Recombinant Mouse TGF-beta 1 Protein

Carrier Free

Catalog # Availability Size / Price Qty
7666-MB-005/CF

With Carrier

Catalog # Availability Size / Price Qty
7666-MB-005
Graph showing dose-dependent bioactivity of mouse TGF-beta 1 protein
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Product Details
Citations (305)
FAQs
Reviews (14)

Recombinant Mouse TGF-beta 1 Protein Summary

Product Specifications

Purity
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Level
<0.01 EU per 1 μg of the protein by the LAL method.
Activity
Measured by its ability to inhibit the IL-4-dependent proliferation of HT‑2 mouse T cells. Tsang, M. et al. (1995) Cytokine 7:389. The ED50 for this effect is 0.04-0.2 ng/mL.
Source
Chinese Hamster Ovary cell line, CHO-derived mouse TGF-beta 1 protein
Ala279-Ser390
Accession #
N-terminal Sequence
Analysis
Ala279
Structure / Form
Disulfide-linked homodimer
Predicted Molecular Mass
12.8 kDa (monomer)
SDS-PAGE
10.5 kDa, reducing conditions

Product Datasheets

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7666-MB (with carrier)

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7666-MB/CF (carrier free)

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

7666-MB

Formulation Lyophilized from a 0.2 μm filtered solution in HCl with BSA as a carrier protein.
Reconstitution Reconstitute at 50 μg/mL in 4 mM HCl containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

7666-MB/CF

Formulation Lyophilized from a 0.2 μm filtered solution in HCl.
Reconstitution Reconstitute at 50 μg/mL in 4 mM HCl.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Scientific Data

Bioactivity Graph showing dose-dependent bioactivity of mouse TGF-beta 1 protein View Larger

Recombinant mouse TGF-beta 1 (7666-MB) inhibits IL-4-dependent proliferation in the HT-2 mouse T cell line. The ED50 for this effect is 0.04-0.2 ng/mL.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: TGF-beta 1

TGF-beta 1 (transforming growth factor beta 1) is one of three closely related mammalian members of the large TGF‑ beta superfamily that share a characteristic cystine knot structure (1‑7). TGF‑ beta 1, -2 and -3 are highly pleiotropic cytokines that are proposed to act as cellular switches that regulate processes such as immune function, proliferation and epithelial‑mesenchymal transition (1‑4). Each TGF‑ beta isoform has some non‑redundant functions; for TGF‑ beta 1, mice with targeted deletion show defects in hematopoiesis and endothelial differentiation, and die of overwhelming inflammation (2). Human or mouse TGF‑ beta 1 cDNA encodes a 390 amino acid (aa) precursor that contains a 29 aa signal peptide and a 361 aa proprotein (8). A furin‑like convertase processes the proprotein to generate an N‑terminal 249 aa latency‑associated peptide (LAP) and a C‑terminal 112 aa mature TGF‑ beta 1 (8, 9). Disulfide‑linked homodimers of LAP and TGF‑ beta 1 remain non‑covalently associated after secretion, forming the small latent TGF‑ beta 1 complex (8‑10). Covalent linkage of LAP to one of three latent TGF‑ beta binding proteins (LTBPs) creates a large latent complex that may interact with the extracellular matrix (9, 10). TGF‑ beta is activated from latency by pathways that include actions of the protease plasmin, matrix metalloproteases, thrombospondin 1 and a subset of integrins (10). Mature mouse TGF‑ beta 1 shares 99‑100% aa sequence identity with human, rat, equine, porcine, canine and bovine TGF‑ beta 1. It demonstrates cross‑species activity (1). TGF‑ beta 1 signaling begins with high‑affinity binding to a type II ser/thr kinase receptor termed TGF‑ beta  RII. This receptor then phosphorylates and activates a second ser/thr kinase receptor, TGF‑ beta  RI (also called activin receptor‑like kinase (ALK) ‑5), or alternatively, ALK‑1. This complex phosphorylates and activates Smad proteins that regulate transcription (3, 11, 12). Contributions of the accessory receptors betaglycan (also known as TGF‑ beta  RIII) and endoglin, or use of Smad‑independent signaling pathways, allow for disparate actions observed in response to TGF‑ beta in different contexts (11).

References
  1. Derynck, R. and K. Miyazono (2008) Cold Spring Harbor Laboratory Press, 29.
  2. Dunker, N. and K. Krieglstein (2000) Eur. J. Biochem. 267:6982.
  3. Wahl, S.M. (2006) Immunol. Rev. 213:213.
  4. Chang, H. et al. (2002) Endocr. Rev. 23:787.
  5. Lin, J.S. et al. (2006) Reproduction 132:179.
  6. Hinck, A.P. et al. (1996) Biochemistry 35:8517.
  7. Mittl, P.R.E. et al. (1996) Protein Sci. 5:1261.
  8. Derynck, R. et al. (1985) Nature 316:701.
  9. Miyazono, K. et al. (1988) J. Biol. Chem. 263:6407.
  10. Oklu, R. and R. Hesketh (2000) Biochem. J. 352:601.
  11. de Caestecker, M. et al. (2004) Cytokine Growth Factor Rev. 15:1.
  12. Zuniga, J.E. et al. (2005) J. Mol. Biol. 354:1052.
Long Name
Transforming Growth Factor beta 1
Entrez Gene IDs
7040 (Human); 21803 (Mouse); 59086 (Rat); 397078 (Porcine); 100033900 (Equine)
Alternate Names
CEDLAP; DPD1; latency-associated peptide; TGF beta; TGF beta1; TGFB; TGFB1; TGF-beta 1 protein; TGFbeta 1; TGF-beta 1; TGFbeta; TGF-beta-1; transforming growth factor beta-1; transforming growth factor, beta 1

Citations for Recombinant Mouse TGF-beta 1 Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

