Recombinant Mouse TGF-beta 1 Protein

Carrier Free

Catalog # Availability Size / Price Qty
7666-MB-005/CF

With Carrier

Catalog # Availability Size / Price Qty
7666-MB-005
Graph showing dose-dependent bioactivity of mouse TGF-beta 1 protein
1 Image
Product Details
Citations (214)
FAQs
Reviews (12)

Recombinant Mouse TGF-beta 1 Protein Summary

Product Specifications

Purity
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Level
<0.01 EU per 1 μg of the protein by the LAL method.
Activity
Measured by its ability to inhibit the IL-4-dependent proliferation of HT‑2 mouse T cells. Tsang, M. et al. (1995) Cytokine 7:389. The ED50 for this effect is 0.04-0.2 ng/mL.
Source
Chinese Hamster Ovary cell line, CHO-derived mouse TGF-beta 1 protein
Ala279-Ser390
Accession #
N-terminal Sequence
Analysis
Ala279
Structure / Form
Disulfide-linked homodimer
Predicted Molecular Mass
12.8 kDa (monomer)
SDS-PAGE
10.5 kDa, reducing conditions

Product Datasheets

7666-MB (with carrier)

7666-MB/CF (carrier free)

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

7666-MB

Formulation Lyophilized from a 0.2 μm filtered solution in HCl with BSA as a carrier protein.
Reconstitution Reconstitute at 50 μg/mL in 4 mM HCl containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

7666-MB/CF

Formulation Lyophilized from a 0.2 μm filtered solution in HCl.
Reconstitution Reconstitute at 50 μg/mL in 4 mM HCl.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Data Image

Bioactivity Bioactivity of Mouse TGF-beta 1 View Larger

Recombinant mouse TGF-beta 1 (7666-MB) inhibits IL-4-dependent proliferation in the HT-2 mouse T cell line. The ED50 for this effect is 0.04-0.2 ng/mL.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: TGF-beta 1

TGF-beta 1 (transforming growth factor beta 1) is one of three closely related mammalian members of the large TGF‑ beta superfamily that share a characteristic cystine knot structure (1‑7). TGF‑ beta 1, -2 and -3 are highly pleiotropic cytokines that are proposed to act as cellular switches that regulate processes such as immune function, proliferation and epithelial‑mesenchymal transition (1‑4). Each TGF‑ beta isoform has some non‑redundant functions; for TGF‑ beta 1, mice with targeted deletion show defects in hematopoiesis and endothelial differentiation, and die of overwhelming inflammation (2). Human or mouse TGF‑ beta 1 cDNA encodes a 390 amino acid (aa) precursor that contains a 29 aa signal peptide and a 361 aa proprotein (8). A furin‑like convertase processes the proprotein to generate an N‑terminal 249 aa latency‑associated peptide (LAP) and a C‑terminal 112 aa mature TGF‑ beta 1 (8, 9). Disulfide‑linked homodimers of LAP and TGF‑ beta 1 remain non‑covalently associated after secretion, forming the small latent TGF‑ beta 1 complex (8‑10). Covalent linkage of LAP to one of three latent TGF‑ beta binding proteins (LTBPs) creates a large latent complex that may interact with the extracellular matrix (9, 10). TGF‑ beta is activated from latency by pathways that include actions of the protease plasmin, matrix metalloproteases, thrombospondin 1 and a subset of integrins (10). Mature mouse TGF‑ beta 1 shares 99‑100% aa sequence identity with human, rat, equine, porcine, canine and bovine TGF‑ beta 1. It demonstrates cross‑species activity (1). TGF‑ beta 1 signaling begins with high‑affinity binding to a type II ser/thr kinase receptor termed TGF‑ beta  RII. This receptor then phosphorylates and activates a second ser/thr kinase receptor, TGF‑ beta  RI (also called activin receptor‑like kinase (ALK) ‑5), or alternatively, ALK‑1. This complex phosphorylates and activates Smad proteins that regulate transcription (3, 11, 12). Contributions of the accessory receptors betaglycan (also known as TGF‑ beta  RIII) and endoglin, or use of Smad‑independent signaling pathways, allow for disparate actions observed in response to TGF‑ beta in different contexts (11).

References
  1. Derynck, R. and K. Miyazono (2008) Cold Spring Harbor Laboratory Press, 29.
  2. Dunker, N. and K. Krieglstein (2000) Eur. J. Biochem. 267:6982.
  3. Wahl, S.M. (2006) Immunol. Rev. 213:213.
  4. Chang, H. et al. (2002) Endocr. Rev. 23:787.
  5. Lin, J.S. et al. (2006) Reproduction 132:179.
  6. Hinck, A.P. et al. (1996) Biochemistry 35:8517.
  7. Mittl, P.R.E. et al. (1996) Protein Sci. 5:1261.
  8. Derynck, R. et al. (1985) Nature 316:701.
  9. Miyazono, K. et al. (1988) J. Biol. Chem. 263:6407.
  10. Oklu, R. and R. Hesketh (2000) Biochem. J. 352:601.
  11. de Caestecker, M. et al. (2004) Cytokine Growth Factor Rev. 15:1.
  12. Zuniga, J.E. et al. (2005) J. Mol. Biol. 354:1052.
Long Name
Transforming Growth Factor beta 1
Entrez Gene IDs
7040 (Human); 21803 (Mouse); 59086 (Rat); 397078 (Porcine); 100033900 (Equine)
Alternate Names
CEDLAP; DPD1; latency-associated peptide; TGF beta; TGF beta1; TGFB; TGFB1; TGF-beta 1 protein; TGFbeta 1; TGF-beta 1; TGFbeta; TGF-beta-1; transforming growth factor beta-1; transforming growth factor, beta 1

Citations for Recombinant Mouse TGF-beta 1 Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

