Recombinant Mouse IL-6 Protein

Formulations:
Catalog # Availability Size / Price Qty
406-ML-005
406-ML-025
406-ML-200
Recombinant Mouse IL-6 Protein Bioactivity
2 Images
Product Details
Citations (207)
FAQs
Reviews (3)

Recombinant Mouse IL-6 Protein Summary

Purity
>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Level
<0.10 EU per 1 μg of the protein by the LAL method.
Activity
Measured in a cell proliferation assay using T1165.85.2.1 mouse plasmacytoma cells. Nordan, R.P. et al. (1987) J. Immunol. 139:813. The ED50 for this effect is 0.02-0.06 ng/mL.
Source
E. coli-derived mouse IL-6 protein
Phe25-Thr211, with an N-terminal Met
Accession #
N-terminal Sequence
Analysis
Phe25
Predicted Molecular Mass
21.8 kDa

Product Datasheets

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

406-ML

Formulation Lyophilized from a 0.2 μm filtered solution in Sodium Acetate and EDTA with Trehalose and with BSA as a carrier protein.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

406-ML/CF

Formulation Supplied as a 0.2 μm filtered solution in Sodium Acetate and EDTA.
Shipping The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Do not freeze.
  • 6 months from date of receipt, 2 to 8 °C as supplied.

Data Images

Bioactivity Recombinant Mouse IL-6 Protein Bioactivity View Larger

Recombinant Mouse IL-6 (Catalog # 406‑ML) stimulates cell proliferation of the T1165.85.2.1 mouse plasmacytoma cell line. The ED50 for this effect is 0.02‑0.06 ng/mL.

SDS-PAGE Recombinant Mouse IL-6 Protein SDS-PAGE View Larger

1 μg/lane of Recombinant Mouse IL-6 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 24 kDa.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: IL-6

Interleukin-6 (IL-6) is a pleiotropic, alpha -helical, 22 - 28 kDa phosphorylated and variably glycosylated cytokine that plays important roles in the acute phase reaction, inflammation, hematopoiesis, bone metabolism, and cancer progression (1 - 5). Mature mouse IL-6 is 187 amino acids (aa) in length and shares 39% and 85% aa sequence identity with human and rat IL-6, respectively (6 - 8). IL-6 induces signaling through a cell surface heterodimeric receptor complex composed of a ligand binding subunit (IL-6 R alpha) and a signal transducing subunit (gp130). IL-6 binds to IL-6 R alpha, triggering IL-6 R alpha association with gp130 and gp130 dimerization (9). gp130 is also a component of the receptors for CLC, CNTF, CT-1, IL-11, IL-27, LIF, and OSM (10). Soluble forms of IL-6 R alpha are generated by both alternative splicing and proteolytic cleavage (5). In a mechanism known as trans-signaling, complexes of soluble IL-6 and IL-6 R alpha elicit responses from gp130-expressing cells that lack cell surface IL-6 R alpha (5). Trans-signaling enables a wider range of cell types to respond to IL-6, as the expression of gp130 is ubiquitous, while that of IL-6 R alpha is predominantly restricted to hepatocytes, monocytes, and resting lymphocytes (2, 5). Soluble splice forms of gp130 block trans-signaling from IL-6/IL-6 R alpha but not from other cytokines that use gp130 as a co-receptor (5, 11). IL-6, along with TNF-alpha and IL-1, drives the acute inflammatory response and the transition from acute inflammation to either acquired immunity or chronic inflammatory disease (1 - 5). When dysregulated, it contributes to chronic inflammation in obesity, insulin resistance, inflammatory bowel disease, arthritis, sepsis, and atherosclerosis (1, 2, 5). IL-6 can also function as an anti-inflammatory molecule, as in skeletal muscle where it is secreted in response to exercise (2). In addition, it enhances hematopoietic stem cell proliferation and the differentiation of Th17 cells, memory B cells, and plasma cells (1, 12).

References
  1. Mansell, A. and B.J. Jenkins (2013) Cytokine Growth Factor Rev. 24:249.
  2. Schuett, H. et al. (2009) Thromb. Haemost. 102:215.
  3. Erta, M. et al. (2012) Int. J. Biol. Sci. 8:1254.
  4. Garbers, C. et al. (2012) Cytokine Growth Factor Rev. 23:85.
  5. Mihara, M. et al. (2012) Clin. Sci. (Lond.) 122:143.
  6. Chiu, C.P. et al. (1988) Proc. Natl. Acad. Sci. USA 85:7099.
  7. Simpson, R.J. et al. (1988) Eur. J. Biochem. 176:187.
  8. Van Snick, J. et al. (1988) Eur. J. Immunol. 18:193.
  9. Murakami, M. et al. (1993) Science 260:1808.
  10. Muller-Newen, G. (2003) Sci. STKE 2003:PE40.
  11. Mitsuyama, K. et al. (2006) Clin. Exp. Immunol. 143:125.
  12. Cerutti, A. et al. (1998) J. Immunol. 160:2145.
Long Name
Interleukin 6
Entrez Gene IDs
3569 (Human); 16193 (Mouse); 24498 (Rat); 399500 (Porcine); 280826 (Bovine); 403985 (Canine); 100034196 (Equine); 493687 (Feline); 100008733 (Rabbit)
Alternate Names
B cell stimulatory factor-2; B-cell differentiation factor; BSF-2; BSF2CTL differentiation factor; CDF; HGFHSFIFNB2Hybridoma growth factor; IFN-beta-2; IL6; IL-6; IL-6B-cell stimulatory factor 2; Interferon beta-2; interleukin 6 (interferon, beta 2); interleukin BSF-2; interleukin-6; MGI-2A

Citations for Recombinant Mouse IL-6 Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

