Recombinant Mouse TGF-beta 1 Protein Summary
Ala279-Ser390
Analysis
Product Datasheets
Carrier Free
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
7666-MB
Formulation | Lyophilized from a 0.2 μm filtered solution in HCl with BSA as a carrier protein. |
Reconstitution | Reconstitute at 50 μg/mL in 4 mM HCl containing at least 0.1% human or bovine serum albumin. |
Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
7666-MB/CF
Formulation | Lyophilized from a 0.2 μm filtered solution in HCl. |
Reconstitution | Reconstitute at 50 μg/mL in 4 mM HCl. |
Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
Data Image

Recombinant mouse TGF-beta 1 (7666-MB) inhibits IL-4-dependent proliferation in the HT-2 mouse T cell line. The ED50 for this effect is 0.04-0.2 ng/mL.
Reconstitution Calculator
Background: TGF-beta 1
TGF-beta 1 (transforming growth factor beta 1) is one of three closely related mammalian members of the large TGF‑ beta superfamily that share a characteristic cystine knot structure (1‑7). TGF‑ beta 1, -2 and -3 are highly pleiotropic cytokines that are proposed to act as cellular switches that regulate processes such as immune function, proliferation and epithelial‑mesenchymal transition (1‑4). Each TGF‑ beta isoform has some non‑redundant functions; for TGF‑ beta 1, mice with targeted deletion show defects in hematopoiesis and endothelial differentiation, and die of overwhelming inflammation (2). Human or mouse TGF‑ beta 1 cDNA encodes a 390 amino acid (aa) precursor that contains a 29 aa signal peptide and a 361 aa proprotein (8). A furin‑like convertase processes the proprotein to generate an N‑terminal 249 aa latency‑associated peptide (LAP) and a C‑terminal 112 aa mature TGF‑ beta 1 (8, 9). Disulfide‑linked homodimers of LAP and TGF‑ beta 1 remain non‑covalently associated after secretion, forming the small latent TGF‑ beta 1 complex (8‑10). Covalent linkage of LAP to one of three latent TGF‑ beta binding proteins (LTBPs) creates a large latent complex that may interact with the extracellular matrix (9, 10). TGF‑ beta is activated from latency by pathways that include actions of the protease plasmin, matrix metalloproteases, thrombospondin 1 and a subset of integrins (10). Mature mouse TGF‑ beta 1 shares 99‑100% aa sequence identity with human, rat, equine, porcine, canine and bovine TGF‑ beta 1. It demonstrates cross‑species activity (1). TGF‑ beta 1 signaling begins with high‑affinity binding to a type II ser/thr kinase receptor termed TGF‑ beta RII. This receptor then phosphorylates and activates a second ser/thr kinase receptor, TGF‑ beta RI (also called activin receptor‑like kinase (ALK) ‑5), or alternatively, ALK‑1. This complex phosphorylates and activates Smad proteins that regulate transcription (3, 11, 12). Contributions of the accessory receptors betaglycan (also known as TGF‑ beta RIII) and endoglin, or use of Smad‑independent signaling pathways, allow for disparate actions observed in response to TGF‑ beta in different contexts (11).
- Derynck, R. and K. Miyazono (2008) Cold Spring Harbor Laboratory Press, 29.
- Dunker, N. and K. Krieglstein (2000) Eur. J. Biochem. 267:6982.
- Wahl, S.M. (2006) Immunol. Rev. 213:213.
- Chang, H. et al. (2002) Endocr. Rev. 23:787.
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- Miyazono, K. et al. (1988) J. Biol. Chem. 263:6407.
- Oklu, R. and R. Hesketh (2000) Biochem. J. 352:601.
- de Caestecker, M. et al. (2004) Cytokine Growth Factor Rev. 15:1.
- Zuniga, J.E. et al. (2005) J. Mol. Biol. 354:1052.
Citations for Recombinant Mouse TGF-beta 1 Protein
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
194
Citations: Showing 1 - 10
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Oral therapy with colonization factor antigen I prevents development of type 1 diabetes in Non-obese Diabetic mice
Authors: AS Nelson, M Maddaloni, JR Abbott, C Hoffman, A Akgul, C Ohland, RZ Gharaibeh, C Jobin, TM Brusko, DW Pascual
Sci Rep, 2020;10(1):6156.
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: ELISA Standard -
Novel AXL-specific inhibitor ameliorates kidney dysfunction through the inhibition of epithelial-to-mesenchymal transition of renal tubular cells
Authors: A Kurata, Y Tachibana, T Takahashi, N Horiba
PLoS ONE, 2020;15(4):e0232055.
Species: Rat
Sample Types: Whole Cells
Applications: Cell Culture -
Osteoprotegerin is More than a Possible Serum Marker in Liver Fibrosis: A Study into its Function in Human and Murine Liver
Authors: A Adhyatmika, L Beljaars, KSS Putri, H Habibie, CE Boorsma, C Reker-Smit, T Luangmonko, B Guney, A Haak, KA Mangnus, E Post, K Poelstra, K Ravnskjaer, P Olinga, BN Melgert
Pharmaceutics, 2020;12(5):.
Species: Mouse
Sample Types: Whole Tissue
Applications: Tissue Culture -
NFAT-Specific Inhibition by dNP2-VIVITAmeliorates Autoimmune Encephalomyelitisby Regulation of Th1 and Th17
Authors: HG Lee, LK Kim, JM Choi
Mol Ther Methods Clin Dev, 2020;16(0):32-41.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Activation of aryl hydrocarbon receptor signaling by a novel agonist ameliorates autoimmune encephalomyelitis
Authors: A Abdullah, M Maged, I Hairul-Isl, A Osama I, H Maha, A Manal, H Hamza
PLoS ONE, 2019;14(4):e0215981.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Blocking interleukin-6 trans-signaling protects against renal fibrosis by suppressing STAT3 activation
Authors: W Chen, H Yuan, W Cao, T Wang, W Chen, H Yu, Y Fu, B Jiang, H Zhou, H Guo, X Zhao
Theranostics, 2019;9(14):3980-3991.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay -
Identification of a pro-angiogenic functional role for FSP1-positive fibroblast subtype in wound healing
Authors: S Saraswati, SMW Marrow, LA Watch, PP Young
Nat Commun, 2019;10(1):3027.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Ablation of RhoA impairs Th17 cell differentiation and alleviates house dust mite-triggered allergic airway inflammation
Authors: JQ Yang, KW Kalim, Y Li, Y Zheng, F Guo
J. Leukoc. Biol., 2019;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Label-free quantitative proteomics identifies transforming growth factorβ1 (TGF-?1) as an inhibitor of adipogenic transformation in OP9-DL1 cells and primary thymic stromal cells
Authors: J Tan, Y Wang, S Wang, S Wu, Z Yuan, X Zhu
Cell Biosci, 2019;9(0):48.
