Mouse PAR2 (NP_032000) VersaClone cDNA Summary
Protease-Activated Receptor 2 (PAR2) is a protease activated 7-transmembrane G-protein-coupled receptor. Human PAR2 contains a cleavage site for trypsin, mast cell tryptase or coagulation factor VIIa or Xa, 11 amino acids (aa) C-terminal to the signal sequence. Cleavage creates a tethered ligand that activates the 361 aa receptor. PAR2 is expressed in kidney, pancreas, stomach, intestine, airway, skin, bladder and brain; activation stimulates release of inflammatory and nociceptive mediators. PAR2 is downregulated by ubiquination, endocytosis and degradation. Mature human PAR2 shows 78% amino acid identity with mouse PAR2 over the extracellular portions.
Citation for Mouse PAR2 (NP_032000) VersaClone cDNA
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1 Citation: Showing 1 - 1
The serine proteinase hepsin is an activator of pro-matrix metalloproteinases: molecular mechanisms and implications for extracellular matrix turnover
Authors: DJ Wilkinson, A Desilets, H Lin, S Charlton, M Del Carmen, A Falconer, C Bullock, YC Hsu, K Birchall, A Hawkins, P Thompson, WR Ferrell, J Lockhart, R Plevin, Y Zhang, E Blain, SW Lin, R Leduc, JM Milner, AD Rowan
Sci Rep, 2017;7(1):16693. 2017
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