207 Citations: Showing 1 - 10
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  1. Notch ligand Delta-like 4 induces epigenetic regulation of Treg cell differentiation and function in viral infection
    Authors: HA Ting, D de Almeida, AJ Rasky, CA Malinczak, IP Maillard, MA Schaller, NW Lukacs
    Mucosal Immunol, 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  2. A novel prospective isolation of murine fetal liver progenitors to study in utero hematopoietic defects
    Authors: JE Draper, P Sroczynska, MZH Fadlullah, R Patel, G Newton, W Breitwiese, V Kouskoff, G Lacaud
    PLoS Genet., 2018;14(1):e1007127.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  3. Administration of cytokine-induced myeloid-derived suppressor cells ameliorates renal fibrosis in diabetic mice
    Authors: CC Hsieh, CL Lin, JT He, M Chiang, Y Wang, YC Tsai, CH Hung, PJ Chang
    Stem Cell Res Ther, 2018;9(1):183.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  4. In vivo selection with lentiviral expression of Bcl2T69A/S70A/S87Amutant in hematopoietic stem cell-transplanted mice
    Authors: YY Wang, S Ma, Q Chen, D Jiao, Y Yang
    Gene Ther., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  5. Hydrogen sulfide promotes immunomodulation of gingiva-derived mesenchymal stem cells via the Fas/FasL coupling pathway
    Authors: R Yang, T Yu, D Liu, S Shi, Y Zhou
    Stem Cell Res Ther, 2018;9(1):62.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  6. Hexokinase II may be dispensable for CD4 T cell responses against a virus infection
    Authors: SK Varanasi, U Jaggi, N Hay, BT Rouse
    PLoS ONE, 2018;13(1):e0191533.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  7. Enhanced insulin receptor, but not PI3K, signalling protects podocytes from ER stress
    Authors: KL Garner, VMS Betin, V Pinto, M Graham, E Abgueguen, M Barnes, DC Bedford, CA McArdle, RJM Coward
    Sci Rep, 2018;8(1):3902.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  8. Mesenchymal stem cells ameliorate experimental arthritis via expression of interleukin-1 receptor antagonist
    Authors: K Lee, N Park, H Jung, YA Rim, Y Nam, J Lee, SH Park, JH Ju
    PLoS ONE, 2018;13(2):e0193086.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  9. Physiological culture conditions alter myotube morphology and responses to atrophy treatments: implications for in�vitro research on muscle wasting
    Authors: E Archer-Lah, C Lan, RT Jagoe
    Physiol Rep, 2018;6(12):e13726.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  10. Tumor-extrinsic discoidin domain receptor 1 promotes mammary tumor growth by regulatingadipose stromal interleukin 6 production in mice
    Authors: X Sun, K Gupta, B Wu, D Zhang, B Yuan, X Zhang, HC Chiang, C Zhang, TJ Curiel, MP Bendeck, S Hursting, Y Hu, R Li
    J. Biol. Chem., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  11. Intraperitoneal infusion of mesenchymal stem cell attenuates severity of collagen antibody induced arthritis
    Authors: Y Nam, SM Jung, YA Rim, H Jung, K Lee, N Park, J Kim, Y Jang, YB Park, SH Park, JH Ju
    PLoS ONE, 2018;13(6):e0198740.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  12. Inhibition of Poly(A)-binding protein with a synthetic RNA mimic reduces pain sensitization in mice
    Authors: P Barragán-I, TF Lou, VD Bhat, S Megat, MD Burton, TJ Price, ZT Campbell
    Nat Commun, 2018;9(1):10.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  13. BJ-1108, a 6-Amino-2,4,5-trimethylpyridin-3-ol analogue, regulates differentiation of Th1 and Th17 cells to ameliorate experimental autoimmune encephalomyelitis
    Authors: Y Kang, M Timilshina, TG Nam, BS Jeong, JH Chang
    Biol. Res, 2017;50(1):8.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  14. The mTOR signal regulates myeloid-derived suppressor cells differentiation and immunosuppressive function in acute kidney injury
    Authors: C Zhang, S Wang, J Li, W Zhang, L Zheng, C Yang, T Zhu, R Rong
    Cell Death Dis, 2017;8(3):e2695.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  15. Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia
    Authors: X Jiang, C Hu, K Ferchen, J Nie, X Cui, CH Chen, L Cheng, Z Zuo, W Seibel, C He, Y Tang, JR Skibbe, M Wunderlich, WC Reinhold, L Dong, C Shen, S Arnovitz, B Ulrich, J Lu, H Weng, R Su, H Huang, Y Wang, C Li, X Qin, J Mulloy, Y Zheng, J Diao, J Jin, C Li, PP Liu, C He, Y Chen, J Chen
    Nat Commun, 2017;8(1):2099.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  16. Suppression of Th17 cell differentiation by misshapen/NIK-related kinase MINK1
    Authors: G Fu, Q Xu, Y Qiu, X Jin, T Xu, S Dong, J Wang, Y Ke, H Hu, X Cao, D Wang, H Cantor, X Gao, L Lu
    J. Exp. Med., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  17. The Role of Inflammation in ?-cell Dedifferentiation
    Authors: TM Nordmann, E Dror, F Schulze, S Traub, E Berishvili, C Barbieux, M Böni-Schne, MY Donath
    Sci Rep, 2017;7(1):6285.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  18. Lentivector Iterations and Pre-Clinical Scale-Up/Toxicity Testing: Targeting Mobilized CD34(+) Cells for Correction of Fabry Disease
    Authors: J Huang, A Khan, BC Au, DL Barber, L López-Vásq, NL Prokopishy, M Boutin, M Rothe, JW Rip, M Abaoui, MS Nagree, S Dworski, A Schambach, A Keating, ML West, J Klassen, PV Turner, S Sirrs, CA Rupar, C Auray-Blai, R Foley, JA Medin
    Mol Ther Methods Clin Dev, 2017;5(0):241-258.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  19. Paeoniflorin Ameliorates Experimental Autoimmune Encephalomyelitis via Inhibition of Dendritic Cell Function and Th17 Cell Differentiation
    Authors: H Zhang, Y Qi, Y Yuan, L Cai, H Xu, L Zhang, B Su, H Nie
    Sci Rep, 2017;7(0):41887.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  20. mTORC2 controls Th9 polarization and allergic airway inflammation
    Authors: H Chen, L Zhang, P Wang, H Su, W Wang, Z Chu, L Zhang, X Zhang, Y Zhao
    Allergy, 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  21. Impact of combined sodium chloride and saturated long-chain fatty acid challenge on the differentiation of T helper cells in neuroinflammation
    Authors: A Hammer, A Schliep, S Jörg, A Haghikia, R Gold, M Kleinewiet, DN Müller, RA Linker
    J Neuroinflammation, 2017;14(1):184.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  22. IL-1? and IL-23 Promote Extrathymic Commitment of CD27(+)CD122(-) ?? T Cells to ??T17 Cells
    Authors: A Muschaweck, F Petermann, T Korn
    J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  23. Interferon-gamma regulates inflammatory cell death by targeting necroptosis in experimental autoimmune arthritis
    Authors: SH Lee, JY Kwon, SY Kim, K Jung, ML Cho
    Sci Rep, 2017;7(1):10133.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  24. The excretory-secretory products of Echinococcus granulosus protoscoleces directly regulate the differentiation of B10, B17 and Th17 cells
    Authors: W Pan, WT Hao, YJ Shen, XY Li, YJ Wang, FF Sun, JH Yin, J Zhang, RX Tang, JP Cao, KY Zheng
    Parasit Vectors, 2017;10(1):348.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  25. Suppressive IL-17A(+)Foxp3(+) and ex-Th17 IL-17A(neg)Foxp3(+) Treg cells are a source of tumour-associated Treg cells
    Authors: S Downs-Cann, S Berkey, GM Delgoffe, RP Edwards, T Curiel, K Odunsi, DL Bartlett, N Obermajer
    Nat Commun, 2017;8(0):14649.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  26. Pharmacological Effect ofCaulophyllum robustumon Collagen-Induced Arthritis and Regulation of Nitric Oxide, NF-?B, and Proinflammatory Cytokines In Vivo and In Vitro
    Authors: QH Wang, SW Lv, YY Guo, JX Duan, SY Dong, QS Wang, FM Yu, H Su, HX Kuang
    Evid Based Complement Alternat Med, 2017;2017(0):8134321.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  27. TNF? drives mitochondrial stress in POMC neurons in obesity
    Authors: CX Yi, M Walter, Y Gao, S Pitra, B Legutko, S Kälin, C Layritz, C García-Các, M Bielohuby, M Bidlingmai, SC Woods, A Ghanem, KK Conzelmann, JE Stern, M Jastroch, MH Tschöp
    Nat Commun, 2017;8(0):15143.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  28. Endothelium-derived extracellular vesicles promote splenic monocyte mobilization in myocardial infarction
    Authors: N Akbar, JE Digby, TJ Cahill, AN Tavare, AL Corbin, S Saluja, S Dawkins, L Edgar, N Rawlings, K Ziberna, E McNeill,, E Johnson, AA Aljabali, RA Dragovic, M Rohling, TG Belgard, IA Udalova, DR Greaves, KM Channon, PR Riley, DC Anthony, RP Choudhury
    JCI Insight, 2017;2(17):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  29. M�ller Cell-Derived PEDF Mediates Neuroprotection via STAT3 Activation
    Authors: W Eichler, H Savkovi?-C, S Bürger, M Beck, M Schmidt, P Wiedemann, A Reichenbac, JD Unterlauft
    Cell. Physiol. Biochem., 2017;44(4):1411-1424.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  30. Ndfip1 restricts Th17 cell potency by limiting lineage stability and proinflammatory cytokine production
