Proteome Profiler Human Phospho-Kinase Array Kit

Contains 4 sets of 2 membranes - each spotted in duplicate with antibodies against 37 different kinases and 2 related total proteins
Catalog # Availability Size / Price Qty
ARY003C

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Detection of human protein kinase phosphorylation in A549 Cell Line.
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Proteome Profiler Human Phospho-Kinase Array Kit Summary

Kit Summary

A membrane-based antibody array for the parallel determination of the relative levels of human protein kinase phosphorylation. Validated for analyte detection in cell lysates.

Troubleshooting Guide

Key Benefits

  • Detects phosphorylation of 37 human kinases and total amounts of 2 related proteins simultaneously
  • Requires no specialized equipment

 

Principle of the Assay

The Proteome Profiler Human Phospho-Kinase Array Kit is a membrane-based sandwich immunoassay. Capture antibodies spotted in duplicate on nitrocellulose membranes bind to specific target proteins present in the sample (Step 1). Captured proteins are detected with biotinylated detection antibodies (Step 2) and then visualized using chemiluminescent detection reagents (Step 3). The signal produced is proportional to the amount phosphorylation in the bound analyte.

Why Use an Antibody Array to Detect Receptor Phosphorylation?

Determining the phosphorylation of multiple kinases in a single sample can be expensive, time consuming and can require specialized equipment. Performing multiple immunoprecipitations and Western blots requires time, labor, and reagents. The use of a multiplex antibody array to detect multiple phosphorylations in a single sample can be cost-effective and also save time and sample.

 

 

Kit Contents

Each Human Phospho-Kinase Antibody Array Kit contains most of the necessary components for a ready-to-run assay without the need for specialized equipment.

  • 8 Array Membranes (4 of membrane A and 4 of membrane B)
  • 8-Well Multi-dish
  • Lysis Buffer
  • Array Buffers
  • Wash Buffer
  • Detection Antibody Cocktail A
  • Detection Antibody Cocktail B
  • Streptavidin-HRP
  • Chemiluminescent Detection Reagents
  • Transparency Overlay Template
  • Detailed product datasheet with protocol

For a complete list of the kit contents and necessary materials, please see the Materials Provided/Other Supplies Required sections of the product datasheet.

Stability and Storage

Store the unopened kit at 2°C to 8°C. Do not use past kit expiration date.

 
Simultaneously detect the relative phosphorylation of these proteins in a single sample.
Akt 1/2/3 (S473) HSP60 PRAS40 (T246)
Akt 1/2/3 (T308) JNK 1/2/3 (T183/Y185, T221/Y223) Pyk2 (Y402)
beta-Catenin Lck (Y394) RSK1/2 (S221/S227)
Chk-2 (T68) Lyn (Y397) RSK1/2/3 (S380/S386/S377)
c-Jun (S63) MSK1/2 (S376/S360) Src (Y419)
CREB (S133) p38 alpha (T180/Y182) STAT1 (Y701)
EGF R (Y1086) p53 (S15) STAT2 (Y689)
eNOS (S1177) p53 (S392) STAT3 (S727)
ERK1/2 (T202/Y204, T185/Y187) p53 (S46) STAT3 (Y705)
Fgr (Y412) P70 S6 Kinase (T389) STAT5a/b (Y699)
GSK-3 alpha/beta (S21/S9) p70 S6 Kinase (T421/S424) STAT6 (Y641)
GSK-3 beta (S9) PDGF R beta (Y751) WNK-1 (T60)
HSP27 (S78/S82) PLC gamma-1 (Y783) Yes (Y426)

 

Assays for analytes represented in the Human Phospho-Kinase Array Kit

 