Species: Mouse
Sample Types: Whole Cells
Applications: ChIP -
5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine derivatives as inhibitors of full-length RORγt
Authors: C Lao, X Zhou, H Chen, F Wei, Z Huang, C Bai
Bioorg. Chem., 2019;90(0):103077.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Salvia miltiorrhiza and Carthamus tinctorius Extract Prevents Cardiac Fibrosis and Dysfunction after Myocardial Infarction by Epigenetically Inhibiting Smad3 Expression
Authors: J Yang, B Wang, N Li, Q Zhou, W Zhou, Z Zhan
Evid Based Complement Alternat Med, 2019;2019(0):6479136.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Gas6 Prevents Epithelial-Mesenchymal Transition in Alveolar Epithelial Cells via Production of PGE2, PGD2 and Their Receptors
Authors: J Jung, YJ Lee, YH Choi, EM Park, HS Kim, JL Kang
Cells, 2019;8(7):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
miRNA profiling of urinary exosomes to assess the progression of acute kidney injury
Authors: H Sonoda, BR Lee, KH Park, D Nihalani, JH Yoon, M Ikeda, SH Kwon
Sci Rep, 2019;9(1):4692.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Enhanced glycolytic metabolism supports transmigration of brain-infiltrating macrophages in multiple sclerosis
Authors: DK Kaushik, A Bhattachar, R Mirzaei, KS Rawji, Y Ahn, JM Rho, VW Yong
J. Clin. Invest., 2019;130(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Foxp1 is critical for the maintenance of regulatory T-cell homeostasis and suppressive function
Authors: J Ren, L Han, J Tang, Y Liu, X Deng, Q Liu, P Hao, X Feng, B Li, H Hu, H Wang
PLoS Biol., 2019;17(5):e3000270.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Pirfenidone prevents and reverses hepatic insulin resistance and steatohepatitis by polarizing M2 macrophages
Authors: G Chen, Y Ni, N Nagata, L Xu, F Zhuge, M Nagashimad, S Kaneko, T Ota
Lab. Invest., 2019;0(0):.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay -
Pharmacological inhibition of ?-catenin/BCL9 interaction overcomes resistance to immune checkpoint blockades by modulating Treg cells
Authors: M Feng, JQ Jin, L Xia, T Xiao, S Mei, X Wang, X Huang, J Chen, M Liu, C Chen, S Rafi, AX Zhu, YX Feng, D Zhu
Sci Adv, 2019;5(5):eaau5240.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Cutting Edge: ATM Influences Germinal Center Integrity
Authors: L Nicolas, M Cols, R Smolkin, KC Fernandez, WT Yewdell, WF Yen, S Zha, BQ Vuong, J Chaudhuri
J. Immunol., 2019;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Inhibition of Rho-Kinase Downregulates Th17 Cells and Ameliorates Hepatic Fibrosis by Schistosoma japonicum Infection
Authors: W Zhou, Y Yang, C Mei, P Dong, S Mu, H Wu, Y Zhou, Y Zheng, F Guo, JQ Yang
Cells, 2019;8(10):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Estrogen receptor ? in T cells suppresses follicular helper T cell responses and prevents autoimmunity
Authors: DH Kim, HJ Park, HS Park, JU Lee, C Ko, MC Gye, JM Choi
Exp. Mol. Med., 2019;51(4):41.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Targeting of dermal myofibroblasts through death receptor 5 arrests fibrosis in mouse models of scleroderma
Authors: JS Park, Y Oh, YJ Park, O Park, H Yang, S Slania, LK Hummers, AA Shah, HT An, J Jang, MR Horton, J Shin, HC Dietz, E Song, DH Na, EJ Park, K Kim, KC Lee, VV Roschke, J Hanes, MG Pomper, S Lee
Nat Commun, 2019;10(1):1128.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Inhibins regulate peripheral regulatory T cell induction through modulation of dendritic cell function
Authors: M de la Fuen, R Olguín-Alo, S Ortega-Fra, LC Bonifaz, G Soldevila
FEBS Open Bio, 2019;9(1):137-147.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Resolution of Cutaneous Leishmaniasis and Persistence of Leishmania major in the Absence of Arginase 1
Authors: K Paduch, A Debus, B Rai, U Schleicher, C Bogdan
J. Immunol., 2019;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The Tec kinase ITK is essential for ILC2 survival and epithelial integrity in the intestine
Authors: HS Cho, A Reboldi, JA Hall, LJ Berg
Nat Commun, 2019;10(1):784.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
MYMD-1, a Novel Immunometabolic Regulator, Ameliorates Autoimmune Thyroiditis via Suppression of Th1 Responses and TNF-? Release
Authors: G Di Dalmazi, P Chalan, P Caturegli
J. Immunol., 2019;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Pathogenic function of bystander-activated memory-like CD4+ T cells in autoimmune encephalomyelitis
Authors: HG Lee, JU Lee, DH Kim, S Lim, I Kang, JM Choi
Nat Commun, 2019;10(1):709.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
DGAT1 inhibits retinol-dependent regulatory T cell formation and mediates autoimmune encephalomyelitis
Authors: KL Graham, BJ Werner, KM Moyer, AK Patton, CR Krois, HS Yoo, M Tverskoy, M LaJevic, JL Napoli, RA Sobel, BA Zabel, EC Butcher
Proc. Natl. Acad. Sci. U.S.A., 2019;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Microglia are an essential component of the neuroprotective scar that forms after spinal cord injury
Authors: V Bellver-La, F Bretheau, B Mailhot, N Vallières, M Lessard, ME Janelle, N Vernoux, MÈ Tremblay, T Fuehrmann, MS Shoichet, S Lacroix
Nat Commun, 2019;10(1):518.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Salvia miltiorrhiza and Carthamus tinctorius Extract Prevents Cardiac Fibrosis and Dysfunction after Myocardial Infarction by Epigenetically Inhibiting Smad3 Expression
Authors: J Yang, B Wang, N Li, Q Zhou, W Zhou, Z Zhan
Evid Based Complement Alternat Med, 2019;2019(0):6479136.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Putative endothelial progenitor cells do not promote vascular repair but attenuate pericyte-myofibroblast transition in UUO-induced renal fibrosis
Authors: J Yang, M Wang, F Zhu, J Sun, H Xu, OL Chong Lee, Z Zhao, G Pei, H Zhu, C Cao, X He, Y Huang, Z Ma, L Liu, L Wang, Y Ning, W Liu, G Xu, X Wang, R Zeng, Y Yao
Stem Cell Res Ther, 2019;10(1):104.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Fibulin-1c regulates transforming growth factor-beta activation in pulmonary tissue fibrosis
Authors: G Liu, MA Cooley, AG Jarnicki, T Borghuis, PM Nair, G Tjin, AC Hsu, TJ Haw, M Fricker, CL Harrison, B Jones, NG Hansbro, PA Wark, JC Horvat, WS Argraves, BG Oliver, DA Knight, JK Burgess, PM Hansbro
JCI Insight, 2019;5(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Does co-transplantation of mesenchymal and spermatogonial stem cells improve reproductive efficiency and safety in mice?
Authors: P Kadam, E Ntemou, J Onofre, D Van Saen, E Goossens
Stem Cell Res Ther, 2019;10(1):310.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Tangeretin attenuates lipopolysaccharide-induced acute lung injury through Notch signaling pathway via suppressing Th17?cell response in mice
Authors: M Li, Y Zhao, D Qi, J He, D Wang
Microb. Pathog., 2019;138(0):103826.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Impact of aging on transition of acute kidney injury to chronic kidney disease
Authors: MG Kim, J Yang, YS Ko, HY Lee, SW Oh, WY Cho, SK Jo
Sci Rep, 2019;9(1):18445.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
TGFbeta-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis
Authors: J Li, A Ayoub, Y Xiu, X Yin, JO Sanders, A Mesfin, L Xing, Z Yao, BF Boyce
Nat Commun, 2019;10(1):2795.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation
Authors: AA Lombardi, AA Gibb, E Arif, DW Kolmetzky, D Tomar, TS Luongo, P Jadiya, EK Murray, PK Lorkiewicz, G Hajnóczky, E Murphy, ZP Arany, DP Kelly, KB Margulies, BG Hill, JW Elrod
