Recombinant Mouse TGF-beta 1 Protein

(85 citations)
(2 Reviews)
  
  • Purity
    >95%, by SDS-PAGE under reducing conditions and visualized by silver stain
  • Endotoxin Level
    <0.01 EU per 1 μg of the protein by the LAL method.
  • Activity
    Measured by its ability to inhibit the IL-4-dependent proliferation of HT‑2 mouse T cells. Tsang, M. et al. (1995) Cytokine 7:389. The ED50 for this effect is 0.04-0.2 ng/mL.
  • Source
    Chinese Hamster Ovary cell line, CHO-derived Ala279-Ser390
  • Accession #
  • N-terminal Sequence
    Analysis
    Ala279
  • Structure / Form
    Disulfide-linked homodimer
  • Predicted Molecular Mass
    12.8 kDa (monomer)
  • SDS-PAGE
    10.5 kDa, reducing conditions
Carrier Free
What does CF mean?
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
What formulation is right for me?
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
7666-MB
 
7666-MB/CF
Formulation Lyophilized from a 0.2 μm filtered solution in HCl with BSA as a carrier protein.
Formulation Lyophilized from a 0.2 μm filtered solution in HCl.
Reconstitution Reconstitute at 50 μg/mL in 4 mM HCl containing at least 0.1% human or bovine serum albumin.
Reconstitution Reconstitute at 50 μg/mL in 4 mM HCl.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: TGF-beta 1

TGF-beta 1 (transforming growth factor beta 1) is one of three closely related mammalian members of the large TGF‑ beta superfamily that share a characteristic cystine knot structure (1‑7). TGF‑ beta 1, -2 and -3 are highly pleiotropic cytokines that are proposed to act as cellular switches that regulate processes such as immune function, proliferation and epithelial‑mesenchymal transition (1‑4). Each TGF‑ beta isoform has some non‑redundant functions; for TGF‑ beta 1, mice with targeted deletion show defects in hematopoiesis and endothelial differentiation, and die of overwhelming inflammation (2). Human or mouse TGF‑ beta 1 cDNA encodes a 390 amino acid (aa) precursor that contains a 29 aa signal peptide and a 361 aa proprotein (8). A furin‑like convertase processes the proprotein to generate an N‑terminal 249 aa latency‑associated peptide (LAP) and a C‑terminal 112 aa mature TGF‑ beta 1 (8, 9). Disulfide‑linked homodimers of LAP and TGF‑ beta 1 remain non‑covalently associated after secretion, forming the small latent TGF‑ beta 1 complex (8‑10). Covalent linkage of LAP to one of three latent TGF‑ beta binding proteins (LTBPs) creates a large latent complex that may interact with the extracellular matrix (9, 10). TGF‑ beta is activated from latency by pathways that include actions of the protease plasmin, matrix metalloproteases, thrombospondin 1 and a subset of integrins (10). Mature mouse TGF‑ beta 1 shares 99‑100% aa sequence identity with human, rat, equine, porcine, canine and bovine TGF‑ beta 1. It demonstrates cross‑species activity (1). TGF‑ beta 1 signaling begins with high‑affinity binding to a type II ser/thr kinase receptor termed TGF‑ beta  RII. This receptor then phosphorylates and activates a second ser/thr kinase receptor, TGF‑ beta  RI (also called activin receptor‑like kinase (ALK) ‑5), or alternatively, ALK‑1. This complex phosphorylates and activates Smad proteins that regulate transcription (3, 11, 12). Contributions of the accessory receptors betaglycan (also known as TGF‑ beta  RIII) and endoglin, or use of Smad‑independent signaling pathways, allow for disparate actions observed in response to TGF‑ beta in different contexts (11).

