5):1358-67.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    73. Thymic stromal lymphopoietin and thymic stromal lymphopoietin-conditioned dendritic cells induce regulatory T-cell differentiation and protection of NOD mice against diabetes.
      Authors: Besin G, Gaudreau S, Menard M, Guindi C, Dupuis G, Amrani A
      Diabetes, 2008;57(8):2107-17.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    74. Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity.
      Authors: Yamanouchi J, Rainbow D, Serra P, Howlett S, Hunter K, Garner VE, Gonzalez-Munoz A, Clark J, Veijola R, Cubbon R, Chen SL, Rosa R, Cumiskey AM, Serreze DV, Gregory S, Rogers J, Lyons PA, Healy B, Smink LJ, Todd JA, Peterson LB, Wicker LS, Santamaria P
      Nat. Genet., 2007;39(3):329-37.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    75. Toll-like receptor 4 (TLR4)-dependent proinflammatory and immunomodulatory properties of the glycoinositolphospholipid (GIPL) from Trypanosoma cruzi.
      Authors: Medeiros MM, Peixoto JR, Oliveira AC, Cardilo-Reis L, Koatz VL, Van Kaer L, Previato JO, Mendonca-Previato L, Nobrega A, Bellio M
      J. Leukoc. Biol., 2007;82(3):488-96.
      Species: Mouse
      Sample Type: Peritoneal Fluid
    76. Toll-like receptor (TLR)2 and TLR3 synergy and cross-inhibition in murine myeloid dendritic cells.
      Authors: Vanhoutte F, Paget C, Breuilh L, Fontaine J, Vendeville C, Goriely S, Ryffel B, Faveeuw C, Trottein F
      Immunol. Lett., 2007;116(1):86-94.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    77. FTY720 ameliorates oxazolone colitis in mice by directly affecting T helper type 2 functions.
      Authors: Daniel C, Sartory NA, Zahn N
      Mol. Immunol., 2007;44(13):3305-16.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    78. The immunomodulation of endotoxin-induced acute lung injury by hesperidin in vivo and in vitro.
      Authors: Yeh CC, Kao SJ, Lin CC, Wang SD, Liu CJ, Kao ST
      Life Sci., 2007;80(20):1821-31.
      Species: Mouse
      Sample Type: BALF
    79. Therapeutic targeting of CC ligand 21 or CC chemokine receptor 7 abrogates pulmonary fibrosis induced by the adoptive transfer of human pulmonary fibroblasts to immunodeficient mice.
      Authors: Pierce EM, Carpenter K, Jakubzick C, Kunkel SL, Flaherty KR, Martinez FJ, Hogaboam CM
      Am. J. Pathol., 2007;170(4):1152-64.
      Species: Mouse
      Sample Type: Tissue Homogenates
    80. Granulocyte-macrophage colony-stimulating factor prevents diabetes development in NOD mice by inducing tolerogenic dendritic cells that sustain the suppressive function of CD4+CD25+ regulatory T cells.
      Authors: Gaudreau S, Guindi C, Menard M, Besin G, Dupuis G, Amrani A
      J. Immunol., 2007;179(6):3638-47.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    81. Lentiviral vector-mediated autonomous differentiation of mouse bone marrow cells into immunologically potent dendritic cell vaccines.
      Authors: Koya RC, Kimura T, Ribas A, Rozengurt N, Lawson GW, Faure-Kumar E, Wang HJ, Herschman H, Kasahara N, Stripecke R
      Mol. Ther., 2007;15(5):971-80.
      Species: Mouse
      Sample Type: Serum
    82. Src homology 2 domain-containing inositol 5-phosphatase 1 deficiency leads to a spontaneous allergic inflammation in the murine lung.
      Authors: Oh SY, Zheng T, Bailey ML, Barber DL, Schroeder JT, Kim YK, Zhu Z
      J. Allergy Clin. Immunol., 2007;119(1):123-31.
      Species: Mouse
      Sample Type: BALF
    83. Prolonged inhaled allergen exposure can induce persistent tolerance.
      Authors: Van Hove CL, Maes T, Joos GF, Tournoy KG
      Am. J. Respir. Cell Mol. Biol., 2007;36(5):573-84.
      Species: Mouse
      Sample Type: BALF
    84. Chronic intranasal administration of mould spores or extracts to unsensitized mice leads to lung allergic inflammation, hyper-reactivity and remodelling.
      Authors: Denis O, van den Brule S, Heymans J, Havaux X, Rochard C, Huaux F, Huygen K
      Immunology, 2007;122(2):268-78.
      Species: Mouse
      Sample Type: BALF
    85. IL-27 suppresses Th2 cell development and Th2 cytokines production from polarized Th2 cells: a novel therapeutic way for Th2-mediated allergic inflammation.
      Authors: Yoshimoto T, Yoshimoto T, Yasuda K, Mizuguchi J, Nakanishi K
      J. Immunol., 2007;179(7):4415-23.
      Species: Mouse
      Sample Type: Serum
    86. Using pCIN-mIL-4 DNA vector to express mRNA and protein and to improve herpes simplex virus-induced Behcet's disease symptoms in mice.