Nat Commun, 2019;10(1):4509.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Oral flavonoid fisetin treatment protects against prolonged high-fat-diet-induced cardiac dysfunction by regulation of multicombined signaling
Authors: LF Hu, J Feng, X Dai, Y Sun, M Xiong, L Lai, S Zhong, C Yi, G Chen, H Li, Q Yang, Q Kuang, T Long, J Zhan, T Tang, C Ge, J Tan, M Xu
J. Nutr. Biochem., 2019;77(0):108253.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
DW2008S and its major constituents from Justicia procumbens exert anti-asthmatic effect via multitargeting activity
Authors: J Youm, H Lee, Y Choi, J Yoon
J. Cell. Mol. Med., 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Cross-Inhibition of Norrin and TGF-? Signaling Modulates Development of Retinal and Choroidal Vasculature
Authors: R Seitz, G Weber, S Albrecht, R Fuchshofer, ER Tamm, A Ohlmann
Invest. Ophthalmol. Vis. Sci., 2018;59(6):2240-2251.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Characterization and allergic role of IL-33-induced neutrophil polarization
Authors: B Sun, L Zhu, Y Tao, HX Sun, Y Li, P Wang, Y Hou, Y Zhao, X Zhang, L Zhang, N Na, Y Zhao
Cell. Mol. Immunol., 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
TGF-?-Induced CD8CD103Regulatory T Cells Show Potent Therapeutic Effect on Chronic Graft-versus-Host Disease Lupus by Suppressing B Cells
Authors: H Zhong, Y Liu, Z Xu, P Liang, H Yang, X Zhang, J Zhao, J Chen, S Fu, Y Tang, J Lv, J Wang, N Olsen, A Xu, SG Zheng
Front Immunol, 2018;9(0):35.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Interferon-gamma inhibits seminal plasma induction of colony stimulating factor 2 in mouse and human reproductive tract epithelial cells
Authors: DJ Sharkey, DJ Glynn, JE Schjenken, KP Tremellen, SA Robertson
Biol. Reprod., 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Differential Phagocytic Properties of CD45lowMicroglia and CD45highBrain Mononuclear Phagocytes-Activation and Age-Related Effects
Authors: S Rangaraju, SA Raza, NX Li, R Betarbet, EB Dammer, D Duong, JJ Lah, NT Seyfried, AI Levey
Front Immunol, 2018;9(0):405.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Fas Promotes T Helper 17 Cell Differentiation and Inhibits T Helper 1 Cell Development by Binding and Sequestering Transcription Factor STAT1
Authors: G Meyer Zu H, D Przybylski, MA Schramm, C Wang, A Schnell, Y Lee, R Sobel, A Regev, VK Kuchroo
Immunity, 2018;48(3):556-569.e7.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Collagen-derived peptides modulate CD4T-cell differentiation and suppress allergic responses in mice
Authors: A Nishikimi, YI Koyama, S Ishihara, S Kobayashi, C Tometsuka, M Kusubata, K Kuwaba, O Hayashida, S Hattori, K Katagiri
Immun Inflamm Dis, 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Celastrol mediates Th17 and Treg cell generation via metabolic signaling
Authors: J Zhang, J Shan, X Chen, S Li, D Long, Y Li
Biochem. Biophys. Res. Commun., 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Hedgehog Interacting Protein Promotes Fibrosis and Apoptosis in Glomerular Endothelial Cells in Murine Diabetes
Authors: XP Zhao, SY Chang, MC Liao, CS Lo, I Chenier, H Luo, JL Chiasson, JR Ingelfinge, JSD Chan, SL Zhang
Sci Rep, 2018;8(1):5958.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
ILDR2-Fc Is a Novel Regulator of Immune Homeostasis and Inducer of Antigen-Specific Immune Tolerance
Authors: JR Podojil, I Hecht, MY Chiang, I Vaknin, I Barbiro, A Novik, E Neria, G Rotman, SD Miller
J. Immunol., 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Comparing Effects of Transforming Growth Factor ?1 on Microglia From Rat and Mouse: Transcriptional Profiles and Potassium Channels
Authors: S Lively, D Lam, R Wong, LC Schlichter
Front Cell Neurosci, 2018;12(0):115.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Notch ligand Delta-like 4 induces epigenetic regulation of Treg cell differentiation and function in viral infection
Authors: HA Ting, D de Almeida, AJ Rasky, CA Malinczak, IP Maillard, MA Schaller, NW Lukacs
Mucosal Immunol, 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Fatty acid synthase is required for profibrotic TGF-? signaling
Authors: MY Jung, JH Kang, DM Hernandez, X Yin, M Andrianifa, Y Wang, A Gonzalez-G, AH Limper, R Lupu, EB Leof
FASEB J., 2018;0(0):fj201701187R.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Attenuation of pulmonary fibrosis in type I collagen-targeted reporter mice with ALK-5 inhibitors
Authors: H Terashima, M Aonuma, H Tsuchida, K Sugimoto, M Yokoyama, M Kato
Pulm Pharmacol Ther, 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Hexokinase II may be dispensable for CD4 T cell responses against a virus infection
Authors: SK Varanasi, U Jaggi, N Hay, BT Rouse
PLoS ONE, 2018;13(1):e0191533.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Mesenchymal stem cells ameliorate experimental arthritis via expression of interleukin-1 receptor antagonist
Authors: K Lee, N Park, H Jung, YA Rim, Y Nam, J Lee, SH Park, JH Ju
PLoS ONE, 2018;13(2):e0193086.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Elevated extracellular calcium ions promote proliferation and migration of mesenchymal stem cells via increasing osteopontin expression
Authors: MN Lee, HS Hwang, SH Oh, A Roshanzade, JW Kim, JH Song, ES Kim, JT Koh
Exp. Mol. Med., 2018;50(11):142.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
TRPV4 regulates matrix stiffness and TGF?1-induced epithelial-mesenchymal transition
Authors: S Sharma, R Goswami, DX Zhang, SO Rahaman
J. Cell. Mol. Med., 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Lung fibroblasts express a miR-19a-19b-20a sub-cluster to suppress TGF-?-associated fibroblast activation in murine pulmonary fibrosis
Authors: K Souma, S Shichino, S Hashimoto, S Ueha, T Tsukui, T Nakajima, HI Suzuki, FHW Shand, Y Inagaki, T Nagase, K Matsushima
Sci Rep, 2018;8(1):16642.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Co-transplantation of mesenchymal stem cells improves spermatogonial stem cell transplantation efficiency in mice
Authors: P Kadam, E Ntemou, Y Baert, S Van Laere, D Van Saen, E Goossens
Stem Cell Res Ther, 2018;9(1):317.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Microbiota-driven interleukin-17-producing cells and eosinophils synergize to accelerate multiple myeloma progression
Authors: A Calcinotto, A Brevi, M Chesi, R Ferrarese, L Garcia Per, M Grioni, S Kumar, VM Garbitt, ME Sharik, KJ Henderson, G Tonon, M Tomura, Y Miwa, E Esplugues, RA Flavell, S Huber, F Canducci, VS Rajkumar, PL Bergsagel, M Bellone
Nat Commun, 2018;9(1):4832.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
OX40 Costimulation Inhibits Foxp3 Expression and Treg Induction via BATF3-Dependent and Independent Mechanisms
Authors: X Zhang, X Xiao, P Lan, J Li, Y Dou, W Chen, N Ishii, S Chen, B Xia, K Chen, E Taparowsky, XC Li
Cell Rep, 2018;24(3):607-618.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Reduced production of laminin by hepatic stellate cells contributes to impairment in oval cell response to liver injury in aged mice
Authors: L Qian, H Zhang, Y Gu, D Li, S He, H Wang, Y Cheng, W Yang, H Yu, X Zhao, W Cai, L Meng, M Jin, Y Wang, Y Zhang
Aging (Albany NY), 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Rab4b Deficiency in T Cells Promotes Adipose Treg/Th17 Imbalance, Adipose Tissue Dysfunction, and Insulin Resistance
Authors: J Gilleron, G Bouget, S Ivanov, C Meziat, F Ceppo, B Vergoni, M Djedaini, A Soprani, K Dumas, A Jacquel, L Yvan-Charv, N Venteclef, JF Tanti, M Cormont
Cell Rep, 2018;25(12):3329-3341.e5.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Transforming growth factor-?1 up-regulates connexin43 expression in osteocytes via canonical Smad-dependent signaling pathway