  • References:
    1. Derynck, R. and K. Miyazono (2008) Cold Spring Harbor Laboratory Press, 29.
    2. Dunker, N. and K. Krieglstein (2000) Eur. J. Biochem. 267:6982.
    3. Wahl, S.M. (2006) Immunol. Rev. 213:213.
    4. Chang, H. et al. (2002) Endocr. Rev. 23:787.
    5. Lin, J.S. et al. (2006) Reproduction 132:179.
    6. Hinck, A.P. et al. (1996) Biochemistry 35:8517.
    7. Mittl, P.R.E. et al. (1996) Protein Sci. 5:1261.
    8. Derynck, R. et al. (1985) Nature 316:701.
    9. Miyazono, K. et al. (1988) J. Biol. Chem. 263:6407.
    10. Oklu, R. and R. Hesketh (2000) Biochem. J. 352:601.
    11. de Caestecker, M. et al. (2004) Cytokine Growth Factor Rev. 15:1.
    12. Zuniga, J.E. et al. (2005) J. Mol. Biol. 354:1052.
  • Long Name:
    Transforming Growth Factor beta 1
  • Entrez Gene IDs:
    7040 (Human); 21803 (Mouse); 59086 (Rat); 397078 (Porcine); 100033900 (Equine)
  • Alternate Names:
    CEDLAP; DPD1; latency-associated peptide; TGFB; TGFB1; TGF-beta 1 protein; TGFbeta 1; TGF-beta 1; TGFbeta; TGF-beta-1; transforming growth factor beta-1; transforming growth factor, beta 1
Related Research Areas
Citations:

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

85 Citations: Showing 1 - 10
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Species
Applications
Sample Type
  1. Notch Balances Th17 and Induced Regulatory T Cell Functions in Dendritic Cells by Regulating Aldh1a2 Expression
    Authors: TS Zaman, H Arimochi, S Maruyama, C Ishifune, SI Tsukumo, A Kitamura, K Yasutomo
    J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  2. Local Inflammatory Cues Regulate Differentiation and Persistence of CD8(+) Tissue-Resident Memory T Cells
    Authors: T Bergsbaken, MJ Bevan, PJ Fink
    Cell Rep, 2017;19(1):114-124.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  3. Manipulating Glucose Metabolism during Different Stages of Viral Pathogenesis Can Have either Detrimental or Beneficial Effects
    Authors: SK Varanasi, D Donohoe, U Jaggi, BT Rouse
    J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  4. Absence of Notch1 in murine myeloid cells attenuates the development of experimental autoimmune encephalomyelitis by affecting Th1 and Th17 priming
    Authors: M Fernández, EM Monsalve, S López-Lópe, A Ruiz-Garcí, S Mellado, E Caminos, JJ García-Ram, J Laborda, P Tranque, MJM Díaz-Guerr
    Eur. J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  5. Rad52 competes with Ku70/Ku86 for binding to S-region DSB ends to modulate antibody class-switch DNA recombination
    Authors: H Zan, C Tat, Z Qiu, JR Taylor, JA Guerrero, T Shen, P Casali
    Nat Commun, 2017;8(0):14244.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  6. The Kielin/chordin-like Protein (KCP) Attenuates High Fat Diet Induced Obesity and Metabolic Syndrome in Mice
    Authors: A Soofi, KI Wolf, MP Emont, N Qi, G Martinez-S, E Grimley, W Ostwani, GR Dressler
    J. Biol. Chem., 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  7. Lamtor1 Is Critically Required for CD4(+) T Cell Proliferation and Regulatory T Cell Suppressive Function
    Authors: T Hosokawa, T Kimura, S Nada, T Okuno, D Ito, S Kang, S Nojima, K Yamashita, T Nakatani, Y Hayama, Y Kato, Y Kinehara, M Nishide, N Mikami, S Koyama, H Takamatsu, D Okuzaki, N Ohkura, S Sakaguchi, M Okada, A Kumanogoh
    J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  8. Suppressive IL-17A(+)Foxp3(+) and ex-Th17 IL-17A(neg)Foxp3(+) Treg cells are a source of tumour-associated Treg cells
    Authors: S Downs-Cann, S Berkey, GM Delgoffe, RP Edwards, T Curiel, K Odunsi, DL Bartlett, N Obermajer
    Nat Commun, 2017;8(0):14649.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  9. Pirfenidone attenuates bleomycin-induced pulmonary fibrosis in mice by regulating Nrf2/Bach1 equilibrium
    Authors: Y Liu, F Lu, L Kang, Z Wang, Y Wang
    BMC Pulm Med, 2017;17(1):63.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  10. Wolf-Hirschhorn Syndrome Candidate 1 Is Necessary for Correct Hematopoietic and B Cell Development
    Authors: E Campos-San, N Deleyto-Se, V Dominguez, E Carrillo-d, K Ura, PP Rocha, J Kim, A Aljoufi, A Esteve-Cod, M Dabad, M Gut, H Heyn, Y Kaneda, K Nimura, JA Skok, ML Martinez-F, C Cobaleda
    Cell Rep, 2017;19(8):1586-1601.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  11. Inhibiting Oxidative Phosphorylation In Vivo Restrains Th17 Effector Responses and Ameliorates Murine Colitis