305 Citations: Showing 1 - 10
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  1. Mast4 determines the cell fate of MSCs for bone and cartilage development
    Authors: P Kim, J Park, DJ Lee, S Mizuno, M Shinohara, CP Hong, Y Jeong, R Yun, H Park, S Park, KM Yang, MJ Lee, SP Jang, HY Kim, SJ Lee, SU Song, KS Park, M Tanaka, H Ohshima, JW Cho, F Sugiyama, S Takahashi, HS Jung, SJ Kim
    Nature Communications, 2022;13(1):3960.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  2. A neutrophil/TGF-beta axis limits the pathogenicity of allergen-specific CD4+ T cells
    Authors: GS Whitehead, SY Thomas, K Nakano, DJ Royer, CG Burke, H Nakano, DN Cook
    JCI Insight, 2022;7(4):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  3. Aryl hydrocarbon receptor signals in epithelial cells govern the recruitment and location of Helios+ Tregs in the gut
    Authors: Y Yoshimatsu, T Sujino, K Miyamoto, Y Harada, S Tanemoto, K Ono, S Umeda, K Yoshida, T Teratani, T Suzuki, Y Mikami, N Nakamoto, N Sasaki, K Takabayash, N Hosoe, H Ogata, K Sawada, T Imamura, A Yoshimura, T Kanai
    Cell Reports, 2022;39(6):110773.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  4. Acetylation licenses Th1 cell polarization to constrain Listeria monocytogenes infection
    Authors: YS Zhang, DE Xin, Z Wang, W Peng, Y Zeng, J Liang, M Xu, N Chen, J Zhang, J Yue, M Cao, C Zhang, Y Wang, Z Chang, XM Lu, L Chang, YE Chinn
    Cell Death and Differentiation, 2022;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  5. Dynamic Visualization of TGF-beta/SMAD3 Transcriptional Responses in Single Living Cells
    Authors: DL Marvin, L You, L Bornes, M van Dinthe, N Peters, H Dang, SK Hakuno, M Hornsveld, O Kranenburg, J van Rheene, JHT Rohling, MP Chien, P Ten Dijke, L Ritsma
    Cancers, 2022;14(10):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  6. Oxy210, a Semi-Synthetic Oxysterol, Exerts Anti-Inflammatory Effects in Macrophages via Inhibition of Toll-like Receptor (TLR) 4 and TLR2 Signaling and Modulation of Macrophage Polarization
    Authors: F Wang, F Stappenbec, LY Tang, YE Zhang, ST Hui, AJ Lusis, F Parhami
    International Journal of Molecular Sciences, 2022;23(10):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  7. Repeated Social Defeat Enhances CaCl2-Induced Abdominal Aortic Aneurysm Expansion by Inhibiting the Early Fibrotic Response via the MAPK-MKP-1 Pathway
    Authors: H Kubota, H Yamada, T Sugimoto, N Wada, S Motoyama, M Saburi, D Miyawaki, N Wakana, D Kami, T Ogata, M Ibi, S Matoba
    Cells, 2022;11(4):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  8. Notch-mediated Ephrin signaling disrupts islet architecture and beta cell function
    Authors: A Bartolomé, N Suda, J Yu, C Zhu, J Son, H Ding, A Califano, D Accili, UB Pajvani
    JCI Insight, 2022;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  9. MGP Regulates Perivascular Adipose-Derived Stem Cells Differentiation Toward Smooth Muscle Cells Via BMP2/SMAD Pathway Enhancing Neointimal Formation
    Authors: H Ni, C Liu, Y Chen, Y Lu, Y Ji, M Xiang, Y Xie
    Cell Transplantation, 2022;31(0):9636897221075.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  10. Antioxidative enzyme NAD(P)H quinone oxidoreductase 1 (NQO1) modulates the differentiation of Th17 cells by regulating ROS levels
    Authors: K Nishida-Ta, A Kimura, T Tsubata, S Takahashi, H Suzuki
    PLoS ONE, 2022;17(7):e0272090.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  11. Macrophage elastase (MMP12) critically contributes to the development of subretinal fibrosis
    Authors: C Yi, J Liu, W Deng, C Luo, J Qi, M Chen, H Xu
    Journal of Neuroinflammation, 2022;19(1):78.
    Species: Mouse
    Sample Types: Whole Cell
    Applications: Bioassay
  12. C-MYC induces idiopathic pulmonary fibrosis via modulation of miR-9-5p-mediated TBPL1
    Authors: H Qin, Y Tang, Y Mao, X Zhou, T Xu, W Liu, X Su
    Cellular Signalling, 2022;0(0):110274.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  13. Protection of nascent DNA at stalled replication forks is mediated by phosphorylation of RIF1 intrinsically disordered region
    Authors: S Balasubram, M Andreani, JG Andrade, T Saha, D Sundaravin, J Garzón, W Zhang, O Popp, SI Hiraga, A Rahjouei, DB Rosen, P Mertins, BT Chait, AD Donaldson, M Di Virgili
    Elife, 2022;11(0):.
    Species: Mouse
    Sample Types: Whole Cell
    Applications: Stimulation
  14. EBV+ tumors exploit tumor cell-intrinsic and -extrinsic mechanisms to produce regulatory T cell-recruiting chemokines CCL17 and CCL22
    Authors: A Jorapur, LA Marshall, S Jacobson, M Xu, S Marubayash, M Zibinsky, DX Hu, O Robles, JJ Jackson, V Baloche, P Busson, D Wustrow, DG Brockstedt, O Talay, PD Kassner, G Cutler
    PloS Pathogens, 2022;18(1):e1010200.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  15. PGC-1alpha inhibits the NLRP3 inflammasome via preserving mitochondrial viability to protect kidney fibrosis
    Authors: BY Nam, JH Jhee, J Park, S Kim, G Kim, JT Park, TH Yoo, SW Kang, JW Yu, SH Han
    Cell Death & Disease, 2022;13(1):31.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  16. The histone methyltransferase DOT1L is a new epigenetic regulator of pulmonary fibrosis
    Authors: D Yang, P Xu, H Su, W Zhong, J Xu, Z Su, X Liu
    Cell Death & Disease, 2022;13(1):60.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  17. Identification of distinct non-myogenic skeletal-muscle-resident mesenchymal cell populations
    Authors: AP Leinroth, AJ Mirando, D Rouse, Y Kobayahsi, PR Tata, HE Rueckert, Y Liao, JT Long, JV Chakkalaka, MJ Hilton
    Cell Reports, 2022;39(6):110785.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  18. Mulberrin confers protection against hepatic fibrosis by Trim31/Nrf2 signaling
    Authors: C Ge, J Tan, D Lou, L Zhu, Z Zhong, X Dai, Y Sun, Q Kuang, J Zhao, L Wang, J Liu, B Wang, M Xu
    Redox Biology, 2022;51(0):102274.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  19. MAP4K3/GLK inhibits Treg differentiation by direct phosphorylating IKKbeta and inducing IKKbeta-mediated FoxO1 nuclear export and Foxp3 downregulation
    Authors: JN Chi, JY Yang, CH Hsueh, CY Tsai, HC Chuang, TH Tan
    Theranostics, 2022;12(13):5744-5760.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  20. Traject3d allows label-free identification of distinct co-occurring phenotypes within 3D culture by live imaging
    Authors: EC Freckmann, E Sandilands, E Cumming, M Neilson, A Román-Fern, K Nikolatou, M Nacke, TRM Lannagan, A Hedley, D Strachan, M Salji, JP Morton, L McGarry, HY Leung, OJ Sansom, CJ Miller, DM Bryant
    Nature Communications, 2022;13(1):5317.
    Species: Mouse
    Sample Types: Organoid
    Applications: Bioassay
  21. TGFbeta reprograms TNF stimulation of macrophages towards a non-canonical pathway driving inflammatory osteoclastogenesis
    Authors: Y Xia, K Inoue, Y Du, SJ Baker, E Premkumar, MB Greenblatt, B Zhao
    Nature Communications, 2022;13(1):3920.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  22. EPDR1 is a Non-canonical Effector of Insulin-mediated Angiogenesis Regulated by an Endothelial-specific TGF-beta Receptor Complex
    Authors: T Ahmed, PC Flores, CC Pan, HR Ortiz, YS Lee, PR Langlais, K Mythreye, NY Lee
    The Journal of Biological Chemistry, 2022;0(0):102297.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  23. hUC-EVs-ATO reduce the severity of acute GVHD by resetting inflammatory macrophages toward the M2 phenotype
    Authors: Y Su, X Sun, X Liu, Q Qu, L Yang, Q Chen, F Liu, Y Li, Q Wang, B Huang, XJ Huang, XH Zhang
    Journal of hematology & oncology, 2022;15(1):99.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  24. Simple gene signature to assess murine fibroblast polarization
    Authors: E Ledoult, M Jendoubi, A Collet, T Guerrier, A Largy, S Speca, S Vivier, F Bray, M Figeac, E Hachulla, M Labalette, F Leprêtre, S Sebda, S Sanges, C Rolando, V Sobanski, S Dubucquoi, D Launay
    Scientific Reports, 2022;12(1):11748.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  25. Hepatoprotective Effects of a Natural Flavanol 3,3'-Diindolylmethane against CCl4-Induced Chronic Liver Injury in Mice and TGFbeta1-Induced EMT in Mouse Hepatocytes via Activation of Nrf2 Cascade
    Authors: S Munakarmi, Y Gurau, J Shrestha, P Risal, HS Park, HB Shin, YJ Jeong
    International Journal of Molecular Sciences, 2022;23(19):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  26. Stimulated phosphorylation of ERK in mouse kidney mesangial cells is dependent upon expression of Cav3.1
    Authors: SPS Pandi, MJ Shattock, BM Hendry, CC Sharpe
    Oncogene, 2022;23(1):211.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  27. Functional genomics uncovers the transcription factor BNC2 as required for myofibroblastic activation in fibrosis
    Authors: M Bobowski-G, C Boulet, FP Zummo, J Dubois-Che, C Gheeraert, M Bou Saleh, JM Strub, A Farce, M Ploton, L Guille, J Vandel, A Bongiovann, N Very, E Woitrain, A Deprince, F Lalloyer, E Bauge, L Ferri, LC Ntandja-Wa, AK Cotte, C Grangette, E Vallez, S Cianférani, V Raverdy, R Caiazzo, V Gnemmi, E Leteurtre, B Pourcet, R Paumelle, K Ravnskjaer, G Lassailly, JT Haas, P Mathurin, F Pattou, L Dubuquoy, B Staels, P Lefebvre, J Eeckhoute
    Nature Communications, 2022;13(1):5324.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  28. Salvianolic acid B dry powder inhaler for the treatment of idiopathic pulmonary fibrosis
    Authors: P Lu, J Li, C Liu, J Yang, H Peng, Z Xue, Z Liu
    Asian journal of pharmaceutical sciences, 2022;17(3):447-461.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  29. Interferon-beta promotes the survival and function of induced regulatory T cells
    Authors: N Nishiyama, C Nakahashi-, A Shibuya
    Cytokine, 2022;158(0):156009.
    Species: Transgenic Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  30. Cryptotanshinone ameliorates dextran sulfate sodium-induced murine acute and chronic ulcerative colitis via suppressing STAT3 activation and Th17 cell differentiation
    Authors: LM Fan, YQ Zhang, YP Chen, LL Chen, WH Xu, LH Nan, W Xu, B Lu, Y Wang, KD Chu, JP Zhang
    Oncogene, 2022;108(0):108894.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  31. Notch2-dependent GATA3+ Treg cells alleviate allergic rhinitis by suppressing the Th2 cell response
    Authors: WE Jiao, S Xu, YL Qiao, YG Kong, L Sun, YQ Deng, R Yang, ZZ Tao, QQ Hua, SM Chen
    International immunopharmacology, 2022;112(0):109261.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  32. Genetic Characterization of Rat Hepatic Stellate Cell Line HSC-T6 for In Vitro Cell Line Authentication
    Authors: I Nanda, C Steinlein, T Haaf, EM Buhl, DG Grimm, SL Friedman, SK Meurer, SK Schröder, R Weiskirche
    Cells, 2022;11(11):.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  33. Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia
    Authors: EG Vasquez, N Nasreddin, GN Valbuena, EJ Mulholland, HL Belnoue-Da, HR Eggington, RO Schenck, VM Wouters, P Wirapati, K Gilroy, TRM Lannagan, DJ Flanagan, AK Najumudeen, S Omwenga, AMB McCorry, A Easton, VH Koelzer, JE East, D Morton, L Trusolino, T Maughan, AD Campbell, MB Loughrey, PD Dunne, P Tsantoulis, DJ Huels, S Tejpar, OJ Sansom, SJ Leedham
    Cell Stem Cell, 2022;29(8):1213-1228.e8.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  34. AFF3, a susceptibility factor for autoimmune diseases, is a molecular facilitator of immunoglobulin class switch recombination
    Authors: SI Tsukumo, PG Subramani, N Seija, M Tabata, Y Maekawa, Y Mori, C Ishifune, Y Itoh, M Ota, K Fujio, JM Di Noia, K Yasutomo
    Science Advances, 2022;8(34):eabq0008.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  35. Mouse Model of Loeys-Dietz Syndrome Shows Elevated Susceptibility to Periodontitis via Alterations in Transforming Growth Factor-Beta Signaling
    Authors: S Yamada, K Tsushima, M Kinoshita, H Sakashita, T Kajikawa, C Fujihara, H Yuan, S Suzuki, T Morisaki, S Murakami
    Frontiers in Physiology, 2021;12(0):715687.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  36. Targeting microRNA-mediated gene repression limits adipogenic conversion of skeletal muscle mesenchymal stromal cells
    Authors: MN Wosczyna, EE Perez Carb, MW Wagner, S Paredes, CT Konishi, L Liu, TT Wang, RA Walsh, Q Gan, CS Morrissey, TA Rando
    Cell Stem Cell, 2021;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  37. TGF&beta signaling curbs cell fusion and muscle regeneration
    Authors: F Girardi, A Taleb, M Ebrahimi, A Datye, DG Gamage, C Peccate, L Giordani, DP Millay, PM Gilbert, B Cadot, F Le Grand
    Nature Communications, 2021;12(1):750.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Bioassay
  38. In vivo silencing of amphiregulin by a novel effective Self-Assembled-Micelle inhibitory RNA ameliorates renal fibrosis via inhibition of EGFR signals
    Authors: SS Son, S Hwang, JH Park, Y Ko, SI Yun, JH Lee, B Son, TR Kim, HO Park, EY Lee
    Scientific Reports, 2021;11(1):2191.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  39. Interferon-beta Intensifies Interleukin-23-Driven Pathogenicity of T Helper Cells in Neuroinflammatory Disease
    Authors: A Agasing, JL Quinn, G Kumar, RC Axtell
    Cells, 2021;10(8):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  40. The YAP/HIF-1&alpha/miR-182/EGR2 axis is implicated in asthma severity through the control of Th17 cell differentiation
    Authors: J Zhou, N Zhang, W Zhang, C Lu, F Xu
    Cell & bioscience, 2021;11(1):84.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  41. The Downregulation of ADAM17 Exerts Protective Effects against Cardiac Fibrosis by Regulating Endoplasmic Reticulum Stress and Mitophagy
    Authors: C Guan, HF Zhang, YJ Wang, ZT Chen, BQ Deng, Q Qiu, SX Chen, MX Wu, YX Chen, JF Wang
    Oxidative Medicine and Cellular Longevity, 2021;2021(0):5572088.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  42. Essential role of a ThPOK autoregulatory loop in the maintenance of mature CD4+ T cell identity and function
    Authors: J Basu, BS Reis, S Peri, J Zha, X Hua, L Ge, K Ferchen, E Nicolas, P Czyzewicz, KQ Cai, Y Tan, JI Fuxman Bas, AJM Walhout, HL Grimes, SI Grivenniko, D Mucida, DJ Kappes
    Nature Immunology, 2021;22(8):969-982.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  43. Astrocyte-Derived TGF&beta1 Facilitates Blood-Brain Barrier Function via Non-Canonical Hedgehog Signaling in Brain Microvascular Endothelial Cells
    Authors: J Fu, L Li, D Huo, S Zhi, R Yang, B Yang, B Xu, T Zhang, M Dai, C Tan, H Chen, X Wang
    Brain sciences, 2021;11(1):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Bioassay
  44. m6A demethylase ALKBH5 controls CD4+ T cell pathogenicity and promotes autoimmunity
    Authors: J Zhou, X Zhang, J Hu, R Qu, Z Yu, H Xu, H Chen, L Yan, C Ding, Q Zou, Y Ye, Z Wang, RA Flavell, HB Li
    Science Advances, 2021;7(25):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  45. Similarities and differences between IL11 and IL11RA1 knockout mice for lung fibro-inflammation, fertility and craniosynostosis
    Authors: B Ng, AA Widjaja, S Viswanatha, J Dong, SP Chothani, S Lim, SG Shekeran, J Tan, NE McGregor, EC Walker, NA Sims, S Schafer, SA Cook
    Scientific Reports, 2021;11(1):14088.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  46. Anlotinib Inhibits PFKFB3-Driven Glycolysis in Myofibroblasts to Reverse Pulmonary Fibrosis
    Authors: W Chen, J Zhang, W Zhong, Y Liu, Y Lu, Z Zeng, H Huang, X Wan, X Meng, F Zou, S Cai, H Dong
    Frontiers in Pharmacology, 2021;12(0):744826.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  47. Glucose limitation activates AMPK coupled SENP1-Sirt3 signalling in mitochondria for T cell memory development