    Authors: AA Kesewa Lay, S L Sprout, D Phillips, PM Oliver
    Sci Rep, 2017;7(0):39649.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  31. Integrated STAT3 and Ikaros Zinc Finger Transcription Factor Activities Regulate Bcl-6 Expression in CD4(+) Th Cells
    Authors: KA Read, MD Powell, CE Baker, BK Sreekumar, VM Ringel-Sca, H Bachus, RE Martin, ID Cooley, IC Allen, A Ballestero, KJ Oestreich
    J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  32. IL-6 Improves Energy and Glucose Homeostasis in Obesity via Enhanced Central IL-6 trans-Signaling
    Authors: K Timper, JL Denson, SM Steculorum, C Heilinger, L Engström-R, CM Wunderlich, S Rose-John, FT Wunderlich, JC Brüning
    Cell Rep, 2017;19(2):267-280.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  33. Dendritic cell MST1 inhibits Th17 differentiation
    Authors: C Li, Y Bi, Y Li, H Yang, Q Yu, J Wang, Y Wang, H Su, A Jia, Y Hu, L Han, J Zhang, S Li, W Tao, G Liu
    Nat Commun, 2017;8(0):14275.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  34. Stromal Lkb1 deficiency leads to gastrointestinal tumorigenesis involving the IL-11-JAK/STAT3 pathway
    Authors: S Ollila, E Domènech-M, K Laajanen, IP Wong, S Tripathi, N Pentinmikk, Y Gao, Y Yan, EH Niemelä, TC Wang, B Viollet, G Leone, P Katajisto, K Vaahtomeri, TP Mäkelä
    J. Clin. Invest., 2017;0(0):.
    Species: Mouse
    Sample Types: organoid
    Applications: Bioassay
  35. Dual role of ALCAM in neuroinflammation and blood-brain barrier homeostasis
    Authors: MA L‚cuyer, O Saint-Laur, L BourbonniŠ, S Larouche, C Larochelle, L Michel, M Charabati, M Abadier, S Zandee, N Haghayegh, E Gowing, C Pittet, R Lyck, B Engelhardt, A Prat
    Proc. Natl. Acad. Sci. U.S.A, 2017;114(4):E524-E533.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  36. Temporal and tissue-specific requirements for T-lymphocyte IL-6 signalling in obesity-associated inflammation and insulin resistance
    Authors: E Xu, MMA Pereira, I Karakasili, S Theurich, M Al-Maarri, G Rappl, A Waisman, FT Wunderlich, JC Brüning
    Nat Commun, 2017;8(0):14803.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  37. The frequency of Th17�cells in the small intestine exhibits a day-night variation dependent on circadian clock activity
    Authors: HP Thu Le, Y Nakamura, K Oh-Oka, K Ishimaru, S Nakajima, A Nakao
    Biochem. Biophys. Res. Commun., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  38. Selective Induction of Homeostatic Th17 Cells in the Murine Intestine by Cholera Toxin Interacting with the Microbiota
    Authors: Q Zhao, SN Harbour, R Kolde, IJ Latorre, HM Tun, TR Schoeb, H Turner, JJ Moon, E Khafipour, RJ Xavier, CT Weaver, CO Elson
    J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  39. IL-23 restoration of Th17 effector function is independent of IL-6 and TGF-? in a mouse model of alcohol and burn injury
    Authors: X Li, AR Cannon, AM Hammer, NL Morris, MA Choudhry
    J. Leukoc. Biol., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  40. T-cell activation RhoGTPase-activating protein plays an important role in TH17-cell differentiation
    Authors: N Tamehiro, K Nishida, R Yanobu-Tak, M Goto, T Okamura, H Suzuki
    Immunol. Cell Biol., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  41. Progenitor T-cell differentiation from hematopoietic stem cells using Delta-like-4 and VCAM-1
    Authors: S Shukla, MA Langley, J Singh, JM Edgar, M Mohtashami, JC Zúñiga-Pfl, PW Zandstra
    Nat. Methods, 2017;14(5):531-538.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  42. BJ-2266 ameliorates experimental autoimmune encephalomyelitis through down-regulation of the JAK/STAT signaling pathway
    Authors: Z You, M Timilshina, BS Jeong, JH Chang
    Eur. J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  43. Lamtor1 Is Critically Required for CD4(+) T Cell Proliferation and Regulatory T Cell Suppressive Function
    Authors: T Hosokawa, T Kimura, S Nada, T Okuno, D Ito, S Kang, S Nojima, K Yamashita, T Nakatani, Y Hayama, Y Kato, Y Kinehara, M Nishide, N Mikami, S Koyama, H Takamatsu, D Okuzaki, N Ohkura, S Sakaguchi, M Okada, A Kumanogoh
    J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  44. Monocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade
    Authors: M Ouzounova, E Lee, R Piranliogl, A El Andalou, R Kolhe, MF Demirci, D Marasco, I Asm, A Chadli, KA Hassan, M Thangaraju, G Zhou, AS Arbab, JK Cowell, H Korkaya
    Nat Commun, 2017;8(0):14979.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  45. Armc5 deletion causes developmental defects and compromises T-cell immune responses
    Authors: Y Hu, L Lao, J Mao, W Jin, H Luo, T Charpentie, S Qi, J Peng, B Hu, MM Marcinkiew, A Lamarre, J Wu
    Nat Commun, 2017;8(0):13834.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  46. Bone-induced expression of integrin ?3 enables targeted nanotherapy of breast cancer metastases
    Authors: MH Ross, AK Esser, GC Fox, AH Schmieder, X Yang, G Hu, D Pan, X Su, Y Xu, DV Novack, T Walsh, GA Colditz, GH Lukaszewic, E Cordell, JS Novack, JAJ Fitzpatric, DL Waning, KS Mohammad, TA Guise, GM Lanza, KN Weilbaeche
    Cancer Res., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  47. Inhibiting Oxidative Phosphorylation In Vivo Restrains Th17 Effector Responses and Ameliorates Murine Colitis
    Authors: L Franchi, I Monteleone, LY Hao, MA Spahr, W Zhao, X Liu, K Demock, A Kulkarni, CA Lesch, B Sanchez, L Carter, I Marafini, X Hu, O Mashadova, M Yuan, JM Asara, H Singh, CA Lyssiotis, G Monteleone, AW Opipari, GD Glick
    J. Immunol, 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  48. Induction of Colonic Regulatory T Cells by Mesalamine by Activating the Aryl Hydrocarbon Receptor
    Authors: K Oh-Oka, Y Kojima, K Uchida, K Yoda, K Ishimaru, S Nakajima, J Hemmi, H Kano, Y Fujii-Kuri, R Katoh, H Ito, A Nakao
    Cell Mol Gastroenterol Hepatol, 2017;4(1):135-151.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  49. Stat3 as a potential therapeutic target for rheumatoid arthritis
    Authors: T Oike, Y Sato, T Kobayashi, K Miyamoto, S Nakamura, Y Kaneko, S Kobayashi, K Harato, H Saya, M Matsumoto, M Nakamura, Y Niki, T Miyamoto
    Sci Rep, 2017;7(1):10965.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  50. Absence of Notch1 in murine myeloid cells attenuates the development of experimental autoimmune encephalomyelitis by affecting Th1 and Th17 priming
    Authors: M Fernández, EM Monsalve, S López-Lópe, A Ruiz-Garcí, S Mellado, E Caminos, JJ García-Ram, J Laborda, P Tranque, MJM Díaz-Guerr
    Eur. J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  51. Interaction of reactive astrocytes with type I collagen induces astrocytic scar formation through the integrin-N-cadherin pathway after spinal cord injury
    Authors: M Hara, K Kobayakawa, Y Ohkawa, H Kumamaru, K Yokota, T Saito, K Kijima, S Yoshizaki, K Harimaya, Y Nakashima, S Okada
    Nat. Med., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  52. Fibroblast Growth Factor 21 Deficiency Attenuates Experimental Colitis-Induced Adipose Tissue Lipolysis
    Authors: L Liu, C Zhao, Y Yang, X Kong, T Shao, L Ren, X Zhuang, B Yin, G Dryden, C McClain, W Luan, W Feng
    Gastroenterol Res Pract, 2017;2017(0):3089378.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  53. The MNK - eIF4E signaling axis contributes to injury-induced nociceptive plasticity and the development of chronic pain
    Authors: JK Moy, A Khoutorsky, MN Asiedu, BJ Black, JL Kuhn, P Barragán-I, S Megat, MD Burton, CC Burgos-Veg, OK Melemedjia, S Boitano, J Vagner, CG Gkogkas, JJ Pancrazio, JS Mogil, G Dussor, N Sonenberg, TJ Price
    J. Neurosci., 2017;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  54. Attenuation of PKR-like ER Kinase (PERK) Signaling Selectively Controls Endoplasmic Reticulum Stress-induced Inflammation Without Compromising Immunological Responses
    Authors: LN Guthrie, K Abiraman, ES Plyler, NT Sprenkle, SA Gibson, BC McFarland, R Rajbhandar, AL Rowse, EN Benveniste, GP Meares
    J. Biol. Chem., 2016;291(30):15830-40.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  55. T cells are necessary for ILC2 activation in house dust mite-induced allergic airway inflammation in mice
    Authors: BW Li, MJ de Bruijn, I Tindemans, M Lukkes, A KleinJan, HC Hoogsteden, RW Hendriks
    Eur J Immunol, 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  56. P311 induces the transdifferentiation of epidermal stem cells to myofibroblast-like cells by stimulating transforming growth factor ?1 expression
    Stem Cell Res Ther, 2016;7(1):175.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  57. Alternative splicing of MALT1 controls signalling and activation of CD4(+) T cells
    Authors: I Meininger, RA Griesbach, D Hu, T Gehring, T Seeholzer, A Bertossi, J Kranich, A Oeckinghau, AC Eitelhuber, U Greczmiel, A Gewies, M Schmidt-Su, J Ruland, T Brocker, V Heissmeyer, F Heyd, D Krappmann