Analyte DuoSet® IC ELISA Development Systems (Total) DuoSet® IC ELISA
Development Systems (Phospho)
Quantikine®
ELISA Kits
Akt (S473)   DYC887B  
Akt (T308)      
beta-Catenin DYC1329    
Chk2 (T68)   DYC1626  
c-Jun (S63)      
CREB (S133)   DYC2510  
EGF R (Y1086) DYC1854   DEGFR0
eNOS (S1177)      
ERK1/2 (T202/Y204, T185/Y187)   DYC1018B  
Fgr (Y412)      
GSK-1 beta (S9)      
GSK-3 alpha/beta (S21/S9) DYC2157 DYC2630  
HSP27 (S78/S82) DYC1580 DYC2314  
HSP60 DYC1800    
JNK pan (T183/Y185, T221/Y223) DYC1205 DYC1387  
Lck (Y394)      
Lyn (Y397)   DYC3936  
MSK1/2 (S376/S360)      
p38 alpha (T180/Y182) DYC8691B DYC869B  
p53 (S15) DYC1043 DYC1839  
p53 (S46) DYC1043 DYC1489  
p53 (S392) DYC1043 DYC2996  
p70 S6 Kinase (T389)   DYC896  
p70 S6 Kinase (T421/S424) DYC8962 DYC8965  
PDGF R beta (Y751) DYC385 DYC3096  
PLC gamma-1 (Y783)      
PRAS40 (T246)   DYC6890  
PYK2 (Y402)      
RSK1/2 (S221/S227)      
RSK1/2/3 (S380/S386/S377)   DYC889B  
Src (Y419)   DYC2685  
STAT1 (Y701)      
STAT2 (Y689)      
STAT3 (S727)      
STAT3 (Y705)   DYC4607B  
STAT5a/b (Y694/Y699)      
STAT6 (Y641)      
WNK-1(T60)   DYC4720  
Yes (Y426)   DYC3929  

Specifications

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Species
Human

Product Datasheets

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Data Example

Detection of Human Protein Kinase Phosphorylation in A549 Cell Line. A549 human lung adenocarcinoma cells were either left untreated or exposed to 50 J/m2 of UV light followed by a 24 hour recovery before lysis.

Detection of Human Protein Kinase Phosphorylation in Daudi Cell Line. Daudi human B cell lymphoma cells were either left untreated or treated with 500 U/ml recombinant human IFN-alpha 2a (R&D Systems®, Catalog # 11100-1) for 5 minutes.

Detection of Human Protein Kinase Phosphorylation in Jurkat Cell Line. Jurkat human acute T cell leukemia cells were either left untreated or treated with 100 ng/mL PMA and 0.5 mM Ionomycin for 20 minutes.

Detection of Human Protein Kinase Phosphorylation in MCF-7 Cell Line. MCF-7 human breast cancer cells were either left untreated or treated with 100 ng/mL of recombinant human IGF-1 (R&D Systems®, Catalog # 291-G1) for 1 hour.

Citations for Proteome Profiler Human Phospho-Kinase Array Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