214 Citations: Showing 1 - 10
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  1. Impact of HIV-1 Vpr manipulation of the DNA repair enzyme UNG2 on B lymphocyte class switch recombination
    Authors: P Eldin, S Péron, A Galashevsk, N Denis-Laga, M Cogné, G Slupphaug, L Briant
    J Transl Med, 2020;18(1):310.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  2. Sirt1 antisense long non-coding RNA attenuates pulmonary fibrosis through sirt1-mediated epithelial-mesenchymal transition
    Authors: W Qian, X Cai, Q Qian
    Aging (Albany NY), 2020;12(5):4322-4336.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  3. Differential regulation of Lipocalin 2 (LCN2) in doxorubicin-resistant 4T1 triple negative breast cancer cells
    Authors: SK Meurer, O Tezcan, T Lammers, R Weiskirche
    Cell. Signal., 2020;74(0):109731.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  4. Macrophages directly contribute collagen to scar formation during zebrafish heart regeneration and mouse heart repair
    Authors: FC Simões, TJ Cahill, A Kenyon, D Gavriouchk, JM Vieira, X Sun, D Pezzolla, C Ravaud, E Masmanian, M Weinberger, S Mayes, ME Lemieux, DN Barnette, M Gunadasa-R, RM Williams, DR Greaves, LA Trinh, SE Fraser, SL Dallas, RP Choudhury, T Sauka-Spen, PR Riley
    Nat Commun, 2020;11(1):600.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  5. Functional Radiogenetic Profiling Implicates ERCC6L2 in Non-homologous End Joining
    Authors: P Francica, M Mutlu, VA Blomen, C Oliveira, Z Nowicka, A Trenner, NM Gerhards, P Bouwman, E Stickel, ML Hekkelman, L Lingg, I Klebic, M van de Ven, R de Korte-G, D Howald, J Jonkers, AA Sartori, W Fendler, JR Chapman, T Brummelkam, S Rottenberg
    Cell Rep, 2020;32(8):108068.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  6. Identification of the growth factor binding sequence in the extracellular matrix protein MAGP-1
    Authors: TJ Broekelman, NK Bodmer, RP Mecham
    J. Biol. Chem., 2020;0(0):.
    Species: N/A
    Sample Types: Protein
    Applications: Surface Plasmon Resonance
  7. Neurokinin-1 Receptor Signaling Is Required for Efficient Ca2+ Flux in T-Cell-Receptor-Activated T Cells
    Authors: AE Morelli, TL Sumpter, DM Rojas-Cana, M Bandyopadh, Z Chen, O Tkacheva, WJ Shufesky, CT Wallace, SC Watkins, A Berger, CJ Paige, LD Falo, AT Larregina
    Cell Rep, 2020;30(10):3448-3465.e8.
    Species: Mouse
    Sample Types: Dendritic Cells
    Applications: Bioassay
  8. LRR domain of NLRX1 protein delivery by dNP2 inhibits T cell functions and alleviates autoimmune encephalomyelitis
    Authors: JH Koo, DH Kim, D Cha, MJ Kang, JM Choi
    Theranostics, 2020;10(7):3138-3150.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  9. N-Acetyldopamine derivatives from Periostracum Cicadae and their regulatory activities on Th1 and Th17 cell differentiation
    Authors: P Thapa, Y Gu, YS Kil, SC Baek, KH Kim, AR Han, EK Seo, H Choi, JH Chang, JW Nam
    Bioorg. Chem., 2020;102(0):104095.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  10. NOX4 Inhibition Potentiates Immunotherapy by Overcoming Cancer-Associated Fibroblast-Mediated CD8 T-cell Exclusion from Tumors
    Authors: K Ford, CJ Hanley, M Mellone, C Szyndralew, F Heitz, P Wiesel, O Wood, M Machado, MA Lopez, AP Ganesan, C Wang, A Chakravart, TR Fenton, EV King, P Vijayanand, CH Ottensmeie, A Al-Shamkha, N Savelyeva, GJ Thomas
    Cancer Res., 2020;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  11. NFAT-Specific Inhibition by dNP2-VIVITAmeliorates Autoimmune Encephalomyelitisby Regulation of Th1 and Th17
    Authors: HG Lee, LK Kim, JM Choi
    Mol Ther Methods Clin Dev, 2020;16(0):32-41.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  12. Methylation in pericytes after acute injury promotes chronic kidney disease
    Authors: YH Chou, SY Pan, YH Shao, HM Shih, SY Wei, CF Lai, WC Chiang, C Schrimpf, KC Yang, LC Lai, YM Chen, TS Chu, SL Lin
    J. Clin. Invest., 2020;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  13. Osteoprotegerin is More than a Possible Serum Marker in Liver Fibrosis: A Study into its Function in Human and Murine Liver
    Authors: A Adhyatmika, L Beljaars, KSS Putri, H Habibie, CE Boorsma, C Reker-Smit, T Luangmonko, B Guney, A Haak, KA Mangnus, E Post, K Poelstra, K Ravnskjaer, P Olinga, BN Melgert
    Pharmaceutics, 2020;12(5):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Tissue Culture
  14. Novel AXL-specific inhibitor ameliorates kidney dysfunction through the inhibition of epithelial-to-mesenchymal transition of renal tubular cells
    Authors: A Kurata, Y Tachibana, T Takahashi, N Horiba
    PLoS ONE, 2020;15(4):e0232055.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Cell Culture
  15. Oral therapy with colonization factor antigen I prevents development of type 1 diabetes in Non-obese Diabetic mice
    Authors: AS Nelson, M Maddaloni, JR Abbott, C Hoffman, A Akgul, C Ohland, RZ Gharaibeh, C Jobin, TM Brusko, DW Pascual
    Sci Rep, 2020;10(1):6156.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: ELISA Standard
  16. B cell Sirt1 deacetylates histone and non-histone proteins for epigenetic modulation of AID expression and the antibody response
    Authors: H Gan, T Shen, DP Chupp, JR Taylor, HN Sanchez, X Li, Z Xu, H Zan, P Casali
    Sci Adv, 2020;6(14):eaay2793.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  17. Myeloid cell-derived TGF-beta signaling regulates ECM deposition in mammary carcinoma via adenosine-dependent mechanisms
    Authors: G Vasiukov, T Novitskaya, A Zijlstra, P Owens, F Ye, Z Zhao, HL Moses, T Blackwell, I Feoktistov, SV Novitskiy
    Cancer Res., 2020;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  18. TLR9 Sensing of Self-DNA Controls Cell-Mediated Immunity to Listeria Infection via Rapid Conversion of Conventional CD4+ T Cells to Treg
    Authors: JS Dolina, J Lee, RQ Griswold, L Labarta-Ba, S Kannan, JA Greenbaum, N Bahia El I, MJ Pont, M Croft, SP Schoenberg
    Cell Rep, 2020;31(1):107249.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  19. Conditional deletion of Nedd4-2 in lung epithelial cells causes progressive pulmonary fibrosis in adult mice
    Authors: J Duerr, DHW Leitz, M Szczygiel, D Dvornikov, SG Fraumann, C Kreutz, PK Zadora, A Seyhan Agi, P Konietzke, TA Engelmann, J Hegermann, S Mulugeta, H Kawabe, L Knudsen, M Ochs, D Rotin, T Muley, M Kreuter, FJF Herth, MO Wielpütz, MF Beers, U Klingmülle, MA Mall
    Nat Commun, 2020;11(1):2012.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  20. TGF&beta suppresses CD8+ T cell expression of CXCR3 and tumor trafficking
    Authors: AJ Gunderson, T Yamazaki, K McCarty, N Fox, M Phillips, A Alice, T Blair, M Whiteford, D O'Brien, R Ahmad, MX Kiely, A Hayman, T Crocenzi, MJ Gough, MR Crittenden, KH Young
    Nat Commun, 2020;11(1):1749.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  21. Effects of senataxin and RNA exosome on B-cell chromosomal integrity
    Authors: D Kazadi, J Lim, G Rothschild, V Grinstein, B Laffleur, O Becherel, MJ Lavin, U Basu
    Heliyon, 2020;6(3):e03442.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  22. Different Regulation of Glut1 Expression and Glucose Uptake during the Induction and Chronic Stages of TGF&beta1-Induced EMT in Breast Cancer Cells
    Authors: A Nilchian, N Giotopoulo, W Sun, J Fuxe
    Biomolecules, 2020;10(12):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  23. PPAR&beta/&delta-dependent MSC metabolism determines their immunoregulatory properties
    Authors: RA Contreras-, R Elizondo-V, MJ Torres, AM Vega-Lette, N Luque-Camp, MJ Paredes-Ma, C Pradenas, G Tejedor, K Oyarce, M Salgado, C Jorgensen, M Khoury, G Kronke, MA Garcia-Rob, C Altamirano, P Luz-Crawfo, F Djouad
    Sci Rep, 2020;10(1):11423.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  24. Canonical and noncanonical TGF-&beta signaling regulate fibrous tissue differentiation in the axial skeleton
    Authors: SW Clayton, GI Ban, C Liu, R Serra
    Scientific Reports, 2020;10(1):21364.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  25. Estrogen receptor ? in T cells suppresses follicular helper T cell responses and prevents autoimmunity
    Authors: DH Kim, HJ Park, HS Park, JU Lee, C Ko, MC Gye, JM Choi
    Exp. Mol. Med., 2019;51(4):41.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  26. Blocking interleukin-6 trans-signaling protects against renal fibrosis by suppressing STAT3 activation
    Authors: W Chen, H Yuan, W Cao, T Wang, W Chen, H Yu, Y Fu, B Jiang, H Zhou, H Guo, X Zhao
    Theranostics, 2019;9(14):3980-3991.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  27. TGFbeta-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis
    Authors: J Li, A Ayoub, Y Xiu, X Yin, JO Sanders, A Mesfin, L Xing, Z Yao, BF Boyce
    Nat Commun, 2019;10(1):2795.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  28. Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation
    Authors: AA Lombardi, AA Gibb, E Arif, DW Kolmetzky, D Tomar, TS Luongo, P Jadiya, EK Murray, PK Lorkiewicz, G Hajnóczky, E Murphy, ZP Arany, DP Kelly, KB Margulies, BG Hill, JW Elrod
    Nat Commun, 2019;10(1):4509.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  29. Fibulin-1c regulates transforming growth factor-beta activation in pulmonary tissue fibrosis
    Authors: G Liu, MA Cooley, AG Jarnicki, T Borghuis, PM Nair, G Tjin, AC Hsu, TJ Haw, M Fricker, CL Harrison, B Jones, NG Hansbro, PA Wark, JC Horvat, WS Argraves, BG Oliver, DA Knight, JK Burgess, PM Hansbro
    JCI Insight, 2019;5(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  30. Does co-transplantation of mesenchymal and spermatogonial stem cells improve reproductive efficiency and safety in mice?
    Authors: P Kadam, E Ntemou, J Onofre, D Van Saen, E Goossens
    Stem Cell Res Ther, 2019;10(1):310.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  31. Cutting Edge: ATM Influences Germinal Center Integrity
    Authors: L Nicolas, M Cols, R Smolkin, KC Fernandez, WT Yewdell, WF Yen, S Zha, BQ Vuong, J Chaudhuri
    J. Immunol., 2019;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  32. Salvia miltiorrhiza and Carthamus tinctorius Extract Prevents Cardiac Fibrosis and Dysfunction after Myocardial Infarction by Epigenetically Inhibiting Smad3 Expression
    Authors: J Yang, B Wang, N Li, Q Zhou, W Zhou, Z Zhan
    Evid Based Complement Alternat Med, 2019;2019(0):6479136.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  33. Pharmacological inhibition of ?-catenin/BCL9 interaction overcomes resistance to immune checkpoint blockades by modulating Treg cells