    Nat Commun, 2016;7(0):11292.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  58. Phenotypic and Functional Plasticity of Murine Intestinal NKp46+ Group 3 Innate Lymphoid Cells
    J Immunol, 2016;196(11):4731-8.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  59. Negative regulation of the hepatic fibrogenic response by suppressor of cytokine signaling 1
    Cytokine, 2016;82(0):58-69.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  60. Pharmacologic modulation of ROR?t translates to efficacy in preclinical and translational models of psoriasis and inflammatory arthritis
    Sci Rep, 2016;6(0):37977.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  61. Lung epithelial tip progenitors integrate glucocorticoid- and STAT3-mediated signals to control progeny fate
    Authors: Emma L Rawlins
    Development, 2016;143(20):3686-3699.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  62. Enhanced immunoregulation of mesenchymal stem cells by IL-10-producing type 1 regulatory T cells in collagen-induced arthritis
    Authors: Jung-Yeon Lim
    Sci Rep, 2016;6(0):26851.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: Bioassay
  63. Leptin directly promotes T-cell glycolytic metabolism to drive effector T-cell differentiation in a mouse model of autoimmunity
    Eur J Immunol, 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  64. Impaired Epidermal to Dendritic T Cell Signaling Slows Wound Repair in Aged Skin
    Authors: Elaine Fuchs
    Cell, 2016;167(5):1323-1338.e14.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  65. Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptor-associated kinase-4 phosphorylation
    Authors: Ian P Salt
    Mol. Cell. Endocrinol., 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  66. RGS10 deficiency ameliorates the severity of disease in experimental autoimmune encephalomyelitis.
    Authors: Lee J, Kannarkat G, Chung J, Joon Lee H, Graham K, Tansey M
    J Neuroinflammation, 2016;13(1):24.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  67. Chronic myelogenous leukemia initiating cells require Polycomb group protein EZH2
    Cancer Discov, 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  68. p(70S6K1) in the TORC1 pathway is essential for the differentiation of Th17 Cells, but not Th1, Th2, or Treg cells in mice.
    Authors: Sasaki C, Chen G, Munk R, Eitan E, Martindale J, Longo D, Ghosh P
    Eur J Immunol, 2016;46(1):212-22.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  69. Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins
    Nat. Med., 2016;22(6):672-8.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  70. Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency
    Stem Cell Reports, 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  71. Renalase expression by melanoma and tumor associated-macrophages promotes tumor growth through a STAT3-mediated mechanism
    Cancer Res, 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  72. The role of local IL6/JAK2/STAT3 signaling in high glucose-induced podocyte hypertrophy
    Kidney Res Clin Pract, 2016;35(4):212-218.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  73. Young microglia restore amyloid plaque clearance of aged microglia
    Authors: Anna Daria
    EMBO J, 2016;0(0):.
    Species: Mouse
    Sample Types: Complex Sample Type
    Applications: Bioassay
  74. Toll/Interleukin-1 Receptor Domain Derived from TcpC (TIR-TcpC) Ameliorates Experimental Autoimmune Arthritis by Down-modulating Th17 Cell Response
    Authors: Shweta Pasi
    J Biol Chem, 2016;291(23):12358-69.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  75. Interleukin-6 Stimulates Defective Angiogenesis.
    Authors: Gopinathan G, Milagre C, Pearce O, Reynolds L, Hodivala-Dilke K, Leinster D, Zhong H, Hollingsworth R, Thompson R, Whiteford J, Balkwill F
    Cancer Res, 2015;75(15):3098-107.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  76. A Key Role for Leukemia Inhibitory Factor in C26 Cancer Cachexia.
    Authors: Seto D, Kandarian S, Jackman R
    J Biol Chem, 2015;290(32):19976-86.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  77. ShcA regulates late stages of T cell development and peripheral CD4+ T cell numbers.
    Authors: Buckley M, Trampont P, Arandjelovic S, Fond A, Juncadella I, Ravichandran K
    J Immunol, 2015;194(4):1665-76.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  78. KIM-1-mediated phagocytosis reduces acute injury to the kidney.
    Authors: Yang L, Brooks C, Xiao S, Sabbisetti V, Yeung M, Hsiao L, Ichimura T, Kuchroo V, Bonventre J
    J Clin Invest, 2015;125(4):1620-36.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: ELISA Standard
  79. Grb10 is involved in BCR-ABL-positive leukemia in mice.
    Authors: Illert, A L, Albers, C, Kreutmair, S, Leischner, H, Peschel, C, Miething, C, Duyster, J
    Leukemia, 2015;29(4):858-68.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  80. Immune requirements for protective Th17 recall responses to Mycobacterium tuberculosis challenge.
    Authors: Monin L, Griffiths K, Slight S, Lin Y, Rangel-Moreno J, Khader S
    Mucosal Immunol, 2015;8(5):1099-109.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  81. Testosterone suppresses hepatic inflammation by the downregulation of IL-17, CXCL-9, and CXCL-10 in a mouse model of experimental acute cholangitis.
    Authors: Schwinge D, Carambia A, Quaas A, Krech T, Wegscheid C, Tiegs G, Prinz I, Lohse A, Herkel J, Schramm C
    J Immunol, 2015;194(6):2522-30.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  82. Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells.
    Authors: Rutz S, Kayagaki N, Phung Q, Eidenschenk C, Noubade R, Wang X, Lesch J, Lu R, Newton K, Huang O, Cochran A, Vasser M, Fauber B, DeVoss J, Webster J, Diehl L, Modrusan Z, Kirkpatrick D, Lill J, Ouyang W, Dixit V
    Nature, 2015;518(7539):417-21.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  83. Identification of modulators of the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha) in a mouse liver gene expression compendium.
    Authors: Oshida K, Vasani N, Thomas R, Applegate D, Rosen M, Abbott B, Lau C, Guo G, Aleksunes L, Klaassen C, Corton J
    PLoS ONE, 2015;10(2):e0112655.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  84. ROR inverse agonist suppresses insulitis and prevents hyperglycemia in a mouse model of type 1 diabetes.
    Authors: Solt L, Banerjee S, Campbell S, Kamenecka T, Burris T
    Endocrinology, 2015;156(3):869-81.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  85. Identification of Tetraazacyclic Compounds as Novel Potent Inhibitors Antagonizing RORgammat Activity and Suppressing Th17 Cell Differentiation.
    Authors: Ding Q, Zhao M, Yu B, Bai C, Huang Z
    PLoS ONE, 2015;10(9):e0137711.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  86. Autocrine amplification of immature myeloid cells by IL-6 in multiple myeloma-infiltrated bone marrow.
    Authors: Matthes T, Manfroi B, Zeller A, Dunand-Sauthier I, Bogen B, Huard B
    Leukemia, 2015;29(9):1882-90.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  87. T-cell-restricted T-bet overexpression induces aberrant hematopoiesis of myeloid cells and impairs function of macrophages in the lung.
    Authors: Iriguchi S, Kikuchi N, Kaneko S, Noguchi E, Morishima Y, Matsuyama M, Yoh K, Takahashi S, Nakauchi H, Ishii Y
    Blood, 2015;125(2):370-82.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  88. Coexistent ARID1A-PIK3CA mutations promote ovarian clear-cell tumorigenesis through pro-tumorigenic inflammatory cytokine signalling.
    Authors: Chandler, Ronald L, Damrauer, Jeffrey, Raab, Jesse R, Schisler, Jonathan, Wilkerson, Matthew, Didion, John P, Starmer, Joshua, Serber, Daniel, Yee, Della, Xiong, Jessie, Darr, David B, Pardo-Manuel de Villena, Fernando, Kim, William, Magnuson, Terry
    Nat Commun, 2015;6(0):6118.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  89. CXCL13 antibody for the treatment of autoimmune disorders.
    Authors: Klimatcheva E, Pandina T, Reilly C, Torno S, Bussler H, Scrivens M, Jonason A, Mallow C, Doherty M, Paris M, Smith E, Zauderer M
    BMC Immunol, 2015;16(0):6.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  90. Mouse Resistin (mRetn): cloning, expression and purification in Escherichia coli and the potential regulative effects on murine bone marrow hematopoiesis.
    Authors: Wang F, Gao J, Malisani A, Xi X, Han W, Wan X
    BMC Biotechnol, 2015;15(0):105.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  91. IkappaBNS regulates murine Th17 differentiation during gut inflammation and infection.
    Authors: Annemann M, Wang Z, Plaza-Sirvent C, Glauben R, Schuster M, Ewald Sander F, Mamareli P, Kuhl A, Siegmund B, Lochner M, Schmitz I
