Mouse SorCS2 Antibody Summary
Accession # Q9EPR5
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
SorCS2 in Mouse Brain. SorCS2 was detected in perfusion fixed frozen sections of mouse brain using Sheep Anti-Mouse SorCS2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF4237) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Sheep HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS019) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Frozen Tissue Sections.
SorCS2 in Mouse Brain. SorCS2 was detected in perfusion fixed frozen sections of mouse brain using Sheep Anti-Mouse SorCS2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF4237) at 15 µg/mL overnight at 4 °C. Tissue was stained using the NorthernLights™ 557-conjugated Anti-Sheep IgG Secondary Antibody (red; Catalog # NL010) and counterstained with DAPI (blue). View our protocol for Fluorescent IHC Staining of Frozen Tissue Sections.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Mouse SorCS2 is a 110‑130 kDa member of the Vps10p (vacuolar protein sorting 10 protein)-D family of sorting receptors. It is synthesized as a 1159 amino acid (aa) preproprecursor that undergoes proteolytic processing to generate a 1042 aa mature type I transmembrane receptor. The extracellular domain shows an imperfect LRR and a Vps10p domain. SorCS2 is plasma membrane expressed and may undergo proteolytic cleavage. Over aa 118-1078, mouse SorCS2 is 88% and 98% aa identical to human and rat SorCs2, respectively.
Citations for Mouse SorCS2 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
Citations: Showing 1 - 4
Filter your results:
SorCS2 Controls Functional Expression of Amino Acid Transporter EAAT3 and Protects Neurons from Oxidative Stress and Epilepsy-Induced Pathology
Authors: AR Malik, K Szydlowska, K Nizinska, A Asaro, EA van Vliet, O Popp, G Dittmar, R Fritsche-G, JA Kirwan, A Nykjaer, K Lukasiuk, E Aronica, TE Willnow
Cell Rep, 2019;26(10):2792-2804.e6.
Sample Types: Tissue Homogenates
Prions amplify through degradation of the VPS10P sorting receptor sortilin
Authors: K Uchiyama, M Tomita, M Yano, J Chida, H Hara, NR Das, A Nykjaer, S Sakaguchi
PLoS Pathog., 2017;13(6):e1006470.
Sample Types: Cell Lysates
Applications: Western Blot
SorCS2-mediated NR2A trafficking regulates motor deficits in Huntington's disease
Authors: Q Ma, J Yang, TA Milner, JG Vonsattel, ME Palko, L Tessarollo, BL Hempstead
JCI Insight, 2017;2(9):.
Sample Types: Whole Tissue
Disruption of SorCS2 reveals differences in the regulation of stereociliary bundle formation between hair cell types in the inner ear
Authors: A Forge, RR Taylor, SJ Dawson, M Lovett, DJ Jagger
PLoS Genet, 2017;13(3):e1006692.
Sample Types: Whole Tissue
No product specific FAQs exist for this product, however you mayView all Antibody FAQs
Cell and Tissue Staining Kits
Reviews for Mouse SorCS2 Antibody
There are currently no reviews for this product. Be the first to review Mouse SorCS2 Antibody and earn rewards!
Have you used Mouse SorCS2 Antibody?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image