    Authors: L Franchi, I Monteleone, LY Hao, MA Spahr, W Zhao, X Liu, K Demock, A Kulkarni, CA Lesch, B Sanchez, L Carter, I Marafini, X Hu, O Mashadova, M Yuan, JM Asara, H Singh, CA Lyssiotis, G Monteleone, AW Opipari, GD Glick
    J. Immunol, 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  12. CYP4A in tumor-associated macrophages promotes pre-metastatic niche formation and metastasis
    Authors: XW Chen, TJ Yu, J Zhang, Y Li, HL Chen, GF Yang, W Yu, YZ Liu, XX Liu, CF Duan, HL Tang, M Qiu, CL Wang, H Zheng, J Yue, AM Guo, J Yang
    Oncogene, 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  13. Inhibition of ubiquitin-specific protease 34 (USP34) induces epithelial-mesenchymal transition and promotes stemness in mammary epithelial cells
    Authors: E Oh, JY Kim, D Sung, Y Cho, N Lee, H An, YJ Kim, TM Cho, JH Seo
    Cell. Signal., 2017;36(0):230-239.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  14. Vimentin coordinates fibroblast proliferation and keratinocyte differentiation in wound healing via TGF-?-Slug signaling
    Proc Natl Acad Sci USA, 2016;113(30):E4320-7.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  15. Treatment of refractory cutaneous ulcers with mixed sheets consisting of peripheral blood mononuclear cells and fibroblasts
    Authors: Koji Ueno
    Sci Rep, 2016;6(0):28538.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  16. Autonomous membrane IgE signaling prevents IgE-memory formation
    Nat Immunol, 2016;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  17. Leptin directly promotes T-cell glycolytic metabolism to drive effector T-cell differentiation in a mouse model of autoimmunity
    Eur J Immunol, 2016;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  18. Affinity for self antigen selects Treg cells with distinct functional properties
    Nat Immunol, 2016;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  19. Alternative splicing of MALT1 controls signalling and activation of CD4(+) T cells
    Authors: I Meininger, RA Griesbach, D Hu, T Gehring, T Seeholzer, A Bertossi, J Kranich, A Oeckinghau, AC Eitelhuber, U Greczmiel, A Gewies, M Schmidt-Su, J Ruland, T Brocker, V Heissmeyer, F Heyd, D Krappmann
    Nat Commun, 2016;7(0):11292.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  20. Reduced TCR-dependent activation through citrullination of a T-cell epitope enhances Th17 development by disruption of the STAT3/5 balance
    Eur J Immunol, 2016;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  21. Th1 cells downregulate connexin 43 gap junctions in astrocytes via microglial activation
    Sci Rep, 2016;6(0):38387.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  22. Differential effects of Pax3 on expression of polysialyltransferases STX and PST in TGF-?-treated normal murine mammary gland cells
    Exp Biol Med (Maywood), 2016;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  23. Restoration of Corneal Transparency by Mesenchymal Stem Cells
    Stem Cell Reports, 2016;7(4):583-590.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  24. T cells are necessary for ILC2 activation in house dust mite-induced allergic airway inflammation in mice
    Authors: BW Li, MJ de Bruijn, I Tindemans, M Lukkes, A KleinJan, HC Hoogsteden, RW Hendriks
    Eur J Immunol, 2016;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  25. Pharmacologic modulation of ROR?t translates to efficacy in preclinical and translational models of psoriasis and inflammatory arthritis
    Sci Rep, 2016;6(0):37977.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  26. All Trans Retinoic Acid, Transforming Growth Factor ? and Prostaglandin E2 in Mouse Plasma Synergize with Basophil-Secreted Interleukin-4 to M2 Polarize Murine Macrophages
    PLoS ONE, 2016;11(12):e0168072.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  27. Beta 1-integrin ligation and TLR ligation enhance GM-CSF-induced ALDH1A2 expression in dendritic cells, but differentially regulate their anti-inflammatory properties
    Sci Rep, 2016;6(0):37914.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  28. Long non-coding RNAs (LncRNA) regulated by transforming growth factor (TGF) beta: LncRNA-hit-mediated TGFbeta-induced epithelial to mesenchymal transition in mammary epithelia.