Authors: W Liu, Y Cui, J Sun, L Cai, J Xie, X Zhou
Biosci. Rep., 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Leukotriene B4 promotes neovascularization and macrophage recruitment in murine wet-type AMD models
Authors: F Sasaki, T Koga, M Ohba, K Saeki, T Okuno, K Ishikawa, T Nakama, S Nakao, S Yoshida, T Ishibashi, H Ahmadieh, MR Kanavi, A Hafezi-Mog, JM Penninger, KH Sonoda, T Yokomizo
JCI Insight, 2018;3(18):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
GLK-IKK? signaling induces dimerization and translocation of the AhR-ROR?t complex in IL-17A induction and autoimmune disease
Authors: HC Chuang, CY Tsai, CH Hsueh, TH Tan
Sci Adv, 2018;4(9):eaat5401.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The shieldin complex mediates 53BP1-dependent DNA repair
Authors: SM Noordermee, S Adam, D Setiaputra, M Barazas, SJ Pettitt, AK Ling, M Olivieri, A Álvarez-Qu, N Moatti, M Zimmermann, S Annunziato, DB Krastev, F Song, I Brandsma, J Frankum, R Brough, A Sherker, S Landry, RK Szilard, MM Munro, A McEwan, T Goullet de, ZY Lin, T Hart, J Moffat, AC Gingras, A Martin, H van Attiku, J Jonkers, CJ Lord, S Rottenberg, D Durocher
Nature, 2018;560(7716):117-121.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Galectin-9 is Critical for Mucosal Adaptive Immunity through the TH17-IgA Axis
Authors: CC Liang, CS Li, IC Weng, HY Chen, HH Lu, CC Huang, FT Liu
Am. J. Pathol., 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Intraperitoneal infusion of mesenchymal stem cell attenuates severity of collagen antibody induced arthritis
Authors: Y Nam, SM Jung, YA Rim, H Jung, K Lee, N Park, J Kim, Y Jang, YB Park, SH Park, JH Ju
PLoS ONE, 2018;13(6):e0198740.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
RAGE Deletion Confers Renoprotection by Reducing Responsiveness to Transforming Growth Factor-? and Increasing Resistance to Apoptosis
Authors: S Hagiwara, K Sourris, M Ziemann, W Tieqiao, M Mohan, AD McClelland, E Brennan, J Forbes, M Coughlan, B Harcourt, S Penfold, B Wang, G Higgins, R Pickering, A El-Osta, MC Thomas, ME Cooper, P Kantharidi
Diabetes, 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Neer Award 2018: Platelet-derived growth factor receptor α co-expression typifies a subset of platelet-derived growth factor receptor β-positive progenitor cells that contribute to fatty degeneration and fibrosis of the murine rotator cuff
Authors: AR Jensen, BV Kelley, GM Mosich, A Ariniello, CD Eliasberg, B Vu, P Shah, SK Devana, IR Murray, B Péault, A Dar, FA Petriglian
J Shoulder Elbow Surg, 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The H2B deubiquitinase Usp22 promotes antibody class switch recombination by facilitating non-homologous end joining
Authors: C Li, T Irrazabal, CC So, M Berru, L Du, E Lam, AK Ling, JL Gommerman, Q Pan-Hammar, A Martin
Nat Commun, 2018;9(1):1006.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Tumor-Induced Generation of Splenic Erythroblast-like Ter-Cells Promotes Tumor Progression
Authors: Y Han, Q Liu, J Hou, Y Gu, Y Zhang, Z Chen, J Fan, W Zhou, S Qiu, Y Zhang, T Dong, N Li, Z Jiang, H Zhu, Q Zhang, Y Ma, L Zhang, Q Wang, Y Yu, N Li, X Cao
Cell, 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
DNA double-strand break response factors influence end-joining features of IgH class switch and general translocation junctions
Authors: RA Panchaksha, X Zhang, V Kumar, Z Du, PC Wei, J Kao, J Dong, FW Alt
Proc. Natl. Acad. Sci. U.S.A., 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Transcription factor scleraxis vitally contributes to progenitor lineage direction in wound healing of adult tendon in mice
Authors: T Sakabe, K Sakai, T Maeda, A Sunaga, N Furuta, R Schweitzer, T Sasaki, T Sakai
J. Biol. Chem., 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Signaling via Smad2 and Smad3 is dispensable for adult murine hematopoietic stem cell function in vivo
Authors: M Billing, E Rörby, M Dahl, U Blank, S Andradottí, MM Matzuk, M Ehinger, S Karlsson
Exp. Hematol., 2017;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
BJ-2266 ameliorates experimental autoimmune encephalomyelitis through down-regulation of the JAK/STAT signaling pathway
Authors: Z You, M Timilshina, BS Jeong, JH Chang
Eur. J. Immunol., 2017;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Estrogen modulates mesenchymal-epidermal interactions in the adult nipple
Authors: HJ Wu, JW Oh, DF Spandau, S Tholpady, J Diaz, LJ Schroeder, CD Offutt, AB Glick, MV Plikus, S Koyama, J Foley
Development, 2017;0(0):.
Species: Mouse
Sample Types: Complex Sample Type
Applications: In Vivo -
Interleukin 4 receptor-targeted pro-apoptotic peptide blocks tumor growth and metastasis by enhancing anti-tumor immunity
Authors: SMP Vadevoo, JE Kim, GR Gunassekar, HK Jung, L Chi, DE Kim, SH Lee, SH Im, B Lee
Mol. Cancer Ther., 2017;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
BJ-1108, a 6-Amino-2,4,5-trimethylpyridin-3-ol analogue, regulates differentiation of Th1 and Th17 cells to ameliorate experimental autoimmune encephalomyelitis
Authors: Y Kang, M Timilshina, TG Nam, BS Jeong, JH Chang
Biol. Res, 2017;50(1):8.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
TLR7 Signaling Regulates Th17 Cells and Autoimmunity: Novel Potential for Autoimmune Therapy
Authors: J Ye, Y Wang, X Liu, L Li, A Opejin, EC Hsueh, H Luo, T Wang, D Hawiger, G Peng
J. Immunol., 2017;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
CD73 promotes resistance to HER2/ErbB2 antibody therapy
Authors: M Turcotte, D Allard, D Mittal, Y Bareche, L Buisseret, V Jose, S Pommey, V Delisle, S Loi, H Joensuu, PL Kellokumpu, C Sotiriou, MJ Smyth, J Stagg
Cancer Res., 2017;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Interferon-gamma regulates inflammatory cell death by targeting necroptosis in experimental autoimmune arthritis
Authors: SH Lee, JY Kwon, SY Kim, K Jung, ML Cho
Sci Rep, 2017;7(1):10133.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Nuclear Proximity of Mtr4 to RNA Exosome Restricts DNA Mutational Asymmetry
Authors: J Lim, PK Giri, D Kazadi, B Laffleur, W Zhang, V Grinstein, E Pefanis, LM Brown, E Ladewig, O Martin, Y Chen, R Rabadan, F Boyer, G Rothschild, M Cogné, E Pinaud, H Deng, U Basu
Cell, 2017;169(3):523-537.e15.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Balanced Bcl-3 expression in murine CD4(+) T cells is required for generation of encephalitogenic Th17 cells
Authors: IA Mufazalov, J Kuschmann, D Andruszews, J Masri, LA Gabriel, P Adams, S Reissig, N Hövelmeyer, A Waisman
Eur. J. Immunol., 2017;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Local Inflammatory Cues Regulate Differentiation and Persistence of CD8(+) Tissue-Resident Memory T Cells
Authors: T Bergsbaken, MJ Bevan, PJ Fink
Cell Rep, 2017;19(1):114-124.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Bone-induced expression of integrin ?3 enables targeted nanotherapy of breast cancer metastases
Authors: MH Ross, AK Esser, GC Fox, AH Schmieder, X Yang, G Hu, D Pan, X Su, Y Xu, DV Novack, T Walsh, GA Colditz, GH Lukaszewic, E Cordell, JS Novack, JAJ Fitzpatric, DL Waning, KS Mohammad, TA Guise, GM Lanza, KN Weilbaeche
Cancer Res., 2017;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The excretory-secretory products of Echinococcus granulosus protoscoleces directly regulate the differentiation of B10, B17 and Th17 cells
Authors: W Pan, WT Hao, YJ Shen, XY Li, YJ Wang, FF Sun, JH Yin, J Zhang, RX Tang, JP Cao, KY Zheng
Parasit Vectors, 2017;10(1):348.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The long non-coding RNA GAS5 regulates TGF-?-induced smooth muscle cell differentiation via RNA-Smad binding element