    Authors: J He, X Shangguan, W Zhou, Y Cao, Q Zheng, J Tu, G Hu, Z Liang, C Jiang, L Deng, S Wang, W Yang, Y Zuo, J Ma, R Cai, Y Chen, Q Fan, B Dong, W Xue, H Tan, Y Qi, J Gu, B Su, Y Eugene Chi, G Chen, Q Wang, T Wang, J Cheng
    Nature Communications, 2021;12(1):4371.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  48. Reduced TGF-beta Expression and CD206-Positive Resident Macrophages in the Intervertebral Discs of Aged Mice
    Authors: Y Yokozeki, A Kawakubo, M Miyagi, A Kuroda, H Sekiguchi, G Inoue, M Takaso, K Uchida
    BioMed Research International, 2021;2021(0):7988320.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  49. miR-200c-3p Regulates Epitelial-to-Mesenchymal Transition in Epicardial Mesothelial Cells by Targeting Epicardial Follistatin-Related Protein 1
    Authors: E Pontemezzo, E Foglio, E Vernucci, A Magenta, M D'Agostino, S Sileno, E Astanina, F Bussolino, L Pellegrini, A Germani, MA Russo, F Limana
    International Journal of Molecular Sciences, 2021;22(9):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  50. Meningitic Escherichia coli alpha-hemolysin aggravates blood-brain barrier disruption via targeting TGFbeta1-triggered hedgehog signaling
    Authors: J Fu, L Li, D Huo, R Yang, B Yang, B Xu, X Yang, M Dai, C Tan, H Chen, X Wang
    Molecular Brain, 2021;14(1):116.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  51. Bruton's tyrosine kinase regulates gut immune homeostasis through attenuating Th1 response
    Authors: D Guan, Z Wang, J Huo, S Xu, KP Lam
    Cell Death & Disease, 2021;12(5):431.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  52. The ubiquitin ligase NEDD4-2/NEDD4L regulates both sodium homeostasis and fibrotic signaling to prevent end-stage renal disease
    Authors: JA Manning, SS Shah, A Nikolic, TL Henshall, Y Khew-Gooda, S Kumar
    Cell Death & Disease, 2021;12(4):398.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  53. Identification of Small Molecule Inhibitors of a Mir155 Transcriptional Reporter in Th17 Cells
    Authors: A Singh, M Dashynam, B Chim, TM Escobar, X Liu, X Hu, S Patnaik, X Xu, N Southall, J Marugan, A Jadhav, V Lazarevic, SA Muljo, M Ferrer
    Scientific Reports, 2021;11(1):11498.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  54. Adenosine/TGF&beta axis in regulation of mammary fibroblast functions
    Authors: G Vasiukov, A Menshikh, P Owens, T Novitskaya, P Hurley, T Blackwell, I Feoktistov, SV Novitskiy
    PLoS ONE, 2021;16(6):e0252424.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  55. Differential Cytokine-Induced Responses of Polarized Microglia
    Authors: P Chauhan, WS Sheng, S Hu, S Prasad, JR Lokensgard
    Brain sciences, 2021;11(11):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  56. Aberrant TGF-&beta1 signaling activation by MAF underlies pathological lens growth in high myopia
    Authors: X Zhu, Y Du, D Li, J Xu, Q Wu, W He, K Zhang, J Zhu, L Guo, M Qi, A Liu, J Qi, G Wang, J Meng, Z Yang, K Zhang, Y Lu
    Nature Communications, 2021;12(1):2102.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  57. The ATP synthase inhibition induces an AMPK-dependent glycolytic switch of mesenchymal stem cells that enhances their immunotherapeutic potential
    Authors: R Contreras-, R Elizondo-V, N Luque-Camp, MJ Torres, C Pradenas, G Tejedor, MJ Paredes-Ma, AM Vega-Lette, M Campos-Mor, Y Rigual-Gon, K Oyarce, M Salgado, C Jorgensen, M Khoury, MLÁ Garcia-Rob, C Altamirano, F Djouad, P Luz-Crawfo
    Theranostics, 2021;11(1):445-460.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  58. TGF-beta regulates nerve growth factor expression in a mouse intervertebral disc injury model
    Authors: Y Yokozeki, K Uchida, A Kawakubo, M Nakawaki, T Okubo, M Miyagi, G Inoue, M Itakura, H Sekiguchi, M Takaso
    Bmc Musculoskeletal Disorders, 2021;22(1):634.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  59. Tetrandrine Modulates Rheb-mTOR Signaling-Mediated Selective Autophagy and Protects Pulmonary Fibrosis
    Authors: Y Liu, W Zhong, J Zhang, W Chen, Y Lu, Y Qiao, Z Zeng, H Huang, S Cai, H Dong
    Frontiers in Pharmacology, 2021;12(0):739220.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  60. Oligodendrocyte precursor cell specification is regulated by bidirectional neural progenitor-endothelial cell crosstalk
    Authors: I Paredes, JR Vieira, B Shah, CF Ramunno, J Dyckow, H Adler, M Richter, G Schermann, E Giannakour, L Schirmer, HG Augustin, C Ruiz de Al
    Nature Neuroscience, 2021;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  61. Asthma reduces glioma formation by T cell decorin-mediated inhibition of microglia
    Authors: J Chatterjee, S Sanapala, O Cobb, A Bewley, AK Goldstein, E Cordell, X Ge, JR Garbow, MJ Holtzman, DH Gutmann
    Nature Communications, 2021;12(1):7122.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  62. Effect of TGF-beta1 on eosinophils to induce cysteinyl leukotriene E4 production in aspirin-exacerbated respiratory disease
    Authors: Y Choi, S Sim, DH Lee, HR Lee, GY Ban, YS Shin, YK Kim, HS Park
    PLoS ONE, 2021;16(8):e0256237.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Bioassay
  63. HIF-1&alpha is necessary for activation and tumour-promotion effect of cancer-associated fibroblasts in lung cancer
    Authors: Y Zhang, Y Bian, Y Wang, Y Wang, X Duan, Y Han, L Zhang, F Wang, Z Gu, Z Qin
    Journal of Cellular and Molecular Medicine, 2021;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  64. Death-Associated Protein 6 (Daxx) Alleviates Liver Fibrosis by Modulating Smad2 Acetylation
    Authors: SM Kim, WH Hur, BY Kang, SW Lee, PR Roh, DJ Park, PS Sung, SK Yoon
    Cells, 2021;10(7):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  65. Harnessing hyaluronic acid-based nanoparticles for combination therapy: A novel approach for suppressing systemic inflammation and to promote antitumor macrophage polarization
    Authors: VK Rangasami, S Samanta, VS Parihar, K Asawa, K Zhu, OP Varghese, Y Teramura, B Nilsson, J Hilborn, RA Harris, OP Oommen
    Carbohydrate polymers, 2021;254(0):117291.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  66. Deleterious Role of Th9 Cells in Pulmonary Fibrosis
    Authors: KM Deng, XS Yang, Q Luo, YX She, QY Yu, XX Tang
    Cells, 2021;10(11):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  67. Transforming growth factor-beta1 decreases erythropoietin production through repressing hypoxia-inducible factor 2alpha in erythropoietin-producing cells
    Authors: HM Shih, SY Pan, CJ Wu, YH Chou, CY Chen, FC Chang, YT Chen, WC Chiang, HC Tsai, YM Chen, SL Lin
    Journal of Biomedical Science, 2021;28(1):73.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  68. The effect of macrophage polarization on the expression of the oxytocin signalling system in enteric neurons
    Authors: Y Shi, S Li, H Zhang, J Zhu, T Che, B Yan, J Li, C Liu
    Journal of Neuroinflammation, 2021;18(1):261.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  69. FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation
    Authors: Y Feng, C Li, JA Stewart, P Barbulescu, NS Desivo, A Álvarez-Qu, RC Pezo, MLW Perera, K Chan, AHY Tong, R Mohamad-Ra, M Berru, D Nakib, G Li, GA Kardar, JR Carlyle, J Moffat, D Durocher, JM Di Noia, AS Bhagwat, A Martin
    Nature, 2021;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  70. Fam72a enforces error-prone DNA repair during antibody diversification
    Authors: M Rogier, J Moritz, I Robert, C Lescale, V Heyer, A Abello, O Martin, K Capitani, M Thomas, AS Thomas-Cla, B Laffleur, F Jouan, E Pinaud, K Tarte, M Cogné, SG Conticello, E Soutoglou, L Deriano, B Reina-San-
    Nature, 2021;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  71. N-Acetyldopamine derivatives from Periostracum Cicadae and their regulatory activities on Th1 and Th17 cell differentiation
    Authors: P Thapa, Y Gu, YS Kil, SC Baek, KH Kim, AR Han, EK Seo, H Choi, JH Chang, JW Nam
    Bioorg. Chem., 2020;102(0):104095.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  72. Different Regulation of Glut1 Expression and Glucose Uptake during the Induction and Chronic Stages of TGF&beta1-Induced EMT in Breast Cancer Cells
    Authors: A Nilchian, N Giotopoulo, W Sun, J Fuxe
    Biomolecules, 2020;10(12):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  73. Differential regulation of Lipocalin 2 (LCN2) in doxorubicin-resistant 4T1 triple negative breast cancer cells
    Authors: SK Meurer, O Tezcan, T Lammers, R Weiskirche
    Cell. Signal., 2020;74(0):109731.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  74. Macrophages directly contribute collagen to scar formation during zebrafish heart regeneration and mouse heart repair
    Authors: FC Simões, TJ Cahill, A Kenyon, D Gavriouchk, JM Vieira, X Sun, D Pezzolla, C Ravaud, E Masmanian, M Weinberger, S Mayes, ME Lemieux, DN Barnette, M Gunadasa-R, RM Williams, DR Greaves, LA Trinh, SE Fraser, SL Dallas, RP Choudhury, T Sauka-Spen, PR Riley
    Nat Commun, 2020;11(1):600.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  75. Functional Radiogenetic Profiling Implicates ERCC6L2 in Non-homologous End Joining
    Authors: P Francica, M Mutlu, VA Blomen, C Oliveira, Z Nowicka, A Trenner, NM Gerhards, P Bouwman, E Stickel, ML Hekkelman, L Lingg, I Klebic, M van de Ven, R de Korte-G, D Howald, J Jonkers, AA Sartori, W Fendler, JR Chapman, T Brummelkam, S Rottenberg
    Cell Rep, 2020;32(8):108068.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  76. Identification of the growth factor binding sequence in the extracellular matrix protein MAGP-1
    Authors: TJ Broekelman, NK Bodmer, RP Mecham
    J. Biol. Chem., 2020;0(0):.
    Species: N/A
    Sample Types: Protein
    Applications: Surface Plasmon Resonance
  77. Neurokinin-1 Receptor Signaling Is Required for Efficient Ca2+ Flux in T-Cell-Receptor-Activated T Cells
    Authors: AE Morelli, TL Sumpter, DM Rojas-Cana, M Bandyopadh, Z Chen, O Tkacheva, WJ Shufesky, CT Wallace, SC Watkins, A Berger, CJ Paige, LD Falo, AT Larregina
    Cell Rep, 2020;30(10):3448-3465.e8.
    Species: Mouse
    Sample Types: Dendritic Cells
    Applications: Bioassay
  78. NOX4 Inhibition Potentiates Immunotherapy by Overcoming Cancer-Associated Fibroblast-Mediated CD8 T-cell Exclusion from Tumors
    Authors: K Ford, CJ Hanley, M Mellone, C Szyndralew, F Heitz, P Wiesel, O Wood, M Machado, MA Lopez, AP Ganesan, C Wang, A Chakravart, TR Fenton, EV King, P Vijayanand, CH Ottensmeie, A Al-Shamkha, N Savelyeva, GJ Thomas
    Cancer Res., 2020;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  79. Sirt1 antisense long non-coding RNA attenuates pulmonary fibrosis through sirt1-mediated epithelial-mesenchymal transition
    Authors: W Qian, X Cai, Q Qian
    Aging (Albany NY), 2020;12(5):4322-4336.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  80. TGF&beta suppresses CD8+ T cell expression of CXCR3 and tumor trafficking
    Authors: AJ Gunderson, T Yamazaki, K McCarty, N Fox, M Phillips, A Alice, T Blair, M Whiteford, D O'Brien, R Ahmad, MX Kiely, A Hayman, T Crocenzi, MJ Gough, MR Crittenden, KH Young
    Nat Commun, 2020;11(1):1749.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  81. PPAR&beta/&delta-dependent MSC metabolism determines their immunoregulatory properties
    Authors: RA Contreras-, R Elizondo-V, MJ Torres, AM Vega-Lette, N Luque-Camp, MJ Paredes-Ma, C Pradenas, G Tejedor, K Oyarce, M Salgado, C Jorgensen, M Khoury, G Kronke, MA Garcia-Rob, C Altamirano, P Luz-Crawfo, F Djouad
    Sci Rep, 2020;10(1):11423.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  82. Effects of senataxin and RNA exosome on B-cell chromosomal integrity
    Authors: D Kazadi, J Lim, G Rothschild, V Grinstein, B Laffleur, O Becherel, MJ Lavin, U Basu
    Heliyon, 2020;6(3):e03442.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  83. Osteoprotegerin is More than a Possible Serum Marker in Liver Fibrosis: A Study into its Function in Human and Murine Liver
    Authors: A Adhyatmika, L Beljaars, KSS Putri, H Habibie, CE Boorsma, C Reker-Smit, T Luangmonko, B Guney, A Haak, KA Mangnus, E Post, K Poelstra, K Ravnskjaer, P Olinga, BN Melgert
    Pharmaceutics, 2020;12(5):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Tissue Culture
  84. Conditional deletion of Nedd4-2 in lung epithelial cells causes progressive pulmonary fibrosis in adult mice
    Authors: J Duerr, DHW Leitz, M Szczygiel, D Dvornikov, SG Fraumann, C Kreutz, PK Zadora, A Seyhan Agi, P Konietzke, TA Engelmann, J Hegermann, S Mulugeta, H Kawabe, L Knudsen, M Ochs, D Rotin, T Muley, M Kreuter, FJF Herth, MO Wielpütz, MF Beers, U Klingmülle, MA Mall
    Nat Commun, 2020;11(1):2012.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  85. TLR9 Sensing of Self-DNA Controls Cell-Mediated Immunity to Listeria Infection via Rapid Conversion of Conventional CD4+ T Cells to Treg
    Authors: JS Dolina, J Lee, RQ Griswold, L Labarta-Ba, S Kannan, JA Greenbaum, N Bahia El I, MJ Pont, M Croft, SP Schoenberg
    Cell Rep, 2020;31(1):107249.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  86. Canonical and noncanonical TGF-&beta signaling regulate fibrous tissue differentiation in the axial skeleton
    Authors: SW Clayton, GI Ban, C Liu, R Serra
    Scientific Reports, 2020;10(1):21364.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  87. Myeloid cell-derived TGF-beta signaling regulates ECM deposition in mammary carcinoma via adenosine-dependent mechanisms
    Authors: G Vasiukov, T Novitskaya, A Zijlstra, P Owens, F Ye, Z Zhao, HL Moses, T Blackwell, I Feoktistov, SV Novitskiy
    Cancer Res., 2020;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  88. B cell Sirt1 deacetylates histone and non-histone proteins for epigenetic modulation of AID expression and the antibody response
    Authors: H Gan, T Shen, DP Chupp, JR Taylor, HN Sanchez, X Li, Z Xu, H Zan, P Casali
    Sci Adv, 2020;6(14):eaay2793.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  89. NFAT-Specific Inhibition by dNP2-VIVITAmeliorates Autoimmune Encephalomyelitisby Regulation of Th1 and Th17
    Authors: HG Lee, LK Kim, JM Choi
    Mol Ther Methods Clin Dev, 2020;16(0):32-41.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  90. Oral therapy with colonization factor antigen I prevents development of type 1 diabetes in Non-obese Diabetic mice
    Authors: AS Nelson, M Maddaloni, JR Abbott, C Hoffman, A Akgul, C Ohland, RZ Gharaibeh, C Jobin, TM Brusko, DW Pascual
    Sci Rep, 2020;10(1):6156.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: ELISA Standard
  91. Novel AXL-specific inhibitor ameliorates kidney dysfunction through the inhibition of epithelial-to-mesenchymal transition of renal tubular cells
    Authors: A Kurata, Y Tachibana, T Takahashi, N Horiba
    PLoS ONE, 2020;15(4):e0232055.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Cell Culture
  92. Methylation in pericytes after acute injury promotes chronic kidney disease
    Authors: YH Chou, SY Pan, YH Shao, HM Shih, SY Wei, CF Lai, WC Chiang, C Schrimpf, KC Yang, LC Lai, YM Chen, TS Chu, SL Lin
    J. Clin. Invest., 2020;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  93. LRR domain of NLRX1 protein delivery by dNP2 inhibits T cell functions and alleviates autoimmune encephalomyelitis
    Authors: JH Koo, DH Kim, D Cha, MJ Kang, JM Choi
    Theranostics, 2020;10(7):3138-3150.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  94. Impact of HIV-1 Vpr manipulation of the DNA repair enzyme UNG2 on B lymphocyte class switch recombination
    Authors: P Eldin, S Péron, A Galashevsk, N Denis-Laga, M Cogné, G Slupphaug, L Briant