349 Citations: Showing 1 - 10
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  1. Peroxiredoxin IV plays a critical role in cancer cell growth and radioresistance through the activation of the Akt/GSK3 signaling pathways
    Authors: N Ding, H Jiang, P Thapa, Y Hao, A Alshahrani, D Allison, T Izumi, VM Rangnekar, X Liu, Q Wei
    The Journal of Biological Chemistry, 2022;0(0):102123.  2022
  2. Macrophage SAMSN1 protects against sepsis-induced acute lung injury in mice
    Authors: W Jiang, C Ma, J Bai, X Du
    Redox Biology, 2022;56(0):102432.  2022
  3. ICAM-1 promotes cancer progression by regulating SRC activity as an adapter protein in colorectal cancer
    Authors: EJ Lim, JH Kang, YJ Kim, S Kim, SJ Lee
    Cell Death & Disease, 2022;13(4):417.  2022
  4. The Fibrinogen-like Domain of ANGPTL3 Facilitates Lipolysis in 3T3-L1 Cells by Activating the Intracellular Erk Pathway
    Authors: S Bini, V Pecce, A Di Costanz, L Polito, A Ghadiri, I Minicocci, F Tambaro, S Covino, M Arca, L D'Erasmo
    Biomolecules, 2022;12(4):.  2022
  5. Methylation-mediated silencing of protein kinase C zeta induces apoptosis avoidance through ATM/CHK2 inactivation in dedifferentiated chondrosarcoma
    Authors: E Shimada, Y Matsumoto, M Nakagawa, Y Susuki, M Endo, N Setsu, T Fujiwara, K Iida, A Nabeshima, K Yahiro, A Kimura, T Hirose, M Kanahori, R Oyama, Y Oda, Y Nakashima
    British Journal of Cancer, 2022;0(0):.  2022
  6. Ephrin B Activate Src Family Kinases in Fibroblasts Inducing Stromal Remodeling in Prostate Cancer
    Authors: M Kakarla, S ChallaSiva, MF Dufficy, V Gil, Y Filipovich, R Vickman, SE Crawford, SW Hayward, OE Franco
    Cancers, 2022;14(9):.  2022
  7. Non-canonical function of AGO2 augments T-cell receptor signaling in T-cell prolymphocytic leukemia
    Authors: T Braun, J Stachelsch, N Bley, S Oberbeck, M Otte, TA Müller, L Wahnschaff, M Gla beta, K Ommer, M Franitza, B Gathof, J Altmüller, M Hallek, D Auguin, S Hüttelmaie, A Schrader, M Herling
    Cancer Research, 2022;0(0):.  2022
  8. ARAF suppresses ERBB3 expression and metastasis in a subset of lung cancers
    Authors: J Mooz, K Riegel, H Ps, A Sadanandam, F Marini, M Klein, U Werner, W Roth, A Wilken-Sch, I Tegeder, K Rajalingam
    Science Advances, 2022;8(11):eabk1538.  2022
  9. Angiotensin II Exaggerates SARS-CoV-2 Specific T-Cell Response in Convalescent Individuals following COVID-19
    Authors: M Almutlaq, FA Mansour, J Alghamdi, Y Alhendi, AA Alamro, AA Alghamdi, HS Alamri, F Alroqi, T Barhoumi
    International Journal of Molecular Sciences, 2022;23(15):.  2022
  10. Exosomes from EGFR-Mutated Adenocarcinoma Induce a Hybrid EMT and MMP9-Dependant Tumor Invasion
    Authors: A Jouida, M O'Callagha, C Mc Carthy, A Fabre, P Nadarajan, MP Keane
    Cancers, 2022;14(15):.  2022
  11. Glycoproteogenomics characterizes the CD44 splicing code associated with bladder cancer invasion
    Authors: C Gaiteiro, J Soares, M Relvas-San, A Peixoto, D Ferreira, P Paulo, A Brandão, E Fernandes, R Azevedo, C Palmeira, R Freitas, A Miranda, H Osório, J Prieto, L Lima, AMN Silva, LL Santos, JA Ferreira
    Theranostics, 2022;12(7):3150-3177.  2022
  12. DDR1 promotes hepatocellular carcinoma metastasis through recruiting PSD4 to ARF6
    Authors: X Zhang, Y Hu, Y Pan, Y Xiong, Y Zhang, M Han, K Dong, J Song, H Liang, Z Ding, X Zhang, H Zhu, Q Liu, X Lu, Y Feng, X Chen, Z Zhang, B Zhang
    Oncogene, 2022;0(0):.  2022
  13. Idelalisib activates AKT via increased recruitment of PI3Kdelta/PI3Kbeta to BCR signalosome while reducing PDK1 in post-therapy CLL cells