    Authors: Richards E, Zhang G, Li Z, Permuth-Wey J, Challa S, Li Y, Kong W, Dan S, Bui M, Coppola D, Mao W, Sellers T, Cheng J
    J Biol Chem, 2015;290(11):6857-67.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  29. miR-148a is upregulated by Twist1 and T-bet and promotes Th1-cell survival by regulating the proapoptotic gene Bim.
    Authors: Haftmann C, Stittrich A, Zimmermann J, Fang Z, Hradilkova K, Bardua M, Westendorf K, Heinz G, Riedel R, Siede J, Lehmann K, Weinberger E, Zimmel D, Lauer U, Haupl T, Sieper J, Backhaus M, Neumann C, Hoffmann U, Porstner M, Chen W, Grun J, Baumgrass R, Matz M, Lohning M, Scheffold A, Wittmann J, Chang H, Rajewsky N, Jack H, Radbruch A, Mashreghi M
    Eur J Immunol, 2015;45(4):1192-205.
    Species: Mouse
    Sample Type: Cell Culture Treatment
    Application: Bioassay
  30. Testosterone suppresses hepatic inflammation by the downregulation of IL-17, CXCL-9, and CXCL-10 in a mouse model of experimental acute cholangitis.
    Authors: Schwinge D, Carambia A, Quaas A, Krech T, Wegscheid C, Tiegs G, Prinz I, Lohse A, Herkel J, Schramm C
    J Immunol, 2015;194(6):2522-30.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  31. Mesenchymal stem/stromal cells protect against autoimmunity via CCL2-dependent recruitment of myeloid-derived suppressor cells.
    Authors: Lee H, Ko J, Jeong H, Ko A, Kim M, Wee W, Yoon S, Oh J
    J Immunol, 2015;194(8):3634-45.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  32. Retinoic acid can exacerbate T cell intrinsic TLR2 activation to promote tolerance.
    Authors: Nguyen, Vivien, Pearson, Kandyce, Kim, Jee-Hyun, Kamdar, Karishma, DePaolo, R Willia
    PLoS ONE, 2015;10(3):e0118875.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  33. Blocking follistatin-like 1 attenuates bleomycin-induced pulmonary fibrosis in mice.
    Authors: Dong Y, Geng Y, Li L, Li X, Yan X, Fang Y, Li X, Dong S, Liu X, Li X, Yang X, Zheng X, Xie T, Liang J, Dai H, Liu X, Yin Z, Noble P, Jiang D, Ning W
    J Exp Med, 2015;212(2):235-52.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  34. Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros-derived hematopoietic stem cells.
    Authors: Hadland B, Varnum-Finney B, Poulos M, Moon R, Butler J, Rafii S, Bernstein I
    J Clin Invest, 2015;125(5):2032-45.
    Species: Mouse
    Sample Type: protein
    Application: Bioassay
  35. IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iTreg cell balance.
    Authors: Basu R, Whitley S, Bhaumik S, Zindl C, Schoeb T, Benveniste E, Pear W, Hatton R, Weaver C
    Nat Immunol, 2015;16(3):286-95.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  36. ShcA regulates late stages of T cell development and peripheral CD4+ T cell numbers.