    J Immunol, 2015;194(6):2888-98.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  92. IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iTreg cell balance.
    Authors: Basu R, Whitley S, Bhaumik S, Zindl C, Schoeb T, Benveniste E, Pear W, Hatton R, Weaver C
    Nat Immunol, 2015;16(3):286-95.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  93. miR-148a is upregulated by Twist1 and T-bet and promotes Th1-cell survival by regulating the proapoptotic gene Bim.
    Authors: Haftmann C, Stittrich A, Zimmermann J, Fang Z, Hradilkova K, Bardua M, Westendorf K, Heinz G, Riedel R, Siede J, Lehmann K, Weinberger E, Zimmel D, Lauer U, Haupl T, Sieper J, Backhaus M, Neumann C, Hoffmann U, Porstner M, Chen W, Grun J, Baumgrass R, Matz M, Lohning M, Scheffold A, Wittmann J, Chang H, Rajewsky N, Jack H, Radbruch A, Mashreghi M
    Eur J Immunol, 2015;45(4):1192-205.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  94. Mesenchymal stem/stromal cells protect against autoimmunity via CCL2-dependent recruitment of myeloid-derived suppressor cells.
    Authors: Lee H, Ko J, Jeong H, Ko A, Kim M, Wee W, Yoon S, Oh J
    J Immunol, 2015;194(8):3634-45.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  95. Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity.
    Authors: Ramkhelawon B, Hennessy E, Menager M, Ray T, Sheedy F, Hutchison S, Wanschel A, Oldebeken S, Geoffrion M, Spiro W, Miller G, McPherson R, Rayner K, Moore K
    Nat Med, 2014;20(4):377-84.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  96. The DNA binding property of PML/RARA but not the integrity of PML nuclear bodies is indispensable for leukemic transformation.
    Authors: Liu X, Yuan H, Peres L, Chen S, Chen Z, de The H, Zhou J, Zhu J
    PLoS ONE, 2014;9(8):e104906.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  97. TGFbeta-mediated suppression of CD248 in non-cancer cells via canonical Smad-dependent signaling pathways is uncoupled in cancer cells.
    Authors: Suresh Babu S, Valdez Y, Xu A, O'Byrne A, Calvo F, Lei V, Conway E
    BMC Cancer, 2014;14(0):113.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  98. Hes1 promotes blast crisis in chronic myelogenous leukemia through MMP-9 upregulation in leukemic cells.
    Authors: Nakahara F, Kitaura J, Uchida T, Nishida C, Togami K, Inoue D, Matsukawa T, Kagiyama Y, Enomoto Y, Kawabata K, Chen-Yi L, Komeno Y, Izawa K, Oki T, Nagae G, Harada Y, Harada H, Otsu M, Aburatani H, Heissig B, Hattori K, Kitamura T
    Blood, 2014;123(25):3932-42.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  99. Unique macrophages different from M1/M2 macrophages inhibit T cell mitogenesis while upregulating Th17 polarization.
    Authors: Tatano Y, Shimizu T, Tomioka H
    Sci Rep, 2014;4(0):4146.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  100. miR-20b suppresses Th17 differentiation and the pathogenesis of experimental autoimmune encephalomyelitis by targeting RORgammat and STAT3.
    Authors: Zhu E, Wang X, Zheng B, Wang Q, Hao J, Chen S, Zhao Q, Zhao L, Wu Z, Yin Z
    J Immunol, 2014;192(12):5599-609.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  101. Chemically modified DNA aptamers bind interleukin-6 with high affinity and inhibit signaling by blocking its interaction with interleukin-6 receptor.
    Authors: Gupta, Shashi, Hirota, Masao, Waugh, Sheela M, Murakami, Ikuo, Suzuki, Tomoki, Muraguchi, Masahiro, Shibamori, Masafumi, Ishikawa, Yuichi, Jarvis, Thale C, Carter, Jeffrey, Zhang, Chi, Gawande, Bharat, Vrkljan, Michael, Janjic, Nebojsa, Schneider, Daniel J
    J Biol Chem, 2014;289(12):8706-19.
    Species: N/A
    Sample Types: Complex Sample Type
    Applications: Bioassay
  102. Unexpected phenotype of mice lacking Shcbp1, a protein induced during T cell proliferation.
    Authors: Buckley M, Arandjelovic S, Trampont P, Kim T, Braciale T, Ravichandran K
    PLoS ONE, 2014;9(8):e105576.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  103. Gene therapy delivery of myelin oligodendrocyte glycoprotein (MOG) via hematopoietic stem cell transfer induces MOG-specific B cell deletion.
    Authors: Chung, Jie-Yu, Figgett, William, Fairfax, Kirsten, Bernard, Claude, Chan, James, Toh, Ban-Hock, Mackay, Fabienne, Alderuccio, Frank
    J Immunol, 2014;192(6):2593-601.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  104. Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin.
    Authors: Mauer J, Chaurasia B, Goldau J, Vogt M, Ruud J, Nguyen K, Theurich S, Hausen A, Schmitz J, Bronneke H, Estevez E, Allen T, Mesaros A, Partridge L, Febbraio M, Chawla A, Wunderlich F, Bruning J
    Nat Immunol, 2014;15(5):423-30.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  105. TGF-beta signaling initiated in dendritic cells instructs suppressive effects on Th17 differentiation at the site of neuroinflammation.
    Authors: Speck S, Lim J, Shelake S, Matka M, Stoddard J, Farr A, Kuchroo V, Laouar Y
    PLoS ONE, 2014;9(7):e102390.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: ELISA Standard
  106. Macrophage-inducing FasL on chondrocytes forms immune privilege in cartilage tissue engineering, enhancing in vivo regeneration.
    Authors: Fujihara Y, Takato T, Hoshi K
    Stem Cells, 2014;32(5):1208-19.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  107. Therapeutic efficacy of suppressing the Jak/STAT pathway in multiple models of experimental autoimmune encephalomyelitis.
    Authors: Liu Y, Holdbrooks A, De Sarno P, Rowse A, Yanagisawa L, McFarland B, Harrington L, Raman C, Sabbaj S, Benveniste E, Qin H
    J Immunol, 2014;192(1):59-72.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  108. Altered inactivation of commensal LPS due to acyloxyacyl hydrolase deficiency in colonic dendritic cells impairs mucosal Th17 immunity.
    Authors: Janelsins, Brian M, Lu, Mingfang, Datta, Sandip K
    Proc Natl Acad Sci U S A, 2014;111(1):373-8.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  109. Suppression of Th1-mediated autoimmunity by embryonic stem cell-derived dendritic cells.
    Authors: Ikeda T, Hirata S, Takamatsu K, Haruta M, Tsukamoto H, Ito T, Uchino M, Ando Y, Nagafuchi S, Nishimura Y, Senju S
    PLoS ONE, 2014;9(12):e115198.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  110. Dual-specificity phosphatase 14 (DUSP14/MKP6) negatively regulates TCR signaling by inhibiting TAB1 activation.
    Authors: Yang C, Li J, Chiu L, Lan J, Chen D, Chuang H, Huang C, Tan T
    J Immunol, 2014;192(4):1547-57.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  111. IL-21 induces IL-22 production in CD4+ T cells.
    Authors: Yeste A, Mascanfroni I, Nadeau M, Burns E, Tukpah A, Santiago A, Wu C, Patel B, Kumar D, Quintana F
    Nat Commun, 2014;5(0):3753.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  112. M2 kupffer cells promote hepatocyte senescence: an IL-6-dependent protective mechanism against alcoholic liver disease.
    Authors: Wan J, Benkdane M, Alons E, Lotersztajn S, Pavoine C
    Am J Pathol, 2014;184(6):1763-72.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  113. The type I BMP receptor Alk3 is required for the induction of hepatic hepcidin gene expression by interleukin-6.
    Authors: Mayeur, Claire, Lohmeyer, Lisa K, Leyton, Patricio, Kao, Sonya M, Pappas, Alexandr, Kolodziej, Starsha, Spagnolli, Ester, Yu, Binglan, Galdos, Rita L, Yu, Paul B, Peterson, Randall, Bloch, Donald B, Bloch, Kenneth, Steinbicker, Andrea U
    Blood, 2014;123(14):2261-8.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  114. IL-6/STAT3 promotes regeneration of airway ciliated cells from basal stem cells.
    Authors: Tadokoro, Tomomi, Wang, Yang, Barak, Larry S, Bai, Yushi, Randell, Scott H, Hogan, Brigid L
    Proc Natl Acad Sci U S A, 2014;111(35):E3641-9.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  115. Role of IL-6 in exercise training- and cold-induced UCP1 expression in subcutaneous white adipose tissue.
    Authors: Knudsen J, Murholm M, Carey A, Bienso R, Basse A, Allen T, Hidalgo J, Kingwell B, Febbraio M, Hansen J, Pilegaard H
    PLoS ONE, 2014;9(1):e84910.
    Species: Mouse
    Sample Types: In Vivo
    Applications: InVivo
  116. PERK-dependent activation of JAK1 and STAT3 contributes to endoplasmic reticulum stress-induced inflammation.
    Authors: Meares G, Liu Y, Rajbhandari R, Qin H, Nozell S, Mobley J, Corbett J, Benveniste E
    Mol Cell Biol, 2014;34(20):3911-25.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  117. Elongated TCR alpha chain CDR3 favors an altered CD4 cytokine profile.
    Authors: Reynolds C, Chong D, Raynsford E, Quigley K, Kelly D, Llewellyn-Hughes J, Altmann D, Boyton R
    BMC Biol, 2014;12(0):32.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  118. Proinflammatory cytokines differentially regulate adipocyte mitochondrial metabolism, oxidative stress, and dynamics.
    Authors: Hahn W, Kuzmicic J, Burrill J, Donoghue M, Foncea R, Jensen M, Lavandero S, Arriaga E, Bernlohr D