Authors: R Tang, G Zhang, YC Wang, X Mei, SY Chen
J. Biol. Chem., 2017;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
IL-23 restoration of Th17 effector function is independent of IL-6 and TGF-? in a mouse model of alcohol and burn injury
Authors: X Li, AR Cannon, AM Hammer, NL Morris, MA Choudhry
J. Leukoc. Biol., 2017;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Inhibiting Oxidative Phosphorylation In Vivo Restrains Th17 Effector Responses and Ameliorates Murine Colitis
Authors: L Franchi, I Monteleone, LY Hao, MA Spahr, W Zhao, X Liu, K Demock, A Kulkarni, CA Lesch, B Sanchez, L Carter, I Marafini, X Hu, O Mashadova, M Yuan, JM Asara, H Singh, CA Lyssiotis, G Monteleone, AW Opipari, GD Glick
J. Immunol, 2017;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Follistatin like-1 (Fstl1) is required for the normal formation of lung airway and vascular smooth muscle at birth
Authors: X Liu, Y Liu, X Li, J Zhao, Y Geng, W Ning
PLoS ONE, 2017;12(6):e0177899.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Bi-layered constructs of poly(glycerol-sebacate)-?-tricalcium phosphate for bone-soft tissue interface applications
Authors: Atakan Tevlek
Mater Sci Eng C Mater Biol Appl, 2017;72(0):316-324.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
mTORC2 controls Th9 polarization and allergic airway inflammation
Authors: H Chen, L Zhang, P Wang, H Su, W Wang, Z Chu, L Zhang, X Zhang, Y Zhao
Allergy, 2017;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Pirfenidone attenuates bleomycin-induced pulmonary fibrosis in mice by regulating Nrf2/Bach1 equilibrium
Authors: Y Liu, F Lu, L Kang, Z Wang, Y Wang
BMC Pulm Med, 2017;17(1):63.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The frequency of Th17�cells in the small intestine exhibits a day-night variation dependent on circadian clock activity
Authors: HP Thu Le, Y Nakamura, K Oh-Oka, K Ishimaru, S Nakajima, A Nakao
Biochem. Biophys. Res. Commun., 2017;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Lamtor1 Is Critically Required for CD4(+) T Cell Proliferation and Regulatory T Cell Suppressive Function
Authors: T Hosokawa, T Kimura, S Nada, T Okuno, D Ito, S Kang, S Nojima, K Yamashita, T Nakatani, Y Hayama, Y Kato, Y Kinehara, M Nishide, N Mikami, S Koyama, H Takamatsu, D Okuzaki, N Ohkura, S Sakaguchi, M Okada, A Kumanogoh
J. Immunol., 2017;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Suppression of Th17 cell differentiation by misshapen/NIK-related kinase MINK1
Authors: G Fu, Q Xu, Y Qiu, X Jin, T Xu, S Dong, J Wang, Y Ke, H Hu, X Cao, D Wang, H Cantor, X Gao, L Lu
J. Exp. Med., 2017;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
NLRP3 signaling drives macrophage-induced adaptive immune suppression in pancreatic carcinoma
Authors: D Daley, VR Mani, N Mohan, N Akkad, GSDB Pandian, S Savadkar, KB Lee, A Torres-Her, B Aykut, B Diskin, W Wang, MS Farooq, AI Mahmud, G Werba, EJ Morales, S Lall, BJ Wadowski, AG Rubin, ME Berman, R Narayanan, M Hundeyin, G Miller
J. Exp. Med., 2017;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Suppressive IL-17A(+)Foxp3(+) and ex-Th17 IL-17A(neg)Foxp3(+) Treg cells are a source of tumour-associated Treg cells
Authors: S Downs-Cann, S Berkey, GM Delgoffe, RP Edwards, T Curiel, K Odunsi, DL Bartlett, N Obermajer
Nat Commun, 2017;8(0):14649.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The Kielin/chordin-like Protein (KCP) Attenuates High Fat Diet Induced Obesity and Metabolic Syndrome in Mice
Authors: A Soofi, KI Wolf, MP Emont, N Qi, G Martinez-S, E Grimley, W Ostwani, GR Dressler
J. Biol. Chem., 2017;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Notch Balances Th17 and Induced Regulatory T Cell Functions in Dendritic Cells by Regulating Aldh1a2 Expression
Authors: TS Zaman, H Arimochi, S Maruyama, C Ishifune, SI Tsukumo, A Kitamura, K Yasutomo
J. Immunol., 2017;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Selective degradation of PU.1 during autophagy represses the differentiation and antitumour activity of TH9 cells
Authors: T Rivera Var, Z Cai, Y Shen, M Dosset, I Benoit-Liz, T Martin, A Roussey, RA Flavell, F Ghiringhel, L Apetoh
Nat Commun, 2017;8(1):559.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Manipulating Glucose Metabolism during Different Stages of Viral Pathogenesis Can Have either Detrimental or Beneficial Effects
Authors: SK Varanasi, D Donohoe, U Jaggi, BT Rouse
J. Immunol., 2017;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Wolf-Hirschhorn Syndrome Candidate 1 Is Necessary for Correct Hematopoietic and B Cell Development
Authors: E Campos-San, N Deleyto-Se, V Dominguez, E Carrillo-d, K Ura, PP Rocha, J Kim, A Aljoufi, A Esteve-Cod, M Dabad, M Gut, H Heyn, Y Kaneda, K Nimura, JA Skok, ML Martinez-F, C Cobaleda
Cell Rep, 2017;19(8):1586-1601.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
CYP4A in tumor-associated macrophages promotes pre-metastatic niche formation and metastasis
Authors: XW Chen, TJ Yu, J Zhang, Y Li, HL Chen, GF Yang, W Yu, YZ Liu, XX Liu, CF Duan, HL Tang, M Qiu, CL Wang, H Zheng, J Yue, AM Guo, J Yang
Oncogene, 2017;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Inhibition of ubiquitin-specific protease 34 (USP34) induces epithelial-mesenchymal transition and promotes stemness in mammary epithelial cells
Authors: E Oh, JY Kim, D Sung, Y Cho, N Lee, H An, YJ Kim, TM Cho, JH Seo
Cell. Signal., 2017;36(0):230-239.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Expression of antisense of microRNA-26a-5p in mesenchymal stem cells increases their therapeutic effects against cirrhosis
Authors: L Chen, W Zeng, B Yang, X Cui, C Feng, L Wang, H Wang, X Zhou, P Li, F Lv, T Li
Am J Transl Res, 2017;9(3):1500-1508.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Rad52 competes with Ku70/Ku86 for binding to S-region DSB ends to modulate antibody class-switch DNA recombination
Authors: H Zan, C Tat, Z Qiu, JR Taylor, JA Guerrero, T Shen, P Casali
Nat Commun, 2017;8(0):14244.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Mechanosignaling activation of TGF? maintains intervertebral disc homeostasis
Authors: Q Bian, L Ma, A Jain, JL Crane, K Kebaish, M Wan, Z Zhang, X Edward Guo, PD Sponseller, CA Séguin, LH Riley, Y Wang, X Cao
Bone Res, 2017;5(0):17008.
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay -
Absence of Notch1 in murine myeloid cells attenuates the development of experimental autoimmune encephalomyelitis by affecting Th1 and Th17 priming
Authors: M Fernández, EM Monsalve, S López-Lópe, A Ruiz-Garcí, S Mellado, E Caminos, JJ García-Ram, J Laborda, P Tranque, MJM Díaz-Guerr
Eur. J. Immunol., 2017;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Interleukin-17A-promoted MSC2 polarization related with new bone formation of ankylosing spondylitis
Authors: T He, Y Huang, C Zhang, D Liu, C Cheng, W Xu, X Zhang
Oncotarget, 2017;8(57):96993-97008.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Pharmacologic modulation of ROR?t translates to efficacy in preclinical and translational models of psoriasis and inflammatory arthritis
Sci Rep, 2016;6(0):37977.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Reduced TCR-dependent activation through citrullination of a T-cell epitope enhances Th17 development by disruption of the STAT3/5 balance
Eur J Immunol, 2016;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Restoration of Corneal Transparency by Mesenchymal Stem Cells.
Authors: Sharad K Mittal, Masahiro Omoto, Afsaneh Amouzegar, Anuradha Sahu, Alexandra Rezazadeh, Kishore R Katikired, Dhvanit I Shah, Srikant K Sahu, Sunil K Chauhan
Stem Cell Reports, 2016;0(0):2213-6711.