    Authors: M Feng, JQ Jin, L Xia, T Xiao, S Mei, X Wang, X Huang, J Chen, M Liu, C Chen, S Rafi, AX Zhu, YX Feng, D Zhu
    Sci Adv, 2019;5(5):eaau5240.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  34. Activation of aryl hydrocarbon receptor signaling by a novel agonist ameliorates autoimmune encephalomyelitis
    Authors: A Abdullah, M Maged, I Hairul-Isl, A Osama I, H Maha, A Manal, H Hamza
    PLoS ONE, 2019;14(4):e0215981.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  35. Oral flavonoid fisetin treatment protects against prolonged high-fat-diet-induced cardiac dysfunction by regulation of multicombined signaling
    Authors: LF Hu, J Feng, X Dai, Y Sun, M Xiong, L Lai, S Zhong, C Yi, G Chen, H Li, Q Yang, Q Kuang, T Long, J Zhan, T Tang, C Ge, J Tan, M Xu
    J. Nutr. Biochem., 2019;77(0):108253.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  36. Foxp1 is critical for the maintenance of regulatory T-cell homeostasis and suppressive function
    Authors: J Ren, L Han, J Tang, Y Liu, X Deng, Q Liu, P Hao, X Feng, B Li, H Hu, H Wang
    PLoS Biol., 2019;17(5):e3000270.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  37. Identification of a pro-angiogenic functional role for FSP1-positive fibroblast subtype in wound healing
    Authors: S Saraswati, SMW Marrow, LA Watch, PP Young
    Nat Commun, 2019;10(1):3027.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  38. Enhanced glycolytic metabolism supports transmigration of brain-infiltrating macrophages in multiple sclerosis
    Authors: DK Kaushik, A Bhattachar, R Mirzaei, KS Rawji, Y Ahn, JM Rho, VW Yong
    J. Clin. Invest., 2019;130(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  39. Ablation of RhoA impairs Th17 cell differentiation and alleviates house dust mite-triggered allergic airway inflammation
    Authors: JQ Yang, KW Kalim, Y Li, Y Zheng, F Guo
    J. Leukoc. Biol., 2019;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  40. Label-free quantitative proteomics identifies transforming growth factorβ1 (TGF-?1) as an inhibitor of adipogenic transformation in OP9-DL1 cells and primary thymic stromal cells
    Authors: J Tan, Y Wang, S Wang, S Wu, Z Yuan, X Zhu
    Cell Biosci, 2019;9(0):48.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ChIP
  41. 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine derivatives as inhibitors of full-length RORγt
    Authors: C Lao, X Zhou, H Chen, F Wei, Z Huang, C Bai
    Bioorg. Chem., 2019;90(0):103077.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  42. Pirfenidone prevents and reverses hepatic insulin resistance and steatohepatitis by polarizing M2 macrophages
    Authors: G Chen, Y Ni, N Nagata, L Xu, F Zhuge, M Nagashimad, S Kaneko, T Ota
    Lab. Invest., 2019;0(0):.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  43. Salvia miltiorrhiza and Carthamus tinctorius Extract Prevents Cardiac Fibrosis and Dysfunction after Myocardial Infarction by Epigenetically Inhibiting Smad3 Expression
    Authors: J Yang, B Wang, N Li, Q Zhou, W Zhou, Z Zhan
    Evid Based Complement Alternat Med, 2019;2019(0):6479136.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  44. Gas6 Prevents Epithelial-Mesenchymal Transition in Alveolar Epithelial Cells via Production of PGE2, PGD2 and Their Receptors
    Authors: J Jung, YJ Lee, YH Choi, EM Park, HS Kim, JL Kang
    Cells, 2019;8(7):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  45. Impact of aging on transition of acute kidney injury to chronic kidney disease
    Authors: MG Kim, J Yang, YS Ko, HY Lee, SW Oh, WY Cho, SK Jo
    Sci Rep, 2019;9(1):18445.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  46. Inhibition of Rho-Kinase Downregulates Th17 Cells and Ameliorates Hepatic Fibrosis by Schistosoma japonicum Infection
    Authors: W Zhou, Y Yang, C Mei, P Dong, S Mu, H Wu, Y Zhou, Y Zheng, F Guo, JQ Yang
    Cells, 2019;8(10):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  47. The Tec kinase ITK is essential for ILC2 survival and epithelial integrity in the intestine
    Authors: HS Cho, A Reboldi, JA Hall, LJ Berg
    Nat Commun, 2019;10(1):784.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  48. miRNA profiling of urinary exosomes to assess the progression of acute kidney injury
    Authors: H Sonoda, BR Lee, KH Park, D Nihalani, JH Yoon, M Ikeda, SH Kwon
    Sci Rep, 2019;9(1):4692.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  49. Resolution of Cutaneous Leishmaniasis and Persistence of Leishmania major in the Absence of Arginase 1
    Authors: K Paduch, A Debus, B Rai, U Schleicher, C Bogdan
    J. Immunol., 2019;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  50. Inhibins regulate peripheral regulatory T cell induction through modulation of dendritic cell function
    Authors: M de la Fuen, R Olguín-Alo, S Ortega-Fra, LC Bonifaz, G Soldevila
    FEBS Open Bio, 2019;9(1):137-147.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  51. MYMD-1, a Novel Immunometabolic Regulator, Ameliorates Autoimmune Thyroiditis via Suppression of Th1 Responses and TNF-? Release
    Authors: G Di Dalmazi, P Chalan, P Caturegli
    J. Immunol., 2019;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  52. Targeting of dermal myofibroblasts through death receptor 5 arrests fibrosis in mouse models of scleroderma
    Authors: JS Park, Y Oh, YJ Park, O Park, H Yang, S Slania, LK Hummers, AA Shah, HT An, J Jang, MR Horton, J Shin, HC Dietz, E Song, DH Na, EJ Park, K Kim, KC Lee, VV Roschke, J Hanes, MG Pomper, S Lee
    Nat Commun, 2019;10(1):1128.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  53. Pathogenic function of bystander-activated memory-like CD4+ T cells in autoimmune encephalomyelitis
    Authors: HG Lee, JU Lee, DH Kim, S Lim, I Kang, JM Choi
    Nat Commun, 2019;10(1):709.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  54. Tangeretin attenuates lipopolysaccharide-induced acute lung injury through Notch signaling pathway via suppressing Th17?cell response in mice
    Authors: M Li, Y Zhao, D Qi, J He, D Wang
    Microb. Pathog., 2019;138(0):103826.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  55. DGAT1 inhibits retinol-dependent regulatory T cell formation and mediates autoimmune encephalomyelitis
    Authors: KL Graham, BJ Werner, KM Moyer, AK Patton, CR Krois, HS Yoo, M Tverskoy, M LaJevic, JL Napoli, RA Sobel, BA Zabel, EC Butcher
    Proc. Natl. Acad. Sci. U.S.A., 2019;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  56. Microglia are an essential component of the neuroprotective scar that forms after spinal cord injury
    Authors: V Bellver-La, F Bretheau, B Mailhot, N Vallières, M Lessard, ME Janelle, N Vernoux, MÈ Tremblay, T Fuehrmann, MS Shoichet, S Lacroix
    Nat Commun, 2019;10(1):518.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  57. Putative endothelial progenitor cells do not promote vascular repair but attenuate pericyte-myofibroblast transition in UUO-induced renal fibrosis
    Authors: J Yang, M Wang, F Zhu, J Sun, H Xu, OL Chong Lee, Z Zhao, G Pei, H Zhu, C Cao, X He, Y Huang, Z Ma, L Liu, L Wang, Y Ning, W Liu, G Xu, X Wang, R Zeng, Y Yao
    Stem Cell Res Ther, 2019;10(1):104.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  58. Hedgehog Interacting Protein Promotes Fibrosis and Apoptosis in Glomerular Endothelial Cells in Murine Diabetes
    Authors: XP Zhao, SY Chang, MC Liao, CS Lo, I Chenier, H Luo, JL Chiasson, JR Ingelfinge, JSD Chan, SL Zhang
    Sci Rep, 2018;8(1):5958.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  59. DW2008S and its major constituents from Justicia procumbens exert anti-asthmatic effect via multitargeting activity
    Authors: J Youm, H Lee, Y Choi, J Yoon
    J. Cell. Mol. Med., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  60. Cross-Inhibition of Norrin and TGF-? Signaling Modulates Development of Retinal and Choroidal Vasculature
    Authors: R Seitz, G Weber, S Albrecht, R Fuchshofer, ER Tamm, A Ohlmann
    Invest. Ophthalmol. Vis. Sci., 2018;59(6):2240-2251.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  61. Mesenchymal stem cells ameliorate experimental arthritis via expression of interleukin-1 receptor antagonist
    Authors: K Lee, N Park, H Jung, YA Rim, Y Nam, J Lee, SH Park, JH Ju
    PLoS ONE, 2018;13(2):e0193086.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  62. Interferon-gamma inhibits seminal plasma induction of colony stimulating factor 2 in mouse and human reproductive tract epithelial cells
    Authors: DJ Sharkey, DJ Glynn, JE Schjenken, KP Tremellen, SA Robertson
    Biol. Reprod., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  63. Rab4b Deficiency in T Cells Promotes Adipose Treg/Th17 Imbalance, Adipose Tissue Dysfunction, and Insulin Resistance
    Authors: J Gilleron, G Bouget, S Ivanov, C Meziat, F Ceppo, B Vergoni, M Djedaini, A Soprani, K Dumas, A Jacquel, L Yvan-Charv, N Venteclef, JF Tanti, M Cormont
    Cell Rep, 2018;25(12):3329-3341.e5.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  64. Characterization and allergic role of IL-33-induced neutrophil polarization
    Authors: B Sun, L Zhu, Y Tao, HX Sun, Y Li, P Wang, Y Hou, Y Zhao, X Zhang, L Zhang, N Na, Y Zhao
    Cell. Mol. Immunol., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  65. Intraperitoneal infusion of mesenchymal stem cell attenuates severity of collagen antibody induced arthritis
    Authors: Y Nam, SM Jung, YA Rim, H Jung, K Lee, N Park, J Kim, Y Jang, YB Park, SH Park, JH Ju
    PLoS ONE, 2018;13(6):e0198740.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  66. Differential Phagocytic Properties of CD45lowMicroglia and CD45highBrain Mononuclear Phagocytes-Activation and Age-Related Effects
    Authors: S Rangaraju, SA Raza, NX Li, R Betarbet, EB Dammer, D Duong, JJ Lah, NT Seyfried, AI Levey
    Front Immunol, 2018;9(0):405.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  67. TGF-?-Induced CD8CD103Regulatory T Cells Show Potent Therapeutic Effect on Chronic Graft-versus-Host Disease Lupus by Suppressing B Cells
    Authors: H Zhong, Y Liu, Z Xu, P Liang, H Yang, X Zhang, J Zhao, J Chen, S Fu, Y Tang, J Lv, J Wang, N Olsen, A Xu, SG Zheng
    Front Immunol, 2018;9(0):35.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  68. Hexokinase II may be dispensable for CD4 T cell responses against a virus infection
    Authors: SK Varanasi, U Jaggi, N Hay, BT Rouse
    PLoS ONE, 2018;13(1):e0191533.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  69. RAGE Deletion Confers Renoprotection by Reducing Responsiveness to Transforming Growth Factor-? and Increasing Resistance to Apoptosis
