Recombinant Mouse TGF-beta 1 Protein

Name: Recombinant Mouse TGF-beta 1 Protein
Brand: R&D Systems
Rating: 5 (2 reviews)

(59 citations)

(2 Reviews)

Purity
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
Endotoxin Level
<0.01 EU per 1 μg of the protein by the LAL method.
Activity
Measured by its ability to inhibit the IL-4-dependent proliferation of HT‑2 mouse T cells. Tsang, M. et al. (1995) Cytokine 7:389. The ED₅₀ for this effect is 0.04-0.2 ng/mL.
Source
Chinese Hamster Ovary cell line, CHO-derived Ala279-Ser390
Accession #

P04202
N-terminal Sequence
Analysis
Ala279
Structure / Form
Disulfide-linked homodimer
Predicted Molecular Mass
12.8 kDa (monomer)
SDS-PAGE
10.5 kDa, reducing conditions

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

7666-MB		7666-MB/CF
Formulation Lyophilized from a 0.2 μm filtered solution in HCl with BSA as a carrier protein.		Formulation Lyophilized from a 0.2 μm filtered solution in HCl.
Reconstitution Reconstitute at 50 μg/mL in 4 mM HCl containing at least 0.1% human or bovine serum albumin.		Reconstitution Reconstitute at 50 μg/mL in 4 mM HCl.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.		Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.		Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: TGF-beta 1

TGF-beta 1 (transforming growth factor beta 1) is one of three closely related mammalian members of the large TGF‑ beta superfamily that share a characteristic cystine knot structure (1‑7). TGF‑ beta 1, -2 and -3 are highly pleiotropic cytokines that are proposed to act as cellular switches that regulate processes such as immune function, proliferation and epithelial‑mesenchymal transition (1‑4). Each TGF‑ beta isoform has some non‑redundant functions; for TGF‑ beta 1, mice with targeted deletion show defects in hematopoiesis and endothelial differentiation, and die of overwhelming inflammation (2). Human or mouse TGF‑ beta 1 cDNA encodes a 390 amino acid (aa) precursor that contains a 29 aa signal peptide and a 361 aa proprotein (8). A furin‑like convertase processes the proprotein to generate an N‑terminal 249 aa latency‑associated peptide (LAP) and a C‑terminal 112 aa mature TGF‑ beta 1 (8, 9). Disulfide‑linked homodimers of LAP and TGF‑ beta 1 remain non‑covalently associated after secretion, forming the small latent TGF‑ beta 1 complex (8‑10). Covalent linkage of LAP to one of three latent TGF‑ beta binding proteins (LTBPs) creates a large latent complex that may interact with the extracellular matrix (9, 10). TGF‑ beta is activated from latency by pathways that include actions of the protease plasmin, matrix metalloproteases, thrombospondin 1 and a subset of integrins (10). Mature mouse TGF‑ beta 1 shares 99‑100% aa sequence identity with human, rat, equine, porcine, canine and bovine TGF‑ beta 1. It demonstrates cross‑species activity (1). TGF‑ beta 1 signaling begins with high‑affinity binding to a type II ser/thr kinase receptor termed TGF‑ beta RII. This receptor then phosphorylates and activates a second ser/thr kinase receptor, TGF‑ beta RI (also called activin receptor‑like kinase (ALK) ‑5), or alternatively, ALK‑1. This complex phosphorylates and activates Smad proteins that regulate transcription (3, 11, 12). Contributions of the accessory receptors betaglycan (also known as TGF‑ beta RIII) and endoglin, or use of Smad‑independent signaling pathways, allow for disparate actions observed in response to TGF‑ beta in different contexts (11).