    J Transl Med, 2020;18(1):310.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  95. IL-6 Deficiency Exacerbates Allergic Asthma and Abrogates the Protective Effect of Allergic Inflammation against Streptococcus pneumoniae Pathogenesis
    Authors: T Schmit, S Ghosh, RK Mathur, T Barnhardt, G Ambigapath, M Wu, C Combs, MN Khan
    J. Immunol., 2020;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  96. Targeting fibroblast CD248 attenuates CCL17-expressing macrophages and tissue fibrosis
    Authors: CH Pai, SR Lin, CH Liu, SY Pan, H Hsu, YT Chen, CT Yen, IS Yu, HL Wu, SL Lin, SW Lin
    Sci Rep, 2020;10(1):16772.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  97. ADAM12 is a costimulatory molecule that determines Th1 cell fate and mediates tissue inflammation
    Authors: Y Liu, R Bockermann, M Hadi, I Safari, B Carrion, M Kveiborg, S Issazadeh-
    Cell. Mol. Immunol., 2020;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  98. Immunoglobulin Class Switch Recombination is initiated by rare cytosine deamination events at switch regions
    Authors: A Kim, L Han, K Yu
    Mol. Cell. Biol., 2020;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  99. Transient Receptor Potential Vanilloid channel regulates fibroblast differentiation and airway remodeling by modulating redox signals through NADPH Oxidase 4
    Authors: N Al-Azzam, LR Teegala, S Pokhrel, S Ghebreigzi, T Chachkovsk, S Thodeti, I Gavilanes, K Covington, CK Thodeti, S Paruchuri
    Sci Rep, 2020;10(1):9827.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  100. Methylation in pericytes after acute injury promotes chronic kidney disease
    Authors: YH Chou, SY Pan, YH Shao, HM Shih, SY Wei, CF Lai, WC Chiang, C Schrimpf, KC Yang, LC Lai, YM Chen, TS Chu, SL Lin
    J. Clin. Invest., 2020;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  101. Differential regulation of Lipocalin 2 (LCN2) in doxorubicin-resistant 4T1 triple negative breast cancer cells
    Authors: SK Meurer, O Tezcan, T Lammers, R Weiskirche
    Cell. Signal., 2020;74(0):109731.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  102. Cancer-associated fibroblasts downregulate type I interferon receptor to stimulate intratumoral stromagenesis
    Authors: C Cho, R Mukherjee, AR Peck, Y Sun, N McBrearty, KV Katlinski, J Gui, PK Govindaraj, E Puré, H Rui, SY Fuchs
    Oncogene, 2020;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  103. Functional Radiogenetic Profiling Implicates ERCC6L2 in Non-homologous End Joining
    Authors: P Francica, M Mutlu, VA Blomen, C Oliveira, Z Nowicka, A Trenner, NM Gerhards, P Bouwman, E Stickel, ML Hekkelman, L Lingg, I Klebic, M van de Ven, R de Korte-G, D Howald, J Jonkers, AA Sartori, W Fendler, JR Chapman, T Brummelkam, S Rottenberg
    Cell Rep, 2020;32(8):108068.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  104. Nintedanib promotes antitumour immunity and shows antitumour activity in combination with PD-1 blockade in mice: potential role of cancer-associated fibroblasts
    Authors: R Kato, K Haratani, H Hayashi, K Sakai, H Sakai, H Kawakami, K Tanaka, M Takeda, K Yonesaka, K Nishio, K Nakagawa
    British Journal of Cancer, 2020;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  105. B Cell Endosomal RAB7 Promotes TRAF6 K63 Polyubiquitination and NF-kappaB Activation for Antibody Class-Switching
    Authors: H Yan, M Fernandez, J Wang, S Wu, R Wang, Z Lou, JB Moroney, CE Rivera, JR Taylor, H Gan, H Zan, D Kolvaskyy, D Liu, P Casali, Z Xu
    J. Immunol., 2020;204(5):1146-1157.
    Species: Transgenic Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  106. PPP2R2D suppresses interleukin-2 production and regulatory T cell function
    Authors: W Pan, A Sharabi, AP Ferretti, Y Zhang, C Burbano, N Yoshida, MG Tsokos, GC Tsokos
    JCI Insight, 2020;5(19):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  107. Macrophage to myofibroblast transition contributes to subretinal fibrosis secondary to neovascular age-related macular degeneration
    Authors: K Little, M Llorián-Sa, M Tang, X Du, S Marry, M Chen, H Xu
    J Neuroinflammation, 2020;17(1):355.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  108. A Novel Selective Sphingosine Kinase 2 Inhibitor, HWG-35D, Ameliorates the Severity of Imiquimod-Induced Psoriasis Model by Blocking Th17 Differentiation of Na�ve CD4 T Lymphocytes
    Authors: SH Shin, HY Kim, HS Yoon, WJ Park, DR Adams, NJ Pyne, S Pyne, JW Park
    Int J Mol Sci, 2020;21(21):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  109. Exogenous bone marrow derived-putative endothelial progenitor cells attenuate ischemia reperfusion-induced vascular injury and renal fibrosis in mice dependent on pericytes
    Authors: M Wang, H Xu, Y Li, C Cao, H Zhu, Y Wang, Z Zhao, G Pei, F Zhu, Q Yang, X Deng, C Zhou, Y Guo, J Wu, W Liao, J Yang, Y Yao, R Zeng
    Theranostics, 2020;10(26):12144-12157.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  110. Androgens Accentuate TGF-&beta Dependent Erk/Smad Activation During Thoracic Aortic Aneurysm Formation in Marfan Syndrome Male Mice
    Authors: Y Tashima, H He, JZ Cui, AJ Pedroza, K Nakamura, N Yokoyama, C Iosef, G Burdon, T Koyano, A Yamaguchi, MP Fischbein
    J Am Heart Assoc, 2020;9(20):e015773.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  111. Synthetic Prostacyclin Agonist Attenuates Pressure-Overloaded Cardiac Fibrosis by Inhibiting FMT
    Authors: K Masada, S Miyagawa, Y Sakai, A Harada, T Kanaya, Y Sawa
    Mol Ther Methods Clin Dev, 2020;19(0):210-219.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  112. B7-H4 Inhibits the Development of Primary Sj�gren's Syndrome by Regulating Treg Differentiation in NOD/Ltj Mice
    Authors: X Zheng, Q Wang, X Yuan, Y Zhou, H Chu, G Wang, X Li, Y Wang, L Wei, L Wang, X Li
    J Immunol Res, 2020;2020(0):4896727.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  113. Mifepristone Treatment Promotes Testicular Leydig Cell Tumor Progression in Transgenic Mice
    Authors: D Ponikwicka, M Chrusciel, K Pulawska, P Bernaczyk, M Sztachelsk, P Guo, X Li, J Toppari, IT Huhtaniemi, S Wo?czy?ski, NA Rahman
    Cancers (Basel), 2020;12(11):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  114. Legumain is a predictor of all-cause mortality and potential therapeutic target in acute myocardial infarction
    Authors: H Yang, Y He, P Zou, Y Hu, X Li, L Tang, Z Zhu, S Tai, T Tu, Y Xiao, M Chen, C Wu, S Zhou
    Cell Death Dis, 2020;11(11):1014.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  115. Pirfenidone prevents and reverses hepatic insulin resistance and steatohepatitis by polarizing M2 macrophages
    Authors: G Chen, Y Ni, N Nagata, L Xu, F Zhuge, M Nagashimad, S Kaneko, T Ota
    Lab. Invest., 2019;0(0):.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  116. Enhanced glycolytic metabolism supports transmigration of brain-infiltrating macrophages in multiple sclerosis
    Authors: DK Kaushik, A Bhattachar, R Mirzaei, KS Rawji, Y Ahn, JM Rho, VW Yong
    J. Clin. Invest., 2019;130(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  117. Foxp1 is critical for the maintenance of regulatory T-cell homeostasis and suppressive function
    Authors: J Ren, L Han, J Tang, Y Liu, X Deng, Q Liu, P Hao, X Feng, B Li, H Hu, H Wang
    PLoS Biol., 2019;17(5):e3000270.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  118. Activation of aryl hydrocarbon receptor signaling by a novel agonist ameliorates autoimmune encephalomyelitis
    Authors: A Abdullah, M Maged, I Hairul-Isl, A Osama I, H Maha, A Manal, H Hamza
    PLoS ONE, 2019;14(4):e0215981.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  119. Pharmacological inhibition of ?-catenin/BCL9 interaction overcomes resistance to immune checkpoint blockades by modulating Treg cells
    Authors: M Feng, JQ Jin, L Xia, T Xiao, S Mei, X Wang, X Huang, J Chen, M Liu, C Chen, S Rafi, AX Zhu, YX Feng, D Zhu
    Sci Adv, 2019;5(5):eaau5240.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  120. Cutting Edge: ATM Influences Germinal Center Integrity
    Authors: L Nicolas, M Cols, R Smolkin, KC Fernandez, WT Yewdell, WF Yen, S Zha, BQ Vuong, J Chaudhuri
    J. Immunol., 2019;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  121. Putative endothelial progenitor cells do not promote vascular repair but attenuate pericyte-myofibroblast transition in UUO-induced renal fibrosis
    Authors: J Yang, M Wang, F Zhu, J Sun, H Xu, OL Chong Lee, Z Zhao, G Pei, H Zhu, C Cao, X He, Y Huang, Z Ma, L Liu, L Wang, Y Ning, W Liu, G Xu, X Wang, R Zeng, Y Yao
    Stem Cell Res Ther, 2019;10(1):104.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  122. Estrogen receptor ? in T cells suppresses follicular helper T cell responses and prevents autoimmunity
    Authors: DH Kim, HJ Park, HS Park, JU Lee, C Ko, MC Gye, JM Choi
    Exp. Mol. Med., 2019;51(4):41.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  123. Targeting of dermal myofibroblasts through death receptor 5 arrests fibrosis in mouse models of scleroderma
    Authors: JS Park, Y Oh, YJ Park, O Park, H Yang, S Slania, LK Hummers, AA Shah, HT An, J Jang, MR Horton, J Shin, HC Dietz, E Song, DH Na, EJ Park, K Kim, KC Lee, VV Roschke, J Hanes, MG Pomper, S Lee
    Nat Commun, 2019;10(1):1128.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  124. miRNA profiling of urinary exosomes to assess the progression of acute kidney injury
    Authors: H Sonoda, BR Lee, KH Park, D Nihalani, JH Yoon, M Ikeda, SH Kwon
    Sci Rep, 2019;9(1):4692.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  125. DGAT1 inhibits retinol-dependent regulatory T cell formation and mediates autoimmune encephalomyelitis
    Authors: KL Graham, BJ Werner, KM Moyer, AK Patton, CR Krois, HS Yoo, M Tverskoy, M LaJevic, JL Napoli, RA Sobel, BA Zabel, EC Butcher
    Proc. Natl. Acad. Sci. U.S.A., 2019;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  126. Pathogenic function of bystander-activated memory-like CD4+ T cells in autoimmune encephalomyelitis
    Authors: HG Lee, JU Lee, DH Kim, S Lim, I Kang, JM Choi
    Nat Commun, 2019;10(1):709.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  127. Salvia miltiorrhiza and Carthamus tinctorius Extract Prevents Cardiac Fibrosis and Dysfunction after Myocardial Infarction by Epigenetically Inhibiting Smad3 Expression
    Authors: J Yang, B Wang, N Li, Q Zhou, W Zhou, Z Zhan
    Evid Based Complement Alternat Med, 2019;2019(0):6479136.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  128. Gas6 Prevents Epithelial-Mesenchymal Transition in Alveolar Epithelial Cells via Production of PGE2, PGD2 and Their Receptors
    Authors: J Jung, YJ Lee, YH Choi, EM Park, HS Kim, JL Kang
    Cells, 2019;8(7):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  129. TGFbeta-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis
    Authors: J Li, A Ayoub, Y Xiu, X Yin, JO Sanders, A Mesfin, L Xing, Z Yao, BF Boyce
    Nat Commun, 2019;10(1):2795.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  130. 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine derivatives as inhibitors of full-length RORγt
    Authors: C Lao, X Zhou, H Chen, F Wei, Z Huang, C Bai
    Bioorg. Chem., 2019;90(0):103077.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  131. Label-free quantitative proteomics identifies transforming growth factorβ1 (TGF-?1) as an inhibitor of adipogenic transformation in OP9-DL1 cells and primary thymic stromal cells
    Authors: J Tan, Y Wang, S Wang, S Wu, Z Yuan, X Zhu
    Cell Biosci, 2019;9(0):48.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ChIP
  132. Ablation of RhoA impairs Th17 cell differentiation and alleviates house dust mite-triggered allergic airway inflammation
    Authors: JQ Yang, KW Kalim, Y Li, Y Zheng, F Guo
    J. Leukoc. Biol., 2019;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  133. Identification of a pro-angiogenic functional role for FSP1-positive fibroblast subtype in wound healing
    Authors: S Saraswati, SMW Marrow, LA Watch, PP Young
    Nat Commun, 2019;10(1):3027.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  134. Blocking interleukin-6 trans-signaling protects against renal fibrosis by suppressing STAT3 activation
    Authors: W Chen, H Yuan, W Cao, T Wang, W Chen, H Yu, Y Fu, B Jiang, H Zhou, H Guo, X Zhao
    Theranostics, 2019;9(14):3980-3991.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  135. Salvia miltiorrhiza and Carthamus tinctorius Extract Prevents Cardiac Fibrosis and Dysfunction after Myocardial Infarction by Epigenetically Inhibiting Smad3 Expression
    Authors: J Yang, B Wang, N Li, Q Zhou, W Zhou, Z Zhan
    Evid Based Complement Alternat Med, 2019;2019(0):6479136.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  136. Inhibition of Rho-Kinase Downregulates Th17 Cells and Ameliorates Hepatic Fibrosis by Schistosoma japonicum Infection
    Authors: W Zhou, Y Yang, C Mei, P Dong, S Mu, H Wu, Y Zhou, Y Zheng, F Guo, JQ Yang
    Cells, 2019;8(10):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  137. Does co-transplantation of mesenchymal and spermatogonial stem cells improve reproductive efficiency and safety in mice?
    Authors: P Kadam, E Ntemou, J Onofre, D Van Saen, E Goossens
    Stem Cell Res Ther, 2019;10(1):310.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  138. Fibulin-1c regulates transforming growth factor-beta activation in pulmonary tissue fibrosis
    Authors: G Liu, MA Cooley, AG Jarnicki, T Borghuis, PM Nair, G Tjin, AC Hsu, TJ Haw, M Fricker, CL Harrison, B Jones, NG Hansbro, PA Wark, JC Horvat, WS Argraves, BG Oliver, DA Knight, JK Burgess, PM Hansbro
    JCI Insight, 2019;5(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  139. Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation
    Authors: AA Lombardi, AA Gibb, E Arif, DW Kolmetzky, D Tomar, TS Luongo, P Jadiya, EK Murray, PK Lorkiewicz, G Hajnóczky, E Murphy, ZP Arany, DP Kelly, KB Margulies, BG Hill, JW Elrod
    Nat Commun, 2019;10(1):4509.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  140. Impact of aging on transition of acute kidney injury to chronic kidney disease
    Authors: MG Kim, J Yang, YS Ko, HY Lee, SW Oh, WY Cho, SK Jo
    Sci Rep, 2019;9(1):18445.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  141. Oral flavonoid fisetin treatment protects against prolonged high-fat-diet-induced cardiac dysfunction by regulation of multicombined signaling
    Authors: LF Hu, J Feng, X Dai, Y Sun, M Xiong, L Lai, S Zhong, C Yi, G Chen, H Li, Q Yang, Q Kuang, T Long, J Zhan, T Tang, C Ge, J Tan, M Xu
    J. Nutr. Biochem., 2019;77(0):108253.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  142. Tangeretin attenuates lipopolysaccharide-induced acute lung injury through Notch signaling pathway via suppressing Th17?cell response in mice
    Authors: M Li, Y Zhao, D Qi, J He, D Wang
    Microb. Pathog., 2019;138(0):103826.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  143. The Spinal Transcriptome after Cortical Stroke: In Search of Molecular Factors Regulating Spontaneous Recovery in the Spinal Cord
    Authors: J Kaiser, M Maibach, I Salpeter, N Hagenbuch, VBC de Souza, MD Robinson, ME Schwab
    J. Neurosci., 2019;39(24):4714-4726.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  144. The Tec kinase ITK is essential for ILC2 survival and epithelial integrity in the intestine
    Authors: HS Cho, A Reboldi, JA Hall, LJ Berg
    Nat Commun, 2019;10(1):784.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  145. MYMD-1, a Novel Immunometabolic Regulator, Ameliorates Autoimmune Thyroiditis via Suppression of Th1 Responses and TNF-? Release
    Authors: G Di Dalmazi, P Chalan, P Caturegli