    Am J Physiol Endocrinol Metab, 2014;306(9):E1033-45.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  119. Glimepiride reduces CD14 expression and cytokine secretion from macrophages.
    Authors: Ingham V, Williams A, Bate C
    J Neuroinflammation, 2014;11(0):115.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: ELISA Standard
  120. Increased IL-6 expression in osteoclasts is necessary but not sufficient for the development of Paget's disease of bone.
    Authors: Teramachi J, Zhou H, Subler M, Kitagawa Y, Galson D, Dempster D, Windle J, Kurihara N, Roodman G
    J Bone Miner Res, 2014;29(6):1456-65.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  121. Role of Blimp-1 in programing Th effector cells into IL-10 producers.
    Authors: Neumann C, Heinrich F, Neumann K, Junghans V, Mashreghi M, Ahlers J, Janke M, Rudolph C, Mockel-Tenbrinck N, Kuhl A, Heimesaat M, Esser C, Im S, Radbruch A, Rutz S, Scheffold A
    J Exp Med, 2014;211(9):1807-19.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  122. Attenuation of experimental colitis in glutathione peroxidase 1 and catalase double knockout mice through enhancing regulatory T cell function.
    Authors: Kim H, Lee A, Choi E, Kie J, Lim W, Lee H, Moon B, Seoh J
    PLoS ONE, 2014;9(4):e95332.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  123. IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39.
    Authors: Mascanfroni, Ivan D, Yeste, Ada, Vieira, Silvio M, Burns, Evan J, Patel, Bonny, Sloma, Ido, Wu, Yan, Mayo, Lior, Ben-Hamo, Rotem, Efroni, Sol, Kuchroo, Vijay K, Robson, Simon C, Quintana, Francisc
    Nat Immunol, 2013;14(10):1054-63.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  124. Regulatory B cells suppress imiquimod-induced, psoriasis-like skin inflammation.
    Authors: Yanaba K, Kamata M, Ishiura N, Shibata S, Asano Y, Tada Y, Sugaya M, Kadono T, Tedder T, Sato S
    J Leukoc Biol, 2013;94(4):563-73.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  125. MicroRNA-132 suppresses autoimmune encephalomyelitis by inducing cholinergic anti-inflammation: a new Ahr-based exploration.
    Authors: Hanieh H, Alzahrani A
    Eur J Immunol, 2013;43(10):2771-82.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  126. Induction of a hemogenic program in mouse fibroblasts.
    Authors: Pereira C, Chang B, Qiu J, Niu X, Papatsenko D, Hendry C, Clark N, Nomura-Kitabayashi A, Kovacic J, Ma'ayan A, Schaniel C, Lemischka I, Moore K
    Cell Stem Cell, 2013;13(2):205-18.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  127. Kynurenine 3-monooxygenase mediates inhibition of Th17 differentiation via catabolism of endogenous aryl hydrocarbon receptor ligands.
    Authors: Stephens G, Wang Q, Swerdlow B, Bhat G, Kolbeck R, Fung M
    Eur J Immunol, 2013;43(7):1727-34.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  128. Identification of transcription factors for lineage-specific ESC differentiation.
    Authors: Yamamizu K, Piao Y, Sharov A, Zsiros V, Yu H, Nakazawa K, Schlessinger D, Ko M
    Stem Cell Reports, 2013;1(6):545-59.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  129. Innate Stat3-mediated induction of the antimicrobial protein Reg3gamma is required for host defense against MRSA pneumonia.
    Authors: Choi S, McAleer J, Zheng M, Pociask D, Kaplan M, Qin S, Reinhart T, Kolls J
    J Exp Med, 2013;210(3):551-61.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  130. PI3-kinase gamma promotes Rap1a-mediated activation of myeloid cell integrin alpha4beta1, leading to tumor inflammation and growth.
    Authors: Schmid M, Franco I, Kang S, Hirsch E, Quilliam L, Varner J
    PLoS ONE, 2013;8(4):e60226.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  131. Acteoside suppresses RANKL-mediated osteoclastogenesis by inhibiting c-Fos induction and NF-kappaB pathway and attenuating ROS production.
    Authors: Lee S, Lee K, Yi S, Kook S, Lee J
    PLoS ONE, 2013;8(12):e80873.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: cell culture
  132. Exposure to atmospheric particulate matter enhances Th17 polarization through the aryl hydrocarbon receptor.
    Authors: van Voorhis, Michael, Knopp, Samantha, Julliard, Walker, Fechner, John H, Zhang, Xiaoji, Schauer, James J, Mezrich, Joshua D
    PLoS ONE, 2013;8(12):e82545.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: cell culture
  133. Myeloid-derived suppressor cells regulate growth of multiple myeloma by inhibiting T cells in bone marrow.
    Authors: Ramachandran, Indu R, Martner, Anna, Pisklakova, Alexandr, Condamine, Thomas, Chase, Tess, Vogl, Thomas, Roth, Johannes, Gabrilovich, Dmitry, Nefedova, Yulia
    J Immunol, 2013;190(7):3815-23.
  134. p53 controls autoimmune arthritis via STAT-mediated regulation of the Th17 cell/Treg cell balance in mice.
    Authors: Park J, Lim M, Cho M, Ryu J, Moon Y, Jhun J, Byun J, Kim E, Hwang S, Ju J, Kwok S, Kim H
    Arthritis Rheum, 2013;65(4):949-59.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  135. The soluble interleukin-6 receptor is a mediator of hematopoietic and skeletal actions of parathyroid hormone.
    Authors: Cho S, Pirih F, Koh A, Michalski M, Eber M, Ritchie K, Sinder B, Oh S, Al-Dujaili S, Lee J, Kozloff K, Danciu T, Wronski T, McCauley L
    J Biol Chem, 2013;288(10):6814-25.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  136. T helper type 17 cells contribute to anti-tumour immunity and promote the recruitment of T helper type 1 cells to the tumour.
    Authors: Nunez S, Saez J, Fernandez D, Flores-Santibanez F, Alvarez K, Tejon G, Ruiz P, Maldonado P, Hidalgo Y, Manriquez V, Bono M, Rosemblatt M, Sauma D
    Immunology, 2013;139(1):61-71.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  137. Interferon gamma suppresses collagen-induced arthritis by regulation of Th17 through the induction of indoleamine-2,3-deoxygenase.
    Authors: Lee J, Lee J, Park M, Lim M, Park E, Kim E, Yang E, Lee S, Jhun J, Park S, Kim H, Cho M
    PLoS ONE, 2013;8(4):e60900.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  138. CDK8 kinase phosphorylates transcription factor STAT1 to selectively regulate the interferon response.
    Authors: Bancerek J, Poss Z, Steinparzer I, Sedlyarov V, Pfaffenwimmer T, Mikulic I, Dolken L, Strobl B, Muller M, Taatjes D, Kovarik P
    Immunity, 2013;38(2):250-62.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  139. CXCL1 can be regulated by IL-6 and promotes granulocyte adhesion to brain capillaries during bacterial toxin exposure and encephalomyelitis.
    Authors: Roy M, Richard JF, Dumas A, Vallieres L
    J Neuroinflammation, 2012;9(0):18.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  140. Hepatocyte-specific mutation of both NF-kappaB RelA and STAT3 abrogates the acute phase response in mice.
    Authors: Quinton LJ, Blahna MT, Jones MR, Allen E, Ferrari JD, Hilliard KL, Zhang X, Sabharwal V, Algul H, Akira S, Schmid RM, Pelton SI, Spira A, Mizgerd JP
    J. Clin. Invest., 2012;122(5):1758-63.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  141. Sphingosine-1-phosphate enhances satellite cell activation in dystrophic muscles through a S1PR2/STAT3 signaling pathway.
    Authors: Loh KC, Leong WI, Carlson ME
    PLoS ONE, 2012;7(5):e37218.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  142. Interleukin 7 (IL-7) selectively promotes mouse and human IL-17-producing gammadelta cells.
    Authors: Michel M, Pang D, Haque S, Potocnik A, Pennington D, Hayday A
    Proc Natl Acad Sci U S A, 2012;109(43):17549-54.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  143. Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth.
    Authors: Bruchard M, Mignot G, Derangere V, Chalmin F, Chevriaux A, Vegran F, Boireau W, Simon B, Ryffel B, Connat J, Kanellopoulos J, Martin F, Rebe C, Apetoh L, Ghiringhelli F
    Nat Med, 2012;19(1):57-64.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  144. Host-derived MCP-1 and MIP-1alpha regulate protective anti-tumor immunity to localized and metastatic B16 melanoma.
    Authors: Nakasone Y, Fujimoto M, Matsushita T, Hamaguchi Y, Huu DL, Yanaba M, Sato S, Takehara K, Hasegawa M
    Am. J. Pathol., 2012;180(1):365-74.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  145. Hepatocarcinogenesis in FXR-/- mice mimics human HCC progression that operates through HNF1alpha regulation of FXR expression.
    Authors: Liu N, Meng Z, Lou G, Zhou W, Wang X, Zhang Y, Zhang L, Liu X, Yen Y, Lai L, Forman BM, Xu Z, Xu R, Huang W
    Mol. Endocrinol., 2012;26(5):775-85.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  146. Regulation of innate CD8+ T-cell activation mediated by cytokines.
    Proc Natl Acad Sci U S A, 2012;109(25):9971-6.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  147. Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells.
    Nat. Med., 2012;1248(0):18.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  148. IL-6 activates STAT5 in T cells.