References:
1. Derynck, R. and K. Miyazono (2008) Cold Spring Harbor Laboratory Press, 29.
2. Dunker, N. and K. Krieglstein (2000) Eur. J. Biochem. 267:6982.
3. Wahl, S.M. (2006) Immunol. Rev. 213:213.
4. Chang, H. et al. (2002) Endocr. Rev. 23:787.
5. Lin, J.S. et al. (2006) Reproduction 132:179.
6. Hinck, A.P. et al. (1996) Biochemistry 35:8517.
7. Mittl, P.R.E. et al. (1996) Protein Sci. 5:1261.
8. Derynck, R. et al. (1985) Nature 316:701.
9. Miyazono, K. et al. (1988) J. Biol. Chem. 263:6407.
10. Oklu, R. and R. Hesketh (2000) Biochem. J. 352:601.
11. de Caestecker, M. et al. (2004) Cytokine Growth Factor Rev. 15:1.
12. Zuniga, J.E. et al. (2005) J. Mol. Biol. 354:1052.
Long Name:
Transforming Growth Factor beta 1
Entrez Gene IDs:
7040 (Human); 21803 (Mouse); 59086 (Rat); 397078 (Porcine); 100033900 (Equine)
Alternate Names:
CEDLAP; DPD1; latency-associated peptide; TGFB; TGFB1; TGF-beta 1 protein; TGFbeta 1; TGF-beta 1; TGFbeta; TGF-beta-1; transforming growth factor beta-1; transforming growth factor, beta 1

Related Research Areas

Citations:

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

59 Citations: Showing 1 - 10
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Species	Applications	Sample Type
Alternative splicing of MALT1 controls signalling and activation of CD4(+) T cells Authors: I Meininger, RA Griesbach, D Hu, T Gehring, T Seeholzer, A Bertossi, J Kranich, A Oeckinghau, AC Eitelhuber, U Greczmiel, A Gewies, M Schmidt-Su, J Ruland, T Brocker, V Heissmeyer, F Heyd, D Krappmann Nat Commun, 2016;7(0):11292. Species: Mouse Sample Type: Whole Cells Application: Bioassay Leptin directly promotes T-cell glycolytic metabolism to drive effector T-cell differentiation in a mouse model of autoimmunity Eur J Immunol, 2016;0(0):. Species: Mouse Sample Type: Whole Cells Application: Bioassay Differential effects of Pax3 on expression of polysialyltransferases STX and PST in TGF-?-treated normal murine mammary gland cells Exp Biol Med (Maywood), 2016;0(0):. Species: Mouse Sample Type: Whole Cells Application: Bioassay Restoration of Corneal Transparency by Mesenchymal Stem Cells Stem Cell Reports, 2016;7(4):583-590. Species: Mouse Sample Type: Whole Cells Application: Bioassay Reduced TCR-dependent activation through citrullination of a T-cell epitope enhances Th17 development by disruption of the STAT3/5 balance Eur J Immunol, 2016;0(0):. Species: Mouse Sample Type: Whole Cells Application: Bioassay Autonomous membrane IgE signaling prevents IgE-memory formation Nat Immunol, 2016;0(0):. Species: Mouse Sample Type: Whole Cells Application: Bioassay Treatment of refractory cutaneous ulcers with mixed sheets consisting of peripheral blood mononuclear cells and fibroblasts Authors: Koji Ueno Sci Rep, 2016;6(0):28538. Species: Mouse Sample Type: Whole Cells Application: Bioassay Affinity for self antigen selects Treg cells with distinct functional properties Nat Immunol, 2016;0(0):. Species: Mouse Sample Type: Whole Cells Application: Bioassay T cells are necessary for ILC2 activation in house dust mite-induced allergic airway inflammation in mice Authors: BW Li, MJ de Bruijn, I Tindemans, M Lukkes, A KleinJan, HC Hoogsteden, RW Hendriks Eur J Immunol, 2016;0(0):. Species: Mouse Sample Type: Whole Cells Application: Bioassay Vimentin coordinates fibroblast proliferation and keratinocyte differentiation in wound healing via TGF-?-Slug signaling Proc Natl Acad Sci USA, 2016;113(30):E4320-7. Species: Mouse Sample Type: Whole Cells Application: Bioassay Pharmacologic modulation of ROR?t translates to efficacy in preclinical and translational models of psoriasis and inflammatory arthritis Sci Rep, 2016;6(0):37977. Species: Mouse Sample Type: Whole Cells Application: Bioassay Th1 cells downregulate connexin 43 gap junctions in astrocytes via microglial activation Sci Rep, 2016;6(0):38387. Species: Mouse Sample Type: Whole Cells Application: Bioassay Beta 1-integrin ligation and TLR ligation enhance GM-CSF-induced ALDH1A2 expression in dendritic cells, but differentially regulate their anti-inflammatory properties Sci Rep, 2016;6(0):37914. Species: Mouse Sample Type: Whole Cells Application: Bioassay All Trans Retinoic Acid, Transforming Growth Factor ? and Prostaglandin E2 in Mouse Plasma Synergize with Basophil-Secreted Interleukin-4 to M2 Polarize Murine Macrophages PLoS ONE, 2016;11(12):e0168072. Species: Mouse Sample Type: Whole Cells Application: Bioassay miR-148a is upregulated by Twist1 and T-bet and promotes Th1-cell survival by regulating the proapoptotic gene Bim. Authors: Haftmann C, Stittrich A, Zimmermann J, Fang Z, Hradilkova K, Bardua M, Westendorf K, Heinz G, Riedel R, Siede J, Lehmann K, Weinberger E, Zimmel D, Lauer U, Haupl T, Sieper J, Backhaus M, Neumann C, Hoffmann U, Porstner M, Chen W, Grun J, Baumgrass R, Matz M, Lohning M, Scheffold A, Wittmann J, Chang H, Rajewsky N, Jack H, Radbruch A, Mashreghi M Eur J Immunol, 2015;45(4):1192-205. Species: Mouse Sample Type: Cell Culture Treatment Application: Bioassay Mesenchymal stem/stromal cells protect against autoimmunity via CCL2-dependent recruitment of myeloid-derived suppressor cells. Authors: Lee H, Ko J, Jeong H, Ko A, Kim M, Wee W, Yoon S, Oh J J Immunol, 2015;194(8):3634-45. Species: Mouse Sample Type: Whole Cells Application: Bioassay