    J. Immunol., 2019;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  146. Microglia are an essential component of the neuroprotective scar that forms after spinal cord injury
    Authors: V Bellver-La, F Bretheau, B Mailhot, N Vallières, M Lessard, ME Janelle, N Vernoux, MÈ Tremblay, T Fuehrmann, MS Shoichet, S Lacroix
    Nat Commun, 2019;10(1):518.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  147. Resolution of Cutaneous Leishmaniasis and Persistence of Leishmania major in the Absence of Arginase 1
    Authors: K Paduch, A Debus, B Rai, U Schleicher, C Bogdan
    J. Immunol., 2019;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  148. Inhibins regulate peripheral regulatory T cell induction through modulation of dendritic cell function
    Authors: M de la Fuen, R Olguín-Alo, S Ortega-Fra, LC Bonifaz, G Soldevila
    FEBS Open Bio, 2019;9(1):137-147.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  149. Comparing Effects of Transforming Growth Factor ?1 on Microglia From Rat and Mouse: Transcriptional Profiles and Potassium Channels
    Authors: S Lively, D Lam, R Wong, LC Schlichter
    Front Cell Neurosci, 2018;12(0):115.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  150. Galectin-9 is Critical for Mucosal Adaptive Immunity through the TH17-IgA Axis
    Authors: CC Liang, CS Li, IC Weng, HY Chen, HH Lu, CC Huang, FT Liu
    Am. J. Pathol., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  151. Fatty acid synthase is required for profibrotic TGF-? signaling
    Authors: MY Jung, JH Kang, DM Hernandez, X Yin, M Andrianifa, Y Wang, A Gonzalez-G, AH Limper, R Lupu, EB Leof
    FASEB J., 2018;0(0):fj201701187R.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  152. RAGE Deletion Confers Renoprotection by Reducing Responsiveness to Transforming Growth Factor-? and Increasing Resistance to Apoptosis
    Authors: S Hagiwara, K Sourris, M Ziemann, W Tieqiao, M Mohan, AD McClelland, E Brennan, J Forbes, M Coughlan, B Harcourt, S Penfold, B Wang, G Higgins, R Pickering, A El-Osta, MC Thomas, ME Cooper, P Kantharidi
    Diabetes, 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  153. OX40 Costimulation Inhibits Foxp3 Expression and Treg Induction via BATF3-Dependent and Independent Mechanisms
    Authors: X Zhang, X Xiao, P Lan, J Li, Y Dou, W Chen, N Ishii, S Chen, B Xia, K Chen, E Taparowsky, XC Li
    Cell Rep, 2018;24(3):607-618.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  154. Notch ligand Delta-like 4 induces epigenetic regulation of Treg cell differentiation and function in viral infection
    Authors: HA Ting, D de Almeida, AJ Rasky, CA Malinczak, IP Maillard, MA Schaller, NW Lukacs
    Mucosal Immunol, 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  155. Hedgehog Interacting Protein Promotes Fibrosis and Apoptosis in Glomerular Endothelial Cells in Murine Diabetes
    Authors: XP Zhao, SY Chang, MC Liao, CS Lo, I Chenier, H Luo, JL Chiasson, JR Ingelfinge, JSD Chan, SL Zhang
    Sci Rep, 2018;8(1):5958.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  156. DW2008S and its major constituents from Justicia procumbens exert anti-asthmatic effect via multitargeting activity
    Authors: J Youm, H Lee, Y Choi, J Yoon
    J. Cell. Mol. Med., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  157. Neer Award 2018: Platelet-derived growth factor receptor α co-expression typifies a subset of platelet-derived growth factor receptor β-positive progenitor cells that contribute to fatty degeneration and fibrosis of the murine rotator cuff
    Authors: AR Jensen, BV Kelley, GM Mosich, A Ariniello, CD Eliasberg, B Vu, P Shah, SK Devana, IR Murray, B Péault, A Dar, FA Petriglian
    J Shoulder Elbow Surg, 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  158. Collagen-derived peptides modulate CD4T-cell differentiation and suppress allergic responses in mice
    Authors: A Nishikimi, YI Koyama, S Ishihara, S Kobayashi, C Tometsuka, M Kusubata, K Kuwaba, O Hayashida, S Hattori, K Katagiri
    Immun Inflamm Dis, 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  159. Tumor-Induced Generation of Splenic Erythroblast-like Ter-Cells Promotes Tumor Progression
    Authors: Y Han, Q Liu, J Hou, Y Gu, Y Zhang, Z Chen, J Fan, W Zhou, S Qiu, Y Zhang, T Dong, N Li, Z Jiang, H Zhu, Q Zhang, Y Ma, L Zhang, Q Wang, Y Yu, N Li, X Cao
    Cell, 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  160. Transcription factor scleraxis vitally contributes to progenitor lineage direction in wound healing of adult tendon in mice
    Authors: T Sakabe, K Sakai, T Maeda, A Sunaga, N Furuta, R Schweitzer, T Sasaki, T Sakai
    J. Biol. Chem., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  161. Cross-Inhibition of Norrin and TGF-? Signaling Modulates Development of Retinal and Choroidal Vasculature
    Authors: R Seitz, G Weber, S Albrecht, R Fuchshofer, ER Tamm, A Ohlmann
    Invest. Ophthalmol. Vis. Sci., 2018;59(6):2240-2251.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  162. DNA double-strand break response factors influence end-joining features of IgH class switch and general translocation junctions
    Authors: RA Panchaksha, X Zhang, V Kumar, Z Du, PC Wei, J Kao, J Dong, FW Alt
    Proc. Natl. Acad. Sci. U.S.A., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  163. The H2B deubiquitinase Usp22 promotes antibody class switch recombination by facilitating non-homologous end joining
    Authors: C Li, T Irrazabal, CC So, M Berru, L Du, E Lam, AK Ling, JL Gommerman, Q Pan-Hammar, A Martin
    Nat Commun, 2018;9(1):1006.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  164. Characterization and allergic role of IL-33-induced neutrophil polarization
    Authors: B Sun, L Zhu, Y Tao, HX Sun, Y Li, P Wang, Y Hou, Y Zhao, X Zhang, L Zhang, N Na, Y Zhao
    Cell. Mol. Immunol., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  165. Intraperitoneal infusion of mesenchymal stem cell attenuates severity of collagen antibody induced arthritis
    Authors: Y Nam, SM Jung, YA Rim, H Jung, K Lee, N Park, J Kim, Y Jang, YB Park, SH Park, JH Ju
    PLoS ONE, 2018;13(6):e0198740.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  166. Celastrol mediates Th17 and Treg cell generation via metabolic signaling
    Authors: J Zhang, J Shan, X Chen, S Li, D Long, Y Li
    Biochem. Biophys. Res. Commun., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  167. Mesenchymal stem cells ameliorate experimental arthritis via expression of interleukin-1 receptor antagonist
    Authors: K Lee, N Park, H Jung, YA Rim, Y Nam, J Lee, SH Park, JH Ju
    PLoS ONE, 2018;13(2):e0193086.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  168. Fas Promotes T Helper 17 Cell Differentiation and Inhibits T Helper 1 Cell Development by Binding and Sequestering Transcription Factor STAT1
    Authors: G Meyer Zu H, D Przybylski, MA Schramm, C Wang, A Schnell, Y Lee, R Sobel, A Regev, VK Kuchroo
    Immunity, 2018;48(3):556-569.e7.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  169. Rab4b Deficiency in T Cells Promotes Adipose Treg/Th17 Imbalance, Adipose Tissue Dysfunction, and Insulin Resistance
    Authors: J Gilleron, G Bouget, S Ivanov, C Meziat, F Ceppo, B Vergoni, M Djedaini, A Soprani, K Dumas, A Jacquel, L Yvan-Charv, N Venteclef, JF Tanti, M Cormont
    Cell Rep, 2018;25(12):3329-3341.e5.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  170. Elevated extracellular calcium ions promote proliferation and migration of mesenchymal stem cells via increasing osteopontin expression
    Authors: MN Lee, HS Hwang, SH Oh, A Roshanzade, JW Kim, JH Song, ES Kim, JT Koh
    Exp. Mol. Med., 2018;50(11):142.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  171. TRPV4 regulates matrix stiffness and TGF?1-induced epithelial-mesenchymal transition
    Authors: S Sharma, R Goswami, DX Zhang, SO Rahaman
    J. Cell. Mol. Med., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  172. Lung fibroblasts express a miR-19a-19b-20a sub-cluster to suppress TGF-?-associated fibroblast activation in murine pulmonary fibrosis
    Authors: K Souma, S Shichino, S Hashimoto, S Ueha, T Tsukui, T Nakajima, HI Suzuki, FHW Shand, Y Inagaki, T Nagase, K Matsushima
    Sci Rep, 2018;8(1):16642.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  173. Hexokinase II may be dispensable for CD4 T cell responses against a virus infection
    Authors: SK Varanasi, U Jaggi, N Hay, BT Rouse
    PLoS ONE, 2018;13(1):e0191533.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  174. Co-transplantation of mesenchymal stem cells improves spermatogonial stem cell transplantation efficiency in mice
    Authors: P Kadam, E Ntemou, Y Baert, S Van Laere, D Van Saen, E Goossens
    Stem Cell Res Ther, 2018;9(1):317.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  175. TGF-?-Induced CD8CD103Regulatory T Cells Show Potent Therapeutic Effect on Chronic Graft-versus-Host Disease Lupus by Suppressing B Cells
    Authors: H Zhong, Y Liu, Z Xu, P Liang, H Yang, X Zhang, J Zhao, J Chen, S Fu, Y Tang, J Lv, J Wang, N Olsen, A Xu, SG Zheng
    Front Immunol, 2018;9(0):35.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  176. Microbiota-driven interleukin-17-producing cells and eosinophils synergize to accelerate multiple myeloma progression
    Authors: A Calcinotto, A Brevi, M Chesi, R Ferrarese, L Garcia Per, M Grioni, S Kumar, VM Garbitt, ME Sharik, KJ Henderson, G Tonon, M Tomura, Y Miwa, E Esplugues, RA Flavell, S Huber, F Canducci, VS Rajkumar, PL Bergsagel, M Bellone
    Nat Commun, 2018;9(1):4832.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  177. Reduced production of laminin by hepatic stellate cells contributes to impairment in oval cell response to liver injury in aged mice
    Authors: L Qian, H Zhang, Y Gu, D Li, S He, H Wang, Y Cheng, W Yang, H Yu, X Zhao, W Cai, L Meng, M Jin, Y Wang, Y Zhang
    Aging (Albany NY), 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  178. Attenuation of pulmonary fibrosis in type I collagen-targeted reporter mice with ALK-5 inhibitors
    Authors: H Terashima, M Aonuma, H Tsuchida, K Sugimoto, M Yokoyama, M Kato
    Pulm Pharmacol Ther, 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  179. The shieldin complex mediates 53BP1-dependent DNA repair
    Authors: SM Noordermee, S Adam, D Setiaputra, M Barazas, SJ Pettitt, AK Ling, M Olivieri, A Álvarez-Qu, N Moatti, M Zimmermann, S Annunziato, DB Krastev, F Song, I Brandsma, J Frankum, R Brough, A Sherker, S Landry, RK Szilard, MM Munro, A McEwan, T Goullet de, ZY Lin, T Hart, J Moffat, AC Gingras, A Martin, H van Attiku, J Jonkers, CJ Lord, S Rottenberg, D Durocher
    Nature, 2018;560(7716):117-121.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  180. Transforming growth factor-?1 up-regulates connexin43 expression in osteocytes via canonical Smad-dependent signaling pathway
    Authors: W Liu, Y Cui, J Sun, L Cai, J Xie, X Zhou
    Biosci. Rep., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  181. ILDR2-Fc Is a Novel Regulator of Immune Homeostasis and Inducer of Antigen-Specific Immune Tolerance
    Authors: JR Podojil, I Hecht, MY Chiang, I Vaknin, I Barbiro, A Novik, E Neria, G Rotman, SD Miller
    J. Immunol., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  182. Leukotriene B4 promotes neovascularization and macrophage recruitment in murine wet-type AMD models
    Authors: F Sasaki, T Koga, M Ohba, K Saeki, T Okuno, K Ishikawa, T Nakama, S Nakao, S Yoshida, T Ishibashi, H Ahmadieh, MR Kanavi, A Hafezi-Mog, JM Penninger, KH Sonoda, T Yokomizo
    JCI Insight, 2018;3(18):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  183. GLK-IKK? signaling induces dimerization and translocation of the AhR-ROR?t complex in IL-17A induction and autoimmune disease
    Authors: HC Chuang, CY Tsai, CH Hsueh, TH Tan
    Sci Adv, 2018;4(9):eaat5401.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  184. Differential Phagocytic Properties of CD45lowMicroglia and CD45highBrain Mononuclear Phagocytes-Activation and Age-Related Effects
    Authors: S Rangaraju, SA Raza, NX Li, R Betarbet, EB Dammer, D Duong, JJ Lah, NT Seyfried, AI Levey
    Front Immunol, 2018;9(0):405.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  185. Interferon-gamma inhibits seminal plasma induction of colony stimulating factor 2 in mouse and human reproductive tract epithelial cells
    Authors: DJ Sharkey, DJ Glynn, JE Schjenken, KP Tremellen, SA Robertson
    Biol. Reprod., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  186. Interleukin-17A-promoted MSC2 polarization related with new bone formation of ankylosing spondylitis
    Authors: T He, Y Huang, C Zhang, D Liu, C Cheng, W Xu, X Zhang
    Oncotarget, 2017;8(57):96993-97008.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  187. BJ-1108, a 6-Amino-2,4,5-trimethylpyridin-3-ol analogue, regulates differentiation of Th1 and Th17 cells to ameliorate experimental autoimmune encephalomyelitis
    Authors: Y Kang, M Timilshina, TG Nam, BS Jeong, JH Chang
    Biol. Res, 2017;50(1):8.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  188. Interferon-gamma regulates inflammatory cell death by targeting necroptosis in experimental autoimmune arthritis
    Authors: SH Lee, JY Kwon, SY Kim, K Jung, ML Cho
    Sci Rep, 2017;7(1):10133.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  189. Balanced Bcl-3 expression in murine CD4(+) T cells is required for generation of encephalitogenic Th17 cells
    Authors: IA Mufazalov, J Kuschmann, D Andruszews, J Masri, LA Gabriel, P Adams, S Reissig, N Hövelmeyer, A Waisman
    Eur. J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  190. Bi-layered constructs of poly(glycerol-sebacate)-?-tricalcium phosphate for bone-soft tissue interface applications
    Authors: Atakan Tevlek
    Mater Sci Eng C Mater Biol Appl, 2017;72(0):316-324.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  191. mTORC2 controls Th9 polarization and allergic airway inflammation
    Authors: H Chen, L Zhang, P Wang, H Su, W Wang, Z Chu, L Zhang, X Zhang, Y Zhao
    Allergy, 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  192. Interleukin 4 receptor-targeted pro-apoptotic peptide blocks tumor growth and metastasis by enhancing anti-tumor immunity
    Authors: SMP Vadevoo, JE Kim, GR Gunassekar, HK Jung, L Chi, DE Kim, SH Lee, SH Im, B Lee
    Mol. Cancer Ther., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  193. The frequency of Th17�cells in the small intestine exhibits a day-night variation dependent on circadian clock activity
    Authors: HP Thu Le, Y Nakamura, K Oh-Oka, K Ishimaru, S Nakajima, A Nakao
    Biochem. Biophys. Res. Commun., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  194. Estrogen modulates mesenchymal-epidermal interactions in the adult nipple
    Authors: HJ Wu, JW Oh, DF Spandau, S Tholpady, J Diaz, LJ Schroeder, CD Offutt, AB Glick, MV Plikus, S Koyama, J Foley
    Development, 2017;0(0):.
    Species: Mouse
    Sample Types: Complex Sample Type
    Applications: In Vivo
  195. Bone-induced expression of integrin ?3 enables targeted nanotherapy of breast cancer metastases
    Authors: MH Ross, AK Esser, GC Fox, AH Schmieder, X Yang, G Hu, D Pan, X Su, Y Xu, DV Novack, T Walsh, GA Colditz, GH Lukaszewic, E Cordell, JS Novack, JAJ Fitzpatric, DL Waning, KS Mohammad, TA Guise, GM Lanza, KN Weilbaeche
    Cancer Res., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  196. Selective degradation of PU.1 during autophagy represses the differentiation and antitumour activity of TH9 cells
    Authors: T Rivera Var, Z Cai, Y Shen, M Dosset, I Benoit-Liz, T Martin, A Roussey, RA Flavell, F Ghiringhel, L Apetoh