    Authors: S Hagiwara, K Sourris, M Ziemann, W Tieqiao, M Mohan, AD McClelland, E Brennan, J Forbes, M Coughlan, B Harcourt, S Penfold, B Wang, G Higgins, R Pickering, A El-Osta, MC Thomas, ME Cooper, P Kantharidi
    Diabetes, 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  70. Fatty acid synthase is required for profibrotic TGF-? signaling
    Authors: MY Jung, JH Kang, DM Hernandez, X Yin, M Andrianifa, Y Wang, A Gonzalez-G, AH Limper, R Lupu, EB Leof
    FASEB J., 2018;0(0):fj201701187R.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  71. Fas Promotes T Helper 17 Cell Differentiation and Inhibits T Helper 1 Cell Development by Binding and Sequestering Transcription Factor STAT1
    Authors: G Meyer Zu H, D Przybylski, MA Schramm, C Wang, A Schnell, Y Lee, R Sobel, A Regev, VK Kuchroo
    Immunity, 2018;48(3):556-569.e7.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  72. Collagen-derived peptides modulate CD4T-cell differentiation and suppress allergic responses in mice
    Authors: A Nishikimi, YI Koyama, S Ishihara, S Kobayashi, C Tometsuka, M Kusubata, K Kuwaba, O Hayashida, S Hattori, K Katagiri
    Immun Inflamm Dis, 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  73. ILDR2-Fc Is a Novel Regulator of Immune Homeostasis and Inducer of Antigen-Specific Immune Tolerance
    Authors: JR Podojil, I Hecht, MY Chiang, I Vaknin, I Barbiro, A Novik, E Neria, G Rotman, SD Miller
    J. Immunol., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  74. Transforming growth factor-?1 up-regulates connexin43 expression in osteocytes via canonical Smad-dependent signaling pathway
    Authors: W Liu, Y Cui, J Sun, L Cai, J Xie, X Zhou
    Biosci. Rep., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  75. Celastrol mediates Th17 and Treg cell generation via metabolic signaling
    Authors: J Zhang, J Shan, X Chen, S Li, D Long, Y Li
    Biochem. Biophys. Res. Commun., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  76. Comparing Effects of Transforming Growth Factor ?1 on Microglia From Rat and Mouse: Transcriptional Profiles and Potassium Channels
    Authors: S Lively, D Lam, R Wong, LC Schlichter
    Front Cell Neurosci, 2018;12(0):115.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  77. Reduced production of laminin by hepatic stellate cells contributes to impairment in oval cell response to liver injury in aged mice
    Authors: L Qian, H Zhang, Y Gu, D Li, S He, H Wang, Y Cheng, W Yang, H Yu, X Zhao, W Cai, L Meng, M Jin, Y Wang, Y Zhang
    Aging (Albany NY), 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  78. Leukotriene B4 promotes neovascularization and macrophage recruitment in murine wet-type AMD models
    Authors: F Sasaki, T Koga, M Ohba, K Saeki, T Okuno, K Ishikawa, T Nakama, S Nakao, S Yoshida, T Ishibashi, H Ahmadieh, MR Kanavi, A Hafezi-Mog, JM Penninger, KH Sonoda, T Yokomizo
    JCI Insight, 2018;3(18):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  79. Microbiota-driven interleukin-17-producing cells and eosinophils synergize to accelerate multiple myeloma progression
    Authors: A Calcinotto, A Brevi, M Chesi, R Ferrarese, L Garcia Per, M Grioni, S Kumar, VM Garbitt, ME Sharik, KJ Henderson, G Tonon, M Tomura, Y Miwa, E Esplugues, RA Flavell, S Huber, F Canducci, VS Rajkumar, PL Bergsagel, M Bellone
    Nat Commun, 2018;9(1):4832.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  80. Attenuation of pulmonary fibrosis in type I collagen-targeted reporter mice with ALK-5 inhibitors
    Authors: H Terashima, M Aonuma, H Tsuchida, K Sugimoto, M Yokoyama, M Kato
    Pulm Pharmacol Ther, 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  81. GLK-IKK? signaling induces dimerization and translocation of the AhR-ROR?t complex in IL-17A induction and autoimmune disease
    Authors: HC Chuang, CY Tsai, CH Hsueh, TH Tan
    Sci Adv, 2018;4(9):eaat5401.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  82. The shieldin complex mediates 53BP1-dependent DNA repair
    Authors: SM Noordermee, S Adam, D Setiaputra, M Barazas, SJ Pettitt, AK Ling, M Olivieri, A Álvarez-Qu, N Moatti, M Zimmermann, S Annunziato, DB Krastev, F Song, I Brandsma, J Frankum, R Brough, A Sherker, S Landry, RK Szilard, MM Munro, A McEwan, T Goullet de, ZY Lin, T Hart, J Moffat, AC Gingras, A Martin, H van Attiku, J Jonkers, CJ Lord, S Rottenberg, D Durocher
    Nature, 2018;560(7716):117-121.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  83. Co-transplantation of mesenchymal stem cells improves spermatogonial stem cell transplantation efficiency in mice
    Authors: P Kadam, E Ntemou, Y Baert, S Van Laere, D Van Saen, E Goossens
    Stem Cell Res Ther, 2018;9(1):317.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  84. The H2B deubiquitinase Usp22 promotes antibody class switch recombination by facilitating non-homologous end joining
    Authors: C Li, T Irrazabal, CC So, M Berru, L Du, E Lam, AK Ling, JL Gommerman, Q Pan-Hammar, A Martin
    Nat Commun, 2018;9(1):1006.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  85. OX40 Costimulation Inhibits Foxp3 Expression and Treg Induction via BATF3-Dependent and Independent Mechanisms
    Authors: X Zhang, X Xiao, P Lan, J Li, Y Dou, W Chen, N Ishii, S Chen, B Xia, K Chen, E Taparowsky, XC Li
    Cell Rep, 2018;24(3):607-618.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  86. Notch ligand Delta-like 4 induces epigenetic regulation of Treg cell differentiation and function in viral infection
    Authors: HA Ting, D de Almeida, AJ Rasky, CA Malinczak, IP Maillard, MA Schaller, NW Lukacs
    Mucosal Immunol, 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  87. DNA double-strand break response factors influence end-joining features of IgH class switch and general translocation junctions
    Authors: RA Panchaksha, X Zhang, V Kumar, Z Du, PC Wei, J Kao, J Dong, FW Alt
    Proc. Natl. Acad. Sci. U.S.A., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  88. Transcription factor scleraxis vitally contributes to progenitor lineage direction in wound healing of adult tendon in mice
    Authors: T Sakabe, K Sakai, T Maeda, A Sunaga, N Furuta, R Schweitzer, T Sasaki, T Sakai
    J. Biol. Chem., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  89. Galectin-9 is Critical for Mucosal Adaptive Immunity through the TH17-IgA Axis
    Authors: CC Liang, CS Li, IC Weng, HY Chen, HH Lu, CC Huang, FT Liu
    Am. J. Pathol., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  90. Lung fibroblasts express a miR-19a-19b-20a sub-cluster to suppress TGF-?-associated fibroblast activation in murine pulmonary fibrosis
    Authors: K Souma, S Shichino, S Hashimoto, S Ueha, T Tsukui, T Nakajima, HI Suzuki, FHW Shand, Y Inagaki, T Nagase, K Matsushima
    Sci Rep, 2018;8(1):16642.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  91. TRPV4 regulates matrix stiffness and TGF?1-induced epithelial-mesenchymal transition
    Authors: S Sharma, R Goswami, DX Zhang, SO Rahaman
    J. Cell. Mol. Med., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  92. Tumor-Induced Generation of Splenic Erythroblast-like Ter-Cells Promotes Tumor Progression
    Authors: Y Han, Q Liu, J Hou, Y Gu, Y Zhang, Z Chen, J Fan, W Zhou, S Qiu, Y Zhang, T Dong, N Li, Z Jiang, H Zhu, Q Zhang, Y Ma, L Zhang, Q Wang, Y Yu, N Li, X Cao
    Cell, 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  93. Neer Award 2018: Platelet-derived growth factor receptor α co-expression typifies a subset of platelet-derived growth factor receptor β-positive progenitor cells that contribute to fatty degeneration and fibrosis of the murine rotator cuff
    Authors: AR Jensen, BV Kelley, GM Mosich, A Ariniello, CD Eliasberg, B Vu, P Shah, SK Devana, IR Murray, B Péault, A Dar, FA Petriglian
    J Shoulder Elbow Surg, 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  94. Elevated extracellular calcium ions promote proliferation and migration of mesenchymal stem cells via increasing osteopontin expression
    Authors: MN Lee, HS Hwang, SH Oh, A Roshanzade, JW Kim, JH Song, ES Kim, JT Koh
    Exp. Mol. Med., 2018;50(11):142.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  95. IL-23 restoration of Th17 effector function is independent of IL-6 and TGF-? in a mouse model of alcohol and burn injury
    Authors: X Li, AR Cannon, AM Hammer, NL Morris, MA Choudhry
    J. Leukoc. Biol., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  96. The excretory-secretory products of Echinococcus granulosus protoscoleces directly regulate the differentiation of B10, B17 and Th17 cells
    Authors: W Pan, WT Hao, YJ Shen, XY Li, YJ Wang, FF Sun, JH Yin, J Zhang, RX Tang, JP Cao, KY Zheng
    Parasit Vectors, 2017;10(1):348.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  97. Follistatin like-1 (Fstl1) is required for the normal formation of lung airway and vascular smooth muscle at birth
    Authors: X Liu, Y Liu, X Li, J Zhao, Y Geng, W Ning
    PLoS ONE, 2017;12(6):e0177899.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  98. Manipulating Glucose Metabolism during Different Stages of Viral Pathogenesis Can Have either Detrimental or Beneficial Effects
    Authors: SK Varanasi, D Donohoe, U Jaggi, BT Rouse
    J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  99. Pirfenidone attenuates bleomycin-induced pulmonary fibrosis in mice by regulating Nrf2/Bach1 equilibrium
    Authors: Y Liu, F Lu, L Kang, Z Wang, Y Wang
    BMC Pulm Med, 2017;17(1):63.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  100. The long non-coding RNA GAS5 regulates TGF-?-induced smooth muscle cell differentiation via RNA-Smad binding element
    Authors: R Tang, G Zhang, YC Wang, X Mei, SY Chen
    J. Biol. Chem., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  101. CD73 promotes resistance to HER2/ErbB2 antibody therapy
    Authors: M Turcotte, D Allard, D Mittal, Y Bareche, L Buisseret, V Jose, S Pommey, V Delisle, S Loi, H Joensuu, PL Kellokumpu, C Sotiriou, MJ Smyth, J Stagg
    Cancer Res., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  102. Inhibiting Oxidative Phosphorylation In Vivo Restrains Th17 Effector Responses and Ameliorates Murine Colitis
    Authors: L Franchi, I Monteleone, LY Hao, MA Spahr, W Zhao, X Liu, K Demock, A Kulkarni, CA Lesch, B Sanchez, L Carter, I Marafini, X Hu, O Mashadova, M Yuan, JM Asara, H Singh, CA Lyssiotis, G Monteleone, AW Opipari, GD Glick
    J. Immunol, 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  103. Interleukin-17A-promoted MSC2 polarization related with new bone formation of ankylosing spondylitis
    Authors: T He, Y Huang, C Zhang, D Liu, C Cheng, W Xu, X Zhang