    Authors: MK Mamidi, H Mahmud, GP Maiti, MT Mendez, SM Fernandes, SK Vesely, J Holter-Cha, JR Brown, AK Ghosh
    Leukemia, 2022;0(0):.  2022
  14. m6A methylation mediates LHPP acetylation as a tumour aerobic glycolysis suppressor to improve the prognosis of gastric cancer
    Authors: JX Lin, NZ Lian, YX Gao, QL Zheng, YH Yang, YB Ma, ZS Xiu, QZ Qiu, HG Wang, CH Zheng, P Li, JW Xie, J Lu, QY Chen, LL Cao, M Lin, JB Wang, CM Huang
    Cell Death & Disease, 2022;13(5):463.  2022
  15. GSK3beta palmitoylation mediated by ZDHHC4 promotes tumorigenicity of glioblastoma stem cells in temozolomide-resistant glioblastoma through the EZH2-STAT3 axis
    Authors: C Zhao, H Yu, X Fan, W Niu, J Fan, S Sun, M Gong, B Zhao, Z Fang, X Chen
    Oncogenesis, 2022;11(1):28.  2022
  16. Melatonin Modulation of Radiation-Induced Molecular Changes in MCF-7 Human Breast Cancer Cells
    Authors: C Alonso-Gon, C González-A, J Menéndez-M, A González-G, V Álvarez-Ga, A González-C, C Martínez-C, S Cos
    Biomedicines, 2022;10(5):.  2022
  17. Microglia/macrophage-derived human CCL18 promotes glioma progression via CCR8-ACP5 axis analyzed in humanized slice model
    Authors: Y Huang, E Motta, C Nanvuma, LD Kuhrt, Y Yuan, P Xia, M Lubas, S Zhu, M Schnauss, N Qazi, F Hu, H Zhang, T Lei, M Synowitz, C Flüh, H Kettenmann
    Cell Reports, 2022;39(2):110670.  2022
  18. Tsp2 Facilitates Tumor-associated Fibroblasts Formation and Promotes Tumor Progression in Retroperitoneal Liposarcoma
    Authors: C Xu, L Yan, X Guan, Z Wang, J Wu, A Lv, D Liu, F Liu, B Dong, M Zhao, L Jia, X Tian, C Hao
    International journal of biological sciences, 2022;18(13):5038-5055.  2022
  19. Macrophage-derived CCL23 upregulates expression of T-cell exhaustion markers in ovarian cancer
    Authors: K Kamat, V Krishnan, O Dorigo
    British Journal of Cancer, 2022;0(0):.  2022
  20. PTEN inhibits AMPK to control collective migration
    Authors: F Peglion, L Capuana, I Perfettini, L Boucontet, B Braithwait, E Colucci-Gu, E Quissac, K Forsberg-N, F Llense, S Etienne-Ma
    Nature Communications, 2022;13(1):4528.  2022
  21. SLC4A4 promotes prostate cancer progression in vivo and in vitro via AKT-mediated signalling pathway
    Authors: Z Liu, Q Wang, G Zhai, S Ke, X Yu, J Guo
    Cancer Cell International, 2022;22(1):127.  2022
  22. Post-translational dysregulation of glucose uptake during exhaustive cycling exercise in vastus lateralis muscle of healthy homozygous carriers of the ACE deletion allele
    Authors: M Flück, D Vaughan, J Rittweger, MN Giraud
    Frontiers in Physiology, 2022;13(0):933792.  2022
  23. Kayadiol exerted anticancer effects through p53-mediated ferroptosis in NKTCL cells
    Authors: C He, C Wang, H Liu, B Shan
    BMC Cancer, 2022;22(1):724.  2022
  24. Elevation of Hyaluronan Synthase by Magnesium Supplementation Mediated through the Activation of GSK3 and CREB in Human Keratinocyte-Derived HaCaT Cells
    Authors: K Marunaka, S Shu, M Kobayashi, M Goto, Y Katsuta, Y Yoshino, A Ikari
    International Journal of Molecular Sciences, 2021;23(1):.  2021
  25. Targeting uPA-uPAR interaction to improve intestinal epithelial barrier integrity in inflammatory bowel disease
    Authors: Y Cheng, TR Hall, X Xu, I Yung, D Souza, J Zheng, F Schiele, M Hoffmann, ML Mbow, JP Garnett, J Li
    EBioMedicine, 2021;75(0):103758.  2021
  26. mTOR modulates resistance to gemcitabine in lung cancer in an MTORC2 dependent mechanism
    Authors: MA Chawsheen, PR Dash
    Cellular Signalling, 2021;81(0):109934.  2021
  27. Lung macrophages drive mucus production and steroid-resistant inflammation in chronic bronchitis