    Nat Commun, 2017;8(1):559.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  197. Absence of Notch1 in murine myeloid cells attenuates the development of experimental autoimmune encephalomyelitis by affecting Th1 and Th17 priming
    Authors: M Fernández, EM Monsalve, S López-Lópe, A Ruiz-Garcí, S Mellado, E Caminos, JJ García-Ram, J Laborda, P Tranque, MJM Díaz-Guerr
    Eur. J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  198. Expression of antisense of microRNA-26a-5p in mesenchymal stem cells increases their therapeutic effects against cirrhosis
    Authors: L Chen, W Zeng, B Yang, X Cui, C Feng, L Wang, H Wang, X Zhou, P Li, F Lv, T Li
    Am J Transl Res, 2017;9(3):1500-1508.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  199. BJ-2266 ameliorates experimental autoimmune encephalomyelitis through down-regulation of the JAK/STAT signaling pathway
    Authors: Z You, M Timilshina, BS Jeong, JH Chang
    Eur. J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  200. Inhibition of ubiquitin-specific protease 34 (USP34) induces epithelial-mesenchymal transition and promotes stemness in mammary epithelial cells
    Authors: E Oh, JY Kim, D Sung, Y Cho, N Lee, H An, YJ Kim, TM Cho, JH Seo
    Cell. Signal., 2017;36(0):230-239.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  201. Suppressive IL-17A(+)Foxp3(+) and ex-Th17 IL-17A(neg)Foxp3(+) Treg cells are a source of tumour-associated Treg cells
    Authors: S Downs-Cann, S Berkey, GM Delgoffe, RP Edwards, T Curiel, K Odunsi, DL Bartlett, N Obermajer
    Nat Commun, 2017;8(0):14649.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  202. TLR7 Signaling Regulates Th17 Cells and Autoimmunity: Novel Potential for Autoimmune Therapy
    Authors: J Ye, Y Wang, X Liu, L Li, A Opejin, EC Hsueh, H Luo, T Wang, D Hawiger, G Peng
    J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  203. Nuclear Proximity of Mtr4 to RNA Exosome Restricts DNA Mutational Asymmetry
    Authors: J Lim, PK Giri, D Kazadi, B Laffleur, W Zhang, V Grinstein, E Pefanis, LM Brown, E Ladewig, O Martin, Y Chen, R Rabadan, F Boyer, G Rothschild, M Cogné, E Pinaud, H Deng, U Basu
    Cell, 2017;169(3):523-537.e15.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  204. Signaling via Smad2 and Smad3 is dispensable for adult murine hematopoietic stem cell function in vivo
    Authors: M Billing, E Rörby, M Dahl, U Blank, S Andradottí, MM Matzuk, M Ehinger, S Karlsson
    Exp. Hematol., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  205. Mechanosignaling activation of TGF? maintains intervertebral disc homeostasis
    Authors: Q Bian, L Ma, A Jain, JL Crane, K Kebaish, M Wan, Z Zhang, X Edward Guo, PD Sponseller, CA Séguin, LH Riley, Y Wang, X Cao
    Bone Res, 2017;5(0):17008.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  206. CD73 promotes resistance to HER2/ErbB2 antibody therapy
    Authors: M Turcotte, D Allard, D Mittal, Y Bareche, L Buisseret, V Jose, S Pommey, V Delisle, S Loi, H Joensuu, PL Kellokumpu, C Sotiriou, MJ Smyth, J Stagg
    Cancer Res., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  207. The excretory-secretory products of Echinococcus granulosus protoscoleces directly regulate the differentiation of B10, B17 and Th17 cells
    Authors: W Pan, WT Hao, YJ Shen, XY Li, YJ Wang, FF Sun, JH Yin, J Zhang, RX Tang, JP Cao, KY Zheng
    Parasit Vectors, 2017;10(1):348.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  208. The long non-coding RNA GAS5 regulates TGF-?-induced smooth muscle cell differentiation via RNA-Smad binding element
    Authors: R Tang, G Zhang, YC Wang, X Mei, SY Chen
    J. Biol. Chem., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  209. Inhibiting Oxidative Phosphorylation In Vivo Restrains Th17 Effector Responses and Ameliorates Murine Colitis
    Authors: L Franchi, I Monteleone, LY Hao, MA Spahr, W Zhao, X Liu, K Demock, A Kulkarni, CA Lesch, B Sanchez, L Carter, I Marafini, X Hu, O Mashadova, M Yuan, JM Asara, H Singh, CA Lyssiotis, G Monteleone, AW Opipari, GD Glick
    J. Immunol, 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  210. Notch Balances Th17 and Induced Regulatory T Cell Functions in Dendritic Cells by Regulating Aldh1a2 Expression
    Authors: TS Zaman, H Arimochi, S Maruyama, C Ishifune, SI Tsukumo, A Kitamura, K Yasutomo
    J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  211. Local Inflammatory Cues Regulate Differentiation and Persistence of CD8(+) Tissue-Resident Memory T Cells
    Authors: T Bergsbaken, MJ Bevan, PJ Fink
    Cell Rep, 2017;19(1):114-124.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  212. Pirfenidone attenuates bleomycin-induced pulmonary fibrosis in mice by regulating Nrf2/Bach1 equilibrium
    Authors: Y Liu, F Lu, L Kang, Z Wang, Y Wang
    BMC Pulm Med, 2017;17(1):63.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  213. Manipulating Glucose Metabolism during Different Stages of Viral Pathogenesis Can Have either Detrimental or Beneficial Effects
    Authors: SK Varanasi, D Donohoe, U Jaggi, BT Rouse
    J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  214. Follistatin like-1 (Fstl1) is required for the normal formation of lung airway and vascular smooth muscle at birth
    Authors: X Liu, Y Liu, X Li, J Zhao, Y Geng, W Ning
    PLoS ONE, 2017;12(6):e0177899.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  215. Suppression of Th17 cell differentiation by misshapen/NIK-related kinase MINK1
    Authors: G Fu, Q Xu, Y Qiu, X Jin, T Xu, S Dong, J Wang, Y Ke, H Hu, X Cao, D Wang, H Cantor, X Gao, L Lu
    J. Exp. Med., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  216. IL-23 restoration of Th17 effector function is independent of IL-6 and TGF-? in a mouse model of alcohol and burn injury
    Authors: X Li, AR Cannon, AM Hammer, NL Morris, MA Choudhry
    J. Leukoc. Biol., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  217. Wolf-Hirschhorn Syndrome Candidate 1 Is Necessary for Correct Hematopoietic and B Cell Development
    Authors: E Campos-San, N Deleyto-Se, V Dominguez, E Carrillo-d, K Ura, PP Rocha, J Kim, A Aljoufi, A Esteve-Cod, M Dabad, M Gut, H Heyn, Y Kaneda, K Nimura, JA Skok, ML Martinez-F, C Cobaleda
    Cell Rep, 2017;19(8):1586-1601.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  218. Lamtor1 Is Critically Required for CD4(+) T Cell Proliferation and Regulatory T Cell Suppressive Function
    Authors: T Hosokawa, T Kimura, S Nada, T Okuno, D Ito, S Kang, S Nojima, K Yamashita, T Nakatani, Y Hayama, Y Kato, Y Kinehara, M Nishide, N Mikami, S Koyama, H Takamatsu, D Okuzaki, N Ohkura, S Sakaguchi, M Okada, A Kumanogoh
    J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  219. The Kielin/chordin-like Protein (KCP) Attenuates High Fat Diet Induced Obesity and Metabolic Syndrome in Mice
    Authors: A Soofi, KI Wolf, MP Emont, N Qi, G Martinez-S, E Grimley, W Ostwani, GR Dressler
    J. Biol. Chem., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  220. CYP4A in tumor-associated macrophages promotes pre-metastatic niche formation and metastasis
    Authors: XW Chen, TJ Yu, J Zhang, Y Li, HL Chen, GF Yang, W Yu, YZ Liu, XX Liu, CF Duan, HL Tang, M Qiu, CL Wang, H Zheng, J Yue, AM Guo, J Yang
    Oncogene, 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  221. Rad52 competes with Ku70/Ku86 for binding to S-region DSB ends to modulate antibody class-switch DNA recombination
    Authors: H Zan, C Tat, Z Qiu, JR Taylor, JA Guerrero, T Shen, P Casali
    Nat Commun, 2017;8(0):14244.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  222. NLRP3 signaling drives macrophage-induced adaptive immune suppression in pancreatic carcinoma
    Authors: D Daley, VR Mani, N Mohan, N Akkad, GSDB Pandian, S Savadkar, KB Lee, A Torres-Her, B Aykut, B Diskin, W Wang, MS Farooq, AI Mahmud, G Werba, EJ Morales, S Lall, BJ Wadowski, AG Rubin, ME Berman, R Narayanan, M Hundeyin, G Miller
    J. Exp. Med., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  223. Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition
    Authors: Cédric Blanpain
    Cell Stem Cell, 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  224. All Trans Retinoic Acid, Transforming Growth Factor ? and Prostaglandin E2 in Mouse Plasma Synergize with Basophil-Secreted Interleukin-4 to M2 Polarize Murine Macrophages
    PLoS ONE, 2016;11(12):e0168072.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  225. SiRNA-mediated in vivo gene knockdown by acid-degradable cationic nanohydrogel particles
    Authors: Nadine Leber
    J Control Release, 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  226. Alternative splicing of MALT1 controls signalling and activation of CD4(+) T cells
    Authors: I Meininger, RA Griesbach, D Hu, T Gehring, T Seeholzer, A Bertossi, J Kranich, A Oeckinghau, AC Eitelhuber, U Greczmiel, A Gewies, M Schmidt-Su, J Ruland, T Brocker, V Heissmeyer, F Heyd, D Krappmann
    Nat Commun, 2016;7(0):11292.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  227. Autonomous membrane IgE signaling prevents IgE-memory formation
    Nat Immunol, 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  228. GLUT-1-Dependent Glycolysis is Increased During Aging-related Lung Fibrosis and Phloretin Inhibits Lung Fibrosis
    Authors: Soo Jung Cho
    Am. J. Respir. Cell Mol. Biol, 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  229. Reduced TCR-dependent activation through citrullination of a T-cell epitope enhances Th17 development by disruption of the STAT3/5 balance
    Eur J Immunol, 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  230. Beta 1-integrin ligation and TLR ligation enhance GM-CSF-induced ALDH1A2 expression in dendritic cells, but differentially regulate their anti-inflammatory properties
    Sci Rep, 2016;6(0):37914.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  231. Pharmacologic modulation of ROR?t translates to efficacy in preclinical and translational models of psoriasis and inflammatory arthritis
    Sci Rep, 2016;6(0):37977.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  232. Attenuation of PKR-like ER Kinase (PERK) Signaling Selectively Controls Endoplasmic Reticulum Stress-induced Inflammation Without Compromising Immunological Responses
    Authors: LN Guthrie, K Abiraman, ES Plyler, NT Sprenkle, SA Gibson, BC McFarland, R Rajbhandar, AL Rowse, EN Benveniste, GP Meares
    J. Biol. Chem., 2016;291(30):15830-40.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  233. Young microglia restore amyloid plaque clearance of aged microglia
    Authors: Anna Daria
    EMBO J, 2016;0(0):.
    Species: Mouse
    Sample Types: Complex Sample Type
    Applications: Bioassay
  234. Affinity for self antigen selects Treg cells with distinct functional properties
    Nat Immunol, 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  235. Classical transient receptor potential 6 (TRPC6) channels support myofibroblast differentiation and development of experimental pulmonary fibrosis
    Authors: Katharina Hofmann
    Biochim. Biophys. Acta, 2016;1863(2):560-568.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  236. T cells are necessary for ILC2 activation in house dust mite-induced allergic airway inflammation in mice
    Authors: BW Li, MJ de Bruijn, I Tindemans, M Lukkes, A KleinJan, HC Hoogsteden, RW Hendriks
    Eur J Immunol, 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  237. Treatment of refractory cutaneous ulcers with mixed sheets consisting of peripheral blood mononuclear cells and fibroblasts
    Authors: Koji Ueno
    Sci Rep, 2016;6(0):28538.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  238. CD8+ T Cells and Endogenous IL-10 Are Required for Resolution of Chemotherapy-Induced Neuropathic Pain
    Authors: Annemieke Kavelaars
    J. Neurosci., 2016;36(43):11074-11083.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  239. Vimentin coordinates fibroblast proliferation and keratinocyte differentiation in wound healing via TGF-?-Slug signaling
    Proc Natl Acad Sci USA, 2016;113(30):E4320-7.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  240. Th1 cells downregulate connexin 43 gap junctions in astrocytes via microglial activation
    Sci Rep, 2016;6(0):38387.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  241. Differential effects of Pax3 on expression of polysialyltransferases STX and PST in TGF-?-treated normal murine mammary gland cells
    Exp Biol Med (Maywood), 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  242. Pharmacologic inhibition of Hsp90 to prevent GLT-1 degradation as an effective therapy for epilepsy
    Authors: Longze Sha
    J. Exp. Med, 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  243. Leptin directly promotes T-cell glycolytic metabolism to drive effector T-cell differentiation in a mouse model of autoimmunity
    Eur J Immunol, 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  244. Absence of miR-146a in podocytes increases risk of diabetic glomerulopathy via upregulation of erbb4 and notch-1
    Authors: Ha Won Lee
    J. Biol. Chem, 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  245. Restoration of Corneal Transparency by Mesenchymal Stem Cells
    Stem Cell Reports, 2016;7(4):583-590.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  246. The role of ?-smooth muscle actin in fibroblast-mediated matrix contraction and remodeling
    Authors: Nikolaos G Frangogian
    Biochim. Biophys. Acta, 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  247. Restoration of Corneal Transparency by Mesenchymal Stem Cells.
    Authors: Sharad K Mittal, Masahiro Omoto, Afsaneh Amouzegar, Anuradha Sahu, Alexandra Rezazadeh, Kishore R Katikired, Dhvanit I Shah, Srikant K Sahu, Sunil K Chauhan
    Stem Cell Reports, 2016;0(0):2213-6711.
    Species: Mouse
    Sample Types: Transfected Whole Cells
    Applications: Bioassay
  248. Regulatory T cell reprogramming toward a Th2-cell-like lineage impairs oral tolerance and promotes food allergy.
    Authors: Noval Rivas M, Burton O, Wise P, Charbonnier L, Georgiev P, Oettgen H, Rachid R, Chatila T
    Immunity, 2015;42(3):512-23.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  249. miR-148a is upregulated by Twist1 and T-bet and promotes Th1-cell survival by regulating the proapoptotic gene Bim.
    Authors: Haftmann C, Stittrich A, Zimmermann J, Fang Z, Hradilkova K, Bardua M, Westendorf K, Heinz G, Riedel R, Siede J, Lehmann K, Weinberger E, Zimmel D, Lauer U, Haupl T, Sieper J, Backhaus M, Neumann C, Hoffmann U, Porstner M, Chen W, Grun J, Baumgrass R, Matz M, Lohning M, Scheffold A, Wittmann J, Chang H, Rajewsky N, Jack H, Radbruch A, Mashreghi M
    Eur J Immunol, 2015;45(4):1192-205.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  250. Long non-coding RNAs (LncRNA) regulated by transforming growth factor (TGF) beta: LncRNA-hit-mediated TGFbeta-induced epithelial to mesenchymal transition in mammary epithelia.
    Authors: Richards E, Zhang G, Li Z, Permuth-Wey J, Challa S, Li Y, Kong W, Dan S, Bui M, Coppola D, Mao W, Sellers T, Cheng J
    J Biol Chem, 2015;290(11):6857-67.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  251. Mesenchymal stem/stromal cells protect against autoimmunity via CCL2-dependent recruitment of myeloid-derived suppressor cells.
    Authors: Lee H, Ko J, Jeong H, Ko A, Kim M, Wee W, Yoon S, Oh J
    J Immunol, 2015;194(8):3634-45.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  252. Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros-derived hematopoietic stem cells.
    Authors: Hadland B, Varnum-Finney B, Poulos M, Moon R, Butler J, Rafii S, Bernstein I
    J Clin Invest, 2015;125(5):2032-45.
    Species: Mouse
    Sample Types: Protein