Species: Mouse
Sample Types: Transfected Whole Cells
Applications: Bioassay -
The role of ?-smooth muscle actin in fibroblast-mediated matrix contraction and remodeling
Authors: Nikolaos G Frangogian
Biochim. Biophys. Acta, 2016;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Beta 1-integrin ligation and TLR ligation enhance GM-CSF-induced ALDH1A2 expression in dendritic cells, but differentially regulate their anti-inflammatory properties
Sci Rep, 2016;6(0):37914.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Autonomous membrane IgE signaling prevents IgE-memory formation
Nat Immunol, 2016;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Attenuation of PKR-like ER Kinase (PERK) Signaling Selectively Controls Endoplasmic Reticulum Stress-induced Inflammation Without Compromising Immunological Responses
Authors: LN Guthrie, K Abiraman, ES Plyler, NT Sprenkle, SA Gibson, BC McFarland, R Rajbhandar, AL Rowse, EN Benveniste, GP Meares
J. Biol. Chem., 2016;291(30):15830-40.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
SiRNA-mediated in vivo gene knockdown by acid-degradable cationic nanohydrogel particles
Authors: Nadine Leber
J Control Release, 2016;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Vimentin coordinates fibroblast proliferation and keratinocyte differentiation in wound healing via TGF-?-Slug signaling
Proc Natl Acad Sci USA, 2016;113(30):E4320-7.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
All Trans Retinoic Acid, Transforming Growth Factor ? and Prostaglandin E2 in Mouse Plasma Synergize with Basophil-Secreted Interleukin-4 to M2 Polarize Murine Macrophages
PLoS ONE, 2016;11(12):e0168072.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Leptin directly promotes T-cell glycolytic metabolism to drive effector T-cell differentiation in a mouse model of autoimmunity
Eur J Immunol, 2016;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Alternative splicing of MALT1 controls signalling and activation of CD4(+) T cells
Authors: I Meininger, RA Griesbach, D Hu, T Gehring, T Seeholzer, A Bertossi, J Kranich, A Oeckinghau, AC Eitelhuber, U Greczmiel, A Gewies, M Schmidt-Su, J Ruland, T Brocker, V Heissmeyer, F Heyd, D Krappmann
Nat Commun, 2016;7(0):11292.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Restoration of Corneal Transparency by Mesenchymal Stem Cells
Stem Cell Reports, 2016;7(4):583-590.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Young microglia restore amyloid plaque clearance of aged microglia
Authors: Anna Daria
EMBO J, 2016;0(0):.
Species: Mouse
Sample Types: Complex Sample Type
Applications: Bioassay -
Pharmacologic inhibition of Hsp90 to prevent GLT-1 degradation as an effective therapy for epilepsy
Authors: Longze Sha
J. Exp. Med, 2016;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Absence of miR-146a in podocytes increases risk of diabetic glomerulopathy via upregulation of erbb4 and notch-1
Authors: Ha Won Lee
J. Biol. Chem, 2016;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
T cells are necessary for ILC2 activation in house dust mite-induced allergic airway inflammation in mice
Authors: BW Li, MJ de Bruijn, I Tindemans, M Lukkes, A KleinJan, HC Hoogsteden, RW Hendriks
Eur J Immunol, 2016;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Treatment of refractory cutaneous ulcers with mixed sheets consisting of peripheral blood mononuclear cells and fibroblasts
Authors: Koji Ueno
Sci Rep, 2016;6(0):28538.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Differential effects of Pax3 on expression of polysialyltransferases STX and PST in TGF-?-treated normal murine mammary gland cells
Exp Biol Med (Maywood), 2016;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
GLUT-1-Dependent Glycolysis is Increased During Aging-related Lung Fibrosis and Phloretin Inhibits Lung Fibrosis
Authors: Soo Jung Cho
Am. J. Respir. Cell Mol. Biol, 2016;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Th1 cells downregulate connexin 43 gap junctions in astrocytes via microglial activation
Sci Rep, 2016;6(0):38387.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
CD8+ T Cells and Endogenous IL-10 Are Required for Resolution of Chemotherapy-Induced Neuropathic Pain
Authors: Annemieke Kavelaars
J. Neurosci., 2016;36(43):11074-11083.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Classical transient receptor potential 6 (TRPC6) channels support myofibroblast differentiation and development of experimental pulmonary fibrosis
Authors: Katharina Hofmann
Biochim. Biophys. Acta, 2016;1863(2):560-568.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Affinity for self antigen selects Treg cells with distinct functional properties
Nat Immunol, 2016;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition
Authors: Cédric Blanpain
Cell Stem Cell, 2016;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Itk signals promote neuroinflammation by regulating CD4+ T-cell activation and trafficking.
Authors: Kannan A, Kim D, August A, Bynoe M
J Neurosci, 2015;35(1):221-33.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iTreg cell balance.
Authors: Basu R, Whitley S, Bhaumik S, Zindl C, Schoeb T, Benveniste E, Pear W, Hatton R, Weaver C
Nat Immunol, 2015;16(3):286-95.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Blocking follistatin-like 1 attenuates bleomycin-induced pulmonary fibrosis in mice.
Authors: Dong Y, Geng Y, Li L, Li X, Yan X, Fang Y, Li X, Dong S, Liu X, Li X, Yang X, Zheng X, Xie T, Liang J, Dai H, Liu X, Yin Z, Noble P, Jiang D, Ning W
J Exp Med, 2015;212(2):235-52.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Mesenchymal stem/stromal cells protect against autoimmunity via CCL2-dependent recruitment of myeloid-derived suppressor cells.
Authors: Lee H, Ko J, Jeong H, Ko A, Kim M, Wee W, Yoon S, Oh J
J Immunol, 2015;194(8):3634-45.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
ShcA regulates late stages of T cell development and peripheral CD4+ T cell numbers.
Authors: Buckley M, Trampont P, Arandjelovic S, Fond A, Juncadella I, Ravichandran K
J Immunol, 2015;194(4):1665-76.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Impaired dendritic cell function in a spontaneous autoimmune polyneuropathy.
Authors: Quan S, Kim H, Dukala D, Sheng J, Soliven B
J Immunol, 2015;194(9):4175-84.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Dendritic cell SIRT1-HIF1alpha axis programs the differentiation of CD4+ T cells through IL-12 and TGF-beta1.
Authors: Liu G, Bi Y, Xue L, Zhang Y, Yang H, Chen X, Lu Y, Zhang Z, Liu H, Wang X, Wang R, Chu Y, Yang R
Proc Natl Acad Sci U S A, 2015;112(9):E957-65.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Myocardin-related transcription factors control the motility of epicardium-derived cells and the maturation of coronary vessels.
Authors: Trembley M, Velasquez L, de Mesy Bentley K, Small E
Development, 2015;142(1):21-30.
-
Testosterone suppresses hepatic inflammation by the downregulation of IL-17, CXCL-9, and CXCL-10 in a mouse model of experimental acute cholangitis.
Authors: Schwinge D, Carambia A, Quaas A, Krech T, Wegscheid C, Tiegs G, Prinz I, Lohse A, Herkel J, Schramm C
J Immunol, 2015;194(6):2522-30.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Beclin 1 regulates neuronal transforming growth factor-beta signaling by mediating recycling of the type I receptor ALK5.
Authors: O'Brien C, Bonanno L, Zhang H, Wyss-Coray T
Mol Neurodegener, 2015;10(1):69.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Long non-coding RNAs (LncRNA) regulated by transforming growth factor (TGF) beta: LncRNA-hit-mediated TGFbeta-induced epithelial to mesenchymal transition in mammary epithelia.
Authors: Richards E, Zhang G, Li Z, Permuth-Wey J, Challa S, Li Y, Kong W, Dan S, Bui M, Coppola D, Mao W, Sellers T, Cheng J
J Biol Chem, 2015;290(11):6857-67.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Retinoic acid can exacerbate T cell intrinsic TLR2 activation to promote tolerance.
Authors: Nguyen, Vivien, Pearson, Kandyce, Kim, Jee-Hyun, Kamdar, Karishma, DePaolo, R Willia
PLoS ONE, 2015;10(3):e0118875.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Monocyte Chemoattractant Protein-Induced Protein 1 (MCPIP1) Enhances Angiogenic and Cardiomyogenic Potential of Murine Bone Marrow-Derived Mesenchymal Stem Cells.
Authors: Labedz-Maslowska A, Lipert B, Berdecka D, Kedracka-Krok S, Jankowska U, Kamycka E, Sekula M, Madeja Z, Dawn B, Jura J, Zuba-Surma E
PLoS ONE, 2015;10(7):e0133746.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Regulatory T cell reprogramming toward a Th2-cell-like lineage impairs oral tolerance and promotes food allergy.