    Oncotarget, 2017;8(57):96993-97008.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  104. Absence of Notch1 in murine myeloid cells attenuates the development of experimental autoimmune encephalomyelitis by affecting Th1 and Th17 priming
    Authors: M Fernández, EM Monsalve, S López-Lópe, A Ruiz-Garcí, S Mellado, E Caminos, JJ García-Ram, J Laborda, P Tranque, MJM Díaz-Guerr
    Eur. J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  105. BJ-1108, a 6-Amino-2,4,5-trimethylpyridin-3-ol analogue, regulates differentiation of Th1 and Th17 cells to ameliorate experimental autoimmune encephalomyelitis
    Authors: Y Kang, M Timilshina, TG Nam, BS Jeong, JH Chang
    Biol. Res, 2017;50(1):8.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  106. Balanced Bcl-3 expression in murine CD4(+) T cells is required for generation of encephalitogenic Th17 cells
    Authors: IA Mufazalov, J Kuschmann, D Andruszews, J Masri, LA Gabriel, P Adams, S Reissig, N Hövelmeyer, A Waisman
    Eur. J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  107. BJ-2266 ameliorates experimental autoimmune encephalomyelitis through down-regulation of the JAK/STAT signaling pathway
    Authors: Z You, M Timilshina, BS Jeong, JH Chang
    Eur. J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  108. Interleukin 4 receptor-targeted pro-apoptotic peptide blocks tumor growth and metastasis by enhancing anti-tumor immunity
    Authors: SMP Vadevoo, JE Kim, GR Gunassekar, HK Jung, L Chi, DE Kim, SH Lee, SH Im, B Lee
    Mol. Cancer Ther., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  109. Estrogen modulates mesenchymal-epidermal interactions in the adult nipple
    Authors: HJ Wu, JW Oh, DF Spandau, S Tholpady, J Diaz, LJ Schroeder, CD Offutt, AB Glick, MV Plikus, S Koyama, J Foley
    Development, 2017;0(0):.
    Species: Mouse
    Sample Types: Complex Sample Type
    Applications: In Vivo
  110. Selective degradation of PU.1 during autophagy represses the differentiation and antitumour activity of TH9 cells
    Authors: T Rivera Var, Z Cai, Y Shen, M Dosset, I Benoit-Liz, T Martin, A Roussey, RA Flavell, F Ghiringhel, L Apetoh
    Nat Commun, 2017;8(1):559.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  111. Signaling via Smad2 and Smad3 is dispensable for adult murine hematopoietic stem cell function in vivo
    Authors: M Billing, E Rörby, M Dahl, U Blank, S Andradottí, MM Matzuk, M Ehinger, S Karlsson
    Exp. Hematol., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  112. Mechanosignaling activation of TGF? maintains intervertebral disc homeostasis
    Authors: Q Bian, L Ma, A Jain, JL Crane, K Kebaish, M Wan, Z Zhang, X Edward Guo, PD Sponseller, CA Séguin, LH Riley, Y Wang, X Cao
    Bone Res, 2017;5(0):17008.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  113. Rad52 competes with Ku70/Ku86 for binding to S-region DSB ends to modulate antibody class-switch DNA recombination
    Authors: H Zan, C Tat, Z Qiu, JR Taylor, JA Guerrero, T Shen, P Casali
    Nat Commun, 2017;8(0):14244.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  114. Suppressive IL-17A(+)Foxp3(+) and ex-Th17 IL-17A(neg)Foxp3(+) Treg cells are a source of tumour-associated Treg cells
    Authors: S Downs-Cann, S Berkey, GM Delgoffe, RP Edwards, T Curiel, K Odunsi, DL Bartlett, N Obermajer
    Nat Commun, 2017;8(0):14649.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  115. Bone-induced expression of integrin ?3 enables targeted nanotherapy of breast cancer metastases
    Authors: MH Ross, AK Esser, GC Fox, AH Schmieder, X Yang, G Hu, D Pan, X Su, Y Xu, DV Novack, T Walsh, GA Colditz, GH Lukaszewic, E Cordell, JS Novack, JAJ Fitzpatric, DL Waning, KS Mohammad, TA Guise, GM Lanza, KN Weilbaeche
    Cancer Res., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  116. Suppression of Th17 cell differentiation by misshapen/NIK-related kinase MINK1
    Authors: G Fu, Q Xu, Y Qiu, X Jin, T Xu, S Dong, J Wang, Y Ke, H Hu, X Cao, D Wang, H Cantor, X Gao, L Lu
    J. Exp. Med., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  117. CYP4A in tumor-associated macrophages promotes pre-metastatic niche formation and metastasis
    Authors: XW Chen, TJ Yu, J Zhang, Y Li, HL Chen, GF Yang, W Yu, YZ Liu, XX Liu, CF Duan, HL Tang, M Qiu, CL Wang, H Zheng, J Yue, AM Guo, J Yang
    Oncogene, 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  118. Notch Balances Th17 and Induced Regulatory T Cell Functions in Dendritic Cells by Regulating Aldh1a2 Expression
    Authors: TS Zaman, H Arimochi, S Maruyama, C Ishifune, SI Tsukumo, A Kitamura, K Yasutomo
    J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  119. NLRP3 signaling drives macrophage-induced adaptive immune suppression in pancreatic carcinoma
    Authors: D Daley, VR Mani, N Mohan, N Akkad, GSDB Pandian, S Savadkar, KB Lee, A Torres-Her, B Aykut, B Diskin, W Wang, MS Farooq, AI Mahmud, G Werba, EJ Morales, S Lall, BJ Wadowski, AG Rubin, ME Berman, R Narayanan, M Hundeyin, G Miller
    J. Exp. Med., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  120. The frequency of Th17�cells in the small intestine exhibits a day-night variation dependent on circadian clock activity
    Authors: HP Thu Le, Y Nakamura, K Oh-Oka, K Ishimaru, S Nakajima, A Nakao
    Biochem. Biophys. Res. Commun., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  121. The Kielin/chordin-like Protein (KCP) Attenuates High Fat Diet Induced Obesity and Metabolic Syndrome in Mice
    Authors: A Soofi, KI Wolf, MP Emont, N Qi, G Martinez-S, E Grimley, W Ostwani, GR Dressler
    J. Biol. Chem., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  122. Wolf-Hirschhorn Syndrome Candidate 1 Is Necessary for Correct Hematopoietic and B Cell Development
    Authors: E Campos-San, N Deleyto-Se, V Dominguez, E Carrillo-d, K Ura, PP Rocha, J Kim, A Aljoufi, A Esteve-Cod, M Dabad, M Gut, H Heyn, Y Kaneda, K Nimura, JA Skok, ML Martinez-F, C Cobaleda
    Cell Rep, 2017;19(8):1586-1601.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  123. TLR7 Signaling Regulates Th17 Cells and Autoimmunity: Novel Potential for Autoimmune Therapy
    Authors: J Ye, Y Wang, X Liu, L Li, A Opejin, EC Hsueh, H Luo, T Wang, D Hawiger, G Peng
    J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  124. Local Inflammatory Cues Regulate Differentiation and Persistence of CD8(+) Tissue-Resident Memory T Cells
    Authors: T Bergsbaken, MJ Bevan, PJ Fink
    Cell Rep, 2017;19(1):114-124.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  125. Nuclear Proximity of Mtr4 to RNA Exosome Restricts DNA Mutational Asymmetry
    Authors: J Lim, PK Giri, D Kazadi, B Laffleur, W Zhang, V Grinstein, E Pefanis, LM Brown, E Ladewig, O Martin, Y Chen, R Rabadan, F Boyer, G Rothschild, M Cogné, E Pinaud, H Deng, U Basu
    Cell, 2017;169(3):523-537.e15.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  126. Bi-layered constructs of poly(glycerol-sebacate)-?-tricalcium phosphate for bone-soft tissue interface applications
    Authors: Atakan Tevlek
    Mater Sci Eng C Mater Biol Appl, 2017;72(0):316-324.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  127. mTORC2 controls Th9 polarization and allergic airway inflammation
    Authors: H Chen, L Zhang, P Wang, H Su, W Wang, Z Chu, L Zhang, X Zhang, Y Zhao
    Allergy, 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  128. Expression of antisense of microRNA-26a-5p in mesenchymal stem cells increases their therapeutic effects against cirrhosis
    Authors: L Chen, W Zeng, B Yang, X Cui, C Feng, L Wang, H Wang, X Zhou, P Li, F Lv, T Li
    Am J Transl Res, 2017;9(3):1500-1508.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  129. Inhibition of ubiquitin-specific protease 34 (USP34) induces epithelial-mesenchymal transition and promotes stemness in mammary epithelial cells
    Authors: E Oh, JY Kim, D Sung, Y Cho, N Lee, H An, YJ Kim, TM Cho, JH Seo
    Cell. Signal., 2017;36(0):230-239.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  130. Lamtor1 Is Critically Required for CD4(+) T Cell Proliferation and Regulatory T Cell Suppressive Function
    Authors: T Hosokawa, T Kimura, S Nada, T Okuno, D Ito, S Kang, S Nojima, K Yamashita, T Nakatani, Y Hayama, Y Kato, Y Kinehara, M Nishide, N Mikami, S Koyama, H Takamatsu, D Okuzaki, N Ohkura, S Sakaguchi, M Okada, A Kumanogoh
    J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  131. Interferon-gamma regulates inflammatory cell death by targeting necroptosis in experimental autoimmune arthritis
    Authors: SH Lee, JY Kwon, SY Kim, K Jung, ML Cho
    Sci Rep, 2017;7(1):10133.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  132. Attenuation of PKR-like ER Kinase (PERK) Signaling Selectively Controls Endoplasmic Reticulum Stress-induced Inflammation Without Compromising Immunological Responses
    Authors: LN Guthrie, K Abiraman, ES Plyler, NT Sprenkle, SA Gibson, BC McFarland, R Rajbhandar, AL Rowse, EN Benveniste, GP Meares
    J. Biol. Chem., 2016;291(30):15830-40.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  133. Restoration of Corneal Transparency by Mesenchymal Stem Cells.
    Authors: Sharad K Mittal, Masahiro Omoto, Afsaneh Amouzegar, Anuradha Sahu, Alexandra Rezazadeh, Kishore R Katikired, Dhvanit I Shah, Srikant K Sahu, Sunil K Chauhan
    Stem Cell Reports, 2016;0(0):2213-6711.
    Species: Mouse
    Sample Types: Transfected Whole Cells
    Applications: Bioassay
  134. Alternative splicing of MALT1 controls signalling and activation of CD4(+) T cells
    Authors: I Meininger, RA Griesbach, D Hu, T Gehring, T Seeholzer, A Bertossi, J Kranich, A Oeckinghau, AC Eitelhuber, U Greczmiel, A Gewies, M Schmidt-Su, J Ruland, T Brocker, V Heissmeyer, F Heyd, D Krappmann
    Nat Commun, 2016;7(0):11292.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  135. Beta 1-integrin ligation and TLR ligation enhance GM-CSF-induced ALDH1A2 expression in dendritic cells, but differentially regulate their anti-inflammatory properties
    Sci Rep, 2016;6(0):37914.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  136. SiRNA-mediated in vivo gene knockdown by acid-degradable cationic nanohydrogel particles
    Authors: Nadine Leber
    J Control Release, 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  137. All Trans Retinoic Acid, Transforming Growth Factor ? and Prostaglandin E2 in Mouse Plasma Synergize with Basophil-Secreted Interleukin-4 to M2 Polarize Murine Macrophages
    PLoS ONE, 2016;11(12):e0168072.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  138. Absence of miR-146a in podocytes increases risk of diabetic glomerulopathy via upregulation of erbb4 and notch-1
    Authors: Ha Won Lee