    Authors: Buckley M, Trampont P, Arandjelovic S, Fond A, Juncadella I, Ravichandran K
    J Immunol, 2015;194(4):1665-76.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  37. Novel mechanism of macrophage-mediated metastasis revealed in a zebrafish model of tumor development.
    Authors: Wang J, Cao Z, Zhang X, Nakamura M, Sun M, Hartman J, Harris R, Sun Y, Cao Y
    Cancer Res, 2015;75(2):306-15.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  38. A functional polymorphism of Ptpn22 is associated with type 1 diabetes in the BioBreeding rat.
    Authors: Sarmiento J, Wallis R, Ning T, Marandi L, Chao G, Veillette A, Lernmark A, Paterson A, Poussier P
    J Immunol, 2015;194(2):615-29.
    Species: Rat
    Sample Type: Whole Cells
    Application: Bioassay
  39. Dendritic cell SIRT1-HIF1alpha axis programs the differentiation of CD4+ T cells through IL-12 and TGF-beta1.
    Authors: Liu G, Bi Y, Xue L, Zhang Y, Yang H, Chen X, Lu Y, Zhang Z, Liu H, Wang X, Wang R, Chu Y, Yang R
    Proc Natl Acad Sci U S A, 2015;112(9):E957-65.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  40. Itk signals promote neuroinflammation by regulating CD4+ T-cell activation and trafficking.
    Authors: Kannan A, Kim D, August A, Bynoe M
    J Neurosci, 2015;35(1):221-33.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  41. Impaired dendritic cell function in a spontaneous autoimmune polyneuropathy.
    Authors: Quan S, Kim H, Dukala D, Sheng J, Soliven B
    J Immunol, 2015;194(9):4175-84.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  42. Myocardin-related transcription factors control the motility of epicardium-derived cells and the maturation of coronary vessels.
    Authors: Trembley M, Velasquez L, de Mesy Bentley K, Small E
    Development, 2015;142(1):21-30.
  43. Regulatory T cell reprogramming toward a Th2-cell-like lineage impairs oral tolerance and promotes food allergy.
    Authors: Noval Rivas M, Burton O, Wise P, Charbonnier L, Georgiev P, Oettgen H, Rachid R, Chatila T
    Immunity, 2015;42(3):512-23.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  44. Beclin 1 regulates neuronal transforming growth factor-beta signaling by mediating recycling of the type I receptor ALK5.
    Authors: O'Brien C, Bonanno L, Zhang H, Wyss-Coray T
    Mol Neurodegener, 2015;10(1):69.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  45. Monocyte Chemoattractant Protein-Induced Protein 1 (MCPIP1) Enhances Angiogenic and Cardiomyogenic Potential of Murine Bone Marrow-Derived Mesenchymal Stem Cells.
    Authors: Labedz-Maslowska A, Lipert B, Berdecka D, Kedracka-Krok S, Jankowska U, Kamycka E, Sekula M, Madeja Z, Dawn B, Jura J, Zuba-Surma E
    PLoS ONE, 2015;10(7):e0133746.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  46. The hippo pathway effector Yap controls patterning and differentiation of airway epithelial progenitors.
    Authors: Mahoney J, Mori M, Szymaniak A, Varelas X, Cardoso W
    Dev Cell, 2014;30(2):137-50.
    Species: Mouse
    Sample Type: Whole Tissue
    Application: Bioassay
  47. Matrix metalloproteinase-9 deficiency attenuates diabetic nephropathy by modulation of podocyte functions and dedifferentiation.
    Authors: Li S, Huang P, Yang A, Tarng D, Yang W, Lin C, Chen J, Schmid-Schonbein G, Lin S
    Kidney Int, 2014;86(2):358-69.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  48. Alternative splice variants of AID are not stoichiometrically present at the protein level in chronic lymphocytic leukemia.
    Authors: Rebhandl S, Huemer M, Zaborsky N, Gassner F, Catakovic K, Felder T, Greil R, Geisberger R
    Eur J Immunol, 2014;44(7):2175-87.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  49. The alarmin IL-33 promotes regulatory T-cell function in the intestine.