      Authors: Lee SI, Kwon HJ, Lee ES, Yang BC, Bang D, Lee S, Sohn S
      Vaccine, 2007;25(41):7047-55.
      Species: Mouse
      Sample Type: Serum
    87. Critical role of the Fc receptor gamma-chain on APCs in the development of allergen-induced airway hyperresponsiveness and inflammation.
      Authors: Kitamura K, Takeda K, Koya T, Miyahara N, Kodama T, Dakhama A, Takai T, Hirano A, Tanimoto M, Harada M, Gelfand EW
      J. Immunol., 2007;178(1):480-8.
      Species: Mouse
      Sample Type: BALF
    88. D-pinitol regulates Th1/Th2 balance via suppressing Th2 immune response in ovalbumin-induced asthma.
      Authors: Lee JS, Lee CM, Jeong YI, Jung ID, Kim BH, Seong EY, Kim JI, Choi IW, Chung HY, Park YM
      FEBS Lett., 2007;581(1):57-64.
      Species: Mouse
      Sample Type: BALF
    89. Intercellular adhesion molecule-1 expression is required on multiple cell types for the development of experimental autoimmune encephalomyelitis.
      Authors: Bullard DC, Hu X, Schoeb TR, Collins RG, Beaudet AL, Barnum SR
      J. Immunol., 2007;178(2):851-7.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    90. Reversion of immune tolerance in advanced malignancy: modulation of myeloid-derived suppressor cell development by blockade of stem-cell factor function.
      Authors: Pan PY, Wang GX, Yin B, Ozao J, Ku T, Divino CM, Chen SH
      Blood, 2007;111(1):219-28.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    91. Inhalation tolerance is induced selectively in thoracic lymph nodes but executed pervasively at distant mucosal and nonmucosal tissues.
      Authors: Alvarez D, Swirski FK, Yang TC, Fattouh R, Croitoru K, Bramson JL, Stampfli MR, Jordana M
      J. Immunol., 2006;176(4):2568-80.
      Species: Mouse
      Sample Type: Serum
    92. Roles of the small intestine for induction of toll-like receptor 4-mediated innate resistance in naturally acquired murine toxoplasmosis.
      Authors: Furuta T, Yoshikawa Y
      Int. Immunol., 2006;18(12):1655-62.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    93. Allergic airway inflammation inhibits pulmonary antibacterial host defense.
      Authors: Beisswenger C, Kandler K, Hess C, Garn H, Felgentreff K, Wegmann M, Renz H, Vogelmeier C, Bals R
      J. Immunol., 2006;177(3):1833-7.
      Species: Mouse
      Sample Type: BALF
    94. Prevention of murine experimental autoimmune encephalomyelitis by in vivo expression of a novel recombinant immunotoxin DT390-RANTES.
      Authors: Jia Y, Li H, Chen W, Li M, Lv M, Feng P, Hu H, Zhang L
      Gene Ther., 2006;13(18):1351-9.
      Species: Mouse
      Sample Type: Serum
    95. The differential effects of low dose and high dose concanavalin A on cytokine profile and their importance in liver injury.
      Authors: Xu X, Wei H, Dong Z, Chen Y, Tian Z
      Inflamm. Res., 2006;55(4):144-52.
      Species: Mouse
      Sample Type: Serum
    96. Oral administration of an immunostimulatory DNA sequence from Bifidobacterium longum improves Th1/Th2 balance in a murine model.
      Authors: Takahashi N, Kitazawa H, Iwabuchi N, Xiao JZ, Miyaji K, Iwatsuki K, Saito T
      Biosci. Biotechnol. Biochem., 2006;70(8):2013-7.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    97. CCL17 transgenic mice show an enhanced Th2-type response to both allergic and non-allergic stimuli.
      Authors: Tsunemi Y, Saeki H, Nakamura K, Nagakubo D, Nakayama T, Yoshie O, Kagami S, Shimazu K, Kadono T, Sugaya M, Komine M, Matsushima K, Tamaki K
      Eur. J. Immunol., 2006;36(8):2116-27.
      Species: Mouse
      Sample Type: Tissue Homogenates
    98. CD27 contributes to the early systemic immune response to Mycobacterium tuberculosis infection but does not affect outcome.
      Authors: Wieland CW, Kerver ME, Florquin S, Nolte MA, Borst J, van Lier R, van Oers MH, van der Poll T
      Int. Immunol., 2006;18(11):1531-9.
      Species: Mouse
      Sample Type: Tissue Homogenates
    99. Short-term dietary administration of celecoxib enhances the efficacy of tumor lysate-pulsed dendritic cell vaccines in treating murine breast cancer.
      Authors: Hahn T, Alvarez I, Kobie JJ, Ramanathapuram L, Dial S, Fulton A, Besselsen D, Walker E, Akporiaye ET
      Int. J. Cancer, 2006;118(9):2220-31.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    100. Matrix metalloproteinase-8 deficiency promotes granulocytic allergen-induced airway inflammation.
