17 results for "CRBN" in Products

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CRBN Products

Modulates cell surface expression of KCNT1 . May be involved in memory and learning

ZNL 02-096

Catalog #: 7240
Citations (2)
Product Documents

Potent and selective Wee1 Degrader (PROTAC®)

Chemical Name: 4-((3-(4-(4-((2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)phenyl)piperazin-1-yl)propyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
Purity: ≥98%
Potent and selective Wee1 Degrader (PROTAC®)

CRBN-6-5-5-VHL

Catalog #: 6948
Product Documents

Potent and selective cereblon Degrader (PROTAC®); cell-permeable

Chemical Name: (2S,4R)-1-((2S)-2-(5-((5-((6-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hexyl)oxy)pentyl)oxy)pentanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity: ≥96%
Application of CRBN-6-5-5-VHL in MM1S cells for CRBN-6-5-5-VHL
(2)

CRBN PROTAC® 14a

Catalog #: 7219
Product Documents

Cereblon Degrader (PROTAC®)

Chemical Name: N1-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)-N20-((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)-3,9,12,18-tetraoxaicosanediamide
Purity: ≥98%
Cereblon Degrader (PROTAC®)

JH-XI-10-02

Catalog #: 7304
Product Documents

CDK8 Degrader (PROTAC®)

Chemical Name: 15-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-N-[(3β,5α,17β)-17-(7-isoquinolinyl)androstan-3-yl]-N-methyl-4,7,10,13-tetraoxapentadecanamide
Purity: ≥98%
CDK8 Degrader (PROTAC®)

FC 11

Catalog #: 7306
Citations (2)
Product Documents

Highly potent focal adhesion kinase (FAK) Degrader (PROTAC®)

Chemical Name: 1-[2-[2-[2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]-N-[4-[[4-[[[2-[methyl(methylsulfonyl)amino]-3-pyridinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]phenyl]-1H-1,2,3-triazole-4-carboxamide
Purity: ≥98%
Highly potent focal adhesion kinase (FAK) Degrader (PROTAC®)

MS 154

Catalog #: 7395
Product Documents

Potent and selective cereblon-recruiting Degrader (PROTAC®) of mutant EGFR

Chemical Name: 3-(4-(3-((4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperazin-1-yl)-N-(8-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)octyl)propanamide
Purity: ≥98%
Potent and selective cereblon-recruiting Degrader (PROTAC®) of mutant EGFR

CG 858

Catalog #: 7427
Product Documents

Selective BRAF-V600E protein Degrader (uSMITE™)

Chemical Name: N-[[4-[3-[2,6-Difluoro-3-[(propylsulfonyl)amino]benzoyl]-1H-pyrrolo[2,3-b]pyridin-5-yl]phenyl]methyl]-5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]amino]pentanamide
Purity: ≥98%
Selective BRAF-V600E protein Degrader (uSMITE™)

PT-65

Catalog #: 7651
Citations (1)
Product Documents

Potent GSK3 Degrader (PROTAC®)

Chemical Name: 3-Amino-6-(4-((4-(4-(1-(17-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12,15-pentaoxaheptadecyl)-1H-1,2,3-triazol-4-yl)butyl)piperazin-1-yl)sulfonyl)phenyl)-N-(pyridin-3-yl)pyrazine-2-carboxamide
Purity: ≥98%
Potent GSK3 Degrader (PROTAC®)

HHP 9

Catalog #: 7828
Product Documents

BET bromodomain Degrader (PROTAC®); also potent Hedgehog pathway inhibitor

Chemical Name: 2-Methoxyethyl 4-(3-((1-(6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)hexyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate
Purity: ≥98%
BET bromodomain Degrader; also potent Hedgehog pathway inhibitor

JB 300

Catalog #: 7837
Product Documents

Aurora A Degrader (PROTAC®)

Chemical Name: trans-4-(3-Chloro-2-fluorophenoxy)-N-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)ethoxy)ethoxy)ethyl)-1-((6-(thiazol-2-ylamino)pyridin-2-yl)methyl)cyclohexane-1-carboxamide
Purity: ≥98%
Aurora A Degrader (PROTAC®)

PROTAC®(H-PGDS)-7

Catalog #: 8004
Product Documents

Potent hematopoietic prostaglandin D2 synthase Degrader (PROTAC®)

Chemical Name: N-[4-[4-[[4-[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-1-piperazinyl]carbonyl]-1-piperidinyl]phenyl]-2-phenoxy-5-pyrimidinecarboxamide
Purity: ≥98%
Potent hematopoietic prostaglandin D2 synthase Degrader (PROTAC®)

α-Synuclein Degrader 2b

Catalog #: 8040
Citations (1)
Product Documents

α-synuclein Degrader (PROTAC®)

Chemical Name: 2-[[3-[5-(1,3-Benzodioxol-5-yl)-1H-pyrazol-3-yl]phenyl]amino]-N-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethyl]acetamide
Purity: ≥98%
α-synuclein PROTAC® Degrader

STING Degrader SP23

Catalog #: 8053
Product Documents

Selective STING Degrader (PROTAC®)

Chemical Name: (2E)-N1-[6-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]hexyl]-N4-[4-[[(5-nitro-2-furanyl)carbonyl]amino]phenyl]-2-butenediamide
Purity: ≥98%
Selective STING Degrader (PROTAC®)

JQ dS-4

Catalog #: 8152
Product Documents

BRG1/SMARCA4 Degrader (PROTAC®)

Chemical Name: 3-((4-(3-(2-Chloropyridin-4-yl)ureido)pyridin-2-yl)ethynyl)-N-(4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)butyl)benzamide
Purity: ≥95%
BRG1/SMARCA4 Degrader (PROTAC®)

AZ 3137

Catalog #: 8833
Product Documents

Potent and selective AR and AR L702H Degrader, orally bioavailable

Chemical Name: 4-[4-[4-[4-[[4-[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-7-methoxy-1-oxo-1H-isoindol-5-yl]-1-piperazinyl]methyl]-1-piperidinyl]phenyl]-1-piperidinyl]-3-fluoro-2-(trifluoromethyl)benzonitrile
Purity: ≥98%
Potent and selective AR and AR L702H Degrader, orally bioavailable

NX 5948

Catalog #: 8856
Product Documents

Potent and selective BTK Degrader (PROTAC®)

Chemical Name: 3-[[4-[1-[[1-[6-[[[(3S)-2,6-Dioxo-3-piperidinyl]amino]carbonyl]-3-pyridinyl]-4-piperidinyl]methyl]-4-piperidinyl]phenyl]amino]-5-[(3R)-3-(3-methyl-2-oxo-1-imidazolidinyl)-1-piperidinyl]-2-pyrazinecarboxamide
Purity: ≥98%
Selective BTK Degrader

NX 2127

Catalog #: 8951
Product Documents

Potent BTK Degrader (PROTAC®)

Chemical Name: 3-[[4-[1-[[(3R)-1-[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-3-pyrrolidinyl]methyl]-4-piperidinyl]phenyl]amino]-5-(1-piperidinyl)-2-pyrazinecarboxamide
Purity: ≥98%
Potent BTK Degrader (PROTAC®)
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