    Authors: Schiering C, Krausgruber T, Chomka A, Frohlich A, Adelmann K, Wohlfert E, Pott J, Griseri T, Bollrath J, Hegazy A, Harrison O, Owens B, Lohning M, Belkaid Y, Fallon P, Powrie F
    Nature, 2014;513(7519):564-8.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  50. Attenuation of experimental colitis in glutathione peroxidase 1 and catalase double knockout mice through enhancing regulatory T cell function.
    Authors: Kim H, Lee A, Choi E, Kie J, Lim W, Lee H, Moon B, Seoh J
    PLoS ONE, 2014;9(4):e95332.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  51. Unexpected phenotype of mice lacking Shcbp1, a protein induced during T cell proliferation.
    Authors: Buckley M, Arandjelovic S, Trampont P, Kim T, Braciale T, Ravichandran K
    PLoS ONE, 2014;9(8):e105576.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  52. Toll-like receptor 9 mediated responses in cardiac fibroblasts.
    Authors: Ohm I, Alfsnes K, Belland Olsen M, Ranheim T, Sandanger O, Dahl T, Aukrust P, Finsen A, Yndestad A, Vinge L
    PLoS ONE, 2014;9(8):e104398.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  53. Lnk/Sh2b3 controls the production and function of dendritic cells and regulates the induction of IFN-gamma-producing T cells.
    Authors: Mori T, Iwasaki Y, Seki Y, Iseki M, Katayama H, Yamamoto K, Takatsu K, Takaki S
    J Immunol, 2014;193(4):1728-36.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  54. Elongated TCR alpha chain CDR3 favors an altered CD4 cytokine profile.
    Authors: Reynolds C, Chong D, Raynsford E, Quigley K, Kelly D, Llewellyn-Hughes J, Altmann D, Boyton R
    BMC Biol, 2014;12(0):32.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  55. Molecular and cellular features of murine craniofacial and trunk neural crest cells as stem cell-like cells.
    Authors: Hagiwara, Kunie, Obayashi, Takeshi, Sakayori, Nobuyuki, Yamanishi, Emiko, Hayashi, Ryuhei, Osumi, Noriko, Nakazawa, Toru, Nishida, Kohji
    PLoS ONE, 2014;9(1):e84072.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  56. Myostatin stimulates, not inihibits, C2C12 myoblast proliferation.
    Authors: Rodgers B, Wiedeback B, Hoversten K, Jackson M, Walker R, Thompson T
    Endocrinology, 2014;155(3):670-5.
    Species: Mouse
    Sample Type: whole cells
    Application: Bioassay
  57. The transcription factor IRF8 activates integrin-mediated TGF-beta signaling and promotes neuroinflammation.
    Authors: Yoshida Y, Yoshimi R, Yoshii H, Kim D, Dey A, Xiong H, Munasinghe J, Yazawa I, O'Donovan M, Maximova O, Sharma S, Zhu J, Wang H, Morse H, Ozato K
    Immunity, 2014;40(2):187-98.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  58. Hepatocytes induce Foxp3(+) regulatory T cells by Notch signaling.
    Authors: Burghardt S, Claass B, Erhardt A, Karimi K, Tiegs G
    J Leukoc Biol, 2014;96(4):571-7.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  59. Siah2 regulates tight junction integrity and cell polarity through control of ASPP2 stability.
    Authors: Kim H, Claps G, Moller A, Bowtell D, Lu X, Ronai Z
    Oncogene, 2014;33(15):2004-10.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  60. Cell-extrinsic CTLA4-mediated regulation of dendritic cell maturation depends on STAT3.
    Authors: Kowalczyk A, D'Souza C, Zhang L
    Eur J Immunol, 2014;44(4):1143-55.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  61. Brain glycolipids suppress T helper cells and inhibit autoimmune demyelination.
    Authors: Mycko M, Sliwinska B, Cichalewska M, Cwiklinska H, Raine C, Selmaj K
    J Neurosci, 2014;34(25):8646-58.