      Authors: Gueders MM, Balbin M, Rocks N, Foidart JM, Gosset P, Louis R, Shapiro S, Lopez-Otin C, Noel A, Cataldo DD
      J. Immunol., 2005;175(4):2589-97.
      Species: Mouse
      Sample Type: BALF
    101. DNA vaccine encoding Der p 2 allergen generates immunologic protection in recombinant Der p 2 allergen-induced allergic airway inflammation mice model.
      Authors: Li GP, Liu ZG, Ran PX, Zhong NS
      Chin. Med. J., 2005;118(7):534-40.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    102. MyD88-dependent induction of allergic Th2 responses to intranasal antigen.
      Authors: Piggott DA, Eisenbarth SC, Xu L, Constant SL, Huleatt JW, Herrick CA, Bottomly K
      J. Clin. Invest., 2005;115(2):459-67.
      Species: Human
      Sample Type: Cell Culture Supernates
    103. Intranasal mite allergen induces allergic asthma-like responses in NC/Nga mice.
      Authors: Shibamori M, Ogino K, Kambayashi Y, Ishiyama H
      Life Sci., 2005;78(9):987-94.
      Species: Mouse
      Sample Type: BALF
    104. Increased and long-term generation of dendritic cells with reduced function from IL-6-deficient bone marrow.
      Authors: Bleier JI, Pillarisetty VG, Shah AB, DeMatteo RP
      J. Immunol., 2004;172(12):7408-16.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    105. Cytokine expression in experimental chronic otitis media with effusion in mice.
      Authors: Maeda K, Hirano T, Ichimiya I, Kurono Y, Suzuki M, Mogi G
      Laryngoscope, 2004;114(11):1967-72.
      Species: Mouse
      Sample Type: Tissue Secretion
    106. Vbeta14(+) T cells mediate the vaccine-enhanced disease induced by immunization with respiratory syncytial virus (RSV) G glycoprotein but not with formalin-inactivated RSV.
      Authors: Johnson TR, Varga SM, Braciale TJ, Graham BS
      J. Virol., 2004;78(16):8753-60.
      Species: Mouse
      Sample Type: Tissue Homogenates
    107. EphrinB1 is essential in T-cell-T-cell co-operation during T-cell activation.
      Authors: Yu G, Luo H, Wu Y, Wu J
      J. Biol. Chem., 2004;279(53):55531-9.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    108. Control of Leishmania major in the absence of Tyk2 kinase.
      Authors: Schleicher U, Mattner J, Blos M, Schindler H, Rollinghoff M, Karaghiosoff M, Muller M, Werner-Felmayer G, Bogdan C
      Eur. J. Immunol., 2004;34(2):519-29.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    109. Increased interleukin-10 associated with low IL-6 concentration correlated with greater survival rates in mice infected by rabies virus vaccinated against it and immunomodulated with P. acnes.
      Authors: Megid J, Kaneno R, Nozaki CN, Brito CJ, Almeida MF
      Comp. Immunol. Microbiol. Infect. Dis., 2004;27(6):393-411.
      Species: Mouse
      Sample Type: Serum
    110. A protective role of locally administered immunostimulatory CpG oligodeoxynucleotide in a mouse model of genital herpes infection.
      Authors: Harandi AM, Eriksson K, Holmgren J
      J. Virol., 2003;77(2):953-62.
      Species: Mouse
      Sample Type: Serum
    111. A profibrotic function of IL-12p40 in experimental pulmonary fibrosis.
      Authors: Huaux F, Arras M, Tomasi D, Barbarin V, Delos M, Coutelier JP, Vink A, Phan SH, Renauld JC, Lison D
      J. Immunol., 2002;169(5):2653-61.
      Species: Mouse
      Sample Type: Tissue Homogenates
    112. Leptin accelerates autoimmune diabetes in female NOD mice.
      Authors: Matarese G, Sanna V, Lechler RI, Sarvetnick N, Fontana S, Zappacosta S, La Cava A
      Diabetes, 2002;51(5):1356-61.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    113. Anti-tumor mechanism of Z-100, an immunomodulatory Arabinomannan extracted from Mycobacterium tuberculosis strain Aoyama B, on pulmonary metastases of B16F10 melanoma: restoration of helper T cell responses via suppression of glucocorticoid-genesis.
      Authors: Oka H, Emori Y, Sasaki H, Shiraishi Y, Yoshinaga K, Kurimoto T
      Microbiol. Immunol., 2002;46(5):343-51.
      Species: Mouse
      Sample Type: Cell Culture Supernates
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     Mouse IL-4 Quantikine ELISA Kit M4000B
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     Mouse IL-4 Quantikine ELISA Kit M4000B
    : Mouse IL-4 Quantikine ELISA Kit [M4000B]

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    Sample TestedMouse lung lysates

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    Other Experimental DetailsThis ELISA works awesomely in mouse lung samples.
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    Sample TestedLung tissue,RAW 264.7 mouse monocyte/macrophage cell line

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