    Authors: K Andelid, K Öst, A Andersson, E Mohamed, Z Jevnikar, LEGW Vanfletere, M Göransson
    Respiratory Research, 2021;22(1):172.  2021
  28. Autocrine vitamin D signaling switches off pro-inflammatory programs of TH1 cells
    Authors: D Chauss, T Freiwald, R McGregor, B Yan, L Wang, E Nova-Lampe, D Kumar, Z Zhang, H Teague, EE West, KM Vannella, MJ Ramos-Beni, J Bibby, A Kelly, A Malik, AF Freeman, DM Schwartz, D Portilla, DS Chertow, S John, P Lavender, C Kemper, G Lombardi, NN Mehta, N Cooper, MS Lionakis, A Laurence, M Kazemian, B Afzali
    Nature Immunology, 2021;0(0):.  2021
  29. Clofarabine induces ERK/MSK/CREB activation through inhibiting CD99 on Ewing sarcoma cells
    Authors: H Sevim, H Çelik, L Dü?ünceli, CS Ceyhan, A Molotkova, K Nakazawa, GT Graham, JR Petro, JA Toretsky, A Üren
    PLoS ONE, 2021;16(6):e0253170.  2021
  30. DDR1 contributes to kidney inflammation and fibrosis by promoting the phosphorylation of BCR and STAT3
    Authors: CM Borza, G Bolas, F Bock, X Zhang, FC Akabogu, MZ Zhang, M de Caestec, M Yang, HC Yang, E Lee, L Gewin, AB Fogo, WH McDonald, R Zent, A Pozzi
    JCI Insight, 2021;0(0):.  2021
  31. Protein kinase RNA-activated controls mitotic progression and determines paclitaxel chemosensitivity through B-cell lymphoma 2 in ovarian cancer
    Authors: L Yin, Y Zeng, R Zeng, Y Chen, TL Wang, KJ Rodabaugh, F Yu, A Natarajan, AR Karpf, J Dong
    Oncogene, 2021;0(0):.  2021
  32. Insights on Cancer Cell Inhibition, Subcellular Activities, and Kinase Profile of Phenylacetamides Pending 1H-Imidazol-5-One Variants
    Authors: MT Khayat, AM Omar, F Ahmed, MI Khan, SM Ibrahim, YA Muhammad, AM Malebari, T Neamatalla, ME El-Araby
    Frontiers in Pharmacology, 2021;12(0):794325.  2021
  33. Novel patient-derived models of DSRCT enable validation of ERBB signaling as a potential therapeutic vulnerability
    Authors: RS Smith, I Odintsov, Z Liu, AJ Lui, T Hayashi, M Vojnic, Y Suehara, L Delasos, MS Mattar, J Hmeljak, HA Ramirez, M Shaw, G Bui, AB Hartono, E Gladstone, S Kunte, H Magnan, I Khodos, E De Stanchi, MP La Quaglia, J Yao, M Laé, SB Lee, L Spraggon, CA Pratilas, M Ladanyi, R Somwar
    Disease Models & Mechanisms, 2021;0(0):.  2021
  34. New Treatment Strategy Targeting Galectin-1 against Thyroid Cancer
    Authors: L Gheysen, L Soumoy, A Trelcat, L Verset, F Journe, S Saussez
    Cells, 2021;10(5):.  2021
  35. GPR87 Promotes Metastasis through the AKT-eNOS-NO Axis in Lung Adenocarcinoma
    Authors: HM Ahn, EY Choi, YJ Kim
    Cancers, 2021;14(1):.  2021
  36. IL-36alpha and Lipopolysaccharide Cooperatively Induce Autophagy by Triggering Pro-Autophagic Biased Signaling
    Authors: ZII Al-Luhaibi, Á Dernovics, G Seprényi, F Ayaydin, Z Boldogk?i, Z Veréb, K Megyeri
    Biomedicines, 2021;9(11):.  2021
  37. The EGF Domains of MUC4 Oncomucin Mediate HER2 Binding Affinity and Promote Pancreatic Cancer Cell Tumorigenesis
    Authors: N Stoup, M Liberelle, C Schulz, S Cavdarli, R Vasseur, R Magnez, F Lahdaoui, N Skrypek, F Peretti, F Frénois, X Thuru, P Melnyk, N Renault, N Jonckheere, N Lebègue, I Van Seunin
    Cancers, 2021;13(22):.  2021
  38. Aerobic exercise intensity does not affect the anabolic signaling following resistance exercise in endurance athletes
    Authors: TW Jones, L Eddens, J Kupusarevi, DCM Simoes, MJW Furber, KA van Somere, G Howatson
    Scientific Reports, 2021;11(1):10785.  2021
  39. The Cardenolide Glycoside Acovenoside A Interferes with Epidermal Growth Factor Receptor Trafficking in Non-Small Cell Lung Cancer Cells
    Authors: S Hafner, M Schmiech, SJ Lang
    Frontiers in Pharmacology, 2021;12(0):611657.  2021