    J. Biol. Chem, 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  139. Pharmacologic modulation of ROR?t translates to efficacy in preclinical and translational models of psoriasis and inflammatory arthritis
    Sci Rep, 2016;6(0):37977.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  140. Young microglia restore amyloid plaque clearance of aged microglia
    Authors: Anna Daria
    EMBO J, 2016;0(0):.
    Species: Mouse
    Sample Types: Complex Sample Type
    Applications: Bioassay
  141. Treatment of refractory cutaneous ulcers with mixed sheets consisting of peripheral blood mononuclear cells and fibroblasts
    Authors: Koji Ueno
    Sci Rep, 2016;6(0):28538.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  142. Pharmacologic inhibition of Hsp90 to prevent GLT-1 degradation as an effective therapy for epilepsy
    Authors: Longze Sha
    J. Exp. Med, 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  143. Vimentin coordinates fibroblast proliferation and keratinocyte differentiation in wound healing via TGF-?-Slug signaling
    Proc Natl Acad Sci USA, 2016;113(30):E4320-7.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  144. Classical transient receptor potential 6 (TRPC6) channels support myofibroblast differentiation and development of experimental pulmonary fibrosis
    Authors: Katharina Hofmann
    Biochim. Biophys. Acta, 2016;1863(2):560-568.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  145. Differential effects of Pax3 on expression of polysialyltransferases STX and PST in TGF-?-treated normal murine mammary gland cells
    Exp Biol Med (Maywood), 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  146. Leptin directly promotes T-cell glycolytic metabolism to drive effector T-cell differentiation in a mouse model of autoimmunity
    Eur J Immunol, 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  147. Restoration of Corneal Transparency by Mesenchymal Stem Cells
    Stem Cell Reports, 2016;7(4):583-590.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  148. Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition
    Authors: Cédric Blanpain
    Cell Stem Cell, 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  149. Reduced TCR-dependent activation through citrullination of a T-cell epitope enhances Th17 development by disruption of the STAT3/5 balance
    Eur J Immunol, 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  150. CD8+ T Cells and Endogenous IL-10 Are Required for Resolution of Chemotherapy-Induced Neuropathic Pain
    Authors: Annemieke Kavelaars
    J. Neurosci., 2016;36(43):11074-11083.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  151. Affinity for self antigen selects Treg cells with distinct functional properties
    Nat Immunol, 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  152. The role of ?-smooth muscle actin in fibroblast-mediated matrix contraction and remodeling
    Authors: Nikolaos G Frangogian
    Biochim. Biophys. Acta, 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  153. GLUT-1-Dependent Glycolysis is Increased During Aging-related Lung Fibrosis and Phloretin Inhibits Lung Fibrosis
    Authors: Soo Jung Cho
    Am. J. Respir. Cell Mol. Biol, 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  154. T cells are necessary for ILC2 activation in house dust mite-induced allergic airway inflammation in mice
    Authors: BW Li, MJ de Bruijn, I Tindemans, M Lukkes, A KleinJan, HC Hoogsteden, RW Hendriks
    Eur J Immunol, 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  155. Autonomous membrane IgE signaling prevents IgE-memory formation
    Nat Immunol, 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  156. Th1 cells downregulate connexin 43 gap junctions in astrocytes via microglial activation
    Sci Rep, 2016;6(0):38387.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  157. IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iTreg cell balance.
    Authors: Basu R, Whitley S, Bhaumik S, Zindl C, Schoeb T, Benveniste E, Pear W, Hatton R, Weaver C
    Nat Immunol, 2015;16(3):286-95.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  158. ShcA regulates late stages of T cell development and peripheral CD4+ T cell numbers.
    Authors: Buckley M, Trampont P, Arandjelovic S, Fond A, Juncadella I, Ravichandran K
    J Immunol, 2015;194(4):1665-76.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  159. Testosterone suppresses hepatic inflammation by the downregulation of IL-17, CXCL-9, and CXCL-10 in a mouse model of experimental acute cholangitis.
    Authors: Schwinge D, Carambia A, Quaas A, Krech T, Wegscheid C, Tiegs G, Prinz I, Lohse A, Herkel J, Schramm C
    J Immunol, 2015;194(6):2522-30.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  160. Long non-coding RNAs (LncRNA) regulated by transforming growth factor (TGF) beta: LncRNA-hit-mediated TGFbeta-induced epithelial to mesenchymal transition in mammary epithelia.
    Authors: Richards E, Zhang G, Li Z, Permuth-Wey J, Challa S, Li Y, Kong W, Dan S, Bui M, Coppola D, Mao W, Sellers T, Cheng J
    J Biol Chem, 2015;290(11):6857-67.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  161. Regulatory T cell reprogramming toward a Th2-cell-like lineage impairs oral tolerance and promotes food allergy.
    Authors: Noval Rivas M, Burton O, Wise P, Charbonnier L, Georgiev P, Oettgen H, Rachid R, Chatila T
    Immunity, 2015;42(3):512-23.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  162. Itk signals promote neuroinflammation by regulating CD4+ T-cell activation and trafficking.
    Authors: Kannan A, Kim D, August A, Bynoe M
    J Neurosci, 2015;35(1):221-33.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  163. Blocking follistatin-like 1 attenuates bleomycin-induced pulmonary fibrosis in mice.
    Authors: Dong Y, Geng Y, Li L, Li X, Yan X, Fang Y, Li X, Dong S, Liu X, Li X, Yang X, Zheng X, Xie T, Liang J, Dai H, Liu X, Yin Z, Noble P, Jiang D, Ning W
    J Exp Med, 2015;212(2):235-52.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  164. Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros-derived hematopoietic stem cells.
    Authors: Hadland B, Varnum-Finney B, Poulos M, Moon R, Butler J, Rafii S, Bernstein I
    J Clin Invest, 2015;125(5):2032-45.
    Species: Mouse
    Sample Types: Protein
    Applications: Bioassay
  165. Beclin 1 regulates neuronal transforming growth factor-beta signaling by mediating recycling of the type I receptor ALK5.
    Authors: O'Brien C, Bonanno L, Zhang H, Wyss-Coray T
    Mol Neurodegener, 2015;10(1):69.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  166. Mesenchymal stem/stromal cells protect against autoimmunity via CCL2-dependent recruitment of myeloid-derived suppressor cells.
    Authors: Lee H, Ko J, Jeong H, Ko A, Kim M, Wee W, Yoon S, Oh J
    J Immunol, 2015;194(8):3634-45.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  167. Retinoic acid can exacerbate T cell intrinsic TLR2 activation to promote tolerance.
    Authors: Nguyen, Vivien, Pearson, Kandyce, Kim, Jee-Hyun, Kamdar, Karishma, DePaolo, R Willia
    PLoS ONE, 2015;10(3):e0118875.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  168. Monocyte Chemoattractant Protein-Induced Protein 1 (MCPIP1) Enhances Angiogenic and Cardiomyogenic Potential of Murine Bone Marrow-Derived Mesenchymal Stem Cells.
    Authors: Labedz-Maslowska A, Lipert B, Berdecka D, Kedracka-Krok S, Jankowska U, Kamycka E, Sekula M, Madeja Z, Dawn B, Jura J, Zuba-Surma E
    PLoS ONE, 2015;10(7):e0133746.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  169. miR-148a is upregulated by Twist1 and T-bet and promotes Th1-cell survival by regulating the proapoptotic gene Bim.
    Authors: Haftmann C, Stittrich A, Zimmermann J, Fang Z, Hradilkova K, Bardua M, Westendorf K, Heinz G, Riedel R, Siede J, Lehmann K, Weinberger E, Zimmel D, Lauer U, Haupl T, Sieper J, Backhaus M, Neumann C, Hoffmann U, Porstner M, Chen W, Grun J, Baumgrass R, Matz M, Lohning M, Scheffold A, Wittmann J, Chang H, Rajewsky N, Jack H, Radbruch A, Mashreghi M
    Eur J Immunol, 2015;45(4):1192-205.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  170. Myocardin-related transcription factors control the motility of epicardium-derived cells and the maturation of coronary vessels.
    Authors: Trembley M, Velasquez L, de Mesy Bentley K, Small E
    Development, 2015;142(1):21-30.
  171. A functional polymorphism of Ptpn22 is associated with type 1 diabetes in the BioBreeding rat.
    Authors: Sarmiento J, Wallis R, Ning T, Marandi L, Chao G, Veillette A, Lernmark A, Paterson A, Poussier P
    J Immunol, 2015;194(2):615-29.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  172. Dendritic cell SIRT1-HIF1alpha axis programs the differentiation of CD4+ T cells through IL-12 and TGF-beta1.
    Authors: Liu G, Bi Y, Xue L, Zhang Y, Yang H, Chen X, Lu Y, Zhang Z, Liu H, Wang X, Wang R, Chu Y, Yang R
    Proc Natl Acad Sci U S A, 2015;112(9):E957-65.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  173. Novel mechanism of macrophage-mediated metastasis revealed in a zebrafish model of tumor development.
    Authors: Wang J, Cao Z, Zhang X, Nakamura M, Sun M, Hartman J, Harris R, Sun Y, Cao Y
    Cancer Res, 2015;75(2):306-15.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  174. Impaired dendritic cell function in a spontaneous autoimmune polyneuropathy.
    Authors: Quan S, Kim H, Dukala D, Sheng J, Soliven B
    J Immunol, 2015;194(9):4175-84.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  175. IL-21 induces IL-22 production in CD4+ T cells.
    Authors: Yeste A, Mascanfroni I, Nadeau M, Burns E, Tukpah A, Santiago A, Wu C, Patel B, Kumar D, Quintana F
    Nat Commun, 2014;5(0):3753.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  176. Siah2 regulates tight junction integrity and cell polarity through control of ASPP2 stability.
    Authors: Kim H, Claps G, Moller A, Bowtell D, Lu X, Ronai Z
    Oncogene, 2014;33(15):2004-10.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  177. The transcription factor IRF8 activates integrin-mediated TGF-beta signaling and promotes neuroinflammation.
    Authors: Yoshida Y, Yoshimi R, Yoshii H, Kim D, Dey A, Xiong H, Munasinghe J, Yazawa I, O'Donovan M, Maximova O, Sharma S, Zhu J, Wang H, Morse H, Ozato K
    Immunity, 2014;40(2):187-98.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  178. A Snail1/Notch1 signalling axis controls embryonic vascular development.
    Authors: Wu Z, Rowe R, Lim K, Lin Y, Willis A, Tang Y, Li X, Nor J, Maillard I, Weiss S
    Nat Commun, 2014;5(0):3998.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  179. Cell-extrinsic CTLA4-mediated regulation of dendritic cell maturation depends on STAT3.