Authors: Noval Rivas M, Burton O, Wise P, Charbonnier L, Georgiev P, Oettgen H, Rachid R, Chatila T
Immunity, 2015;42(3):512-23.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Novel mechanism of macrophage-mediated metastasis revealed in a zebrafish model of tumor development.
Authors: Wang J, Cao Z, Zhang X, Nakamura M, Sun M, Hartman J, Harris R, Sun Y, Cao Y
Cancer Res, 2015;75(2):306-15.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
A functional polymorphism of Ptpn22 is associated with type 1 diabetes in the BioBreeding rat.
Authors: Sarmiento J, Wallis R, Ning T, Marandi L, Chao G, Veillette A, Lernmark A, Paterson A, Poussier P
J Immunol, 2015;194(2):615-29.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay -
miR-148a is upregulated by Twist1 and T-bet and promotes Th1-cell survival by regulating the proapoptotic gene Bim.
Authors: Haftmann C, Stittrich A, Zimmermann J, Fang Z, Hradilkova K, Bardua M, Westendorf K, Heinz G, Riedel R, Siede J, Lehmann K, Weinberger E, Zimmel D, Lauer U, Haupl T, Sieper J, Backhaus M, Neumann C, Hoffmann U, Porstner M, Chen W, Grun J, Baumgrass R, Matz M, Lohning M, Scheffold A, Wittmann J, Chang H, Rajewsky N, Jack H, Radbruch A, Mashreghi M
Eur J Immunol, 2015;45(4):1192-205.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros-derived hematopoietic stem cells.
Authors: Hadland B, Varnum-Finney B, Poulos M, Moon R, Butler J, Rafii S, Bernstein I
J Clin Invest, 2015;125(5):2032-45.
Species: Mouse
Sample Types: Protein
Applications: Bioassay -
Matrix metalloproteinase-9 deficiency attenuates diabetic nephropathy by modulation of podocyte functions and dedifferentiation.
Authors: Li S, Huang P, Yang A, Tarng D, Yang W, Lin C, Chen J, Schmid-Schonbein G, Lin S
Kidney Int, 2014;86(2):358-69.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The hippo pathway effector Yap controls patterning and differentiation of airway epithelial progenitors.
Authors: Mahoney J, Mori M, Szymaniak A, Varelas X, Cardoso W
Dev Cell, 2014;30(2):137-50.
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay -
Unexpected phenotype of mice lacking Shcbp1, a protein induced during T cell proliferation.
Authors: Buckley M, Arandjelovic S, Trampont P, Kim T, Braciale T, Ravichandran K
PLoS ONE, 2014;9(8):e105576.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Retinoic acid prevents mesenteric lymph node dendritic cells from inducing IL-13-producing inflammatory Th2 cells.
Authors: Yokota-Nakatsuma A, Takeuchi H, Ohoka Y, Kato C, Song S, Hoshino T, Yagita H, Ohteki T, Iwata M
Mucosal Immunol, 2014;7(4):786-801.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Tracking the elusive fibrocyte: identification and characterization of collagen-producing hematopoietic lineage cells during murine wound healing.
Authors: Suga H, Rennert R, Rodrigues M, Sorkin M, Glotzbach J, Januszyk M, Fujiwara T, Longaker M, Gurtner G
Stem Cells, 2014;32(5):1347-60.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Laminin alpha1 regulates age-related mesangial cell proliferation and mesangial matrix accumulation through the TGF-beta pathway.
Authors: Ning L, Kurihara H, de Vega S, Ichikawa-Tomikawa N, Xu Z, Nonaka R, Kazuno S, Yamada Y, Miner J, Arikawa-Hirasawa E
Am J Pathol, 2014;184(6):1683-94.
Species: Mouse
Sample Types: N/A
Applications: ELISA Developmet -
A Snail1/Notch1 signalling axis controls embryonic vascular development.
Authors: Wu Z, Rowe R, Lim K, Lin Y, Willis A, Tang Y, Li X, Nor J, Maillard I, Weiss S
Nat Commun, 2014;5(0):3998.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Lnk/Sh2b3 controls the production and function of dendritic cells and regulates the induction of IFN-gamma-producing T cells.
Authors: Mori T, Iwasaki Y, Seki Y, Iseki M, Katayama H, Yamamoto K, Takatsu K, Takaki S
J Immunol, 2014;193(4):1728-36.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Blockade of IL-33 release and suppression of type 2 innate lymphoid cell responses by helminth secreted products in airway allergy.
Authors: McSorley H, Blair N, Smith K, McKenzie A, Maizels R
Mucosal Immunol, 2014;7(5):1068-78.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Elongated TCR alpha chain CDR3 favors an altered CD4 cytokine profile.
Authors: Reynolds C, Chong D, Raynsford E, Quigley K, Kelly D, Llewellyn-Hughes J, Altmann D, Boyton R
BMC Biol, 2014;12(0):32.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Toll-like receptor 9 mediated responses in cardiac fibroblasts.
Authors: Ohm I, Alfsnes K, Belland Olsen M, Ranheim T, Sandanger O, Dahl T, Aukrust P, Finsen A, Yndestad A, Vinge L
PLoS ONE, 2014;9(8):e104398.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Integrin-mediated type II TGF-beta receptor tyrosine dephosphorylation controls SMAD-dependent profibrotic signaling.
Authors: Chen X, Wang H, Liao H, Hu W, Gewin L, Mernaugh G, Zhang S, Zhang Z, Vega-Montoto L, Vanacore R, Fassler R, Zent R, Pozzi A
J Clin Invest, 2014;124(8):3295-310.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
HIV Nef expression favors the relative preservation of CD4+ T regulatory cells that retain some important suppressive functions.
Authors: Chrobak P, Afkhami S, Priceputu E, Poudrier J, Meunier C, Hanna Z, Sparwasser T, Jolicoeur P
J Immunol, 2014;192(4):1681-92.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Attenuation of experimental colitis in glutathione peroxidase 1 and catalase double knockout mice through enhancing regulatory T cell function.
Authors: Kim H, Lee A, Choi E, Kie J, Lim W, Lee H, Moon B, Seoh J
PLoS ONE, 2014;9(4):e95332.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment.
Authors: Seth A, Ye J, Yu N, Guez F, Bedford D, Neale G, Cordi S, Brindle P, Lemaigre F, Kaestner K, Sosa-Pineda B
Development, 2014;141(3):538-47.
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay -
The alarmin IL-33 promotes regulatory T-cell function in the intestine.
Authors: Schiering C, Krausgruber T, Chomka A, Frohlich A, Adelmann K, Wohlfert E, Pott J, Griseri T, Bollrath J, Hegazy A, Harrison O, Owens B, Lohning M, Belkaid Y, Fallon P, Powrie F
Nature, 2014;513(7519):564-8.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Real-time imaging of the epithelial-mesenchymal transition using microRNA-200a sequence-based molecular beacon-conjugated magnetic nanoparticles.
Authors: Choi Y, Kim H, Woo J, Hwang E, Cho K, Kim S, Moon W
PLoS ONE, 2014;9(7):e102164.
Species: Canine
Sample Types: Whole Cells
Applications: Bioassay -
Myostatin stimulates, not inihibits, C2C12 myoblast proliferation.
Authors: Rodgers B, Wiedeback B, Hoversten K, Jackson M, Walker R, Thompson T
Endocrinology, 2014;155(3):670-5.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
TGF-beta and opioid receptor signaling crosstalk results in improvement of endogenous and exogenous opioid analgesia under pathological pain conditions.
Authors: Lantero A, Tramullas M, Pilar-Cuellar F, Valdizan E, Santillan R, Roques B, Hurle M
J Neurosci, 2014;34(15):5385-95.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Molecular and cellular features of murine craniofacial and trunk neural crest cells as stem cell-like cells.
Authors: Hagiwara, Kunie, Obayashi, Takeshi, Sakayori, Nobuyuki, Yamanishi, Emiko, Hayashi, Ryuhei, Osumi, Noriko, Nakazawa, Toru, Nishida, Kohji
PLoS ONE, 2014;9(1):e84072.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Brain glycolipids suppress T helper cells and inhibit autoimmune demyelination.