Testosterone suppresses hepatic inflammation by the downregulation of IL-17, CXCL-9, and CXCL-10 in a mouse model of experimental acute cholangitis. Authors: Schwinge D, Carambia A, Quaas A, Krech T, Wegscheid C, Tiegs G, Prinz I, Lohse A, Herkel J, Schramm C J Immunol, 2015;194(6):2522-30. Species: Mouse Sample Type: Whole Cells Application: Bioassay Retinoic acid can exacerbate T cell intrinsic TLR2 activation to promote tolerance. Authors: Nguyen, Vivien, Pearson, Kandyce, Kim, Jee-Hyun, Kamdar, Karishma, DePaolo, R Willia PLoS ONE, 2015;10(3):e0118875. Species: Mouse Sample Type: Whole Cells Application: Bioassay Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros-derived hematopoietic stem cells. Authors: Hadland B, Varnum-Finney B, Poulos M, Moon R, Butler J, Rafii S, Bernstein I J Clin Invest, 2015;125(5):2032-45. Species: Mouse Sample Type: protein Application: Bioassay Blocking follistatin-like 1 attenuates bleomycin-induced pulmonary fibrosis in mice. Authors: Dong Y, Geng Y, Li L, Li X, Yan X, Fang Y, Li X, Dong S, Liu X, Li X, Yang X, Zheng X, Xie T, Liang J, Dai H, Liu X, Yin Z, Noble P, Jiang D, Ning W J Exp Med, 2015;212(2):235-52. Species: Mouse Sample Type: Whole Cells Application: Bioassay Long non-coding RNAs (LncRNA) regulated by transforming growth factor (TGF) beta: LncRNA-hit-mediated TGFbeta-induced epithelial to mesenchymal transition in mammary epithelia. Authors: Richards E, Zhang G, Li Z, Permuth-Wey J, Challa S, Li Y, Kong W, Dan S, Bui M, Coppola D, Mao W, Sellers T, Cheng J J Biol Chem, 2015;290(11):6857-67. Species: Mouse Sample Type: Whole Cells Application: Bioassay Monocyte Chemoattractant Protein-Induced Protein 1 (MCPIP1) Enhances Angiogenic and Cardiomyogenic Potential of Murine Bone Marrow-Derived Mesenchymal Stem Cells. Authors: Labedz-Maslowska A, Lipert B, Berdecka D, Kedracka-Krok S, Jankowska U, Kamycka E, Sekula M, Madeja Z, Dawn B, Jura J, Zuba-Surma E PLoS ONE, 2015;10(7):e0133746. Species: Mouse Sample Type: Whole Cells Application: Bioassay Impaired dendritic cell function in a spontaneous autoimmune polyneuropathy. Authors: Quan S, Kim H, Dukala D, Sheng J, Soliven B J Immunol, 2015;194(9):4175-84. Species: Mouse Sample Type: Whole Cells Application: Bioassay ShcA regulates late stages of T cell development and peripheral CD4+ T cell numbers. Authors: Buckley M, Trampont P, Arandjelovic S, Fond A, Juncadella I, Ravichandran K J Immunol, 2015;194(4):1665-76. Species: Mouse Sample Type: Whole Cells Application: Bioassay Novel mechanism of macrophage-mediated metastasis revealed in a zebrafish model of tumor development. Authors: Wang J, Cao Z, Zhang X, Nakamura M, Sun M, Hartman J, Harris R, Sun Y, Cao Y Cancer Res, 2015;75(2):306-15. Species: Mouse Sample Type: Whole Cells Application: Bioassay A functional polymorphism of Ptpn22 is associated with type 1 diabetes in the BioBreeding rat. Authors: Sarmiento J, Wallis R, Ning T, Marandi L, Chao G, Veillette A, Lernmark A, Paterson A, Poussier P J Immunol, 2015;194(2):615-29. Species: Rat Sample Type: Whole Cells Application: Bioassay Beclin 1 regulates neuronal transforming growth factor-beta signaling by mediating recycling of the type I receptor ALK5. Authors: O'Brien C, Bonanno L, Zhang H, Wyss-Coray T Mol Neurodegener, 2015;10(1):69. Species: Mouse Sample Type: Whole Cells Application: Bioassay Itk signals promote neuroinflammation by regulating CD4+ T-cell activation and trafficking. Authors: Kannan A, Kim D, August A, Bynoe M J Neurosci, 2015;35(1):221-33. Species: Mouse Sample Type: Whole Cells Application: Bioassay IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iTreg cell balance. Authors: Basu R, Whitley S, Bhaumik S, Zindl C, Schoeb T, Benveniste E, Pear W, Hatton R, Weaver C Nat Immunol, 2015;16(3):286-95. Species: Mouse Sample Type: Whole Cells Application: Bioassay Myocardin-related transcription factors control the motility of epicardium-derived cells and the maturation of coronary vessels. Authors: Trembley M, Velasquez L, de Mesy Bentley K, Small E Development, 2015;142(1):21-30. Dendritic cell SIRT1-HIF1alpha axis programs the differentiation of CD4+ T cells through IL-12 and TGF-beta1. Authors: Liu G, Bi Y, Xue L, Zhang Y, Yang H, Chen X, Lu