    Authors: Tormo AJ, Letellier MC, Sharma M, Elson G, Crabe S, Gauchat JF
    Cytokine, 2012;60(0):575.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  149. Smad1 signaling restricts hematopoietic potential after promoting hemangioblast commitment.
    Authors: Cook BD, Liu S, Evans T
    Blood, 2011;117(24):6489-97.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  150. The effect of conditional EFNB1 deletion in the T cell compartment on T cell development and function.
    Authors: Jin W, Qi S, Luo H
    BMC Immunol., 2011;12(0):68.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  151. Leukemia inhibitory factor inhibits T helper 17 cell differentiation and confers treatment effects of neural progenitor cell therapy in autoimmune disease.
    Authors: Cao W, Yang Y, Wang Z, Liu A, Fang L, Wu F, Hong J, Shi Y, Leung S, Dong C, Zhang JZ
    Immunity, 2011;35(2):273-84.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  152. Contribution of IL-17-producing gamma delta T cells to the efficacy of anticancer chemotherapy.
    Authors: Ma Y, Aymeric L, Locher C, Mattarollo SR, Delahaye NF, Pereira P, Boucontet L, Apetoh L, Ghiringhelli F, Casares N, Lasarte JJ, Matsuzaki G, Ikuta K, Ryffel B, Benlagha K, Tesniere A, Ibrahim N, Dechanet-Merville J, Chaput N, Smyth MJ, Kroemer G, Zitvogel L
    J. Exp. Med., 2011;208(3):491-503.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  153. Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation.
    Authors: Jones GW, Stumhofer JS, Foster T, Twohig JP, Hertzog P, Topley N, Williams AS, Hunter CA, Jenkins BJ, Wang EC, Jones SA
    FASEB J., 2011;25(1):409-19.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  154. Aryl hydrocarbon receptor deficiency in T cells suppresses the development of collagen-induced arthritis.
    Authors: Nakahama T, Kimura A, Nguyen NT, Chinen I, Hanieh H, Nohara K, Fujii-Kuriyama Y, Kishimoto T
    Proc. Natl. Acad. Sci. U.S.A., 2011;108(34):14222-7.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  155. The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF.
    Authors: El-Behi M, Ciric B, Dai H
    Nat. Immunol., 2011;12(6):568-75.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  156. Regulation of the IL-21 gene by the NF-kappaB transcription factor c-Rel.
    Authors: Chen G, Hardy K, Bunting K
    J. Immunol., 2010;185(4):2350-9.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  157. Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus.
    Authors: Kayamuro H, Yoshioka Y, Abe Y, Arita S, Katayama K, Nomura T, Yoshikawa T, Kubota-Koketsu R, Ikuta K, Okamoto S, Mori Y, Kunisawa J, Kiyono H, Itoh N, Nagano K, Kamada H, Tsutsumi Y, Tsunoda S
    J. Virol., 2010;84(24):12703-12.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  158. Antigen-specific Th9 cells exhibit uniqueness in their kinetics of cytokine production and short retention at the inflammatory site.
    Authors: Tan C, Aziz MK, Lovaas JD, Vistica BP, Shi G, Wawrousek EF, Gery I
    J. Immunol., 2010;185(11):6795-801.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  159. Loss of CD4+ T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells.
    Authors: Jones GW, McLoughlin RM, Hammond VJ, Parker CR, Williams JD, Malhotra R, Scheller J, Williams AS, Rose-John S, Topley N, Jones SA
    J. Immunol., 2010;184(4):2130-9.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  160. Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model.
    Authors: Yoshizaki A, Yanaba K, Iwata Y
    J. Immunol., 2010;185(4):2502-15.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  161. TIM-3: a novel regulatory molecule of alloimmune activation.
    Authors: Boenisch O, D'Addio F, Watanabe T, Elyaman W, Magee CN, Yeung MY, Padera RF, Rodig SJ, Murayama T, Tanaka K, Yuan X, Ueno T, Jurisch A, Mfarrej B, Akiba H, Yagita H, Najafian N
    J. Immunol., 2010;185(10):5806-19.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  162. The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells.
    Authors: Dienz O, Eaton SM, Bond JP, Neveu W, Moquin D, Noubade R, Briso EM, Charland C, Leonard WJ, Ciliberto G, Teuscher C, Haynes L, Rincon M
    J. Exp. Med., 2009;206(1):69-78.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  163. Disruption of interleukin-1 signaling improves the quality of wound healing.
    Authors: Thomay AA, Daley JM, Sabo E, Worth PJ, Shelton LJ, Harty MW, Reichner JS, Albina JE
    Am. J. Pathol., 2009;174(6):2129-36.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  164. IL-6 loss causes ventricular dysfunction, fibrosis, reduced capillary density, and dramatically alters the cell populations of the developing and adult heart.
    Authors: Banerjee I, Fuseler JW, Intwala AR, Baudino TA
    Am. J. Physiol. Heart Circ. Physiol., 2009;296(5):H1694-704.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  165. The role of interleukin-6 in lipopolysaccharide-induced fever by mechanisms independent of prostaglandin E2.
    Authors: Nilsberth C, Elander L, Hamzic N, Norell M, Lonn J, Engstrom L, Blomqvist A
    Endocrinology, 2009;150(4):1850-60.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  166. ST2 deficient mice display a normal host defense against pulmonary infection with Mycobacterium tuberculosis.
    Authors: Wieland CW, van der Windt GJ, Florquin S, McKenzie AN, van der Poll T
    Microbes Infect., 2009;11(4):524-30.
  167. Stratification is the key: inflammatory biomarkers accurately direct immunomodulatory therapy in experimental sepsis.
    Authors: Osuchowski MF, Connett J, Welch K, Granger J, Remick DG
    Crit. Care Med., 2009;37(5):1567-73.
    Species: N/A
    Sample Types: N/A
    Applications: ELISA Standard
  168. Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors.
    Authors: Ghiringhelli F, Apetoh L, Tesniere A, Aymeric L, Ma Y, Ortiz C, Vermaelen K, Panaretakis T, Mignot G, Ullrich E, Perfettini JL, Schlemmer F, Tasdemir E, Uhl M, Genin P, Civas A, Ryffel B, Kanellopoulos J, Tschopp J, Andre F, Lidereau R, McLaughlin NM, Haynes NM, Smyth MJ, Kroemer G, Zitvogel L
    Nat. Med., 2009;15(10):1170-8.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  169. Externalization of the leaderless cytokine IL-1F6 occurs in response to lipopolysaccharide/ATP activation of transduced bone marrow macrophages.
    Authors: Martin U, Scholler J, Gurgel J, Renshaw B, Sims JE, Gabel CA
    J. Immunol., 2009;183(6):4021-30.
    Species: Mouse
    Sample Types: Buffer
    Applications: WB Ctrl
  170. Thymic regulation of autoimmune disease by accelerated differentiation of Foxp3+ regulatory T cells through IL-7 signaling pathway.
    Authors: Chen X, Fang L, Song S, Guo TB, Liu A, Zhang JZ
    J. Immunol., 2009;183(10):6135-44.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  171. Role of Tim-3/galectin-9 inhibitory interaction in viral-induced immunopathology: shifting the balance toward regulators.
    Authors: Sehrawat S, Suryawanshi A, Hirashima M, Rouse BT
    J. Immunol., 2009;182(5):3191-201.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  172. GP130-STAT3 regulates epithelial cell migration and is required for repair of the bronchiolar epithelium.
    Authors: Kida H, Mucenski ML, Thitoff AR, Le Cras TD, Park KS, Ikegami M, Muller W, Whitsett JA
    Am. J. Pathol., 2008;172(6):1542-54.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  173. Sphingosine 1-phosphate regulates the egress of IgA plasmablasts from Peyer's patches for intestinal IgA responses.
    Authors: Gohda M, Kunisawa J, Miura F, Kagiyama Y, Kurashima Y, Higuchi M, Ishikawa I, Ogahara I, Kiyono H
    J. Immunol., 2008;180(8):5335-43.
  174. The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice.
    Authors: Guo B, Chang EY, Cheng G
    J. Clin. Invest., 2008;118(5):1680-90.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  175. TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice.
    Authors: McKinley L, Alcorn JF, Peterson A, Dupont RB, Kapadia S, Logar A, Henry A, Irvin CG, Piganelli JD, Ray A, Kolls JK
    J. Immunol., 2008;181(6):4089-97.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  176. A potential role of thymic stromal lymphopoietin in the recruitment of macrophages to mouse intervertebral disc cells via monocyte chemotactic protein 1 induction: implications for herniated discs.
    Authors: Ohba T, Haro H, Ando T, Koyama K, Hatsushika K, Suenaga F, Ohnuma Y, Nakamura Y, Katoh R, Ogawa H, Hamada Y, Nakao A
    Arthritis Rheum., 2008;58(11):3510-9.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  177. CD14 contributes to pulmonary inflammation and mortality during murine tuberculosis.
    Authors: Wieland CW, van der Windt GJ, Wiersinga WJ, Florquin S, van der Poll T
    Immunology, 2008;125(2):272-9.
    Species: N/A
    Sample Types: N/A
    Applications: ELISA Standard
  178. Engagement of the type I interferon receptor on dendritic cells inhibits T helper 17 cell development: role of intracellular osteopontin.