    Authors: Kowalczyk A, D'Souza C, Zhang L
    Eur J Immunol, 2014;44(4):1143-55.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  180. Hepatocytes induce Foxp3(+) regulatory T cells by Notch signaling.
    Authors: Burghardt S, Claass B, Erhardt A, Karimi K, Tiegs G
    J Leukoc Biol, 2014;96(4):571-7.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  181. Retinoic acid prevents mesenteric lymph node dendritic cells from inducing IL-13-producing inflammatory Th2 cells.
    Authors: Yokota-Nakatsuma A, Takeuchi H, Ohoka Y, Kato C, Song S, Hoshino T, Yagita H, Ohteki T, Iwata M
    Mucosal Immunol, 2014;7(4):786-801.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  182. Tracking the elusive fibrocyte: identification and characterization of collagen-producing hematopoietic lineage cells during murine wound healing.
    Authors: Suga H, Rennert R, Rodrigues M, Sorkin M, Glotzbach J, Januszyk M, Fujiwara T, Longaker M, Gurtner G
    Stem Cells, 2014;32(5):1347-60.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  183. Laminin alpha1 regulates age-related mesangial cell proliferation and mesangial matrix accumulation through the TGF-beta pathway.
    Authors: Ning L, Kurihara H, de Vega S, Ichikawa-Tomikawa N, Xu Z, Nonaka R, Kazuno S, Yamada Y, Miner J, Arikawa-Hirasawa E
    Am J Pathol, 2014;184(6):1683-94.
    Species: Mouse
    Sample Types: N/A
    Applications: ELISA Developmet
  184. Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment.
    Authors: Seth A, Ye J, Yu N, Guez F, Bedford D, Neale G, Cordi S, Brindle P, Lemaigre F, Kaestner K, Sosa-Pineda B
    Development, 2014;141(3):538-47.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  185. Brain glycolipids suppress T helper cells and inhibit autoimmune demyelination.
    Authors: Mycko M, Sliwinska B, Cichalewska M, Cwiklinska H, Raine C, Selmaj K
    J Neurosci, 2014;34(25):8646-58.
  186. Lnk/Sh2b3 controls the production and function of dendritic cells and regulates the induction of IFN-gamma-producing T cells.
    Authors: Mori T, Iwasaki Y, Seki Y, Iseki M, Katayama H, Yamamoto K, Takatsu K, Takaki S
    J Immunol, 2014;193(4):1728-36.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  187. Blockade of IL-33 release and suppression of type 2 innate lymphoid cell responses by helminth secreted products in airway allergy.
    Authors: McSorley H, Blair N, Smith K, McKenzie A, Maizels R
    Mucosal Immunol, 2014;7(5):1068-78.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  188. The hippo pathway effector Yap controls patterning and differentiation of airway epithelial progenitors.
    Authors: Mahoney J, Mori M, Szymaniak A, Varelas X, Cardoso W
    Dev Cell, 2014;30(2):137-50.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  189. Toll-like receptor 9 mediated responses in cardiac fibroblasts.
    Authors: Ohm I, Alfsnes K, Belland Olsen M, Ranheim T, Sandanger O, Dahl T, Aukrust P, Finsen A, Yndestad A, Vinge L
    PLoS ONE, 2014;9(8):e104398.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  190. Integrin-mediated type II TGF-beta receptor tyrosine dephosphorylation controls SMAD-dependent profibrotic signaling.
    Authors: Chen X, Wang H, Liao H, Hu W, Gewin L, Mernaugh G, Zhang S, Zhang Z, Vega-Montoto L, Vanacore R, Fassler R, Zent R, Pozzi A
    J Clin Invest, 2014;124(8):3295-310.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  191. Unexpected phenotype of mice lacking Shcbp1, a protein induced during T cell proliferation.
    Authors: Buckley M, Arandjelovic S, Trampont P, Kim T, Braciale T, Ravichandran K
    PLoS ONE, 2014;9(8):e105576.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  192. Attenuation of experimental colitis in glutathione peroxidase 1 and catalase double knockout mice through enhancing regulatory T cell function.
    Authors: Kim H, Lee A, Choi E, Kie J, Lim W, Lee H, Moon B, Seoh J
    PLoS ONE, 2014;9(4):e95332.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  193. Myostatin stimulates, not inihibits, C2C12 myoblast proliferation.
    Authors: Rodgers B, Wiedeback B, Hoversten K, Jackson M, Walker R, Thompson T
    Endocrinology, 2014;155(3):670-5.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  194. Molecular and cellular features of murine craniofacial and trunk neural crest cells as stem cell-like cells.
    Authors: Hagiwara, Kunie, Obayashi, Takeshi, Sakayori, Nobuyuki, Yamanishi, Emiko, Hayashi, Ryuhei, Osumi, Noriko, Nakazawa, Toru, Nishida, Kohji
    PLoS ONE, 2014;9(1):e84072.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  195. The alarmin IL-33 promotes regulatory T-cell function in the intestine.
    Authors: Schiering C, Krausgruber T, Chomka A, Frohlich A, Adelmann K, Wohlfert E, Pott J, Griseri T, Bollrath J, Hegazy A, Harrison O, Owens B, Lohning M, Belkaid Y, Fallon P, Powrie F
    Nature, 2014;513(7519):564-8.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  196. Matrix metalloproteinase-9 deficiency attenuates diabetic nephropathy by modulation of podocyte functions and dedifferentiation.
    Authors: Li S, Huang P, Yang A, Tarng D, Yang W, Lin C, Chen J, Schmid-Schonbein G, Lin S
    Kidney Int, 2014;86(2):358-69.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  197. Real-time imaging of the epithelial-mesenchymal transition using microRNA-200a sequence-based molecular beacon-conjugated magnetic nanoparticles.
    Authors: Choi Y, Kim H, Woo J, Hwang E, Cho K, Kim S, Moon W
    PLoS ONE, 2014;9(7):e102164.
    Species: Canine
    Sample Types: Whole Cells
    Applications: Bioassay
  198. Alternative splice variants of AID are not stoichiometrically present at the protein level in chronic lymphocytic leukemia.
    Authors: Rebhandl S, Huemer M, Zaborsky N, Gassner F, Catakovic K, Felder T, Greil R, Geisberger R
    Eur J Immunol, 2014;44(7):2175-87.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  199. TGF-beta and opioid receptor signaling crosstalk results in improvement of endogenous and exogenous opioid analgesia under pathological pain conditions.
    Authors: Lantero A, Tramullas M, Pilar-Cuellar F, Valdizan E, Santillan R, Roques B, Hurle M
    J Neurosci, 2014;34(15):5385-95.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  200. Elongated TCR alpha chain CDR3 favors an altered CD4 cytokine profile.
    Authors: Reynolds C, Chong D, Raynsford E, Quigley K, Kelly D, Llewellyn-Hughes J, Altmann D, Boyton R
    BMC Biol, 2014;12(0):32.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  201. HIV Nef expression favors the relative preservation of CD4+ T regulatory cells that retain some important suppressive functions.
    Authors: Chrobak P, Afkhami S, Priceputu E, Poudrier J, Meunier C, Hanna Z, Sparwasser T, Jolicoeur P
    J Immunol, 2014;192(4):1681-92.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  202. IL-4/IL-13-dependent and independent expression of miR-124 and its contribution to M2 phenotype of monocytic cells in normal conditions and during allergic inflammation.
    Authors: Veremeyko, Tatyana, Siddiqui, Shafiudd, Sotnikov, Ilya, Yung, Amanda, Ponomarev, Eugene D
    PLoS ONE, 2013;8(12):e81774.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  203. Distinctive subdomains in the resorbing surface of osteoclasts.
    Authors: Szewczyk K, Fuller K, Chambers T
    PLoS ONE, 2013;8(3):e60285.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  204. Integration of multiple signaling regulates through apoptosis the differential osteogenic potential of neural crest-derived and mesoderm-derived Osteoblasts.
    Authors: Li S, Meyer N, Quarto N, Longaker M
    PLoS ONE, 2013;8(3):e58610.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  205. Activation of PPAR-alpha induces cell cycle arrest and inhibits transforming growth factor-beta1 induction of smooth muscle cell phenotype in 10T1/2 mesenchymal cells.
    Authors: Lien S, Wei S, Chang S, Chang M, Chang J, Chiu J
    Cell Signal, 2013;25(5):1252-63.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  206. FAK-related nonkinase is a multifunctional negative regulator of pulmonary fibrosis.
    Authors: Ding Q, Cai G, Hu M, Yang Y, Zheng A, Tang Q, Gladson C, Hayasaka H, Wu H, You Z, Southern B, Grove L, Rahaman S, Fang H, Olman M
    Am J Pathol, 2013;182(5):1572-84.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  207. Thrombospondin-1 induction in the diabetic myocardium stabilizes the cardiac matrix in addition to promoting vascular rarefaction through angiopoietin-2 upregulation.
    Authors: Gonzalez-Quesada C, Cavalera M, Biernacka A, Kong P, Lee D, Saxena A, Frunza O, Dobaczewski M, Shinde A, Frangogiannis N
    Circ Res, 2013;113(12):1331-44.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  208. Control of T helper 2 responses by transcription factor IRF4-dependent dendritic cells.
    Authors: Gao Y, Nish S, Jiang R, Hou L, Licona-Limon P, Weinstein J, Zhao H, Medzhitov R
    Immunity, 2013;39(4):722-32.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  209. Endothelial dysfunction exacerbates renal interstitial fibrosis through enhancing fibroblast Smad3 linker phosphorylation in the mouse obstructed kidney.
    Authors: Sun Y, Qu X, Li X, Nikolic-Paterson D, Li J
    PLoS ONE, 2013;8(12):e84063.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Cell Culture
  210. Interferon gamma suppresses collagen-induced arthritis by regulation of Th17 through the induction of indoleamine-2,3-deoxygenase.
    Authors: Lee J, Lee J, Park M, Lim M, Park E, Kim E, Yang E, Lee S, Jhun J, Park S, Kim H, Cho M
    PLoS ONE, 2013;8(4):e60900.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  211. TNF-alpha promotes cerebral pericyte remodeling in vitro, via a switch from alpha1 to alpha2 integrins.
    Authors: Tigges U, Boroujerdi A, Welser-Alves J, Milner R
    J Neuroinflammation, 2013;10(0):33.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  212. The loss of Trps1 suppresses ureteric bud branching because of the activation of TGF-beta signaling.
    Authors: Gui T, Sun Y, Gai Z, Shimokado A, Muragaki Y, Zhou G
    Dev Biol, 2013;377(2):415-27.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  213. Exposure to atmospheric particulate matter enhances Th17 polarization through the aryl hydrocarbon receptor.
    Authors: van Voorhis, Michael, Knopp, Samantha, Julliard, Walker, Fechner, John H, Zhang, Xiaoji, Schauer, James J, Mezrich, Joshua D
    PLoS ONE, 2013;8(12):e82545.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  214. Regulation of innate CD8+ T-cell activation mediated by cytokines.
    Proc Natl Acad Sci U S A, 2012;109(25):9971-6.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay

