p38 alpha: Products

The p38 Mitogen-activated Protein Kinases (MAPKs) are a family of four related Ser/Thr kinases activated by proinflammatory cytokines and environmental stresses.

The most frequently analyzed family member, p38 alpha, also known as SAPK2a and MAPK14, was initially purified as a kinase critical to the signaling cascade linking IL-1 to MAPKAPK-2 and the small heat shock protein HSP27. Ubiquitously expressed, p38 alpha is dually phosphorylated by MKK3 and MKK6 at Thr180 and Tyr182. Once activated, p38 alpha phosphorylates a number of targets, including the cytoplasmic kinases MNK 4 and PRAK5 and the nuclear transcription factors ATF2 1 and STAT1. Several promising compounds that inhibit p38 alpha are being investigated as potential therapies for arthritic and inflammatory diseases.

"p38 alpha" has 23 results in Products.
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Proteome Profiler Human Phospho-Kinase Array Kit

Contains 4 sets of 2 membranes - each spotted in duplicate with antibodies against 43 different kinases and 2 related total proteins

Human/Mouse/Rat p38 alpha Antibody

5 Images
IHC, KO, Simple Western, WB

Proteome Profiler Human Phospho-MAPK Array Kit

Contains 4 membranes - each spotted in duplicate with 26 different MAPK antibodies

CMPD-1

Selective inhibitor of p38α-mediated MK2a phosphorylation; also tubulin polymerization inhibitor

JX 401

Potent, reversible p38α inhibitor

EO 1428

Selective inhibitor of p38α and p38β2

RWJ 67657

Potent, selective p38α and p38β inhibitor

VX 745

Potent and selective p38α inhibitor

VX 702

Orally active p38α and p38β inhibitor

AMG 548

Potent and selective p38α inhibitor

ML 3403

p38 inhibitor

AL 8697

Potent and selective p38α inhibitor

AZ 12080282 dihydrochloride

Inhibitor of Hedgehog (Hh) signaling

SB 706504

p38 MAPK inhibitor

DBM 1285 dihydrochloride

p38 MAPK inhibitor; anti-inflammatory

PH 797804

Potent and selective p38α/β inhibitor

Org 48762-0

Selective p38α/β inhibitor; orally bioavailable
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