Y, Zhang Z, Liu H, Wang X, Wang R, Chu Y, Yang R Proc Natl Acad Sci U S A, 2015;112(9):E957-65. Species: Mouse Sample Type: Whole Cells Application: Bioassay Regulatory T cell reprogramming toward a Th2-cell-like lineage impairs oral tolerance and promotes food allergy. Authors: Noval Rivas M, Burton O, Wise P, Charbonnier L, Georgiev P, Oettgen H, Rachid R, Chatila T Immunity, 2015;42(3):512-23. Species: Mouse Sample Type: Whole Cells Application: Bioassay TGF-beta and opioid receptor signaling crosstalk results in improvement of endogenous and exogenous opioid analgesia under pathological pain conditions. Authors: Lantero A, Tramullas M, Pilar-Cuellar F, Valdizan E, Santillan R, Roques B, Hurle M J Neurosci, 2014;34(15):5385-95. Species: Mouse Sample Type: In Vivo Application: In Vivo Blockade of IL-33 release and suppression of type 2 innate lymphoid cell responses by helminth secreted products in airway allergy. Authors: McSorley H, Blair N, Smith K, McKenzie A, Maizels R Mucosal Immunol, 2014;7(5):1068-78. Species: Mouse Sample Type: In Vivo Application: In Vivo Hepatocytes induce Foxp3(+) regulatory T cells by Notch signaling. Authors: Burghardt S, Claass B, Erhardt A, Karimi K, Tiegs G J Leukoc Biol, 2014;96(4):571-7. Species: Mouse Sample Type: Whole Cells Application: Bioassay Brain glycolipids suppress T helper cells and inhibit autoimmune demyelination. Authors: Mycko M, Sliwinska B, Cichalewska M, Cwiklinska H, Raine C, Selmaj K J Neurosci, 2014;34(25):8646-58. Real-time imaging of the epithelial-mesenchymal transition using microRNA-200a sequence-based molecular beacon-conjugated magnetic nanoparticles. Authors: Choi Y, Kim H, Woo J, Hwang E, Cho K, Kim S, Moon W PLoS ONE, 2014;9(7):e102164. Species: Canine Sample Type: Whole Cells Application: Bioassay A Snail1/Notch1 signalling axis controls embryonic vascular development. Authors: Wu Z, Rowe R, Lim K, Lin Y, Willis A, Tang Y, Li X, Nor J, Maillard I, Weiss S Nat Commun, 2014;5(0):3998. Species: Mouse Sample Type: Whole Cells Application: Bioassay Tracking the elusive fibrocyte: identification and characterization of collagen-producing hematopoietic lineage cells during murine wound healing. Authors: Suga H, Rennert R, Rodrigues M, Sorkin M, Glotzbach J, Januszyk M, Fujiwara T, Longaker M, Gurtner G Stem Cells, 2014;32(5):1347-60. Species: Mouse Sample Type: Whole Cells Application: Bioassay HIV Nef expression favors the relative preservation of CD4+ T regulatory cells that retain some important suppressive functions. Authors: Chrobak P, Afkhami S, Priceputu E, Poudrier J, Meunier C, Hanna Z, Sparwasser T, Jolicoeur P J Immunol, 2014;192(4):1681-92. Species: Mouse Sample Type: Whole Cells Application: Bioassay Siah2 regulates tight junction integrity and cell polarity through control of ASPP2 stability. Authors: Kim H, Claps G, Moller A, Bowtell D, Lu X, Ronai Z Oncogene, 2014;33(15):2004-10. Species: Mouse Sample Type: Whole Cells Application: Bioassay Integrin-mediated type II TGF-beta receptor tyrosine dephosphorylation controls SMAD-dependent profibrotic signaling. Authors: Chen X, Wang H, Liao H, Hu W, Gewin L, Mernaugh G, Zhang S, Zhang Z, Vega-Montoto L, Vanacore R, Fassler R, Zent R, Pozzi A J Clin Invest, 2014;124(8):3295-310. Species: Mouse Sample Type: Whole Cells Application: Bioassay Myostatin stimulates, not inihibits, C2C12 myoblast proliferation. Authors: Rodgers B, Wiedeback B, Hoversten K, Jackson M, Walker R, Thompson T Endocrinology, 2014;155(3):670-5. Species: Mouse Sample Type: whole cells Application: Bioassay Laminin alpha1 regulates age-related mesangial cell proliferation and mesangial matrix accumulation through the TGF-beta pathway. Authors: Ning L, Kurihara H, de Vega S, Ichikawa-Tomikawa N, Xu Z, Nonaka R, Kazuno S, Yamada Y, Miner J, Arikawa-Hirasawa E Am J Pathol, 2014;184(6):1683-94. Species: Mouse Sample Type: N/A Application: ELISA development Retinoic acid prevents mesenteric lymph node dendritic cells from inducing IL-13-producing inflammatory Th2 cells. Authors: Yokota-Nakatsuma A, Takeuchi H, Ohoka Y, Kato C, Song S, Hoshino T, Yagita H, Ohteki T, Iwata M Mucosal Immunol, 2014;7(4):786-801. Species: Mouse Sample Type: Whole Cells Application: Bioassay Cell-extrinsic