Recombinant Mouse Galectin-3 Protein, CF
Recombinant Mouse Galectin-3 Protein, CF Summary
Recombinant Mouse Galectin-3 (Catalog # 9039-GA) supportsthe adhesion of D10.G4.1 mouse helper T cells. The ED50 for this effect is1-5 μg/mL, while competitor's protein does not have activity.
Galectin-3, also known as Mac-2, L29, CBP35, and epsilon BP, is classified as a chimeric member of the Galectin superfamily and contains one carbohydrate recognition domain (CRD) linked to a nonlectin domain (1, 2). Mature mouse Galectin-3 shares 80% and 86% amino acid (aa) sequence identity with human and rat Galectin-3, respectively. Galectin-3 is a 26 kDa protein that can be nuclear, cytoplasmic, or secreted (3, 4). Nuclear Galectin-3 can modulate gene expression, while cytosolic Galectin-3 can inhibit apoptosis and can participate in exocytosis, Caveolin-mediated endocytosis, and macrophage-mediated clearance of apoptotic cells (5-7). Extracellular Galectin-3 has been shown to form high-order oligomers that promote the crosslinking of cell surface oligosacchraides as well as integrin-dependent cell adhesion and apoptosis (8-11). Galectin-3 contributes to the innate immune response against Candida albicans and Streptococcus pneumoniae, and it can facilitate acute inflammatory responses via neutrophil activation and opsonization, macrophage recruitment, and mast cell activation (12-14). Galectin-3 can also contribute to chronic inflammation and fibrosis (15). It is implicated in neuroinflammatory disorders of the central nervous system, cardiac fibrosis, and heart failure, as well as tumor growth, progression, and metastasis (16-18).
- Robertson, M.W. et al. (1990) Biochemistry 29:8093.
- Elola, M.T. et al. (2007) Cell. Mol. Life Sci. 64:1679.
- Haudek, K.C. et al. (2010) Biochim. Biophys. Acta 1800:181.
- Hughes, R.C. (1999) Biochim. Biophys. Acta 1473:172.
- Krzeslak, A. and A. Lipinska (2004) Cell. Mol. Biol. Lett. 9:305.
- Dumic, J. et al. (2006) Biochim. Biophys. Acta 1760:616.
- Sano, H. et al. (2003) J. Clin. Invest. 112:389.
- Ahmad, N. et al. (2004) J. Biol. Chem. 279:10841.
- Friedrichs, J. et al. (2008) J. Biol. Chem. 283:32264.
- Wen, Y. et al. (2006) J. Cell. Biochem. 98:115.
- Zhuo, Y. et al. (2008) J. Biol. Chem. 283:22177.
- Henderson, N.C. and T. Sethi (2009) Immunol. Rev. 230:160.
- Kohatsu, L. et al. (2006) J. Immunol. 177:471814. Nieminen, J. et al. (2008) J. Immunol. 180:2466.
- Henderson, N.C. et al. (2008) Am. J. Pathol. 172:288.
- Newlaczyl, A.U. and L.G. Yu (2011) Cancer Lett. 313:123.
- Sherwi, N. et al. (2012) Future Cardiol. 8:885.
- Shin, T. (2013) Acta Histochem. 115:407.
No product specific FAQs exist for this product, however you mayView all Proteins and Enzyme FAQs
Reviews for Recombinant Mouse Galectin-3 Protein, CF
There are currently no reviews for this product. Be the first to review Recombinant Mouse Galectin-3 Protein, CF and earn rewards!
Have you used Recombinant Mouse Galectin-3 Protein, CF?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image