    Applications: Bioassay
  253. Itk signals promote neuroinflammation by regulating CD4+ T-cell activation and trafficking.
    Authors: Kannan A, Kim D, August A, Bynoe M
    J Neurosci, 2015;35(1):221-33.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  254. Monocyte Chemoattractant Protein-Induced Protein 1 (MCPIP1) Enhances Angiogenic and Cardiomyogenic Potential of Murine Bone Marrow-Derived Mesenchymal Stem Cells.
    Authors: Labedz-Maslowska A, Lipert B, Berdecka D, Kedracka-Krok S, Jankowska U, Kamycka E, Sekula M, Madeja Z, Dawn B, Jura J, Zuba-Surma E
    PLoS ONE, 2015;10(7):e0133746.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  255. Retinoic acid can exacerbate T cell intrinsic TLR2 activation to promote tolerance.
    Authors: Nguyen, Vivien, Pearson, Kandyce, Kim, Jee-Hyun, Kamdar, Karishma, DePaolo, R Willia
    PLoS ONE, 2015;10(3):e0118875.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  256. Myocardin-related transcription factors control the motility of epicardium-derived cells and the maturation of coronary vessels.
    Authors: Trembley M, Velasquez L, de Mesy Bentley K, Small E
    Development, 2015;142(1):21-30.
  257. Novel mechanism of macrophage-mediated metastasis revealed in a zebrafish model of tumor development.
    Authors: Wang J, Cao Z, Zhang X, Nakamura M, Sun M, Hartman J, Harris R, Sun Y, Cao Y
    Cancer Res, 2015;75(2):306-15.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  258. A functional polymorphism of Ptpn22 is associated with type 1 diabetes in the BioBreeding rat.
    Authors: Sarmiento J, Wallis R, Ning T, Marandi L, Chao G, Veillette A, Lernmark A, Paterson A, Poussier P
    J Immunol, 2015;194(2):615-29.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  259. Impaired dendritic cell function in a spontaneous autoimmune polyneuropathy.
    Authors: Quan S, Kim H, Dukala D, Sheng J, Soliven B
    J Immunol, 2015;194(9):4175-84.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  260. ShcA regulates late stages of T cell development and peripheral CD4+ T cell numbers.
    Authors: Buckley M, Trampont P, Arandjelovic S, Fond A, Juncadella I, Ravichandran K
    J Immunol, 2015;194(4):1665-76.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  261. IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iTreg cell balance.
    Authors: Basu R, Whitley S, Bhaumik S, Zindl C, Schoeb T, Benveniste E, Pear W, Hatton R, Weaver C
    Nat Immunol, 2015;16(3):286-95.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  262. Beclin 1 regulates neuronal transforming growth factor-beta signaling by mediating recycling of the type I receptor ALK5.
    Authors: O'Brien C, Bonanno L, Zhang H, Wyss-Coray T
    Mol Neurodegener, 2015;10(1):69.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  263. Blocking follistatin-like 1 attenuates bleomycin-induced pulmonary fibrosis in mice.
    Authors: Dong Y, Geng Y, Li L, Li X, Yan X, Fang Y, Li X, Dong S, Liu X, Li X, Yang X, Zheng X, Xie T, Liang J, Dai H, Liu X, Yin Z, Noble P, Jiang D, Ning W
    J Exp Med, 2015;212(2):235-52.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  264. Testosterone suppresses hepatic inflammation by the downregulation of IL-17, CXCL-9, and CXCL-10 in a mouse model of experimental acute cholangitis.
    Authors: Schwinge D, Carambia A, Quaas A, Krech T, Wegscheid C, Tiegs G, Prinz I, Lohse A, Herkel J, Schramm C
    J Immunol, 2015;194(6):2522-30.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  265. Dendritic cell SIRT1-HIF1alpha axis programs the differentiation of CD4+ T cells through IL-12 and TGF-beta1.
    Authors: Liu G, Bi Y, Xue L, Zhang Y, Yang H, Chen X, Lu Y, Zhang Z, Liu H, Wang X, Wang R, Chu Y, Yang R
    Proc Natl Acad Sci U S A, 2015;112(9):E957-65.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  266. Blockade of IL-33 release and suppression of type 2 innate lymphoid cell responses by helminth secreted products in airway allergy.
    Authors: McSorley H, Blair N, Smith K, McKenzie A, Maizels R
    Mucosal Immunol, 2014;7(5):1068-78.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  267. TGF-beta and opioid receptor signaling crosstalk results in improvement of endogenous and exogenous opioid analgesia under pathological pain conditions.
    Authors: Lantero A, Tramullas M, Pilar-Cuellar F, Valdizan E, Santillan R, Roques B, Hurle M
    J Neurosci, 2014;34(15):5385-95.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  268. Toll-like receptor 9 mediated responses in cardiac fibroblasts.
    Authors: Ohm I, Alfsnes K, Belland Olsen M, Ranheim T, Sandanger O, Dahl T, Aukrust P, Finsen A, Yndestad A, Vinge L
    PLoS ONE, 2014;9(8):e104398.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  269. HIV Nef expression favors the relative preservation of CD4+ T regulatory cells that retain some important suppressive functions.
    Authors: Chrobak P, Afkhami S, Priceputu E, Poudrier J, Meunier C, Hanna Z, Sparwasser T, Jolicoeur P
    J Immunol, 2014;192(4):1681-92.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  270. Real-time imaging of the epithelial-mesenchymal transition using microRNA-200a sequence-based molecular beacon-conjugated magnetic nanoparticles.
    Authors: Choi Y, Kim H, Woo J, Hwang E, Cho K, Kim S, Moon W
    PLoS ONE, 2014;9(7):e102164.
    Species: Canine
    Sample Types: Whole Cells
    Applications: Bioassay
  271. The alarmin IL-33 promotes regulatory T-cell function in the intestine.
    Authors: Schiering C, Krausgruber T, Chomka A, Frohlich A, Adelmann K, Wohlfert E, Pott J, Griseri T, Bollrath J, Hegazy A, Harrison O, Owens B, Lohning M, Belkaid Y, Fallon P, Powrie F
    Nature, 2014;513(7519):564-8.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  272. Elongated TCR alpha chain CDR3 favors an altered CD4 cytokine profile.
    Authors: Reynolds C, Chong D, Raynsford E, Quigley K, Kelly D, Llewellyn-Hughes J, Altmann D, Boyton R
    BMC Biol, 2014;12(0):32.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  273. Attenuation of experimental colitis in glutathione peroxidase 1 and catalase double knockout mice through enhancing regulatory T cell function.
    Authors: Kim H, Lee A, Choi E, Kie J, Lim W, Lee H, Moon B, Seoh J
    PLoS ONE, 2014;9(4):e95332.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  274. The hippo pathway effector Yap controls patterning and differentiation of airway epithelial progenitors.
    Authors: Mahoney J, Mori M, Szymaniak A, Varelas X, Cardoso W
    Dev Cell, 2014;30(2):137-50.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  275. The transcription factor IRF8 activates integrin-mediated TGF-beta signaling and promotes neuroinflammation.
    Authors: Yoshida Y, Yoshimi R, Yoshii H, Kim D, Dey A, Xiong H, Munasinghe J, Yazawa I, O'Donovan M, Maximova O, Sharma S, Zhu J, Wang H, Morse H, Ozato K
    Immunity, 2014;40(2):187-98.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  276. Siah2 regulates tight junction integrity and cell polarity through control of ASPP2 stability.
    Authors: Kim H, Claps G, Moller A, Bowtell D, Lu X, Ronai Z
    Oncogene, 2014;33(15):2004-10.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  277. IL-21 induces IL-22 production in CD4+ T cells.
    Authors: Yeste A, Mascanfroni I, Nadeau M, Burns E, Tukpah A, Santiago A, Wu C, Patel B, Kumar D, Quintana F
    Nat Commun, 2014;5(0):3753.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  278. Myostatin stimulates, not inihibits, C2C12 myoblast proliferation.
    Authors: Rodgers B, Wiedeback B, Hoversten K, Jackson M, Walker R, Thompson T
    Endocrinology, 2014;155(3):670-5.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  279. Integrin-mediated type II TGF-beta receptor tyrosine dephosphorylation controls SMAD-dependent profibrotic signaling.
    Authors: Chen X, Wang H, Liao H, Hu W, Gewin L, Mernaugh G, Zhang S, Zhang Z, Vega-Montoto L, Vanacore R, Fassler R, Zent R, Pozzi A
    J Clin Invest, 2014;124(8):3295-310.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  280. Lnk/Sh2b3 controls the production and function of dendritic cells and regulates the induction of IFN-gamma-producing T cells.
    Authors: Mori T, Iwasaki Y, Seki Y, Iseki M, Katayama H, Yamamoto K, Takatsu K, Takaki S
    J Immunol, 2014;193(4):1728-36.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  281. A Snail1/Notch1 signalling axis controls embryonic vascular development.
    Authors: Wu Z, Rowe R, Lim K, Lin Y, Willis A, Tang Y, Li X, Nor J, Maillard I, Weiss S
    Nat Commun, 2014;5(0):3998.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  282. Unexpected phenotype of mice lacking Shcbp1, a protein induced during T cell proliferation.
    Authors: Buckley M, Arandjelovic S, Trampont P, Kim T, Braciale T, Ravichandran K
    PLoS ONE, 2014;9(8):e105576.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  283. Molecular and cellular features of murine craniofacial and trunk neural crest cells as stem cell-like cells.
    Authors: Hagiwara, Kunie, Obayashi, Takeshi, Sakayori, Nobuyuki, Yamanishi, Emiko, Hayashi, Ryuhei, Osumi, Noriko, Nakazawa, Toru, Nishida, Kohji
    PLoS ONE, 2014;9(1):e84072.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  284. Laminin alpha1 regulates age-related mesangial cell proliferation and mesangial matrix accumulation through the TGF-beta pathway.
    Authors: Ning L, Kurihara H, de Vega S, Ichikawa-Tomikawa N, Xu Z, Nonaka R, Kazuno S, Yamada Y, Miner J, Arikawa-Hirasawa E
    Am J Pathol, 2014;184(6):1683-94.
    Species: Mouse
    Sample Types: N/A
    Applications: ELISA Developmet
  285. Hepatocytes induce Foxp3(+) regulatory T cells by Notch signaling.
    Authors: Burghardt S, Claass B, Erhardt A, Karimi K, Tiegs G
    J Leukoc Biol, 2014;96(4):571-7.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  286. Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment.
    Authors: Seth A, Ye J, Yu N, Guez F, Bedford D, Neale G, Cordi S, Brindle P, Lemaigre F, Kaestner K, Sosa-Pineda B
    Development, 2014;141(3):538-47.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  287. Tracking the elusive fibrocyte: identification and characterization of collagen-producing hematopoietic lineage cells during murine wound healing.
    Authors: Suga H, Rennert R, Rodrigues M, Sorkin M, Glotzbach J, Januszyk M, Fujiwara T, Longaker M, Gurtner G
    Stem Cells, 2014;32(5):1347-60.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  288. Matrix metalloproteinase-9 deficiency attenuates diabetic nephropathy by modulation of podocyte functions and dedifferentiation.
    Authors: Li S, Huang P, Yang A, Tarng D, Yang W, Lin C, Chen J, Schmid-Schonbein G, Lin S
    Kidney Int, 2014;86(2):358-69.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  289. Cell-extrinsic CTLA4-mediated regulation of dendritic cell maturation depends on STAT3.
    Authors: Kowalczyk A, D'Souza C, Zhang L
    Eur J Immunol, 2014;44(4):1143-55.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  290. Retinoic acid prevents mesenteric lymph node dendritic cells from inducing IL-13-producing inflammatory Th2 cells.
    Authors: Yokota-Nakatsuma A, Takeuchi H, Ohoka Y, Kato C, Song S, Hoshino T, Yagita H, Ohteki T, Iwata M
    Mucosal Immunol, 2014;7(4):786-801.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  291. Alternative splice variants of AID are not stoichiometrically present at the protein level in chronic lymphocytic leukemia.
    Authors: Rebhandl S, Huemer M, Zaborsky N, Gassner F, Catakovic K, Felder T, Greil R, Geisberger R
    Eur J Immunol, 2014;44(7):2175-87.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  292. Brain glycolipids suppress T helper cells and inhibit autoimmune demyelination.
    Authors: Mycko M, Sliwinska B, Cichalewska M, Cwiklinska H, Raine C, Selmaj K
    J Neurosci, 2014;34(25):8646-58.
  293. Interferon gamma suppresses collagen-induced arthritis by regulation of Th17 through the induction of indoleamine-2,3-deoxygenase.
    Authors: Lee J, Lee J, Park M, Lim M, Park E, Kim E, Yang E, Lee S, Jhun J, Park S, Kim H, Cho M
    PLoS ONE, 2013;8(4):e60900.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  294. Distinctive subdomains in the resorbing surface of osteoclasts.
    Authors: Szewczyk K, Fuller K, Chambers T
    PLoS ONE, 2013;8(3):e60285.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  295. The loss of Trps1 suppresses ureteric bud branching because of the activation of TGF-beta signaling.
    Authors: Gui T, Sun Y, Gai Z, Shimokado A, Muragaki Y, Zhou G
    Dev Biol, 2013;377(2):415-27.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  296. TNF-alpha promotes cerebral pericyte remodeling in vitro, via a switch from alpha1 to alpha2 integrins.
    Authors: Tigges U, Boroujerdi A, Welser-Alves J, Milner R
    J Neuroinflammation, 2013;10(0):33.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  297. Endothelial dysfunction exacerbates renal interstitial fibrosis through enhancing fibroblast Smad3 linker phosphorylation in the mouse obstructed kidney.
    Authors: Sun Y, Qu X, Li X, Nikolic-Paterson D, Li J
    PLoS ONE, 2013;8(12):e84063.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Cell Culture
  298. Control of T helper 2 responses by transcription factor IRF4-dependent dendritic cells.
    Authors: Gao Y, Nish S, Jiang R, Hou L, Licona-Limon P, Weinstein J, Zhao H, Medzhitov R
    Immunity, 2013;39(4):722-32.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  299. Thrombospondin-1 induction in the diabetic myocardium stabilizes the cardiac matrix in addition to promoting vascular rarefaction through angiopoietin-2 upregulation.
    Authors: Gonzalez-Quesada C, Cavalera M, Biernacka A, Kong P, Lee D, Saxena A, Frunza O, Dobaczewski M, Shinde A, Frangogiannis N
    Circ Res, 2013;113(12):1331-44.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  300. Integration of multiple signaling regulates through apoptosis the differential osteogenic potential of neural crest-derived and mesoderm-derived Osteoblasts.
    Authors: Li S, Meyer N, Quarto N, Longaker M
    PLoS ONE, 2013;8(3):e58610.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  301. Exposure to atmospheric particulate matter enhances Th17 polarization through the aryl hydrocarbon receptor.
    Authors: van Voorhis, Michael, Knopp, Samantha, Julliard, Walker, Fechner, John H, Zhang, Xiaoji, Schauer, James J, Mezrich, Joshua D
    PLoS ONE, 2013;8(12):e82545.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  302. FAK-related nonkinase is a multifunctional negative regulator of pulmonary fibrosis.
    Authors: Ding Q, Cai G, Hu M, Yang Y, Zheng A, Tang Q, Gladson C, Hayasaka H, Wu H, You Z, Southern B, Grove L, Rahaman S, Fang H, Olman M
    Am J Pathol, 2013;182(5):1572-84.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  303. Activation of PPAR-alpha induces cell cycle arrest and inhibits transforming growth factor-beta1 induction of smooth muscle cell phenotype in 10T1/2 mesenchymal cells.
    Authors: Lien S, Wei S, Chang S, Chang M, Chang J, Chiu J
    Cell Signal, 2013;25(5):1252-63.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  304. IL-4/IL-13-dependent and independent expression of miR-124 and its contribution to M2 phenotype of monocytic cells in normal conditions and during allergic inflammation.
    Authors: Veremeyko, Tatyana, Siddiqui, Shafiudd, Sotnikov, Ilya, Yung, Amanda, Ponomarev, Eugene D
    PLoS ONE, 2013;8(12):e81774.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  305. Regulation of innate CD8+ T-cell activation mediated by cytokines.
    Proc Natl Acad Sci U S A, 2012;109(25):9971-6.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay

FAQs

  1. Can I reconstitute Recombinant Mouse TGF beta 1 Protein (Catalog # 7666-MB or 7666-MB/CF) in PBS or water?

    • Recombinant Mouse TGF beta 1 Protein (Catalog # 7666-MB or 7666-MB/CF) needs to be reconstituted to 50 μg/mL in sterile 4 mM HCl containing 0.1% BSA, or 4 mM HCl. This protein is hydrophobic by nature, so it requires an acidic buffer for reconstitution to go completely into solution. Stability testing has been evaluated on the protein with these reconstitution conditions; we can guarantee performance under these reconstitution conditions. When the protein is diluted with the cell culture media or buffers to the working concentration, the concentration of the acid should be buffered or negligible.

       

      Recombinant Mouse TGF beta 1 Protein needs to be reconstituted to 50 μg/mL in sterile 4 mM HCl containing 0.1% BSA, or 4 mM HCl.  This protein is hydrophobic by nature, so it requires an acidic buffer for reconstitution to go completely into solution. Stability testing has been evaluated on the protein with these reconstitution conditions; we can guarantee performance under these reconstitution conditions. When the protein is diluted with the cell culture media or buffers to the working concentration, the concentration of the acid should be buffered or negligible.

  2. Is Recombinant Mouse TGF-beta 1 Protein (Catalog # 7666-MB) the latent or mature form?

    • Recombinant Mouse TGF-beta 1 Protein (Catalog # 7666-MB) is composed of Ala279-Ser390, accession # P04202, which corresponds to mature mouse TGFb1.

View all Proteins and Enzyme FAQs

Reviews for Recombinant Mouse TGF-beta 1 Protein

Average Rating: 5 (Based on 14 Reviews)

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Recombinant Mouse TGF-beta 1 Protein
By Anonymous on 11/17/2021
Application: In vitro bioactivity in cell culture

Recombinant Mouse TGF-beta 1 Protein
By Anonymous on 05/04/2021
Application: In vitro bioactivity in cell culture

Recombinant Mouse TGF-beta 1 Protein
By Anonymous on 12/22/2020
Application: In vitro bioactivity in cell culture

Recombinant Mouse TGF-beta 1 Protein
By Anonymous on 12/02/2020
Application: In vitro bioactivity in cell culture

Recombinant Mouse TGF-beta 1 Protein
By Anonymous on 03/13/2020
Application: In vitro bioactivity in cell culture

Recombinant Mouse TGF-beta 1 Protein
By Anonymous on 02/15/2020
Application: Media additive for protein or antibody production

Recombinant Mouse TGF-beta 1 Protein
By Anonymous on 03/28/2019
Application: Binding assay/Protein-protein interaction
Reason for Rating: I used this protein in a competition ELISA to see if the antibodies had similar epitopes.

I coated my plate with 50ng/well of recombinant mouse TGF beta 1 protein (cat# 7666-MB) overnight. I washed and blocked with reagent diluent 2 DY995 for 2hr, washed and added another company's TGFb1 antibody at different concentrations 0.2-100ug/mL in reagent diluent 2 and incubated 1hr. I did not wash my wells but add the two antibodies MAB240-biotinylated it in-house and BAF at a final concentration of 2ug/mL and incubated 1hr diluted in reagent diluent 2. I washed and added streptavidin-HRP DY998 (1:200) and incubated 30 mins, washed and developed with the substrate pack DY999. I found MAB240 competed for binding to the mouse TGF beta 1 protein when the competitor's antibody was present but the chicken polyclonal was not inhibited.


Recombinant Mouse TGF-beta 1 Protein
By jayeeta giri on 01/28/2019
Application: In vitro bioactivity in cell culture

By Anonymous on 06/15/2018
Application: Binding assay/Protein-protein interaction

Recombinant Mouse TGF-beta 1 Protein
By Anonymous on 05/03/2018
Application: In vitro bioactivity in cell culture

Recombinant Mouse TGF-beta 1 Protein
By Anonymous on 04/26/2018
Application: Apoptosis assay

Recombinant Mouse TGF-beta 1 Protein
By Anonymous on 04/22/2018
Application: Apoptosis assay

Recombinant Mouse TGF-beta 1 Protein
By Michelle Chen on 05/10/2017
Application: CellProlif

Recombinant Mouse TGF-beta 1 Protein
By Anonymous on 02/01/2017
Application: In vivo study