FAQs

  1. Can I reconstitute Recombinant Mouse TGF beta 1 Protein (Catalog # 7666-MB or 7666-MB/CF) in PBS or water?

    • Recombinant Mouse TGF beta 1 Protein (Catalog # 7666-MB or 7666-MB/CF) needs to be reconstituted to 50 μg/mL in sterile 4 mM HCl containing 0.1% BSA, or 4 mM HCl. This protein is hydrophobic by nature, so it requires an acidic buffer for reconstitution to go completely into solution. Stability testing has been evaluated on the protein with these reconstitution conditions; we can guarantee performance under these reconstitution conditions. When the protein is diluted with the cell culture media or buffers to the working concentration, the concentration of the acid should be buffered or negligible.

       

      Recombinant Mouse TGF beta 1 Protein needs to be reconstituted to 50 μg/mL in sterile 4 mM HCl containing 0.1% BSA, or 4 mM HCl.  This protein is hydrophobic by nature, so it requires an acidic buffer for reconstitution to go completely into solution. Stability testing has been evaluated on the protein with these reconstitution conditions; we can guarantee performance under these reconstitution conditions. When the protein is diluted with the cell culture media or buffers to the working concentration, the concentration of the acid should be buffered or negligible.

  2. Is Recombinant Mouse TGF-beta 1 Protein (Catalog # 7666-MB) the latent or mature form?

    • Recombinant Mouse TGF-beta 1 Protein (Catalog # 7666-MB) is composed of Ala279-Ser390, accession # P04202, which corresponds to mature mouse TGFb1.

View all Proteins and Enzyme FAQs

Reviews for Recombinant Mouse TGF-beta 1 Protein

Average Rating: 5 (Based on 12 Reviews)

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Recombinant Mouse TGF-beta 1 Protein
By Anonymous on 12/22/2020
Application: In vitro bioactivity in cell culture

Recombinant Mouse TGF-beta 1 Protein
By Anonymous on 12/02/2020
Application: In vitro bioactivity in cell culture

Recombinant Mouse TGF-beta 1 Protein
By Anonymous on 03/13/2020
Application: In vitro bioactivity in cell culture

Recombinant Mouse TGF-beta 1 Protein
By Anonymous on 02/15/2020
Application: Media additive for protein or antibody production

Recombinant Mouse TGF-beta 1 Protein
By Anonymous on 03/28/2019
Application: Binding assay/Protein-protein interaction
Reason for Rating: I used this protein in a competition ELISA to see if the antibodies had similar epitopes.

I coated my plate with 50ng/well of recombinant mouse TGF beta 1 protein (cat# 7666-MB) overnight. I washed and blocked with reagent diluent 2 DY995 for 2hr, washed and added another company's TGFb1 antibody at different concentrations 0.2-100ug/mL in reagent diluent 2 and incubated 1hr. I did not wash my wells but add the two antibodies MAB240-biotinylated it in-house and BAF at a final concentration of 2ug/mL and incubated 1hr diluted in reagent diluent 2. I washed and added streptavidin-HRP DY998 (1:200) and incubated 30 mins, washed and developed with the substrate pack DY999. I found MAB240 competed for binding to the mouse TGF beta 1 protein when the competitor's antibody was present but the chicken polyclonal was not inhibited.


Recombinant Mouse TGF-beta 1 Protein
By Anonymous on 01/28/2019
Application: In vitro bioactivity in cell culture

Recombinant Mouse TGF-beta 1 Protein
By Anonymous on 06/15/2018
Application: Binding assay/Protein-protein interaction

Recombinant Mouse TGF-beta 1 Protein
By Anonymous on 05/03/2018
Application: In vitro bioactivity in cell culture

Recombinant Mouse TGF-beta 1 Protein
By Anonymous on 04/26/2018
Application: Apoptosis assay

Recombinant Mouse TGF-beta 1 Protein
By Anonymous on 04/22/2018
Application: Apoptosis assay

Recombinant Mouse TGF-beta 1 Protein
By Anonymous on 05/10/2017
Application: CellProlif

Recombinant Mouse TGF-beta 1 Protein
By Anonymous on 02/01/2017
Application: In vivo study