CTLA4-mediated regulation of dendritic cell maturation depends on STAT3. Authors: Kowalczyk A, D'Souza C, Zhang L Eur J Immunol, 2014;44(4):1143-55. Species: Mouse Sample Type: Whole Cells Application: Bioassay Attenuation of experimental colitis in glutathione peroxidase 1 and catalase double knockout mice through enhancing regulatory T cell function. Authors: Kim H, Lee A, Choi E, Kie J, Lim W, Lee H, Moon B, Seoh J PLoS ONE, 2014;9(4):e95332. Species: Mouse Sample Type: Whole Cells Application: Bioassay IL-21 induces IL-22 production in CD4+ T cells. Authors: Yeste A, Mascanfroni I, Nadeau M, Burns E, Tukpah A, Santiago A, Wu C, Patel B, Kumar D, Quintana F Nat Commun, 2014;5(0):3753. Species: Mouse Sample Type: Whole Cells Application: Bioassay Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment. Authors: Seth A, Ye J, Yu N, Guez F, Bedford D, Neale G, Cordi S, Brindle P, Lemaigre F, Kaestner K, Sosa-Pineda B Development, 2014;141(3):538-47. Species: Mouse Sample Type: Whole Tissue Application: Bioassay IL-4/IL-13-dependent and independent expression of miR-124 and its contribution to M2 phenotype of monocytic cells in normal conditions and during allergic inflammation. Authors: Veremeyko, Tatyana, Siddiqui, Shafiudd, Sotnikov, Ilya, Yung, Amanda, Ponomarev, Eugene D PLoS ONE, 2013;8(12):e81774. Species: Mouse Sample Type: Whole Cells Application: Bioassay Endothelial dysfunction exacerbates renal interstitial fibrosis through enhancing fibroblast Smad3 linker phosphorylation in the mouse obstructed kidney. Authors: Sun Y, Qu X, Li X, Nikolic-Paterson D, Li J PLoS ONE, 2013;8(12):e84063. Species: Rat Sample Type: whole cells Application: cell culture Activation of PPAR-alpha induces cell cycle arrest and inhibits transforming growth factor-beta1 induction of smooth muscle cell phenotype in 10T1/2 mesenchymal cells. Authors: Lien S, Wei S, Chang S, Chang M, Chang J, Chiu J Cell Signal, 2013;25(5):1252-63. Species: Mouse Sample Type: Whole Cells Application: Bioassay Integration of multiple signaling regulates through apoptosis the differential osteogenic potential of neural crest-derived and mesoderm-derived Osteoblasts. Authors: Li S, Meyer N, Quarto N, Longaker M PLoS ONE, 2013;8(3):e58610. Species: Mouse Sample Type: Whole Cells Application: Bioassay TNF-alpha promotes cerebral pericyte remodeling in vitro, via a switch from alpha1 to alpha2 integrins. Authors: Tigges U, Boroujerdi A, Welser-Alves J, Milner R J Neuroinflammation, 2013;10(0):33. Species: Mouse Sample Type: Whole Cells Application: Bioassay Exposure to atmospheric particulate matter enhances Th17 polarization through the aryl hydrocarbon receptor. Authors: van Voorhis, Michael, Knopp, Samantha, Julliard, Walker, Fechner, John H, Zhang, Xiaoji, Schauer, James J, Mezrich, Joshua D PLoS ONE, 2013;8(12):e82545. Species: Mouse Sample Type: whole cells Application: cell culture FAK-related nonkinase is a multifunctional negative regulator of pulmonary fibrosis. Authors: Ding Q, Cai G, Hu M, Yang Y, Zheng A, Tang Q, Gladson C, Hayasaka H, Wu H, You Z, Southern B, Grove L, Rahaman S, Fang H, Olman M Am J Pathol, 2013;182(5):1572-84. Species: Mouse Sample Type: Whole Cells Application: Bioassay Thrombospondin-1 induction in the diabetic myocardium stabilizes the cardiac matrix in addition to promoting vascular rarefaction through angiopoietin-2 upregulation. Authors: Gonzalez-Quesada C, Cavalera M, Biernacka A, Kong P, Lee D, Saxena A, Frunza O, Dobaczewski M, Shinde A, Frangogiannis N Circ Res, 2013;113(12):1331-44. Species: Mouse Sample Type: Whole Cells Application: Bioassay The loss of Trps1 suppresses ureteric bud branching because of the activation of TGF-beta signaling. Authors: Gui T, Sun Y, Gai Z, Shimokado A, Muragaki Y, Zhou G Dev Biol, 2013;377(2):415-27. Species: Mouse Sample Type: Whole Tissue Application: Bioassay Regulation of innate CD8+ T-cell activation mediated by cytokines. Proc Natl Acad Sci U S A, 2012;109(25):9971-6. Species: Mouse Sample Type: Whole Cells Application: Bioassay Expand to show all 59 Citations

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Size	Price	Qty	Stk
7666-MB-005/CF 5 ug	$355
7666-MB-005 5 ug	$355

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