  62. Integrin-mediated type II TGF-beta receptor tyrosine dephosphorylation controls SMAD-dependent profibrotic signaling.
    Authors: Chen X, Wang H, Liao H, Hu W, Gewin L, Mernaugh G, Zhang S, Zhang Z, Vega-Montoto L, Vanacore R, Fassler R, Zent R, Pozzi A
    J Clin Invest, 2014;124(8):3295-310.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  63. Laminin alpha1 regulates age-related mesangial cell proliferation and mesangial matrix accumulation through the TGF-beta pathway.
    Authors: Ning L, Kurihara H, de Vega S, Ichikawa-Tomikawa N, Xu Z, Nonaka R, Kazuno S, Yamada Y, Miner J, Arikawa-Hirasawa E
    Am J Pathol, 2014;184(6):1683-94.
    Species: Mouse
    Sample Type: N/A
    Application: ELISA development
  64. Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment.
    Authors: Seth A, Ye J, Yu N, Guez F, Bedford D, Neale G, Cordi S, Brindle P, Lemaigre F, Kaestner K, Sosa-Pineda B
    Development, 2014;141(3):538-47.
    Species: Mouse
    Sample Type: Whole Tissue
    Application: Bioassay
  65. Retinoic acid prevents mesenteric lymph node dendritic cells from inducing IL-13-producing inflammatory Th2 cells.
    Authors: Yokota-Nakatsuma A, Takeuchi H, Ohoka Y, Kato C, Song S, Hoshino T, Yagita H, Ohteki T, Iwata M
    Mucosal Immunol, 2014;7(4):786-801.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  66. Blockade of IL-33 release and suppression of type 2 innate lymphoid cell responses by helminth secreted products in airway allergy.
    Authors: McSorley H, Blair N, Smith K, McKenzie A, Maizels R
    Mucosal Immunol, 2014;7(5):1068-78.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  67. IL-21 induces IL-22 production in CD4+ T cells.
    Authors: Yeste A, Mascanfroni I, Nadeau M, Burns E, Tukpah A, Santiago A, Wu C, Patel B, Kumar D, Quintana F
    Nat Commun, 2014;5(0):3753.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  68. A Snail1/Notch1 signalling axis controls embryonic vascular development.
    Authors: Wu Z, Rowe R, Lim K, Lin Y, Willis A, Tang Y, Li X, Nor J, Maillard I, Weiss S
    Nat Commun, 2014;5(0):3998.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  69. HIV Nef expression favors the relative preservation of CD4+ T regulatory cells that retain some important suppressive functions.
    Authors: Chrobak P, Afkhami S, Priceputu E, Poudrier J, Meunier C, Hanna Z, Sparwasser T, Jolicoeur P
    J Immunol, 2014;192(4):1681-92.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  70. Real-time imaging of the epithelial-mesenchymal transition using microRNA-200a sequence-based molecular beacon-conjugated magnetic nanoparticles.
    Authors: Choi Y, Kim H, Woo J, Hwang E, Cho K, Kim S, Moon W
    PLoS ONE, 2014;9(7):e102164.
    Species: Canine
    Sample Type: Whole Cells
    Application: Bioassay
  71. TGF-beta and opioid receptor signaling crosstalk results in improvement of endogenous and exogenous opioid analgesia under pathological pain conditions.
    Authors: Lantero A, Tramullas M, Pilar-Cuellar F, Valdizan E, Santillan R, Roques B, Hurle M
    J Neurosci, 2014;34(15):5385-95.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  72. Tracking the elusive fibrocyte: identification and characterization of collagen-producing hematopoietic lineage cells during murine wound healing.
    Authors: Suga H, Rennert R, Rodrigues M, Sorkin M, Glotzbach J, Januszyk M, Fujiwara T, Longaker M, Gurtner G
    Stem Cells, 2014;32(5):1347-60.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  73. Thrombospondin-1 induction in the diabetic myocardium stabilizes the cardiac matrix in addition to promoting vascular rarefaction through angiopoietin-2 upregulation.