  40. Akt-mediated Ephexin1-Ras interaction promotes oncogenic Ras signaling and colorectal and lung cancer cell proliferation
    Authors: J Kim, YJ Jeon, SC Lim, J Ryu, JH Lee, IY Chang, HJ You
    Cell Death & Disease, 2021;12(11):1013.  2021
  41. Preclinical development of a bispecific TNFalpha/IL-23 neutralising domain antibody as a novel oral treatment for inflammatory bowel disease
    Authors: KJ Roberts, MF Cubitt, TM Carlton, L Rodrigues-, L Maggiore, R Chai, S Clare, K Harcourt, TT MacDonald, KP Ray, A Vossenkämp, MR West, JS Crowe
    Scientific Reports, 2021;11(1):19422.  2021
  42. Prognostic and therapeutic significance of COP9 signalosome subunit CSN5 in prostate cancer
    Authors: YZ Mazzu, YR Liao, S Nandakumar, LE Jehane, RP Koche, SH Rajanala, R Li, H Zhao, TA Gerke, G Chakrabort, GM Lee, GJ Nanjangud, A Gopalan, Y Chen, PW Kantoff
    Oncogene, 2021;0(0):.  2021
  43. Exogenous bacterial DnaK increases protein kinases activity in human cancer cell lines
    Authors: F Benedetti, S Curreli, RC Gallo, D Zella
    Journal of Translational Medicine, 2021;19(1):60.  2021
  44. TGF-&beta1-mediated transition of resident fibroblasts to cancer-associated fibroblasts promotes cancer metastasis in gastrointestinal stromal tumor
    Authors: H Yoon, CM Tang, S Banerjee, AL Delgado, M Yebra, J Davis, JK Sicklick
    Oncogenesis, 2021;10(2):13.  2021
  45. Glycosyltransferase POMGNT1 deficiency strengthens N-cadherin-mediated cell-cell adhesion
    Authors: SI Noor, M Hoffmann, N Rinis, MF Bartels, PR Winterhalt, C Hoelscher, R Hennig, N Himmelreic, C Thiel, T Ruppert, E Rapp, S Strahl
    The Journal of Biological Chemistry, 2021;0(0):100433.  2021
  46. Androgen Receptor Activation in Glioblastoma Can Be Achieved by Ligand-Independent Signaling through EGFR-A Potential Therapeutic Target
    Authors: N Zalcman, M Gutreiman, T Shahar, M Weller, I Lavon
    International Journal of Molecular Sciences, 2021;22(20):.  2021
  47. Identification of Radil as a Ras binding partner and putative activator
    Authors: BH Choi, Z Kou, TM Colon, CH Chen, Y Chen, W Dai
    The Journal of Biological Chemistry, 2021;0(0):100314.  2021
  48. SIRT2 regulates mitochondrial dynamics and reprogramming via MEK1-ERK-DRP1 and AKT1-DRP1 axes
    Authors: Y Cha, T Kim, J Jeon, Y Jang, PB Kim, C Lopes, P Leblanc, BM Cohen, KS Kim
    Cell Reports, 2021;37(13):110155.  2021
  49. Comprehensive molecular characterization of lung tumors implicates AKT and MYC signaling in adenocarcinoma to squamous cell transdifferentiation
    Authors: A Quintanal-, H Taniguchi, YA Zhan, MM Hasan, SS Chavan, F Meng, F Uddin, V Allaj, P Manoj, NS Shah, JM Chan, M Ciampricot, A Chow, M Offin, J Ray-Kirton, JD Egger, UK Bhanot, I Linkov, M Asher, MH Roehrl, K Ventura, J Qiu, E de Stanchi, JC Chang, N Rekhtman, B Houck-Loom, RP Koche, HA Yu, T Sen, CM Rudin
    Journal of hematology & oncology, 2021;14(1):170.  2021
  50. BUB1B promotes extrahepatic cholangiocarcinoma progression via JNK/c-Jun pathways
    Authors: CY Jiao, QC Feng, CX Li, D Wang, S Han, YD Zhang, WJ Jiang, J Chang, X Wang, XC Li
    Cell Death & Disease, 2021;12(1):63.  2021
  51. Combinatorial Effect of PLK1 Inhibition with Temozolomide and Radiation in Glioblastoma
    Authors: A Pandey, SC Tripathi, J Mai, SM Hanash, H Shen, S Mitra, RC Rostomily
    Cancers, 2021;13(20):.  2021
  52. Targeting Discoidin Domain Receptors DDR1 and DDR2 overcomes matrix-mediated tumor cell adaptation and tolerance to BRAF-targeted therapy in melanoma
