E3 Ligases

Find Your E3 Ligases and Related Products

Single-subunit E3 Ligases

These single subunit E3 ligases are capable of ubiquitinating protein substrates in vitro when supplied with ubiquitin, E1, an appropriate E2, and ATP. These include enzymes from the RING, U-box, HECT and RBR class E3’s.

Multi-subunit E3 Ligase Complexes

Many E3 ligases are assembled from multiple subunits, in many cases consisting of a substrate receptor, an adaptor(s), a cullin and a RING. These include enzymes from Skp-Cul1-Fbox, Elongin-Cul2/5-SOCS box, DCAF-Cul4 and others E3 classes. Some products are capable of ubiquitinating protein substrates in vitro when supplied with ubiquitin, E1, an appropriate E2, and ATP. Others are purified substrate receptors for use in binding studies.

Accessory Proteins

Accessory proteins include E3 ligase co-factors such as kinases and heat shock proteins. Also included are E3 ligase substrates and proteins for research in aggresomal disorders.

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Other Resources

Ubiquitin and Ubiquitin-like Modifiers

Protocol: Determine Ubiquitin Chain Linkage

In Vitro Ubiquitin Conjugation Protocols

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