Authors: Mycko M, Sliwinska B, Cichalewska M, Cwiklinska H, Raine C, Selmaj K
J Neurosci, 2014;34(25):8646-58.
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Alternative splice variants of AID are not stoichiometrically present at the protein level in chronic lymphocytic leukemia.
Authors: Rebhandl S, Huemer M, Zaborsky N, Gassner F, Catakovic K, Felder T, Greil R, Geisberger R
Eur J Immunol, 2014;44(7):2175-87.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The transcription factor IRF8 activates integrin-mediated TGF-beta signaling and promotes neuroinflammation.
Authors: Yoshida Y, Yoshimi R, Yoshii H, Kim D, Dey A, Xiong H, Munasinghe J, Yazawa I, O'Donovan M, Maximova O, Sharma S, Zhu J, Wang H, Morse H, Ozato K
Immunity, 2014;40(2):187-98.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Siah2 regulates tight junction integrity and cell polarity through control of ASPP2 stability.
Authors: Kim H, Claps G, Moller A, Bowtell D, Lu X, Ronai Z
Oncogene, 2014;33(15):2004-10.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
IL-21 induces IL-22 production in CD4+ T cells.
Authors: Yeste A, Mascanfroni I, Nadeau M, Burns E, Tukpah A, Santiago A, Wu C, Patel B, Kumar D, Quintana F
Nat Commun, 2014;5(0):3753.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Hepatocytes induce Foxp3(+) regulatory T cells by Notch signaling.
Authors: Burghardt S, Claass B, Erhardt A, Karimi K, Tiegs G
J Leukoc Biol, 2014;96(4):571-7.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Cell-extrinsic CTLA4-mediated regulation of dendritic cell maturation depends on STAT3.
Authors: Kowalczyk A, D'Souza C, Zhang L
Eur J Immunol, 2014;44(4):1143-55.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The loss of Trps1 suppresses ureteric bud branching because of the activation of TGF-beta signaling.
Authors: Gui T, Sun Y, Gai Z, Shimokado A, Muragaki Y, Zhou G
Dev Biol, 2013;377(2):415-27.
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay -
Distinctive subdomains in the resorbing surface of osteoclasts.
Authors: Szewczyk K, Fuller K, Chambers T
PLoS ONE, 2013;8(3):e60285.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
TNF-alpha promotes cerebral pericyte remodeling in vitro, via a switch from alpha1 to alpha2 integrins.
Authors: Tigges U, Boroujerdi A, Welser-Alves J, Milner R
J Neuroinflammation, 2013;10(0):33.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Interferon gamma suppresses collagen-induced arthritis by regulation of Th17 through the induction of indoleamine-2,3-deoxygenase.
Authors: Lee J, Lee J, Park M, Lim M, Park E, Kim E, Yang E, Lee S, Jhun J, Park S, Kim H, Cho M
PLoS ONE, 2013;8(4):e60900.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Endothelial dysfunction exacerbates renal interstitial fibrosis through enhancing fibroblast Smad3 linker phosphorylation in the mouse obstructed kidney.
Authors: Sun Y, Qu X, Li X, Nikolic-Paterson D, Li J
PLoS ONE, 2013;8(12):e84063.
Species: Rat
Sample Types: Whole Cells
Applications: Cell Culture -
Control of T helper 2 responses by transcription factor IRF4-dependent dendritic cells.
Authors: Gao Y, Nish S, Jiang R, Hou L, Licona-Limon P, Weinstein J, Zhao H, Medzhitov R
Immunity, 2013;39(4):722-32.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Thrombospondin-1 induction in the diabetic myocardium stabilizes the cardiac matrix in addition to promoting vascular rarefaction through angiopoietin-2 upregulation.
Authors: Gonzalez-Quesada C, Cavalera M, Biernacka A, Kong P, Lee D, Saxena A, Frunza O, Dobaczewski M, Shinde A, Frangogiannis N
Circ Res, 2013;113(12):1331-44.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
FAK-related nonkinase is a multifunctional negative regulator of pulmonary fibrosis.
Authors: Ding Q, Cai G, Hu M, Yang Y, Zheng A, Tang Q, Gladson C, Hayasaka H, Wu H, You Z, Southern B, Grove L, Rahaman S, Fang H, Olman M
Am J Pathol, 2013;182(5):1572-84.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Activation of PPAR-alpha induces cell cycle arrest and inhibits transforming growth factor-beta1 induction of smooth muscle cell phenotype in 10T1/2 mesenchymal cells.
Authors: Lien S, Wei S, Chang S, Chang M, Chang J, Chiu J
Cell Signal, 2013;25(5):1252-63.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Exposure to atmospheric particulate matter enhances Th17 polarization through the aryl hydrocarbon receptor.
Authors: van Voorhis, Michael, Knopp, Samantha, Julliard, Walker, Fechner, John H, Zhang, Xiaoji, Schauer, James J, Mezrich, Joshua D
PLoS ONE, 2013;8(12):e82545.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Integration of multiple signaling regulates through apoptosis the differential osteogenic potential of neural crest-derived and mesoderm-derived Osteoblasts.
Authors: Li S, Meyer N, Quarto N, Longaker M
PLoS ONE, 2013;8(3):e58610.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
IL-4/IL-13-dependent and independent expression of miR-124 and its contribution to M2 phenotype of monocytic cells in normal conditions and during allergic inflammation.
Authors: Veremeyko, Tatyana, Siddiqui, Shafiudd, Sotnikov, Ilya, Yung, Amanda, Ponomarev, Eugene D
PLoS ONE, 2013;8(12):e81774.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Regulation of innate CD8+ T-cell activation mediated by cytokines.
Proc Natl Acad Sci U S A, 2012;109(25):9971-6.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay
FAQs
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Can I reconstitute Recombinant Mouse TGF beta 1 Protein (Catalog # 7666-MB or 7666-MB/CF) in PBS or water?
Recombinant Mouse TGF beta 1 Protein (Catalog # 7666-MB or 7666-MB/CF) needs to be reconstituted to 50 μg/mL in sterile 4 mM HCl containing 0.1% BSA, or 4 mM HCl. This protein is hydrophobic by nature, so it requires an acidic buffer for reconstitution to go completely into solution. Stability testing has been evaluated on the protein with these reconstitution conditions; we can guarantee performance under these reconstitution conditions. When the protein is diluted with the cell culture media or buffers to the working concentration, the concentration of the acid should be buffered or negligible.
Recombinant Mouse TGF beta 1 Protein needs to be reconstituted to 50 μg/mL in sterile 4 mM HCl containing 0.1% BSA, or 4 mM HCl. This protein is hydrophobic by nature, so it requires an acidic buffer for reconstitution to go completely into solution. Stability testing has been evaluated on the protein with these reconstitution conditions; we can guarantee performance under these reconstitution conditions. When the protein is diluted with the cell culture media or buffers to the working concentration, the concentration of the acid should be buffered or negligible.
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Is Recombinant Mouse TGF-beta 1 Protein (Catalog # 7666-MB) the latent or mature form?
Recombinant Mouse TGF-beta 1 Protein (Catalog # 7666-MB) is composed of Ala279-Ser390, accession # P04202, which corresponds to mature mouse TGFb1.
Reviews for Recombinant Mouse TGF-beta 1 Protein
Average Rating: 5 (Based on 12 Reviews)
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Reason for Rating: I used this protein in a competition ELISA to see if the antibodies had similar epitopes.
I coated my plate with 50ng/well of recombinant mouse TGF beta 1 protein (cat# 7666-MB) overnight. I washed and blocked with reagent diluent 2 DY995 for 2hr, washed and added another company's TGFb1 antibody at different concentrations 0.2-100ug/mL in reagent diluent 2 and incubated 1hr. I did not wash my wells but add the two antibodies MAB240-biotinylated it in-house and BAF at a final concentration of 2ug/mL and incubated 1hr diluted in reagent diluent 2. I washed and added streptavidin-HRP DY998 (1:200) and incubated 30 mins, washed and developed with the substrate pack DY999. I found MAB240 competed for binding to the mouse TGF beta 1 protein when the competitor's antibody was present but the chicken polyclonal was not inhibited.