103 results for "Jak1" in Products
Jak1 Products
Jak1, Jak 2, and Jak3 belong to the Janus Kinases family of protein tyrosine kinases that couple to cytokine receptors once activated by their corresponding ligands. Activation of Jak family members occurs via phosphorylation at two adjacent tyrosine residues as well as potentially one or more serine residues. Jaks activate members of the STAT family of transcription factors by phosphorylating critical tyrosine regulatory sites.
Jak1 is required for the activation of STAT1 and STAT2 in ...
| Reactivity: | Human, Mouse, Rat |
| Details: | Rat IgG2B Monoclonal Clone #413104 |
| Applications: | WB, Simple Western |
| Reactivity: | Human, Mouse |
| Details: | Mouse IgG2A Monoclonal Clone #452804 |
| Applications: | WB, Simple Western |
Potent JAK inhibitor
| Alternate Names: | Tofacitinib citrate |
| Chemical Name: | (3R,4R)-4-Methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-β-oxo-1-piperidinepropanenitrile citrate |
| Purity: | ≥98% |
Recombinant Monoclonal Antibody
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #JM75-03 |
| Applications: | IHC, WB, Flow |
![Western Blot: Jak1 Antibody (JM75-03) [NBP2-75547]](https://resources.rndsystems.com/images/products/Jak1-Antibody-JM75-03-Western-Blot-NBP2-75547-img0005.jpg "Western Blot: Jak1 Antibody (JM75-03) [NBP2-75547]")
| Reactivity: | Mouse, Rat |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, ICC/IF |
Potent and selective JAK1/JAK2 inhibitor; orally bioavailable
| Alternate Names: | INCB018424 |
| Chemical Name: | (3R)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile |
| Purity: | ≥98% |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB |
![Jak1 [p Tyr1022] Antibody](https://resources.rndsystems.com/images/products/nb100-82005_rabbit-polyclonal-jak1-p-tyr1022-antibody-113202594526.jpg "Immunohistochemistry-Paraffin: Jak1 [p Tyr1022] Antibody [NB100-82005] -")
| Reactivity: | Human |
| Source: | HEK293 |
| Accession #: | P23458.2 |
| Applications: | Bioactivity |
Highly potent JAK1 and JAK2 inhibitor; also inhibits JAK3 and Tyk2
| Alternate Names: | INCB 28050 |
| Chemical Name: | 1-(Ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-azetidineacetonitrile |
| Purity: | ≥98% |
JAK1-selective inhibitor
| Chemical Name: | (3S,4R)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-1-pyrrolidinecarboxamide |
| Purity: | ≥98% |
Potent pan-JAK inhibitor; induces intermediate mesoderm; cell-permeable
| Alternate Names: | JAK inhibitor I |
| Chemical Name: | 2-(1,1-Dimethylethyl)-9-fluoro-1,6-dihydro-7H-benz[h]imidazo[4,5-f]isoquinolin-7-one |
| Purity: | ≥98% |
Phosphate salt of Ruxolitinib (Cat. No. 7064); potent and selective JAK1/JAK2 inhibitor
| Chemical Name: | (3R)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile phosphate |
| Purity: | ≥98% |
| Reactivity: | Human |
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ICC/IF |
| Reactivity: | Human |
| Source: | Wheat germ |
| Applications: | WB, ELISA, AP, MA |
| Reactivity: | Human |
| Sensitivity: | 0.094 ng/mL |
| Assay Range: | 0.156-10 ng/mL |
| Applications: | ELISA |
| Reactivity: | Mouse, Rat |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, ICC/IF |
| Reactivity: | Mouse, Rat |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, ICC/IF |
| Reactivity: | Mouse, Rat |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, ICC/IF |
| Reactivity: | Mouse, Rat |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, ICC/IF |
| Reactivity: | Mouse, Rat |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, ICC/IF |
| Reactivity: | Mouse, Rat |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, ICC/IF |
| Reactivity: | Mouse, Rat |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, ICC/IF |
| Reactivity: | Mouse, Rat |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, ICC/IF |
| Reactivity: | Human, Mouse |
| Details: | Mouse IgG2A Monoclonal Clone #452804 |
| Applications: | WB |