    Authors: Shinohara ML, Kim JH, Garcia VA, Cantor H
    Immunity, 2008;29(1):68-78.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  179. Adiponectin blocks multiple signaling cascades associated with leptin-induced cell proliferation in Apc Min/+ colon epithelial cells.
    Authors: Fenton JI, Birmingham JM, Hursting SD, Hord NG
    Int. J. Cancer, 2008;122(11):2437-45.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  180. Tumor-specific Th17-polarized cells eradicate large established melanoma.
    Authors: Muranski P, Boni A, Antony PA, Cassard L, Irvine KR, Kaiser A, Paulos CM, Palmer DC, Touloukian CE, Ptak K, Gattinoni L, Wrzesinski C, Hinrichs CS, Kerstann KW, Feigenbaum L, Chan CC, Restifo NP
    Blood, 2008;112(2):362-73.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  181. Both Th1 and Th17 are immunopathogenic but differ in other key biological activities.
    Authors: Cox CA, Shi G, Yin H, Vistica BP, Wawrousek EF, Chan CC, Gery I
    J. Immunol., 2008;180(11):7414-22.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  182. TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology.
    Authors: McGeachy MJ, Bak-Jensen KS, Chen Y, Tato CM, Blumenschein W, McClanahan T, Cua DJ
    Nat. Immunol., 2007;8(12):1390-7.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  183. High pressure promotes monocyte adhesion to the vascular wall.
    Authors: Riou S, Mees B, Esposito B, Merval R, Vilar J, Stengel D, Ninio E, van Haperen R, de Crom R, Tedgui A, Lehoux S
    Circ. Res., 2007;100(8):1226-33.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  184. Effect of chronic IL-6 infusion on acute pressor responses to vasoconstrictors in mice.
    Authors: Boesen EI, Pollock DM
    Am. J. Physiol. Heart Circ. Physiol., 2007;293(3):H1745-9.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  185. Local stimulation of the adenosine A2B receptors induces an increased release of IL-6 in mouse striatum: an in vivo microdialysis study.
    Authors: Vazquez JF, Clement HW, Sommer O, Schulz E, van Calker D
    J. Neurochem., 2007;105(3):904-9.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  186. Interleukin-6 as a mechanism for the adverse effects of social stress on acute Theiler's virus infection.
    Authors: Meagher MW, Johnson RR, Young EE, Vichaya EG, Lunt S, Hardin EA, Connor MA, Welsh CJ
    Brain Behav. Immun., 2007;21(8):1083-95.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  187. Induction of a distinct CD8 Tnc17 subset by transforming growth factor-beta and interleukin-6.
    Authors: Liu SJ, Tsai JP, Shen CR, Sher YP, Hsieh CL, Yeh YC, Chou AH, Chang SR, Hsiao KN, Yu FW, Chen HW
    J. Leukoc. Biol., 2007;82(2):354-60.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  188. Inactivated Sendai virus particles eradicate tumors by inducing immune responses through blocking regulatory T cells.
    Authors: Kurooka M, Kaneda Y
    Cancer Res., 2007;67(1):227-36.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  189. IL-17B and IL-17C are associated with TNF-alpha production and contribute to the exacerbation of inflammatory arthritis.
    Authors: Yamaguchi Y, Fujio K, Shoda H, Okamoto A, Tsuno NH, Takahashi K, Yamamoto K
    J. Immunol., 2007;179(10):7128-36.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  190. Osteoblasts support B-lymphocyte commitment and differentiation from hematopoietic stem cells.
    Authors: Zhu J, Garrett R, Jung Y, Zhang Y, Kim N, Wang J, Joe GJ, Hexner E, Choi Y, Taichman RS, Emerson SG
    Blood, 2007;109(9):3706-12.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  191. Maternal immune activation alters fetal brain development through interleukin-6.
    Authors: Smith SE, Li J, Garbett K, Mirnics K, Patterson PH
    J. Neurosci., 2007;27(40):10695-702.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  192. Somatic activation of a conditional KrasG12D allele causes ineffective erythropoiesis in vivo.
    Authors: Braun BS, Archard JA, Van Ziffle JA, Tuveson DA, Jacks TE, Shannon K
    Blood, 2006;108(6):2041-4.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  193. Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality.
    Authors: Osuchowski MF, Welch K, Siddiqui J, Remick DG
    J. Immunol., 2006;177(3):1967-74.
    Species: N/A
    Sample Types: N/A
    Applications: ELISA Standard
  194. Adenoviral-mediated overexpression of SOCS3 enhances IgG immune complex-induced acute lung injury.
    Authors: Gao H, Hoesel LM, Guo RF, Rancilio NJ, Sarma JV, Ward PA
    J. Immunol., 2006;177(1):612-20.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  195. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells.
    Authors: Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, Weiner HL, Kuchroo VK
    Nature, 2006;441(7090):235-8.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  196. The pulmonary and hepatic immune microenvironment and its contribution to the early systemic inflammation following blunt chest trauma.
    Authors: Perl M, Gebhard F, Braumuller S, Tauchmann B, Bruckner UB, Kinzl L, Knoferl MW
    Crit. Care Med., 2006;34(4):1152-9.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  197. Glechoma hederacea inhibits inflammatory mediator release in IFN-gamma and LPS-stimulated mouse peritoneal macrophages.
    Authors: An HJ, Jeong HJ, Um JY, Kim HM, Hong SH
    J Ethnopharmacol, 2006;106(3):418-24.
    Species: N/A
    Sample Types: N/A
    Applications: ELISA Standard
  198. Role of interleukin-6 in cardiomyocyte/cardiac fibroblast interactions during myocyte hypertrophy and fibroblast proliferation.
    Authors: Fredj S, Bescond J, Louault C, Delwail A, Potreau D
    J. Cell. Physiol., 2005;204(2):428-36.
    Species: N/A
    Sample Types: N/A
    Applications: ELISA Standard
  199. Sequential ELISA to profile multiple cytokines from small volumes.
    Authors: Osuchowski MF, Siddiqui J, Copeland S, Remick DG
    J. Immunol. Methods, 2005;302(1):172-81.
    Species: N/A
    Sample Types: N/A
    Applications: ELISA Standard
  200. Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload.
    Authors: Niederkofler V, Salie R, Arber S
    J. Clin. Invest., 2005;115(8):2180-6.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  201. Pivotal role of endogenous tachykinins and the NK1 receptor in mediating leukocyte accumulation, in the absence of oedema formation, in response to TNFalpha in the cutaneous microvasculature.
    Authors: Costa SK, Yshii LM, Poston RN, Muscara MN, Brain SD
    J. Neuroimmunol., 2005;171(1):99-109.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  202. SLAM family markers are conserved among hematopoietic stem cells from old and reconstituted mice and markedly increase their purity.
    Authors: Yilmaz OH, Kiel MJ, Morrison SJ
    Blood, 2005;107(3):924-30.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  203. CXCR2-/- mice show enhanced susceptibility to herpetic stromal keratitis: a role for IL-6-induced neovascularization.
    Authors: Banerjee K, Biswas PS, Kim B, Lee S, Rouse BT
    J. Immunol., 2004;172(2):1237-45.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  204. Cardiotrophin-1 in choroid plexus and the cerebrospinal fluid circulatory system.
    Authors: Gard AL, Gavin E, Solodushko V, Pennica D
    Neuroscience, 2004;127(1):43-52.
    Species: N/A
    Sample Types: N/A
    Applications: WB Ctrl
  205. Selective macrophage suppression during sepsis.
    Authors: Ellaban E, Bolgos G, Remick D
    Cell. Immunol., 2004;231(1):103-11.
    Species: N/A
    Sample Types: N/A
    Applications: ELISA Standard
  206. The IL-6 family cytokines, interleukin-6, interleukin-11, oncostatin M, and leukemia inhibitory factor, enhance mast cell growth through fibroblast-dependent pathway in mice.
    Authors: Gyotoku E, Morita E, Kameyoshi Y, Hiragun T, Yamamoto S, Hide M
    Arch. Dermatol. Res., 2001;293(10):508-14.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  207. Interleukin-6 and the granulocyte colony-stimulating factor receptor are major independent regulators of granulopoiesis in vivo but are not required for lineage commitment or terminal differentiation.
    Authors: Liu F, Poursine-Laurent J, Wu HY, Link DC
    Blood, 1997;90(7):2583-90.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo

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Reviews for Recombinant Mouse IL-6 Protein

Average Rating: 3.7 (Based on 3 Reviews)

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Recombinant Mouse IL-6 Protein
By Anonymous on 02/09/2018
Application: Binding assay/Protein-protein interaction
Reason for Rating: Binding observed by Sirukumab

Recombinant Mouse IL-6 Protein
By Anonymous on 08/03/2016
Application: Stem/Immune cell maintenance or differentiation

Recombinant Mouse IL-6 Protein
By Anonymous on 05/17/2016
Application: Binding assay/Protein-protein interaction