Mouse NFIL3/E4BP4 PE-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: NFIL3/E4BP4

NFIL3 (Nuclear Factor, Interleukin 3 Regulated), also called E4BP4 (adenovirus E4 promoter binding protein 4), is an approximately 58 kDa transcription factor belonging to the bZIP (basic leucine zipper) family. It is a transcriptional regulator expressed in Th2 cells, Th1 cells, pro-B lymphocytes and cardiomyocytes. NFIL3 binds IL-3 and promoters as a homodimer, and enhances cell survival. NFIL3 has also been shown to be involved in the development of Innate Lymphoid Cells (ILCs). The 462 amino acid (aa) human NFIL3 contains a basic DNA binding domain (aa 73-95), a leucine zipper (aa 96-124), and a transcriptional repression domain (aa 299-363) that is potentially regulated by phosphorylation at Ser301 and Ser353. Within the region used as an immunogen, human NFIL3 shares 83% aa sequence identity with mouse and rat NFIL3.

Product Datasheets

Related Research Areas

• ALS Related Molecules
• Apoptosis Transcription Factors and Regulators
• B Cell Development and Differentiation
• Basic Leucine Zipper (bZIP) Transcription Factors
• Conventional/Classical Dendritic Cells
• Gametes and Fertilization
• Hematopoietic Stem Cell Transcription Factors and Regulators
• Osteoblast and Osteoclast Markers
• Th1 Cells
• Th2 Cells
• Transcriptional Regulators in Allergy and Asthma