    Authors: I Berestjuk, M Lecacheur, A Carminati, S Diazzi, C Rovera, V Prod'homme, M Ohanna, A Popovic, A Mallaviall, F Larbret, S Pisano, S Audebert, T Passeron, C Gaggioli, CA Girard, M Deckert, S Tartare-De
    Embo Molecular Medicine, 2021;0(0):e11814.  2021
  53. S100A8/A9 mediate the reprograming of normal mammary epithelial cells induced by dynamic cell-cell interactions with adjacent breast cancer cells
    Authors: SH Jo, WH Heo, HY Son, M Quan, BS Hong, JH Kim, HB Lee, W Han, Y Park, DS Lee, NH Kwon, MC Park, J Chae, JI Kim, DY Noh, HG Moon
    Scientific Reports, 2021;11(1):1337.  2021
  54. Temporal profiling of therapy resistance in human medulloblastoma identifies novel targetable drivers of recurrence
    Authors: D Bakhshinya, AA Adile, J Liu, WD Gwynne, Y Suk, S Custers, I Burns, M Singh, N McFarlane, MK Subapandit, MA Qazi, P Vora, MM Kameda-Smi, N Savage, KL Desmond, N Tatari, D Tran, M Seyfrid, K Hope, NA Bock, C Venugopal, GD Bader, SK Singh
    Science Advances, 2021;7(50):eabi5568.  2021
  55. Tyrosine kinase independent actions of DDR2 in tumor cells and CAFs influence tumor invasion, migration, and metastasis
    Authors: CE Barcus, PY Hwang, V Morikis, A Brenot, P Pence, M Clarke, GD Longmore
    Journal of Cell Science, 2021;0(0):.  2021
  56. Protein Phosphatase 1 Regulates Human Cytomegalovirus Protein Translation by Restraining AMPK Signaling
    Authors: C Stecher, S Marinkov, L Mayr-Harti, A Katic, MT Kastner, FJJ Rieder-Rom, X Lin, S Nekhai, C Steininger
    Frontiers in Microbiology, 2021;12(0):698603.  2021
  57. RGS5 Attenuates Baseline Activity of ERK1/2 and Promotes Growth Arrest of Vascular Smooth Muscle Cells
    Authors: E Demirel, C Arnold, J Garg, MA Jäger, C Sticht, R Li, H Kuk, N Wettschure, M Hecker, T Korff
    Cells, 2021;10(7):.  2021
  58. SHED-Dependent Oncogenic Signaling of the PEAK3 Pseudo-Kinase
    Authors: Y Ounoughene, E Fourgous, Y Boublik, E Saland, N Guiraud, C Recher, S Urbach, P Fort, JE Sarry, D Fesquet, S Roche
    Cancers, 2021;13(24):.  2021
  59. CD63-mediated cloaking of VEGF in small extracellular vesicles contributes to anti-VEGF therapy resistance
    Authors: S Ma, LS Mangala, W Hu, E Bayaktar, A Yokoi, W Hu, S Pradeep, S Lee, PD Piehowski, A Villar-Pra, SY Wu, MH McGuire, OD Lara, C Rodriguez-, CJ LaFargue, NB Jennings, KD Rodland, T Liu, V Kundra, PT Ram, S Ramakrishn, G Lopez-Bere, RL Coleman, AK Sood
    Cell Reports, 2021;36(7):109549.  2021
  60. PIK3R3, part of the regulatory domain of PI3K, is upregulated in sarcoma stem-like cells and promotes invasion, migration, and chemotherapy resistance
    Authors: C Yoon, J Lu, SW Ryeom, MC Simon, SS Yoon
    Cell Death & Disease, 2021;12(8):749.  2021
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Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 08/02/2022

Used human lymphoma samples! Worked fine!


Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 08/02/2022

Used this kit with mouse lymphoma cell lines and it worked!


Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 09/16/2021

Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 07/15/2021

Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 03/21/2021

Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 01/27/2021

Proteome Profiler Human Phospho-Kinase Array Kit
By APK Inmunometabolismo on 11/06/2020

Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 03/18/2020

Some of the antibodies lack sensitivity. Independent comprobation using the exact same protocol (lysis buffer, etc) and conventional WB rendered higher activation than the kit's


Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 01/21/2020