    Authors: Gonzalez-Quesada C, Cavalera M, Biernacka A, Kong P, Lee D, Saxena A, Frunza O, Dobaczewski M, Shinde A, Frangogiannis N
    Circ Res, 2013;113(12):1331-44.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  74. The loss of Trps1 suppresses ureteric bud branching because of the activation of TGF-beta signaling.
    Authors: Gui T, Sun Y, Gai Z, Shimokado A, Muragaki Y, Zhou G
    Dev Biol, 2013;377(2):415-27.
    Species: Mouse
    Sample Type: Whole Tissue
    Application: Bioassay
  75. FAK-related nonkinase is a multifunctional negative regulator of pulmonary fibrosis.
    Authors: Ding Q, Cai G, Hu M, Yang Y, Zheng A, Tang Q, Gladson C, Hayasaka H, Wu H, You Z, Southern B, Grove L, Rahaman S, Fang H, Olman M
    Am J Pathol, 2013;182(5):1572-84.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  76. Exposure to atmospheric particulate matter enhances Th17 polarization through the aryl hydrocarbon receptor.
    Authors: van Voorhis, Michael, Knopp, Samantha, Julliard, Walker, Fechner, John H, Zhang, Xiaoji, Schauer, James J, Mezrich, Joshua D
    PLoS ONE, 2013;8(12):e82545.
    Species: Mouse
    Sample Type: whole cells
    Application: cell culture
  77. Endothelial dysfunction exacerbates renal interstitial fibrosis through enhancing fibroblast Smad3 linker phosphorylation in the mouse obstructed kidney.
    Authors: Sun Y, Qu X, Li X, Nikolic-Paterson D, Li J
    PLoS ONE, 2013;8(12):e84063.
    Species: Rat
    Sample Type: whole cells
    Application: cell culture
  78. TNF-alpha promotes cerebral pericyte remodeling in vitro, via a switch from alpha1 to alpha2 integrins.
    Authors: Tigges U, Boroujerdi A, Welser-Alves J, Milner R
    J Neuroinflammation, 2013;10(0):33.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  79. Integration of multiple signaling regulates through apoptosis the differential osteogenic potential of neural crest-derived and mesoderm-derived Osteoblasts.
    Authors: Li S, Meyer N, Quarto N, Longaker M
    PLoS ONE, 2013;8(3):e58610.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  80. Distinctive subdomains in the resorbing surface of osteoclasts.
    Authors: Szewczyk K, Fuller K, Chambers T
    PLoS ONE, 2013;8(3):e60285.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  81. Interferon gamma suppresses collagen-induced arthritis by regulation of Th17 through the induction of indoleamine-2,3-deoxygenase.
    Authors: Lee J, Lee J, Park M, Lim M, Park E, Kim E, Yang E, Lee S, Jhun J, Park S, Kim H, Cho M
    PLoS ONE, 2013;8(4):e60900.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  82. IL-4/IL-13-dependent and independent expression of miR-124 and its contribution to M2 phenotype of monocytic cells in normal conditions and during allergic inflammation.
    Authors: Veremeyko, Tatyana, Siddiqui, Shafiudd, Sotnikov, Ilya, Yung, Amanda, Ponomarev, Eugene D
    PLoS ONE, 2013;8(12):e81774.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  83. Activation of PPAR-alpha induces cell cycle arrest and inhibits transforming growth factor-beta1 induction of smooth muscle cell phenotype in 10T1/2 mesenchymal cells.
    Authors: Lien S, Wei S, Chang S, Chang M, Chang J, Chiu J
    Cell Signal, 2013;25(5):1252-63.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  84. Control of T helper 2 responses by transcription factor IRF4-dependent dendritic cells.
    Authors: Gao Y, Nish S, Jiang R, Hou L, Licona-Limon P, Weinstein J, Zhao H, Medzhitov R
    Immunity, 2013;39(4):722-32.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  85. Regulation of innate CD8+ T-cell activation mediated by cytokines.
    Proc Natl Acad Sci U S A, 2012;109(25):9971-6.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
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Average Rating: 5 (Based on 2 reviews)

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